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Journal articles on the topic 'These compounds showed mild to moderate antibacterial activity against Gram positive as well as Gram negative bacteria'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Mohd., Imran*. "ANTIMICROBIAL ACTIVITY EVALUATION OF SOME (Z)-2- (2-OXO-1-((ARYLAMINO)METHYL)INDOLIN-3-YLIDENE)-N- (4-(2-OXO-2H-CHROMEN-3-YL)THIAZOL-2-YL)HYDRAZINE- 1-CARBOXAMIDES." Indo American Journal of Pharmaceutical Sciences (IAJPS) 03, no. 09 (2016): 988–895. https://doi.org/10.5281/zenodo.154116.

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Fourteen(Z)-2-(2-oxo-1-((arylamino)methyl)indolin-3-ylidene)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2 yl)hydrazine-1-carboxamides 4a-4n were prepared by treating (Z)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)-2-(2- oxoindolin-3-ylidene)hydrazine-1-carboxamide 3 with the aryl amines and formaldehyde. The chemical structures of these compounds were elucidated by their physical constants, spectral data and elemental analysis. These compounds were investigated for their antimicrobial activity against five Gram-positive bacteria, namely, S. aureus, E. faecalis, S. epidermidis, B. subtilis and B. cereus

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Gosavi, Seema A., Dattatray H. Nandal, and Sarita S. Pawar. "Synthesis and Biological Evaluation of Some Novel Mannich Bases of Isoxazoline Derivatives as Possible Antimicrobial Agents." Asian Journal of Chemistry 31, no. 12 (2019): 2821–26. http://dx.doi.org/10.14233/ajchem.2019.22247.

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Novel isoxazoline derivatives were synthesized by condensation of substituted acetophenones with aldehyde in presence of alcoholic NaOH to get intermediate chalcones, which were further treated with hydroxylamine hydrochloride in presence of sodium hydroxide to get isoxazoline derivatives. The latter were refluxed separately with isonicotinic acid hydrazide and sulphanilamide in presence of formaldehyde for 6-10 h to afford corresponding Mannich bases. The structures of synthesized compounds were established on the basis of melting point, TLC, IR, 1H NMR and HRMS. Antimycobacterial activity of

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3

Richa, Kothari. "Synthesis of Nickel (II) Schiff Base Molecular Adducts: Spectroscopic Characterization & Antioxidant activity." American Journal of PharmTech Research 12, no. 06 (2022): 124–41. https://doi.org/10.5281/zenodo.7479291.

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ABSTRACT Transition metal complexes of Ni (II) with schiff base ligand (HL) derived from condensation of 3-Bromo benzaldehyde and hydrazine monohydrate were successfully synthesized , characterized and isolated .The schiff base ligand and its Ni(II) complexes prepared were characterized by melting  point /decomposition temperature, solubility, conductivity/ Molar conductance, UV- visible, FT-IR, XRD, TGA and elemental analysis results. In the UV-Vis study, a bathochromic shift of approximately 60 nm indicating the formation of coordinated Ni(II) complexes by more than one coordinating sit

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Mustafa M. AL-Hakiem, Rita S. Elias, and Munther A. Mohammed-Ali. "Synthesis, characterization and antibacterial evaluation of some sulfonamide Schiff base derivatives." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (2019): 3535–43. http://dx.doi.org/10.26452/ijrps.v10i4.1729.

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New series of Schiff base compounds obtained from sulfa drugs have been synthesized by the reaction of sulfonamide compounds (sulfadiazine, sulfapyridine, sulfamethazine, or sulfamerazine) with corresponding aromatic aldehydes (3-pyridinecarboxaldehyde or 4-pyridinecarboxaldehyde). The synthesized compounds were characterized by FT-IR, ESI-Mass, and 1H-NMR spectroscopy to confirm the chemical structures of synthesized compounds. The purity of all synthesized compounds were verified using pre-coated TLC (MERCK) plates using dichloromethane: methanol (9:1) solvent system. The chromatographic pla

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5

Ranjbar-Karimi, Reza, and Alireza Poorfreidoni. "Incorporation of Fluorinated Pyridine in the Side Chain of 4-Aminoquinolines: Synthesis, Characterization and Antibacterial Activity." Drug Research 68, no. 01 (2017): 17–22. http://dx.doi.org/10.1055/s-0043-116674.

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AbstractA series of hybrid of 4-aminoquinoline and fluorinated pyridine derivatives were synthesized and their chemical structure were confirmed by 19F-NMR, 1H-NMR, 13C-NMR and FT-IR. All compounds were tested against one Gram-positive and one Gram-negative bacteria to assess their in vitro antibacterial activity. Compounds 10a, 10b, 11a and 12b showed moderate antibacterial activity against Gram-positive bacterium, Staphylococcus aureus.

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Abdillah, Latifah Ningrum, Dwi Suryanto, Kiki Nurtjahja, and Jendri Mamangkey. "Preliminary Study on Potential Bacterial Species Introducing Antibacterial Agent from Sponge in Unggeh Island Central Tapanuli, Indonesia." Jurnal Penelitian Pendidikan IPA 10, no. 7 (2024): 3780–86. http://dx.doi.org/10.29303/jppipa.v10i7.8264.

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Sponges have the potential to symbiont with bacteria that produce antibacterial compounds. This study was conducted to isolate and test the antibacterial activity of sponge symbiont bacteria. Bacterial isolates obtained were tested for antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli using the Kirby-Bauer method. The identification results of both sponges have similarities with Clathria sp. and Hyrtios sp. symbiont bacteria obtained from both sponges as many as 16 isolates. Antibacterial activity testing had a weak inhibitory effect on isolates Sp1A,

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7

Vergoz, Delphine, Flore Nilly, Florie Desriac, et al. "6-Polyaminosteroid Squalamine Analogues Display Antibacterial Activity against Resistant Pathogens." International Journal of Molecular Sciences 24, no. 10 (2023): 8568. http://dx.doi.org/10.3390/ijms24108568.

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A series of 6-polyaminosteroid analogues of squalamine were synthesized with moderate to good yields and evaluated for their in vitro antimicrobial properties against both susceptible and resistant Gram-positive (vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus) and Gram-negative (carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa) bacterial strains. Minimum inhibitory concentrations against Gram-positive bacteria ranged from 4 to 16 µg/mL for the most effective compounds, 4k and 4n, and showed an additive or synergistic effect with

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8

KOONA, Saradhajyothi, and Subbarao BUDIDA. "Antibacterial Potential of the Extracts of the Leaves of Azadirachta indica Linn." Notulae Scientia Biologicae 3, no. 1 (2011): 65–69. http://dx.doi.org/10.15835/nsb315470.

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Azadirachta indica A. Juss (syn. Melia azadirachta) is well known in India and popularly known as Indian neem. To evaluate antibacterial potential, the agar well diffusion assay was used against Gram-negative and Gram-positive bacteria. Penicillin and Dimethyl sulfoxide were used as positive and negative controls, respectively. Methanol extract showed the highest and chloroform extract showed moderate to good antibacterial activity. Proteus vulgaris and Micrococcus luteus were the most susceptible bacteria while Bacillus subtilis was more resistant bacterium to the hexane, chloroform and metha

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9

Qu, Tengfei, Lailiang Qu, Xiaoguang Wang, et al. "Design, synthesis, and antibacterial activity of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety." Zeitschrift für Naturforschung C 73, no. 3-4 (2018): 117–22. http://dx.doi.org/10.1515/znc-2017-0063.

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AbstractA series of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety was designed and synthesized by using an active substructure combination method. Then, the antibacterial activities of all the target compounds were evaluated in vitro against three Gram-positive bacteria and three Gram-negative bacteria. The antibacterial assay showed that some target compounds displayed moderate to good antibacterial efficacy in comparison with the reference drug Chloromycin. Some interesting results of structure-activity relationships were also discussed.

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Abd Alhameed, Rakia, Zainab Almarhoon, Sarah I. Bukhari, Ayman El-Faham, Beatriz G. de la Torre, and Fernando Albericio. "Synthesis and Antimicrobial Activity of a New Series of Thiazolidine-2,4-diones Carboxamide and Amino Acid Derivatives." Molecules 25, no. 1 (2019): 105. http://dx.doi.org/10.3390/molecules25010105.

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Novel thiazolidine-2,4-dione carboxamide and amino acid derivatives were synthesized in excellent yield using OxymaPure/N,N′-diisopropylcarbodimide coupling methodology and were characterized by chromatographic and spectrometric methods, and elemental analysis. The antimicrobial and antifungal activity of these derivatives was evaluated against two Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), two-Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and one fungal isolate (Candida albicans). Interestingly, several samples demonstrated weak to moderate a

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Kottakki, Naveen K., and Amperayani K. Rao. "SYNTHESIS OF PIPERINE - PIPERAZINE ANALOGUES AND THEIR ANTIBACTERIAL ACTIVITY." INDIAN DRUGS 58, no. 06 (2021): 30–35. http://dx.doi.org/10.53879/id.58.06.12311.

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In the current study, a series of piperine – piperazine analogues (5a to 5f) were designed and synthesized. The piperine was isolated from pepper and used for the conjugation with heterocyclic moiety for better biological activity. The piperazine heterocyclic was chosen for conjugation with piperine. The newly synthesized structures were determined by IR, 1H NMR and 13C NMR spectral data. The compounds were examined for their anti‐microbial activity against gram-positive (Bacillus subtilis) and gram-negative (Vibrio cholerae) bacteria using the agar well diffusion method. The newly synthesized

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Mahdi, Monther Faisal, Ali Hussein Alwan, and Shahlaa Zuhair Abdul-Majeed. "Synthesis, CharacterizationandAntibacterial Studyof NewSulfa Drug Derivatives Containing 4-Thaiazoliodinones." Al Mustansiriyah Journal of Pharmaceutical Sciences 17, no. 1 (2018): 11. http://dx.doi.org/10.32947/ajps.v17i1.58.

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New series of sulfamethoxazole containing -4-thiazolidinone ring (compounds IV(a-f)) have been synthesized and evaluated for their antibacterial activity against gram positive bacteria & gram negative bacteria. These compounds expected to have higher antibacterial activity than sulfamethoxazole, due to the presence of 4-thiazolidinone pharmacophore.The purity of the synthesized compounds was detected by determination of physical properties (melting points &Rf values). The chemical structure of the intermediate and final compounds was characterized and confirmed by measuring FT-IR spect

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Mishra, Preeti, Anita Sha, Poulami Bhakat, Sudipta Mondal, and Animesh Kumar Mohapatra. "Antibacterial activity assessment of petroleum ether and methanolic extracts of Achyranthes aspera Linn (Amaranthaceae)." Journal of Applied and Natural Science 12, no. 3 (2020): 354–64. http://dx.doi.org/10.31018/jans.v12i3.2319.

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Achyranthus aspera is a common weed and known for various medicinal properties. The aim of the present study was to evaluate the antibacterial activities of different concentrations of methanolic and petroleum-ether leaf extracts of A. aspera against three gram-positive bacteria (Micrococcus luteus, Bacillus subtilis, Streptococcus mitis) and six gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Salmonella typhi, Salmonella paratyphi A (MTCC-3220), Shigella flexneri). The phytochemical screening of the leaf extract of the herb indicated the presence of fla

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Ismaeel, Sarah S., Monther F. Mahdi, and Basma M. Abd Razik. "Molecular Drug Design, Synthesis and Antibacterial study of Novel 4-Oxothiazolidin-3-yl Derivatives." Al Mustansiriyah Journal of Pharmaceutical Sciences 20, no. 2 (2020): 1–10. http://dx.doi.org/10.32947/ajps.v20i2.691.

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New compounds containing 4-thiazolidinone pharmacophore 5(a) and (5b) have been synthesized. The chemical structures of the intermediate and final compounds were characterized and confirmed by using FT-IR and 1H-NMR spectroscopy. All final compounds were tested against gram-positive and gram-negative bacteria using a well-diffusion technique for their ability as antimicrobial agents. The tested compounds 5a and 5b showed variable and modest antibacterial activity against gram-negative bacteria and gram-positive bacteria. Molecular docking simulations were studied to understand the molecular co

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15

Dziduch, Katarzyna, Sara Janowska, Sylwia Andrzejczuk, et al. "Synthesis and Biological Evaluation of New Compounds with Nitroimidazole Moiety." Molecules 29, no. 13 (2024): 3023. http://dx.doi.org/10.3390/molecules29133023.

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Heterocyclic compounds, particularly those containing azole rings, have shown extensive biological activity, including anticancer, antibacterial, and antifungal properties. Among these, the imidazole ring stands out due to its diverse therapeutic potential. In the presented study, we designed and synthesized a series of imidazole derivatives to identify compounds with high biological potential. We focused on two groups: thiosemicarbazide derivatives and hydrazone derivatives. We synthesized these compounds using conventional methods and confirmed their structures via nuclear magnetic resonance

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16

Shakir, Raied Mustafa, Shaimaa Abed Saoud, and Dhuha Faruk Hussain. "Synthesis, Antibacterial, and Molecular Docking Study of Novel 2-Chloro-8-Methoxy-3-Aryl-[1,3] Benzoxazine Derivatives using Vilsmeier Reagent." International Journal of Drug Delivery Technology 10, no. 03 (2020): 487–98. http://dx.doi.org/10.25258/ijddt.10.3.32.

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Reducing of ethyl 4-((2-hydroxy-3-methoxybenzylidene)amino)benzoate (1) afford ethyl 4-((2-hydroxy-3-methoxybenzyl)amino)benzoate (2). Reaction of this compound with Vilsmeier reagent affords novel 2-chloro-[1,3] benzoxazine ring (3). The corresponding acid hydrazide of compound 3 was synthesized from reaction of compound (3) with hydrazine hydrate. Newly series of hydrazones (5a–i) were synthesized from reaction of acid hydrazide with various aryl aldehydes. Antibacterial activity of the hydrazones was secerned utilizing gram-negative and gram-positive bacteria. Compound (5b) and (5c) exhibit

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17

Mazen Mohammed Jwaid, Karima Fadhil Ali, and Mayada Hadi Abd-alwahab. "Synthesis, Antibacterial study and ADME Evaluation of Novel Isonicotinoyl Hydrazide Derivative Containing 1,3,4-Oxadiazole Moiety." Al Mustansiriyah Journal of Pharmaceutical Sciences 20, no. 4 (2022): 113–21. http://dx.doi.org/10.32947/ajps.v20i4.781.

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Novel derivative of isoniazid containing 1,3,4-oxadiazole pharmacophore has been synthesized. The chemical structure of the compound was characterized and confirmed by using FT-IR and 1H-NMR spectroscopy.  The desired compound was tested against gram-positive and gram-negative bacteria using agar well-diffusion technique for their ability as antibacterial agent and showed good antibacterial activity against gram-negative bacteria and gram-positive bacteria. In addition, ADME evaluations were performed using Swiss ADME to predict if the synthesized compound can be given orally, the

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18

Althobiti, Hanan A., and Sami A. Zabin. "New Schiff bases of 2-(quinolin-8-yloxy)acetohydrazide and their Cu(ii), and Zn(ii) metal complexes: their in vitro antimicrobial potentials and in silico physicochemical and pharmacokinetics properties." Open Chemistry 18, no. 1 (2020): 591–607. http://dx.doi.org/10.1515/chem-2020-0085.

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AbstractThe purpose of this work was to prepare Schiff base ligands containing quinoline moiety and using them for preparing Cu(ii) and Zn(ii) complexes. Four bidentate Schiff base ligands (SL1–SL4) with quinoline hydrazine scaffold and a series of mononuclear Cu(ii) and Zn(ii) complexes were successfully prepared and characterized. The in vitro antibacterial and antifungal potential experimentation revealed that the ligands exhibited moderate antibacterial activity against the Gram-positive bacterial types and were inactive against the Gram-negative bacteria and the fungus strains. The metal

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Sulaiman, Ahmed T., and Susan W. Sarsam. "Synthesis, Characterization and Antibacterial Activity Evaluation of New Indole-Based Derivatives." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 29, no. 1 (2020): 207–2015. http://dx.doi.org/10.31351/vol29iss1pp207-2015.

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A new series of N-acyl hydrazones (4a-g) derived from indole-3-propionic acid (IPA) were synthesized. These N-acyl hydrazones were prepared by the reaction of 3-(1H-indol-3-yl) propane hydrazide and aldehyde in the existence of glacial acetic acid as a catalyst. 1HNMR and FT-IR analyses were used to identify the synthesized compounds and they were in vitro evaluated as antibacterial agents against six different types of microorganisms by using well diffusion method. All the tested N-acyl hydrazones (4a-g) displayed moderate activity against the Gram-negative E.coli, comparable to that of Amoxi

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20

Venkateshappa, G., P. Raghavendra Kumar, and Krishna2. "Synthesis, Characterization and Antimicrobial Activity of N-2-(4-Chlorophenyl)acetyl Derivatives of (S)-Amino Acids." Asian Journal of Chemistry 32, no. 2 (2019): 381–84. http://dx.doi.org/10.14233/ajchem.2020.22416.

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This paper reports the synthesis, characterization and antibacterial activity of N-2-(4-chlorophenyl)acetyl derivatives of various (S)-amino acids such as (S)-alanine, (S)-phenylalanine, (S)-leucine, (S)-methionine, (S)-proline and (S)-tryptophane. These compounds have been successfully synthesized and their structures were confirmed by 1H NMR and 13C NMR and FT-IR spectroscopy. The antimicrobial activity of these six (S)-amino acids derivatives have been evaluated by the agar well diffusion method against pathogens both Gram-positive (S. aureus) and Gram-negative (K. aerogenes, E. coli and P.

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Kouhkan, Maryam, Fatemeh Ghanbary, and Fatemeh Karimi. "Antibacterial Activity of New Compounds Based on Nanocomposites." Avicenna Journal of Clinical Microbiology and Infection 8, no. 3 (2021): 94–97. http://dx.doi.org/10.34172/ajcmi.2021.17.

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Background: Antimicrobial resistance is a major problem in treatment and public health, and it has been increasing over the last few decades. Hence, serious measurements are needed to overcome this challenge. In this study, we evaluated antibacterial and antifungal activity of some nanocomposites including titanium dioxide (5a), polyimide nanocomposites containing cerium oxide (5b), silver-titanium dioxide nanoparticles prepared under desired conditions (5c), polyaniline/wheat husk ash PANI /WHA (5d), Ag-TiO2 prepared by sol–gel route (5e), and cellulose-graphene (5f) against some bacterial an

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Amri, Indah, Purnaning Isnaeni, and Jasni Sabri. "<b><i>In vitro</i> evaluation of the antimicrobial efficacy of <i>Eupatorium odoratum</i> ethanol extract against Gram-positive and Gram-negative bacterial strains </b>." Open Veterinary Journal 14, no. 11 (2024): 3100. https://doi.org/10.5455/ovj.2024.v14.i11.39.

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<b>Background: </b> Eupatorium odoratum L (Siam weed) is a highly invasive species that contains various beneficial active compounds. This study was conducted to explore the antibacterial properties of E. odoratum ethanol extract against gram-positive and gram-negative bacteria. <b>Aim: </b> The aim of this study was to evaluate the antibacterial activity of E. odoratum ethanolic extract against various gram-positive and gram-negative bacteria to assess its potential as an antimicrobial agent. <b>Methods: </b> The study employed the agar well diffusion metho

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Kaur, Jagwinder, Meenakshi Malhotra, Ajeet Pal Singh, and Amar Pal Singh. "Evaluation of Anti-Bacterial Activity of Turnip Green Leaves Extracts." Journal of Drug Delivery and Therapeutics 14, no. 12 (2024): 117–22. https://doi.org/10.22270/jddt.v14i12.6554.

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The study aimed to assess the antimicrobial potential of aqueous and methanolic extracts from Brassica rapa L. leaves. Phytochemical analysis revealed the presence of various compounds including carbohydrates, fats, proteins, vitamins, minerals, electrolytes, sugars, soluble and insoluble fiber, and amino acids. Both extracts were evaluated for antibacterial activity against six microorganisms, including gram-positive and gram-negative bacteria, compared with the standard antibiotic Gentamycin. Methanolic extract exhibited higher antibacterial efficacy against gram-positive bacteria compared t

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Le, Tam Minh, Thu Huynh, Fatima Zahra Bamou, András Szekeres, Ferenc Fülöp, and Zsolt Szakonyi. "Novel (+)-Neoisopulegol-Based O-Benzyl Derivatives as Antimicrobial Agents." International Journal of Molecular Sciences 22, no. 11 (2021): 5626. http://dx.doi.org/10.3390/ijms22115626.

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Discovery of novel antibacterial agents with new structures, which combat pathogens is an urgent task. In this study, a new library of (+)-neoisopulegol-based O-benzyl derivatives of aminodiols and aminotriols was designed and synthesized, and their antimicrobial activity against different bacterial and fungal strains were evaluated. The results showed that this new series of synthetic O-benzyl compounds exhibit potent antimicrobial activity. Di-O-benzyl derivatives showed high activity against Gram-positive bacteria and fungi, but moderate activity against Gram-negative bacteria. Therefore, t

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K.K., Sivakumar, Rajalakshmi G, and Rajasekaran A. "Synthesis, characterization and biological evaluation of Schiff bases of 5-amino-4-[2-(4-nitro-1,3-benzothiazol-2 yl)hydrazinylidene]-2,4-dihydro- 3H-pyrazol-3-one derivatives." International Journal of Drug Design and Discovery 3, no. 4 (2025): 886–97. https://doi.org/10.37285/ijddd.3.4.2.

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In the present work totally 12 Schiff bases of 5-amino-4-[2-(4-nitro-1,3-benzothiazol-2 yl)hydrazinylidene]-2,4-dihydro- 3H-pyrazol-3-one were synthesized. Synthesized compounds were characterized on the basis of physicochemical as well as spectral data (UV, IR, 1HNMR and mass spectra) and evaluated for in vitro anti-microbial, anti-tubercular and cytotoxic activity. All the synthesized compounds (100 Âµg/disc) showed mild to moderate activity against Gram-positive bacteria, more potent or equal activity against Gram-negative bacteria and moderate to significant anti-fungal activity compared w

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Shahid, M., Anwar Shahzad, Abida Malik, and M. Anis. "Antibacterial activity of aerial parts as well as in vitro raised calli of the medicinal plant Saraca asoca (Roxb.) de Wilde." Canadian Journal of Microbiology 53, no. 1 (2007): 75–81. http://dx.doi.org/10.1139/w06-107.

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Leaves, stem, and flowers of Saraca asoca, an endangered medicinal plant in India, and young explants cultivated on Murashige & Skoog's medium containing 6-benzylaminopurine were analyzed for antibacterial potential. Alcoholic and aqueous extracts from parent explants and their in vitro raised calli were tested by an agar well diffusion method. Minimal inhibitory concentrations (MICs) of the extracts were determined by broth microdilution method. Aqueous extracts showed antibacterial activity against limited bacterial species, whereas alcoholic extracts were active against a wider range of

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Visweswara, Rao Ch, Banoth Reddy, K. Nagapurnima, Rao K. Appa, and Shaik Lakshman. "Synthesis and bioevluation of BIS (Indolyl) methane derivatives using copper halide catalyst." Research Journal of Chemistry and Environment 26, no. 2 (2022): 89–100. http://dx.doi.org/10.25303/2602rjce89100.

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A mild and an efficient method catalyzed by copper iodide in TMEDA as solvent was used for the synthesis of bis(indolyl) methanes through a cascade process between indole and substituted aromatic aldehyde to produce the corresponding bis (indolyl) alkanes in moderate to good yields under reflux conditions. All structures of the desired products were evaluated using spectroscopic techniques 1H NMR, 13C NMR spectroscopy and LCMS. The structure of the compounds was determined by elemental analysis. The antibacterial activity of newly synthesized compounds was investigated against gram positive ba

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González-Alamilla, Eddy Nathalye, Manases Gonzalez-Cortazar, Benjamín Valladares-Carranza, et al. "Chemical Constituents of Salix babylonica L. and Their Antibacterial Activity Against Gram-Positive and Gram-Negative Animal Bacteria." Molecules 24, no. 16 (2019): 2992. http://dx.doi.org/10.3390/molecules24162992.

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The principle of animal wellbeing, which states that animals should be free from pain, injury, and disease, is difficult to maintain, because microorganisms are most frequently found to be resistant or multi-resistant to drugs. The secondary metabolites of plants are an alternative for the treatment of these microorganisms. The aim of this work was to determine the antibacterial effect of Salix babylonica L. hydroalcoholic extract (SBHE) against Escherichia coli, Staphylococcus aureus and Listeria monocytogenes, and identify the compounds associated with the activity. The SBHE showed activity

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Arisoy, Mustafa, Ozlem Temiz-Arpaci, Fatma Kaynak-Onurdag, and Selda Ozgen. "Novel Benzoxazoles: Synthesis and Antibacterial, Antifungal, and Antitubercular Activity against Antibiotic-Resistant and -Sensitive Microbes." Zeitschrift für Naturforschung C 68, no. 11-12 (2013): 453–60. http://dx.doi.org/10.1515/znc-2013-11-1204.

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A new series of 5-(p-substituted benzamido/phenylacetamido)-2-(p-tert-butylphenyl)benzoxazole derivatives were synthesized and evaluated for their antibacterial, antifungal, and antimycobacterial activities against antibiotic-resistant and -sensitive Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and Mycobacterium tuberculosis as well as against Candida albicans and Candida krusei. The compounds possessed broad-spectrum activity against all of the tested Gram-positive and Gram-negative bacteria and yeasts, their minimum inhibitory concentrations (MICs) r

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Wakodkar, Rohit R., Mazahar Farooqui, Pravin Kulkarni, and Deepak D. Kayande. "Synthesis and Biological Activity of Some Thiosemicarbazide." Asian Journal of Organic & Medicinal Chemistry 4, no. 4 (2019): 228–31. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p206.

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In this paper, thiosemicarbazone derivatives have been prepared from substituted aromatic aldehyde and thiosemicarbazide in presence of sodium chloride. This method is an efficient, mild, inexpensive, non-toxic and environment benign catalyst. This protocol includes the reaction followed by using sodium chloride to accelerate the reaction in aqueous ethanol. The structure of synthesized compounds were determined by IR, 1H NMR, 13C NMR and mass spectroscopies as well as the compounds were also screened for antibacterial and antifungal activity against certain Gram-negative and Gram-positive bac

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BHARDWAJ, GAUTAM, SURESH KUMAR, and RAJIV KUMAR TONK. "Anticancer and Antimicrobial Screening of Novel Pyrazolo[2,3-c]pyridopyridazine Analogues: Synthesis, Spectral Characterization, Molecular Docking and Dynamics Studies." Asian Journal of Chemistry 35, no. 11 (2023): 2837–44. http://dx.doi.org/10.14233/ajchem.2023.30477.

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A major threat in cancer management is the development of drug resistance and gene mutations. Serine threonine kinases like DYRK1A pathway are potential targets for cancer therapies. In this work, a new series of seven pyrazolo[2,3-c]pyridopyridazine analogs were synthesized and characterized by spectroscopic methods. Three compounds were evaluated for in-vitro anticancer activity following 60 cell lines protocol of NCI, USA and for antimicrobial activity against Gram-negative and Gram-positive bacteria. All the compounds exhibited moderate to good antibacterial activity, while compounds 4a, 4

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Stana, Anca, Brînduşa Tiperciuc, Mihaela Duma, Adrian Pîrnău, Philippe Verité, and Ovidiu Oniga. "Synthesis and antimicrobial activity of some new N-(aryl-oxo-alkyl)-5-arylidene-thiazolidine-2,4-diones." Journal of the Serbian Chemical Society 79, no. 2 (2014): 115–23. http://dx.doi.org/10.2298/jsc130114078s.

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A series of new 5-(2,6-dichlorobenzylidene)thiazolidine-2,4-dione and 5-(4-methoxy-benzylidene)thiazolidine-2,4-dione derivatives (3a-h and 5a-h) were synthesized starting from 5-arylidene-thiazolidine-2,4-dione and ?-halo-ketones. The structural elucidation of the newly synthesized compounds was based on elemental analysis and spectroscopic data (MS, 1H-NMR, 13C-NMR). The synthesized compounds were screened for their antimicrobial activities against several pathogenic strains of Gram-positive and Gram-negative bacteria and one fungal strain (Candida albicans), assessed in vitro as growth inhi

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Hassan, Huda Salman, and Sana Hitur Awad. "SYNTHESIS AND CHARACTERIZATION OF NEW SCHIFF BASES FOR CHITOSAN AND STUDY THEIR ANTIMICROBIAL ACTIVITY." Iraqi Journal of Market Research and Consumer Protection 15, no. 2 (2023): 192–206. http://dx.doi.org/10.28936/jmracpc15.2.2023.(19).

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Biopolymers and their derivatives have a wide range applications due to their biodegradability, low toxicity, and biocompatibility. The current study aimed to develop and characterize the unique Schiff ,s chitosan bases by conjugation the chitosan with different aldehydes under acidic conditions to form Schiff ,s chitosan bases which reacted with a plant extract derivative (capsaicin) to get new Schiff ,s derivatives. The resulting compounds were diagnosed by using fourier transform infrared (FT-IR), as well as nuclear magnetic resonance(1H-NMR). The biological activity of the new derivatives

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Doshi, Viralkumar Arvindbhai, and Yogesh S. Patel. "Novel Benzimidazole based Hydrazide-hydrazone Compounds: Synthesis, Characterization and Antimicrobial Assessment." Asian Journal of Chemistry 36, no. 8 (2024): 1793–802. http://dx.doi.org/10.14233/ajchem.2024.31484.

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This work presents a comprehensive study on the design, synthesis, spectral characterization and antimicrobial assessment of new hydrazide-hydrazone incorporated benzimidazole compounds (6a-p). The synthesis of these compounds (6a-p) involved the condensation of benzimidazole derivative, 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butane hydrazide with substituted aromatic aldehydes, utilizing an efficient and environmentally benign synthetic route. The IR, NMR and mass spectrometry were among the spectroscopic methods used to characterize the novel synthesized substances to confirm their che

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Kavitha, .S, B. Baijika., Mathew Cyril, K. P. Jithamol, and Purandharan Aswani. "A Review of Coumarin as Antibacterial Agent." Journal of Advances in Pharmaceutical Sciences 1, no. 2 (2023): 32–44. https://doi.org/10.5281/zenodo.10089048.

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<i>Coumarin is the heterocyclic compound formed from benzene and pyrone ring containing oxygen atom. Coumarin derivatives have different biological activities such as anticancer, antimicrobial, antimalarial, antioxidant, antiviral, anti-inflammatory analgesic, antianxiety etc. The synthesised coumarin derivatives were screened for their anti-bacterial activity by means of Disc-well diffusion assay against Gram-positive bacteria and Gram-negative strains. The compounds proved that it is moderate to significant anti-bacterial activity. This review is based on the synthesis of various coumar

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Kačániová, Miroslava, Petra Borotová, Lucia Galovičová, et al. "Antimicrobial and Antioxidant Activity of Different Honey Samples from Beekeepers and Commercial Producers." Antibiotics 11, no. 9 (2022): 1163. http://dx.doi.org/10.3390/antibiotics11091163.

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Honey contains compounds with antioxidant and antibacterial capacities, such as phenolic compounds and carotenoids. The current analysis evaluates the antioxidant and antibacterial activity of 100 honey samples from beekeepers from Slovakia and commercially purchased ones. Honey samples were diluted to 50%, 25%, 12.5%, and 6.25% concentrations. The antimicrobial activity of honey samples was evaluated against three Gram-positive, three Gram-negative bacteria, and four Candida spp. by well diffusion method. The highest antimicrobial effect of all honey concentrations was expressed as the size o

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SHARAVANAN, S. P. N., C. S. VENKATESAN, D. BHASKARA SURESH RAJU, and S. KABILAN. "Synthesis, Characterization and Biological Evaluation of Some Novel Regioisomers of Ropivacaine Analogues: An Anaesthetic Drug." Asian Journal of Chemistry 32, no. 9 (2020): 2180–86. http://dx.doi.org/10.14233/ajchem.2020.22722.

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A series of ropivacaine analogues were synthesized by altering the methyl group substituent in the aromatic ring. The synthesized compounds (2a-f and 3a-f) were characterized by using IR, NMR and HRMS analysis and then compounds 3a-3f were screened in vitro anticancer (MTT assay) activity against breast cancer cell line (MCF-7), antibacterial and antioxidant (DPPH scavenging assay) studies. The biological studies revealed that the compounds 3c and 3f have shown a good inhibitory activity against MCF-7 cell line. Compounds 3e, 3b, 3c and 3f showed moderate antioxidant activity. There was no inh

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Sima, Sikdar, Roy Surajit, Nazira Banu Tarique, Alam Mondal Mohabul, and Mandal Shyamapada. "Phytochmical analysis and antibacterial property assessment of helencha (Enhydra fluctuans; Family: Asteraceae) extracts." GSC Biological and Pharmaceutical Sciences 12, no. 2 (2020): 136–42. https://doi.org/10.5281/zenodo.4268135.

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This communication stands for the phytochemical analysis, and antibacterial activity of <em>Enhydra fluctuans</em>, alone and in combination with some antibiotics, against gram-negative and gram-positive bacteria. Following disc diffusion, the methanolic extract of <em>E. fluctuans</em> (MEE) had antibacterial activity against gram-positive (<em>B. cereus </em>and <em>L. monocytogenes</em>) and gram-negative (<em>A. baumannii</em> and <em>P. aeruginosa</em>) clinical as well as standard (<em>E. coli </em>ATCC 25922 and <em>L. monocytogenes </em

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Zuhaira, S., Noorhaniz Mohd Nizam, and PM Ridzuan. "The Efficacy of Psidium guajava Linn Leaf Extractsfrom Selangor Region Against Gram-Positive and Gram-Negative Bacteria." Folia Medica Indonesiana 54, no. 4 (2018): 294. http://dx.doi.org/10.20473/fmi.v54i4.10716.

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Antibiotic is a type of medication that helps in fighting bacterial infection. Treating bacterial infections in clinical setting become more complicated and costly due to drug resistance. This study was conducted to determine the antibacterial potential of Psidium guajava Linn leaf extracts against Gram-positive and Gram-negative bacteria. P. guajava Linn leaf was obtained from Research Orchards at University Putra Malaysia (UPM). Leaves were extracted using three types of extracts; hot, cold and methanol extract. Freeze dried was used in this study and temperature was set at -104°C for 24 hou

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Cetin, Adnan, and Havva Kurt. "Synthesis, Antibacterial Activity and Molecular Docking Studies of New Pyrazole Derivatives." Letters in Drug Design & Discovery 17, no. 6 (2020): 745–56. http://dx.doi.org/10.2174/1570180816666190905155510.

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Background: The pyrazole structure is an important heterocyclic structure and plays critical roles in agriculture, industrial and medicine. Furthermore, compounds containing pyrazole are known to exhibit various biological properties such as antibacterial, antifungal, anticancer, antiinflammatory, antidepressant, antipyretic, antiviral, anti-tubercular and anti-HIV activities. Because of these properties, pyrazole molecules have become a very popular topic for organic chemists. Methods: A series newly substituted pyrazole molecules were synthesized and characterized. Their antimicrobial activi

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Roy, Debendra Nath, A. K. Azad, Farzana Sultana, and A. S. M. Anisuzzaman. "In-vitro antimicrobial activity of ethyl acetate extract of two common edible mushrooms." Journal of Phytopharmacology 5, no. 2 (2016): 79–82. http://dx.doi.org/10.31254/phyto.2016.5207.

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Ethyl acetate extracts of the reishi (Ganoderma lucidum) and oyster (Pleurotus ostreatus) mushrooms were tested for their in vitro growth inhibitory activity against a panel of microorganisms of reference strains. Antimicrobial effects of both mushrooms were monitored in the dose of 400 micro gm /disc by disc diffusion method using five Gram-positive bacteria, five Gram-negative bacteria and three fungi as well. Present study showed that ethyl acetate extract of Pleurotus ostreatus has moderate and Ganoderma lucidum has only mild antibacterial effect in comparison with standard Kanamycin (30 

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Sanghvi, Heli, and Satyendra Mishra. "Structure-Activity Relationship and Antimicrobial Evaluation of N-Phenylpyrazole Curcumin Derivatives." Current Bioactive Compounds 16, no. 4 (2020): 481–88. http://dx.doi.org/10.2174/1573407215666190124115010.

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Background: Curcumin, one of the most important pharmacologically significant natural products, has gained significant consideration among scientists for decades since its multipharmacological activities. 1, 3-Dicarbonyl moiety of curcumin was found to be accountable for the rapid degradation of curcumin molecule. The aim of present work is to replace 1, 3-dicarbonyl moiety of curcumin by pyrazole and phenylpyrazole derivatives with a view to improving its stability and to investigate the role of substitution in N-phenylpyrazole curcumin on its antibacterial activity against both Gram-positive

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43

Boovaragamurthy Ahilan, Pachaiyappan Saravana Kumar, Veeramuthu Duraipandiyan, Melvin A Daniel, and Savarimuthu Ignacimuthu. "Antibacterial efficacy of some Indian medicinal plants against human commensal pathogens." International Journal of Fundamental and Applied Sciences (IJFAS) 6, no. 3 (2017): 10–15. http://dx.doi.org/10.59415/ijfas.v6i3.109.

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Background and Aim: The present study aimed to evaluate the antibacterial efficacy of the total flower extracts offive medicinal plants widely used in folk medicine in India, against some Gram positive and Gram negative bacteria.Methodology: The present work designed to assess the in vitro antibacterial activities of five medicinal plants(flowers of Bauhinia purpurea, Clitoria ternatea, Millingtonia hortensis, Nyctanthes arbortristis and Combretumindicum) against panel of Gram positive bacteria and Gram negative bacteria using disk diffusion assays. Results:Among the plants screened, Combretum

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Menezes, Vinícius Paulino Pinto, Aldeni Moreira da Silva Filho, Aline Jeferson Costa, et al. "Bioprospecting of Marine Organisms: Exploring Antibacterial Activities in Aqueous and Organic Extracts." Microorganisms 13, no. 4 (2025): 940. https://doi.org/10.3390/microorganisms13040940.

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This study evaluated the antibacterial activity of aqueous and organic extracts from 78 marine organisms, including seaweeds and sponges, collected along the coast of Ceará, Brazil. Extracts were obtained by maceration using distilled water and 50% acetonitrile and tested against Staphylococcus aureus, Staphylococcus epidermidis (Gram-positive), and Escherichia coli (Gram-negative) using the disk diffusion method, and inhibition zone diameters were measured. Antibacterial activity was observed in 30.7% of the extracts, with organic extracts showing higher efficacy. Several sponge species, part

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NAIDU, Gandi Kishore, B. SUJATHA, and K. Chandra Sekhar NAIDU. "In vitro Antibacterial Activity Analysis of Leaves of Limonia acidissima." Notulae Scientia Biologicae 6, no. 2 (2014): 155–57. http://dx.doi.org/10.15835/nsb629270.

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The present study was carried out the antibacterial activity and phytochemical screening of the hexane, chloroform and methanol extracts of leaves of Limonia acidissima. The antibacterial activity was evaluated against four Gram-negative (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris) and five Gram-positive bacteria (Bacillus subtilis, Enterococcus faecalis, Micrococcus luteus, Staphylococcus aureus, Streptococcus pneumoniae) by agar well diffusion method. Methanol extract showed good antibacterial activity with the high inhibition zones while chloroform ext

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Mandal, Sudip Kumar. "INDANYL ANALOGS AS POTENTIAL ANTIMICROBIAL AGENTS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 278. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.24635.

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Objective: The wide variety of biological activities of different indane derivatives makes them an interesting moiety in the field of medicinal chemistry. The objective of the study was to identify and develop novel antimicrobial agents from indanyl analogs.Methods: Recently synthesized indanyl analogs (4a-c and 5a-o) were examined against various pathogenic microorganisms (Gram-positive and Gram-negative bacteria and fungi) using serial dilution method. These analogs were found to possess antibacterial and antifungal activities with minimum inhibitory concentration values ranging between 1.56

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Rahmawatiani, Ayu, Dewi Mayasari, and Angga Cipta Narsa. "Kajian Literatur: Aktivitas Antibakteri Ekstrak Herba Suruhan (Peperomia pellucida L.)." Proceeding of Mulawarman Pharmaceuticals Conferences 12 (December 16, 2020): 117–24. http://dx.doi.org/10.25026/mpc.v12i1.401.

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Suruhan (Peperomia Pellucida L.) is one of the weed plants that grow wild in humid environments. This plant is commonly found in Indonesia and has been used by the community as a medicinal plant. The secondary metabolites contained oh suruhan are saponins, phenols, flavonoids, and tannins. These compounds are thought to provide antibacterial activity. The purpose of writing this literature review is to determine the compound of secondary metabolites, the antibacterial activity of the extract, and the effective concentration as an antibacterial agent. The method used is literature review by sea

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Gupta, Monika. "Synthesis, Spectral Studies and Antimicrobial Activity of Coumarin Derivatives." International Journal of Pharmacognosy & Chinese Medicine 5, no. 2 (2021): 1–8. http://dx.doi.org/10.23880/ipcm-16000222.

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An antimicrobial is a substance that kills or inhibits the growth of microorganisms such as bacteria, fungi, or protozoans. Microorganisms have existed on the earth for more than 3.8 billion years and exhibited the greatest genetic and metabolic diversities. They are an essential component of the biosphere and serve an important role in the maintenance and sustainability of ecosystems. Heterocyclic compounds are cyclic compounds with the ring containing one or more atom other than carbon. The fusion of pyrone ring with benzene nucleus give rise to a class of heterocyclic compound known as benz

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Gaurav Patel, Dr. Rizwan Gumrah, Dr. Tarun M Patel, and Khushbu Agrawal. "Exploring Novel Pyrazole-Fused 1H-tetrazol-5-yl: Synthesis, SAR and Antimicrobial Efficacy." Bioscan 19, Supplement 2 (2024): 323–32. http://dx.doi.org/10.63001/tbs.2024.v19.i02.s2.pp323-332.

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In this study, we present the synthesis, and biological activity of pyrazole-linked tetrazole derivatives (6A-6Q). All derivatives were screened for their antimicrobial activity against both gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, Bacillus megaterium) and gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Shigella spp.). The compounds were synthesized through a five-step reaction process and further characterized using 1H NMR and LCMS spectral techniques. The synthetic compounds 6A–6Q were evaluated for their experimental antimicrobial activity, with am

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Yin, Ying, Dongyang Wang, Dan Wu, et al. "Two New 4-Hydroxy-2-pyridone Alkaloids with Antimicrobial and Cytotoxic Activities from Arthrinium sp. GZWMJZ-606 Endophytic with Houttuynia cordata Thunb." Molecules 28, no. 5 (2023): 2192. http://dx.doi.org/10.3390/molecules28052192.

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Two new 4-hydroxy-2-pyridone alkaloids furanpydone A and B (1 and 2), along with two known compounds N-hydroxyapiosporamide (3) and apiosporamide (4) were isolated from the endophytic fungus Arthrinium sp. GZWMJZ-606 in Houttuynia cordata Thunb. Furanpydone A and B had unusual 5-(7-oxabicyclo[2.2.1]heptane)-4-hydroxy-2-pyridone skeleton. Their structures including absolute configurations were determined on the basis of spectroscopic analysis, as well as the X-ray diffraction experiment. Compound 1 showed inhibitory activity against ten cancer cell lines (MKN-45, HCT116, K562, A549, DU145, SF12

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