Journal articles: 'They were found in 25.6% in main group 1'

1

Lobzin, Sergey V., Grigoriy I. Shvartsman, Evgenia M. Pervova, Inga V. Chistova, and Ekaterina A. Yurkina. "Effect of vitamin D3 (cholecalciferol) levels on the development of cognitive and psychoemotional disorders in patients with cerebrovascular disease." Medical academic journal 20, no. 1 (2020): 93–100. http://dx.doi.org/10.17816/maj19225.

Full text

Abstract:

In recent years, the problem of vascular cognitive impairment is becoming increasingly important due to the increasing prevalence of cerebrovascular disease. The aim of this study was to determine the relationship between 25(OH)D, highly sensitive CRP, interleukin-1, interleukin-6 and cognitive function in patients with cerebrovascular disease and to assess their impact on quality of life. Materials and methods. 58 patients with cerebrovascular disease aged 3181 years were examined. The comparison group consisted of 24 patients, comparable in age and sex, without the studied pathology. In the study, patients were determined by the level of 25(OH)D, interleukin-1, interleukin-6, highly sensitive CRP in peripheral blood. All patients underwent neuropsychological, psychometric examination and study of their quality of life. Results. In the study, the level of 25(OH)D in patients with cerebrovascular disease was lower compared to the group without this pathology. Concentrations of interleukin-1, interleukin-6, and highly sensitive CRP in patients in the main group were statistically significantly higher than in those in the comparison group. Higher concentrations of highly sensitive CRP, interleukin-1, and interleukin-6 were found in patients with low vitamin D availability. The study obtained direct correlations between the level of 25(OH)D in peripheral blood and the results of neuropsychological testing (MMSE, MoCA, FAB, Schulte tables (performance), the Drawing hours test) and the inverse with the degree of workability (Schulte tables). An inverse correlation of average strength was observed between the results of psychometric testing and the level of 25(OH)D in peripheral blood. The study confirmed the relationship between the level of 25(OH)D in peripheral blood and quality of life indicators, in the form of a direct correlation. Conclusion. The study found that the higher the concentration of 25 (OH)D and the lower the level of interleukin-1, interleukin-6, and highly sensitive CRP in the peripheral blood, the less likely it is to develop cognitive and psychoemotional disorders. The study confirmed the relationship between the level of 25(OH)D and quality of life indicators.

APA, Harvard, Vancouver, ISO, and other styles

2

Tatarchuk, T. F., L. V. Kalugina, T. I. Kvasha, and R. O. Mnevets. "Vitamin D supplementation in bacterial vaginosis." REPRODUCTIVE ENDOCRINOLOGY, no. 68 (June 30, 2023): 36–42. http://dx.doi.org/10.18370/2309-4117.2023.68.36-42.

Full text

Abstract:

Research objectives: to evaluate the effect of vitamin D supplementation (Olidetrim) in the complex anti-relapse therapy of bacterial vaginosis (BV) in women of reproductive age.Materials and methods. The study included 63 women of reproductive age with BV and with a level of 25-hydroxyvitamin D below 75 nmol/l, who were divided into groups: the main group included 32 women who were prescribed standard therapy (metronidazole 500 mg twice a day for 7 days) and cholecalciferol (Olidetrim) 4000 IU/day with subsequent continuation of its intake in a dose 2000 IU/day for up to 6 months; the comparison group included 31 women, who were not intake vitamin D preparation during the standard therapy and during the next 6 months of observation.After treatment, women provided completed questionnaires and self-collected vaginal swabs 1, 3, and 6 months after beginning of the study or before BV relapse. Evaluation of Gram-stained smears was carried out by microscopy according to Hay/Ison criteria, where BV corresponded to type III. The level of 25-hydroxyvitamin D in blood serum was determined by the chemiluminescent immunoassay method before the start of thestudy and at 3 and 6 months of follow-up.The primary endpoint was BV recurrence at any post-treatment interval; the patients were offered a second treatment in this case.Results. Vitamin D deficiency at the beginning of the study was detected in 12 (37.5%) patients of the main group and in 13 (41.94%) women of the comparison group, an insufficient level – in 20 (62.5%) patients of the main group and in 58.06% women of the comparison group.Patients complained of pathological vaginal discharge, itching, burning and dyspareunia lasting from 1 week to 2 months. At the seven-day course of basic BV therapy all participants noted the normalization of discharge and the absence of vaginal discomfort. Positive dynamics were also observed according to the gynecological examination.One month after the treatment, 4 (12.5%) participants of the main and 6 (19.36%) women of the comparison group noted the recovery of symptoms. Absence of BV recurrence after 3 months was noted by 25 (78.12%) women of the main group and 16 (51.61%) women of the comparison group (p = 0.054), that was confirmed by the laboratory tests. At the same time, the level of 25-hydroxyvitamin D in the main group increased by 43.37% (p = 0.05), and in the comparison group it did not differ from the initial level. There were no complaints in 24 (75.0%) patients after 6 months, however, a laboratory-confirmed normal state of the vaginal microbiome was observed in 22 (70.96%) participants of the main group and in 14 (45.16%, p = 0.07) women of the comparison group. Continuation of vitamin D intake at a dose of 2000 IU/day for the next 3 months demonstrated maintenance of the 25-hydroxyvitamin D level within normal values (81.7 ± 6.23 nmol/l in the main group vs. 38.51 ± 5.43 nmol/l in comparison group, p = 0.05).Conclusions. A decrease in the frequency of BV recurrences in women during support a normal level of vitamin D was found, which allows recommending the inclusion of cholecalciferol supplementation (Olidetrim) in the standard treatment. In patients with recurrent BV a long-term monitoring of the serum level of vitamin D is advisable in order to timely prescribe supplementation.

APA, Harvard, Vancouver, ISO, and other styles

3

Croteau, Karen A., Vijiayurani Suresh, and Elanna Farnham. "Efficacy of Using Physical Activity Mentors to Increase the Daily Steps of Older Adults in the Primary Care Setting: A Pilot Study." Journal of Aging and Physical Activity 22, no. 1 (2014): 16–24. http://dx.doi.org/10.1123/japa.2012-0120.

Full text

Abstract:

The purpose of this pilot study was to determine if using physical activity (PA) mentors has any additional impact on daily steps of older adults participating in the Maine in Motion (MIM) program in the primary care setting. Participants were randomly assigned to a MIM-only group (n= 14) or a MIM+ mentor group (n= 14). The MIM intervention lasted 6 months with follow-up at 12 months. Average age of participants was 64 ± 8.8 years and most participants had multiple chronic illnesses. At baseline, mean body mass index (BMI) was 32.2 ± 5.1 and average daily steps were 4,236 ± 2,266. Repeated-measures ANOVA revealed significant main effects for steps,F(2.324, 59.104) = 4.168,p= .015, but no main effects for group,F(1, 25) = 2.988,p= .096, or time-by-group interaction,F(2.324, 59.104) = 0.905,p= .151. All participants significantly increased daily steps over the course of the intervention, with MIM+ participants maintaining increases at follow-up. No significant findings were found for BMI.

APA, Harvard, Vancouver, ISO, and other styles

4

Yusupov, A. F., S. S. Faizulloev, K. S. Khusanbaev, D. S. Bobozhonov, and M. S. Razhabova. "A clinical case of surgical correction of post-traumatic aphakia." Modern technologies in ophtalmology, no. 1 (March 25, 2022): 160–63. http://dx.doi.org/10.25276/2312-4911-2022-1-160-163.

Full text

Abstract:

Purpose. To optimize the technology of surgical treatment of rhegmatogenous retinal detachment by a combination of vitrectomy of the base of the vitreous body in air with 360° peripheral endolaser retinopexy and to evaluate its clinical and functional effectiveness. Material and methods. The control group included 25 patients (25 eyes) with peripheral vitrectomy under the fluid (BSS) with laser restriction of the retinal tear only. The study group included 25 patients (25 eyes) with peripheral vitrectomy under air in combination with 360° laser retinopexy. Groups were compared in terms of visual acuity, duration of retinal detachment, presence of proliferative vitreoretinopathy, macular condition, number of retinal tears, lens condition (phakic/pseudophakic), and recurrent retinal detachment. The frequency of intraoperative iatrogenic retinal tears that occurred during peripheral vitrectomy was also assessed. Results. In the main group, in one case, an atorogenic rupture was detected during surgery. In the control group, there were 3 cases of touching the periphery of the retina with the appearance of a rupture during vitrectomy in the “shave” mode. There are no statistically significant differences in visual acuity after 3-6 months. During the observation period, no retinal detachment recurrence was detected in the main group in any case. Whereas in the control group there were 2 relapses. Conclusions. The advantage of air vitrectomy is a greater view of the periphery of the retina during surgery, which in many cases does not require additional sclerocompression for better visualization. Also residual vitreous body between tissue-air environments is very well identified. 360° endolaser coagulation is a prophylactic procedure to prevent recurrence of retinal detachment. In addition, in our study, we found that peripheral air vitrectomy combined with 360° laser retinopexy had comparable results to fluid vitrectomy in shave mode, with laser limited only around tears. Keywords: rhegmatogenous retinal detachment, vitrectomy, endolaser coagulation

APA, Harvard, Vancouver, ISO, and other styles

5

Yusupov, A. F., S. S. Faizulloev, K. S. Khusanbaev, D. S. Bobozhonov, and M. S. Razhabova. "A clinical case of surgical correction of post-traumatic aphakia." Modern technologies in ophtalmology, no. 1 (March 25, 2022): 160–63. http://dx.doi.org/10.25276/2312-4911-2022-1-160-163.

Full text

Abstract:

Purpose. To optimize the technology of surgical treatment of rhegmatogenous retinal detachment by a combination of vitrectomy of the base of the vitreous body in air with 360° peripheral endolaser retinopexy and to evaluate its clinical and functional effectiveness. Material and methods. The control group included 25 patients (25 eyes) with peripheral vitrectomy under the fluid (BSS) with laser restriction of the retinal tear only. The study group included 25 patients (25 eyes) with peripheral vitrectomy under air in combination with 360° laser retinopexy. Groups were compared in terms of visual acuity, duration of retinal detachment, presence of proliferative vitreoretinopathy, macular condition, number of retinal tears, lens condition (phakic/pseudophakic), and recurrent retinal detachment. The frequency of intraoperative iatrogenic retinal tears that occurred during peripheral vitrectomy was also assessed. Results. In the main group, in one case, an atorogenic rupture was detected during surgery. In the control group, there were 3 cases of touching the periphery of the retina with the appearance of a rupture during vitrectomy in the “shave” mode. There are no statistically significant differences in visual acuity after 3-6 months. During the observation period, no retinal detachment recurrence was detected in the main group in any case. Whereas in the control group there were 2 relapses. Conclusions. The advantage of air vitrectomy is a greater view of the periphery of the retina during surgery, which in many cases does not require additional sclerocompression for better visualization. Also residual vitreous body between tissue-air environments is very well identified. 360° endolaser coagulation is a prophylactic procedure to prevent recurrence of retinal detachment. In addition, in our study, we found that peripheral air vitrectomy combined with 360° laser retinopexy had comparable results to fluid vitrectomy in shave mode, with laser limited only around tears. Keywords: rhegmatogenous retinal detachment, vitrectomy, endolaser coagulation

APA, Harvard, Vancouver, ISO, and other styles

6

Giro, T. M., A. V. Molchanov, A. N. Kozin, A. V. Giro, E. V. Fat’yanov, and V. V. Svetlov. "Use of iodine and selenium enriched fodder rations for production of fortified young lamb." Theory and practice of meat processing 6, no. 1 (2021): 46–55. http://dx.doi.org/10.21323/2414-438x-2021-6-1-46-55.

Full text

Abstract:

The article is devoted to preventive measures to eliminate the problem of dysmicroelementosis in order to increase the productivity of young sheep. The article presents the results of studies of the influence of feeding rations on the growth and development of young sheep of the Edilbaev breed, on the level of their meat productivity and the qualitative characteristics of biologically fortified lamb. Feed additives based on Yoddar-Zn and DAFS-25 were added to the main ration of lambs at the age of four months, once a day, being added into a fodder mixture with concentrates. For the experiment the herd of lambs was divided to four groups of 25 heads each.The changes in live weight at the age of four, five, six and seven months were analyzed, and it was found that at the age of seven months, the absolute average weight gain in the experimental groups varied from 3.45 kg to 4.49 kg, in the control group it was 3.1 kg, while the largest live weight gain was recorded in group III which received both feed additives based on Yoddar-Zn and DAFS-25.There were no significant differences in the parameters of body measurements, with the exception of group III, where the chest circumference increased by 7.2%, and the height of a lamb at the withers increased in average by 8.1%. It was found that group III had the highest meat density coefficient, equal to 3.9, and the cross-sectional area of m. Longissimus dorsi was equal to 13.61 cm2. It was noted that the amount of free amino acids of the lamb group III is 18.8% higher than the meat of the control group. The lamb obtained from the animals of the experimental groups showed a higher protein content and less fat. The ratio of water to protein in all samples was slightly higher than 3.7, which corresponds to the Federa number for meat raw materials. Enriching the rations of the Edilbaevskoy sheep with feed additives Yoddar-Zn and DAFS-25 promotes the stimulation of growth and development of animals, increases the productivity and nutritional value of lamb.

APA, Harvard, Vancouver, ISO, and other styles

7

Shahad, Ibrahim Jasim, and Saleh Khudhur Yossra. "Association between Colonization with Group B Streptococcus, Asymptomatic Bacteriuria and Preterm Labour." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES 03, no. 09 (2023): 2029–37. https://doi.org/10.5281/zenodo.8378847.

Full text

Abstract:

Background: For neonates that survive preterm labor, neurological illness still ranks as one of the main causes of perinatal mortality. Researchers have hypothesized that maternal recto-vaginal colonization with group B Streptococcus and asymptomatic bacteriuria during pregnancy might be risk factors for preterm birth. This study is to determine whether there is any connection between preterm birth, asymptomatic bacteriuria, and maternal group B streptococcus colonization.   Patients and Methods: From January 10 to September 6, 2020, Salah Al-Deen General Hospital's obstetrics and gynecology department conducted a clinical based case control research. In the research, group 1 consisted of (50) women who had preterm labor (24–36+6 weeks), whereas group 2 consisted of (50) women who had full-term pregnancies. A questionnaire, as well as a general and abdominal examination, were used to gather the data. By collecting a high vaginal swab and sending it for microbiological analysis, all patients were screened for genital colonization with Group B streptococcus. Urine cultures were used to check all patients for asymptomatic bacteriuria.   Results: Preterm births most frequently occurred in women between the ages of 25 and 29 (46%). The majority of women who gave birth prematurely came from rural regions, 30 (60%), were moms who worked at home, 42 (84%) and just 8 (16%) were employed. Positive urine cultures were detected in 10 (20%) more preterm births than in 3 (6% of full-term laboring mothers). A 30% detection rate of Group B Streptococcus was found in premature labor. 11 (22%) of preterm-born women had positive vaginal swaps for Group B Streptococcus, which is much more than the 4 (8% of full-term-born women).   Conclusions: E. coli made up the majority of the bacteria that were found, followed by Group B Streptococcus colonization. Women who had preterm deliveries had considerably more positive urine cultures for Group B Streptococcus than those who had full-term deliveries.

APA, Harvard, Vancouver, ISO, and other styles

8

Fabrian, Mihalcea Cristian. "Resistance of Pseudomonas Aeruginosa to Antibiotics in the Constanta Infectious Diseases Hospital During the SARS-COV2 Pandemic." ARS Medica Tomitana 28, no. 4 (2022): 154–57. http://dx.doi.org/10.2478/arsm-2022-0033.

Full text

Abstract:

Abstract Pseudomonas aeruginosa is a gram-negative, rod-shaped bacterium (bacillus), which can cause diseases in plants, animals, and humans. A species of considerable medical importance, Pseudomonas aeruginosa is a multi-antibiotic-resistant pathogen recognized for its ubiquity, its intrinsically advanced antibiotic resistance mechanisms, and its association with serious diseases: nosocomial infections (e.g.: ventilator-associated pneumonia) ⁠ or sepsis. Analysis of the resistance of the Pseudomonas bacillus to antibiotics during April 2020-September 2021 at the Constanta Clinical Hospital for Infectious Diseases. A retrospective study on a group of 36 patients infected with Pseudomonas aeruginosa aged between 6-70 years who were hospitalized between April 2020 and September 2021 in the Constanta Clinical Hospital for Infectious Diseases. We found that of the total number of patients infected with the Pioceanic bacillus, the majority were male (25-69.4%), and the rest were female (11-31.6%). Of the total number of patients, 2 were children aged 6 and 10, respectively. The main methods of germ isolation were: sputum-20 isolates, blood-1 isolates, auricular-2, throat-1, purulent secretion-2, secretion-3, tracheal aspirate-2, urine culture-5 isolates. Some 8 (22.2%) were from the ATI ward, from the adult ward some 19 (52.7%), and from the external HIV ward, some 6 (16.6%) and some 2 (5.5%) in the Pediatric ward. Regarding antibiotic resistance, we had resistance to the following antibiotics: Amikacin 9 (25%), Ciprofloxacin 9 (25%), Piperacillin-Tazobactam 16 (44.4%), Imipenem 13 (36%), Meropenem 12 (30.3%), Ceftriaxone 1 (2.7%), and sensitivity we found: Amikacin 14 (38.8%), Ciprofloxacin 23 (63.8%), Pipercilintazobactam 23 (63.8%), Meropenem 12 (30.3%), Imipenem 23 (63.8%), Ceftriaxone.

APA, Harvard, Vancouver, ISO, and other styles

9

Chanda, Dr Utpal Kumar, Dr Rowshan Ara Begum, Dr Manika Rani Kundu, Dr Debasish Kumar Gosh, Dr S. M. Khaliduzzaman, and Dr Jhorna Das. "The Association of Systemic Lupus Erythematosus with Autoimmune Hypothyroidism." Scholars Journal of Applied Medical Sciences 10, no. 12 (2022): 2402–5. http://dx.doi.org/10.36347/sjams.2022.v10i12.053.

Full text

Abstract:

Background: It's fairly uncommon for one autoimmune illness to coexist with another. Systemic lupus erythematosus (SLE) and underactive thyroid are two of the most frequent autoimmune disorders. They could have some kind of connection. Objective: In this study our main goal is to evaluate the association of Systemic Lupus Erythematosus with Autoimmune Hypothyroidism. Method: This cross sectional study was carried out tertiary hospital Bangladesh from June 2021 to June 2022. A total of 100 randomly selected indoor and outdoor SLE patients of both sexes and different age groups were enrolled for the study (Group-1). Total 100, age and sex matched healthy controls without SLE (Group-2) was selected for comparison. Verbal consent was taken from both group and ethical clearance was obtained from local ethical committee. Results: During the study, 21-25 years age group, 31% and 95% were female. In group-1 45% had hypothyroidism, followed by 35% had subclinical hypothyroidism, 35% had enlarged thyroid gland. Whereas in group-2 26% had hypothyroidism, followed by 55% had subclinical hypothyroidism. In Group-1 m hemolytic anemia 25%, ITP 21%, APS 20%, Type I DM 9%, MCTD 8%, RA 5%, Dermatomyositis- Polymyositis 6%, Grave’s Disease 4% and miscellaneous 2%. Whereas in case of Coexisting non-immunologic diseases cushingoid 30%, PUD 6%, CKD 6, dyslipidemia 21%, osteoporosis 5%, hepatitis 2%, IHD 4%, CVD 2%. Conclusion: There was no conclusive proof that SLE caused autoimmune hypothyroidism. The clinical presentation of these disorders is likewise similar. This means that all SLE patients may benefit from having a thyroid screening test performed to check for autoimmune hypothyroidism. It is important to look for any autoimmune disorders that may be present and treat any comorbidity found. All of these things are important to think about while choosing a treatment for SLE and improving its management.

APA, Harvard, Vancouver, ISO, and other styles

10

Zhou, Wei-Na, Yong-Chu Pan, Yan-Chi Tang, et al. "Comparative Outcomes of Block and Cancellous Iliac Bone Grafting in Older Unilateral Alveolar Cleft Patients." Cleft Palate-Craniofacial Journal 56, no. 7 (2019): 936–43. http://dx.doi.org/10.1177/1055665618822410.

Full text

Abstract:

Objective: To compare osseous outcomes of block and cancellous iliac bone grafting in older unilateral alveolar cleft patients. Design: Retrospective and observational follow-up study. Setting: Cleft Lip and Palate Centre, Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, China. Patients: Forty-five nonsyndromic patients with unilateral complete alveolar cleft were enrolled in this study (25 patients in block bone graft group and 20 patients in cancellous bone graft group). Interventions: In cancellous bone graft group, the alveolar cleft was filled with iliac cancellous bone particulate. In group of block bone graft, the harvested bone block was trimmed and fixed in alveolar defect. Main Outcome Measures: A novel method was proposed to investigate the volume and density of residual bone graft at 1-week, 3- and 6-month, 1- and 2-year postoperatively based on cone beam computed tomography scans. Results: No difference in bone graft volume was found between 2 groups at 1-week and 3-month postoperatively; however, the residual volume of block bone graft group was significantly larger than that of cancellous bone graft group at 6-month, 1- and 2-year postoperatively. The bone density of block bone graft group was lower at 1-week and 3-month postoperatively but was comparable at 6-month, 1- and 2-year postoperatively. Our method was reliable and accurate to identify the range of residual bone graft when the boundary of grafted bone could not be identified clearly. Conclusion: Block bone graft could achieve comparable bone density and retain a greater amount of residual bone comparing to cancellous bone graft.

APA, Harvard, Vancouver, ISO, and other styles

11

Rathod, Jawahar, Prajwaleet Gour, Subinay Saha, Shivprasad Jaybhay, and Rohit Verma. "Low-Dose Paclitaxel-Coated Balloon Angioplasty versus Uncoated Percutaneous Transluminal Balloon Angioplasty for Femoropopliteal Peripheral Artery Disease: 6-Month Results in a Tertiary Care Hospital of Central India." Journal of Clinical Interventional Radiology ISVIR 03, no. 02 (2019): 074–80. http://dx.doi.org/10.1055/s-0039-1693629.

Full text

Abstract:

Abstract Introduction Superficial femoral and popliteal arteries are the most common locations of peripheral vascular disease (PVD). Endovascular interventional therapy including drug-coated balloon (DEB) angioplasty or percutaneous transluminal angioplasty (PTA) and stenting are important options for treatment of PVD. Aims and Objectives The main objective is to compare the efficacy of DEB over PTA with optional stenting in management of obstructive femoropopliteal lesions in terms of 6-month patency rate. Materials and Methods The clinical experimental study was carried out in a tertiary care center over duration of 2 years. All symptomatic patients having lower limb PVD in femoropopliteal segment were included. Total 37 patients were included in this study in which 16 underwent plain balloon angioplasty (with 3 patients undergoing bare metal stenting [BMS]) and 21 additional underwent DEB angioplasty. Patients with previously intervened lesions, primary lesion failure, major ischemic tissue loss, poor aortoiliac or common femoral inflow, or end-stage kidney disorders were excluded. Result At 1-month follow-up, patency rates in DEB and conventional PTA ± BMS were 85.71% and 87.5%, respectively. On 6-month follow-up, patency rates were found to be 71.4% versus 37.5%, respectively (p = 0.039; significant). In case of occluded lesions, on 6-month follow-up, patency rate in DEB group was higher than that in plain balloon group (66.7% vs. 25%). In both the cohorts, success rate, i.e., patency rates were more in short and intermediate length lesions than long segment lesions. DEB was found to be superior to plain angioplasty with optional stenting in terms of 6-month patency rate.

APA, Harvard, Vancouver, ISO, and other styles

12

Horban, I. I., N. I. Mykyyevych, M. A. Pasichnyk, and N. V. Jarychkivska. "Study of Activity of the Carious Process in People of Different Ages Using the Index Assessment of DMF and ICDAS." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 7, no. 3 (2022): 212–16. http://dx.doi.org/10.26693/jmbs07.03.212.

Full text

Abstract:

The purpose of the work was to study the activity of the carious process in people of different ages using the assessment of the Decayed, Missing, and Filled Teeth and the International Caries Detection and Assessment System index. Materials and methods. The study involved 53 people who were divided into groups: group 1 – 16 people aged 18 to 25 years, group 2 – 20 people aged 26 to 35 years and group 3 – 17 people aged 36 to 45 years. The intensity of caries was determined using the Decayed, Missing, and Filled Teeth index. The International Caries Detection and Assessment System index was used to assess the activity of carious lesions. Results. The indicators of the Decayed, Missing, and Filled Teeth index in the group of people aged 18-25 years significantly differed (p <0.05) from the indicators in the group of people aged 26-45 years. In the group of people aged 36-45 years the indicators were higher than in the group of people aged 26-45 years, but no significant difference (p˃0.05) was found. In the group of people aged 18-25 years the share of filled teeth was 61.5%, teeth affected by caries were found in 29.4%, and removed teeth – in 9.1%. In the group of people aged 26-45 years, the rate of filled teeth was lower compared to people of the 1st group, the share of carious teeth increased up to 35.0%, and the number of removed teeth increased up to 16.4%. In the group of people aged 36-45 years the share of teeth affected by caries was lower than in the 1st and 2nd groups and was equal to 27.3%, the share of filled teeth was 46.2%, which is lower than in other groups, but the share of removed teeth was the highest of the groups which were examined and was 26.5%. The results indicate a rapid increase in the intensity of caries in patients of main working age, namely persons of the 2nd and 3rd groups compared with persons of young working age of the 1st group. The study of the depth of caries in enamel and dentin according to the International Caries Detection and Assessment System showed that in patients aged 18-25 years, from all teeth which are affected by caries in 71.4% enamel caries was found, which averaged 1.81 ± 0.2 teeth and in 28.6% – dentin lesions, which was an average of 0.68 ± 0.2. In patients aged 26-35 years, codes 1-3 accounted for 41.0% of affected teeth (mean 2.05 ± 0.1 teeth) and code 4-6 accounted for 59.0% of affected teeth (average 2.95 ± 0.2 teeth). In patients of the oldest age group, the number of teeth affected by caries with a code of 1-3 was 27.9% (average of 1.12 ± 0.1 teeth) and with a code of 4-6 was 72.1% (average of 2.88 ± 0.2 teeth). Conclusion. As the age of patients increases, the proportion of filled teeth decreases, but the proportion of removed teeth increases. The highest percentage of teeth affected by caries was found in the 3rd group. As the age of patients increases, both the average number of carious teeth and the number of teeth with damage dentin increase

APA, Harvard, Vancouver, ISO, and other styles

13

Romashchenko, Pavel N., Nikolay A. Maistrenko, and Denis S. Krivolapov. "PREVENTION OF YATROGENIC DAMAGES OF THE LARYNGEAL NERVES IN TRADITIONAL AND MINIMALLY INVASIVE THYROID SURGERY." Bulletin of the Russian Military Medical Academy 19, no. 1 (2017): 17–24. http://dx.doi.org/10.17816/brmma12160.

Full text

Abstract:

Objective. To assess the effectiveness of using the intraoperative neuromonitoring for conventional and minimally invasive surgical interventions on the thyroid gland for the prevention of the laryngeal nerve damage. Material and methods. For achieving this goal it was performed the retrospective analysis of surgical treatment of 310 patients with thyroid gland diseases, and 54 patients were selected, which were divided into 2 groups matched by sex and age, the nature of thyroid pathology and volume of surgical intervention: in the first (main, n = 27) operations were carried out using intraoperative neuromonitoring, in the second (control, n = 27) - visual monitoring of the laryngeal nerves was performed. The survey was performed according to the Russian and international clinical guidelines. Laryngoscopy was performed for all patients before operation and for patients with impaired phonation function - after it. «NIM-Neuro® 3.0» device with special armored endotracheal tubes preloaded with circular (detecting), as well as stimulating electrodes for searching and continuous monitoring of laryngeal nerves was used for intraoperative neuromonitoring during the operation. Results of the study. Traditional interventions were conducted on the 6 patients, minimally invasive nonendoscopic surgical - on 25, video-assisted - on 23. The exterior branch of the superior laryngeal nerve has found in 25 (92.6%) patients of the main group and 8 of the (29.6%) control group. Recurrent laryngeal nerve was identified in 27 (100%) patients of the 1st group and in 26 (96.3%) patients of the 2nd group by visual inspection. In the main group there are no cases of intraoperative fixation of the loss or signal attenuation during the laryngeal nerves monitoring, which is proved by the absence of single- and double-sided paresis of the larynx in the postoperative period. Only in 2 patients there was functional dysphonia on hypotonic type. In the control group the laryngeal dysfunction in the form of functional dysphonia (n = 1), paresis (n = 1) and paralysis (n = 1) has occurred in 3 patients. Conclusion. It has been found out that intraoperative neuromonitoring is an effective additional method of neural structures detecting, and it does not substitute the anatomic visualization of laryngeal nerves. intraoperative neuromonitoring in patients with high risk of complications (repeated operations on the thyroid gland, thyroid cancer with extrathyroidal proliferation and regional metastases) can reduce the incidence of paresis and paralysis of the larynx. All minimally invasive interventions on the thyroid gland should be accompanied by the intraoperative neuromonitoring of laryngeal nerves (8 figs, 1 table, bibliography: 15 refs).

APA, Harvard, Vancouver, ISO, and other styles

14

Nefihancoro, Udi Heru, Hartono Hartono, Dono Indarto, and Aryadi Kurniawan. "The effect of red yeast rice on delayed union fracture in animal model: a molecular study of IL-6, BMP-2, VEGF, BALP, and N-Mid-OC in fracture healing." F1000Research 11 (November 29, 2022): 1398. http://dx.doi.org/10.12688/f1000research.125859.1.

Full text

Abstract:

Background As serious fracture complications, delayed union and non-union are parts of complications from fracture healing. Growth factors such as BMP-2, VEGF, proinflammatory cytokines including IL-6 and bone formation BALP, N-Mid-OC are important regulators of the fracture healing process. Red yeast rice (RYR), produced by fermenting Monascus purpureus rice, monacolin K, which is the main ingredient in RYR, was found to play a major role in the anti-inflammatory process and increasing the proliferation of osteoblast in osteoporosis cases. This study aims to examine the effect of RYR in the fracture healing process in delayed union rats through molecular studies of levels of IL-6, BMP- 2, VEGF, BALP, and N-Mid-OC. Methods This study was experimental research that used male rats (Rattus novergicus) which were divided into a control and 3 treatment groups using a random sampling method. Group 1 was given orally 25 mg/kg, Group 2 was 50 mg/kg, Group 3 was 100 mg/kg, and the control group was given a placebo. The rats were then subjected to a delayed union fracture model. Observations were made for two periods on the 14th and 28th days. Results There were no significant differences in serology examination between days 0 and 14 between groups. However, there were significant differences between groups on day 28. IL-6, BMP-2, VEGF, BALP, and N-Mid-OC on day 28 between groups (p<0.001). The group with 100 mg/kg RYR extract was found to be the most influencing serology marker level. RYR 100 mg/kg significantly decreased IL-6, and increased BMP-2, VEGF, BALP, and N-Mid-Osteocalcin, thus enhancing the fracture healing process in the delayed union rats model. Conclusion A red yeast rice dose of 100 mg/KgBW significantly reduced IL-6, increased BMP-2, VEGF, BALP, N-Mid-OC, and RUST Score so as to improve the fracture healing process in delayed union rats.

APA, Harvard, Vancouver, ISO, and other styles

15

Kalinin, R. E., I. A. Suchkov, A. S. Pshennikov, and A. A. Nikiforov. "Pharmacological correction of endothelium functional state in patients with atherosclerotic peripheral artery occlusive disease." Kazan medical journal 94, no. 2 (2013): 181–85. http://dx.doi.org/10.17816/kmj1584.

Full text

Abstract:

Aim. To evaluate the effects of medications of different pharmacological groups on endothelial cells in patients with atherosclerotic peripheral artery occlusive disease. Methods. The study included 116 patients with atherosclerotic peripheral artery occlusive disease. Patients were divided into 4 groups depending on the taken drug (first group - 29 patients receiving L-arginine; second group - 30 patients, perindopril; third group - 28 patients, losartan; fourth group - 29 patients, nebivolol). Levels of the main biochemical markers reflecting the endothelium functional state were evaluated in all patients on admission to the hospital and 1, 3, and 6 months after the beginning of treatment. Results. All studied drugs stimulated nitric oxide (II) release (р 0.05). The highest increase of nitric oxide (II) level was found in patients receiving nebivolol and losartan. Levels of endothelin-1 tended to decrease in all patients. Superoxide dismutase level change was different both by number and trend in different groups; however, by the 6th month its level has lined up in all of the study groups. Lipid peroxidation parameters variation showed the same tendency as superoxide dismutase level variation. No significant changes in ankle-brachial index were found (р 0.05). Treadmill test showed a statistically significant improvement of pain-free walking distance by approximately 25-30% by the 3rd month of treatment (р 0.05). Conclusion. The studied medications influence endothelial cells and correct the endothelial cells functional state, reflected by change of all biochemical markers levels.

APA, Harvard, Vancouver, ISO, and other styles

16

Danilova, L. P., V. V. Egorov, G. P. Smoliakova, et al. "Effectiveness of combined therapy of neovascular age-related macular degeneration using anti-VEGF drug aflibercept and nutraceutical «Resvega Forte»." Modern technologies in ophtalmology, no. 1 (May 29, 2021): 153–57. http://dx.doi.org/10.25276/2312-4911-2021-1-153-157.

Full text

Abstract:

Purpose. To evaluate the clinical efficacy of using the angiogenesis inhibitor aflibercept in combination with the nutraceutical «Resvega Forte» in the treatment of neovascular age-related macular degeneration (nAMD) Material and methods. The clinical study involved 25 patients (25 eyes) with nAMD, who received 3 «loading» intravitreal injections of aflibercept (IIA) 2.0 mg (0.05 ml) at intervals of 1 time per month. Further, during the year, all patients received therapy according to the «heal and extend the interval» protocol. The patients of the main group (14 people) were supplemented with triple IIA with the administration of the «Resvega Forte» complex, 1 capsule 2 times a day for three months and then, after 6 months, continued with a second course. Patients of the comparison group (11 persons) did not receive the «Resvega Forte» complex. The central retinal thickness (CRT), the presence of detachment of the retinal pigment epithelium and neuroepithelium, subretinal, intraretinal or fluid under the pigment epithelium were assessed. Results. By the 12th month of observation, none of the patients of the main group against the background of two complexes «Resvega Forte» was found to have a resumption of disease activity. The maximum corrected visual acuity increased 3 times and amounted to 0.75±0.03 compared to the initial 0.25±0.06. The circulatory system in these patients on average corresponded to the norm – 254.6±11.3 µm. In the comparison group, the resumption of disease activity was noted twice, which was accompanied by a decrease in the functional and morphological parameters of the retina. Conclusion. The inclusion of the nutraceutical «Resvega Forte» in the treatment regimen allows not only to reduce the risk of progression of nAMD, but also to increase the functional and morphological parameters of the retina. An integrated approach makes it possible to increase the interval between injections and reduce the required number of them without additional monitoring, which reduces the burden on both the patient and the doctor. Key words: neovascular age-related macular degeneration, aflibercept, nutraceutical «Resvega forte».

APA, Harvard, Vancouver, ISO, and other styles

17

Choudhury, Rahat Anwer, Khondokar Anowar Hossain, Bijoy Kumar Saha, Munir Ahmed, and Md Nazrul Islam. "Diabetic Retinopathy Among Young Adults with Diabetes in a Rural Setting in Bangladesh: A Descriptive Cross-Sectional Study." Annals of International Medical and Dental Research 10, no. 1 (2024): 180–86. https://doi.org/10.53339/aimdr.2024.10.1.21.

Full text

Abstract:

Background: Diabetic retinopathy (DR) is one of the most important complications of type 1 diabetes mellitus, representing the leading cause of blindness in young adults. The aim of the study was to investigate the level of awareness and risk factors of DR in Young Adults with diabetes in the rural setting of Bangladesh. Material & Methods: The study was an observational and descriptive cross-sectional study. A total of 190 young adults DM patients were included in this study following the Fisher et al. 1991 formula. Study data were collected from January 2020 to December 2021. From type 1 diabetic enlisted patients under Faridpur diabetic samity attended for routine follow up in diabetic corner in Faridpur diabetic Association Medical College. Results: Half (48.9%) of diabetes patients aged between 6 to 18 years with a mean age of 19.03 ± 4.26 years, ranging from 6 to 29 years old. About 37.9% of patients were males and 62.1% of patients were females. The difference in age of DM patients by sex was found statistically significant at .02 level (x2 = 43.22, df = 11; Cramer’s V = .35). The average blood sugar was14.36±2.59 (fasting) and 16.58±2.85 (meal) of the young adults. There was an association between the age of the young adults and fasting blood sugar (x2=19.08, df=13, Sig.=0.05), however, there is no association between the age of the DM patients and the level of blood sugar (after breakfast) (x2=29.52, df=19, Sig.=0.08). About 41% of patients’ visual acuity (unaided) was 6/6-6/18 (16-20 years) and in the same age group, 5.3% of the young adults’ unaided visual acuity was <6/18-6/60. About 26.2% (21-25 years) of unaided visual acuity was 6/6-6/18 and 2.6% had <6/18-6/60 VA. However, about 47.4% of the patients VA (aided) of the age group 16-20 years had <6/18-6/60, 29.50% had VA <6/18-6/60 (age group 21-25 years), 4.2% of the patient (26-30%) had <6/18-6/60 vision and same age group 1.1% had <6/60-3/60 vision after correction. Refractive error, allergic condition/itching/red, conjunctivitis, Watering, foreign body, ocular injury, Corneal ulcer, Myopia, and Astigmatism was common eye problems of the DM patients in our study. The majority of the patients were prescribed medicine, spectacles, and surgery. Conclusions: The blood sugar level among young adults is alarming and physical inactivity and obesity are the main risk factors for its development. Community-level awareness programs and establish models of healthcare transition from pediatric to adult care to ensure continuity of care and avoid patient disengagement.

APA, Harvard, Vancouver, ISO, and other styles

18

Krinets, Zh M., and V. L. Krasilnikova. "RESULTS OF COMPREHENSIVE CONSERVATIVE TREATMENT OF PATIENTS WITH MEDIUM SEVERITY ENDOCRINE OPHTHALMOPATHY." Journal of the Grodno State Medical University 20, no. 1 (2022): 108–15. http://dx.doi.org/10.25298/2221-8785-2022-20-1-108-115.

Full text

Abstract:

Background. Pathogenetic therapy of the moderate severity endocrine ophthalmopathy (EOP) is performed by the administration of glucocorticoids (GC), which possess immunosuppressive, anti-inflammatory and anti-edematous effects. Currently, the application of selenium and pentoxifylline medications, as well as treatment with magnetic field over periorbital region are considered as a part of combined therapy for the disease. Purpose of the study. To evaluate the results of combined conservative treatment of patients with moderate severity EOP. Material and methods. The study included 25 patients (50 orbits) with the clinical signs of moderate severity EOP. Depending on the treatment regimen, patients were divided into group A (comparison) and group B (main). Group A (comparison) – 10 patients who received pulse therapy with methylprednisolone. Group B (main) – 15 patients who were prescribed a combination of pulse therapy with methylprednisalone and a new developed treatment regimen additionally: selenium 100 mgq 2 times a day for 6 months, pentoxifylline at a dose of 600 mg 2 times a day for 6 months, a low-frequency pulsed magnetic field generated by the "UniSPOK" apparatus, lasting for 10-20 minutes, up to 8-12 procedures performed daily. Methylprednisolone application in the form of intravenous pulse therapy was prescribed collegially by an endocrinologist and an ophthalmologist individually for each patient and in total did not exceed 4.5 g recommended for the present process intensity (on average, 4.5±0.5 g in both groups). Results. The sequence in decreasing of EOP clinical signs in patients receiving combination therapy was revealed: a decrease in tremor, eyelid edema and palpebral fissure width in comparison with the initial parameters were noted already by the 3rd month of treatment, after 6 months these indicators disappeared. Lacrimation in the studied groups was not recorded by the 6th month, which can be explained by the corticosteroids application. A significant reduction in exophthalmos under developed therapy was found after 6 months, while no reduction was observed in the standard treatment group. Conclusions. The method of EOP complex treatment, including pulse therapy with methylprednisolone in combination with selenium, pentoxifylline and magnetotherapy, was effective in the moderate severity of the disease and led to the reduction of the ophthalmopathy severity symptoms. The positive effect of the combined therapy indicates the necessity for a six-month treatment course.

APA, Harvard, Vancouver, ISO, and other styles

19

Storozhuk, O. B., I. B. Seleznyova, L. O. Storozhuk, T. M. Platonova, B. G. Storozhuk, and T. V. Dovgalyuk. "Some indicators of hemostasis and mortality from thrombotic complications in patients with CKD stage VD who were treated by programmed hemodialysis (five-year follow-up)." Reports of Vinnytsia National Medical University 25, no. 3 (2021): 409–12. http://dx.doi.org/10.31393/reports-vnmedical-2021-25(3)-10.

Full text

Abstract:

Annotation. Thrombotic complications in patients with stage VD chronic kidney disease (CKD), treated by program hemodialysis is one of the causes of high mortality in this category of patients; its major pathogenetic component proved to be hemostatic system disturbances characterized by systemic activation of blood clotting process leading to the development of thrombophilia. Objective – to study the biochemical molecular markers of hemostasis in patients with stage VD CKD, treated by program hemodialysis, and to determine their long-term effect on the development of thrombotic complications and mortality. The study included 88 patients (52 males and 36 females) aged 26 to 65 years with stage VD CKD, treated by program hemodialysis. The patients were followed up for five years. Soluble fibrin (sF) level was determined by two-site enzyme-linked immune-sorbent quantitative assay; D-dimer – by enzyme immunoassay using specific monoclonal antibodies to D-dimer epitopes; protein C (pC) activity in blood plasma was estimated by its activation with copperhead snake venom followed by spectrophotometry with wavelength 405 nm. Blood plasma fibrinogen was determined using thrombin-like enzyme Antsistron-H by spectrophotometry with wavelength 280 nm. Blood plasma fibrinolytic activity was evaluated by the relationship between D-dimer and soluble fibrin. Processing of materials was carried out using the methods of variation statistics and correlation analysis. During five years of follow up there were 13 deaths (14.8%), 7 among males and 6 among females, caused by thrombotic complications. The main thrombotic complications were myocardial infarction (6), ischemic stroke (4), mesenteric thrombosis (2) and disseminated intravascular coagulation syndrome (DIC) (1) (according to pathomorphological data). The patients of general group were found to have significantly increased sF level, decreased pC as compared to the control group, as well as twofold increase of fibrinogen concentration along with decreased D-dimer/sF ratio and no response of D-dimer to increased soluble fibrin level. The tendency of D-dimer/sF ratio to increase in those who died because of thrombotic complications could be indicative of microthrombosis with formation of fibrin derivatives along with mild activation of fibrinolysis. Correlation relationships between soluble fibrin and D-dimer, fibrinogen and protein C in general group were assessed, and the following data were obtained: medium direct relationship between soluble fibrin and D-dimer (r= 0.56) (p<0.001), and absence of correlation with fibrinogen (r= -0.12) and protein C (r= -0.10) (p˃0.1). Besides, strong positive correlation was demonstrated between D-dimer and soluble fibrin (r= 0.87) (p<0.001), and moderately negative one between D-dimer and protein C (r= -0.21) (p<0.05). It should be noted that in patients with thrombotic complications, positive correlations between soluble fibrin and D-dimer become stronger (r= 0.51) (p<0.001), as well as negative ones between soluble fibrin and protein C (r= -0.22) (p<0.05). Depressive state of anticoagulant component along with activation of coagulation factors are supposed to be one of the indicators predicting thrombophilia in this category of patients.

APA, Harvard, Vancouver, ISO, and other styles

20

Oliveira, Rafael, César Leão, Ana Filipa Silva, et al. "Comparisons between Bioelectrical Impedance Variables, Functional Tests and Blood Markers Based on BMI in Older Women and Their Association with Phase Angle." International Journal of Environmental Research and Public Health 19, no. 11 (2022): 6851. http://dx.doi.org/10.3390/ijerph19116851.

Full text

Abstract:

The aim of the present study was to compare electrical bioimpedance variables, blood markers and functional tests based on Body Mass Index (BMI) in older women. Associations between Phase Angle (PhA) with functional tests and blood markers were also analyzed. A total of 46 independent elderly people participated in the study, and they were divided into four groups according to BMI values: Group 1 (G1, BMI < 25 kg/m2); Group 2 (G2, BMI > 25–30 kg/m2); Group 3 (G3, BMI > 30–35 kg/m2); Group 4 (G4, BMI > 35 kg/m2). In addition to the weight and height used to calculate the BMI, the following body composition variables were collected: fat mass (FM), fat-free mass, intracellular water (ICW), extracellular water (ECW), total body water (TBW) and PhA (50 kHz) through InBody S10 equipment. Functional capacity was assessed using the Fullerton battery of tests: arm-curl; chair-stand; 6 min walking test (6MWT); time up-and-go test (TUG); standing on one leg (SOOL) and take 10 foot-lines (10FL). The main results showed differences between groups in the tests: 6MWT, SOOL and 10FL between G1 vs. G3 and G2 vs. G3 (p < 0.05); ACT, AIC and AEC between G1 vs. G4 (p < 0.05); FM among all groups (p < 0.05). Negative correlations were found between PhA and the agility test in G1 (r = −0.848; p = 0.008) and G4 (r = −0.909; p = 0.005); PhA and chair-stand in G3 (r = 0.527; p = 0.044); PhA and forearm flexion in G3 (r = 0.641; p = 0.010) and G4 (r = 0.943; p = 0.001); PhA and 6MWT in G4 (r = 0.771; p = 0.042). This study found that there is a clear trend towards better functional capacities with better parameters of body composition. Although there were no differences between groups in PhA, associations were found between different functional tests with PhA, which reveals the importance of this variable as a marker of health status.

APA, Harvard, Vancouver, ISO, and other styles

21

Derevtsov, Vitaly V., Evgeniy V. Neudakhin, Liudmila K. Antonova та ін. "Assessment оf the state оf compensatory resources and the dеgrее оf adaptation оf the body tо environmental conditions in full-term infants: cross-sectional study". Pediatrics. Consilium Medicum, № 1 (10 травня 2022): 20–27. http://dx.doi.org/10.26442/26586630.2022.1.201415.

Full text

Abstract:

Aim. Assessment of the state of compensatory resources and the degree of adaptation of the body to environmental conditions in early and full-term infants in comparison with each other and with practically healthy children. Materials and methods. Under the supervision of 135 infants. 110 were born from mothers with a burdened somatic and obstetric-gynecological history, 41 of them were born at 3738 weeks (Group 1), 69 at 3942 weeks (Group 2). The control group (Group 3) consisted of 25 practically healthy children born to practically healthy mothers as a result of physiological pregnancies and childbirth at 3840 weeks. The children were examined in dynamics at the age of 1 (n=126), 3 (n=116), 6 (n=110), 12 (n=111) months. A comprehensive analysis of the data of anamnesis, physical examination, cardiointervalography was carried out. The following parameters were evaluated initially and in response to the tilt test: mode (М0), mode amplitude (AM0), delta x (∆Х), voltage index (IN). Nonparametric methods of statistical analysis were used. Results. At the age of 2 to 3 days infants born to women with a history of poor health recorded a significant decrease in the median IN1 value, respectively, in Groups 1, 2, and 3, which indicates a decrease in compensatory reserves, particularly in neonates born at 3840 weeks. At 1 month of age, Group 1 and 2 had higher median IN1 values of 804 and 746 versus 550 in Group 3, indicating the development of compensatory resource tension, particularly in children born at 3738 weeks. At 3 months of age, children in group 1 retained a compensatory tension of IN1 resources 521 versus 468 and 460 in groups 2 and 3. At 6 months of age, there is a slight decrease in compensatory IN1 reservers at 6 months of age in children from women with a history of a history of a history of a history of a disease 376 and 357 versus 400 in Group 3. At 12 months of age, children in the main groups have even more decreased compensatory resources, especially in group 1 IN1 206, 284 and 380 respectively in groups 1, 2 and 3. Conclusion. The decrease of functional reserve of adaptation in children of groups 1st and 2nd was facilitated by the influence burdened with somatic and obstetric-gynecological history of mothers, regardless of gestational age and subsequently the health characteristics of children themselves. The statistically significant differences found in the state of compensatory resources and the degree of adaptation of the organism to environmental conditions justify the personalized approach, which justifies a personalized approach when choosing rehabilitation measures.

APA, Harvard, Vancouver, ISO, and other styles

22

Kavanagh, Meaghan E., Laura Chiavaroli, Selina M. Quibrantar, et al. "Acceptability of a Web-Based Health App (PortfolioDiet.app) to Translate a Nutrition Therapy for Cardiovascular Disease in High-Risk Adults: Mixed Methods Randomized Ancillary Pilot Study." JMIR Cardio 9 (March 28, 2025): e58124. https://doi.org/10.2196/58124.

Full text

Abstract:

Background The Portfolio Diet is a dietary pattern for cardiovascular disease (CVD) risk reduction with 5 key categories including nuts and seeds; plant protein from specific food sources; viscous fiber sources; plant sterols; and plant-derived monounsaturated fatty acid sources. To enhance implementation of the Portfolio Diet, we developed the PortfolioDiet.app, an automated, web-based, multicomponent, patient-facing health app that was developed with psychological theory. Objective We aimed to evaluate the effect of the PortfolioDiet.app on dietary adherence and its acceptability among adults with a high risk of CVD over 12 weeks. Methods Potential participants with evidence of atherosclerosis and a minimum of one additional CVD risk factor in an ongoing trial were invited to participate in a remote web-based ancillary study by email. Eligible participants were randomized in a 1:1 ratio using a concealed computer-generated allocation sequence to the PortfolioDiet.app group or a control group for 12 weeks. Adherence to the Portfolio Diet was assessed by weighed 7-day diet records at baseline and 12 weeks using the clinical Portfolio Diet Score, ranging from 0 to 25. Acceptability of the app was evaluated using a multifaceted approach, including usability through the System Usability Scale ranging from 0 to 100, with a score >70 being considered acceptable, and a qualitative analysis of open-ended questions using NVivo 12. Results In total, 41 participants were invited from the main trial to join the ancillary study by email, of which 15 agreed, and 14 were randomized (8 in the intervention group and 6 in the control group) and completed the ancillary study. At baseline, adherence to the Portfolio Diet was high in both groups with a mean clinical Portfolio Diet Score of 13.2 (SD 3.7; 13.2/25, 53%) and 13.7 (SD 5.8; 13.7/25, 55%) in the app and control groups, respectively. After the 12 weeks, there was a tendency for a mean increase in adherence to the Portfolio Diet by 1.25 (SD 2.8; 1.25/25, 5%) and 0.19 (SD 4.4; 0.19/25, 0.8%) points in the app and control group, respectively, with no difference between groups (P=.62). Participants used the app on average for 18 (SD 14) days per month and rated the app as usable (System Usability Scale of mean 80.9, SD 17.3). Qualitative analyses identified 4 main themes (user engagement, usability, external factors, and added components), which complemented the quantitative data obtained. Conclusions Although adherence was higher for the PortfolioDiet.app group, no difference in adherence was found between the groups in this small ancillary study. However, this study demonstrates that the PortfolioDiet.app is considered usable by high-risk adults and may reinforce dietitian advice to follow the Portfolio Diet when it is a part of a trial for CVD management. Trial Registration ClinicalTrials.gov NCT02481466; https://clinicaltrials.gov/study/NCT02481466

APA, Harvard, Vancouver, ISO, and other styles

23

Canti, V., G. Inguscio, N. P. Tenace, et al. "AB0445 THE BENEFICIAL EFFECTS OF THERAPY ON OBSTETRICAL OUTCOME AND PLACENTAL HISTOLOGY IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME: THE EXPERIENCE OF A SINGLE ITALIAN REFERENCE CENTER." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1351.1–1351. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4543.

Full text

Abstract:

BackgroundAbnormal placentation plays a crucial role in the pathogenesis of obstetric morbidity in antiphospholipid antibodies syndrome (APS). Placenta is the main target of aPL in obstetric APS, inducing placental thrombosis, inflammatory response and placental dysfunction.Standard treatment for APS patients during pregnancy includes low-dose aspirin (LDA) plus low molecular weight heparin (LMWH) and, in refractory cases, additional therapies such as hydroxychloroquine (HCQ).A systematic review of the literature has found five main pathological lesions in the placenta of APS patients: placental infarction, decidual vasculopathy, decidual inflammation, increase of syncytial knots due to syncytiotrophoblast death, and decrease in vasculosyncytial membranes.ObjectivesTo analyze placental histology in a group of 23 spontaneously conceived pregnancies in patients with definite APS prospectively followed in a single Italian reference center.MethodsWe analyzed 25 placenta in 23 spontaneously conceived pregnancies in patients with definite APS prospectively followed in the ‘Pregnancy at risk’ multidisciplinary outpatient clinics at San Raffaele Hospital, Milan, Italy from January 2017 to May 2021. During each trimester of gestation, ultrasonography with Uterine artery Doppler velocimetry was performed. Histological analysis of the placenta was carried out after delivery and placental tissues were examined for the main aforementioned histopathological findings. Statistical relations among clinical and ultrasound evaluations during each trimester, therapeutic approach and placental histology were performed.Results19/25 (76%) patients had primary APS, while 6 patients had APS secondary to SLE. All patients were treated with LDA and LMWH. HCQ was added in a group of patients with concomitant systemic lupus erythematosus (SLE) or in refractory APS. Mean placental weight was 441 ± 129 grams. Histological analysis of placental tissues revealed increased syncytial knots in 17/25 (68%) placenta, decreased vasculosyncytial membranes in 11/25 (44%), infarction in 8/25 (32%), presence of macrophages and decidual inflammation in 2/25 (8%), and atherosis or reduction of spiral arteries remodelling in 3/25 (12%) placenta. Moreover, we observed at least 2 concomitant placental lesions in 12/25 (48%) placentas.No statistical association between mean UtA-PI values and the number and type of placental lesions described at the histologic analysis were observed. We found a positive correlation between mean titer of aCL IgG, aβ2GPI IgG, aPS/PT IgM and/or aPS/PT IgG and number of placental lesions, and a significant association between aPS/PT IgM and/or IgG mean titer and presence of infarcted areas at placental histology. Moreover, in the placenta of patients treated with HCQ we did not observe any decidual inflammation at histology.ConclusionIn our study we found some important clinical-pathological correlations between placental histology, clinical evaluations, ultrasound assessments and treatment received during pregnancy. Specifically, it is tempting to speculate that HCQ may have beneficial effects on pregnancy by decreasing the risk of deciduitis in patients with APS.Further studies on larger numbers of placenta in APS patients will be needed to confirm our findings.References[1]Viall CA, Chamley LW. Histopathology in the placentae of women with antiphospholipid antibodies: A systematic review of the literature. Autoimmun Rev. 2015 May;14(5):446-71.Disclosure of InterestsNone declared

APA, Harvard, Vancouver, ISO, and other styles

24

Rahman, Mohammad Mizanoor, Md Ashraful Anam, Md Mohim Ibn Sina, Md Aminur Rahman, Mohammad Nasir Uddin, and Mohammad Mahbubur Rahman. "Comparison of Haemodynamic Effects of Levobupivacaine and Bupivacaine in Sub-arachnoid Block for Total Abdominal Hysterectomy." Medicine Today 32, no. 1 (2020): 29–32. http://dx.doi.org/10.3329/medtoday.v32i1.44825.

Full text

Abstract:

Introduction: Altered haemodynamics and arterial hypotension are the most prevalent untoward effects of sub-arachnoid block with bupivacaine. Use of levobupivacaine as pure S (-) - enantiomer of bupivacaine has progressively increased due to its lower cardiotoxicity, neurotoxicity and shorter duration of motor block. This study aimed to compare the haemodynamic status of levobupivacaine and bupivacaine when used with fentanyl in Sub-arachnoid block (SAB) among patients undergone total abdominal hysterectomy. Materials and Methods: This randomized clinical trial enrolled 80 gynaecological patients scheduled for total abdominal hysterectomy under SAB. Forty patients were randomly assigned as trial group (levobupivacaine+fentanyl) and forty as control group (bupivacaine+fentanyl). Main outcome measures in both groups considered intraoperative haemodynamic stability (acute hypotension), cardiotoxicity (bradycardia or tachycardia) and time of administration of first dose of postoperative analgesics. Results: Bupivacaine caused comparatively more significant slowing of heart rate at 25 and 35 minutes of operation. Though no significant differences were found in systolic blood pressure between two groups, bupivacaine caused significant reduction of diastolic blood pressure in comparison to levobupivacaine at 6, 9, 45 minutes and at the end of surgery. Mean pressure found significantly lowered at 6 minutes and at the end of surgery following bupivacaine administration. The incidence of acute hypotension was significantly low in trial group and postoperative analgesia was maintained longer duration with levobupivacaine in control group. Conclusion: Levobupivacaine in comparison to bupivacaine showed more effective and satisfactory haemodynamic stability in sub-arachnoid block with less incidence of intraoperative acute hypotension and provides prolonged postoperative analgesic effect. Medicine Today 2020 Vol.32(1): 29-32

APA, Harvard, Vancouver, ISO, and other styles

25

Laudner, Kevin G., Melissa Wenig, Noelle M. Selkow, Jeffrey Williams, and Eric Post. "Forward Shoulder Posture in Collegiate Swimmers: A Comparative Analysis of Muscle-Energy Techniques." Journal of Athletic Training 50, no. 11 (2015): 1133–39. http://dx.doi.org/10.4085/1062-6050-50.11.07.

Full text

Abstract:

Context Empirical data for treating forward shoulder posture supports stretching the anterior shoulder musculature. Although muscle-energy techniques (METs) have been hypothesized to lengthen muscle, no data have described the usefulness of this technique among swimmers. Objective To determine if an MET provides improvements in resting pectoralis minor length (PML), forward scapular position, and scapular upward rotation in female collegiate swimmers. Design Controlled laboratory study. Setting Athletic training room. Patients or Other Participants Thirty-nine asymptomatic National Collegiate Athletic Association Division I women's swimmers (19 experimental, 20 control). Intervention(s) The experimental group received 2 treatment sessions per week for 6 weeks. The control group received no intervention during this 6-week period. Main Outcome Measure(s) We administered pretest and posttest measurements for PML, forward scapular position, and scapular upward rotation in positions of rest and 60°, 90°, and 120° of humeral elevation. The MET consisted of a 3-second stretch in the direction of the pectoralis minor fibers, followed by a 5-second isometric horizontal adduction contraction at 25% of maximum force. Immediately after this contraction, the entire sequence was repeated with the muscle being stretched to the new endpoint. A total of 4 cycles of MET were continuously applied per treatment session twice per week for 6 weeks. We conducted 1-way analyses of covariance to determine any between-groups postintervention test differences. Results The MET group had a greater increase in PML postintervention (P = .001, effect size = 1.6) and a greater decrease in forward scapular position postintervention (P = .001, effect size = 1.07) compared with the control group. No differences were found for scapular upward rotation (P &gt; .10). Conclusions Our results indicate that 6 weeks of MET treatments applied to the pectoralis minor of asymptomatic female swimmers provided improvements in PML and forward scapular position compared with a control group.

APA, Harvard, Vancouver, ISO, and other styles

26

Zhang, Xiangyu, Shilan Wang, Yujun Wu, Xiaoyi Liu, Junjun Wang, and Dandan Han. "Ellagic Acid Alleviates Diquat-Induced Jejunum Oxidative Stress in C57BL/6 Mice through Activating Nrf2 Mediated Signaling Pathway." Nutrients 14, no. 5 (2022): 1103. http://dx.doi.org/10.3390/nu14051103.

Full text

Abstract:

Ellagic acid (EA) is the main constituent found in pomegranate rind, which has anti-inflammatory and antioxidant effects. However, whether EA can alleviate diquat-induced oxidative stress is still unknown. Here, the effects and mechanisms of EA on jejunum oxidative stress induced by diquat was investigated. Oxidative stress was induced in mice by administrating diquat (25 mg/kg body weight) followed by treatment with 100 mg/kg body weight EA for 5 days. Results showed that oral administration of EA significantly ameliorated diquat-induced weight loss and oxidative stress (p < 0.05) evidenced by reduced ROS production in the jejunum. Furthermore, EA up-regulated the mRNA expression of the antioxidant enzymes (Nrf2, GPX1 and HO-1) when mice were challenged with diquat, compared with the diquat group (p < 0.05). Importantly, pharmacological inhibition of Nrf2 by ML385 counteracted the EA-mediated alleviation of jejunum oxidative stress, as evidence by body weight and ROS production. Also, immunohistochemistry staining confirmed the markedly decreased jejunal Nrf2 expression. The up-regulated effect on NQO1 and HO-1 mRNA expression induced by EA was diminished in mice treated with ML385 (p < 0.05). Together, our results demonstrated that therapeutic and preventative EA treatment was effective in reducing weight loss and oxidative stress induced by diquat through the Nrf2 mediated signaling pathway.

APA, Harvard, Vancouver, ISO, and other styles

27

Schiller, Joerg, Matthias Karst, Tim Kellner, et al. "Combination of acupuncture and medical training therapy on tension type headache: Results of a randomised controlled pilot study." Cephalalgia 41, no. 8 (2021): 879–93. http://dx.doi.org/10.1177/0333102421989620.

Full text

Abstract:

Objectives The aim of this study was to compare the effects of acupuncture and medical training therapy alone and in combination with those of usual care on the pain sensation of patients with frequent episodic and chronic tension-type headache. Design This was a prospective single-centre randomised controlled trial with four balanced treatment arms. The allocation was carried out by pre-generated randomisation lists in the ratio 1:1:1:1 with different permutation block sizes. Setting The study was undertaken in the outpatient clinic of Rehabilitation Medicine of the Hannover Medical School. Participants and interventions: Ninety-six adult patients with tension-type headache were included and randomised into usual care (n = 24), acupuncture (n = 24), medical training (n = 24), and combination of acupuncture and medical training (n = 24). One patient was excluded from analysis because of withdrawing her/his consent, leaving 95 patients for intention to treat analysis. Each therapy arm consisted of 6 weeks of treatment with 12 interventions. Follow-up was at 3 and 6 months. Main outcome measures Pain intensity (average, maximum and minimum), frequency of headache, responder rate (50% frequency reduction), duration of headache and use of headache medication. Clinical results: The combination of acupuncture and medical training therapy significantly reduced mean pain intensity compared to usual care (mean = −38%, standard deviation = 25%, p = 0.012). Comparable reductions were observed for maximal pain intensity (−25%, standard deviation = 20%, 0.014) and for minimal pain intensity (−35%, standard deviation = 31%, 0.03). In contrast, neither acupuncture nor medical training therapy differed significantly from usual care. No between-group differences were found in headache frequency, mean duration of headache episodes, and pain medication intake. At 3 months, the majority of all patients showed a reduction of at least 50% in headache frequency. At 6 months, significantly higher responder rates were found in all intervention groups compared to usual care. Conclusions In contrast to monotherapy, only the combination of acupuncture and medical training therapy was significantly superior in reduction of pain intensity compared to usual care. Trial registration: Registered on 11 February 2019. German Clinical Trials Register, DRKS00016723.

APA, Harvard, Vancouver, ISO, and other styles

28

Siswandi, S., and Firman Rizaldi. "An Experimental Study: Cartoon Videos as Media Instruction on Students Speaking Ability." Indonesian Journal of Integrated English Language Teaching 7, no. 1 (2021): 55. http://dx.doi.org/10.24014/ijielt.v7i1.13775.

Full text

Abstract:

The main focus of this research is to investigate whether there was a significant difference in the speaking ability between the tenth grade students of SMA N 1 Kampar Timur. This research was classified as a quasi-experimental study. It involved 65 students of two groups, Class X MIPA 5 as the experimental group and Class X MIPA 6 as the control group. The experimental group was taught by using cartoon videos, whereas the control group was taught by using the textbook-based technique. The data were obtained by using a pre-test and a post-test. The pre-test was given to both groups before the treatment and the post-test was given after the treatment. The data of the pre-test and post-test of both groups were analyzed by using descriptive and inferential statistics. The data were calculated by using a computer program, SPSS 25 for Windows. After the data were tested and found to be homogeneous and normal, the hypothesis was tested using the Kolmogrov-Smirnov test. The results of the research show that there was a significant difference in the speaking ability between the students who were taught by using cartoon video and those who were taught by using the textbook-based technique. The significance value calculated 0.019 is bigger than 0.05 (sig value=0.109>0.05). Therefore, the hypothesis of this study is rejected. It means that there is no significant difference on students speaking ability who are taught by cartoon video as instructional media at the eleventh grade of senior high school 1 Kampar Timur.

APA, Harvard, Vancouver, ISO, and other styles

29

Agraso Busto, Sara, Vanesa Varela, Natalia Fernández Núñez, et al. "Real-world clinical experience of the Galician Lung Cancer Group: Afatinib in patients with EGFR positive mutation." Journal of Clinical Oncology 37, no. 15_suppl (2019): e20654-e20654. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e20654.

Full text

Abstract:

e20654 Background: Treatment with tyrosine kinasa inhibitors has been a revolution for the patients with non-small cell lung cancer and EGFR positive mutation, especially in patients with exon 19 deletions. Afatinib seems one of the best options of treatment. Methods: Retrospective study on patients from differents hospitals in Galicia (Spain) diagnosed of metastasic lung adenocarcinoma with EGFR positive mutation who have received first line treatment with afatinib between July 2015 and September 2018 were included. The main objective was to compare our clinical experience concerning response rate, progression free survival and toxicity with published data. Results: 45 caucasians patients were included in our analysis (33 women, 12 men). Median age was 71.2 years (range 39-91 years) and 29 patients had never smoked. Exon 19 deletion was the most common mutation (41 patients, 91.1%). The objective overall response was 68.9% (95% CI: 82.4-55.3), complete responses were observed in 6 patients (13.3%) and partial responses were found in 25 patients (55.6%). Stable disease was observed in 8 patients (17.8%) and disease progression in 1 patient (2.2%), 5 patients have not been re-evaluated (11.1%). Median progression free survival (PFS) was 27 months (95% CI: 14.8-39.1) and overall survival was not reached. Common adverse events grade 3/4 were mucositis and skin toxicity in 11 patients (24.4%) and diarrhea in 6 patients (13.3%), respectively. The dose was reduced in 28 patients (62.2%) and treatment was discontinued in 8 patients (17.8%) owing to adverse events. Conclusions: Median PFS in our patients is 15 months longer than the information retrieved from differents studies with similar response rates and toxicity. This might be due to a majority of population with exon 19 deletion which, according to published data, seems to benefit more from afatinib than from other EGFR mutations.

APA, Harvard, Vancouver, ISO, and other styles

30

Bezmenko, Alexander A., Natalia D. Sadovaya, Marina E. Meshkova, and Elena A. Malakhova. "Cytokine profile in women with threatened miscarriage and intestinal dysbiosis." Journal of obstetrics and women's diseases 70, no. 1 (2021): 51–58. http://dx.doi.org/10.17816/jowd48554.

Full text

Abstract:

Hypothesis/Aims of study: Systemic endotoxinemia resulting from intestinal dysbiosis activates the Th1 immune response and excessive production of proinflammatory cytokines, which can cause abortion. This study was aimed at assessing interleukin levels in women with the threat of miscarriage and exploring their dependence on intestinal microbiocenosis and the level of endotoxinemia. Study design, materials and methods: The study involved 87 women aged 18 to 43 years in pregnancy from six to 22 weeks. The main group consisted of 50 women with a threatened miscarriage. The control group included 37 women with normal pregnancy. A qualitative and quantitative analysis of intestinal microbiocenosis was performed by real-time PCR, with endotoxin and interleukin levels evaluated using conventional methods. Results: In patients of the main group, intestinal dysbiosis of grade I was detected in 30 % (n = 15), of grade II in 46 % (n = 23), and of grade III in 24 % (n = 12) of cases. In the control group, intestinal microflora disorders corresponded to grade I dysbiosis in 67.6 % (n = 25) and grade II dysbiosis in 32.4 % (n = 12) of cases, there being no cases of severe dysbiosis revealed. The level of endotoxin in pregnant women of the main group was 0.57 0.02 nmol / ml and was classified as increased. The endotoxin level in the blood serum of pregnant women of the control group was 0.34 0.02 nmol / ml and was characterized as low (p 0.001). A strong correlation was found (r = 0.8, p 0.001) between the grade of intestinal dysbiosis and the level of endotoxinemia. The cytokine profile in patients of the main group was characterized by increased concentrations of pro-inflammatory cytokines (IL-1 4.9 1.6 pg / ml, IL-6 4.8 1.5 pg / ml) and a decreased concentration of anti-inflammatory cytokine (IL-10 18.0 4.5 pg / ml), when compared to the control group (IL-1 1.8 0.2 pg / ml, IL-6 2.1 0.2 pg / ml, IL-10 30.3 4.4 pg/ml). There were a statistically significant moderate positive correlation between the level of endotoxinemia and the concentration of pro-inflammatory cytokines and a weak negative correlation between the endotoxin level and the concentration of anti-inflammatory IL-10. Conclusion: Endotoxinemia, which occurs as a result of intestinal microflora dysbiosis and activates pro-inflammatory pathways, can really be as a triggering factor in the pathogenesis of miscarriage in pregnant women.

APA, Harvard, Vancouver, ISO, and other styles

31

Bu, Juan, Yanmin Zhang, Yeledan Mahan, et al. "Acacetin improves cognitive function of APP/PS1 Alzheimer’s disease model mice via the NLRP3 inflammasome signaling pathway." Translational Neuroscience 13, no. 1 (2022): 390–97. http://dx.doi.org/10.1515/tnsci-2022-0254.

Full text

Abstract:

Abstract Background Acacetin (5,7-dihydroxy-4′-methoxyflavone), one of the main extractions from Saussurea involucrata, has anti-inflammatory effects. Our previous study found that acacetin inhibited the Nod-like receptor pyrin domain containing 3 (NLRP3) signaling pathway after cerebral ischemia–reperfusion injury. NLRP3 inflammasome plays a role in Alzheimer’s disease (AD) process. However, few studies have examined the effects of acacetin in AD. Methods We randomly divided APP swe/PS1dE9 double transgenic mice into acacetin group (intraperitoneal injection of 25 mg/kg acacetin) and AD model group (intraperitoneal injection of same volume of saline). C57BL/6 mice were selected as control group (same treatment with AD model group). After treating for 30 days, a Morris water maze test was conducted to evaluate spatial learning and memory of the mice. Senile plaque (SP) formation was evaluated by immunohistochemistry. NLRP3 inflammasome-related inflammatory factors and amyloid-β-42 were detected by Western blot or enzyme-linked immunosorbent assay. Results Acacetin improved spatial learning and memory of AD mice and reduced APP/β expression, thereby decreasing SP formation in the brain. Acacetin also reduced the expression of NLRP3, cysteinyl aspartate-specific proteinase 1 (caspase-1), and interleukin-1β (IL-1β) and the release of inflammatory factors, tumor necrosis factor-α (TNF-α) and IL-1β. Conclusions Acacetin improved the learning and memory abilities of AD mice and exerted a protective effect on AD by inhibiting the NLRP3 signaling pathway and reducing SP formation.

APA, Harvard, Vancouver, ISO, and other styles

32

Rockenbach, Mathias F., Aline C. Velho, Amanda E. Gonçalves, Pedro E. Mondino, Sandra M. Alaniz, and Marciel J. Stadnik. "Genetic Structure of Colletotrichum fructicola Associated to Apple Bitter Rot and Glomerella Leaf Spot in Southern Brazil and Uruguay." Phytopathology® 106, no. 7 (2016): 774–81. http://dx.doi.org/10.1094/phyto-09-15-0222-r.

Full text

Abstract:

Colletotrichum fructicola is the main species causing apple bitter rot (ABR) and Glomerella leaf spot (GLS) in southern Brazil, and ABR in Uruguay where GLS remains unnoticed. Thus, this work aimed to determine the genetic structure of C. fructicola isolates of both the countries. A total of 28 out of 31 Brazilian isolates (90.3%) caused typical symptoms of GLS, while only 6 of 25 Uruguayan isolates (24.0%) originating from fruits were able to infect leaves, but causing atypical symptoms. Both populations showed similar levels of Nei’s gene diversity (h = 0.088 and 0.079, for Brazilian and Uruguayan populations, respectively), and Bayesian cluster analysis inferred two genetic clusters correlated with the geographical origin of isolates. A principal coordinates analysis scatter plot and an unweighted pair group method with arithmetic mean-based dendrogram also grouped Brazilian and Uruguayan isolates into two groups. By pairwise comparison of nitrate-nonutilizing (nit) mutants with a proposed set of testers, all Uruguayan isolates were grouped into a unique vegetative compatibility group (namely VCG 1), while Brazilian isolates were grouped into four VCGs (VCG 1 to 4). Brazilian and Uruguayan populations of C. fructicola were found to be genetically distinct. Our results suggest that isolates of C. fructicola from Brazil capable of causing GLS and ABR arose independently of those from Uruguay. Possible causes leading to the evolutionary differences between populations are discussed.

APA, Harvard, Vancouver, ISO, and other styles

33

Mazza, S., A. Fascì, V. Casini, et al. "P360 Safety and clinical efficacy of double switch from originator infliximab to biosimilars CT-P13 and SB2 in patients with inflammatory bowel diseases (SCESICS): A multicentre study." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S342. http://dx.doi.org/10.1093/ecco-jcc/jjz203.489.

Full text

Abstract:

Abstract Background Since infliximab (IFX) patent expiry in 2015, several IFX biosimilars have been licensed in EU for all indications, including inflammatory bowel diseases (IBD). IFX biosimilars currently available in Italy include CT-P13 and SB2, both of which demonstrated comparable efficacy, safety and immunogenicity with IFX originator in IBD patients. Safety and clinical efficacy of single switch from originator IFX to CT-P13 have also been confirmed in a prospective clinical trial. On the contrary, data regarding multiple therapeutic switching of IFX originator with CT-P13 and SB2 are currently lacking. Methods This study was aimed to evaluate the safety and efficacy of double switch from IFX originator to CT-P13 and subsequently to SB2 in patients with IBD. From November 2018 to May 2019, patients undergoing IFX double switch in 8 Centres in Lombardy were retrospectively analysed. The overall rate of IFX discontinuation, incidence and type of adverse events (AE) and proportion of patients on clinical remission over time were recorded. Data were compared with a control group of 66 IBD patients single switched from IFX originator to CT-P13. Results Fifty-two double-switched IBD patients were enrolled (63% M, mean age 41 years, 75% Crohn’s disease, 25% ulcerative colitis). Main indications for IFX therapy were moderate to severe disease (50%) and steroid-dependent disease (25%). The overall 24- and 48-week IFX discontinuation rates following second switch (CTP13-&gt;SB2) were 2% (95% CI 0–6%) and 14% (95% CI 3–25%), respectively. During a median follow-up of 40 weeks (18–48), 4 patients (12%) experienced a total of 6 AE (2 cutaneous, 2 infectious, 1 articular and 1 immunological), leading to IFX discontinuation in 3 cases (6%). No infusion reactions were observed. At week 24 following second switch, 49 (94%) patients were in clinical remission, the remaining 3 patients not being in remission already at the time of second switch. Only one patient lost response after week 24, 48 (92%) of patients being in clinical remission at the end of follow-up. No differences in IFX discontinuation, AE and clinical remission rates were found between double-switched and single-switched patients. No clinical parameters were found to predict safety and efficacy outcomes. Conclusion The study supports both safety and efficacy of the double switch from IFX originator to CT-P13 and SB2 in patients with IBD, and demonstrates its non-inferiority to a single switch strategy, with potential cost implications.

APA, Harvard, Vancouver, ISO, and other styles

34

Abdullayeva, A. Ə. "ПЕРИОДИЧЕСКИЕ ПАРАМЕТРЫ ВАРИАБЕЛЬНОСТИ СЕРДЕЧНОГО РИТМА ПРИ ИДИОПАТИЧЕСКОЙ БЛОКАДЕ ПРАВОЙ НОЖКИ ПУЧКА ГИСА У ДЕТЕЙ". Azerbaijan Medical Journal, № 3 (30 вересня 2023): 5–8. http://dx.doi.org/10.34921/amj.2023.3.001.

Full text

Abstract:

Məqalədə Hiss dəstəsinin sağ ayaqcığının idiopatik blokadası (HDSAB) olan uşaqlarda ürək ritminin variabelliyinin (ÜRV) dövri parametrlərini öyrənmək məqsədilə aparılmış tədqiqat işi haqqında məlumat verilmişdir. Tədqiqata uşaq yaşının dövrlərini və yaş xüsusiyyətlərini nəzərə alaraq 82 nəfər uşaq cəlb edilmişdir. Bu uşaqlar 3-6 yaşlı və 12-17 yaşlı olmaqla 2 qrupa bölünmüşdür. Hər bir qrupda HDSAB olan əsas qrup uşaqlar müvafiq yaşlı praktik sağlam olan kontrol qrup uşaqlarla müqayisə edilmişdir. Bunlardan HDSAB-sı olan 3-6 yaşlı 14 uşaq (7 oğlan, 7 qız) 1-ci qrupun əsas qrupuna, 3-6 yaşlı 11 praktik sağlam uşaq isə kontrol qrupuna daxil edilmişdir. HDSAB olan 12-17 yaşlı 43 uşaq (27-oğlan, 16-qız) 2-ci qrupun əsas qrupuna, 12-17 yaşlı 14 praktik sağlam uşaq isə kontrol qrupuna daxil edilmişdir. Alınmış nəticələrin təhlili göstərmişdir ki, HDSAB olan uşaqlarda ÜRV-nin dövri parametrlərini öyrənməklə vegetativ sinir sisteminin simpatik və parasimpatik şöbələri arasında disbalansı aşkar etmək mümkündür. Bu isə HDSAB olan uşaqlarda ürək damar sistemi patalogiyalarının və onların ağırlaşmalarının qarşısının alınmasında əhəmiyyətli ola bilər. В статье представлена информация об исследовании проведенном с целью изучения периодических (временных) параметров вариабельности сердечного ритма (ВСР) у детей с идиопатической блокадой правой ножки пучка Гиса (БПНПГ). В исследовании приняли участие 82 детей с БПНПГ, разделенные на 2 группы: 14 детей в возрасте 3-6 лет (7 мальчиков, 7 девочек), 43 детей в возрасте 12-17 лет (27 мальчиков, 16 девочек), а остальные 25 – практически здоровые дети соответствующего возраста (11 детей в возрасте 3-6 лет, 14 детей - 12-17 лет), которые вошли в контрольную группу. У детей с БПНПГ выявлены определенные тенденции в показателях ВСР по сравнению со здоровыми детьми в обеих группах: Показатели ВСР отражали преобладание симпатического тонуса у детей с 1-й группой БПНПГ (3-6 лет) и повышение парасимпатической активности у детей со 2-й группой (12-17 лет) БПНПГ. Анализ полученных результатов показывает, что выявление дисбаланса между симпатическими и парасимпатическими ветвями вегетативной нервной системы возможно при изучении периодических параметров ВСР у детей с БПНПГ. Это может иметь важное значение для профилактики сердечно-сосудистых патологий и их осложнений у детей с БПНПГ. The article provides information on the research conducted to study the periodic parameters of heart rhythm variability (HRV) in children with idiopathic right bundle branch block (RBBB). 82 children were involved in the study, taking into account the periods of childhood and age characteristics. These children are divided into 2 groups, 3-6 years old and 12-17 years old. In each group, the main group of children with RBBB were compared with the practically healthy control group children of the corresponding age. Of these, 14 children (7 boys, 7 girls) aged 3-6 with RBBB were included in the main group of the 1st group, and 11 practically healthy children aged 3-6 were included in the control group. 43 children aged 12-17 with RBBB (27 boys, 16 girls) were included in the main group of the 2nd group, and 14 practically healthy children aged 12-17 were included in the control group. In children with RBBB, certain trends in the indicators of HRV were found compared to healthy children in both groups. The indicators of HRV reflected the predominance of sympathetic tone in children with 1st group RBBB (3-6 years old), and the increase of parasympathetic activity in children with 2nd group (12-17 years old) RBBB. The analysis of the obtained results shows that it is possible to detect the imbalance between the sympathetic and parasympathetic departments of the autonomic nervous system by studying the periodic parameters of the HRV in children with RBBB. This can be important in preventing cardiovascular pathologies and their complications in children with RBBB.

APA, Harvard, Vancouver, ISO, and other styles

35

Wani, Nadia Irshad, Navneet Kour, and Manju Verma. "Evaluation and Comparison of Formocresol and Sodium Hypochlorite as Pulpotomy Medicaments in Treatment of Mandibular Primary Molars - A Randomized Controlled Study." International Journal of Science and Healthcare Research 6, no. 4 (2021): 105–10. http://dx.doi.org/10.52403/ijshr.20211017.

Full text

Abstract:

Background: the main idea behind the pulpotomy of a primary tooth is to remove the infected or inflamed coronal pulp tissues and cover the pulp with a suitable medicament or dressing which promotes healing and preserve the vitality of the teeth especially in young permanent teeth. A medicament should be biologically compatible, have healing capabilities, should be non cytotoxic, or mutagenic and with no carcinogenic potential. Aim: the main aim of the study was to compare and evaluate the efficacy of commonly used two medicaments i.e. formocresol and sodium hypochlorite in pulpotomy of mandibular primary teeth. Material and methodology: a randomized controlled single blinded clinical trial was done on 50 subjects of age ranging from 3 to 6 years with bilateral mandibular first or second molar requiring pulpotomy. The subjects were randomly divided into two groups with 25 subjects in each. Group I, consisted of subjects on which formocresol medicament was used after extirpation of coronal pulp while in Group II, 3% sodium hypochlorite was used. Clinical along with the radiographic signs and symptoms were blindly recorded at an interval of 1, 3, 6 and 12 months respectively. Results: Statistically significant results were obtained in group II, when patients treated with 3% sodium hypochlorite. There was no major difference between the two medicaments used, but to the various adverse effects of formocresol, its usage has been limited. Conclusion: within the limitation of the study, it was concluded that sodium hypochlorite medicament proved to have better prognosis and can be suggested as a pulpotomy agent for primary teeth. Although formocresol was found to have similar significant results can also be used as a medicament. Keywords: Formocresol, Pulpotomy, Primary Teeth, Sodium Hypochlorite

APA, Harvard, Vancouver, ISO, and other styles

36

Aksionov, Viktor. "Reflection of the family structure of the population at the biritual burial ground of the Saltiv culture in Chervona Hirka." Arheologia, no. 4 (December 10, 2021): 49–65. http://dx.doi.org/10.15407/arheologia2021.04.049.

Full text

Abstract:

The article presents the preliminary results of the analysis of individual burial complexes discovered at the biritual burial ground of the Saltiv culture in Chervona Hirka (Balakliia district of Kharkiv Oblast). During the work at the burial ground, 313 burials were examined, of which 191 were performed as inhumations, and 122 – cremations. Also, 18 cases were recorded at the burial ground when some burials were inlet into the filling of the burial pits of other burials without destroying the latter. At the same time, most often, the main burial was an inhumation according to the rite, and the burial inlet into the filling of the burial pit belonged to the category of cremations (Table 1). Among the complexes under consideration, the burials performed simultaneously (one-act) and those made after a certain period of time are presented. The latter are numerically dominant over one-act burial complexes. In 18 cases, 11 burials belong to paired ones, in 6 cases a burial contained the remains of three deceased. In the filling of burial No. 75/ k-4, the remains of three deceased were found, deliberately placed there. Thus, in Chervona Hirka burial ground, cases are presented of one burial pit usage for the simultaneous or different graves of 2—4 deceased. In these complexes, we tend to see the burials of close relatives, members of the same family (husband and wife, mother with children, minor children). An analysis of the sex and age composition of people buried in these complex burials allows us to speak of the existence of undivided families of the paternal or fraternal type among the population who left the Chervona Hirka burial ground, along with small families. The most striking evidence of the latter is the fixation of a group of 11 burials (6 inhumations and 5 cremations) on an area of 25 m2, the main one is the burial of a man accompanied by a horse (burial No. 75/ k-4) (Fig. 6: 1). At the same time, in the filling of three graves from this group (No. 75/ k-4, No. 36 and No. 74) there were burial complexes, deliberately placed there: Nos. 37, 38, 58, 59, 64, 71 (Table 1).

APA, Harvard, Vancouver, ISO, and other styles

37

Kamaev, A. V., Yu L. Mizernitsky, O. V. Trusova, I. A. Kamaeva, and N. L. Shaporova. "Dependence of thymic stromal lymphopoietin serum concentration from bronchial asthma control level and lung function results in patients of different age groups." Meditsinskiy sovet = Medical Council, no. 1 (March 6, 2022): 319–26. http://dx.doi.org/10.21518/2079-701x-2022-16-1-319-326.

Full text

Abstract:

Introduction. Bronchial asthma (BA) pathogenesis is settled by bronchial wall inflammation, which is the main treatment target.Aim. To study the dependence of thymic stromal lymphopoietin (TSLP) concentration in serum and nasal brush-biopsies from age, spirometry data deterioration and blood eosinophils in patients with uncontrolled BA.Materials and methods. Patients with uncontrolled BA of three age groups: children (6–11 y.o., n = 38), adolescents (14–17 y.o., n = 35) and adults (25–50 y.o., n = 31) were included in 1-year long open prospective study. Clinical history, АСТ/сАСТ questionnaires, lung function test (LFT), common blood count, serum and nasal material to evaluate TSLP were obtained during first visit, if there were no any signs of acute respiratory infection for not less than 14 days. Maintenance therapy was revised based on firstvisit findings. Patient were consequently examined twice with 6 months intervals, examination data, LFT readings, ACT results and eosinophil counts were collected. Statistical analyses included ANOVA (Kruskal-Wallis test) and Pearson’s correlation (r). Differences accepted significant with р < 0,05.Results. Serum TSLP levels did not differ between age groups. TSLP concentration correlate directly and significantly with duration of uncontrolled BA in previous 12 months (r = 0.74). In patients with atopic BA, maximum TSLP level was in dust mites sensitized group (792.6 ± 114.1 pg/ml). We have found greater serum TSLP concentration in patients who demonstrated FEV1 below normal even on optimal controller therapy at Visit 3. Eosinophil count randomly changed inside normal values and did not correlate with asthma control or TSLP level.Conclusion. Prognosis of future asthma exacerbations and LFT decrease is less favourable in patients with high serum TSLP level.

APA, Harvard, Vancouver, ISO, and other styles

38

Ghaffar, Naeem, Nadia Farooq, and Muhammad Shahid Hussain. "Limberg Flap Versus Open Procedure in Treatment of Chronic Pilonidal Sinus." Pakistan Journal of Medical and Health Sciences 16, no. 3 (2022): 248–49. http://dx.doi.org/10.53350/pjmhs22163248.

Full text

Abstract:

Objective: The main purpose of the study is to compare the outcomes of Limberg flap and open procedure to treat the chronic pilonidal sinus. Pilonidal sinus is a disorder of the sacrococcygeal region mostly found in younger folk. Its treatment consists of several methods but in this study, we will go through Limberg flap and open procedure to compare the outcomes of both methods. Study design: Comparative study. Material & Methods: This study was conducted from January 2020 to December 2022. 84 patients included 59 males and 25 females having age between 18 to 40 years were part of the study. All the selected patients were diagnosed with chronic pilonidal sinus and recommended for surgery at sugery Unit1 sir ganga ram hospital Lahore, Pakistan. A total of 84 patients were divided into two groups, group1 consists of 42 patients treated for the Limberg flap technique. Group 2 also contains 42 patients treated for an open procedure. The patients who were suffering from the chronic pilonidal sinus were part of the study while patients who had acute inflammation of the sinus, history of previous treatment of pilonidal sinus were omitted from the study. Results: Out of 84 patients 42 were part of group 1 and the remaining 42 were in group 2. In group1, the mean ±SD age of patients was 26 ± 2.00, 30 (71.4%) males and 12 (28.5%) females. While in group2 the mean ±SD age was 25 ± 3.00, 29 (69%) were males and 13 (30.9%) females were part of this group. The measured p-value for both groups was <0.05. General characteristics of patients show that high percentage of males was affected from pilonidal sinus disease. In group1 patients who had a 2 days stay at the hospital, recurrence was reported in 10 (23.8%) patients with P-value >0.05, irregular scar formation was observed in 16 (38%) patients, the pain was reported in 18 (42.8%) patients, and wound healing after 2 weeks was noted in 20 (47%) patients. In group 2, patients had 6 days stay at the hospital, recurrence was reported in 13 (30.9%) patients with value >0.05, irregular scar formation was observed in 26 (61%) patients, the pain was reported in 34 (80%) patients and wound healing after 2 weeks was noted in 12 (28.57%) patients. p-value was measured <0.05 for all the parameters. Conclusion: Eventually, we concluded significant results of the Limberg flap than the open procedure. A high percentage of complications were measured in patients treated with the open procedure in comparison to the Limberg flap. Keywords: Chronic pilonidal sinus, Limberg flap, open procedure.

APA, Harvard, Vancouver, ISO, and other styles

39

Li, Shaoliang. "Wound and Sural Nerve Complications of the Sinus Tarsi Approach for Calcaneus Fractures." Foot & Ankle International 39, no. 9 (2018): 1106–12. http://dx.doi.org/10.1177/1071100718774808.

Full text

Abstract:

Background The purpose of this study was to evaluate the optimal timing and measures of the sinus tarsi approach for calcaneus fractures to avoid iatrogenic injury of the sural nerve and to assess for wound complications. Methods: A case series of 53 patients with calcaneus fractures treated by a single surgeon with the sinus tarsi approach was retrospectively analyzed. On the basis of the delay time from injury to surgery, patients were classified into 4 groups: immediate (0–3 days), early (4–6 days), intermediate (7–14 days), and late (14–18 days). All patients were followed for at least 1 year to observe wound conditions. The rate of wound complications and iatrogenic sural nerve injury was described. Incisions were classified into 2 groups: group A included patients with incisions extending posterior to the lateral malleolus, and group B included patients with incisions confined anterior to the lateral malleolus. The rates of nerve injury were compared between both groups. Forty-three patients with 52 Sanders type II fractures were included. Results: The average time to surgery from injury was 8.8 days (range, 0–18 days). The overall postoperative rate of wound complications was 5.8% (3 of 52). In the immediate group, deep infections and wound necrosis were found in 2 of 8 fractures (25%). In the early group, 1 of 15 fractures developed superficial infection (6.7%). In the intermediate and late groups, no wound complication was identified. Iatrogenic sural nerve injury was recorded in 5 of 52 patients (9.6%). Group A had 33% (4 of 12) nerve injuries and group B had 2.5% (1 of 40) ( P = .009). In 70% of cases, a main branch of the sural nerve was directly under the incision. Conclusions: The sinus tarsi approach was generally effective and safe for calcaneus fractures. However, it was relatively risky to perform open reduction and internal fixation by the sinus tarsi approach within 6 days of injury. Because the sural nerve is in the vicinity of the approach, iatrogenic injury should be avoided by the use of careful planning and meticulous manipulations. Level of Evidence Therapeutic; Level III, comparative study.

APA, Harvard, Vancouver, ISO, and other styles

40

Schmidl, Doreen, Nikolaus Hommer, and Anton Hommer. "An Exploratory Retrospective Data Analysis Comparing the Outcomes of Selective Laser Trabeculoplasty and Argon Laser Trabeculoplasty in Patients with Open-Angle Glaucoma or Ocular Hypertension in Vienna, Austria, from the Year 2012 to 2022." Medicina 59, no. 12 (2023): 2075. http://dx.doi.org/10.3390/medicina59122075.

Full text

Abstract:

Background and Objectives: The aim of the present study was to compare the short-term outcomes of selective laser trabeculoplasty (SLT) with argon laser trabeculoplasty (ALT) in patients with glaucoma in a real-world setting. Materials and Methods: The present study was conducted as a retrospective case–control study. The main outcome was the change in intraocular pressure (IOP) three months after laser surgery. In addition, the number of substances used for lowering of IOP and adverse events (AEs) were assessed. Results: Charts from 25 patients were included in the present study, of which 12 had received ALT and 13 SLT. In both groups, IOP significantly decreased from baseline values 6 weeks and 3 months after laser treatment (p < 0.01 vs. baseline at each timepoint for both groups). While after 6 weeks, no difference between groups was found, after 3 months, the decrease in IOP was significantly more pronounced in the SLT group (−26 ± 21% in the ALT group vs. −41 ± 14% in the SLT group, p = 0.018 between groups, ANOVA). Three months after laser treatment, the number of IOP-lowering substances used by each patient had decreased with no difference between groups (ALT: from 2.7 ± 0.8 to 2.3 ± 0.9 substances; SLT: from 1.8 ± 1.2 to 1.3 ± 1.1 substances, p = 0.386). Only a few AEs were observed. Two patients in the ALT and one patient in the SLT group required trabeculectomy within 1 year after laser treatment due to IOP decompensation. Conclusions: In the present study, SLT was at least as effective as ALT with fewer AEs and a similar reduction in concomitant IOP-lowering medication.

APA, Harvard, Vancouver, ISO, and other styles

41

Кошулько, П. А., А. В. Думачев, В. В. Кочерыжко та ін. "Витамин D и менструальный цикл у пациенток репродуктивного возраста". Репродуктивное здоровье. Восточная Европа 15, № 2 (2025): 177–82. https://doi.org/10.34883/pi.2025.15.2.004.

Full text

Abstract:

Цель. Оценить связь между уровнем витамина D и менструальным циклом женщин репродуктивного возраста. Материалы и методы. В исследовании приняли участие 98 пациенток с нарушениями менструальной функции (основная группа) и 112 здоровых пациенток с физиологическим менструальным циклом (контрольная группа) в возрасте от 18 до 45 лет. Критерии оценки целевых значений уровня витамина D (25-ОН D) в крови были следующими: выраженный дефицит витамина D – <10 нг/мл, дефицит витамина D – <20 нг/мл, недостаточность витамина D – 20–30 нг/мл, адекватные уровни витамина D – 30– 100 нг/мл, уровни с возможным проявлением токсичности витамина D – >150 нг/мл. Критериями оценки физиологичности менструации являлись длительность менструации, продолжительность менструального цикла, регулярность менструаций, объем кровопотери, наличие или отсутствие менструальной боли. Количество витамина D в сыворотке крови определяли с помощью набора RECIPE HPLC Complete Kit и Shimadzu SPD-40 для высокоэффективной жидкостной хроматографии (ВЭЖХ). Результаты. При анализе показателей витамина D в сыворотке крови у исследуемых пациенток были выявлены статистически значимые различия между основной и контрольной группами. Так, выраженный дефицит витамина D имели 10 пациенток в основной и 1 пациентка в контрольной группе, дефицит витамина D был у 59 пациенток в основной и 1 пациентки в контрольной группе, недостаточность витамина D была зарегистрирована у 16 пациенток в основной и 3 пациенток в контрольной группе, а адекватные уровни витамина D – у 13 пациенток в основной и 107 пациенток в контрольной группе. При анализе нарушений менструальной функции было выяснено, что вторичной аменореей страдали 1 пациентка с выраженным дефицитом витамина D, 4 пациентки с дефицитом витамина D, 2 пациентки с недостаточностью витамина D, 8 пациенток с адекватными уровнями витамина D; альгодисменореей страдали 3 пациентки с выраженным дефицитом витамина D, 15 пациенток с дефицитом витамина D, 5 пациенток с недостаточностью витамина D, 4 пациентки с адекватными уровнями витамина D; аномальными маточными кровотечениями страдали 6 пациенток с выраженным дефицитом витамина D, 4 пациентки с дефицитом витамина D, 9 пациенток с недостаточностью витамина D, 1 пациентка с адекватными уровнями витамина D. Заключение. На основании полученных данных можно сделать вывод, что уровень витамина D в сыворотке крови влияет на менструальный цикл женщин репродуктивного возраста. Данная тема требует дальнейшего исследования и изучения. Purpose. Evaluate the relationship between vitamin D levels and the menstrual cycle in women of reproductive age. Materials and methods. The study included 98 patients with menstrual dysfunction (main group) and 112 healthy patients with a physiological menstrual cycle (control group) aged 18 to 45 years. The criteria for assessing target levels of vitamin D (25-OH D) in the blood were as follows: severe vitamin D deficiency – <10 ng/mL, vitamin D deficiency – <20 ng/mL, vitamin D insufficiency – 20–30 ng/mL, adequate vitamin D levels – 30–100 ng/mL, and levels with possible vitamin D toxicity – >150 ng/mL. The criteria for assessing the physiological nature of menstruation included menstrual duration, menstrual cycle length, regularity, blood loss volume, and the presence or absence of menstrual pain. The amount of vitamin D in serum was determined using the RECIPE HPLC Complete Kit and Shimadzu SPD-40 for HPLC (high-performance liquid chromatography). Results. The analysis of vitamin D levels in the serum of the patients studied revealed statistically significant differences between the main and control groups. Severe vitamin D deficiency was observed in 10 patients in the main group and 1 patient in the control group. Vitamin D deficiency was found in 59 patients in the main group and 1 patient in the control group. Vitamin D insufficiency was recorded in 16 patients in the main group and 3 patients in the control group, while adequate vitamin D levels were present in 13 patients in the main group and 107 patients in the control group. When analyzing menstrual dysfunction, it was found that secondary amenorrhea was present in 1 patient with severe vitamin D deficiency, 4 patients with vitamin D deficiency, 2 patients with vitamin D insufficiency, and 8 patients with adequate vitamin D levels. Dysmenorrhea was observed in 3 patients with severe vitamin D deficiency, 15 patients with vitamin D deficiency, 5 patients with vitamin D insufficiency, and 4 patients with adequate vitamin D levels. Abnormal uterine bleeding was noted in 6 patients with severe vitamin D deficiency, 40 patients with vitamin D deficiency, 9 patients with vitamin D insufficiency, and 1 patient with adequate vitamin D levels. Conclusion. Based on the obtained data, it can be concluded that the level of vitamin D in serum affects the menstrual cycle of women of reproductive age. This topic requires further research and investigation.

APA, Harvard, Vancouver, ISO, and other styles

42

G, Raghu. "Sonological evaluation of thyroid swellings." MedPulse International Journal of Radiology 12, no. 2 (2021): 72–76. http://dx.doi.org/10.26611/10131225.

Full text

Abstract:

Background: Ultrasonography has become the procedure of choice for the initial evaluation of thyroid gland in many centers. It permits a quick evaluation of thyroid gland; its relationship with adjacent structure and an assessment of the main lymph node chains of the neck. The major advantage of ultrasound is the rapidity with which the images are obtained. In order to study the various typical and atypical sonological features of those lesions presenting as thyroid swellings, this study was undertaken. Aims and Objectives: To evaluate thyroid swelling with reference to-Ultrasonic appearance and characteristics of thyroid gland in its various disorders. Materials and Methods: In this series, during the period from September 2002 to September 2004, 65 cases of clinically suspected thyroid swellings were studied using real time ultrasound. The patients were referred from surgical and medical units of Victoria hospital, Bangalore. Results: 16.92% of patients were males and 83.08% females with male to female ratio of 1:4.9. Maximum number of cases was found in the age group 31-40 years (25 out of 65 cases i.e. 38.46%). Nodular goiter was found in 56.91% and 5 patients of thyroid malignancy of which 3 patients were papillary carcinoma, 1 was follicular carcinoma, and 1 patient was anaplastic carcinoma. The sonographic findings in clinical diagnosis of solitary thyroid nodule in 38 patients only 22 (i.e. 57.89%) of these were truly solitary on ultrasound examination. Of 27 patients referred with clinical diagnosis of multinodular disease, 6 patients had diffuse enlargement of the gland, 20 patients had multinodular involvement on ultrasonographic examination. Conclusions: Thyroid lesions were more common in females with male to female ratio of 1:4.9. Most frequently encountered thyroid lesion was nodular goiter and maximum incidence occurred in the age group of 31-40 years. 11 cases of adenoma and 5 cases of thyroid malignancy were found which included 3 cases of papillary carcinoma suggesting it as the commonest malignancy.

APA, Harvard, Vancouver, ISO, and other styles

43

G, Raghu. "Sonological evaluation of thyroid swellings." MedPulse International Journal of Radiology 12, no. 2 (2021): 72–76. http://dx.doi.org/10.26611/10131225.

Full text

Abstract:

Background: Ultrasonography has become the procedure of choice for the initial evaluation of thyroid gland in many centers. It permits a quick evaluation of thyroid gland; its relationship with adjacent structure and an assessment of the main lymph node chains of the neck. The major advantage of ultrasound is the rapidity with which the images are obtained. In order to study the various typical and atypical sonological features of those lesions presenting as thyroid swellings, this study was undertaken. Aims and Objectives: To evaluate thyroid swelling with reference to-Ultrasonic appearance and characteristics of thyroid gland in its various disorders. Materials and Methods: In this series, during the period from September 2002 to September 2004, 65 cases of clinically suspected thyroid swellings were studied using real time ultrasound. The patients were referred from surgical and medical units of Victoria hospital, Bangalore. Results: 16.92% of patients were males and 83.08% females with male to female ratio of 1:4.9. Maximum number of cases was found in the age group 31-40 years (25 out of 65 cases i.e. 38.46%). Nodular goiter was found in 56.91% and 5 patients of thyroid malignancy of which 3 patients were papillary carcinoma, 1 was follicular carcinoma, and 1 patient was anaplastic carcinoma. The sonographic findings in clinical diagnosis of solitary thyroid nodule in 38 patients only 22 (i.e. 57.89%) of these were truly solitary on ultrasound examination. Of 27 patients referred with clinical diagnosis of multinodular disease, 6 patients had diffuse enlargement of the gland, 20 patients had multinodular involvement on ultrasonographic examination. Conclusions: Thyroid lesions were more common in females with male to female ratio of 1:4.9. Most frequently encountered thyroid lesion was nodular goiter and maximum incidence occurred in the age group of 31-40 years. 11 cases of adenoma and 5 cases of thyroid malignancy were found which included 3 cases of papillary carcinoma suggesting it as the commonest malignancy.

APA, Harvard, Vancouver, ISO, and other styles

44

Nawasreh, Zakariya, David Logerstedt, Kathleen Cummer, Michael J. Axe, May Arna Risberg, and Lynn Snyder-Mackler. "Do Patients Failing Return-to-Activity Criteria at 6 Months After Anterior Cruciate Ligament Reconstruction Continue Demonstrating Deficits at 2 Years?" American Journal of Sports Medicine 45, no. 5 (2016): 1037–48. http://dx.doi.org/10.1177/0363546516680619.

Full text

Abstract:

Background: The variability in outcomes after anterior cruciate ligament reconstruction (ACLR) might be related to the criteria that are used to determine athletes’ readiness to return to their preinjury activity level. A battery of return-to-activity criteria (RTAC) that emphasize normal knee function and movement symmetry has been instituted to quantitatively determine athletes’ readiness to return to preinjury activities. Purpose: To investigate performance-based and patient-reported measures at 12 and 24 months after ACLR between patients who passed or failed RTAC at 6 months after ACLR. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 108 patients who had participated in International Knee Documentation Committee level 1 or 2 sports activities completed RTAC testing at 6, 12, and 24 months after surgery. The RTAC included the isometric quadriceps strength index (QI), 4 single-legged hop tests, the Knee Outcome Survey–activities of daily living subscale (KOS-ADLS), and the global rating scale of perceived function (GRS). Patients who scored ≥90% on all RTAC were classified as the pass group, and those who scored <90% on any RTAC were classified as the fail group. At 12- and 24-month follow-ups, patients were asked if they had returned to the same preinjury activity level. Results: At the 6-month follow-up, there were 48 patients in the pass group and 47 in the fail group. At the 12-month follow-up, 31 patients (73.8%) from the pass group and 15 patients (39.5%) from the fail group passed RTAC, and at the 24-month follow-up, 25 patients (75.8%) from the pass group and 14 patients (51.9%) from the fail group passed RTAC. The rate of return to activities in the pass group was 81% and 84% at 12 and 24 months after ACLR, respectively, compared with only 44% and 46% in the fail group ( P ≤ .012), respectively; however, some patients in the fail group participated in preinjury activities without being cleared by their therapists. At 12 and 24 months, 60.5% and 48.1% of patients continued to fail again on the criteria, respectively. A statistically significant group × time interaction was found for the single hop and 6-m timed hop limb symmetry indices (LSIs) ( P ≤ .037), with only the fail group demonstrating a significant improvement over time. A main effect of group was detected for the QI and the crossover hop and triple hop LSIs ( P < .01), with patients in the pass group demonstrating higher performance. A main effect of time was detected for the crossover hop and triple hop LSIs and the GRS, with improvements seen in both groups ( P < .05). Conclusion: Patients who passed the RTAC early after ACLR were more likely to demonstrate normal knee function and movement symmetry at 12 and 24 months postoperatively, while patients who failed the RTAC early were more likely to demonstrate impaired knee function and movement asymmetry at 12- and 24-month follow-ups. Patients in the pass group had a higher rate of return to their preinjury activity level compared with those in the fail group. A group of patients chose to return to their preinjury activities, even though they were functionally not ready.

APA, Harvard, Vancouver, ISO, and other styles

45

Miroshnichenko, A. S., V. G. Klochkova, E. L. Chentsov, V. E. Panchuk, M. V. Yushkin, and N. Manset. "First high-resolution optical spectra of the distant emission-line star VES 723 (IRAS 02110+6212)." Monthly Notices of the Royal Astronomical Society 507, no. 1 (2021): 879–85. http://dx.doi.org/10.1093/mnras/stab2193.

Full text

Abstract:

ABSTRACT The first high-resolution spectra (resolving powers of R ≥ 60 000) of the emission-line star VES 723, which has an unknown evolutionary status, were taken at the 6-m Big Telescope Alt-Azimuthal and the 3.6-m Canada–France–Hawaii Telescope. The spectrum is dominated with powerful emission lines of neutral hydrogen and helium, and forbidden singly ionized nitrogen. The Hα and He i lines were found to exhibit broad foundations of the emission profiles at least 250 km s−1 wide. The strongest emission lines exhibit no noticeable variations during the observing period (2011–2017) except for the He i lines. The spectra contain multicomponent interstellar absorptions of Na i and K i (mult. 1) and several strongest diffuse interstellar bands, while photospheric absorptions have not been detected. The average radial velocity of the forbidden [N ii] emission line centres was adopted as the systemic velocity (Vsys ≈ −52 km s−1), which indicates a large distance of ≈6 kpc. Our luminosity estimates of log L/L⊙ = 3.7−4.0 for two different Gaia distance measurements, along with an effective temperature of Teff = 25 000 ± 2000 K and a fast decrease of the infrared flux longward of $\lambda \sim 10\, \mu{\rm m}$, allow us to suggest that VES 723 is neither a pre-main-sequence Herbig B[e] star nor a B[e] supergiant but rather a member of the FS CMa group of objects with the B[e] phenomenon.

APA, Harvard, Vancouver, ISO, and other styles

46

Wang, Baiyan, Jie Liu, Wan-Hong Zhao, et al. "Chimeric Antigen Receptor T Cell Therapy in the Relapsed or Refractory Multiple Myeloma with Extramedullary Disease--a Single Institution Observation in China." Blood 136, Supplement 1 (2020): 6. http://dx.doi.org/10.1182/blood-2020-140243.

Full text

Abstract:

Background: Extramedullary disease (EMD) is characterized as the presence of myeloma cells invasion outside the bone marrow in a patient with multiple myeloma (MM), it may be found 6%~8% in de novo patients, and 10% to 30% in relapsed or refractory (R/R) MM patients across the overall disease course (Joan Blade et al. 2011, Matthew Weinstock et al. 2013 and 2015, Cyrille Touzeau et al. 2015). EMD was considered as high-risk group of myeloma and is associated with adverse prognosis and the management is particularly challenging. Here we discuss and improve the understanding of the clinical characters and prognoses of the R/R MM with EMD in the treatment of CAR T therapy, illustrate our experience in a single institution. Methods: LCAR-B38M is a Chimeric antigen receptor (CAR) T cell therapy with 4-1BB as the co-stimulator, a dual epitope-binding CAR T cell therapy directed against 2 distinct B cell maturation antigen (BCMA) epitopes. In total of 57 patients were treated in China from The Second Affiliated Hospital of Xi'an Jiaotong University (LEGEND-2, NCT03090659), 17 patients with R/R MM with EMD were included and received the CAR T treatment. The study was initiated on March 30, 2016, and the analysis reported here is from a data cutoff date of July 31, 2019, the detailed treatment schema was presented in the former paper (Zhao et al, 2018). Results: Overall, 17 (29.8%) of 57 treated patients with EMD were included in our CAR T treatment. The median age of R/R MM patients with EMD (EMD group) and without EMD (non-EMD group) were 55 (range, 27-72) and 53.3 (range, 42-73) years old respectively, and the median number of prior therapy lines were 3 (range, 1-6 and 1-9) in both groups. There were no statistical difference in the proportion of male and female patients, median time from initial diagnosis and ISS stage in EMD group and non-EMD group. The Eastern Cooperative Oncology Group (ECOG) scores of patients receiving CAR T treatment were 0-2 points, the proportion of ECOG 1-2 points in EMD group were higher than non-EMD group (P &lt; 0.05, R=0.1474, 95% CI, 0.03 to 0.73). IgG and IgA subtype were the main types in the non-EMD patients while the light chain type was more frequently seen in EMD group (P = 0.014, OR=0.1886, 95% CI, 0.05 to 0.66). The overall response rates (ORR) in the EMD group and non-EMM group were 82.4% and 90% respectively (Fig 1 A), and there were no significant difference in the median time to the first response and the best response between the EMD group and non-EMD group(P &gt; 0.05). At cutoff, the median follow-up was 25 months, the median progression-free survival (PFS) in EMD group and non-EMD group were 8.1 months and 25 months (P &lt; 0.001, R=0.32, 95% CI, -0.19 to 0.84), and the median overall survival (OS) were 13.9 months and not reached (P = 0.0019, R=4.833, 95% CI, 1.91 to 12.22), survival curves were shown in Fig 1 B, C . Conclusions: LCAR-B38M is a highly effective therapy in R/R MM patients with EMD and without EMD, and both groups had similar response time and reached a high ORR rate. R/R MM patients with EMD demonstrated a poor prognosis and they may lost their best response in a relatively shorter time compared with the patients without EMD. With a median follow-up of 25 months, LCARB38M manifested a relatively durable therapeutic effect in this high-risk R/R MM patients with EMD. Disclosures No relevant conflicts of interest to declare.

APA, Harvard, Vancouver, ISO, and other styles

47

Türeyen, Kudret. "One-level one-sided lumbar disc surgery with and without microscopic assistance: 1-year outcome in 114 consecutive patients." Journal of Neurosurgery: Spine 99, no. 3 (2003): 247–50. http://dx.doi.org/10.3171/spi.2003.99.3.0247.

Full text

Abstract:

Object. The aim of this study was to compare the outcomes following macrodiscectomy and microsurgery for one-level one-sided lumbar disc excision. Methods. The authors prospectively studied 114 consecutive patients who underwent microdiscectomy (Group A, 63 patients [36 men, 27 women]) and macrodiscectomy (Group B, 51 patients [29 men, 22 women]) for one-level unilateral first-time lumbar disc herniation. Microdiscectomy was considered to involve a small incision with removal or opening of the ligamentum flavum, no or minimal bone excision, and use of the operating microscope to remove the disc material. Laminectomy combined with macrodiscectomy was defined as any operation requiring a large opening in or complete removal of the unilateral lamina. Diagnosis was confirmed by magnetic resonance imaging. A 1-year follow-up investigation was also conducted. Relief of radicular pain, improvement in muscle power, and changes in sensory and/or reflex abnormality were documented. Assessment of outcome was performed using the modified Stauffer—Coventry criteria. Good or excellent results were demonstrated in 90% of Group A and 89% of Group B patients (p > 0.05). One patient in each group underwent reoperation. There was infection over the fascia in two Group A patients. Mean operative time (± standard deviation) was 54 ± 5.65 minutes in Group A and 25 ± 7.07 minutes in Group B (p < 0.01). Median length of the incision was 4 and 6 cm in Group A and Group B, respectively (p < 0.05). The length of postoperative inpatient stay was 1 day in both groups (p > 0.05). Patients in the microsurgery-treated group returned to work in less time: 85% of Group A and 58% of Group B patients returned to their work within 4 weeks (p < 0.001). Some patients in each group (15% in Group A and 45% in Group B) needed narcotic analgesic medication at least twice between the 1st month and 1st year after the surgery (p < 0.001). Conclusions. Microdiscectomy allows the surgeon good visualization and is less traumatic to the involved tissues. Interestingly, the results of this study indicated that microsurgery does not reduce hospitalization time, nor does it improve the overall surgery-related outcome. The main differences between the two procedures were length of the incision and operative time. The author found that lumbar microdiscectomy allows patients earlier return to work and/or normal life with less reliance on postoperative narcotic analgesic agents.

APA, Harvard, Vancouver, ISO, and other styles

48

Kerestei, Vadym, Oleksandr Z. viriaka, Yuliya Kalmykova, Viktoriia Polkovnyk-Markova, and Olha Lianna. "Physical therapy of persons after acute cerebrovascular accident in a long-term rehabilitation period." Physical rehabilitation and recreational health technologies 9, no. 4 (2024): 327–42. http://dx.doi.org/10.15391/prrht.2024-9(4).11.

Full text

Abstract:

Purpose: to study the dynamics of recovery of walking, balance and quality of life of persons after acute cerebrovascular accident in a long-term rehabilitation period. Material and methods: patients were randomly divided into a main group (MG), which included 35 patients (n=35), and a comparison group (CG), which included 38 patients (n=38). The groups received rehabilitation intervention in accordance with the concept of the International Classification of Functioning, Disability, and Health (ICF). A categorical profile was created for each person and SMART goals were set. A physical therapy (PT) program was developed for MG after acute cerebrovascular accident (ACVA) in the long-term rehabilitation period. Short- and long-term goals were set in the SMART format, which included the use of therapeutic exercises. Functional capabilities and quality of life were assessed before and after the rehabilitation intervention using the ten-meter walk test, the Tinetty balance and fall risk scale, the modified Renkin functional independence scale and quality of life. Results: the dynamics of the ten-meter walking test during the PT program among patients in the MG is reflected in a decrease in the test completion time, which amounted to 23,6 s, and in the CG – 7 s. By the time of the final examination, the range of the obtained values was limited to 8 and 15 s in the MG, and among the CG, the extreme values were found at the levels of 12 and 160 s. By the time of the final examination, the "balance" item on the Tinetty balance and risk of falls scale in the MG was 13,8 ± 1,69 points out of a possible 16 points; the Me (25%; 75%) indicators were 14 (13; 15) points. In the CG, the indicator was slightly lower and was 12,3 ± 2,61 points; the Me (25%; 75%) indicators were 13 (10; 15) points. The difference between the groups by the end of the study for this indicator was significant (p<0.05). As for the increase, it was 4.7 points in the MG and 3.1 points in the CG. The average statistical results of the assessment of the “Risk of Falls” section in the MG were 9.2±1.59 points out of a possible 12; the Me (25%; 75%) indicators were 9 (8; 11) points. In the CG patients, the indicator was slightly lower and was 5,2±1,99 points; the Me (25%; 75%) indicators were 6 (4; 6.3) points. The difference between the groups by the end of the study for this indicator was significant. (р<0,01). As for the increase, it was 5 points in MG and 1,4 points in CG. The intermediate results on the Renkin scale were 1,83±0,62 and 2,13±0,74 points in MG and CG with Me (25%; 75%) – 2 (2; 2) and 2 (2; 3), respectively. At this stage, there was no statistical difference between the groups (p>0,05), but both groups showed a reliable improvement compared to the initial result (p<0,01). During the final examination, the results in MG patients improved and were 1,11±0,62 points, where the Me (25%; 75%) indicators were found at the level of 1 (1; 2) point. Among the CG patients, the final result was worse (p<0.01) and was found at the level of 1,55±0,72 points with Me (25%; 75%) 1 (1; 2) point. Conclusions: Analysis of the dynamics of walking, balance and quality of life indicators after acute cerebrovascular accident in a long-term rehabilitation period confirmed the advantages of the developed physical therapy program for individuals from the MG.

APA, Harvard, Vancouver, ISO, and other styles

49

Mekhtieva, N. I., L. N. Lyubchenko, A. D. Zikiryakhodzhaev, and M. V. Starkova. "Comparative analysis of the CYP2D6 metabolic activity and its effect on its effect on the treatment results of primary breast cancer." Bone and soft tissue sarcomas, tumors of the skin 13, no. 4 (2022): 39–47. http://dx.doi.org/10.17650/2782-3687-2021-13-4-39-47.

Full text

Abstract:

Background. Standard treatment for hormone receptor-positive breast cancer includes long-term hormone therapy. However, treatment efficacy varies even in homogeneous groups of patients. Tamoxifen is metabolized in the liver, resulting in the production of endoxifen, its active metabolite. Cytochromes P450 (CYP2D6, etc.) play a major role in converting tamoxifen to endoxifen. The CYP2D6 gene is extremely polymorphic and has more than 100 alleles that can encode normal, high, and low metabolic activity or be inactive. Thus, patients can be divided into three groups according to the presence or absence of CYP2D6 gene polymorphisms, namely slow, intermediate, and rapid metabolizers. Objective – to analyze the long-term results of complex treatment of patients with early breast cancer depending on the variability of the polymorphism of the CYP2D6 gene. Materials and methods. We analyzed the frequency of 3 main polymorphisms in the CYP2D6 gene among 89 patients with hormone receptor-positive stage I–II breast cancer who received tamoxifen at a dose of 20 mg/day as adjuvant hormone therapy for 6 months to 9 years. Homozygous carriers of wild-type CYP2D6 allele were assigned to the group of patients with unchanged (normal) metabolism (Group 1) (wt CYP2D6) (n = 64), whereas homozygous and heterozygous carriers of non-functional CYP2D6 alleles were included into the group of patients with slow metabolism (Group 2) (n = 25). Results. Disease progression was observed in 21 (23.6 %) patients with primary operable hormone receptor-positive breast cancer, including 10 women from Group 1 (15.6 %) and 11 women from Group 2 (44 %); the difference between them was statistically significant (p <0.05). Disease progression after combination therapy without chemotherapy was registered in 8 (22.9 %) patients, including 2 (5.8 %) patients with normal metabolism and 6 patients (17.1 %) with slow metabolism (р <0.05). Ten-year relapse-free survival rate was 85.9 % in Group 1 and 63.6 % in Group 2 (р = 0.02). We found no significant difference in overall survival rates between the two groups, which confirmed the results of other studies. Conclusion. The assessment of metabolic activity and its impact on the efficacy of combination treatment for breast cancer is a promising method; however, it requires further research in this area.

APA, Harvard, Vancouver, ISO, and other styles

50

De Waele, Marc, Barbara Leus, Fabienne Trullemans, et al. "Diagnostic Potential of Immunophenotyping CD34+ Cells in Myelodysplastic Syndromes." Blood 108, no. 11 (2006): 4836. http://dx.doi.org/10.1182/blood.v108.11.4836.4836.

Full text

Abstract:

Abstract Myelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal hematopoeitic stem cell disorders. They are characterized by abnormal bone marrow differentiation, peripheral blood cytopenia and a risk of transformation into acute myeloid leukemia (AML). The diagnosis of MDS depends on cytomorphology and cytogenetics and may be difficult especially in cases with normal numbers of blasts and without ringed sideroblasts in the bone marrow. Cytomorphology is subjective and dysplastic features may be present in other disorders than MDS. In this study we examined the potential of immunophenotyping CD34+ hematopoietic precursors for the diagnosis and classification of MDS. Bone marrow samples of 31 patients with low grade MDS (21 without and 10 with ringed sideroblasts), of 17 patients with refractory anemia with excess of blasts (RAEB), of 25 patients with AML and of 39 patients with cytopenia not due to MDS (controls) were examined. CD34+ cells were enumerated and the expression of B cell antigens (CD19), of myeloid antigens (CD13, CD33, CD117) and of immature antigens (CD133) was determined by flow cytometry. Statistical analysis was done with a Mann-Whitney test. A high number of CD34+ cells was found in MDS and AML. This was accompanied by an increase of the number of myeloid precursors and a decrease of the B cell precursors. CD117 appeared to be the best marker of myeloid precursors followed by CD13. A wide range of CD34+CD133+ and of CD34+CD33+ cells was found in all types of samples. Forty percent of the patients with low grade MDS showed an increased expression of CD117 on their CD34+ cells. In 25% of the cases without ringed sideroblasts a high expression of CD133 was present. Similar changes were more frequently found in RAEB and AML together with an increased expression of CD13 and CD33 and a low positivity for CD19. With a scoring system based on the expression of these antigens 57% of low grade MDS samples (score 1/6 or 2/6) could be distinguished from the controls (score 0/6). An elevated score was also found in respectively 84% and 100% of the RAEB and AML samples. 85% of them even had a score between 3/6 and 6/6. In conclusion, immunophenotyping of CD34+ cells is able to differentiate 60% of low grade MDS samples from other causes of cytopenia. Increased expression of CD117, CD133 and CD34 are the main differences. Similar changes are even more frequently found in RAEB and AML. A scoring system based on the antigen expression on the CD34+ cells is a powerful tool for the diagnosis and classification of MDS.

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'They were found in 25.6% in main group 1'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles