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Journal articles on the topic 'Thiazolopyrimidine'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Tolba, Mahmoud S., Mostafa Sayed, Shaban A. A. Abdel-Raheem, Taher A. Gaber, Adel M. Kamal El-Dean, and Mostafa Ahmed. "Synthesis and spectral characterization of some new thiazolopyrimidine derivatives." Current Chemistry Letters 10, no. 4 (2021): 471–78. http://dx.doi.org/10.5267/j.ccl.2021.4.004.

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Thiazolopyrimidnes are considered one of the most interesting classes in heterocyclic chemistry due to their pharmaceutical importance. Herein, we report the synthesis of some new heterocyclic compounds containing thiazolopyrimidine starting from compound (1) which was previously prepared in literature. The starting compound was allowed to react with different alkylating agents such as chloroacetone, chloroacetyl chloride, and phenacyl bromide to afford derivatives (2-4). Compound (5), benzylidene derivative, was obtained by the reaction of compound (2) with benzaldehyde while amino-dicarbonit

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2

El-Mahdy, Kamelia. "Synthesis of Some New Tetracyclic Pyrimidine Derivatives Using Exocyclic α,β-Unsaturated Ketone and Evaluation of Their Antitumor Activities". JOURNAL OF ADVANCES IN CHEMISTRY 12, № 8 (2016): 311–17. http://dx.doi.org/10.24297/jac.v12i8.2840.

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Thiazolopyrimidine 2 was obtained from the reaction of dihydropyrimidinone with chloroacetic acid and benzaldehyde. Thiazolopyrimidine 2 containing an α,β-unsaturated ketonic function [-CH=CH-CO-] has been used as a component of Michael addition with an equimolar amount of dinucleophiles to give a series of novel tetracyclic pyrimidine derivatives. Treatment of thiazolopyrimidine 2 with uracil, aminotriazole, cyanoacetic acid hydrazide, o-phenylenediamine or diaminopyridine afforded the corresponding pyridopyrimidine, triazolopyrimidine, pyrazolone, benzodiazepine and triazepine derivative, re

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3

El-Mahdy, Kamelia. "Synthesis of Some New Tetracyclic Pyrimidine Derivatives Using Exocyclic α,β-Unsaturated Ketone and Evaluation of Their Antitumor Activities". JOURNAL OF ADVANCES IN CHEMISTRY 4, № 1 (2008): 311–17. http://dx.doi.org/10.24297/jac.v4i1.960.

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Thiazolopyrimidine 2 was obtained from the reaction of dihydropyrimidinone with chloroacetic acid and benzaldehyde. Thiazolopyrimidine 2 containing an α,β-unsaturated ketonic function [-CH=CH-CO-] has been used as a component of Michael addition with an equimolar amount of dinucleophiles to give a series of novel tetracyclic pyrimidine derivatives. Treatment of thiazolopyrimidine 2 with uracil, aminotriazole, cyanoacetic acid hydrazide, o-phenylenediamine or diaminopyridine afforded the corresponding pyridopyrimidine, triazolopyrimidine, pyrazolone, benzodiazepine and triazepine derivative, re

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4

AGGARWAL, S., M. DEVGUN, R. NARANG, S. LAL, A. C. RANA, and R. GOYAL. "Thiazolopyrimidines: A Retrospective Study of Synthesis, Structure-Activity Relationship and Diverse Pharmacological Actions." Asian Journal of Chemistry 34, no. 3 (2022): 519–30. http://dx.doi.org/10.14233/ajchem.2022.23448.

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Thiazolopyrimidine is a nitrogen and sulphur containing heterocyclic aromatic molecule. The bicyclic compound is made by fusing two aromatic rings, thiazole and pyrimidine and replacing one carbon atom with nitrogen and sulphur. The current present work covers a wide range of methods for synthesizing thiazolopyrimidine and its derivatives using a variety of catalysts, solvent medium and microwave irradiation with a goal of achieving a high yield and rapid separation of the product. This article describes the evolution of thiazolopyrimidine as antimicrobial, antiviral, anti-Parkinson, anticance

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5

Rasovic, Aleksandar. "The interaction between 4-oxothiazolidine-2-ylidene thioamides and iodine: a regioselective two-component 4-oxothiazolidine-2-ylidene thioamide to thiazolo[3,2-c]pyrimidine transformation mediated by iodine." Journal of the Serbian Chemical Society, no. 00 (2025): 1. https://doi.org/10.2298/jsc231207001r.

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This study investigated the interaction between selected 4- oxothiazolidine-2-ylidene thioamides 2a-c and iodine in acetone. The interaction followed two main reaction pathways: (1) iodine-mediated cyclization resulting in the formation of thiazolopyrimidine 7, and (2) electrophilic iodine attack on the thioamide sulfur atom, producing a complex mixture of iodine adducts. Due to the equilibrium of Z/E isomerization being strongly shifted to the Z-isomer in polar solvents, only the thioamide (E)-2b successfully formed thiazolopyrimidine 7. The other two derivatives, (Z)-2a and (Z)-2c, followed

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6

Mousavi-Moghadam, Farah Sadat, and Mohammad Ali Ghasemzadeh. "Preparation and Characterization of FeCo2O4 Nanoparticles: A Robust and Reusable Nanocatalyst for the Synthesis of 3,4-Dihydropyrimidin- 2(1H)-thiones and Thiazolopyrimidines." Current Nanoscience 15, no. 6 (2019): 637–46. http://dx.doi.org/10.2174/1573413714666180808163714.

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Background:The present research describes a mild and efficient method for the synthesis of 3,4-dihydropyrimidine-2(1H)-thiones and thiazolopyrimidine via multi-component reactions using FeCo2O4 nanoparticles. It was found that FeCo2O4 nanoparticles act as a powerful and effective catalyst. The prepared catalyst was characterized by the various spectroscopic techniques.Objective:The three-component reaction of thiourea, aromatic aldehydes and ethyl acetoacetate was catalyzed by FeCo2O4 nanoparticles. Next, the prepared 3,4-dihydropyrimidin-2(1H)-thiones were applied for the preparation of thiaz

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7

Vasilkova, N. O., A. V. Nikulin, and A. P. Krivenko. "Synthesis and Structure of Thiazolopyrimidine Derivatives." Russian Journal of Organic Chemistry 56, no. 6 (2020): 990–93. http://dx.doi.org/10.1134/s1070428020060044.

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8

Mobinikhaledi, A., N. Forughifar, and F. Goodarzi. "Synthesis of Some Bicyclic Thiazolopyrimidine Derivatives." Phosphorus, Sulfur, and Silicon and the Related Elements 178, no. 12 (2003): 2539–43. http://dx.doi.org/10.1080/714040967.

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9

Banu, Noor Afshan, and V. Bheema Raju. "Ethyl 7-methyl-3-oxo-5-phenyl-2-(2,4,6-trimethoxybenzylidene)-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate." Acta Crystallographica Section E Structure Reports Online 68, no. 4 (2012): o1213. http://dx.doi.org/10.1107/s1600536812012354.

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In the title compound, C26H26N2O6S, the benzene ring is positioned axially to the thiazolopyrimidine ring and bisects it with a dihedral angle of 80.94 (7)°. The pyrimidine ring adopts a flattened boat conformation. In the crystal, pairs of bifurcated C—H...O hydrogen bonds link the molecules into chains along thecaxis.

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10

NAGARAJAIAH, H., I. M. KHAZI, and NOOR SHAHINA BEGUM. "Synthesis, characterization and biological evaluation of thiazolopyrimidine derivatives." Journal of Chemical Sciences 124, no. 4 (2012): 847–55. http://dx.doi.org/10.1007/s12039-012-0271-z.

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11

Piqani, Bruno, and Wei Zhang. "Synthesis of diverse dihydropyrimidine-related scaffolds by fluorous benzaldehyde-based Biginelli reaction and post-condensation modifications." Beilstein Journal of Organic Chemistry 7 (September 16, 2011): 1294–98. http://dx.doi.org/10.3762/bjoc.7.150.

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Dihydropyrimidinones and dihydropyrimidinethiones generated from the Biginelli reactions of perfluorooctanesulfonyl-attached benzaldehydes are used as common intermediates for post-condensation modifications such as cycloaddition, Liebeskind–Srogl reaction and Suzuki coupling to form biaryl-substituted dihydropyrimidinone, dihydropyrimidine, and thiazolopyrimidine compounds. The high efficiency of the diversity-oriented synthesis is achieved by conducting a multicomponent reaction for improved atom economy, under microwave heating for fast reaction, and with fluorous solid-phase extractions (F

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12

Selvam, T. Panneer, V. Karthik, P. Vijayaraj Kumar, and M. Ashraf Ali. "Design, synthesis, antinociceptive, and anti-inflammatory properties of thiazolopyrimidine derivatives." Toxicological & Environmental Chemistry 94, no. 7 (2012): 1247–58. http://dx.doi.org/10.1080/02772248.2012.703204.

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13

Yavari, Issa, Mahniya Hojati, Leila Azad, and Mohammad Halvagar. "A Synthesis of Spirocyclic Oxazinoisoquinolines and Oxazinoquinolines Bearing Thiazolopyrimidine Moieties." Synlett 29, no. 08 (2018): 1024–27. http://dx.doi.org/10.1055/s-0037-1609302.

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The reaction of isoquinoline or quinoline with dialkyl acetylenedicarboxylates in the presence of alkyl 2-{3,5-dioxo-5H-thiazolo[3,2-a]pyrimidin-2(3H)-ylidene}acetates (generated in situ from acetylenedicarboxylates and 2-thiouracils) led to dialkyl 2-(2-alkoxy-2-oxoethylidene)-5-oxo-2H,5H,11b′H-spiro{thiazolo[3,2-a]pyrimidine-3,2′-[1,3]oxazino[2,3-a]isoquinoline}-3′,4′-dicarboxylates or dialkyl 2-(2-alkoxy-2-oxoethylidene)-5-oxo-2H,4a′H,5H-spiro{thiazolo[3,2-a]pyrimidine-3,2′-[1,3]oxazino[3,2-a]quinoline}-1′,2′-dicarboxylates in good yields. The structure of the target compounds was confirmed

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14

El-Seadawy, Nermin. "SYNTHESIS, REACTIONS AND ANTITUMOR EVALUATION OF SOME POLYCONDENSED THIAZOLOPYRIMIDINE DERIVATIVES." Al-Azhar Journal of Pharmaceutical Sciences 45, no. 1 (2012): 352–64. http://dx.doi.org/10.21608/ajps.2012.7247.

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15

Kashyap, Shiv Jee, Pramod Kumar Sharma, Vipin Kumar Garg, Rupesh Dudhe, and Nitin Kumar. "ChemInform Abstract: Synthesis and Various Biological Potentials of Thiazolopyrimidine Derivatives." ChemInform 43, no. 9 (2012): no. http://dx.doi.org/10.1002/chin.201209270.

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16

Nagarajaiah, H., I. M. Khazi, and Noor Shahina Begum. "ChemInform Abstract: Synthesis, Characterization and Biological Evaluation of Thiazolopyrimidine Derivatives." ChemInform 44, no. 2 (2013): no. http://dx.doi.org/10.1002/chin.201302149.

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17

Zhang, Hengxi, Carlos Modenutti, Yelha Phani Kumar Nekkanti, et al. "Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin." ACS Chemical Biology 17, no. 10 (2022): 2728–33. https://doi.org/10.5281/zenodo.8425350.

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Langerin is a mammalian C-type lectin expressed on Langerhans cells in the skin. As an innate immune cell receptor, Langerin is involved in coordinating innate and adaptive immune responses against various incoming threats. We have previously reported a series of thiazolopyrimidines as murine Langerin ligands. Prompted by the observation that its human homologue exhibits different binding specificities for these small molecules, we report here our investigations to define their exact binding site. By using structural comparison and molecular dynamics simulations, we showed that the nonconserve

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18

Amr, Abd El-Galil E., Mohamed A. Al-Omar, and Mohamed M. Abdalla. "A Potent Cyclooxygenase-2 Inhibitor for Synthesized Pyrimidine and Thiazolopyrimidine Derivatives." International Journal of Pharmacology 12, no. 2 (2016): 86–91. http://dx.doi.org/10.3923/ijp.2016.86.91.

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19

Aly, Aly A. "A Facile Synthesis and Heteroannulation of Thiazolopyrimidine and Related Heterocyclic Systems." Journal of Chemical Research 2007, no. 9 (2007): 552–56. http://dx.doi.org/10.3184/030823407x248621.

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Reaction of pyrimidinylacetic acid 2 with different electrophilic and nucleophilic reagents gave annulated pyrimidine derivatives 3–11, respectively. Compound 3 ([7-(dibenzothien-2-yl)-5-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]-pyrimidin-6-yl]acetic acid) was transformed to pyrimidinylacetyl azide 12, which upon heterocyclisation with active methylene compounds, acidic and basic reagents furnished functionally substituted heteroaromatic compounds 13–21, respectively. The structures of the synthesised derivatives were elucidated by elemental and spectral analyses.

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20

Larson, S. B., J. D. Anderson, H. B. Cottam, and R. K. Robins. "Structure of the sodium salt of a thiazolopyrimidine, a guanine analog." Acta Crystallographica Section C Crystal Structure Communications 45, no. 7 (1989): 1073–76. http://dx.doi.org/10.1107/s0108270188013757.

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21

Hou, Zhaohui, Ningbo Zhou, Binhong He, Ying Yang, and Xianyong Yu. "Study on the interaction between thiazolopyrimidine analogues and bovine serum albumin." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 79, no. 5 (2011): 1931–35. http://dx.doi.org/10.1016/j.saa.2011.05.093.

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22

Shashi, R., N. L. Prasad, and Noor Shahina Begum. "Synthesis and Crystal Structure of Thiazolopyrimidine Derivatives: Insights into Weak Interactions." Crystallography Reports 65, no. 7 (2020): 1161–68. http://dx.doi.org/10.1134/s1063774520070202.

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23

Gjorgieva Ackova, Darinka, Jelena Kotur-Stevuljevic, Chandra Bhushan Mishra, Pratibha Mehta Luthra, and Luciano Saso. "Antioxidant Properties of Synthesized Bicyclic Thiazolopyrimidine Derivatives as Possible Therapeutic Agents." Applied Sciences 9, no. 1 (2018): 113. http://dx.doi.org/10.3390/app9010113.

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Oxidant/antioxidant imbalance in the body has been implicated as one of the pathophysiological mechanisms leading to disease development. Therefore, we searched for a good antioxidant candidate that can be used as a therapeutic agent alone or in combination with other reported drugs. Earlier, we reported the A2A receptor antagonist properties of 7-Imino-3-substituted-2-thioxo-3,7-dihydro-2H-thiazolo[4,5-d]pyrimidin-6-yl)-urea derivatives (compounds 1–12) and the neuroprotective effect of compound 2. Therefore, in the present work, the antioxidant potential of compounds 1–12 was studied. Compou

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24

Aly, A. A. "A facile synthesis and heteroannulation of thiazolopyrimidine and related heterocyclic systems." Journal of Heterocyclic Chemistry 45, no. 4 (2008): 993–98. http://dx.doi.org/10.1002/jhet.5570450408.

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25

Abozeed, Amina, Mahmoud S. Tolba, Mostafa Sayed, Ahmed F. Al-Hossainy, and Osama Younis. "TD-DFT calculations and optical properties of a luminescent thiazolopyrimidine compound with different emission colors and uncommon blue shift upon aggregation." Journal of Applied Physics 133, no. 3 (2023): 033101. http://dx.doi.org/10.1063/5.0128280.

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A thin film of 7-oxo-thiazolopyrimidine-3,8-dicarbonitrile derivative [7-ThPyDi]TF was prepared using a spin coating technique. The surface morphology and molecular structure are studied using various techniques such as XRD, FTIR, and scanning electron microscope (SEM). Moreover, the quantum chemical calculations were carried out through time-dependent density functional theory (TD-DFT) to investigate some reactivity descriptors such as softness and electronegativity. Also, Au/[7-ThPyDi]TF/p-Si/Al heterojunction diodes were fabricated. It was revealed that the energy bandgap value of [7-ThPyDi

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26

Kotaiah, Y., N. Hari Krishna, K. Naga Raju, C. V. Rao, S. B. Jonnalagadda, and Suresh Maddila. "Synthesis and Biological Evaluation of Novel Isopropyl 2-thiazolopyrimidine-6-carboxylate Derivatives." Journal of the Korean Chemical Society 56, no. 1 (2012): 68–73. http://dx.doi.org/10.5012/jkcs.2012.56.1.068.

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27

Attaby, Fawzy A., and Sanaa M. Eldin. "Synthesis of Pyrimidine, Thiazolopyrimidine, Pyrimidotriazine and Triazolopyrimidine Derivatives and their Biological Evaluation." Zeitschrift für Naturforschung B 54, no. 6 (1999): 788–98. http://dx.doi.org/10.1515/znb-1999-0614.

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Pyrimidin-4-one-2-thione (3) was synthesized via the reaction of thiourea (1) with ethyl benzoylacetate (2) and was taken as a starting material for the present study via its reactions with the halogen-containing reagents 6a-d and lOa-c to give the corresponding thiazolopyrimidines 8, 9 and 12a-c. The 2-hydrazino derivatives 5 were synthesized either via the reaction of 3 or 4 with hydrazine hydrate. Compound 5 reacted with 6a-c and lOa-c to give the corresponding pyrimidotriazines 17a-c and 19 respectively. Also, compound 5 reacted with the active methylene-containing reagents 13 and 2a,b to

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28

Patel, Navin B., Amit C. Purohit, and Dhanji Rajani. "Newer thiazolopyrimidine-based sulfonamides clubbed with benzothiazole moiety: synthesis and biological evaluation." Medicinal Chemistry Research 23, no. 11 (2014): 4789–802. http://dx.doi.org/10.1007/s00044-014-1052-7.

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29

Basiony, Ebtesam A., Allam A. Hassan, Zahra M. Al-Amshany, et al. "Synthesis and Cytotoxic Activity of New Thiazolopyrimidine Sugar Hydrazones and Their Derived Acyclic Nucleoside Analogues." Molecules 25, no. 2 (2020): 399. http://dx.doi.org/10.3390/molecules25020399.

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New thienyl- or chlorophenyl-substituted thiazolopyrimidine derivatives and their derived sugar hydrazones incorporating acyclic d-galactosyl or d-xylosyl sugar moieties in addition to their per-O-acetylated derivatives were synthesized. Heterocyclization of the formed sugar hydrazones afforded the derived acyclic nucleoside analogues possessing the 1,3,4-oxadiazoline as modified nucleobase via acetylation followed by the cyclization process. The cytotoxic activity of the synthesized compounds was studied against human breast cancer MCF7 and MDA-MB-231 cell lines as well as human colorectal ca

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30

Flefel, E. E., M. A. Salama, M. El-Shahat, M. A. El-Hashash, and A. F. El-Farargy. "A Novel Synthesis of Some New Pyrimidine and Thiazolopyrimidine Derivatives for Anticancer Evaluation." Phosphorus, Sulfur, and Silicon and the Related Elements 182, no. 8 (2007): 1739–56. http://dx.doi.org/10.1080/10426500701313912.

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31

Gupta, Richa, and Ram Pal Chaudhary. "Synthesis, spectroscopic characterization and DFT studies on the novel indeno-thiazolopyrimidine heterocyclic system." Journal of Sulfur Chemistry 35, no. 1 (2013): 86–97. http://dx.doi.org/10.1080/17415993.2013.801477.

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32

Sharma, Mani, Monica Gupta, Divya Singh, Manoj Kumar, and Punit Kaur. "Synthesis, Evaluation and Molecular Docking of Thiazolopyrimidine Derivatives as Dipeptidyl Peptidase IV Inhibitors." Chemical Biology & Drug Design 80, no. 6 (2012): 918–28. http://dx.doi.org/10.1111/cbdd.12041.

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33

Krishnamurthy, M. S., and Noor Shahina Begum. "Crystal structure of ethyl 2-cyano-3-[(1-ethoxyethylidene)amino]-5-(3-methoxyphenyl)-7-methyl-5H-1,3-thiazolo[3,2-a]pyrimidine-6-carboxylate." Acta Crystallographica Section E Crystallographic Communications 71, no. 4 (2015): o256—o257. http://dx.doi.org/10.1107/s2056989015005241.

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In the title compound, C22H24N4O4S, the central pyrimidine ring adopts a sofa conformation with the ring-junction N atom displaced by 0.2358 (6) Å from the mean plane of the remaining ring atoms. The 3-methoxyphenyl ring, at the chiral C atom opposite the other N atom, is positioned axially and is inclined to the thiazolopyrimidine ring with a dihedral angle of 83.88 (7)°. The thiazole ring is essentially planar (r.m.s. deviation = 0.0034 Å). In the crystal, pairs of weak C—H...O hydrogen bonds link molecules related by twofold rotation axes to formR22(8) rings, which in turn are linked by wea

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34

Gomes, Ligia R., John Nicolson Low, Fernando Cagide, and Fernanda Borges. "Crystal structures of two 6-(2-hydroxybenzoyl)-5H-thiazolo[3,2-a]pyrimidin-5-ones." Acta Crystallographica Section E Crystallographic Communications 71, no. 7 (2015): 766–71. http://dx.doi.org/10.1107/s2056989015011044.

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The title compounds, 6-(2-hydroxybenzyl)-5H-thiazolo[3,2-a]pyrimidin-5-one, C13H8N2O3S, (1), and 6-(2-hydroxybenzyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one, C14H10N2O3S, (2), were synthesized when a chromone-3-carboxylic acid, activated with (benzotriazol-1-yloxy)tripyrrolidinylphosphonium hexafluoridophosphate (PyBOP), was reacted with a primary heteromamine. Instead of the expected amidation, the unusual title thiazolopyrimidine-5-one derivatives were obtained serendipitously and a mechanism of formation is proposed. Both compounds present an intramolecular O—H...O hydrogen bond, which g

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35

Baxter, Andrew, Anne Cooper, Elizabeth Kinchin, Kerry Moakes, John Unitt, and Alan Wallace. "Hit-to-Lead studies: The discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists." Bioorganic & Medicinal Chemistry Letters 16, no. 4 (2006): 960–63. http://dx.doi.org/10.1016/j.bmcl.2005.10.091.

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36

Istanbullu, Huseyin, Gulsah Bayraktar, Hasan Akbaba, et al. "Design, synthesis, and in vitro biological evaluation of novel thiazolopyrimidine derivatives as antileishmanial compounds." Archiv der Pharmazie 353, no. 8 (2020): 1900325. http://dx.doi.org/10.1002/ardp.201900325.

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37

Attaby, Fawzy A., and Sanaa M. Eldin. "ChemInform Abstract: Synthesis of Pyrimidine, Thiazolopyrimidine, Pyrimidotriazine, and Triazolopyrimidine Derivatives and Their Biological Evaluation." ChemInform 30, no. 45 (2010): no. http://dx.doi.org/10.1002/chin.199945186.

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38

Severina, Hanna I., Olga O. Skupa, Natalya I. Voloshchuk, Marharyta M. Suleiman, and Victoriya A. Georgiyants. "Synthesis and anticonvulsant activity of 6-methyl-2-((2-oxo-2-arylethyl)thio)pyrimidin-4(3 H)-one derivatives and products of their cyclization." Pharmacia 66, no. (3) (2019): 141–46. https://doi.org/10.3897/pharmacia.66.e38137.

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The alkylation of 6-methyl-2-thioxo-2,3-dihydro-1H-pyrimidine-4-one phenacyl bromides under different conditions was investigated. It was found that during the reaction in the medium of DMF/K<sub>2</sub>CO<sub>3</sub> a mixture of 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one and 3-hydroxy-3-aryl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-5-one was formed. The holding of the resulting mixture in the concentrated sulphuric acid leads to the formation of cyclization products - derivatives of 3-aryl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one with high yields. Individual S-alkylat

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39

Nagarajaiah, H., Nikhath Fathima, and Noor Shahina Begum. "Methyl 2-(2-bromobenzylidene)-5-(4-hydroxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-1,3-thiazolo[3,2-a]pyrimidine-6-carboxylate." Acta Crystallographica Section E Structure Reports Online 68, no. 4 (2012): o1257—o1258. http://dx.doi.org/10.1107/s1600536812013311.

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In the title compound, C22H17BrN2O4S, the central dihydropyrimidine ring, with a chiral C atom, is significantly puckered and adopts a half-chair conformation with the chiral C atom displaced from the mean plane of the remaining ring atoms by 0.305 (6) Å. The hydroxy-phenyl ring is positioned axially to the pyrimidine ring and almost bisects it, the dihedral angle between the mean-planes of the two rings being 89.78 (12)°. The methoxycarbonyl group is disordered over two sites with an occupancy ratio of 0.568 (5):0.432 (5), resulting in a major and a minor conformer. In the crystal, O—H...N an

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40

Rahman, A. A. H. Abdel, A. K. F. Shaban, I. F. Nassar, et al. "Synthesis and Anticancer Activity of New Pyrimidine and Oxadiazole Acyclic Nucleoside Analogs and Thiazolopyrimidine Derivatives." Russian Journal of General Chemistry 91, no. 10 (2021): 2086–94. http://dx.doi.org/10.1134/s1070363221100261.

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Geist, Julie G, Susan Lauw, Victoria Illarionova, et al. "Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum." ChemMedChem 5, no. 7 (2010): 1092–101. http://dx.doi.org/10.1002/cmdc.201000083.

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Luke, Richard W. A., Peter Ballard, David Buttar, et al. "Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo." Bioorganic & Medicinal Chemistry Letters 19, no. 23 (2009): 6670–74. http://dx.doi.org/10.1016/j.bmcl.2009.10.001.

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Batool, Iram, Aamer Saeed, Irfan Zia Qureshi, Saima Kalsoom, and Ayesha Razzaq. "Synthesis, molecular docking and biological evaluation of new thiazolopyrimidine carboxylates as potential antidiabetic and antibacterial agents." Research on Chemical Intermediates 42, no. 2 (2015): 1139–63. http://dx.doi.org/10.1007/s11164-015-2078-2.

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Youssef, Mohamed M., and Mahmoud A. Amin. "Microwave Assisted Synthesis of Some New Thiazolopyrimidine, Thiazolodipyrimidine and Thiazolopyrimidothiazolopyrimidine Derivatives with Potential Antioxidant and Antimicrobial Activity." Molecules 17, no. 8 (2012): 9652–67. http://dx.doi.org/10.3390/molecules17089652.

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Alzahrani, Hayat E., Ahmed M. Fouda, and Ayman M. S. Youssef. "Selective cyclization of S‐substituted pyrimidinethione: Synthesis and antimicrobial evaluation of novel polysubstituted thiazolopyrimidine and thiazolodipyrimidine derivatives." Journal of the Chinese Chemical Society 67, no. 5 (2019): 838–55. http://dx.doi.org/10.1002/jccs.201900199.

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Hammam, Abou El-Fotooh G., Mohie A. Sharaf, and Naglaa A. Abd El-Hafez. "ChemInform Abstract: Synthesis and Anticancer Activity of Pyridine and Thiazolopyrimidine Derivatives Using 1-Ethylpiperidone as a Synthon." ChemInform 32, no. 26 (2010): no. http://dx.doi.org/10.1002/chin.200126151.

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Banoth, Sonyanaik, Sakram Boda, Shyam Perugu, Saikrishna Balabadra, and Vijjulatha Manga. "Design, synthesis, biological evaluation and in silico molecular docking studies of novel benzochromeno[2,3-d]thiazolopyrimidine derivatives." Research on Chemical Intermediates 44, no. 3 (2017): 1833–46. http://dx.doi.org/10.1007/s11164-017-3201-3.

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Istanbullu, Huseyin, Gulsah Bayraktar, Gulsah Karakaya, et al. "Design, synthesis, in vitro – In vivo biological evaluation of novel thiazolopyrimidine compounds as antileishmanial agent with PTR1 inhibition." European Journal of Medicinal Chemistry 247 (February 2023): 115049. http://dx.doi.org/10.1016/j.ejmech.2022.115049.

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Mohamed, Salwa F., Eman M. Flefel, Abd El-Galil E. Amr, and Dina N. Abd El-Shafy. "Anti-HSV-1 activity and mechanism of action of some new synthesized substituted pyrimidine, thiopyrimidine and thiazolopyrimidine derivatives." European Journal of Medicinal Chemistry 45, no. 4 (2010): 1494–501. http://dx.doi.org/10.1016/j.ejmech.2009.12.057.

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