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Journal articles on the topic '] thiadiazine derivatives'

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Published: 4 June 2025

Last updated: 1 August 2025

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1

Innes, Dylan, Michael V. Perkins, Andris J. Liepa, and Craig L. Francis. "N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part XIV. Synthesis and Reactivity of the New Benzo[4,5]imidazo[1,2-b][1,2,6]thiadiazine Ring System." Australian Journal of Chemistry 71, no. 1 (2018): 58. http://dx.doi.org/10.1071/ch17255.

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N,N-Dialkyl-N′-chlorosulfonyl chloroformamidines 1 underwent regioselective reactions with the 1,3-NCC bis-nucleophilic 1H-benzimidazole-2-acetonitriles 4 and related compounds to produce benzo[4,5]imidazo[1,2-b][1,2,6]thiadiazine dioxides 6, 9, 12, and 14, representatives of a new ring system. Reaction of dichlorides 1 with trifluoroacetyl derivative 16 afforded benzo[4,5]imidazo[1,2-c]pyrimidines 19 and 20. An N-acyl and some N-alkyl derivatives of benzimidazo-thiadiazines 6 were prepared to demonstrate the potential of this new ring system as a novel scaffold for synthetic and medicinal che

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2

Mostafa, Mohamed S., Ibrahim Ali M. Radini, Naglaa M. Abd El-Rahman, and Rizk E. Khidre. "Synthetic Methods and Pharmacological Potentials of Triazolothiadiazines: A Review." Molecules 29, no. 6 (2024): 1326. http://dx.doi.org/10.3390/molecules29061326.

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This review article examines the synthetic pathways for triazolothiadiazine derivatives, such as triazolo[3,4-b]thiadiazines, triazolo[5,1-b]thiadiazines, and triazolo[4,3-c]thiadiazines, originating from triazole derivatives, thiadiazine derivatives, or thiocarbohydrazide. The triazolothiadiazine derivatives exhibit several biological actions, including antibacterial, anticancer, antiviral, antiproliferative, analgesic, anti-inflammatory, and antioxidant properties. The review article aims to assist researchers in creating new biologically active compounds for designing target-oriented triazo

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3

Mlostoń, Grzegorz, Katarzyna Urbaniak, Malwina Sobiecka, et al. "Hetero-Diels-Alder Reactions of In Situ-Generated Azoalkenes with Thioketones; Experimental and Theoretical Studies." Molecules 26, no. 9 (2021): 2544. http://dx.doi.org/10.3390/molecules26092544.

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The hetero-Diels-Alder reactions of in situ-generated azoalkenes with thioketones were shown to offer a straightforward method for an efficient and regioselective synthesis of scarcely known N-substituted 1,3,4-thiadiazine derivatives. The scope of the method was fairly broad, allowing the use of a series of aryl-, ferrocenyl-, and alkyl-substituted thioketones. However, in the case of N-tosyl-substituted cycloadducts derived from 1-thioxo-2,2,4,4-tetramethylcyclobutan-3-one and the structurally analogous 1,3-dithione, a more complicated pathway was observed. By elimination of toluene sulfinic

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4

Yan, Jinghua, Weijie Si, Haoran Hu, Xu Zhao, Min Chen, and Xiaobin Wang. "Design, synthesis and antimicrobial activities of novel 1,3,5-thiadiazine-2-thione derivatives containing a 1,3,4-thiadiazole group." PeerJ 7 (September 6, 2019): e7581. http://dx.doi.org/10.7717/peerj.7581.

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A series of novel 1,3,5-thiadiazine-2-thione derivatives containing a 1,3,4-thiadiazole group was designed and synthesized. The structures of all the compounds were well characterized using 1H NMR, 13C NMR and high-resolution mass spectrometer, and further confirmed by the X-ray diffraction analysis of 8d. The antimicrobial activities of all the target compounds against Xanthomonas oryzae pv. oryzicola, X. oryzae pv. oryzae, Rhizoctonia solani and Fusarium graminearum were evaluated. The in vitro antimicrobial bioassays indicated that some title compounds exhibited noteworthy antimicrobial eff

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5

El-Sayed, Wael A., Omar M. Ali, Marwa M. Hathoot, and Adel A. H. Abdel-Rahman. "Synthesis and Antimicrobial Activity of New Substituted Fused 1,2,4-Triazole Derivatives." Zeitschrift für Naturforschung C 65, no. 1-2 (2010): 22–28. http://dx.doi.org/10.1515/znc-2010-1-204.

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A number of new substituted 1,2,4-triazole, 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole and 1,2,4-triazolo[3,4-b]1,3,4-thiadiazine derivatives were synthesized and tested for their antimicrobial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gramnegative), and Streptomyces species (Actinomycetes). The synthesized compounds displayed different degrees of antimicrobial activities or inhibitory actions.

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6

Gong, Tang, Liu та Liu. "Synthesis and Evaluation of Novel 2H-Benzo[e]-[1,2,4]thiadiazine 1,1-Dioxide Derivatives as PI3Kδ Inhibitors". Molecules 24, № 23 (2019): 4299. http://dx.doi.org/10.3390/molecules24234299.

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In previous work, we applied the rotation-limiting strategy and introduced a substituent at the 3-position of the pyrazolo [3,4-d]pyrimidin-4-amine as the affinity element to interact with the deeper hydrophobic pocket, discovered a series of novel quinazolinones as potent PI3Kδ inhibitors. Among them, the indole derivative 3 is one of the most selective PI3Kδ inhibitors and the 3,4-dimethoxyphenyl derivative 4 is a potent and selective dual PI3Kδ/γ inhibitor. In this study, we replaced the carbonyl group in the quinazolinone core with a sulfonyl group, designed a series of novel 2H-benzo[e][1

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7

Alsahib, Sanaa abdul. "Characterization and Biological Activity of Some New Derivatives Derived from Sulfamethoxazole Compound." Baghdad Science Journal 17, no. 2 (2020): 0471. http://dx.doi.org/10.21123/bsj.2020.17.2.0471.

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A new series of Sulfamethoxazole derivatives was prepared and examined for antifibrinolytic and antimicrobial activities. Sulfamethoxazole derivatives bear heterocyclic moieties such as 1,3,4-thiadiazine {3}, pyrazolidine-3,5-diol {4} 6-hydroxy-1,3,4-thiadiazinane-2-thione {5} and [(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)diazenyl] {8}. Their structures were elucidated by spectral methods (FT-IR, H1-NMR). Physical properties are also determined for all compound derivatives. Recently prepared compounds were tested for their antimicrobial activity in the laboratory. Each screened compound sho

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8

Abu-Hashem, Ameen Ali, and Rasha A. M. Faty. "Synthesis, Antimicrobial Evaluation of Some New 1, 3, 4-Thiadiazoles and 1, 3, 4- Thiadiazines." Current Organic Synthesis 15, no. 8 (2018): 1161–70. http://dx.doi.org/10.2174/1570179415666180720114547.

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Background: 1, 3, 4-thiadiazoles, 1, 3, 4-thiadiazines and thienopyrimidines have newly attracted attention due to their forceful pharmacological activities. They showed antimicrobial, antiviral, analgesic and anti-inflammatory properties. Objective: The aim of this research is to synthesize new thiadiazolothienopyrimidines (2-10), thienopyrimidothiadiazines (11-15), quinoxaline-thienopyrimidinones (16) and thienopyrimido- thiadiazinoquinoxalinones (17) via effectual high yield procedure for assessing their antimicrobial activity. Method: A series of new 1, 3, 4-thiadiazolothienopyrimidines, t

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9

Naqui, Jahan Siddiqui* Atul Barsagade Mohammad Idrees. "SYNTHESIS, ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF 1,3,5-THIADIAZINE DERIVATIVES." Indo American Journal of Pharmaceutical Sciences 04, no. 10 (2017): 3655–63. https://doi.org/10.5281/zenodo.1035798.

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A series of N-(4-(benzyloxy)benzylidene)-2-(arylimino)-6-(phenylimino)-3,6-dihydro-2H-1,3,5-thiadiazin-4- amine derivatives (4a-d) have been synthesized by condensation of 1-(N-4-(benzyloxy) benzylidenecarbamimidoyl)-3-arylthiourea (3a-d) with phenyl isocyanodichloride. Interaction of 1- carbamimidoyl-3-arylthiourea (2a-d) and p-benzyloxy benzaldehyde yielded (3a-d). Monoacetyl (5b) and mononitroso (6b) derivatives were also synthesised by substitution of hydrogen atom of cyclic –NH- of 4b on treatment with acetic anhydride and sodium nitrite respectively. Further, 4b upon boiling with 5% aque

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10

Obydennov, Konstantin L'vovich, Tatiana Andreevna Kalinina, Olga Alexandrovna Vysokova, et al. "The different modes of chiral [1,2,3]triazolo[5,1-b][1,3,4]thiadiazines: crystal packing, conformation investigation and cellular activity." Acta Crystallographica Section C Structural Chemistry 76, no. 8 (2020): 795–809. http://dx.doi.org/10.1107/s2053229620009328.

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The crystal structures of four new chiral [1,2,3]triazolo[5,1-b][1,3,4]thiadiazines are described, namely, ethyl 5′-benzoyl-5′H,7′H-spiro[cyclohexane-1,6′-[1,2,3]triazolo[5,1-b][1,3,4]thiadiazine]-3′-carboxylate, C19H22N4O3S, ethyl 5′-(4-methoxybenzoyl)-5′H,7′H-spiro[cyclohexane-1,6′-[1,2,3]triazolo[5,1-b][1,3,4]thiadiazine]-3′-carboxylate, C20H24N4O4S, ethyl 6,6-dimethyl-5-(4-methylbenzoyl)-6,7-dihydro-5H-[1,2,3]triazolo[5,1-b][1,3,4]thiadiazine-3-carboxylate, C17H20N4O3S, and ethyl 5-benzoyl-6-(4-methoxyphenyl)-6,7-dihydro-5H-[1,2,3]triazolo[5,1-b][1,3,4]thiadiazine-3-carboxylate, C21H20N4O4

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11

Nami, Navabeh, Fathali Gholami, Hooshang Vahedi, and Nasrin Nami. "Synthesis of Thiadiazine and Triazino[3,4-b]thiadiazine Derivatives." Phosphorus, Sulfur, and Silicon and the Related Elements 182, no. 9 (2007): 2157–62. http://dx.doi.org/10.1080/10426500701407474.

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12

Bibik, E. Yu, I. A. Nekrasa, A. V. Demenko, K. A. Frolov, V. V. Dotsenko, and S. G. Krivokolysko. "Studying the adaptogenic activity of a series of tetrahydropyrido[2,1-b] [1,3,5] thiadiazine derivatives." Bulletin of Siberian Medicine 18, no. 3 (2019): 21–28. http://dx.doi.org/10.20538/1682-0363-2019-3-21-28.

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Introduction. In the modern world people are exposed to the influence of adverse psychological and physical factors, escalating in intensity. The search for new pharmacodynamic effects of [1,3,5]-thiadiazine derivatives designated by significant biological activity of these compounds is an essential issue.Aim. To research adaptogenic activity of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives using a modified Porsolt Forced Swim Test.Materials and methods. Four substances from the group of 3-R-8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6Hpyrido[2,1-b][1,3,5]thiadiazine-9-carbonitriles were selec

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13

Norman, Rebecca E., Michael V. Perkins, Andris J. Liepa, and Craig L. Francis. "N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part XII. Synthesis and Reactivity of the Pyrazolo[3,4-e][1,2,4]thiadiazine Ring System." Australian Journal of Chemistry 68, no. 9 (2015): 1455. http://dx.doi.org/10.1071/ch15028.

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N,N-Dialkyl-N′-chlorosulfonyl chloroformamidines 1 reacted regioselectively with 1-substituted 5-aminopyrazoles 2 via a 1,3-CCN dinucleophilic substitution to afford pyrazolo[3,4-e][1,2,4]thiadiazines 3 as the sole isolated products. Compounds 3, representatives of a very rare ring system, were shown to possess three nucleophilic sites at N2, N4, and N6. Methylation occurred at all three sites. Alkylation with benzylic halides occurred preferentially at N2, but some also occurred at N4, and at C7a. Alkylation with ethyl bromoacetate occurred at both N4 and N6, but the latter derivatives underw

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14

Amer, A. A., O. A. Omran, and A. Khodairy. "Utility of Hydrazinopiperidinomethanethione in Synthesis of Thiadiazole, Thiadiazine, and Pyrazole Derivatives." Phosphorus, Sulfur, and Silicon and the Related Elements 184, no. 7 (2009): 1653–64. http://dx.doi.org/10.1080/10426500701752960.

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15

I, Khan. "Synthesis of 3, 5-Disubstituted-Tetrahydro-2h-1, 3, 5-Thiadiazine2-Thiones Derivatives and their Metal Complexes as Potential Bioactive Agents." International Journal of Pharmacognosy & Chinese Medicine 7, no. 2 (2023): 1–12. http://dx.doi.org/10.23880/ipcm-16000239.

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Thiadiazine thione derivatives (2-(5-(2-.hydroxyethyl)-2-thioxo-1,3,5-thiadiazinane-3-yl) Acetic acid, 2-(5-.butyl-6-thioxo.-1, 3, 5-thiadiazinane-3-yl) Acetic acid, 2, 1 and 2 were synthesized by the reaction of alkyl primary amines (glycine, butylamine) with carbon disulfide and potassium hydroxide followed by addition of formaldehyde and various primary amines (ethanolamine, glycine) in phosphate buffer medium. The synthesized compounds were transformed into organometallic complexes (3-12) Ni (II), Co (II), Cu (II), Zn (II) and Fe (II) using their metal salts. The structure determinations o

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16

Martinez, Ana, Carmen Gil, Ana Castro, et al. "Benzothiadiazine Dioxide Human Cytomegalovirus Inhibitors: Synthesis and Antiviral Evaluation of Main Heterocycle Modified Derivatives." Antiviral Chemistry and Chemotherapy 14, no. 2 (2003): 107–14. http://dx.doi.org/10.1177/095632020301400206.

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The benzothiadiazine dioxide derivatives are potent non-nucleoside human cytomegalovirus (HCMV) inhibitors. As part of our comprehensive structure-activity relationship (SAR) study of these compounds, we have now proposed structural modifications on the heterocyclic moiety both on the number and the nature of the fused heterocycle and on the kind of heteroatoms pre-sent on it. Synthesis of these new compounds (benzyl derivatives of thiadiazines, thienothiadiazines, benzothienothiadiazines and quinazolines) and the antiviral evaluation against HCMV has been performed. SAR investigation on this

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17

Idrees, M., Naqui J. Siddiqui, Yogita G. Bodkhe, and Satish Kola. "Synthesis and Characterization of Novel 1,3,5-Thiadiazine Derivatives Integrated with Quinoline Moiety as Potent Antimicrobial Agents." Asian Journal of Organic & Medicinal Chemistry 5, no. 2 (2020): 149–55. http://dx.doi.org/10.14233/ajomc.2020.ajomc-p262.

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An expeditious synthesis of series of novel 1,3,5-thiadiazine (5a-f) and (6a-f) derivatives have been described. These compounds were synthesized by reaction of 1-(N-((6-methyl-2-(p-tolyloxy)quinoline- 3-yl)methylene)carbamimidoyl)-3-arylthiourea (3a-b) derivatives with N-aryl isocyanodichloride (4a-c) in chloroform followed by basification with dilute NH4OH to give the target compounds 5a-f; which were acetylated further to afford six novel 1,3,5-thiadiazin-3-(6H)-yl)ethanone (6a-f) derivatives. Synthesis of intermediate compounds 3a-b was obtained by reacting 6-methyl-2-(p-tolyloxy)quinoline

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18

Hassan, Alaa A., Ashraf A. Aly, Sara M. Mostafa, and Dietrich Döpp. "Formation of thiadiazole, thiadiazine, thiadiazepine and pyrazole derivatives in the reaction of 2,4-disubstituted thiosemicarbazides with tetracyanoethylene." Arkivoc 2018, no. 3 (2018): 200–211. http://dx.doi.org/10.24820/ark.5550190.p010.368.

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19

Bakavoli, Mehdi, Seyed Mohammad Seyedi, Ali Shiri, Sattar Saberi, Mahmoud Gholami, and Hamid Sadeghian. "Synthesis of new Derivatives of Pyrimido[5,4-e][1,2,4]triazolo[3,4-b] [1,3,4]Thiadiazine and Their Enzyme Inhibitory Activity Assessment on Soybean 15-lipoxygenase." Journal of Chemical Research 37, no. 1 (2013): 48–50. http://dx.doi.org/10.3184/174751912x13549029453945.

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The synthesis of new derivatives of pyrimido[5,4- e][1,2,4]triazolo[3,4- b][1,3,4]thiadiazine is described. These derivatives have a wide range of medicinal applications. Their inhibitory activity against the enzyme 15-lipoxygenase was also investigated.

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20

Tawfeek, Hendawy N., Alshaimaa Abdelmoez, Kholood A. Dahlous, et al. "Convenient synthesis and X-ray determination of 2-amino-6H-1,3,4-thiadiazin-3-ium bromides endowed with antiproliferative activity." RSC Advances 14, no. 25 (2024): 17866–76. http://dx.doi.org/10.1039/d4ra02531h.

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21

Bermello, Julieta Coro, Rolando Pérez Piñeiro, Lianet Monzote Fidalgo, Hortensia Rodríguez Cabrera, and Margarita Suárez Navarro. "Thiadiazine Derivatives as Antiprotozoal New Drugs." Open Medicinal Chemistry Journal 5 (March 9, 2011): 51–60. http://dx.doi.org/10.2174/1874104501105010051.

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22

Filimonov, Aleksandr, Olga Luzina, and Nariman Salakhutdinov. "New Heterocyclic Derivatives of Usnic Acid." Chemistry Proceedings 3, no. 1 (2020): 66. http://dx.doi.org/10.3390/ecsoc-24-08459.

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New heterocyclic derivatives of usnic acid have been obtained by the reaction of bromousnic acid with CS2-based nucleophiles. A series of compounds with dithiolane, 1,3,4-thiadiazine, and thiophene fragments was synthesized.

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23

Zaleska, Barbara, Bartosz Trzewik, Jacek Grochowski, and Paweł Serda. "A Novel Route to 1,2,3-Thiadiazole, 1,3,4-Thiadiazine, and 1,2,5-Triazepine Derivatives." Synthesis, no. 16 (2003): 2559–63. http://dx.doi.org/10.1055/s-2003-42414.

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24

El-Saghier, Ahmed, Asmaa Abdul-Baset, Omer El-Hady, and Asmaa Kadry. "Synthesis of Some New Thiadiazole/Thiadiazine derivatives as potent Biologically Active Compounds." Sohag Journal of Sciences 8, no. 3 (2023): 371–75. http://dx.doi.org/10.21608/sjsci.2023.213273.1083.

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25

Myrko, I. I., T. I. Chaban, V. V. Ohurtsov, I. V. Drapak, and V. S. Matiichuk. "Synthesis and study of the anticancer activity of some new 7H-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazines." Current issues in pharmacy and medicine: science and practice 14, no. 3 (2021): 320–27. http://dx.doi.org/10.14739/2409-2932.2021.3.240361.

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The problem of finding effective low-toxic anticancer agents is one of the most important in modern medicine and pharmacy. Despite a large selection of anticancer drugs and a variety of mechanisms of their action, the effectiveness of existing drugs continues to be insufficient. Among the numerous natural and synthetic heterocyclic compounds that exhibit anticancer activity, 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives, which are able to initiate different pathways of tumor cell death. Based on this, the synthesis of new derivatives of this class of compounds and the study of their

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26

Boraei, Ahmed T. A., Hazem A. Ghabbour, Mohamed S. Gomaa, El Sayed H. El Ashry, and Assem Barakat. "Synthesis and Anti-Proliferative Assessment of Triazolo-Thiadiazepine and Triazolo-Thiadiazine Scaffolds." Molecules 24, no. 24 (2019): 4471. http://dx.doi.org/10.3390/molecules24244471.

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A series of triazolo-thiadiazepines 4a–k were synthesized with excellent yields using dehydrated PTSA as a catalyst in toluene. Two triazolo-thiadiazines were obtained; 8a was formed directly by reflux in ethanol, whereas, PTSA promoted the formation of 8b. The molecular structure of the formed triazolo-thiadiazepines is identical to the imine-form 4a–k and not the enamine-tautomer 6a–k. The structures of the newly synthesized triazolo-thiadiazepines 4a–k and triazolo-thiadiazines 8a–b were elucidated using NMR (1H, and 13C), 2D NMR, HRMS, and X-ray single crystal. Furthermore, 4a was deduced

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27

Hritzová, Oľga. "Reactions of vinylene diisothiocyanate with aniline, N-benzylidenemethylamine and N,N'-dicyclohexylcarbodiimide." Collection of Czechoslovak Chemical Communications 50, no. 10 (1985): 2170–73. http://dx.doi.org/10.1135/cccc19852170.

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Reaction of vinylene diisothiocyanate with aniline, N-benzylidenemethylamine and N,N'-dicyclohexylcarbodiimide affords the stable 1-(anilinothiocarbonyl)-4-imidazoline-2-thione and 1,3,5-thiadiazine derivatives, respectively.

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28

Pradip, P. Deohate, P. Deohatc Jyoti, and N. Berad B. "Synthesis of novel benzo-1,2,5-thiadiazines, their antimicrobial activity and isomerization into benzo-1,2,4-triazines." Journal of India Chemical Society Vol 81, Sep 2004 (2004): 775–77. https://doi.org/10.5281/zenodo.5833095.

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P. G. Department of Chemistry, Shri Shivaji Science College, Amravati-444 603, India <em>E-mail</em>: pradip222091 @yahoo.co.in <em>Manuscript received 23 April 2003. revised 12 March 2004. accepted 6 April 2004</em> Benzo[<em>c</em>]-6-aryl/alkylimino-1,2,5-thiadiazines (4a-g) have been obtained by the basification of benzo[<em>c</em>]-6-aryl/alkylimino-1 ,2,5- thiadiazine dihydroiodides (3a-g). The latter were synthesized by the oxidative cyclisation of substituted 1-aryl/alkyl- 3-(2' -aminophenyl)thiocarbamides (2a-g) by ethanolic iodine. Compounds (4a-g) on acylation with acetic anhydr

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29

Wang, Dongyin, Wei Liu, Fei Yi, Yongli Zhao, and Junmin Chen. "Palladium-catalyzed direct C–H arylation of 3-aryl-2H-benzo[1,2,4]thiadiazine 1,1-dioxides: an efficient strategy to the synthesis of benzothiadiazine-1,1-dioxide derivatives." Organic & Biomolecular Chemistry 14, no. 6 (2016): 1921–24. http://dx.doi.org/10.1039/c5ob02196k.

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An efficient strategy to the synthesis of 3-aryl-2H-benzo[1,2,4]thiadiazine 1,1-dioxide derivatives via palladium-catalyzed direct arylation of benzothiadiazine-1,1-dioxides with various aryl iodides is described.

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30

Bibik, Elena, Oksana Yaroshevskaya, Andrey Demenko, Konstantin Frolov, Viktor Dotsenko, and Sergey Kryvokolisko. "The effect of derivatives of tetrahydropyrido[2,1-b][1,3,5] thiadiazine on hematologic indices of rats with subacute parotitis." Research Results in Pharmacology 4, no. 2 (2018): 77–83. http://dx.doi.org/10.3897/rrpharmacology.4.28305.

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Introduction: Regardless of belonging of NSAIDs to one or another chemical group, they all have common side effects that can occur when using these drugs for a long or short period. One type of toxicity in the spectrum of side effects of modern non-steroidal anti-inflammatory drugs is hematotoxicity. Objectives: to study the indices characterizing the red and white hematopoiesis in a clinical blood examination in animals with a simulated inflammation process against a background of pharmacocorrection with original thiadiazine derivatives. Methods: The experiments were carried out on 48 white p

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31

Bibik, Elena, Oksana Yaroshevskaya, Andrey Demenko, Konstantin Frolov, Viktor Dotsenko, and Sergey Kryvokolisko. "The effect of derivatives of tetrahydropyrido[2,1-b][1,3,5] thiadiazine on hematologic indices of rats with subacute parotitis." Research Results in Pharmacology 4, no. (2) (2018): 77–83. https://doi.org/10.3897/rrpharmacology.4.28305.

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Introduction: Regardless of belonging of NSAIDs to one or another chemical group, they all have common side effects that can occur when using these drugs for a long or short period. One type of toxicity in the spectrum of side effects of modern non-steroidal anti-inflammatory drugs is hematotoxicity. Objectives: to study the indices characterizing the red and white hematopoiesis in a clinical blood examination in animals with a simulated inflammation process against a background of pharmacocorrection with original thiadiazine derivatives. Methods: The experiments were carried out on 48 white p

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32

Hassan, Alaa A., Yusria R. Ibrahim, and Ahmed M. Shawky. "Indazole, oxathiadiazole, and thiadiazine derivatives from thiosemicarbazides." Journal of Sulfur Chemistry 28, no. 2 (2007): 211–22. http://dx.doi.org/10.1080/17415990701230596.

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Abdel-Rahman, Taha M. "Synthesis, Reactions, and Anticancer Activity of Some 1,3,4-Thiadiazole/Thiadiazine Derivatives of Carbazole." Phosphorus, Sulfur, and Silicon and the Related Elements 181, no. 8 (2006): 1737–54. http://dx.doi.org/10.1080/10426500500536572.

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Hassan, A., A. Mourad, K. El-Shaieb, and A. Abou-Zied. "Synthesis of 1,3,4-Thiadiazole, 1,3,4-Thiadiazine, 1,3,6-Thiadiazepane and Quinoxaline Derivatives from Symmetrical Dithiobiureas and Thioureidoethylthiourea Derivatives." Molecules 10, no. 7 (2005): 822–32. http://dx.doi.org/10.3390/10070822.

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Bibik, Elena, Oksana Yaroshevskaya, Anton Yeryomin, Konstantin Frolov, Victor Dotsenko, and Sergey Kryvokolisko. "STUDY OF ANALEPTIC ACTIVITY OF TETRAHYDROPYRIDO [2,1-b] [1,3,5] TIADIAZINE DERIVATIVES." Research Results in Pharmacology 3, no. (4) (2017): 20–25. https://doi.org/10.18413/2313-8971-2017-3-4-20-25.

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Introduction: Our goal is to conduct an investigation of the analeptic activity of the tetrahydropyrido [2,1-b] [1,3,5] thiadiazine derivative group. Materials and methods: Biological studies were carried out on 78 white pedigreed mature sexually transmitted rats of both sexes weighing 230-270 g in the autumn-winter period. The test substances were administered intragastrically at a dose of 5 mg/kg 1 hour prior to the induction of anesthesia. Animals of the control group received thiopental sodium at a dose of 70 mg/kg. As the reference preparation, sodium caffeine-benzoate was used intraperit

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Li, Yang, Chen-Fei Liu, Xin-Yang Liu, Yan-Jun Xu, and Lin Dong. "Rhodium(iii)-catalyzed tandem reaction: efficient synthesis of dihydrobenzo thiadiazine 1-oxide derivatives." Organic Chemistry Frontiers 6, no. 9 (2019): 1458–62. http://dx.doi.org/10.1039/c9qo00112c.

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A tandem annulation reaction triggered by rhodium(iii)-catalyzed C–H bond functionalizations has been well developed for highly efficient synthesis of dihydrobenzo thiadiazine 1-oxide derivatives from free NH-sulfoximine and two-component benzyl azides.

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Bibik, Elena Yu, Anna A. Saphonova, Anton V. Yeryomin, Konstantin A. Frolov, Victor V. Dotsenko, and Sergey G. Krivokolysko. "Study of analeptic activity of tetrahydropyrido [2,1-b] [1,3,5] tiadiazine derivatives." Research Results in Pharmacology 3, no. 4 (2017): 20–25. http://dx.doi.org/10.18413/2313-8971-2017-3-4-20-25.

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Introduction: Our goal is to conduct an investigation of the analeptic activity of the tetrahydropyrido [2,1-b] [1, 3, 5] thiadiazine derivative group. Materials and Methods: Biological studies were carried out on 78 white pedigreed mature sexually transmitted rats of both sexes weighing 230-270 g in the autumn-winter period. The test substances were administered intragastrically at a dose of 5 mg/kg 1 hour prior to the induction of anesthesia. Animals of the control group received thiopental sodium at a dose of 70 mg/kg. As the reference preparation, sodium caffeinebenzoate was used intraperi

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38

Özen, Gürkan, Erhan Palaska, and Emirhan Nemutlu. "Determination of Acidity Constant (pKa), Lipophilic Partition (LogP) and Distribution Coefficients (LogD) Values of Some 3-(2-Phenylethyl)-Tetrahydro-2H-1,3,5-Thiadiazine-2-Thione-5-Acetic Acid Derivatives." Cumhuriyet Science Journal 45, no. 4 (2024): 673–82. https://doi.org/10.17776/csj.1538755.

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Invasive fungal infections pose a significant threat to human health, emphasizing the urgent need for new and effective antifungal agents. 3,5-Disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives have shown promising antifungal activity. This study focused on characterizing the physicochemical properties, specifically the acidity constant (pKa), lipophilic partition coefficient (logP), and distribution coefficient (logD), of four 3-(2-phenylethyl)-tetrahydro-2H-1,3,5-thiadiazine-2-thione-5-acetic acid derivatives (EP1, EP2, EP3, and EP4) with varying α-carbon substituents. pKa va

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Kuz’mich, N. N., B. Yu Lalaev, I. P. Yakovlev, T. L. Semakova, and V. E. Zakhs. "Thiobenzohydrazides and dithiocarbazates in the synthesis of new 1,3,4-thiadiazine and 1,3,4-thiadiazole derivatives." Russian Journal of General Chemistry 79, no. 7 (2009): 1583–84. http://dx.doi.org/10.1134/s1070363209070263.

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HASSAN, A. A. "ChemInform Abstract: A Novel Synthesis of Thiadiazole and Thiadiazine Derivatives via Charge-Transfer Complexation." ChemInform 25, no. 44 (2010): no. http://dx.doi.org/10.1002/chin.199444172.

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Djudjic, R., M. Trkovnik, and D. Kitan. "SYNTHESIS OF THIADIAZINE AND ARYLMETHINEAZOTHIAZOLONE DERIVATIVES OF COUMARIN." Organic Preparations and Procedures International 17, no. 3 (1985): 206–10. http://dx.doi.org/10.1080/00304948509355503.

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Hamdi, Maamar, Oualid Talhi, Artur Silva, et al. "Synthetic Approach Toward Heterocyclic Hybrids of [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazines." Synlett 29, no. 11 (2018): 1502–4. http://dx.doi.org/10.1055/s-0036-1591991.

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The synthesis of novel heterocyclic [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine hybrids by a bimolecular reaction of 2-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)phenol with an aromatic or heterocyclic α-bromoacetyl derivatives is described. This synthetic procedure starts from an unprotected phenol.

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Witvrouw, M., M. E. Arranz, C. Pannecouque, et al. "1,1,3-Trioxo-2H,4H-Thieno[3,4-e][1,2,4]Thiadiazine (TTD) Derivatives: a New Class of Nonnucleoside Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitors with Anti-HIV-1 Activity." Antimicrobial Agents and Chemotherapy 42, no. 3 (1998): 618–23. http://dx.doi.org/10.1128/aac.42.3.618.

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ABSTRACT We report the development of a new group of nonnucleoside reverse transcriptase inhibitors (NNRTIs). One of the most active congeners of this series of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives, i.e., 2-(3-fluorobenzyl)-4-cyanomethylen-1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine) (QM96639) was found to inhibit human immunodeficiency virus (HIV) type 1 [HIV-1 (IIIB)] replication in MT-4 cells at a concentration of 0.09 μM. This compound was toxic for the host cells only at a 1,400-fold higher concentration. The TTD derivatives proved effective against

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Afrough, T., M. Bakavoli, and H. Eshghi. "Synthesis and characterisation of new 3-methyl-6-[1-(pyrimidin-4-yl)ethyl]-5H-pyrimido[5,4-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives." Journal of Chemical Research 41, no. 7 (2017): 376–79. http://dx.doi.org/10.3184/174751917x14967701766978.

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A new series of 3-methyl-6-[1-(pyrimidin-4-yl)ethyl]-5 H-pyrimido[5,4- e][1,2,4]triazolo[3,4- b][1,3,4]thiadiazine derivatives was synthesised through the condensation reaction of 5-bromo-4-[1-(5-bromo-2,6-dichloropyrimidin-4-yl)ethyl]-2-chloro-6-methylpyrimidine and 4-amino-5-methyl-4 H-1,2,4-triazole-3-thiol.

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Alkorta, Ibon, Pilar Goya, Juan Antonio Paez, and Wolfgang Pfleiderer. "Synthesis and Physico-Chemical Properties of 6- and 7-Monosubstituted Pyrazino|2,3-c̱|-1,2,6-thiadiazine 2,2-Dioxides." Pteridines 2, no. 1 (1990): 3–21. http://dx.doi.org/10.1515/pteridines.1990.2.1.3.

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Summary Selective procedures for the synthesis of 6- and of 7-monosubstituted derivatives of pyrazinoI2,3-c̱|-1 ,2,6- thiadiazine 2,2-dioxide and their reactions with N-bromosuccinimide are reported. The structures of the compounds are discussed on the basis of 1 H -, 13C_ NMR and UV spectroscopic data. The pKa values of the compounds have also been determined.

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Monzote, Lianet, Ana Montalvo, Lisset Fonseca, Rolando Pérez, Margarita Suárez, and Hortensia Rodríguez. "In vitro Activities of Thiadiazine Derivatives against Leishmania amazonensis." Arzneimittelforschung 55, no. 04 (2011): 232–38. http://dx.doi.org/10.1055/s-0031-1296850.

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Muelas, Susana, Rossanna Di Maio, Hugo Cerecetto, et al. "New thiadiazine derivatives with activity against Trypanosoma cruzi amastigotes." Folia Parasitologica 48, no. 2 (2001): 105–8. http://dx.doi.org/10.14411/fp.2001.015.

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Yang, Yajun, Ziming Feng, Jianshuang Jiang, Yanan Yang, Xiandao Pan, and Peicheng Zhang. "Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazine Derivatives." CHEMICAL & PHARMACEUTICAL BULLETIN 59, no. 8 (2011): 1016–19. http://dx.doi.org/10.1248/cpb.59.1016.

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Rahimizadeh, M., M. Nikpour, and M. Bakavoli. "New route to pyrimido[4,5-e][1,3,4]thiadiazine derivatives." Journal of Heterocyclic Chemistry 44, no. 2 (2007): 463–65. http://dx.doi.org/10.1002/jhet.5570440230.

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Sarwar, Sarah, Nadia Sarwar, Haleema Ali, et al. "Targeting Cutaneous Leishmaniasis with Thiadiazine Thione Derivatives: An In Vivo Study of Its Anti-Inflammatory, Anti-Pyretic, Anti-Nociceptive, and Anti-Sedative Properties." Biomedicines 13, no. 1 (2025): 93. https://doi.org/10.3390/biomedicines13010093.

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Background/Objectives: Thiadiazine thione (THTT) has gained significant interest owing to its pharmacological potentials, particularly its antiparasitic and anti-inflammatory properties. Leishmaniasis is a clinical syndrome caused by infection with Leishmania species and is associated with an inflammatory response and nociception. The available treatments against leishmaniasis are inadequate, as they are associated with high cost, toxicity, and increased resistance. Methods: In the current study, the antileishmanial potential of five Thiadiazine thione derivatives (C1–C5) was evaluated in vivo

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