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Journal articles on the topic 'Thiazolyl substituted Schiff's bases'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

R., S. Talegaonkar, and S. Burghate A. "pH-metric studies on formation constants of the complexes of substituted thiazolyl Schiff's bases with some lanthanide metal ions." Journal of Indian Chemical Society Vol. 89, Nov 2012 (2012): 1585–89. https://doi.org/10.5281/zenodo.5771932.

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Post Graduate Department of Chemistry, Shri Shivaji Science College, Amravati-444 603, Maharashtra, India <em>E-mail</em> : rupaliyeotikar@gmail.com Manuscript received 22 September 2011, revised 08 February 2012, accepted 09 February 2012 The stability constants of the complexes of La<sup>llI</sup>, Pr<sup>lll</sup> and Sm<sup>III</sup> with 2-[3-(4-methoxy-phenyl)-1-(4-phenyl-thiazol-2-yllmino )-allyl]-4-methyl phenol, 2-[3-pheny 1-1-( 4-pheny 1-thiazol-2-ylim ino )-allyl]-4-methy 1-phenol and 2-[3-( 4- chlorophenyl)-1-(4-phenyl-thiazol-2-ylimino)-allyl]-4-methyl-phenol have been determined

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2

Dekate, Shital M., Kishor M. Hatzade, and Ajay M. Ghatole. "A Facile Synthesis of Thiazole Derivatives bearing Imidazole Moiety, Schiff Bases and their O-Glucosides." Asian Journal of Chemistry 35, no. 1 (2022): 29–38. http://dx.doi.org/10.14233/ajchem.2023.24049.

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A unique approach for the synthesis of new thiazole O-glycosides is presented in this work. 2-Amino-4-hydroxy-phenyl-1,3-thiazole-5-carboxaldehyde (3a) was reacted with phenyl glyoxal and benzil to form 4-(4-hydroxy-phenyl)-5-(4-phenyl-1H-imidazol-2-yl)-thiazol-2-amine (4a) and 4-(4-hydroxy-phenyl)-5-(4,5-diphenyl-1H-imidazol-2-yl)-thiazol-2-amine (4b), respectively. A series of substituted Schiff bases of 4a and 4b were synthesized reacting with various aryl aldehyde to form 2-(imino substituted benzal)-4-(4-hydroxy-phenyl)-5-(4-phenyl-1H-imidazol-2-yl)-thiazoles (5a-e) and 2-(imino substitut

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3

Aleqsanyan, I. L., and L. P. Hambardzumyan. "Synthesis of Schiff Bases and Isoindolyl- and Thiazolyl-Substituted Quinolines from 6-Amino-2-methylquinolin-4-ol." Russian Journal of Organic Chemistry 58, no. 10 (2022): 1434–37. http://dx.doi.org/10.1134/s1070428022100086.

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4

Veerabhadraiah, Udarapu, Vedeela Rajeswar Rao, and Tadepalcy Venkata Padmanabha Rao. "Reaction of mercaptoacetic acid and chloroacetyl chloride with benzalamino thiazolyl coumarins." Collection of Czechoslovak Chemical Communications 55, no. 2 (1990): 535–39. http://dx.doi.org/10.1135/cccc19900535.

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2-Aryl-3-[4-(2-oxo-2H-1-benzopyran-3-yl)-2-thiazolyl]-4-thiazolidinones (III), have been synthesized by the reaction of Schiff's bases (II) derived from 3-(2-amino-4-thiazolyl)-2H-1-benzopyran-2-ones (I) with mercaptoacetic acid. The Schiff's bases on reaction with chloroacetyl chloride in the presence of triethylamine in dioxane gave chloroacetamido derivative (IV) instead of expected compound V.

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5

P. Kavitha and N. Vijayakumari. "SYNTHESIS AND CHARACTERIZATION OF BENZOTHIAZOLE SCHIFF BASES BASED METAL COMPLEXES AND THEIR BIOLOGICAL APPLICATIONS." RASAYAN Journal of Chemistry 18, no. 02 (2025): 1170–76. https://doi.org/10.31788/rjc.2025.1829261.

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A new benzothiazole Schiff base ligand named (E)-N-(6-((2-hydroxy-5-methylbenzylidene)amino)benzo[d]thiazol-2- yl)cyclohexane-carboxamide (BSB) was prepared through the condensation reaction of N-(6-aminobenzo[d]thiazol2-yl)cyclohexane-carboxamide with substituted aldehyde. Mass, FT-IR, NMR, and spectral techniques confirmed the synthesized ligand. The resulting compound was tested with the coordination behavior of a series of various d-block metal ions named Cu2+, Zn2+, Co2+, and Ni2+, with the prepared (BSB) reported. The bonding behavior and the complexes' performance have been assumed as p

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6

Sonparote, P. M., and D. M. Chavhan. "Convenient Method for Synthesis of New Derivatives of (1-(4-(2,4-dichlorophenyl)-2-((4-nitrobenzylidene) amino)thiazol-5-yl)ethan-1-one." International Research Journal of Pure and Applied Chemistry 24, no. 5 (2023): 139–44. http://dx.doi.org/10.9734/irjpac/2023/v24i5833.

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The new derivatives of thiazole based Schiff base of (1-(5-(2,3,4-trisubstitutedphenyl)-2-((4-nitrobenzylidene)amino)thiazol-4-yl)ethan-1-one (6) were synthesized by the treatment of 1-(2-amino-5-(2,3,4-trisubstitutedphenyl)thiazol-4-yl)ethan-1-one (4) and corresponding substituted benzaldehyde (5) in low cost easily available non flammable stable and ecofriendly solvent Polyethylene glycol-400 solvent medium. The reactions were performed in the good yield and less time. The structures of all synthesized compounds were established on the basis of elemental analysis, IR, NMR and Mass spectral d

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7

Ahmed, Amena Alyas, Natiq Ghanim Ahmed, and Ahmad Khuder Ahmad. "Synthesis of New Substituted Tetrazole and 4-Thiazolidinone from Schiff's Bases." Pakistan Journal of Scientific & Industrial Research Series A: Physical Sciences 63, no. 1 (2020): 1–11. http://dx.doi.org/10.52763/pjsir.phys.sci.63.1.2020.1.11.

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 The present work involved the synthesis of compound (1) (1-amino-4-methyl-6-phenyl pyrimidine- 2-(1H)-thione). This compound reacts with different aromatic aldehyde using glacial acetic acid as catalytic on absolute ethanol to give a new series of Schiff's bases (2-7). New thiazolidine-4-one were prepared from reactions of Schiff's bases (2,3,4,7) with thioglycolic acid in absolute ethanol giving compounds (8-11). Finally the preparation of new tetrazole derivatives (12-15) by reaction of Schiff's bases (2,3,4,7) with sodium azide in THF. The structure of the synthesized compounds are c

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8

Sahoo, C. R., R. Patro, J. Sahoo, R. N. Padhy, and S. K. Paidesetty. "DESIGN, MOLECULAR DOCKING OF SYNTHESIZED SCHIFF-BASED THIAZOLE/ PYRIDINE DERIVATIVES AS POTENT ANTIBACTERIAL INHIBITOR." INDIAN DRUGS 56, no. 11 (2019): 20–25. http://dx.doi.org/10.53879/id.56.11.12007.

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A series of N-(substituted benzylidene) thiazol-2-amines (3a-3d) and N-(substituted benzylidene) pyridyl-2-amines (3A-3D) were synthesized and individual structures were confirmed by several spectral techniques. Antibacterial activity of synthesized Schiff-base derivatives were performed by agar-diffusion method. These compounds were screened by in vitro antibacterial activity against uropathogenic bacteria, Escerichia coli and Klebsiella pneumoniae. The compounds 3a, 3B and 3d had the best inhibititory activity against K. pneumonia, whereas, the other derivatives had moderate activity. The co

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9

Singh, Gurvinder P., Saravanan Kaliyaperymal, and Gyanendra K. Sharma. "Microwave-assisted Solvent-free Synthesis of Some New 4-[2-(Substituted phenyl)-4, 5-diphenyl-1H-imidazole-1-yl]-1H-indoles of Biological Interest." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 02 (2024): 253. http://dx.doi.org/10.59467/ijhc.2024.34.253.

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Solvent-free, microwave-assisted synthesis of several new indolyl imidazoles of biological importance is reported. First, indoleamine was condensed with substituted aryl aldehydes to give corresponding Schiff's bases. Then, Schiff's bases were reacted with ammonium acetate and benzil using silica gel as the solid support to yield the corresponding substituted indolyl imidazole derivatives. A comparison between the conventional approach and the microwave-assisted method is also reported in this research. All the synthesized substituted indolyl imidazole derivatives showed good antibacterial act

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10

Al-Smaism, Rafah F., Ayad M. R. Raauf, Basma M. Abd Razik, and Hala A. M. Rasheed. "Synthesis, Characterization and Antimicrobial Activityof 3-substituted Benzo[4,5]thiazolo[2,3-c][1,2,4]triazole." Al Mustansiriyah Journal of Pharmaceutical Sciences 13, no. 2 (2013): 9–15. http://dx.doi.org/10.32947/ajps.v13i2.195.

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New series of tricyclic benzo[d]thiazole derivatives (2-12) incorporated into fused to different five membered nitrogen and sulphur containing heterocyclic were prepared from 2- hydrazinobenzo[d]thiazole (1) when treated with triethylformate, acetic anhydride, ethyl chloro acetate, carbon disulphide in alkali, and urea respectively.Compound(1) converted to Schiff’s bases by the condensation different aromatic aldehydes, the synthesized Schiff’s bases were cyclized by bromine in acetic acid to form triazole ring in the new derivatives (7-11) , which might result in biologically active agents.Si

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11

Hiraki, Katsuma, Shingo Ibaraki, Masayoshi Onishi, Yuka Ono, Junko K. Kawashima, and Masako Ando. "Bicyclic cyclopalladated complexes derived from N-benzyl-substituted Schiff's bases." Journal of Organometallic Chemistry 547, no. 2 (1997): 199–207. http://dx.doi.org/10.1016/s0022-328x(97)00377-x.

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12

Ozokan, Kadri G., Mustafa K. Gumus, and Seniz Kaban. "Synthesis of hetaryl-substituted benzoxazolesviaoxidative cyclization of phenolic schiff's bases." Journal of Heterocyclic Chemistry 45, no. 6 (2008): 1831–34. http://dx.doi.org/10.1002/jhet.5570450643.

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13

A., O. Deshmukh, B. Raghuwanshi P., and A. Kalambe N. "Acoustic parameters by ultrasonic interferometric measurements of substituted Schiff's bases." Journal of Indian Chemical Society Vol. 87, Oct 2010 (2010): 1211–20. https://doi.org/10.5281/zenodo.5804911.

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Govt. Vidarbha Institute of Science & Humanities, Amravati, Maharashtra, India <em>E-mail :</em> deshmukhashwini 16@yahoo. in Brijlal Biyani Mahavidyalaya, Amravati-444 604, Maharashtra, India P, R. Patil College of Engineering & Technology, Amravati, Maharashtra, India <em>Manuscript received 26 October 2009, revised 12 April 2010, accepted 13 April 2010</em> In last four decades ultrasonic velocity and density measurement studies created its own importance in medicinal, pharmaceutical, anatomical, biochemical and chemical sciences<sup>1-4</sup>. As solute-solvent, solute-solute, solv

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14

S, Zine Babasaheb, Najan Sopan A, Dhonde Shrikant P, and Mazahar Farooqui. "Synthesis, Characterization and Biological Evaluation of Schiff's bases containing Indazole Moiety." Der Pharma Chemica 15, no. 3 (2023): 4. https://doi.org/10.5281/zenodo.13319875.

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Indazole containing derivatives represent one of the most important heterocycles in pharmaceuticals. Substituted indazole derivatives bear a variety of functional groups and display versatile biological activities. A series of new Indazolyl derivatives have been prepared from commercially available N-substituted-3-indazole carboxylic acid and methanol with sulphuric acid. Synthesis of these compounds proceeds through the formation of 1-ethyl-1H-indazole -3-carboxylate, by acidic esterification, then conveted in to 1-ethyl-1H-indazole -3-hydrazide using hyrdazine hydrate in ethanol at reflux te

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15

Babasaheb, S. Zine, A. Najan Sopan, and Farooqui Mazahar. "Synthesis, Characterization and Biological Evaluation of Schiff's bases containing Indazole Moiety." DER PHARMA CHEMICA 15, no. 3 (2023): 4. https://doi.org/10.4172/0975-413X.15.3.34-37.

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Indazole containing derivatives represent one of the most important heterocycles in pharmaceuticals. Substituted indazole derivatives bear a variety of functional groups and display versatile biological activities. A series of new Indazolyl derivatives have been prepared from commercially available N-substituted-3-indazole carboxylic acid and methanol with sulphuric acid. Synthesis of these compounds proceeds through the formation of 1-ethyl-1H-indazole -3-carboxylate, by acidic esterification, then conveted in to 1-ethyl-1H-indazole -3-hydrazide using hyrdazine hydrate in ethanol at reflux te

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16

S, Zine Babasaheb, Sopan A. Najan, Shrikant P. Dhonde, and Mazahar Farooqui. "Synthesis, Characterization and Biological Evaluation of Schiff's bases containing Indazole Moiety." Der Pharma Chemica 15, no. 3 (2023): 4. https://doi.org/10.5281/zenodo.10952012.

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Indazole containing derivatives represent one of the most important heterocycles in pharmaceuticals. Substituted indazole derivatives bear a variety of functional groups and display versatile biological activities. A series of new Indazolyl derivatives have been prepared from commercially available N-substituted-3-indazole carboxylic acid and methanol with sulphuric acid. Synthesis of these compounds proceeds through the formation of 1-ethyl-1H-indazole -3-carboxylate, by acidic esterification, then conveted in to 1-ethyl-1H-indazole -3-hydrazide using hyrdazine hydrate in ethanol at reflux te

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17

P., G. More, N. Muthal B., and A. S. Lawand (Mrs.). "Complex formation of some transition metals with thiazole Schiff bases." Journal of Indian Chemical Society Vol. 83, Jan 2006 (2006): 36–38. https://doi.org/10.5281/zenodo.5815137.

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Department of Chemistry, Shivaji University P.G. Centre, Kegaon, Solapur-413 255, Maharashtra, India Fax : 91-217-2744770 shri Sant Gadge Maharaj Mahavidyalaya, Loha, Dist. Nanded, Maharashtra, India Manuscript received 6 April 2005. revised 25 August 2005. accepted 9 September 2005 Proton-ligand stability constants of five Schiff bases, derived from 4-(p-bromophenyl)-2-aminothiazole and R substituted salicylaldehyde (R = H, 5-CH<sub>3</sub>, 4-CH<sub>3 </sub>and 5-Br) or 2-hydroxy-1-naphthaldehyde, and formation constants of their transition metal (Co<sup>II</sup>, Ni<sup>II</sup>, Cu<sup>II<

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18

Parcha, Versha, Ankit Kumar, Babita Mahajan, and Jaswinder Kaur. "Synthesis, characterization and biological evaluation of Schiff’s bases derivatives as potent antibacterial agents." Pharmaceutical and Biological Evaluations 4, no. 5 (2017): 216. http://dx.doi.org/10.26510/2394-0859.pbe.2017.34.

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Objective: To design, synthesize and screen biologically newer Substituted Schiff bases by condensing substituted acid hydrazides with various benzaldehydes and explore their antimicrobial potential.Methods: Present study synthesis of various derivatives of Schiffs bases was carried out by: firstly converting substituted acids to acid hydrazides and then to Schiff's bases after condensation with substituted benzaldehyde. Synthesized compounds were characterised on the basis of spectral studies (like UV, IR, and NMR). All the synthesized derivatives were screened further for their antibacterial

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19

1Devendra, K. Singh and 2Vipin K. Singh. "Study of Schiff's bases and its metal complexes for different Applications." Journal of Research & Development' 14, no. 7 (2022): 173–79. https://doi.org/10.5281/zenodo.6988274.

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<strong>Abstract:</strong> The focus on the current study is to investigate that the broad applications of the metal complexes with Schiff’s bases. Schiff’s bases are an important part of medical science. In many drugs, develops activities like antibacterial, antifungal and anticancer. The potency of these pharmaceutically useful drugs is a treatment for microbial infections and other activities that encourages the development of some more potent and momentous complex compounds. Schiff’s bases and their metal complexes are remarkably impressive compounds. On larger-scale bioc

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20

Valarmathy, Govindaraj, Ramanathan Subbalakshmi, Rajendran Nithya, Ragu Nandhini, Balachandaran Sabarika, and Elanchleiyan Aarthy. "Synthesis, Spectral Characterisation and Cytotoxic Evaluation of Substituted Sulfonamide Schiff Bases." Indian Journal of Science and Technology 14, no. 34 (2021): 2731–41. https://doi.org/10.17485/IJST/v14i34.888.

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Abstract <strong>Objectives:</strong> To synthesize Schiff bases i.e 4-((2-hydroxybenzylidene)-amino–N-(5-methyl-1,2-oxozol-3- yl)benzene sulphonamide (L1), 4-((2-hydroxy benzylidene)-amino-N-(thiazol-yl)benzene sulphonamide (L2), 4-((2-hydroxybenzylidene)amino-N-(pyridin-2-yl)benzene sulphonamide by theaction of 2-hydroxybenzaldehyde with sulfathiazole/ sulfamethoxazole/ sulfapyridine in ethanolic media. <strong>Methods:</strong> The Schiff bases obtained were characterized by analytical data, IR, UV, 1H- NMR, 13C-NMR, Mass spectrum and monitored for cytotoxic activity ag

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21

Zuhair Husain, Amra, Yassir S. Al-Jawaheri, and Amaal Y. Al-Assafe. "Synthesis of substituted heterocyclic with their cobalt(Ⅱ) complexes from 2-amino- thiazoles and evaluation of their biological activity." Bulletin of the Chemical Society of Ethiopia 38, no. 4 (2024): 909–22. http://dx.doi.org/10.4314/bcse.v38i4.8.

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In this research, acetophenone and thiourea reacted in the presence of iodine to produce 2-amino-4-phenylthiazoles (1, 2). These compounds were then used in three different reactions to create substituted Schiff-bases (3-5) by further reactions with substituted benzaldehyde. To produce thiazole, they were first reacted with sodium azide (6). After adding maleic anhydride, they interacted with thioglycolic acid to yield oxazepine (7), and lastly, thiazolidine (8). The synthesised compounds (1-8) were confirmed to have their structures clarified by CHNS and spectroscopic methods such as infrared

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22

Prakash, Ram, R. B. Singh, R. K. Vishnoi та K. Srivastava. "Synthesis, Characterization and biological activity of some novel heterocyclic β-lactam/thiazol compounds derived from 4-phenyl-4,5-dihydrothiazol-2-yl-imino". Research Journal of Chemistry and Environment 27`, № 10 (2023): 115–21. http://dx.doi.org/10.25303/2710rjce1150121.

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An efficient and convenient synthesis of β-lactam/ thiazol derivatives has been achieved by the reaction of acetophenone, substituted aromatic aldehyde and thiourea yield substituted schiff’s bases which further undergo the cyclization in the presence of chloroacetyl chloride, triethyl amine/ZnCl2, thioglycoolic acid. All the synthesized novel derivatives have been established by % of C, N, S elements, FT-IR, 1H NMR and Mass spectral studies. Further in-vitro antimicrobial activity of novel derivatives was carried out against some Gram-positive and Gram-negative bacteria by serial dilution met

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23

Neeraj, Kumar, Bhatt Dhruti, Shekhar Sharma Chandra, Pratap Singh Hamendra, Pandiya Harshda, and Yashwant. "Synthesis and Biological Evaluation of Chalconyl Incorporated Schiff's Bases of Sulphonamides." International Journal of Current Pharmaceutical Review and Research 9, no. 3 (2017): 249–52. https://doi.org/10.5281/zenodo.12674529.

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A series of of Chalconyl Incorporated Schiff’s Bases of Sulphonamides was synthesized by reacting substituted chalconederivatives with Sulphacetamide sodium in methanol. All the title compounds synthesized (2a-2d) were tested forantibacterial and antifungal activity using E. coli, P. aeruginosa, S. aureus, S. pyogenus and C. albicans, A. niger and A.clavatus respectively as microbial strains and Sulphacetamide sodium as standard. The compound 2d showed significantantibacterial activity and 2a showed moderate antifungal activity as compared with Sulphacetamide Sodium.

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24

Neeraj, Kumar, Bhatt Dhruti, Shekhar Sharma Chandra, Pratap Singh Hamendra, Pandiya Harshda, and Yashwant. "Synthesis and Biological Evaluation of Chalconyl Incorporated Schiff's Bases of Sulphonamides." International Journal of Current Pharmaceutical Review and Research 8, no. 3 (2017): 249–52. https://doi.org/10.5281/zenodo.12677543.

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A series of of Chalconyl Incorporated Schiff’s Bases of Sulphonamides was synthesized by reacting substituted chalconederivatives with Sulphacetamide sodium in methanol. All the title compounds synthesized (2a-2d) were tested forantibacterial and antifungal activity using E. coli, P. aeruginosa, S. aureus, S. pyogenus and C. albicans, A. niger and A.clavatus respectively as microbial strains and Sulphacetamide sodium as standard. The compound 2d showed significantantibacterial activity and 2a showed moderate antifungal activity as compared with Sulphacetamide Sodium.

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25

H. Abed Elwahab Al-Somaidai, Gazwan. "Synthesis and study the biological activity of some new derivatives of 1,2,4-triazole compounds." Tikrit Journal of Pharmaceutical Sciences 1, no. 1 (2023): 64–70. http://dx.doi.org/10.25130/tjphs.2005.1.8.64.70.

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Some derivatives of triazoles have been synthesized . These derivatives (Schiff's bases) were resulted from the reaction of (3-( 4-methoxy phenyl)-4-amino-5 mercapto-1,2,4-triazole and the corresponding substituted benzaldehydes in presence of glacial acetic acid . The chemical structures of the products were characterized by IR and UV spectra, elemental analysis C.H.N and the biological activity were studied against different kinds of bacteria.

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26

Sai Priya, D., S. G. Kini, V. G. Bhatt, E. Rathi, A. Muralidharan, and A. Koteshwara. "NOVEL SCHIFF'S BASES OF SUBSTITUTED 2-AMINO BENZOTHIAZOLES: DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY." INDIAN DRUGS 55, no. 04 (2018): 18–26. http://dx.doi.org/10.53879/id.55.04.11219.

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Novel Schiff’s bases bearing substituted 2-amino benzothiazole were synthesized by single step process through simple condensation of 2-amino benzothiazole and substituted benzaldehydes and further characterized by FTIR, 1HNMR, and Mass spectrometry data. Antimicrobial activity of compounds was performed by agar diffusion method against a panel of bacterial strains such as S. aureus, B. subtilis (Gram-positive bacteria), E. coli, P. aeruginosa (Gram-negative bacteria) and fungal strains such as C. albicans and A. niger. Compound S13 and S17 had shown potent antifungal activity against C. albic

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27

Verma, Abhay Kumar, Alex Martin, and Arun Kumar Singh. "Synthesis, Characterization and evaluation of Anti-inflammatory and Analgesic activity of Benzothiazole derivatives." Indian Journal of Pharmaceutical and Biological Research 2, no. 03 (2014): 84–89. http://dx.doi.org/10.30750/ijpbr.2.3.14.

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A parent benzothiazole nucleus was synthesized by para amino acetanilide, then it is subjected to treatment with various substituted aromatic aldehydes to get the corresponding Schiff’s bases followed by treatment with pthalic anhydride to form 2-(6- acetamidobenzo[d]thiazol-2-ylcarbamoyl)benzoic acid. The structures of synthesized compounds were confirmed by various spectroscopic methods such as IR, 1H NMR and mass spectroscopy. The products were evaluated for their anti-inflammatory and analgesic activities. Some of the compounds exhibited potent activities when compared with the standards.

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28

Malak, Sajid Ajit, Jamatsing Dabarsing Rajput, and Mustakim Sharif. "Design, synthesis, spectral analysis, and biological evaluation of Schiff bases with a 1,3,4-thiadiazole moiety as an effective inhibitor against bacterial and fungal strains." European Journal of Chemistry 14, no. 4 (2023): 466–72. http://dx.doi.org/10.5155/eurjchem.14.4.466-472.2468.

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Many distinct natural and pharmaceutical items include the well-known heterocyclic nucleus 1,3,4-thiadiazole. Ten Schiff bases of 1,3,4-thiadiazole derivatives have been synthesized using equimolar amounts of 5-styryl-1,3,4-thiadiazol-2-amine and substituted acetophenones in the catalytic amount of ethanol. The synthesized derivatives of Schiff's bases were characterized by FT-IR, 1H NMR, 13C NMR, and mass spectroscopy. The 1,3,4-thiadiazole Schiff’s bases (RM-1 to RM-10) were tested for their in vitro antimicrobial activity against Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis,

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29

Farhan, Mohammed Alwan, Wijdan Amer Ibrahim, and Wassan Baqir Ali. "Synthesis, Evaluation of anticancer and antimicrobial activities of some Schiff bases derivatives." Al-Kitab Journal for Pure Sciences 7, no. 2 (2023): 115–29. http://dx.doi.org/10.32441/kjps.07.02.p10.

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In this research, compound [1,2-Bis-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-ethane-1,2-diol] was used as starting material for synthesis different Schiff's Bases compounds. The fusion of tartaric acid with thiocarbohydrazide produce the compound (C1), the Schiff's bases (C2-C4) were created through the condensation of substances (C1) with different substituted benzaldehydes in presence of glacial acetic acid as catalyst. Thin layer chromatography (TLC) was used to confirm the compounds' purity, and spectroscopic methods were used to infer the compounds' structures (FTIR) and magnetic nucle

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30

Chohan, Zahid H. "Ni (II), Cu (II) and Zn (II) Metal Chelates With Some Thiazole Derived Schiff-Bases: Their Synthesis, Characterization and Bactericidal Properties." Metal-Based Drugs 6, no. 2 (1999): 75–80. http://dx.doi.org/10.1155/mbd.1999.75.

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A number of thiazole derived tridentate Schiff-bases (LH) and its metal chelates of the type [M(L)2X] where M=Ni(II), Cu(II) and Zn(II), L=substituted salicylaldehyde (5-H, 5-CH3, 5-OCH3, 5-NO2 and 5-Cl) and X=CI have been synthesized and characterized with the help of elemental analyses, conductivity measurements, magnetic moments, UV-Vis, IR and NMR spectral data. An octahedral structure for Ni(II) and Zn(II) and a distorted octahedral structure for Cu(II) chelates have been proposed. All the Schiff-bases and their metal chelates have been screened for their biological activity against Esche

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31

Bansode, Vishakha, and Meenakshi N. Deodhar. "Synthesis and Evaluation of Some Coumarin Based Schiff's Bases as Potential Antimicrobial Agents'." E-Journal of Chemistry 9, no. 4 (2012): 2079–88. http://dx.doi.org/10.1155/2012/791091.

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A series of the title compounds 3-(4-(4, 5-dihydro-5-(substituted phenyl)-1H-3-pyrazolyl) phenylimino) methyl)-4-chloro-2H-chromen-2-one 5(a-g) have been synthesized. These compounds were characterized on the basis of their spectral (IR,1H NMR) data and evaluated for antimicrobial activityin vitroagainst gram positive bacteria, gram negative bacteria and fungi. The compound (5b) was found to be the most active with MIC of 20 µg/ml against all the tested organisms.

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Sabry, Nermien M., Eman M. Flefel, Mohamed A. Al-Omar, and Abd El-Galil E. Amr. "Synthesis and Antimicrobial Activities of Some New Synthesized Imide and Schiff's Base Derivatives." Journal of Chemistry 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/106734.

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A series of 2,6-bis(substituted thiazolopyrimi-dinyl) pyridine(2a,b)and corresponding Schiff's bases(3a–j)were synthesized from 2,6-bis-(3-amino-2-methyl-4-oxo-9-substituted-3,4-dihydropyrido-[30,20 : 4,5]-thieno[3,2-d]pyrimidin-7-yl)pyridines(1a,b)as starting materials. The compounds1a,bwere reacted with 2,3,4,5-tetrachlorophthalic anhydride in glacial acetic acid to give the corresponding bis-imides(2a,b). But they are treated with aromatic aldehydes in refluxing ethanol to afford the Schiff’s base derivatives(3a–j). The antimicrobial screening showed that many of these newly synthesized com

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Gulyakevich, O. V., and A. L. Mikhal'chuk. "Cyclocondensation of benzylideneanilines with 2-(thiazolyl-4)cyclohexane-1,3-dione hydrochlorides. A novel reaction in the series of Schiff's bases." Russian Chemical Bulletin 44, no. 10 (1995): 1977–78. http://dx.doi.org/10.1007/bf00707246.

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Valarmathy, G., R. Subbalakshmi, B. Sabarika, and C. Nisha. "Schiff bases derived from 4-amino-N-substituted benzenesulfonamide: synthesis, spectral characterisation and MIC evaluation." Bulletin of the Chemical Society of Ethiopia 35, no. 2 (2021): 435–48. http://dx.doi.org/10.4314/bcse.v35i2.16.

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ABSTRACT. The present study is aimed to synthesise Schiff bases from sulfathiazole/ sulfamethoxazole/ sulfadimidine with 2-hydroxybenzaldehyde. The synthesized Schiff bases were characterized by analytical data, IR, 1H-NMR, 13C-NMR, UV-Vis spectra, mass spectra and screened for antibacterial activity against gram positive bacteria Staphylococcus aureus and gram negative bacteria Salmonella typhiand antifungal activity against Candida albicans and Mucor by disc diffusion method. Zone of inhibition indicated that the Schiff base possessed highly potent antimicrobial activity when compared to sul

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Maitra, A. M., and E. Patsalides. "Thermoanalytical and gas chromatographic properties of the copper(II) complexes of alkyl-substituted Schiff's bases." Chromatographia 31, no. 1-2 (1991): 11–16. http://dx.doi.org/10.1007/bf02290489.

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Sharma, K. S., and K. Bhushan. "Organic photochemistry V: photochemistry of substituted Schiff's bases—search for luminescent dyes for solar collectors." Journal of Photochemistry and Photobiology A: Chemistry 40, no. 2-3 (1987): 371–80. http://dx.doi.org/10.1016/1010-6030(87)85014-1.

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R., Rajalakshmi, and Elakiya T. "Effect of substituents on infrared, H1 and C13NMR spectra of Schiff's bases derived from Furfuryl amine." International Journal of Trend in Scientific Research and Development 2, no. 2 (2018): 550–54. https://doi.org/10.31142/ijtsrd8380.

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Several substituted Schiff,s bases have been derived from furfuryl amine and their IR, 1H and 13C NMR spectra are recorded. The IR C=N cm 1 , NMR d ppm of CH=N spectral data have been correlated with Hammett substituent constants and Swain Lupton's parameters using single and multi linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. R. Rajalakshmi | T. Elakiya "Effect of substituents on infrared, H1 and C13NMR spectra of Schiff's bases derived from Furfuryl amine" Published in Internatio

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38

Guittard, F., P. Sixou, and A. Cambon. "Comparison of the Mesomorphic Properties Between Substituted Schiff's Bases Incorporating a Linear Hydrocarbon or Fluorinated Tail." Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals 308, no. 1 (1997): 83–92. http://dx.doi.org/10.1080/10587259708045096.

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Journal, Baghdad Science. "Synthesis and Evaluation Antibacterial Activity of Some New Substituted 5-Bromoisatin Containing Five, Six Heterocyclic Ring." Baghdad Science Journal 13, no. 2 (2016): 345–59. http://dx.doi.org/10.21123/bsj.13.2.345-359.

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This research includes the synthesis of some new different heterocyclic derivatives of 5-Bromoisatin. New sulfonylamide, diazine, oxazole, thiazole and 1,2,3-triazole derivatives of 5-Bromoisatin have been synthesized. The synthesis process started by the reaction of 5-Bromoisatin with different reagents to obtain schiff bases of 5-Bromoisatin intermediate compounds(1, 8, 19) by using glacial acetic acid as a catalyst in three routes. The first route, 5-Bromoisatin reacted with p-aminosulfonylchloride to product compound(1), then converted to sulfonyl amide derivatives(2-7) by the reaction of

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Devi, Kalpana, and Monica Kachroo. "Synthesis and Docking Studies of Oxazine Derivatives as Anti-inflammatory and Antioxidant Agents." DER PHARMA CHEMICA 13, no. 3 (2021): 9. https://doi.org/10.5281/zenodo.11070994.

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A new series of N-(4-{4-(substituted phenyl)-2-[(4-fluro-benzylidene)-amino]-6H-[1,3] oxazine-6-yl}-phenyl)-isonicotiamide were synthesized by reaction of p-amino acetophenone with isonicotinyl chloride to obtain the secondary amides. ClaisenSchmidth condensation reaction with substituted aldehydes led to the formation of corresponding chalcones. These chalcones were cyclized with urea to form oxazine which further reacted with p-fluorobenzaldehyde to form the corresponding Schiff’s bases. All the synthesized compounds were characterized by IR and 1HNMR spectral data, mass spectra and el

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Devi, Kalpana, and Monica Kachroo. "Synthesis and Docking Studies of Oxazine Derivatives as Anti-inflammatory and Antioxidant Agents." Der Pharma Chemica 13, no. 3 (2021): 9. https://doi.org/10.5281/zenodo.14722735.

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A new series of N-(4-{4-(substituted phenyl)-2-[(4-fluro-benzylidene)-amino]-6H-[1,3] oxazine-6-yl}-phenyl)-isonicotiamide were synthesized by reaction of p-amino acetophenone with isonicotinyl chloride to obtain the secondary amides. ClaisenSchmidth condensation reaction with substituted aldehydes led to the formation of corresponding chalcones. These chalcones were cyclized with urea to form oxazine which further reacted with p-fluorobenzaldehyde to form the corresponding Schiff’s bases. All the synthesized compounds were characterized by IR and 1HNMR spectral data, mass spectra and el

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42

D.T., Biradar, and M. B. Swami Dr. "Synthesis of Schiff's Bases from 2-Amino-4H-1, 3-Oxazine / Thiazine and Substituted Aldehydes and their Transition Metal Complexes." International Journal of Current Science Research and Review 04, no. 07 (2021): 677–83. https://doi.org/10.47191/ijcsrr/V4-i7-09.

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Abstract : Objective: Many methods can be found in literature for the synthesis a Oxazines and Thiazines. Few are reported for one-pot multi component cyclo-condensation of an alkayane urea / Thiourea and Aldehyde to 2- amino-4H-1, 3-Oxazines or Thiazines. Different catalysts are reported like Trifluoro-acetic acid, glacial acetic acid under reflux condition Mandal and Co-workers have utilized perchloric acid (HClO4) supported on silica gel as catalyst under solvent free condition ytterbium trifluorate [Yb(OTF)3] plays role of Lewis acid. It is also used in several Diel’s-Alder cyclo-add

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Biswa, Mohan Sahoo, Nagamounika K., and Krishna Banik Bimal. "Microwave-assisted synthesis of Schiff's bases of 1,2,4-triazole derivatives and their anthelmintic activity." Journal of Indian Chemical Society Vol. 95, Nov 2018 (2018): 1289–94. https://doi.org/10.5281/zenodo.5652476.

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Department of Pharmacy, Vikas Group of Institutions, Nunna, Krishna District, Vijayawada-521 229, Andhra Pradesh, India E-mail: drbiswamohansahoo@gmail.com Community Health System of South Texas, Edinburg, Texas 78539, USA E-mail: bimalbanik10@gmail.com <em>Manuscript received on line 26 September 2018, accepted 01 November 2018</em> Schiff’s bases of 1,2,4-triazole-3-thiol are synthesized by multistep reactions. Schiff bases are the condensation products of primary amines with carbonyl compounds. These compounds possess imine or azomethine (-C=N-) functional group in their structure and

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Prasad, V., and B. K. Sadashiva. "Liquid Crystalline Properties of o-Hydroxy Substituted Schiff's Bases and their Copper(II) and Palladium(II) Complexes." Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals 225, no. 1 (1993): 303–12. http://dx.doi.org/10.1080/10587259308036236.

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Ali, Esraa M., Ahmed W. Naser, and Muthanna S. Farhan. "SYNTHESIS OF SOME NEW HETEROCYCLIC COMPOUNDS DERIVED FROM N-(Ñ-PHENYL GLYCYL) SACCHARIN AND STUDY THEIR BIOLOGICAL ACTIVITY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 10 (2018): 555. http://dx.doi.org/10.22159/ajpcr.2018.v11i10.29048.

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Objective: In the present work, a variety of new heterocyclic compounds namely aza-β- lactam, cyclicimides, 1,3-thiazole, and 1,2,4-triazole.Methods: Procedure includes the synthesis of aza-β- lactam, cyclic imides, 1,3-thiazole, and 1,2,4-triazole. The synthesis was carried out in eleven steps using N-(Ñ-substituted phenylglycyl) saccharin derivatives (1a,b) as a starting material and converted to benzoic acid derivatives (2a,b) and then to ester derivatives (3a,b), which finally convers to benzohydrazide derivatives (4a,b). The cyclization of (4a,b) with carbon disulfide and hydrazine hydrat

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Lin, Shou-Yuan, Huai-Yu Sheng, and Yao-Zeng Huang. "A Convenient Palladium-Catalyzed Synthesis of Alkynyl Substituted Schiff's Bases by Coupling of Imidoyl Chlorides with 1-Alkynes." Synthesis 1991, no. 03 (1991): 235–36. http://dx.doi.org/10.1055/s-1991-26432.

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Tahtaci, Hakan, Mustafa Er, Tuncay Karakurt, and Abdurrahman Onaran. "Synthesis, Structural Characterization, and Biological Evaluation of Novel Substituted 1,3-Thiazole Derivatives Containing Schiff Bases." Journal of Heterocyclic Chemistry 54, no. 1 (2015): 183–93. http://dx.doi.org/10.1002/jhet.2565.

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Abood S Huda, Abdullah S. Asia, and Wrewish S Zainab. "Synthesis, characterization and antibacterial studies of Schiff bases of acyclovir." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 411–15. http://dx.doi.org/10.26452/ijrps.v11i1.1835.

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There is a crucial medical need for the progress of new antibacterial agents with new and more efficient mechanisms. Schiff bases are stated to have a wide range of pharmacological activities, including antimicrobial, antibacterial, antifungal, antioxidant, and anticancer activities, which are largely due to the distinguishing C=N group. Furthermore, heterocyclic compounds containing acyclic hydroxylated side chains, for example, acyclovir (ACV), are an essential class of antiviral acyclonucleosides. Therefore, this work was to synthesize and evaluate a new series of acyclovir analogues bearin

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Goomer, N. C., P. V. Kulkarni, A. Constantinescu, P. Antich, R. W. Parkey, and J. R. Corbett. "Synthesis and evaluation of technetium-99m monocationic mixed ligand complexes of phenyl substituted/condensed tetradentate schiff's bases and trimethylphosphine." International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 19, no. 6 (1992): 679–84. http://dx.doi.org/10.1016/0883-2897(92)90102-5.

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Donthukurthi, Saisuryanarayana, Devdatt J. Patel, Rakesh I. Patel, and Piyush J. Vyas. "Synthesis, Characterization and Antimicrobial Activity of Thiazolo-oxazine Fused Heterocyclic Derivatives, Based on Benzene Sulfonyl Hydrazide." Oriental Journal Of Chemistry 39, no. 3 (2023): 721–26. http://dx.doi.org/10.13005/ojc/390323.

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Schiff bases of Benzene sulfonyl hydrazide (SBSZ) (1a-e) were prepared by using various benzaldehyde derivatives. (1a-e) SBSZ were then condensed with mercapto acetic acid. The obtained resultant 2-thiazolidinone derivatives (2a-e) were then condensed with 5-nitro-2furfuralidine derivatives i.e. (Z)-N-(5-((5-nitrofuran-2-yl) methylene)-4-oxo-2-substitutedthiazolidin-3-yl) benzenesulfonamide (3a-e). These derivatives were further condensed with phenyl urea to yield fused heterocyclic derivatives i.e. N-(2-substituted-7-(5-nitrofuran-2-yl)-5-(phenylamino)-2H-thiazolo[5,4-e] [1,3]oxazin-3(3aH)-yl

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