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Journal articles on the topic 'Thiazole analogues'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Pelageev, Dmitry N., Svetlana M. Kovach, Nadezhda N. Balaneva, et al. "Synthesis and biological activity of thiazole--carbohydrate conjugates based on thiacarpine, an analogue of the cytotoxic alkaloid from the ascidian <em>Polycarpa aurata</em>." Mendeleev Communications 35, no. 1 (2025): 66–68. https://doi.org/10.71267/mencom.7522.

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Based on bis(2-amino-4-phenyl-5-thiazolyl) disulfides, thiazole analogues of polycarpine, a cytotoxic alkaloid from the ascidian <em>Polycarpa aurata</em>, a wide range of thiazole--carbohydrate conjugates based on D-glucose and D-xylose has been obtained. Antitumor and antimicrobial activity for the synthesized compounds has been studied.

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2

Sharma, Diksha, Archana Sharma, Rakesh Pahwa, Avtar Chand Rana, and Prabodh Chander Sharma. "Design, synthesis, anti-infective and anti-cancer potential of thiazole based Pyrazoles bearing benzothiazole moiety." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4622–28. http://dx.doi.org/10.55522/jmpas.v11i2.2470.

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A new series of (E)-6-methyl-N-((3-phenyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-4-yl)methylene)benzo[d]thiazol-2-amine derivatives was developed. Structural investigation of the synthesized derivatives was carried out by several instrumental method of analysis like IR, and 1H-NMR spectroscopy. The titled analogues were examined for in-vitro anticancer and antiinfective activities. The biological findings specified that analogues 5a, 5b, 5d, 5e, 5f and 5g showed most potent antibacterial activity (MIC 62.5-250μg/mL) and 5a, 5e, 5f and 5g displayed most potent antifungal action (MIC 62.5-500 μg/mL

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3

Tokárová, Zita, Renáta Gašparová, Natália Kabaňová, Marcela Gašparová, and Róbert Balogh. "Hemetsberger–Knittel and Ketcham Synthesis of Heteropentalenes with Two (1:1), Three (1:2)/(2:1) and Four (2:2) Heteroatoms." Reactions 4, no. 2 (2023): 254–73. http://dx.doi.org/10.3390/reactions4020015.

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The synthetic methods leading to furo[3,2-b]pyrroles and thiazolo [5,4-d]thiazoles are reviewed herein. Furo-, thieno- and seleno [3,2-b]pyrroles are related to heteropentalenes, containing two heteroatoms in the entire structure, one each per core. The synthetic approach follows the Hemetsberger–Knittel protocol covering three reaction steps—the nucleophilic substitution of halogen-containing aliphatic carboxylic acid esters, Knoevenagel condensation and, finally, thermolysis promoting the intramolecular cyclocondensation to O,N-heteropentalene. The Hemetsberger–Knittel reaction sequence is a

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4

Ram, Sevak Verma*1 Nitin Mittal2 Bhumika Yogi3 Shikha Sharma4 Abhishek Mishra5. "A Review On Chemistry And Antimicrobial Activity Of Thiazole." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 1184–201. https://doi.org/10.5281/zenodo.10893122.

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The recent study classe of five-membered heterocyclic compounds is thiazoles. Several thiazoles, both synthetic and natural, and their derivatives exhibited strong biological activity. Thiazole derivatives exhibit strong antibacterial action against a variety of bacterial species & diseases because of their special characteristics. As a result, the current study assigns different thiazoles and there derivatives' antimicrobial activity. Through the use of many databases, every pertinent piece of literature has been examined. The important studies on the antibacterial activity of thiazole de

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5

JishaMol., V* Binsalma K.S Vivek M. Rubeena V. K. "SYNTHESIS, CHARACTERISATION AND INVITRO ANTIBACTERIAL SCREENING OF NOVEL THIAZOLE ANALOGUES." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 1944–51. https://doi.org/10.5281/zenodo.831662.

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Thiazole containing N=C-S moiety exhibit broad spectrum of biological activities like fungicidal, antimicrobial, antitubercular activities and thiazole possess biological activities like bactericidal, antifungal, analgesic, antiinflammatory, diuretic, CNS depressant and anticancer activity. Recent literature reports explore the biological importance of thiazole analogues as antibacterial agent. The aim and objective of the present investigation is to develop novel thiazole analogues. In this study 3 novel thiazole analogues were synthesised by Schiff’s reaction of 2-amino-4-phenylthiazole with

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6

Stankova, Ivanka, Stoyan Schichkov, Kalina Kostova, and Angel Galabov. "New Analogues of Acyclovir – Synthesis and Biological Activity." Zeitschrift für Naturforschung C 65, no. 1-2 (2010): 29–33. http://dx.doi.org/10.1515/znc-2010-1-205.

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New acyclovir esters with peptidomimetics were synthesized and evaluated in vitro for their antiviral activity against the replication of Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The infl uence of peptidomimetics containing oxazole and thiazolyl-thiazole moieties on the antiviral activity is also reported. The esters were synthesized using the coupling reagents N-ethyl-N’-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and N,N-dimethyl-4-aminopyridine (DMAP) as a catalyst.

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7

Diness, Frederik, Daniel S. Nielsen, and David P. Fairlie. "Synthesis of the Thiazole–Thiazoline Fragment of Largazole Analogues." Journal of Organic Chemistry 76, no. 23 (2011): 9845–51. http://dx.doi.org/10.1021/jo201675r.

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8

Gargala, Gilles, Laetitia Le Goff, Jean-Jacques Ballet, Loic Favennec, Andrew V. Stachulski, and Jean-François Rossignol. "Evaluation of New Thiazolide/Thiadiazolide Derivatives Reveals Nitro Group-Independent Efficacy against In Vitro Development of Cryptosporidium parvum." Antimicrobial Agents and Chemotherapy 54, no. 3 (2010): 1315–18. http://dx.doi.org/10.1128/aac.00614-09.

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ABSTRACT Thirty-nine new thiazolide/thiadiazolide compounds were compared with the nitrothiazole nitazoxanide for activity against Cryptosporidium parvum development in HCT-8 cells. Twenty-seven agents exerted ≥90% inhibition. Agents with a lower 50% inhibitory concentration (IC50) than nitazoxanide were either NO2 or halogen 5 substituted on the thiazole moiety. Other 5 substitutions such as methyl, C3H7, C6H11, H, SO2CH3, and SCH3 negatively impacted activity. Five-substituted deacetylated analogues exhibited higher IC50s than their acetylated counterparts. Halogeno-thiazolide/thiadiazolides

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9

Lamberth, Clemens, Sarah Sulzer-Mosse, and Peter Kubizna. "Synthesis of Ring-Opened Analogues of Oxysterol-Binding Protein-Inhibiting Piperidinyl-thiazole Fungicides." Synlett 28, no. 17 (2017): 2277–80. http://dx.doi.org/10.1055/s-0036-1588473.

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Novel aminoethyl-, aminopropyl-, and aminobutyl-substituted thiazole-4-carboxamides have been prepared which are ring-opened analogues of piperidinyl-thiazole fungicides. Depending of the chain length, completely different synthetic approaches had to be chosen which vary from a Sonogashira coupling with a 2-bromothiazole derivative to a thiazole ring construction from different β- and δ-amino acids.

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10

Goldstein, BM, JF Leary, BA Farley, VE Marquez, PC Levy, and PT Rowley. "Induction of HL60 cell differentiation by tiazofurin and its analogues: characterization and efficacy." Blood 78, no. 3 (1991): 593–98. http://dx.doi.org/10.1182/blood.v78.3.593.bloodjournal783593.

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Among inducers of myeloid differentiation for leukemic cells, tiazofurin is of special interest because its mechanism of action is known; it inhibits inosine monophosphate dehydrogenase and thus decreases the guanine nucleotide pool. Reported here are three aspects of tiazofurin induction of myeloid differentiation in HL60 human acute promyelocytic leukemia cells. First, inductive efficacy was evaluated for analogues ara-tiazofurin, xylo-tiazofurin, and selenazofurin, for dinucleotide anabolites thiazole-4-carboxamide adenine dinucleotide (TAD) and selenazole-4-carboxamide adenine dinucleotide

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11

Shibata, Kotaro, Kotaro Shibata, Narendra N. Pati, and Yasuhide Inokuma. "Exploration of Synthesis and Coordination Chemistry of Thiazole-Containing Calix[3]Pyrroles." ECS Meeting Abstracts MA2024-01, no. 14 (2024): 1117. http://dx.doi.org/10.1149/ma2024-01141117mtgabs.

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Calix[n]pyrroles have been used as powerful and specific receptors and as extractants for anions and ion pairs over the past 20 years. In the recent past, calix[4]pyrroles have been used as systems that can move ions and ion pairs over lipophilic membranes [1]. Unfortunately, the coordination chemistry of calix[n]pyrroles hardly explored. The ring-contracted analog of calix[n]pyrrole, calix[3]pyrrole, was synthesized and recently published [2]. The structure of calix[3]pyrrole and its analogues is strained, and they show an appealing strain-induced ring expansion response. On the other hand, t

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12

Tarasenko, Dmytro, Andrii Chumak, Oleksii Kolomoitsev, Volodymyr Kotlyar, and Andrey Doroshenko. "New 2-thiazol-5-yl-benzimidazoles: synthesis and determining of their potential as chemosensor reagents for polyvalent metal ions." Kharkov University Bulletin Chemical Series, no. 39 (October 12, 2022): 38–44. http://dx.doi.org/10.26565/2220-637x-2022-39-04.

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Thiabendazole and its analogues are widely used and reasonably well studied in terms of their biological activity, while their potential as chemosensory compounds with optical detection and sensitivity to metal ions remains unexplored. On the other hand, the introduction of a thiazole ring into the heteroaromatic system of benzimidazole significantly expands the directions of practical application of benzimidazole derivatives. Thus, one of the important structural features of the benzimidazole-thiazole system is the presence of a chelate cavity. It is a potential center of complexation with me

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13

Arshadi, S., E. Vessally, L. Edjlali, R. Hosseinzadeh-Khanmiri, and E. Ghorbani-Kalhor. "N-Propargylamines: versatile building blocks in the construction of thiazole cores." Beilstein Journal of Organic Chemistry 13 (March 30, 2017): 625–38. http://dx.doi.org/10.3762/bjoc.13.61.

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Thiazoles and their hydrogenated analogues are not only key structural units in a wide variety of natural products but they also constitute important building blocks in medicinal chemistry. Therefore, the synthesis of these compounds using new protocols is always interesting. It is well known that N-propargylamines can undergo a number of cyclization reactions to produce various nitrogen-containing heterocycles. In this review, we highlight the most important developments on the synthesis of thiazole and its derivatives starting from N-propargylamines. This review will be helpful in the develo

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14

Goldstein, BM, JF Leary, BA Farley, VE Marquez, PC Levy, and PT Rowley. "Induction of HL60 cell differentiation by tiazofurin and its analogues: characterization and efficacy." Blood 78, no. 3 (1991): 593–98. http://dx.doi.org/10.1182/blood.v78.3.593.593.

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Abstract Among inducers of myeloid differentiation for leukemic cells, tiazofurin is of special interest because its mechanism of action is known; it inhibits inosine monophosphate dehydrogenase and thus decreases the guanine nucleotide pool. Reported here are three aspects of tiazofurin induction of myeloid differentiation in HL60 human acute promyelocytic leukemia cells. First, inductive efficacy was evaluated for analogues ara-tiazofurin, xylo-tiazofurin, and selenazofurin, for dinucleotide anabolites thiazole-4-carboxamide adenine dinucleotide (TAD) and selenazole-4-carboxamide adenine din

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15

Bayazeed, Abrar, Rua B. Alnoman, Kahdr Alatawi, et al. "Synthesis, molecular modeling and bioactivity of new bis-thiazole, thiazole-pyrazole, and thiazole-pyridine analogues." Journal of Saudi Chemical Society 27, no. 6 (2023): 101754. http://dx.doi.org/10.1016/j.jscs.2023.101754.

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16

Raut, Dattatraya G., Sandeep B. Patil, Prafulla B. Choudhari, et al. "POCl3 Mediated Syntheses, Pharmacological Evaluation and Molecular Docking Studies of Some Novel Benzofused Thiazole Derivatives as a Potential Antioxidant and Anti-inflammatory Agents." Current Chemical Biology 14, no. 1 (2020): 58–68. http://dx.doi.org/10.2174/2212796813666191118100520.

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Background: The present research work is focused on the development of alternative antioxidant and anti-inflammatory agents. The review of the literature reveals that many benzofused thiazole analogues have been used as lead molecules for the design and development of therapeutic agent, including anticancer, anti-inflammatory, antioxidant and antiviral. The synthesized benzofused thiazole derivatives are evaluated for in vitro antioxidant, anti-inflammatory activities and molecular docking study. Thus, the present research work aims to synthesize benzofused thiazole derivatives and to test the

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17

Kojic, Vesna, Milos Svircev, Sanja Djokic, et al. "Synthesis and antiproliferative activity of new thiazole hybrids with [3.3.0]furofuranone or tetrahydrofuran scaffolds." Journal of the Serbian Chemical Society, no. 00 (2023): 2. http://dx.doi.org/10.2298/jsc221130002k.

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New thiazole hybrids were synthesized and evaluated for their in vitro cytotoxicity against a panel of human malignant cell lines. The key steps in the synthesis of hybrids 3-7 involved the initial condensation of appropriate aldononitriles with cysteine ethyl ester hydrochloride, followed by subsequent treatment of resulting thiazolines with DBU to form the thiazole ring. Bioiso-steres 8 and 14 have been prepared after the stereoselective addition of 2-(tri-methylsilyl)thiazole to the hemiacetals obtained by periodate cleavage of terminal diol functionality in the suitably protected D-glucose

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18

Carbone, Anna, Barbara Parrino, Maria Cusimano, et al. "New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation." Marine Drugs 16, no. 8 (2018): 274. http://dx.doi.org/10.3390/md16080274.

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New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showing a selectivity against the staphylococcal strains. The most active derivatives elicited IC50 values against Staphylococcus aureus ATCC 25923, ranging from 0.40–2.03 µM. The new compounds showed a typical anti-virulence profile, being able to inhibit the biofilm formation without affecting the micr

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19

Chauhan, P. M. S., A. P. A. Crew, G. Jenkins, R. C. Storr, S. M. Walker, and M. Yelland. "Heterocyclic o-xylylenes: Thiazole, oxazole and imidazole analogues." Tetrahedron Letters 31, no. 10 (1990): 1487–90. http://dx.doi.org/10.1016/s0040-4039(00)88840-1.

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20

Lages, Marta A., M. Carmen de la Fuente, Lucía Ageitos, et al. "FrpA is the outer membrane piscibactin transporter in Vibrio anguillarum: structural elements in synthetic piscibactin analogues required for transport." JBIC Journal of Biological Inorganic Chemistry 27, no. 1 (2021): 133–42. http://dx.doi.org/10.1007/s00775-021-01916-1.

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AbstractPiscibactin (Pcb) is a labile siderophore widespread among Vibrionaceae. Its production is a major virulence factor of some fish pathogens such as Photobacterium damselae subsp. piscicida and Vibrio anguillarum. Although FrpA was previously suggested as the putative outer membrane transporter (OMT) for ferri-piscibactin, its role in piscibactin uptake was never demonstrated. In this work, we generated mutants of V. anguillarum defective in FrpA and analyzed their ability to use piscibactin as iron source. The results showed that inactivation of frpA completely disables piscibactin util

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21

Qazi, Syeda Uroos, Asia Naz, Aqeel Imran, and Jamshed Iqbal. "Urease inhibitory kinetics, molecular docking, SAR and ADME studies of imine analogues." New Journal of Chemistry 46, no. 7 (2022): 3512–20. http://dx.doi.org/10.1039/d1nj05123g.

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22

Staś, Monika, Małgorzata A. Broda, and Dawid Siodłak. "Thiazole–amino acids: influence of thiazole ring on conformational properties of amino acid residues." Amino Acids 53, no. 5 (2021): 673–86. http://dx.doi.org/10.1007/s00726-021-02974-0.

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Abstract Post-translational modified thiazole–amino acid (Xaa–Tzl) residues have been found in macrocyclic peptides (e.g., thiopeptides and cyanobactins), which mostly inhibit protein synthesis in Gram + bacteria. Conformational study of the series of model compounds containing this structural motif with alanine, dehydroalanine, dehydrobutyrine and dehydrophenylalanine were performed using DFT method in various environments. The solid-state crystal structure conformations of thiazole–amino acid residues retrieved from the Cambridge Structural Database were also analysed. The studied structural

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23

Zhang, Bao-Le, Li-Xing Song, Ya-Fei Li, et al. "Synthesis and biological evaluation of dehydroepiandrosterone-fused thiazole, imidazo[2,1-b]thiazole, pyridine steroidal analogues." Steroids 80 (February 2014): 92–101. http://dx.doi.org/10.1016/j.steroids.2013.12.003.

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24

Vasilev, Aleksey A., Meglena I. Kandinska, Stanimir S. Stoyanov, et al. "Halogen-containing thiazole orange analogues – new fluorogenic DNA stains." Beilstein Journal of Organic Chemistry 13 (December 28, 2017): 2902–14. http://dx.doi.org/10.3762/bjoc.13.283.

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Novel asymmetric monomeric monomethine cyanine dyes 5a–d, which are analogues of the commercial dsDNA fluorescence binder thiazole orange (TO), have been synthesized. The synthesis was achieved by using a simple, efficient and environmetally benign synthetic procedure to obtain these cationic dyes in good to excellent yields. Interactions of the new derivatives of TO with dsDNA have been investigated by absorption and fluorescence spectroscopy. The longest wavelength absorption bands in the UV–vis spectra of the target compounds are in the range of 509–519 nm and these are characterized by hig

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25

Sipos, Attila, Tímea Skaliczki, Sándor Berényi, and Sándor Antus. "Thiazole constrained analogues of the thevinones: synthesis and structure." Magnetic Resonance in Chemistry 47, no. 9 (2009): 801–7. http://dx.doi.org/10.1002/mrc.2447.

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26

Oliva, Paola, Valentina Onnis, Elisa Balboni, et al. "Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents." Molecules 25, no. 9 (2020): 2177. http://dx.doi.org/10.3390/molecules25092177.

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Induction of apoptosis is a common chemotherapeutic mechanism to kill cancer cells The thiazole system has been reported over the past decades as a building block for the preparation of anticancer agents. A novel series of 2-arylalkylamino-4-amino-5-(3′,4′,5′-trimethoxybenzoyl)-thiazole derivatives designed as dual inhibitors of tubulin and cyclin-dependent kinases (CDKs) were synthesized and evaluated for their antiproliferative activity in vitro against two cancer cell lines and, for selected highly active compounds, for interactions with tubulin and cyclin-dependent kinases and for cell cyc

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27

Kovács, Lajos, Pál Herczegh, Gyula Batta, and István Farkas. "Thiazole C-nucleosides. III. Synthesis of pyranose analogues of tiazofurin." Tetrahedron 47, no. 29 (1991): 5539–48. http://dx.doi.org/10.1016/s0040-4020(01)80985-6.

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28

Nußbaumer, Thomas, Claus Krieger, and Richard Neidlein. "21,23-Dithia-3,13-diazaporphycenes − Novel Aromatic Porphycene Analogues Incorporating Thiazole." European Journal of Organic Chemistry 2000, no. 13 (2000): 2449–57. http://dx.doi.org/10.1002/1099-0690(200007)2000:13<2449::aid-ejoc2449>3.0.co;2-f.

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29

Broudic, Nathan, Alexandra Pacheco-Benichou, Cécile Corbière, et al. "Novel Thiazole-Fused [4,5-g] or [5,4-g]Quinazolin-8-ones and Their Quinazoline Analogues: Synthesis and Biological Evaluation." Pharmaceuticals 17, no. 11 (2024): 1452. http://dx.doi.org/10.3390/ph17111452.

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Background/Objectives: In connection with previous work on V-shaped polycyclic thiazolo[5,4-f]quinazolin-9-one and [5,4-f]quinazoline derivatives that can modulate the activity of various kinases, the synthesis of straight thiazole-fused [4,5-g] or [5,4-g]quinazolin-8-ones and quinazoline derivatives hitherto undescribed was envisioned. Methods: An innovative protocol allowed to obtain the target structures. The synthesis of inverted thiazolo[4,5-h] and [5,4-h]quinazolin-8-one derivatives was also explored with the aim of comparing biological results. The compounds obtained were tested against

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30

Elnaggar, Dina H., Naglaa A. Abdel Hafez, Huda R. M. Rashdan, Nayera A. M. Abdelwahed, Hanem M. Awad, and Korany A. Ali. "Synthesis, Antimicrobial and Antitumor Evaluations of a New Class of Thiazoles Substituted on the Chromene Scaffold." Mini-Reviews in Medicinal Chemistry 19, no. 20 (2019): 1717–25. http://dx.doi.org/10.2174/1389557519666190722123422.

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Background & Objective: A new series of thiazoles substituted on the chromene scaffold were prepared by facial approaches starting from (E)-1-(2,3-Dihydrochromen-4-ylidene)thiosemicarbazide derivatives (2a,b). The thiosemicarbazides (2a,b) were reacted with a series of α-halo carbonyl compounds to give the corresponding rhodanine analogues and reacted also with C-acetyl-or Cethoxy- N-hydrazonoyl chlorides to afford the corresponding tri- and tetra-substituted hybrid hydrazinyl thiazole substituted chromenes. Methods: The newly synthesized compounds were screened for their in vitro antimicr

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31

Petrella, Stéphanie, Alexandra Aubry, Geneviève Janvier, et al. "Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors." Canadian Journal of Chemistry 94, no. 3 (2016): 240–50. http://dx.doi.org/10.1139/cjc-2015-0475.

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A recently discovered series of inhibitors of the ATPase function of bacterial type IIA topoisomerases featuring a carboxypyrrole component led us to attempt to replace this group with a potentially bioisosteric carboxypyrazole. Accordingly, synthetic pathways to 2-(4-(1H-pyrazole-5-carboxamido)piperidin-1-yl)thiazole-5-carboxylic acids or 2-(4-(N-methyl-1H-pyrazole-5-carboxamido)piperidin-1-yl)thiazole-5-carboxylic acids featuring an array of substituents on the pyrazole ring were explored. Unfortunately, none of the analogues made were effective on the ATPase function of Mycobacterium tuberc

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32

Wang, Shi-Meng, Gao-Feng Zha, K. P. Rakesh, et al. "Synthesis of benzo[d]thiazole-hydrazone analogues: molecular docking and SAR studies of potential H+/K+ ATPase inhibitors and anti-inflammatory agents." MedChemComm 8, no. 6 (2017): 1173–89. http://dx.doi.org/10.1039/c7md00111h.

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33

Seck, Pierre, David Thomae, Enrico Perspicace, Stéphanie Hesse, and Gilbert Kirsch. "Synthesis of new selenophene and thiazole analogues of the Tacrine series." Arkivoc 2012, no. 3 (2012): 431–41. http://dx.doi.org/10.3998/ark.5550190.0013.329.

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34

Veale, Clinton G. L., Kevin A. Lobb, Roya Zoraghi, et al. "Synthesis and MRSA PK inhibitory activity of thiazole containing deoxytopsentin analogues." Tetrahedron 70, no. 43 (2014): 7845–53. http://dx.doi.org/10.1016/j.tet.2014.09.007.

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35

Woods, Keith W., Richard W. McCroskey, Michael R. Michaelides, Carol K. Wada, Keren I. Hulkower, and Randy L. Bell. "Thiazole analogues of the NSAID indomethacin as selective COX-2 Inhibitors." Bioorganic & Medicinal Chemistry Letters 11, no. 10 (2001): 1325–28. http://dx.doi.org/10.1016/s0960-894x(01)00212-8.

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36

Parrino, Barbara, Alessandro Attanzio, Virginia Spanò, et al. "Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues." European Journal of Medicinal Chemistry 138 (September 2017): 371–83. http://dx.doi.org/10.1016/j.ejmech.2017.06.052.

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37

HUANG, L. F., J. W. KIM, L. BAUER, and G. DOSS. "ChemInform Abstract: Synthesis of 1,2,4-Triazole and Thiazole Analogues of Ketoconazole." ChemInform 28, no. 37 (2010): no. http://dx.doi.org/10.1002/chin.199737181.

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38

Zhang, Shengnan, Giorgia Croppi, Heng Hu, et al. "Bacillamide F, Extracted from Marine Bacillus atrophaeus C89, Preliminary Effects on Leukemia Cell Lines." Biology 11, no. 12 (2022): 1712. http://dx.doi.org/10.3390/biology11121712.

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Developing new treatments for leukemia is essential since current therapies often suffer from drug resistance and toxicity. Bacillamides are very promising, naturally occurring compounds with various bioactivities. In the present study, we investigated the use of bacillamide analogues, a new thiazole alkaloid bacillamide F that was isolated from marine Bacillus atrophaeus C89 associated with sponge Dysidea avara. The structure of the new compound bacillamide F with indolyl–thiazolyl–pyrrolidine ring was determined by high resolution mass spectrometry, secondary mass spectrometry, and nuclear m

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39

Satish, Kittur* Venkatesh Hanumanthachar Joshi. "A REVIEW ON FLURO-SUBSTITUED BENZOTHIOZOLES: A NEW PROFILE OF BIOLOGICAL ACTIVITIES." Indo American Journal of Pharmaceutical Sciences 05, no. 01 (2018): 130–34. https://doi.org/10.5281/zenodo.1136528.

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Benzothiazoles are an important class of bioactive & industrially important organic compounds recently; heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. Heterocyclic compounds analogues and their derivatives have attracted strong interest due to their biological and Pharmacological properties. Benzothiazoles are bicyclic ring system. A number of 2‐Aminobenzothiazoles have been studied as central muscle relaxants and found to interfere with glutamate neurotransmission in bioch

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Kesari, Chekrapani, Koteshwar Rao Rama, Khwajanezrabodin Sedighi, et al. "Synthesis of thiazole linked chalcones and their pyrimidine analogues as anticancer agents." Synthetic Communications 51, no. 9 (2021): 1406–16. http://dx.doi.org/10.1080/00397911.2021.1884262.

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Ibrahim, Muhammad Tukur, Adamu Uzairu, Gideon Adamu Shallangwa, and Sani Uba. "QSAR MODELLING AND DOCKING ANALYSIS OF SOME THIAZOLE ANALOGUES AS ⍺-GLUCOSIDASE INHIBITORS." Journal of Engineering and Exact Sciences 5, no. 3 (2019): 0257–70. http://dx.doi.org/10.18540/jcecvl5iss3pp0257-0270.

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van Muijlwijk-Koezen, Jacqueline E., Hendrik Timmerman, Roeland C. Vollinga, et al. "Thiazole and Thiadiazole Analogues as a Novel Class of Adenosine Receptor Antagonists." Journal of Medicinal Chemistry 44, no. 5 (2001): 749–62. http://dx.doi.org/10.1021/jm0003945.

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Lu, Qi, Qian Yu, Ya-Bo Zhu, et al. "Novel stilbene analogues containing thiazole moiety: Synthesis, biological evaluation and docking study." Journal of Molecular Structure 1180 (March 2019): 780–86. http://dx.doi.org/10.1016/j.molstruc.2018.12.068.

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Millan, David S., Rolf H. Prager, Catherine Brand, and Prue H. Hart. "The Synthesis and Activity of Oxazole and Thiazole Analogues of Urocanic Acid." Tetrahedron 56, no. 5 (2000): 811–16. http://dx.doi.org/10.1016/s0040-4020(00)00019-3.

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Nussbaumer, Thomas, Claus Krieger, and Richard Neidlein. "ChemInform Abstract: 21,23-Dithia-3,13-diazaporphycenes - Novel Aromatic Porphycene Analogues Incorporating Thiazole." ChemInform 32, no. 3 (2001): no. http://dx.doi.org/10.1002/chin.200103119.

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Venugopala, Katharigatta Narayanaswamy, Manjula Krishnappa, Susanta K. Nayak, et al. "Synthesis and antimosquito properties of 2,6-substituted benzo[d]thiazole and 2,4-substituted benzo[d]thiazole analogues against Anopheles arabiensis." European Journal of Medicinal Chemistry 65 (July 2013): 295–303. http://dx.doi.org/10.1016/j.ejmech.2013.04.061.

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Braga, Saulo Feheiberg Pinto, Nayara Cristina Fonseca, Jonas Pereira Ramos, Elaine Maria de Souza-Fagundes, and Renata Barbosa de Oliveira. "Synthesis and cytotoxicity evaluation of thiosemicarbazones and their thiazole derivatives." Brazilian Journal of Pharmaceutical Sciences 52, no. 2 (2016): 299–308. http://dx.doi.org/10.1590/s1984-82502016000200008.

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ABSTRACT The aims of this study were to synthesize a series of thiosemicarbazones and their thiazole derivatives, to investigate their cytotoxic activity against three human cancers and normal (Vero cells) cell lines, and to evaluate the pro-apoptotic potential of the most active compounds. Materials and Methods: The thiosemicarbazones were obtained by reacting an aromatic aldehyde with thiosemicarbazide (yield 71-96%), which were subjected to a cyclization with α-bromoacetophenone to yield the required thiazole heterocycles (yield 63-100%). All the synthesized compounds were screened at 50 µM

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Carbone, Anna, Stella Cascioferro, Barbara Parrino, et al. "Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation." Molecules 26, no. 1 (2020): 81. http://dx.doi.org/10.3390/molecules26010081.

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Anti-virulence strategy is currently considered a promising approach to overcome the global threat of the antibiotic resistance. Among different bacterial virulence factors, the biofilm formation is recognized as one of the most relevant. Considering the high and growing percentage of multi-drug resistant infections that are biofilm-mediated, new therapeutic agents capable of counteracting the formation of biofilms are urgently required. In this scenario, a new series of 18 thiazole derivatives was efficiently synthesized and evaluated for its ability to inhibit biofilm formation against the G

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Challacombe, Katherine, Simon J. Plackett, and G. Denis Meakins. "The use of protium and deuterium analogues in mechanistic studies of thiazole syntheses." Tetrahedron Letters 28, no. 46 (1987): 5767–68. http://dx.doi.org/10.1016/s0040-4039(00)96836-9.

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Kalaba, Predrag, Marija Ilić, Nilima Y. Aher, et al. "Structure–Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters." Journal of Medicinal Chemistry 63, no. 1 (2019): 391–417. http://dx.doi.org/10.1021/acs.jmedchem.9b01938.

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