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Dissertations / Theses on the topic 'Thermotherapie'

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Published: 4 June 2021
Last updated: 31 August 2024

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1

Stroszczynski, Christian. "Einsatz der Magnetresonanztomographie zur Laser-induzierten Thermotherapie." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/13821.

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Thermoablationsverfahren werden in der klinischen Routine zur Therapie bei Patienten mit primären Lebertumoren und Lebermetastasen eingesetzt, bei denen von einer Operation abgesehen wird. Die laserinduzierte Thermotherapie (LITT) ist ein minimal invasives radiologisches Verfahren zur perkutanen Tumorablation. Mit der Magnetresonanztomographie (MRT) am Hochfeldtomographen (1.5 Tesla) steht eine radiologische Methode mit der Option einer präzisen Prozesskontrolle der Thermoablation und einer suffizienten Erfolgskontrolle zur Verfügung. Ziel dieser Arbeit war es, im Tierexperiment die Anwendung der LITT zur Ablation von Pankreasgewebe zu erproben, das Potenzial der MRT für die Prozesskontrolle der LITT am Pankreas zu bestimmen und neue MRT-Sequenzen mit neuen Kontrastmitteln für die Optimierung der Erfolgskontrolle zu erforschen. Die LITT am Pankreas im Rahmen einer Pilotstudie an 15 Läuferschweinen war perkutan komplikationsarm durchführbar, generalisierte Pankreatitiden oder Blutungen traten nicht auf. Die qualitative Prozessbeobachtung mittels thermosensitiver Sequenzen zeigte eine hohe Übereinstimmung zwischen magnetresonanztomographisch dokumentierten Thermoeffekten und histopathologisch verifizierten thermisch induzierten Nekrosen. Die Untersuchung und invasive Kalibrierung verschiedener Messmethoden in vivo zur quantitativen MRT-Thermometrie ergab Vorteile für den Einsatz der Protonenresonanzfrequenz-Methode. Zur Optimierung der Erfolgskontrolle nach LITT von Lebergewebe im Tierexperiment sowie klinisch bei Lebermetastasen wurden die MRT-Kontrastmittel Gadomesoporphyrin, Eisenoxid und Gadobutrol erprobt. Mittels Spätaufnahmen 6 - 18 h post injectionem wurden mit Gadobutrol thermisch induzierte Nekrosen präzise visualisiert.<br>Thermoablation of primary liver tumors and liver metastases is widely used in patients without surgical options. The laser-induced thermotherapy (LITT) is a minimal invasive radiologic procedure for percutaneous tumor ablation. With high field magnetic resonance imaging at 1.5, monitoring of thermoablation and visualization of thermal induced ablation zones can be performed precisely. Aim of this work was to investigate the feasibility of MR-guided LITT of pancreatic tissue and to optimise the contrast between thermal induced lesions, residual tumor and normal tissue after LITT procedure. MR-guided LITT was feasible in 15 female pigs, generalized pancreatitis or bleeding did not occur. MR monitoring by thermosensitive sequences precisely visualized thermal induced ablation zones verified by histopathologic examination. Best results of MR thermometry (thermo-mapping) were obtained by proton resonance frequency method. Gadolinum- mesoporphyrine, superparamagnetic iron oxides (SPIO) and gadobutrol were used to optimise ablation control. Late enhanced imaging 6 - 18 hours after injection of gadobutrol precisely visualized thermal induced necrosis. In conclusion, percutaneous MR guided LITT of pancreatic tissue of female pigs was feasible and monitoring of thermoablation could be performed accurately. In contrast to other imaging methods, MR using new contrast agents enables accurate visualization of thermal induced necrosis.
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2

Gravas, Stavros. "TUMT treatment of BPH from evidence based guidelines to clinical practice /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/45890.

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Träger, Sylvia Johanna. "Hochfrequenzstrominduzierte Thermotherapie maligner Lebertumoren Applikatorenerprobung an der gesunden Schweineleber /." [S.l.] : [s.n.], 2000. http://www.diss.fu-berlin.de/2000/146/index.html.

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4

Tabary, Marc. "Etude et faisabilite d'un reseau informatique pour la supervision et la gestion d'un service d'hyperthermie clinique." Lille 2, 1990. http://www.theses.fr/1990LIL2P255.

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5

Ernst, Sandra. "Ergebnisse der laserinduzierten Thermotherapie (LITT) in der Behandlung von Lebertumoren." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967644771.

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6

Boerner, Anke. "Einfluss der laserinduzierten Thermotherapie (LITT) auf residuales Tumorgewebe im Vergleich zur Leberresektion." [S.l.] : [s.n.], 2000. http://www.diss.fu-berlin.de/2000/111/index.html.

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7

Behrendt, Nicole [Verfasser]. "CT-Perfusion von Lungenmetastasen vor und nach laserinduzierter Thermotherapie (LITT) / Nicole Behrendt." Greifswald : Universitätsbibliothek Greifswald, 2011. http://d-nb.info/1015330762/34.

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8

Kandulla, Jochen [Verfasser]. "Experimentelle und theoretische Untersuchungen zur optoakustischen Temperaturbestimmung während Transpupillarer Thermotherapie / Jochen Kandulla." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2010. http://d-nb.info/1004771967/34.

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9

Jourdain, Laurence. "L'hyperthermie et ses applications aux traitements des cancers." Paris 5, 1997. http://www.theses.fr/1997PA05P138.

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10

Stroszczynski, Christian. "Einsatz der Magnetresonanztomographie zur Laser-induzierten Thermotherapie Anwendungsgebiete Optimierung der Prozess- und Erfolgskontrolle /." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=965424030.

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11

Grabig, Anja. "Magnetresonanztomographisch gestützte laserinduzierte Thermotherapie am Pankreas des Schweins in vivo mit histopathologischer Korrelation." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15531.

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Das Pankreaskarzinom hat bei steigender Inzidenz eine äußerst schlechte Prognose und ist häufig bei Diagnosestellung nicht mehr kurativ operabel. Die laserinduzierte Thermotherapie (LITT) gewann in den letzten Jahren zunehmend an Bedeutung als ein minimal invasives Verfahren zur perkutanen Ablation von parenchymatösen Tumoren. Dabei ist die Magnetresonanztomographie (MRT) eine Methode, mit der eine präzise Prozesskontrolle der Thermoablation und eine suffiziente Erfolgskontrolle zur Verfügung stehen. Ziel der vorliegenden Studie war es, im Tierexperiment die Anwendung der LITT zur Ablation von Pankreasgewebe am Schwein zu erproben, sowie die Möglichkeiten der MRT als Online-Monitoringverfahren mit Hilfe einer histopathologischen Korrelation zu untersuchen. Dazu wurde an 15 Läuferschweinen das Pankreas einer perkutanen laserinduzierten Thermotherapie mit einer Leistung von 5, 10 und 20 Watt sowie zwei mal 5 Watt in Multiapplikatortechnik unter MRT Prozesskontrolle unterzogen. Anschließend wurde das Pankreasgewebe histologische aufgearbeitet und die magnetresonanztomographisch detektierten Läsionen histopathologisch korreliert. Das Auftreten einer schwerwiegenden Komplikation wie einer generalisierten Pankreatitis, Peritonitis oder Blutung wurde nicht beobachtet. Die durchgeführten Korrelationsanalysen zeigen eine hohe Übereinstimmung zwischen magnetresonanztomographisch dokumentiertem Thermoeffekt und histopathologisch verifizierter thermisch induzierter Nekrose. Interessanterweise wurden bei Anwendung von zwei Lasern niedriger Leistung in Multiapplikatortechnik, im Vergleich zur Anwendung von einem Laser mit höherer Leistung, größere Nekrosen induziert. Unsere Ergebnisse zeigen, dass die LITT ein geeignetes und sicheres minimalinvasives Verfahren zur Ablation von Pankreasparenchym unter MRT-Monitoring ist. Weiterführende Untersuchungen zur Durchführbarkeit und Ermittlung der Genauigkeit der MRT als Monitoringverfahren sind erforderlich.<br>Pancreatic carcinoma has an increasing incidence and a poor prognosis. Frequently at diagnosis pancreatic tumors are surgically unresectable. Laser-induced thermotherapy has become an area of considerable interest during the past few years as a minimally invasive method for percutanous ablation of parenchymatous tumors. With magnetic resonance imaging (MRI) an accurate process control of thermocoagulation and a sufficient control of performance are possible. Control of carcinoma growth of is still a problem. Therefore the aim of this study was to investigate the application of laser induced thermotherapy for ablation of pancreas in a porcine model and the possibility of MRI as an online-monitoring with histopathologic correlation. Laser applicators with energy of 5, 10, 20 and two lasers of 5 watt were placed in the pancreas of 15 female pigs. After sacrifice a pathological examination was performed and histological lesions were correlated with magnetic resonance detected lesions. No serious adverse event like generalized pancreatitis, peritonitis or bleeding was observed. Correlation analysis showed a high correspondence between magnetic resonance documented thermoeffects and histopathologic verified lesions. Thermally induced lesions were best visualised on contrast-enhanced T1-weighted images. Interestingly application of two lasers with each 5 watt, greater lesions were generated than on application of one laser with higher energy. Over a period of 7 days increasing inhomogeneity and contraction of lesions were observed. Our results show that laser-induced thermotherapy of pancreatic tissue was feasible in this porcine model, and online monitoring was practicable. Further studies are necessary to increase the accuracy of online MR imaging of thermal effects.
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12

Hamdous, Yasmina. "Formulation et caractérisation de nanoparticules magnétiques d’origine bactérienne pour des applications médicales." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS560.

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La société Nanobactérie développe un traitement thermique innovant contre le cancer qui repose sur l‘utilisation de nanoparticules d‘oxyde de fer d‘origine bactérienne, appelées magnétosomes. Celles-ci sont injectées directement dans la tumeur puis activées par le champ magnétique alternatif. Cette activation crée une augmentation locale de la température provoquant la destruction de la tumeur, sans affecter les tissus sains environnants. Afin d‘éviter les problèmes de toxicité liés à la présence d‘endotoxines bactériennes à la surface des magnétosomes, un processus de purification est utilisé. Il permet l‘élimination de toute la membrane organique immunogène et de garder ainsi le minéral responsable de l‘activité thermique. Cependant, l‘élimination de cette membrane entraîne l‘agrégation des magnétosomes. La première étape de ce travail de thèse a donc consisté à stabiliser les magnétosomes purifiés, et l'‘identification du meilleur revêtement a été évaluée. Dans une deuxième partie, une nouvelle modalité de chauffage a été mise au point pour augmenter l‘efficacité de l‘hyperthermie magnétique dans la destruction de cellules cancéreuses<br>The Nanobactérie company develops a novel strategy of cancer treatment using iron oxide nanoparticles of bacterial origin, called magnetosomes. These nanoparticles are injected directly into the tumor and then activated by an alternating magnetic field. Activated nanoparticles trigger a highly localized rise of temperature, inducing the destruction of the tumor without any adverse effects on adjacent healthy tissues. To avoid the problems of toxicity caused by the presence of bacterial endotoxin which present on the surface of magnetosomes extracted from bacteria, a process of purification is realized to eliminate all the immunogenic organic membrane and keep only the mineral responsible for the thermal activity. However, since elimination of this membrane causes the aggregation of the magnetosomes which become unstable in aqueous solution, the first part of this work consisted in stabilizing the purified magnetosomes by a modification of their surface. The identification of the best coating was then evaluated. Moreover, in the second part of this work, a new heating modality was assessed to increase the efficiency of the magnetic hyperthermia in the destruction of cancer cells
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13

Straub, Ralf. "Laserinduzierte interstitielle Thermotherapie (LITT) maligner Lebertumoren Evaluation der lokalen Tumorkontrollraten, der Komplikationen und Überlebenszeiten /." [S.l.] : [s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=960985549.

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14

Faby, Hendrik [Verfasser]. "Temperaturabhängige VEGF Induktion im humanen RPE - Mögliche Bedeutung für die Transpupilläre Thermotherapie / Hendrik Faby." Kiel : Universitätsbibliothek Kiel, 2016. http://d-nb.info/111473506X/34.

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15

Roesler, Martin. "Experimentelle Evaluation der Laser-induzierten Thermotherapie (LITT) an Ex-vivo-Rinderleber unter Verwendung zweier Kühlmedien." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976480735.

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16

Bössenrodt, Daniela [Verfasser]. "Radiofrequenz - induzierte Thermotherapie (RFITT) maligner Lebertumoren - in vitro Evaluierung eines bipolaren/multipolaren Applikationskonzeptes / Daniela Bössenrodt." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1023095130/34.

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17

Roesler, Martin. "Experimentelle Evaluation der Laser-induzierten Thermotherapie (LITT) an ex-vivo Rinderleber unter Verwendung zweier Kühlmedien." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15312.

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ZIEL: In der vorliegenden Studie wurde die Effektivität und Sicherheit der Applikation von 90% Ethanol als Kühlmittel evaluiert METHODEN: Wir benutzten einen Mikrokatheter mit einem äußeren Durchmesser von 1,8 mm, welchen wir in der Rinderleber platzierten. Verbunden mit dem Katheter war ein Dornier Diffusor-Tip H6111-T3 angeschlossen an einen Dornier Medilas Fibertom 5100 Laser. Es wurden zwei Kühlmedien verwendet, physiologische Kochsalzlösung und 90% Ethanol, beide mit einer Flussgeschwindigkeit von 0,75 ml/min und 1,5 ml/min. Fünfzehn Minuten Laserbetriebszeit und verschiedene Wattstärken wurden verwendet. Die Koagulationsgröße wurde makroskopisch ausgewertet. ERGEBNISS: Es konnte kein Unterschied im radialen Durchmesser und in der Form hinsichtlich des verwendeten Kühlmittels gefunden werden. In der Gruppe mit dem hohen Kühlmittelfluss wurde eine Verlängerung des axialen Durchmessers festgestellt. Weiterhin führte die Verwendung von Ethanol zu einer erhöhten Rate an zerstörten Dornier Diffusor-Tips. SCHLUSSFOLGERUNG: Unter diesen technischen Vorraussetzungen wird es keinen Vorteil für die Patienten geben durch die Verwendung von Ethanol. Für bessere Ergebnisse ist ein neues Lichtleitersystem notwendig, welches resistent gegen die Ethanolwirkung ist.<br>Laser-induced thermotherapy of ex-vivo cow liver with open microcatheter system: comparison of two used cooling agents PURPOSE: We evaluated the efficiency and safety of 90% Ethanol as a cooling agent in Laser-induced thermotherapy of the liver. MATERIAL AND METHODS: We used a Microcatheter with an outer diameter of 1.8 mm which was placed in ex-vivo cow liver. Connected to the microcather was a Dornier Diffusor-Tip H6111-T3 coupled to a Dornier Medilas Fibertom 5100 laser. We compared two types of cooling agents, physiological NaCl solution and 90% Ethanol, both with a flow of 0,75 ml/min and 1,5 ml/min. Fifteen minutes of ablation time and different laser powers were used. The lesions size was examined macroscopically. RESULTS: We were not able to find any difference in form or diameter of the ablated liver depending on the usage of NaCL and Ethanol as cooling agent. However utilization of Ethanol yielded a larger length of ablated liver in the high flow group. Furthermore usage of Ethanol results in a higher rate of destructed Dornier Diffusor-Tips. CONCLUSIONS: Under the present technical conditions there will be no benefit from the usage of Ethanol as cooling agent. For better results a new light guide system is needed, which is resistent to the effect of Ethanol.
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18

Aoukal, Samir [Verfasser]. "Effektivität der laserinduzierten Thermotherapie von primären und sekundären hepatischen Tumoren : eine retrospektive klinische Studie / Samir Aoukal." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/102282421X/34.

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19

Pelz, Jörg. "Die Laserinduzierte Thermotherapie (LITT) zur Behandlung von Lebermetastasen - Kombinationstherapie mit Varianten der selektiven/passageren Gefässokklusion der Leber eine experimentelle Studie /." [S.l.] : [s.n.], 2002. http://www.diss.fu-berlin.de/2002/236/index.html.

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20

Raguse, Jan D. [Verfasser]. "Evaluation neuer Strategien in der Therapie lokal fortgeschrittener Plattenepithelkarzinome der Mundhöhle mit der radiofrequenzinduzierten interstitiellen Thermotherapie (RFITT) / Jan D Raguse." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1075493722/34.

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Raguse, Jan [Verfasser]. "Evaluation neuer Strategien in der Therapie lokal fortgeschrittener Plattenepithelkarzinome der Mundhöhle mit der radiofrequenzinduzierten interstitiellen Thermotherapie (RFITT) / Jan D Raguse." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://nbn-resolving.de/urn:nbn:de:kobv:188-fudissthesis000000100006-3.

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22

Johannsen, Manfred [Verfasser]. "Thermotherapie des Prostatakarzinoms unter Verwendung magnetischer Nanopartikel : Präklinische und klinische Evaluation der hermotherapie des Prostatakarzinoms unter Verwendung magnetischer Nanopartikel / Manfred Johannsen." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1022761838/34.

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23

Ayubi, Nawid. "mRNA-Expression vom connective tissue growth factor (CTGF) und hepatocyt growth factor (HGF) nach laserinduzierter Thermotherapie (LITT) und chirurgischer Resektion experimenteller Lebermetastasen." [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/183/index.html.

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Grabig, Anja [Verfasser], A. [Gutachter] Dignaß, C. [Gutachter] Stroszczynski, and M. [Gutachter] Düx. "Magnetresonanztomographisch gestützte laserinduzierte Thermotherapie am Pankreas des Schweins in vivo mit histopathologischer Korrelation / Anja Grabig ; Gutachter: A. Dignaß, C. Stroszczynski, M. Düx." Berlin : Humboldt-Universität zu Berlin, 2006. http://d-nb.info/1208076434/34.

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Proksch, Janina [Verfasser], Michael [Akademischer Betreuer] Kirsch, Michael [Gutachter] Kirsch, and Christian [Gutachter] Stroszczynski. "Langzeitergebnisse und beeinflussende Faktoren nach der Laserinduzierten Thermotherapie (LITT) hepatischer Metastasen kolorektaler Karzinome / Janina Proksch ; Gutachter: Michael Kirsch, Christian Stroszczynski ; Betreuer: Michael Kirsch." Greifswald : Universität Greifswald, 2019. http://d-nb.info/1198402393/34.

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Leidenberger, Tilman Albert Ulrich [Verfasser]. "MR-gesteuerte perkutane intradiskale Thermotherapie (MRgPIT) im offenen 1.0 Tesla MRT : Evaluierung einer innovativen Methode zur Behandlung degenerativer Bandscheibenerkrankungen / Tilman Albert Ulrich Leidenberger." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1067098933/34.

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Proksch, Janina Verfasser], Michael [Akademischer Betreuer] Kirsch, Michael [Gutachter] Kirsch, and Christian [Gutachter] [Stroszczynski. "Langzeitergebnisse und beeinflussende Faktoren nach der Laserinduzierten Thermotherapie (LITT) hepatischer Metastasen kolorektaler Karzinome / Janina Proksch ; Gutachter: Michael Kirsch, Christian Stroszczynski ; Betreuer: Michael Kirsch." Greifswald : Universität Greifswald, 2019. http://nbn-resolving.de/urn:nbn:de:gbv:9-opus-33025.

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Jourdain, Olivier. "Une nouvelle méthode de traitement des fibromes : la thermothérapie interstitielle au laser Nd:Yag : étude préliminaire." Bordeaux 2, 1994. http://www.theses.fr/1994BOR23009.

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Roesler, Martin [Verfasser], C. [Gutachter] Stroszczynski, M. [Gutachter] Düx, and T. [Gutachter] Helmberger. "Experimentelle Evaluation der Laser-induzierten Thermotherapie (LITT) an ex-vivo Rinderleber unter Verwendung zweier Kühlmedien / Martin Roesler ; Gutachter: C. Stroszczynski, M. Düx, T. Helmberger." Berlin : Humboldt-Universität zu Berlin, 2005. http://d-nb.info/1208079980/34.

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Kreft, Gerald. "Erprobung neuer Lasersonden für die laserinduzierte Thermotherapie unter MRT-Kontrolle Korrelation der histologisch gesicherten Nekrose mit der MR-Bildgebung ; Untersuchungen an einem ex-vivo Schweineleber-Modell /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968783384.

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Blenkers, Thomas [Verfasser], Markus [Akademischer Betreuer] Stücker, and Achim [Akademischer Betreuer] Mumme. "Bewertung der endoluminalen bipolaren radiofrequenzinduzierten Thermotherapie (RFITT) bei der Stammvarikosis der Vena saphena magna und der Vena saphena parva / Thomas Blenkers. Gutachter: Markus Stücker ; Achim Mumme." Bochum : Ruhr-Universität Bochum, 2015. http://d-nb.info/1081246596/34.

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Gross, Anja. "Die hochfrequenzinduzierte interstitielle Thermotherapie (HFITT) in bipolarer Technik zur Behandlung von malignen Tumoren im Kopf-Hals-Bereich unter besonderer Berücksichtigung des Oropharynx Applikatorerprobung an In-vitro-Gewebe ; eine experimentelle Studie /." [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/79/index.html.

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Deigner, Tobias [Verfasser]. "Untersuchungen zur systemischen Verteilung von Eisenoxid-Nanopartikeln im Organismus nach intravenöser Applikation sowie zum therapeutischen Effekt von wirkstoffassoziierten Nanopartikeln nach der Thermotherapie im C3H-Mammakarzinom-Modell der Maus / Tobias Deigner." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/104968768X/34.

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34

Lemor, Robert. "Nicht-invasive Kontrolle thermischer Therapien mit Hilfe des Ultraschalls." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2001. http://dx.doi.org/10.18452/14666.

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Bei der Behandlung von Tumoren und Metastasen werden neben der moderaten Hyperthermie auch minimalinvasive, thermotherapeutische Verfahren als Alternativen zur chirurgischen Resektion und / oder zur Unterstützung der Radio- und Chemotherapie angewandt, bei denen das Gewebe lokal begrenzt zur gezielten Zerstörung durch Koagulation auf Temperaturen bis zu 100 °C erhitzt wird. Dabei zeigen besonders die interstitiellen Techniken bei der Behandlung von Lebermetastasen und Prostataerkrankungen vielversprechende Ergebnisse, jedoch steht derzeit neben der Magnetresonanztomographie kein kostengünstiges, routinemäßig einsetzbares Verfahren zur nicht-invasiven on-line Therapiekontrolle zur Verfügung, so daß diese Eingriffe meist "blind", auf anatomische Normwerte und praktische Erfahrungen des Arztes gestützt, durchgeführt werden. In dieser Arbeit werden die Möglichkeiten der nicht-invasiven Ultraschall Kontrolle der Thermotherapien am Beispiel der laserinduzierten interstitiellen Thermotherapie untersucht und zwei Ultraschallverfahren zur Therapiekontrolle vorgeschlagen. Das erste Verfahren basiert auf der Auswertung von lokalen Veränderungen der Laufzeit des Schallsignals zur Ermittelung der Temperaturverteilung im Gewebe. Es beruht physikalisch auf der Temperaturabhängigkeit der Schallgeschwindigkeit. Das zweite Verfahren basiert physikalisch auf den Dämpfungseigenschaften von biologischem Gewebe und deren Abhängigkeit von der Gewebestruktur. Mit diesem Verfahren werden Veränderungen in der Frequenzabhängikeit der Dämpfung quantitativ ausgewertet und somit auf den Gewebezustand geschlossen. Beide Verfahren werden im Hinblick auf den klinischen Einsatz entwickelt und in ein experimentelles System zur Therapiekontrolle implementiert, wobei besonderes Augenmerk auf die Entstehung von Störungen und Artefakten durch Patientenbewegungen gelegt und eine Methode zur Kompensation dieser Bewegungen vorgestellt wird. Anhand von in vitro Experimenten und einer ersten in vivo Messung wird gezeigt, daß beide Verfahren zur Therapiekontrolle von thermischen Therapien in Echtzeit tauglich sind. Sowohl anhand von Temperaturkarten als auch anhand von Strukturkarten kann die Läsionsausbreitung während der Therapie nicht-invasiv ermittelt und dargestellt werden.<br>As alternatives to surgical resection and/or supportive to radio- or chemo-therapy of tumors and metastases minimal invasive thermal treatment procedures besides the moderate hyperthermia are used, by which the tissue is heated up locally to temperatures up to 100 ° C. Particularly the interstitial techniques show promising results with the treatment of liver metastases and prostate cancer. However beside nuclear magnetic resonance tomography there is no economical, by routine applicable procedure for non invasive therapy control at present disposal, so that these interventions are usually executed "blind" by means of anatomical standard values and practical experience of the physician. By the example of the laser induced interstitial thermo-therapy in this work the possibility of non invasive control of thermal therapies by means of ultrasound are evaluated. Two different ultrasonic procedures are proposed for therapy control. The first procedure is based on the analysis of local modifications in the time of flight of the ultrasound signal for determination of the temperature distribution in the tissue. It is based on the physical dependence of the sound velocity on temperature. The second procedure is based on the physical attenuation characteristics of biological tissue and their dependence on the tissue structure. With this procedure changes in the frequency dependence of the ultrasound attenuation are quantitatively analyzed yielding information on the tissue status. Both procedures are developed with regard to the clinical application and are implemented in an experimental system for therapy control, whereby special attention was given to disturbances and artifacts due to patient movement and a method for compensating these movements is presented. With in vitro experiments and a first in vivo measurement it is shown, that both procedures are feasible for real time control of thermal therapies. During the treatment the formation of the therapeutic lesion can be observed and displayed through temperature mapping as well as structural mapping.
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35

Prudhomme, Michel. "Thermothérapie interstitielle par le laser diode dans le traitement des tumeurs hépatiques : étude expérimentale chez le lapin." Montpellier 1, 1995. http://www.theses.fr/1995MON11149.

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36

Prudhomme, Michel. "Traitement des tumeurs hépatiques par thermothérapie interstitielle induite par le laser diode." Montpellier 1, 2000. http://www.theses.fr/2000MON1T020.

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37

Wiryaatmadja, Edwina. "Evaluation of nanoparticles-based thermotherapy for cancer." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/42152.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.<br>Includes bibliographical references (p. 83-88).<br>Under alternating magnetic field, superparamagnetic iron oxide nanoparticles can be used to generate heat for the treatment of cancer. With suitable coating, these nanoparticles are biocompatible, stable in solution, and absorbed by tumor cells in good contrast. The mechanism of heating is mainly due to Neel relaxation process and a quantity called specific loss power (SLP) / specific absorption rate (SAR) is used to describe the heating effect. Past clinical studies have shown minimum side effects and proven the success of the new thermotherapy as a treatment modality in conjunction with chemo- or radiotherapy. Studies are in progress to improve the nanoparticles' heating power to enable treatment of small tumors and metastases, thermoablation as a monotherapy, and to achieve tumor-specific thermotherapy with the aid of tumor-finding molecules. This paper evaluates the novel technology that is magnetic nanoparticles-based thermotherapy and explores its commercialization potential. It explains the medical need driving the innovation, examines the technology in comparison with existing cancer therapies, identifies the strategic position the technology has in the present state of market for cancer therapies, and explores opportunities and Challenges in the introduction of the new therapy into the U.S. market.<br>by Edwina Wiryaatmadja.<br>M.Eng.
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38

Billard, Bonnie Elizabeth 1964. "A theoretical and experimental study of the feasibility of high temperature ultrasound hyperthermia." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/276971.

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The purpose of this research was to investigate the feasibility of using high temperature ultrasonic pulses to administer therapeutic hyperthermia treatments independent of changes in blood perfusion and tissue properties. The use of a computer simulation program was used to study the effects of blood perfusion, tissue properties, transducer characteristics, and treatment geometry on the temperature elevation and thermal dose delivered by short high temperature ultrasonic pulses. Experiments were conducted in vitro and in vivo to investigate the effects of blood perfusion changes. Other experiments were carried out in dog thigh muscle to determine the effects of changes in tissue properties. A final study was done where murine melanoma in mice were treated with high temperature ultrasound. Results show that shorter pulse lengths (≤ 2 s) and smaller focal diameters (≤ 3 mm) give practically perfusion independent temperature elevation and thermal dose. Normal fluctuations in tissue properties should not have a significant effect on the treatment provided that proper choice of transducer is made for each individual application. High temperature ultrasonic pulses have also been shown to induce tumor responses. Based on this research, this technique is a feasible means of administering hyperthermia for cancer therapy.
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39

Kress, Reid Leonard. "Adaptive model-following control for hyperthermia treatment systems." Diss., The University of Arizona, 1988. http://hdl.handle.net/10150/184430.

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The purpose of this research was to develop three real-time adaptive temperature controllers for hyperthermia heating systems. Each scheme is made adaptive by using a transient Gaussian estimation routine to estimate the tissue blood perfusion and by then using these estimated values either in an optimizing routine, or in an observer, or in both. The optimizing routine uses a steady-state Gaussian estimation technique to optimize the power distribution until the best possible match is obtained between the steady-state temperatures predicted by a treatment model and a prespecified ideal temperature distribution. The observer uses a treatment model to control unmeasured locations. The first adaptive control scheme uses the optimizing routine alone, the second uses the observer alone and the third uses both the optimzing routine and observer. The performance of each of the adaptive control schemes is compared to a standard proportional-integral-derivative (PID) control scheme for one-dimensional simulations of typical treatments. Results comparing the deviation of the controlled temperature distribution to the ideal desired temperature distribution for all locations and all times indicate that the adaptive schemes perform better than the PID scheme. It can be concluded that adaptive control yields improved performance if good a priori knowledge of the treated region tissue and perfusion region boundaries is available. While these control schemes were designed for eventual implementation on a scanned focused ultrasound hyperthermia treatment system, the techniques are applicable to any system with the capability to vary specific power with respect to location and with an unknown distributed energy sink proportional to the temperature elevation.
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40

Haider, Shah Ali 1954. "Ferromagnetic implants in hyperthermia: An analytical, numerical and experimental study." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/291608.

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Power deposition in ferromagnetic implants of cylindrical and spherical shape from an externally applied uniform time harmonic radio-frequency magnetic field has been investigated by means of quasi-static analysis. Inductive heating efficiency is related to the relative permeability and temperature dependence of permeability can be exploited to limit the maximum temperature rise to the desired value by proper choice of Curie point of ferromagnetic material. It is found that theoretically calculated power absorption versus orientation of the cylindrical implant with the direction of magnetic field is in good agreement with the experimental results. The parametric studies are based on a two-dimensional finite difference model for calculating temperature distribution in perfused tissues due to induction heating of an array of implants. An approximate analytical model was developed for a large regular array of implants in perfused tissues. The results of the analytical model are compared with those of the numerical model. (Abstract shortened with permission of author.)
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41

Olsrud, Johan. "Physical aspects of thermotherapy a study of heat transport with a view to treatment optimisation /." Lund, Sweden : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/57455676.html.

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42

Maier, Florian [Verfasser], and R. [Akademischer Betreuer] Dillmann. "Magnetresonanzbildgebung zur Führung und Überwachung minimalinvasiver Thermotherapien / Florian Maier. Betreuer: R. Dillmann." Karlsruhe : KIT-Bibliothek, 2012. http://d-nb.info/1033351512/34.

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43

Bell, Gavin S. "Developments of iron oxide nanoparticles for magnetic thermotherapy and multimodal imaging." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10055094/.

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Current methods of cancer therapy and detection still warrant high demand and great developments. Utilising the fundamental magnetism of iron oxide nanoparticles, it is possible to harness that magnetic power for the development of new, influential therapeutic and imaging modalities. In this thesis, a detailed look into the use of iron oxide nanoparticles as a material for magnetic thermotherapy and bio-imaging will be undertaken. Iron oxide nanoparticles are synthesised using a common co-precipitation synthesis. Stabilisation was achieved with citrate molecules followed by advanced functionalisation of the nanomaterial with gold achieved via reduction of Au3+ (HAuCl4) to Au0 from the citrate ligands. These materials were shown to exhibit remarkable intrinsic heating power when under the influence of an external alternating current magnetic field. Following the potential of iron oxide nanoparticles functionalised with gold for magnetic hyperthermia, multimodal imaging and therapeutic probes were studied. Iron oxide gold nano were analysed as possible Raman enhancer substrates. Finally, iron oxide nanoparticles were synthesised using an organic photoacoustic dye as a stabilising ligand to functionalise the magnetic Fe3O4 cores with optical properties. This lead to the novel co-precipitation synthesis of indocyanine green (ICG) and Flamma®774 covalently attached to Fe3O4 nanoparticles.
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44

Buechler, Dale Norman 1962. "MAGNETIC INDUCTION HEATING OF FERROMAGNETIC IMPLANTS FOR HYPERTHERMIC TREATMENTS OF CANCER." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276376.

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45

Hallin, Anders. "Transurethral microwave thermotherapy of benign prostatic hyperplasia : a clinical and methodological evaluation /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2727-8.

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46

Ng, Kwok-chai Kelvin, and 吳國際. "Clinical applications of radiofrequency ablation for hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557674.

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47

Ross, Michael Paul 1963. "Evaluation of a two-dimensional electromagnetic model for hyperthermia treatment planning." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276780.

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A series of hyperthermic, static, torso phantom experiments have been performed. The results are presented in comparison to a two-dimensional, theoretical, electromagnetic model. The 2-D model is assessed for potential use in clinical plannings and evaluations. Included in the assay of this model are comparisons of actual clinical patient data. Theoretically calculated electromagnetic fields and temperatures are obtained using a finite element numerical method (FEM) based on weighted residuals. Two experimental methods of extracting energy deposition data are discussed and utilized: (1) by measuring temperature differentials to calculate specific absorption rates (SAR), and (2) by measuring the square of the E-field directly which relates proportionally to the absorbed power. The employed regional heat source is an annular phased array (APA) operating at 70 MHz. The outcome of the assessment suggests that the results can be quantitative for simple heterogeneous phantom problems, but remain qualitative for clinical evaluative purposes.
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48

Emch, Samantha. "Thermotherapeutic enhancement of infusate distribution during convection enhanced delivery in the brain using fiber-optic microneedle devices." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/51954.

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Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults and has a median survival of 13.4 months. Convection enhanced delivery (CED) has shown promise for the treatment of GBM by allowing intratumoral delivery of therapeutics, bypassing the blood brain barrier. A fiberoptic microneedle device (FMD) CED catheter enables simultaneous delivery of laser energy and therapeutic. The laser allows for heating of tissue in the region of infusion, called thermotherapy. Thermotherapy offers the advantages of increasing the volume of distribution (Vd) of the infusate, as well as facilitating intracellular penetration of the therapeutic. We hypothesize that heating of brain tissue will increase infusate Vd in ex vivo CED brain infusions. Methods: Formalin fixed mouse brains were infused by FMD-CED with Evans blue for 1 hour at 0.1 μl/min, at 22°C, 37°C and 42°C (n=4 brains/group). The Vd was determined and compared using one-way ANOVA. Results: FMD-CED performed at 42°C resulted in significantly higher mean Vd (4.90+2.2mm3; p =0.03) than those at 22°C (1.49+0.4 mm3), although no differences in Vd were observed between the other temperature groups. 42°C brains demonstrated interstitial and intracellular distribution, while rare intracellular distribution was noted in the other groups. Discussion: The Vd of FMD-CED infusions is facilitated by sub-lethal thermotherapy. This study indicates that thermotherapeutic enhancement of infusate Vd does not occur exclusively via vascular mechanisms. Thermotherapy facilitates advective-diffusion by decreasing interstitial fluid pressure and increasing transcellular fluid transport. These results were validated in a companion in vivo FMD-CED study in the rodent brain.<br>Master of Science
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49

Clegg, Scott Tom. "Estimation of three-dimensional temperature fields from a limited number of transient temperature measurements during hyperthermia." Diss., The University of Arizona, 1988. http://hdl.handle.net/10150/184424.

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In this dissertation, a new reconstruction algorithm to estimate the complete temperature field during hyperthermia is developed which relies upon a limited amount of transient measured temperature data. The predictive capabilities of this new algorithm are then systematically studied; first using one-dimensional simulated treatments, then using three-dimensional simulated treatments, and finally applying it to hyperthermia treatments of normal canine thighs. It was found that this new algorithm predicts the complete temperature fields more accurately and robustly than the steady-state approach. In particular, it can better predict the complete temperature fields in situations where the number of unknown blood perfusion parameters are greater than the number of available temperature sensors. It was also found that the steady-state temperature field could be estimated to within 1°C if there was no measurement noise, no model mismatch, and as few as three measurement locations for seven perfusion zones. The addition of measurement noise degraded the performance of this estimation algorithm especially when the number of measurement locations was small. It was found that use of Tikhonov regularization of order zero significantly improved the performance of the algorithm and that there was an optimal choice for the regularization parameter. For the animal experiments, normal canine thighs were instrumented with one-hundred twelve thermocouples and heated to steady-state using a 6 cm planar ultrasound transducer operating at 0.5 MHz: then the power was turned off and the transient cool down temperature data was stored for later use by the reconstruction algorithm. Only a subset of the one-hundred twelve measurements was used as input to the reconstruction algorithm. The remaining measurements were used to compare the results of the reconstruction algorithm with the true temperatures. The results showed that in general the predicted perfusion and reconstructed temperature field did not change significantly as sensors were removed. However, the error was quite large for some of the situations studied particularly when only twenty-seven piecewise constant regions of perfusion were used. Increasing the number of perfusion regions reduced this error suggesting that model mismatch had contributed significantly to the error.
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Lim, Junghwan 1961. "Evaluation of temperature fields in two dynamic phantoms heated by the ferromagnetic implant hyperthermia." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276908.

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Two experimental dynamic phantoms have been used for studying temperature distributions induced by interstitial ferromagnetic implant hyperthermia at various blood perfusions, Curie point implants, and input power levels. One of the phantoms is an axially perfused hollow cylinder filled with 3 mm diameter glass beads, and the other is a similar cylinder model that is radially perfused. Analytic models have been developed for evaluating temperature profiles within the two phantoms. Experimental results from the phantoms compare reasonably well with the analytical results. A qualitative comparison is made between thermal profiles derived from both a convection energy equation, for a homogeneous porous medium, and a bioheat transfer equation. The adequacy of using a porous material for simulating living tissue is discussed. Parametric studies showing the effects of various implant parameters such as Curie point and applied power are analyzed.
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