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Dissertations / Theses on the topic 'Thiamin pyrophosphate'

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1

Iqbal, Amjid. "Synthesis and evaluation of thiamin diphosphate analogues." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607797.

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2

Thomson, Andrew Campbell. "Macrocyclic thiazolium salts as models for thiamin pyrophosphate-dependent enzymes." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614841.

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3

Tunc, Meral. "The molecular genetic regulation of thiamin biosynthesis in plants." abstract and full text PDF (free order & download UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3307578.

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4

Nguyen, Trinh Doan Thi. "Thiamine pyrophosphate riboswitches in Chlamydomonas reinhardtii : understanding their nature to generate tools for biotechnology." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708526.

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5

Erixon, Karl Magnus. "Synthesis and evaluation of thiamine pyrophosphate analogues." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611168.

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6

Aljuaid, Bandar. "Identification and analysis of Arabidopsis thiamine pyrophosphate transporters." Thesis, University of Essex, 2017. http://repository.essex.ac.uk/19430/.

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Thiamine pyrophosphate (TPP) serves as a cofactor in universal metabolic pathways, including glycolysis, the pentose phosphate pathway (PPP) and the tricarboxylic acid cycle; moreover, it is essential for the proper functioning of all organisms. Recently, several steps of the plant thiamine biosynthetic pathway have been characterised, and a mechanism of feedback regulation for thiamine biosynthesis via riboswitching has been unravelled. In plants, thiamine is made in the chloroplasts and then transferred to the cytosol to generate the active form of thiamine, TPP. The mitochondria and chlorop
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7

Chen, Yang-Ting(Percival Yang Ting). "Structural insights into conformationally-gated reactions catalyzed by thiamine pyrophosphate-dependent enzymes." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122450.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Thiamine pyrophosphate (TPP)-dependent enzymes utilize TPP as a biological carbanion to initiate reactions on substrates with carbonyl carbon(s), such as pyruvate and 2-oxoglutarate, two central metabolites. This thesis presents structural analyses of three TPP-dependent enzymes. Most interestingly, each mechanism of three proteins studied contains a gated step that is drastically accelerated by 3-5 orders of magnitudes t
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8

Sopaci, Saziye Betul. "Microorganism Mediated Stereoselective Bio-oxidation And Bio-hydrogenation Reactions And Thiamine Pyrophosphate Dependent Enzyme Catalyzed Enantioselective Acyloin Reactions." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/2/12610516/index.pdf.

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In this study various microbial and enzymatic methods developed for enantioselective acyloin synthesis for preparation of some pharmaceutically important intermediates. By performing Aspergillus flavus (MAM 200120) mediated biotransformation, enantioselective bio-oxidation of meso-hydrobenzoin was achieved with a high ee value (76%). Racemic form of hydrobenzoin was also employed for the same bio-oxidation process and this bioconversion was resulted in accumulation of meso form (&gt<br>90% yield) confirming the suggested mechanism of oxidation-reduction sequence of hydrobenzoin. Wieland-Miesch
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9

Chabrière, Eric. "Etude structurale de la pyruvate:ferrédoxine oxydoréductase de Desulfovibrio africanus par cristallographie des rayons X : vers une meilleure connaissance du mécanisme réactionnel du cofacteur thiamine pyrophosphate." Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10094.

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Les pyruvate : ferredoxine oxydoreductases (pfor) sont des enzymes qui, chez la plupart des organismes anaerobes, catalysent la decarboxylation oxydative du pyruvate en utilisant le cofacteur thiamine pyrophosphate, suivant la reaction : pyruvate + coa-sh acetyl-coa + co 2 + 2e + h + dans cette these, nous expliquons comment nous avons resolu, par cristallographie, la premiere structure tridimensionnelle d'une pfor, celle de desulfovibrio africanus, une bacterie sulfato-reductrice anaerobe. Nous montrons aussi comment l'analyse de cette structure a apporte une meilleure comprehension du mecani
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10

Garcia, Assuero Faria. "Thi1, uma proteína envolvida na síntese de tiamina em Arabidopsis thaliana: análises estruturais do mutante Thi1 (A140V)." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-04102011-161654/.

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A forma ativa da vitamina B1, tiamina pirofosfato (TPP), é um cofator indispensável para certas enzimas que atuam no metabolismo de carboidratos e aminoácidos. Sua biossíntese se dá pela formação independente de suas partes componentes pirimidina e tiazol. Em procariotos a via de síntese para vitamina B1 já foi esclarecida, entretanto em eucariotos ainda existem ainda algumas lacunas a serem preenchidas. Em Arabidopsis thaliana a proteína Thi1 é possivelmente a responsável pela síntese do motivo tiazólico, uma vez que um composto relacionado a TPP foi encontrado em sua estrutura. Neste trabalh
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11

Van, Liefferinge François. "Molecular basis of the transport of small inorganic ions and thiamine pyrophosphate by the Voltage-Dependent Anion Channel and by a specific transporter of the mitochondrial inner membrane. Study by structure-guided simulations." Doctoral thesis, Universite Libre de Bruxelles, 2021. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/331176.

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The essential cellular functions of the mitochondrion require the exchange of a wide variety of molecules across its two membranes, which is carried out by different membrane proteins.The Voltage-Dependent Anion Channel (VDAC) located in the mitochondrial outer membrane (MOM) is responsible for the passage of various ions and small molecules to and from the intermembrane space. It is also involved in the regulation of cellular processes through its interactions with lipids or other proteins.At the MOM level, we studied the transport, through VDAC, of small inorganic ions and of thiamine pyroph
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12

Webb, Eric. "Studies of thiamine pyrophosphate synthesis and regulation in Salmonella typhimurium." 1999. http://catalog.hathitrust.org/api/volumes/oclc/45370845.html.

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13

Eriksson, Hanna. "Implementation of thiamine pyrophosphate (TPP) riboswitches as synthetic biosensors and regulatory tools in cyanobacteria." Thesis, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-355554.

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The natural occurrence of the non-mevalonate (also called MEP after the compound methyl-erythriol phosphate) pathway in the model cyanobacterium Synechocystis sp. PCC 6803 allows for biosynthesis of various high-value terpenoid compounds. An important co-factor of this pathway is thiamine pyrophosphate (TPP), coenzyme to the 1- deoxy-D-xylulose-5-phosphate synthase (DXS) reaction in the initial step of the MEP pathway. Concurrently, TPP biosynthesis derives partially from 1-deoxy-D-xylulose phosphate, the product of DXS. This makes TPP a potentially significant measure of MEP pathway activity,
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14

Enos-Berlage, Jodi Lynn. "Characterization of thiamine-pyrophosphate synthesis independent of the purF enzyme (phosphoribosylpyrophosphate amidotransferase) in Salmonella typhimurium." 1998. http://catalog.hathitrust.org/api/volumes/oclc/41148516.html.

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15

Tsai, Chuan-Mei, and 蔡娟美. "Thiamine pyrophosphatase and lysosomal activity in corpora allata of Diploptera punctata adult females." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/21925214124168723931.

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