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Journal articles on the topic 'Thermal hypoalgesia method'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Kousar, Begum* Naziya Begum Shaik Reshma Wajiha Fatima Mariyanaaz Ali and Ayesha Sultana. "PTEROCARPUS MARSUPIUM EXTRACTION AND EVALUATION FOR DIABETIC NEUROPATHY." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 1888–97. https://doi.org/10.5281/zenodo.826969.

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Herbal medicines are considered to offer gentle means of managing chronic diseases at a lower cost. Traditional Medicines derived from medicinal plants are used by about 60% of the world’s population. Diabetes is an important human ailment afflicting many from various walks of life in different countries. In India it is proving to be a major health problem, especially in the urban areas. Pterocarpus marsupium. (PM) heartwood and bark have been majorly used as antidiabetic remedies in many cultures for thousands of years. The aim of this research is to address the existing evidence on antidiabe

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Safakhah, Hossein Ali, Abbas Ali Vafaei, Azin Tavasoli, Simin Jafari, and Ali Ghanbari. "Role of Muscarinic Receptors in Hypoalgesia Induced by Crocin in Neuropathic Pain Rats." Scientific World Journal 2020 (November 25, 2020): 1–7. http://dx.doi.org/10.1155/2020/4046256.

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Objective. Crocin as an important constituent of saffron has antineuropathic pain properties; however, the exact mechanism of this effect is not known. The aim of this study was whether the hypoalgesic effect of crocin can be exerted through muscarinic receptors. Materials and Methods. In the present project, 36 male Wistar rats (200 ± 20 g) were used. Animals randomly divided into six groups (sham, neuropathy, neuropathy + crocin, neuropathy + atropine 0.5 mg/kg, neuropathy + atropine 1 mg/kg, and neuropathy + atropine 1 mg/kg + crocin). Neuropathy was induced by the chronic constriction inju

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Jones, Matthew D., James L. Nuzzo, Janet L. Taylor, and Benjamin K. Barry. "Aerobic Exercise Reduces Pressure More Than Heat Pain Sensitivity in Healthy Adults." Pain Medicine 20, no. 8 (2019): 1534–46. http://dx.doi.org/10.1093/pm/pny289.

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Abstract Objectives The hypoalgesic effects of exercise are well described, but there are conflicting findings for different modalities of pain; in particular for mechanical vs thermal noxious stimuli, which are the most commonly used in studies of exercise-induced hypoalgesia. The aims of this study were 1) to investigate the effect of aerobic exercise on pressure and heat pain thresholds that were well equated with regard to their temporal and spatial profile and 2) to identify whether changes in the excitability of nociceptive pathways—measured using laser-evoked potentials—accompany exerci

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Paley, Carole A., and Mark I. Johnson. "Investigation into the Effects of Using Two Or Four Acupuncture Needles with Bidirectional Rotation on Experimentally-Induced Contact Heat Pain in Healthy Subjects." Acupuncture in Medicine 33, no. 1 (2015): 23–29. http://dx.doi.org/10.1136/acupmed-2014-010617.

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Objectives There is growing evidence from experimental studies that the acupuncture dose or technique influences the speed of onset of hypoalgesia. The aim of this study was to investigate the effects of acupuncture using two or four needles on experimental contact thermal pain in healthy volunteers. Methods Forty two participants were randomised into three groups: four-needle group (LI4, LI11, LI10, TE5), two-needle group (verum at LI4, LI11 and mock at LI10, TE5) and mock acupuncture group (LI4, LI11, LI10, TE5). Each participant rated pain intensity (visual analogue scale, VAS) to a series

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Calcutt, Nigel A., Jason D. Freshwater, and John S. O’Brien. "Protection of Sensory Function and Antihyperalgesic Properties of a Prosaposin-derived Peptide in Diabetic Rats." Anesthesiology 93, no. 5 (2000): 1271–78. http://dx.doi.org/10.1097/00000542-200011000-00021.

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Background Short-term diabetes causes sensory disorders in rats ranging from thermal hypoalgesia to exaggerated behavioral responses to other sensory stimuli. As impaired neurotrophic support may promote sensory nerve disorders during diabetes, the authors investigated whether TX14(A), a neurotrophic peptide derived from prosaposin, was able to ameliorate nerve disorders in diabetic rats. Methods TX14(A) was delivered by intraperitoneal or intrathecal injection to control or streptozotocin-diabetic rats in either single or multiple (three times weekly) dose regimens. Efficacy was measured agai

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Khaleghzadeh-Ahangar, Hossein, Forouzan Sadeghimahalli, Shaghayegh Khandan, Sima Shahabi, and Aliakbar Moghadamnia. "Insulin Within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic Rats." Basic and Clinical Neuroscience Journal 11, no. 6 (2020): 727–36. http://dx.doi.org/10.32598/bcn.11.6.1983.1.

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Introduction: Broad neural circuits originate from the hypothalamic arcuate nucleus and project to many parts of the brain which are related to pain perception. Insulin receptors are found in the arcuate nucleus. Since nociception may be affected in type 1 diabetes, the present study aimed to investigate the intra-arcuate nucleus insulin role in pain perception in streptozotocin (STZ)-induced diabetic and healthy rats. Methods: Regular insulin was microinjected within the arcuate nucleus and the pain tolerance was measured using the hot plate and the tail-flick apparatus in diabetic rats. Resu

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Sorkin, Linda S., Tony L. Yaksh, and Carmen M. Doom. "Pain Models Display Differential Sensitivity to Ca2+-Permeable Non-NMDA Glutamate Receptor Antagonists." Anesthesiology 95, no. 4 (2001): 965–73. http://dx.doi.org/10.1097/00000542-200110000-00028.

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Background Ca2+-permeable non-N-methyl-D-aspartate receptors are found in the spinal dorsal horn and represent a presumptive target for glutamatergic transmission in nociceptive processing. This study characterized the analgesic profile associated with the blockade of these spinal receptors by intrathecally delivered agents known to act at these receptors, the spider venom Joro toxin (JST) and philanthotoxin. Methods Philanthotoxin (0.5, 2.5, or 5 microg) or JST (5 microg) was given spinally before thermal injury to the paw. JST (5 microg) was also given 10 min before subcutaneous formalin inj

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Safakhah, Hossein Ali, Farzaneh Tamimi, Nasroallah Moradi kor, Ahmad Reza Bandegi, and Ali Ghanbari. "Hypoalgesic effect of Spirulina platensis on the sciatic neuropathic pain induced by chronic constriction injury in male rats." Biomedical Research and Therapy 5, no. 9 (2018): 2671–79. http://dx.doi.org/10.15419/bmrat.v5i9.477.

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Background: It has been revealed that herbal medicines have a palliative effect on pain. In the present study, the hypoalgesic effect of Spirulina platensis (microalgae) on the neuropathic pain induced by chronic constriction injury (CCI) was investigated. Methods: In the present study, 74 adult male Wistar rats weighing 200-220 grams were used. For inducing neuropathic pain, CCI was performed on the left sciatic nerve. Spirulina platensis was intragastrically administered daily for 3 weeks. Mechanical allodynia and thermal hyperalgesia were assessed by Von Frey hairs and plantar test de

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Coppey, Lawrence J., Amey Holmes, Eric P. Davidson, and Mark A. Yorek. "Partial Replacement with Menhaden Oil Improves Peripheral Neuropathy in High-Fat-Fed Low-Dose Streptozotocin Type 2 Diabetic Rat." Journal of Nutrition and Metabolism 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/950517.

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Aims. To determine the effect of partial replacement of a high-fat diet with menhaden oil on diabetic neuropathy in an animal model of type 2 diabetes.Materials and Methods. High-fat/low-dose streptozotocin diabetic rats were used to examine the influence of replacing 50% of the source of the high-fat diet (lard) with menhaden oil, a natural source of n-3 fatty acids, on diabetic neuropathy. Endpoints included analyses of glucose tolerance, fatty liver disease, serum and liver fatty acid composition, serum lipid and adiponectin levels, motor and sensory nerve conduction velocity, thermal sensi

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10

Nozaki-Taguchi, Natsuko, and Tony L. Yaksh. "Characterization of the Antihyperalgesic Action of a Novel Peripheral Mu-opioid Receptor Agonist-Loperamide." Anesthesiology 90, no. 1 (1999): 225–34. http://dx.doi.org/10.1097/00000542-199901000-00029.

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Background Preclinical and clinical evidence indicates that locally administered opioid agonists produce an antihyperalgesic effect through peripheral opioid receptors in inflamed tissue. Loperamide, a mu opioid agonist, does not cross the blood-brain barrier and therefore lacks central effects after systemic administration. The authors defined the effects of topical loperamide on a thermal injury-induced hyperalgesia. Methods In halothane-anesthetized rats, thermal injury was induced by placing the plantar surface of a hindpaw on a hot plate (52.0+/-1 degrees C) for 45 s. Loperamide was prepa

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11

Uglem, Martin, Petter Moe Omland, Kristian Bernhard Nilsen, et al. "Does pain sensitivity change by migraine phase? A blinded longitudinal study." Cephalalgia 37, no. 14 (2016): 1337–49. http://dx.doi.org/10.1177/0333102416679955.

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Objective Studies suggest that pain thresholds may be altered before and during migraine headaches, but it is still debated if a central or peripheral dysfunction is responsible for the onset of pain in migraine. The present blinded longitudinal study explores alterations in thermal pain thresholds and suprathreshold heat pain scores before, during, and after headache. Methods We measured pain thresholds to cold and heat, and pain scores to 30 seconds of suprathreshold heat four times in 49 migraineurs and once in 31 controls. Sessions in migraineurs were categorized by migraine diaries as int

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12

Wojtyna, Ewa, Magdalena Hyla, and Aleksandra Hachuła. "Pain of Threatened Self: Explicit and Implicit Self-Esteem, Cortisol Responses to a Social Threat and Pain Perception." Journal of Clinical Medicine 13, no. 9 (2024): 2705. http://dx.doi.org/10.3390/jcm13092705.

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Background: Rejection, injustice, and exclusion from meaningful interpersonal relationships are often extremely painful and stress-generating experiences. This study aimed to define the role of explicit and implicit self-esteem in pain perception as a component of the physiological–psychological system that regulates the body’s response to stress associated with the threat of social rejection. Methods: In total, 360 individuals participated in this study. The measurement of cortisol in saliva, the assessment of pain thresholds using thermal stimuli, the IAT to assess implicit self-esteem, and

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13

Harris, Samuel, Michele Sterling, Scott F. Farrell, Ashley Pedler, and Ashley D. Smith. "The influence of isometric exercise on endogenous pain modulation: comparing exercise-induced hypoalgesia and offset analgesia in young, active adults." Scandinavian Journal of Pain 18, no. 3 (2018): 513–23. http://dx.doi.org/10.1515/sjpain-2017-0177.

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Abstract Background and aims Impairment of endogenous analgesia has been associated with the development, maintenance and persistence of pain. Endogenous analgesia can be evaluated using exercise-induced hypoalgesia (EIH) and offset analgesia (OffA) paradigms, which measure temporal filtering of sensory information. It is not clear if these paradigms are underpinned by common mechanisms, as EIH and OffA have not previously been directly compared. A further understanding of the processes responsible for these clinically relevant phenomena may have future diagnostic and therapeutic utility in ma

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Levy, Dan, Hila Gruener, Miri Riabinin, et al. "Different clinical phenotypes of persistent post-traumatic headache exhibit distinct sensory profiles." Cephalalgia 40, no. 7 (2019): 675–88. http://dx.doi.org/10.1177/0333102419896368.

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Introduction Persistent post-traumatic headache remains a poorly understood clinical entity. Although there are currently no accepted therapies for persistent post-traumatic headache, its clinical symptoms, which primarily resemble those of migraine or tension-type headache, often serve to guide treatment. However, evidence-based justification for this treatment approach remains lacking given the paucity of knowledge regarding the characteristics of these two major persistent post-traumatic headache phenotypes and their etiology. Methods We compared clinical features and quantitative sensory t

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15

Liu, Shunxin, Qin Li, Huaiming Wang, et al. "Exercise as a promising alternative for sciatic nerve injury pain relief: a meta-analysis." Frontiers in Neurology 15 (July 31, 2024). http://dx.doi.org/10.3389/fneur.2024.1424050.

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ObjectiveThe efficacy of drug therapies in managing neuropathic pain is constrained by their limited effectiveness and potential for adverse effects. In contrast, exercise has emerged as a promising alternative for pain relief. In this study, we conducted a systematic evaluation of the therapeutic impact of exercise on neuropathic pain resulting from sciatic nerve injury in rodent models.MethodsThe PubMed, Embase, and Web of Science databases were retrieved before April 2024. A series of studies regarding the effect of treadmill, swimming, wheel and other exercises on neuropathic pain induced

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16

Sasajima, Sachiko, Masaki Kondo, Nobuhiko Ohno, et al. "Thermal gradient ring reveals thermosensory changes in diabetic peripheral neuropathy in mice." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-14186-x.

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AbstractDiabetic peripheral neuropathy (DPN) includes symptoms of thermosensory impairment, which are reported to involve changes in the expression or function, or both, of nociceptive TRPV1 and TRPA1 channels in rodents. In the present study, we did not find changes in the expression or function of TRPV1 or TRPA1 in DPN mice caused by STZ, although thermal hypoalgesia was observed in a murine model of DPN or TRPV1−/− mice with a Plantar test, which specifically detects temperature avoidance. With a Thermal Gradient Ring in which mice can move freely in a temperature gradient, temperature pref

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17

Tomschi, Fabian, Dennis Lieverkus, and Thomas Hilberg. "Exercise-induced hypoalgesia (EIH) in response to different exercise intensities." European Journal of Applied Physiology, July 9, 2022. http://dx.doi.org/10.1007/s00421-022-04997-1.

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Abstract Purpose Acute physical activity leads to exercise-induced hypoalgesia (EIH). The aim of this study was to investigate the effects of four different exercise intensities on EIH. Methods 25 male (age: 24.7 ± 3.0) subjects underwent four different exercise sessions on a bicycle ergometer for 30 min each at 60, 80, 100, and 110% of the individual anaerobic threshold on separate days in a randomized crossover design. Before, as well as 5- and 45-min post-exercise, pain sensitivity was measured employing pain pressure thresholds (PPT) at the elbow, knee, and ankle joints as well as the ster

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18

Aron, Vladimir, Louise Deldicque, and André Mouraux. "O.2.1-6 Effects of test modality and testing site on exercise-induced hypoalgesia in healthy human males: a protocol." European Journal of Public Health 33, Supplement_1 (2023). http://dx.doi.org/10.1093/eurpub/ckad133.111.

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Abstract Background A single session of physical exercise can acutely reduce experimental pain—a phenomenon known as exercise-induced hypoalgesia (EIH). There is inconsistency in the literature as to (1) whether EIH differentially impact the perception of different types of nociceptive stimuli (e.g., pressure versus thermal stimuli) and (2) whether exercise selectively modulates pain at exercising body parts, or also involves non-exercising body parts. Purpose We aim to characterize the effects of a single session of aerobic exercise on the sensitivity to stimuli activating skin versus muscle

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Heles, Mario, Petra Mrozkova, Dominika Sulcova, Pavel Adamek, Diana Spicarova, and Jiri Palecek. "Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn." Journal of Neuroinflammation 18, no. 1 (2021). http://dx.doi.org/10.1186/s12974-021-02335-4.

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Abstract Background Opioid analgesics remain widely used for pain treatment despite the related serious side effects. Some of those, such as opioid tolerance and opioid-induced hyperalgesia may be at least partially due to modulation of opioid receptors (OR) function at nociceptive synapses in the spinal cord dorsal horn. It was suggested that increased release of different chemokines under pathological conditions may play a role in this process. The goal of this study was to investigate the crosstalk between the µOR, transient receptor potential vanilloid 1 (TRPV1) receptor and C–C motif liga

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