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Journal articles on the topic 'Thiazolidone compound'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Varenichenko, S. A., A. V. Kharchenko, and O. K. Farat. "Synthesis and in silico ADMET profiling of novel 5-arylidene-2-(2,3,5,6,7,8-hexahydroacridin-4(1H)-ylidene)-1,3-thiazolidin-4-ones." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 6 (December 2023): 37–43. http://dx.doi.org/10.32434/0321-4095-2023-151-6-37-43.

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The corresponding thiazolidone derivative was synthesized with a good yield by the reaction of 1,2,3,4,5,6,7,8-octahydroacridine-4-carbonitrile with thioglycolic acid. It was found that this compound is present in DMSO in the form of two isomers, (2E)-2-(2,3,5,6,7,8-hexahydroacridin-4(1H)-ylidene)-1,3-thiazolidin-4-one and (2Z)-2-(2,3,5,6,7,8-hexahydroacridin-4(1H)-ylidene)-1,3-thiazolidin-4-one in a ratio of 9:1, respectively, whereas it is present only in the form of the E-isomer in chloroform. The corresponding 5-arylidene-2-(2,3,5,6,7,8-hexahydroacridin-4(1H)-ylidene)-1,3-thiazolidin-4-one

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2

Al-Abboodi1, Doaa Hashim, and Naeemah Al-lami. "NEW METHDOLOGY OF SYNTHESIS PYRAZOLO- THIAZOLO DERIVATIVES WITH STUDY ANTIMICROBAL ACTIVITIES." iraqi journal of market research and consumer protection 16, no. 1 (2024): 1–12. http://dx.doi.org/10.28936/jmracpc16.1.2024.(1).

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In this contribution, new derivatives of thiosemicarbazon, cyclic thiazolidinone, yilidine thiazolidinone, and parazolo-thiazole were synthesized, starting from the reaction of 2 -aminobenzothiazole with p-bromo phenacyl bromide to give the first step of 2(4-bromo phenyl) imidazole (2,1 -b) benzo thiazole (1). Compound (1) then was subjected under Viels Myer Haack to yield 3-carbaldehyde linking with imidazo-benzothiazol (2). Compound (2) condensed with thiosemicarbazide togivenewsynthesis of thiosemicarbazon derivative (3). Compound 4-Oxo-1,3-thiazolidine (4) was constituted from reacting com

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3

Allahyani, Mamdouh, Mazen Almehmadi, Osama Abdulaziz, et al. "Synthesis and in vitro antimicrobial screening of some 5-methyl-2-substituted phenyl-3- (phenylsulfonyl)thiazolidin-4-ones." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 04 (2024): 499. https://doi.org/10.59467/ijhc.2024.34.499.

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The synthesis of some new thiazolidine-sulfonamide derivatives was achieved in two steps. In the first step, appropriate aryl aldehyde reacted with benzene sulfonamide to yield N-arylidene benzene sulfonamide derivatives (1a-h). In the second step, compounds (1a-h) reacted with thiolactic acid to give the 5-methyl-2-substituted phenyl-3-(phenylsulfonyl) thiazolidin-4-one derivatives (2a-h). The compounds 2a-h were screened for their in vitro antimicrobial activity by agar disc diffusion method. The results showed that compounds 2b, 2c, and 2d exhibited anti-microbial activity against the teste

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4

Amit Kumar, Nitin Mittal, Mukesh Gupta, and Shikha Sharma. "Synthesis and Antibacterial Activity of Some Newer Thiazolidine-2,4-Dione Derivatives." Journal of Biomedical and Pharmaceutical Research 12, no. 4 (2023): 11–21. http://dx.doi.org/10.32553/jbpr.v12i4.1008.

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Thiazolidin-2,4-diones were intensively studied for its antidiabetic property in 1982. Thiazolidin-2,4-diones have also been demonstrated to possess different biological activity like anticancer, anti-HIV, antitumor, antimicrobial, antiviral and antiproliferative activity. 3-Benzoyl-5-(substituted benzylidine)-thiazolidin-2,4-diones and 3-p-Tolyl-5-(substituted benzylidine)-thiazolidin-2,4-diones have evaluated as structurally novel antimicrobials. A series of 5-[(SubstitutedPhenylamino)benzylidine]thiazolidine-2,4-dione derivatives 17(a-j) were synthesized by nucleophilic substitution reactio

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5

Kumar, Shiv, Nitin Kumar, Sushma Drabu, et al. "Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide Based Thiazolidinone Derivatives as Potent Antibacterial and Antifungal Agents." E-Journal of Chemistry 9, no. 4 (2012): 2155–65. http://dx.doi.org/10.1155/2012/857514.

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Twelve compounds belonging to series 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-[4-oxo-2-(substituted)phenyl-1,3-thiazolidin-3-yl]acetamide (5a-l) were synthesized. These compounds were evaluated for theirin-vitroantibacterial againstE. coli, S. aureus, K. pneumoniae, P. aeruginosa & antifungalactivity againstC. albicans, A. niger & A. flavusby cup-plate method. Structures of all the newly synthesized compounds were confirmed by elemental analysis,1H-NMR & FT-IR spectral data interpretation. Compounds 5d & 5h having p-nitrophenyl &p-trifluoromethylphenyl group respectively on

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6

Rosy P., Jacquline, Jebastin Sonia Jas M., Santhanalakshmi K, Venkat Kumar Shanmugam, and Prabhakaran A. "Identification of Potential Inhibitor Targeting InhA, Molecular Docking, ADMET, Molecular Dynamic Simulation and Antibacterial Activity of Thiazolidinone Derivatives: A Computational Approach." International Journal of Zoological Investigations 08, special issue (2022): 191–202. http://dx.doi.org/10.33745/ijzi.2022.v08i0s.024.

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This study was performed to examine molecular docking of newly synthesised thiazolidinone compounds and discover potential InhA inhibitors. MIC screening produced thiazolidinone derivatives for Staphylococcus aureus illness. KBr pellet FT-IR spectra were collected on a Thermo Nicolet AVATAR-330 spectrometer. Bruker obtained 400 MHz 1H spectra of all chemicals in DMSO-d6. Five 4 thiazolidinone derivatives:4-(4-oxo-2-phenylthiazolidin-3yl)amino)benzyl)oxazolidin-2-one(8), ((2-(4 chlorophenyl)-4oxothiazolidin-3yl)amino)benzyl)- oxazolidin-2-one(9), ((2-(4-fluorophenyl)-4-oxothiazolidin-3 yl)amino

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7

Perepelytsya, O. O., I. M. Yaremiy, K. P. Kupchanko, N. V. Panasenko, M. K. Bratenko, and M. V. Vovk. "Synthesis and hypoglycemic activity of derivatives of 4-((1,3-thiazolydine-5-yliden)methy)pyrazole-3-carbonic acid and its esters." Chernivtsi University Scientific Herald. Chemistry, no. 819 (2019): 37–44. http://dx.doi.org/10.31861/chem-2019-819-06.

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An effective preparative method of synthesis of a series of new (pyrazole-4-il)methylenethiazolidine structures has been elaborated. The structures are functionalized in the 3rd position by the carboxylate or carboxyle group and in the 3rd and 5th positions of the thiazolidine cycle – by the oxo-, thio- or iminogroups. The method involves condensation of 4-formylpyrazole-3-carbonic acids and their ethyl esters with a series of the substituted thiazolidines: 1,3-thiazolidine-2,4-dione, 4-thioxo-1,3-thiazolidine-2-one, 2-thioxo-1,3-thiazolidine-4-one and 2-imino-1,3-thiazolidine-4-one. A group o

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8

Kumar, Nitin, and Sanjay Sharma. "SYNTHESIS AND ANTICANCER ACTIVITY OF N-SUBSTITUTED INDOLE DERIVATIVES." INDIAN DRUGS 58, no. 12 (2022): 16–21. http://dx.doi.org/10.53879/id.58.12.12496.

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Thizolidine-2,4-dione (1), on reaction with p-fluorobenzaldehyde in the presence of piperidine and toluene, gives (Z)-5-(2-fluororobenzylidin)-thiazolidin-2,4-dione (2), which on reaction with indole and o-chlorobenzaldehyde in the presence of ethanol yielded final derivatives i.e (Z)-5-(4-fluororobenzylidene)-3-[(1H-indol-1-yl) (substituted phenyl) methyl] thiazolidine-2,4-dione (3a-3e). All the synthesized compounds were characterized by UV, FTIR, 1 H NMR, MASS spectroscopy and elemental analysis. These compounds were screened for their anticancer activity against MCF-7 human breast cancer c

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9

Nuriye, Ahmed, Hemant Yennawar, Kevin Cannon, and John Tierney. "Crystal structures of two thiazolidinone derivatives bearing a trichloromethyl substituent at the 2-position." Acta Crystallographica Section E Crystallographic Communications 74, no. 10 (2018): 1509–12. http://dx.doi.org/10.1107/s2056989018013257.

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The title compounds 2-trichloromethyl-3-phenyl-1,3-thiazolidin-4-one (C10H8Cl3NOS),1and 3-(4-chlorophenyl)-2-trichloromethyl-1,3-thiazolidin-4-one (C10H7Cl4NOS)2, are structurally related with one atom substitution difference in theparaposition of the benzene ring. In both structures, the thiazolidinone ring adopts an envelope conformation with the S atom as the flap. The dihedral angles between the rings [48.72 (11) in1and 48.42 (9)° in2] are very similar and the molecules are almost superimposable. In both crystal structures, C—H...O `head-to-tail' interactions between the chiral carbon atom

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10

da Silva Santos, Jonas, Joel Jones Junior, and Flavia M. da Silva. "1,3-Thiazolidin-4-ones: Biological Potential, History, Synthetic Development and Green Methodologies." Current Organic Synthesis 15, no. 8 (2018): 1109–23. http://dx.doi.org/10.2174/1570179415666180919125625.

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Background: We present here the synthesis of 1,3-thiazolidin-4-one (1) and its functionalised analogues, such as the classical isosteres, glitazone (1,3-thiazolidine-2,4-dione) (2), rhodanine (2-thioxo-1,3- thiazolidin-4-one) (3) and pseudothiohydantoin (2-imino-1,3-thiazolidin-4-one) (4) started in the midnineteenth century to the present day (1865-2018). Objective: The review focuses on the differences in the representation of the molecular structures discussed here over time since the first discussions about the structural theory by Kekulé, Couper and Butlerov. Moreover, advanced synthesis

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11

El-Rayyes, Ali, Roaa T. Mogharbel, Mohamed H. Abdel-Rhman, Mohamed A. Ismail, and Ehab Abdel-Latif. "Molecular geometry and biological activity of 2-(4-substituted-phenylimino)thiazolidin- 4-one compounds." Bulletin of the Chemical Society of Ethiopia 37, no. 5 (2023): 1275–86. http://dx.doi.org/10.4314/bcse.v37i5.18.

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ABSTRACT. A series of 2-(4-substituted-phenylimino)thiazolidin-4-one compounds was synthesized via heterocyclizing the corresponding N-aryl-2-chloroacetamides with ammonium thiocyanate. Their chemical structures were elucidated based on an extensive analysis of their spectroscopic data, including infrared, 1H NMR, 13C NMR, and mass analyses. The possible tautomeric forms of synthesized thiazolidine-4-ones were studied. The tautomerization equilibrium parameters, ΔH, ΔG, and Keq were calculated using the DFT/B3LYP methodology, where it has been indicated that the tautomeric form, phenylimino, i

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12

Kola, Satish Shamrao, Vishnu Nayak Badavath, Mohammad Idrees M. Siddique, Naqui Siddiqui, Chandrashekhar Devkate, and Syed Abrar Ahmed. "Microwave-assisted green synthesis and molecular docking study of some new 4-thiazolidinone derivatives as possible bioactive agents." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 03 (2024): 327. http://dx.doi.org/10.59467/ijhc.2024.34.327.

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We have developed an economical and environmentally friendly microwave-assisted efficient method for the synthesis of a series of new 4-oxo-thiazolidine derivatives (4a-d). The method involves microwave irradiated cyclocondensation reaction of Schiff bases (3a-d) and thioglycolic acid in drug master file (DMF). 4-oxo-thiazolidine derivatives (4a-d) was also synthe 4-Oxo-Thiazolidine derivatives were also synthesized by conventional heating procedures and consequence were Compared with Microwave assisted green method. The results suggest that microwave-assisted syntheses lead to higher yields w

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13

Rishipathak, Dinesh, Sushil Vaidya, and Shantanu Ghodke. "Synthesis and Evaluation of Anticonvulsant Activity of Some 5,5-Disubstituted-N3-[(2-aryl thiazolidine-4-one-3-yl)amino]hydantoins." Asian Journal of Chemistry 35, no. 3 (2023): 591–97. http://dx.doi.org/10.14233/ajchem.2023.27282.

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According to the World Health Organization, the majority of people with epilepsy who live in developing countries do not have access to high-quality treatment. Modern anticonvulsants are in high demand since the unwanted effects of those compounds already in use make therapy difficult. The synthesis of derivatives of 5,5-disubstituted-N3-[(2-aryl thiazolidine-4-one-3-yl)amino]hydantoins has been reported. The position N3 of the hydantoin nucleus was substituted with 4-thiazolidinone moiety containing aryl substituent at 2nd position with the goal of achieving the enhanced anticonvulsant effect

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14

Patel, Divyesh, Rahul Patel, Premlata Kumari, and Navin B. Patel. "Synthesis of s-Triazine-Based Thiazolidinones as Antimicrobial Agents." Zeitschrift für Naturforschung C 67, no. 3-4 (2012): 108–22. http://dx.doi.org/10.1515/znc-2012-3-402.

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5A novel series of thiazolidinone derivatives, namely 4-{4-dimethylamino-6-[4-oxo- 2-phenyl-5-(4-pyridin-2-yl-piperazin-1-ylmethyl)-thiazolidin-3-yl]-[1,3,5]-triazin-2-yloxy}- 1-methyl-1H-quinolin-2-ones, have been synthesized from the key intermediate 4-(4-amino- 6-dimethylamino-[1,3,5]-triazin-2-yloxy)-1-methyl-1H-quinolin-2-one (). Compound 5 was condensed with various aldehydes to give Schiff base derivatives, which after cyclization gave thiazolidinones that were linked with 1-pyridin-2-yl-piperazine to obtain the target compounds. The newly synthesized compounds were evaluated for their

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15

Hoàn, Dương Quốc. "REACTION OF SCHIFF BASES WITH THIOGLYCOLIC ACID: SYNTHESIS OF THIAZEPIN-1(2H)-ONE AND THIAZOLIDIN-4-ONE COMPOUNDS." Hue University Journal of Science: Natural Science 127, no. 1A (2018): 5. http://dx.doi.org/10.26459/hueuni-jns.v127i1a.4516.

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<p>Reaction of Schiff bases with thioglycolic acid was set up with Dean stark apparatus in toluene. The Schiff bases containing aniline derivatives <strong>1a</strong> and <strong>2a</strong> gave thiazolidin-4-one containing compounds<strong> 1b</strong> and <strong>2b</strong> only; 1-naphthyl amine gave a mixture of thiazolidin-4-one (<strong>3b)</strong> and thiazepin-1(2H)-one (<strong>3b’</strong>) containing compounds; 2-naphthyl amine (<strong>4a</strong>) gave and thiazepin-1(2H)-one containing c

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16

Vaughan, Keith, Hartford W. Manning, Marcus P. Merrin, and Donald L. Hooper. "Open chain nitrogen compounds. Part XIII. 1-Aryl-3-arylthiomethyl-3-methyltriazenes and 3-(arylazo)-1,3-thiazolidines." Canadian Journal of Chemistry 66, no. 10 (1988): 2487–91. http://dx.doi.org/10.1139/v88-391.

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Reaction of 3-acetoxymethyl-1-aryl-3-methyltriazenes with sodium thiophenolate or thiocresolate in anhydrous dimethylformamide affords a new series of 3-arylthiomethyltriazenes (2), Ar-S-CH2-NMe-N=N-Ar′. These triazenes are remarkably labile in aqueous buffer and may be good pro-drugs for the active metabolite of the antitumour dimethyltriazenes. The reaction of arenediazonium fluoroborates with 1,3-thiazolidine in aqueous acetone affords a new series of N-arylazo-1,3-thiazolidines (4); the arylazothiazolidines represent a new class of triazene in which the N3 nitrogen is incorporated into a h

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17

Parmar, Kokila A., and Sarju N. Parajapati. "Formation and Biological Evaluation of 4-Thiazolidinone Derivatives for their Pharmacological Activity." International Letters of Chemistry, Physics and Astronomy 61 (November 2015): 84–93. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.61.84.

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Thiazolidin-4-one is a versatile lead molecule for designing potential bioactive agents. An expeditious method for preparation of 4-thiazolidinones 7(a-h) are an important class of heterocycles, having potential biological importance due to their unique features. The process of convert of imine (Schiff’s base) to 4-thiazolidinone through an intermediate of THF mercapto acetic acid with anhydrous zinc chloride is important synthetic method for preparation of 4-thiazolidinone. The structures of the synthesized compounds were confirmed by IR, 1H-NMR, 13C NMR and Mass spectral studies. The compoun

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Parmar, Kokila A., and Sarju N. Parajapati. "Formation and Biological Evaluation of 4-Thiazolidinone Derivatives for their Pharmacological Activity." International Letters of Chemistry, Physics and Astronomy 61 (November 3, 2015): 84–93. http://dx.doi.org/10.56431/p-tuhnri.

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Thiazolidin-4-one is a versatile lead molecule for designing potential bioactive agents. An expeditious method for preparation of 4-thiazolidinones 7(a-h) are an important class of heterocycles, having potential biological importance due to their unique features. The process of convert of imine (Schiff’s base) to 4-thiazolidinone through an intermediate of THF mercapto acetic acid with anhydrous zinc chloride is important synthetic method for preparation of 4-thiazolidinone. The structures of the synthesized compounds were confirmed by IR, 1H-NMR, 13C NMR and Mass spectral studies. The compoun

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19

Mishchenko, Mariia, Sergiy Shtrygol, Danylo Kaminskyy, and Roman Lesyk. "Thiazole-Bearing 4-Thiazolidinones as New Anticonvulsant Agents." Scientia Pharmaceutica 88, no. 1 (2020): 16. http://dx.doi.org/10.3390/scipharm88010016.

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Here, we describe the synthesis and anticonvulsant activity of thiazole-bearing hybrids based on 2-imino-4-thiazolidinone and 2,4-dioxothiazolidine-5-carboxylic acid cores. The structure of target compounds was based on the following: (i) A combination of two thiazole cores; (ii) similarity to ralitolin’s structure; (iii) the compliance with structural requirements for the new anticonvulsants. Target compounds were synthesized via known approaches based on Knoenavegel reaction, alkylation reaction, and one-pot three-component reaction. Anticonvulsant properties of compounds were evaluated in t

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20

da Silva, Ivanildo Mangueira, João da Silva Filho, Priscila Brandão Gomes da Silva Santiago, et al. "Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/316082.

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Antibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. Using a disc diffusion method, antimicrobial activity w

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21

Sawant, Ramesh, Jyoti Wadekar, Rushikesh Ukirde, and Ganesh Barkade. "Synthesis, Molecular Docking and Anticancer Activity of Novel 1,3-Thiazolidin-4-Ones." Pharmaceutical Sciences 27, no. 3 (2020): 345–52. http://dx.doi.org/10.34172/ps.2020.95.

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Background: Cancer is a major cause of death all over the globe. Controlling cell division byinhibition of mitosis is the most successful clinical strategy for cancer treatment. The developmentof novel anticancer agents is the most important area in medicinal chemistry and drug discoveryresearch. Thiazolidine is the multifunctional nucleus which shows a number of pharmacologicalactivities like anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, antidiabetic,antihyperlipidemic and antiarthritic. Methods: In a present study series of 2-substituted-3-(1H-benzimidazole-2-yl)-thi

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22

Trotsko, Nazar, Adrian Bekier, Agata Paneth, Monika Wujec, and Katarzyna Dzitko. "Synthesis and In Vitro Anti-Toxoplasma gondii Activity of Novel Thiazolidin-4-one Derivatives." Molecules 24, no. 17 (2019): 3029. http://dx.doi.org/10.3390/molecules24173029.

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Recent findings on the biological activity of thiazolidin-4-ones and taking into account the lack of effective drugs used in the treatment of toxoplasmosis, their numerous side effects, as well as the problem of drug resistance of parasites prompted us to look for new agents. We designed and synthesized a series of new thiazolidin-4-one derivatives through a two-step reaction between 4-substituted thiosemicarbazides with hydroxybenzaldehydes followed by the treatment with ethyl bromoacetate; maleic anhydride and dimethyl acetylenedicarboxylate afforded target compounds. The thiazolidin-4-one d

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Gupta, Amit, Rajendra Singh, Pankaj K. Sonar, and Shailendra K. Saraf. "Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation." Biochemistry Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/8086762.

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A series of new 4-thiazolidinone derivatives was synthesized, characterized by spectral techniques, and screened for antimicrobial activity. All the compounds were evaluated against five Gram-positive bacteria, two Gram-negative bacteria, and two fungi, at concentrations of 50, 100, 200, 400, 800, and 1600 µg/mL, respectively. Minimum inhibitory concentrations of all the compounds were also determined and were found to be in the range of 100–400 µg/mL. All the compounds showed moderate-to-good antimicrobial activity. Compounds4a[2-(4-fluoro-phenyl)-3-(4-methyl-5,6,7,8-tetrahydro-quinazolin-2-y

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Yennawar, Hemant P., Lee J. Silverberg, Kevin Cannon, et al. "Crystal structures of two 1,3-thiazolidin-4-one derivatives featuring sulfide and sulfone functional groups." Acta Crystallographica Section E Crystallographic Communications 74, no. 12 (2018): 1695–99. http://dx.doi.org/10.1107/s2056989018015098.

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The crystal structures of two closely related compounds, 1-cyclohexyl-2-(2-nitrophenyl)-1,3-thiazolidin-4-one, C15H18N2O3S, (1) and 1-cyclohexyl-2-(2-nitrophenyl)-1,3-thiazolidin-4-one 1,1-dioxide, C15H18N2O5S, (2), are presented. These compounds are comprised of three types of rings: thiazolidinone, nitrophenyl and cyclohexyl. In both structures, the rings are close to mutually perpendicular, with interplanar dihedral angles greater than 80° in each case. The thiazolidinone rings in both structures exhibit envelope puckering with the S atom as flap and the cyclohexyl rings are in their expect

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Majed, Ahmed A., and Dawood S. Abid. "Synthesis of Some New 1,3,4- Oxadiazole Derivatives and Thiazolidine Derived from Cysteine and Evaluation their Anticancer (MCF7) Activity." Biomedicine and Chemical Sciences 1, no. 2 (2022): 83–87. http://dx.doi.org/10.48112/bcs.v1i2.109.

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The study focused on the preparation of oxadiazole derivatives containing thiazolidine. Thiazolidine firstly was prepared from the reaction of benzaldehyde with L-cysteine with a good yield and then it was reacted with acetic anhydride to prepare acetyl thiazolidine, then with ethanol in the presence of H2SO4, then steps were taken to prepare a thiazolidine hydrazide (A3), which was reacted with aromatic carboxylic acid in presence POCl3 or carbon disulphide and base KOH to obtain oxadiazole derivatives A4-8. These compounds characterized using FT-IR, NMR and Mass (EI) were diagnosed and the s

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S., K. Sahu, K. Mishra S., Banerjee M., K. Panda P. та K. Misro P. "Synthesis, Partition coefficient and antibacterial activity of 3' -aryl-6' -phenyl(substituted)-cis-5' α,6' -dihydrospiro[3H -indole- 3,4' -thiozolo( 5' ,1' -c )-isoxazolo-2-(1H)-ones]". Journal of Indian Chemical Society Vol. 83, Jul 2006 (2006): 725–27. https://doi.org/10.5281/zenodo.5825204.

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University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar-751 004, Orissa, India Department of Chemistry, Berhampur University, Berhampur-760 007, Orissa, India <em>E-mail:</em> tutu_kh@yahoo.com Fax : 91-0674-2581850 <em>Manuscript received 7 January 2005, revised 14 December 2005, accepted 4 April 2006</em> Condensation of isatin with primary aryl amines gave a series of Schiff bases (1) which on reaction with thioglycolic acid in 1,4-dioxane afforded the corresponding thiazolidones (2). Compound 2 on condensation with substituted benzaldehydes in anhydrous

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Aggarwal, Navidha, and Sandeep Jain. "A Synthetic Approach, Characterization and Biological Evaluation of Novel 5-(Arylidene)-2-(5-methyl-1,3,4-thiadiazol-2-ylimino)thiazolidin-4-one Derivatives." Asian Journal of Chemistry 33, no. 7 (2021): 1530–36. http://dx.doi.org/10.14233/ajchem.2021.23203.

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The extensive biological potential of thiazolidin-4-one and 1,3,4-thiadiazole moieties, the novel string of 5-(arylidene)-2-(5-methyl-1,3,4-thiadiazol-2-ylimino)thiazolidin-4-one has been synthesized and characterized. The synthesized derivatives were screened for antimicrobial potential using serial tube dilution method. The results showed that all the synthesized compounds have significant biological activity against the microorganisms being tested. The antimicrobial activity of the compounds TA2, TA3, TA4, TA9, TA10 and TA20 against the tested microbial strains was promising. Compound TA4 (

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K, Vandana, Anoob Kumar K. I, Jisha Prems, Vidhya K. M, and Lal Prasanth M. L. "Characterization & Invitro Antioxidant Activity of 1, 3, 4 Thiadiazole Derivatives of Thiazolidinone." Saudi Journal of Medical and Pharmaceutical Sciences 11, no. 06 (2025): 452–61. https://doi.org/10.36348/sjmps.2025.v11i06.002.

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In view of the considerable importance of thiadiazoles and thiazolidinones, which are the core structures in a variety of pharmaceuticals with a broad spectrum of biological activity. Synthesis of series of potential biological active 1, 3, 4 thiadiazole linked 4 thiazolidinone derivatives were obtained via a multistep synthesis sequence with a simple and convenient approach by using substituted benzoic acids, which are expected to possess enhanced antioxidant activity based on the literature survey reports. In the present study the initial compound, 5-phenyl-1, 3, 4-thiadiazol-2-amine was tre

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Desna, D. S., and Gurvinder Singh. "Molecular Docking-Based Synthesis of 5-(4-Aminobenzylidene)thiazolidine-2,4-Dione Derivatives as Anti-Inflammatory Agents." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 04 (2024): 505. https://doi.org/10.59467/ijhc.2024.34.505.

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In this work, we synthesized a series of 5 new thiazolidine-2,4-dione derivatives (5a-5j) through a four-step reaction procedure starting from thiazolidine-2,4-dioneMolecular docking studies were performed to identify potential compounds against peroxisome proliferated activated receptor PDB ID 5GTO. Synthesized compounds were characterized by physicochemical and spectral analysis including Fourier Transform Infrared Spectroscopy IHNMR 13C NMR Mass spectra. All the data were in agreement with the synthesized compounds. Further, the compounds were evaluated for their in vivo anti-inflammatory a

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30

Walmik, Prabhakar, Basavaraj S. Naraboli, Swathi B, and Somashekhar Ghanti. "DESIGN, SYNTHESIS OF BIOLOGICALLY ACTIVE HETEROCYCLES CONTAINING INDOL- THIAZOLYL- THIAZOLIDINONE DERIVATIVES." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 113. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.22199.

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Objective: The present study envisage a novel series of thiazole, indole and thiazolidine derivatives, namely, N-((5-Substituted-2-phenyl-1 H-indol-3-yl)methylene)-4,5,6,7-tetrahydro-5,7,-dimethylbenzo [d]thiazole-2-amine (4a-c), 2-(5-substituted-2-phenyl-1H-indol-3-yl)-3-(4,5,6,7- trimethylbenzo[d]thiazol-2-yl)-thiazolidin-4-one (5a-c) and 5-benzylidine-2-(5-substituted-2phenyl-1H-indol-3yl)-3-(4,5,6,7-tetrahydro-5,5,7- trimethylbenzo[d]thiazol-2-yl) thiazolidin-4-one (6a-c).Methods: All the newly synthesized compounds were characterized by infrared, 1H, 13C nuclear magnetic resonance and mas

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Hitesh, D. Patel, D. Mistry B., and R. Desai K. "Synthesis and antimicrobial studies of 4-oxo-thiazolidine derivatives." Journal of Indian Chemical Society Vol. 86, Mar 2009 (2009): 287–92. https://doi.org/10.5281/zenodo.5808883.

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Chemistry Department, Gujarat University, Ahmedabad-380 009, Gujarat, India Chemistry Department, B. K. M. Science College, Valsad-396 001, Gujarat, India Chemistry Department, South Gujarat University, Surat-395 007, Gujarat, India <em>E-mail </em>: hiteshl3chem@rediffmail.com <em>Manuscript received 12 March 2008, revised 20 October 2008, accepted 12 November 2008</em> Ethyl (4-chlorophenoxy)acetate (1) upon condensation with hydrazine hydrate gave 2-(4-chlorophenoxy)- acetohydrazide (2) which by condensation with aromatic aldehydes gave 2-(4-chlorophenoxy)-<em>N</em>-(substitutedbenzyl

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32

Karam, Nisreen H., and Alaa K. Shanshal. "Synthesis, Characterization and Study of Mesomorphic Behavior of New Bent and Liner Core Compounds Containing Heterocyclic." Ibn AL- Haitham Journal For Pure and Applied Science 30, no. 3 (2017): 195. http://dx.doi.org/10.30526/30.3.1615.

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We described herein the synthesized and characterized of new bent and liner core compounds containing thiazolidin-4-one ring[XI-XIII] and [XIV-XVI] respectively. These compounds synthesized by sequence reactions starting from reaction resorcinol or hydroquinone with chloracetyl chloride to yield compounds [I] and [II] ,then the later compounds reactant with 4-hydroxybenzylaldehyde to product dialdehyde compounds [III] and [IV] .The Schiff bases compounds[V-VII] and [VIII-X] synthesized from reaction the compound [III] or [IV] with different aromatic amines, while the bent and liner core mesoge

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Zivkovic, Marijana B., Ivana Z. Matic, Marko V. Rodic, et al. "Anticancer potential of new steroidal thiazolidin-4-one derivatives. Mechanisms of cytotoxic action and effects on angiogenesis in vitro." J Steroid Biochem Mol Biol Nov 174 (July 19, 2017): 72–85. https://doi.org/10.1016/j.jsbmb.2017.07.031.

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The synthesis and cytotoxic activities determination of new steroidal mono- and bis(thiazolidin-4-ones) <strong>4a</strong>–<strong>f</strong> and <strong>5a</strong>–<strong>f</strong> have been performed. Their anticancer action was also evaluated in comparison to previously synthesized and reported corresponding steroidal thiosemicarbazones. All compounds were obtained as stereoisomeric mixtures with different configuration (<em>E</em> or <em>Z</em>) in the hydrazone moiety at the C-3 position. After several consecutive crystallizations diastereomerically pure major (<em>E</em>)

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34

Ghafil, Amer, and Shaimaa Adnan. "Synthesis and Characterization of Heterocyclic Derivatives from 5-Aminotetrazole and Investigation of Their Biological Activities." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 01 (2024): 107. http://dx.doi.org/10.59467/ijhc.2024.34.107.

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This study included the synthesis of some new heterocyclic compounds starting with 5-aminotetrazole, which reacted with 2-hydroxy-4-methoxybenzaldehyde to get compound 1. Then, 1 was converted to a Schiff base (2) derivative by reacting 1 with 2-aminothiazole. Then, compound 2 was reacted with different compounds, namely alanine, 2-mercaptoacetic acid, 2-aminobenzoic acid, phthalic anhydride, and malic anhydride, leading to the heterocyclic products imidazolidine (3), thiazolidine (4), quinazoline (5), and oxazepane (6) derivatives, respectively. All these compounds are characterized by 13C-NM

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35

Begum, Kahkashan. "Synthesis and Evaluation of Some 2–Aryl–3–[Substituted Pyridin–2–Yl]-Amino/Methylamino Thiazolidin-4-Ones." Oriental Journal of Chemistry 34, no. 6 (2018): 3052–57. http://dx.doi.org/10.13005/ojc/340647.

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A series of compounds incorporating thiazolidinone moiety has been synthesized and screened for their antifungal activity. 2-Aryl-3-[substituted pyridin-2-yl]-amino/methylamino thiazolidin-4-ones have been synthesized by cyclocondensation of [substituted pyridin-2-yl]- araldehydehydrazone and N-Methyl [substituted pyridin-2-yl]-araldehydehydrazone with mercapto acetic acid in dioxane. The initial reactants required for the synthesis were obtained by refluxing 2-hydrazino substituted pyridine and 2-[N-methylhydrazino]-substituted pyridine with different substituted aldehydes. These newly synthe

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36

Farhan, Muthanna S., Tuka Hassan Abd-Elhussain, and Azhar Mahdi Jasim. "Synthesis and preliminary antimicrobial evaluation of new 7-amino-4-methyl-coumarin thiazolidinone conjugates." Pharmacia 71 (October 3, 2024): 1–6. http://dx.doi.org/10.3897/pharmacia.71.e131859.

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As a part of our ongoing project on the design and synthesis of new 4-thiazolidinone derivatives with antimicrobial activity, four new 4-thiazolidinone derivatives carrying bromo, nitro, methyl, and chloro groups on the benzene ring were synthesized by starting with the 7-amino-4-methylcoumarin moiety, linking coumarin with various phenyl isothiocynate to form the thiourea group, and then cyclizing the derivatives, characterized by IR and 1HNMR, and assayed in vitro for their antimicrobial activity against Gram positive and Gram negative bacteria and fungi. Overall, 2-(4-methyl-2-oxo-2H-chrome

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37

Farhan, Muthanna S., Tuka Hassan Abd-Elhussain, and Azhar Mahdi Jasim. "Synthesis and preliminary antimicrobial evaluation of new 7-amino-4-methyl-coumarin thiazolidinone conjugates." Pharmacia 71 (October 3, 2024): 1–6. https://doi.org/10.3897/pharmacia.71.e131859.

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As a part of our ongoing project on the design and synthesis of new 4-thiazolidinone derivatives with antimicrobial activity, four new 4-thiazolidinone derivatives carrying bromo, nitro, methyl, and chloro groups on the benzene ring were synthesized by starting with the 7-amino-4-methylcoumarin moiety, linking coumarin with various phenyl isothiocynate to form the thiourea group, and then cyclizing the derivatives, characterized by IR and 1HNMR, and assayed <i>in vitro</i> for their antimicrobial activity against Gram positive and Gram negative bacteria and fungi. Overall, 2-(4-methyl-2-oxo-2H

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38

Shukla, Karuna S., Shailendra Pandey, and Pooja A. Chawla. "Thiazolidine-2, 4-Diones as Non-Hepatotoxic Tri-action Drug Candidates: Design, Synthesis, Characterization, Biological Evaluation and Docking Studies." Letters in Organic Chemistry 17, no. 9 (2020): 659–79. http://dx.doi.org/10.2174/1570178617666191220142852.

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Thiazolidine-2, 4-diones and their derivatives are a well-established chemical class of compounds that express their pharmacological actions through insulin sensitization and enhanced glucose utilization in peripheral tissues. In the current research different approaches have been employed to synthesize thiazolidine-2, 4-dione derivatives and these synthesized compounds were chemically characterized for the establishment of their chemical structures. A series of thiazolidine-2, 4-dione (TZD) derivatives, Scheme 1 (3A-3V) 22 compounds, were synthesized and characterized by FT-IR, 1H NMR and mas

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39

Antonyuk, Volodymyr O., Nazar O. Manko, Lidiia V. Panchak, et al. "ENZYMATIC OXIDATION OF THIAZOLIDINES IN THE PRESENCE OF CYCLODEXTRINS: EVALUATION OF ANTIMICROBIAL ACTIVITY OF THE REACTANTS AND PRODUCTS." ACTA CHEMICA IASI 32, no. 2 (2024): 101–18. https://doi.org/10.47743/achi-2024-2-0007.

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The antimicrobial activity of native and H2O2-oxidized thiazolidine derivatives was investigated using horseradish peroxidase (EC 1.11.1.7) in a 33% aqueous solution of dimethylsulfoxide (DMSO). To increase the solubility of thiazolidines, 4% solutions of α- and β-cyclodextrins were used. The presence of α-CD increased the solubility of the studied compounds by 1.25-2 times, and β-CD by 1.66-2.87 times. Antimicrobial activity was assessed using the MTT test on cultures of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The native and oxidized forms of the compounds used in

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40

Rani, U. Usha, and A. Sreedevi. "Synthesis and Biological Evaluation of 3-(2-Benzoyl-4-chlorophenyl)-4H-spiro [indole-3,2-[1,3]thiazolidine]-2,4(1H)- dione Derivatives for Anti-tubercular and Antimicrobial Activities." Indian Journal Of Science And Technology 17, no. 20 (2024): 2101–9. http://dx.doi.org/10.17485/ijst/v17i20.1434.

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Objectives: To synthesize a new scaff fold of 3'-(2-Benzoyl-4-chlorophenyl)-4'H-spiro [indole-3,2'-[1,3] thiazolidine]-2,4'(1H)-dione derivatives and to assess the compounds for anti-tubercular and antimicrobial activities. Methods : A new series of 3'-(2-Benzoyl-4-chlorophenyl)-4'H-spiro [indole-3,2'- [1,3] thiazolidine]-2,4'(1H)-dione derivatives were prepared by synthesizing schiff’s bases followed by condensing schiff base with 2-mercaptopropanoic acid in the presence of zinc chloride. Synthesized compounds were characterized by IR, NMR and Mass spectral data. Their antimicrobial, antitube

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41

Önen-Bayram, F. Esra, Kerem Buran, Irem Durmaz, Barkin Berk, and Rengul Cetin-Atalay. "3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: a family of antiproliferative thiazolidines." MedChemComm 6, no. 1 (2015): 90–93. http://dx.doi.org/10.1039/c4md00306c.

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42

Drzał, Wiktoria, and Nazar Trotsko. "Review of Recent Advances in Thiazolidin-4-One Derivatives as Promising Antitubercular Agents (2021–Present)." Molecules 30, no. 10 (2025): 2201. https://doi.org/10.3390/molecules30102201.

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Tuberculosis (TB) remains one of the leading causes of mortality worldwide, exacerbated by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis strains. In the pursuit of novel therapeutic strategies, thiazolidin-4-one derivatives have gained significant attention due to their structural diversity and broad-spectrum biological activities. This review provides a comprehensive summary of recent advances (2021–present) in the synthesis, structure–activity relationship (SAR), and mechanisms of action of thiazolidin-4-one derivatives as promisin

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43

Baraskar, Archana Ratnakar, Ratnamala Sonawane, Yogesh Kshirsagar, and Sultan Pathan. "Synthesis and Characterization of 4-Thiazolidinones Derivatives with 6-Chlorobenzothiazole Moiety." Asian Journal of Organic & Medicinal Chemistry 8, no. 3 (2024): 35–38. http://dx.doi.org/10.14233/ajomc.2023.ajomc-p30726.

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The 4-thiazolidinone ring system is a fundamental structure which is present in a large variety of synthetic pharmaceuticals that has a wide range of potential biological effects. In this work, thioglycolic acid and 6-chloro-N-(substituted benzylidene)benzothiazol-2-amine were condensed in DMF solvent in the presence of ZnCl2 to obtain novel 3- (6-chlorobenzo[d]thiazol-2-yl)-2-(substituted aryl)thiazolidin-4-one derivatives. The structure of the synthesized compounds (3a-j) were confirmed using IR, 1H & 13C NMR and mass spectroscopy.

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44

Kumar, Harsh, Aakash Deep, and Rakesh Kumar Marwaha. "Chemical Synthesis, Mechanism of Action and Anticancer Potential of Medicinally Important Thiazolidin-2,4-dione Derivatives: A Review." Mini-Reviews in Medicinal Chemistry 19, no. 18 (2019): 1474–516. http://dx.doi.org/10.2174/1389557519666190513093618.

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Thiazolidin-2,4-dione (TZD) possessing an active methylene constitute an important chemical class of compounds for the development of new drugs. So, many scholars have synthesized these derivatives as target molecules and evaluated their biological potential. Currently, some of the TZDs are synthesized to treat human cancers stating high levels of PPARγ because it is expected that activation of PPARγ arbitrates their anticancer activity because PPARγ ligands have recently been established to affect differentiation, cell proliferation and apoptosis of different cell types. In the present review

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45

U, Usha Rani, and Sreedevi A. "Synthesis and Biological Evaluation of 3-(2-Benzoyl-4-chlorophenyl)-4H-spiro [indole-3,2-[1,3]thiazolidine]-2,4(1H)- dione Derivatives for Anti-tubercular and Antimicrobial Activities." Indian Journal of Science and Technology 17, no. 20 (2024): 2101–9. https://doi.org/10.17485/IJST/v17i20.1434.

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Abstract <strong>Objectives:</strong> To synthesize a new scaff fold of 3'-(2-Benzoyl-4-chlorophenyl)-4'H-spiro [indole-3,2'-[1,3] thiazolidine]-2,4'(1H)-dione derivatives and to assess the compounds for anti-tubercular and antimicrobial activities. <strong>Methods :</strong> A new series of 3'-(2-Benzoyl-4-chlorophenyl)-4'H-spiro [indole-3,2'- [1,3] thiazolidine]-2,4'(1H)-dione derivatives were prepared by synthesizing schiff’s bases followed by condensing schiff base with 2-mercaptopropanoic acid in the presence of zinc chloride. Synthesized compounds were characterized

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46

Ibrahim, Ramla Fayiq, and D. S. Abid. "Synthesis of Modern Amides Thiazolidine Derived From L-Cysteine and Investigation of Their Biological Effects on Cancer Cells." Journal of Kufa for Chemical Sciences 4, no. 1 (2024): 238–55. https://doi.org/10.36329/jkcm/2024/v4.i1.14690.

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The study included the preparation and characterization of new compounds called thiazolidine-4-carboximaide in three main steps. In the first step, compound (R) was reacted from the reaction of cysteine with different aromatic aldehydes. Then the compound (R)was reacted with acetic anhydride to prepare the compound (RA). The compound (RA) was reacted with the aromatic amine (phenyl hydrazine) and DCC,HOBT to obtain different amides-4-thiazolidine compounds. All compounds were diagnostic using organic description techniques, FT-IR,magnetic resonance spectroscopy, 1HNMR, and 13CNMR, mass spect

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47

Athraa J. Ali and Nisreen H. Karam. "Design of New V Shaped Thermotropic Liquid Crystals containing Heterocyclic." Ibn AL-Haitham Journal For Pure and Applied Sciences 36, no. 2 (2023): 251–58. http://dx.doi.org/10.30526/36.2.3046.

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The characterization and design of this study of new liquid crystals with a V shape compounds containing thiazolidine-2,4-dione and 1,3-phenylene as a core unite with mesophase properties were reported. Preparation and characterization of chloroacetic acid, water, and thiourea to produce thiazolidine-2,4-dione [I] in the presence of strong hydrochloric acid. The 4-hydreoxybenzaldehyde and n-alkyl bromide were reacted with potassium hydroxide to create the n-alkoxy benzaldehyde., then the compound [I] reacted with [II]n in presence of piperidine to produce compounds [III]n. Also, converted reso

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48

Naik, B. D., and K. R. Desai. "Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel Thiazolidinones." E-Journal of Chemistry 1, no. 5 (2004): 263–66. http://dx.doi.org/10.1155/2004/435147.

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As a target to synthesize various Thiazolidinone derivatives, 2-Amino-4-(coumarin-3-yl)-thiazole has been prepared by the reactions of 3-Bromo acetyl coumarin with thiourea. 3-Bromo acetyl coumarin was prepared from 3-Acetyl coumarin. The resulting compound 2-amino-4-(coumarin-3-yl)- thiazole was treated with different Aldehydes to give the intermediate Schiff base, which on further reaction with Thioglycolic acid and Thiolactic acid to give titled compound Thiazolidinone. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. The antibacterial activit

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49

Akhavan, Malihe, Naser Foroughifar, Hoda Pasdar, and Ahmadreza Bekhradnia. "Green Synthesis, Biological Activity Evaluation, and Molecular Docking Studies of Aryl Alkylidene 2, 4-thiazolidinedione and Rhodanine Derivatives as Antimicrobial Agents." Combinatorial Chemistry & High Throughput Screening 22, no. 10 (2020): 716–27. http://dx.doi.org/10.2174/1386207322666191127103122.

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Aim and Objective: The magic scaffolds rhodanine and thiazolidine are very important heterocyclic compounds in drug design and discovery. Those are important heterocyclic compounds that have attracted a great deal of attention due to the fact that they exhibit a variety of bioactivities including antibacterial, antifungal, antiviral, antimalarial, and anti-inflammatory activities. These agents often exhibit selective toxicity. The goal of this study was molecular docking, green and solvent-free efficient synthesis of a new series of hetero/aromatic substituted rhodanine and thiazolidine analog

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50

Jain, Amrita, and Sanjeev Kumar Sahu. "Thiazolidine derivatives and their pharmacological actions." E3S Web of Conferences 556 (2024): 01052. http://dx.doi.org/10.1051/e3sconf/202455601052.

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Heterocyclic compounds are the backbone of medicinal chemistry as they gave a prominent number of drugs in the clinical market. Thiazolidine, a five membered heterocyclic compound, possess multiple pharmacological activities viz. anti-microbial, anti-diabetic, anti-cancer, anti-inflammatory, analgesic, anti-convulsant and anti-HIV. Various derivatives of thiazolidine nucleus have been synthesized and screened for these pharmacological activities. The present review summarizes some of these studies that have been reported in the last two decades.

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