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Relevant bibliographies by topics / Thieno[2,3-d]pyrimidine

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Academic literature on the topic 'Thieno[2,3-d]pyrimidine'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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Journal articles on the topic "Thieno[2,3-d]pyrimidine"

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Stasevych, Maryna, Svitlana Sabat, Rostyslav Musyanovych, and Volodymyr Novikov. "Synthesis of condensed S-, N- containing heterocyclic systems on the base of 2-amino-4,9-dioxo-4,9-dihydronaphto[2,3-b]thiophene-3-ethylcarboxilate." Chemistry & Chemical Technology 2, no. 3 (2008): 157–62. http://dx.doi.org/10.23939/chcht02.03.157.

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Synthesis of a new 2-aryl-4Н-naphtho[2’,3’,4,5]thieno[2,3-d][1,3]oxazine-4,5,10-triones, 2-arylnaphtho[2’,3’,4,5]thieno[2,3-d][1,3]pyrimidine-4,5,10(3Н)-triones, 3-phenyl naphtho[2’,3’,4,5]thieno[2,3-d][1,3]pyrimidine-2,4,5,10(1Н, 3Н)-tetraone and 2-thioxo-2,3-dyhydronaphth[2’,3’,4,5]thieno[2,3-d]pyrimidine-4,5,10(1Н)-trione was carried out. The mechanism of 2-aryl-4Н-naphtho[2’,3’,4,5]thieno[2,3-d][1,3]oxazine-4,5,10-triones formation was suggested.

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Kut, D., M. M. Kut, and R. T. Mariychuk. "SYNTHESIS OF N-ALKENYL(ALKYNYL)-5,6-DIMETHYL-2-(THIOPHEN-2-YL)THIENO[2,3-d]PYRIMIDIN-4-AMINES AND THEIR IN SILICO STUDY ON GROUP II CHITINASE (ChtII) INHIBITION." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 52, no. 2 (2024): 75–82. https://doi.org/10.24144/2414-0260.2024.2.75-82.

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Research in the chemistry of heterocyclic compounds, particularly condensed pyrimidine frameworks, aimed at developing drugs with diverse therapeutic properties. Among these compounds, special attention is given to thieno[2,3-d]pyrimidine derivatives due to their potential as drug candidates. This study presents the synthesis of a series of N-alkenyl(alkynyl)-5,6-dimethyl-2-(thiophen-2-yl)-thieno[2,3-d]pyrimidin-4-amines via the amination reaction of 5,6-dimethyl-2-(thiophen-2-yl)-4-chlorothieno[2,3-d]pyrimidine with unsaturated amines (allyl-, diallyl-, and propargylamine), enabling potential

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Shevchenko, Nadiya М., Oleksandr O. Severin, Maryna V. Kachaeva, Oleksandr Р. Kozachenko, Yevheniia S. Velihina, and Volodymyr S. Brovarets. "Synthesis of new pyrrolo[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives of piperazin-1-yl-1,3-oxazole-4-carbonitriles, prediction and evaluation of their ADMET properties." Ukrainica Bioorganica Acta 19, no. 2 (2024): 21–32. https://doi.org/10.15407/bioorganica2024.02.021.

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The discovery of nucleoside antibiotics gave impetus to the development of the chemistry of pyrrolo[2,3-d]pyrimidines and thieno[2,3-d]pyrimidines as biologically active compounds. This work describes a universal and efficient approach to the synthesis of new pyrrolo[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives of piperazin-1-yl-1,3-oxazole-4-carbonitriles. Their potential as biologically active compounds is considered and ADMET-score is predicted to assess their further application as pharmaceutical substances

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Ahmed, Essam K., Johannes Fröhlich, and Fritz Sauter. "Fusion Reactions of N-Heterocyclic Moieties to Thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidines." Collection of Czechoslovak Chemical Communications 61, no. 1 (1996): 147–54. http://dx.doi.org/10.1135/cccc19960147.

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Derivatives of the novel heterocyclic parent systems imidazolo[1,2-a]thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidine (B) and thiopyrano[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine (C) have been synthesized by fusing pyrimidine moieties to 2-amino-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid ethyl ester (1) and -3-carbonitrile (10), followed by cyclization reactions of the title intermediates A thus obtained.

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Singh, Shiv Dev, Arvind Kumar, Firoz Babar, Neetu Sachan, and Arun Kumar Sharma. "Synthesis of Novel 3(N,N-dialkylamino)alkyl/phenyl Substituted Thieno [2,3-d]pyrimidinones as H1-Anti-Histaminic and Antimicrobial Agents." Current Bioactive Compounds 15, no. 1 (2019): 63–70. http://dx.doi.org/10.2174/1573407214666180226130957.

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Background: Thienopyrimidines are the bioisoster of quinazoline and unlike quinazoline exist in three isomeric forms corresponding to the three possible types annulation of thiophene to the pyrimidine ring viz thieno[2,3-d] pyrimidine, thieno[3,2-d] pyrimidine and thieno[3,4-d]pyrimidine. Heterocyclic containing the thienopyrimidinone moiety exhibits various pronounced activities such as anti-hypertensive, analgesic and anti-inflammatory, antiviral, platelet aggregation inhibitory, antiprotozoal bronchodilatory, phosphodiesterase inhibitory, antihistaminic, antipsychotic and antimicrobial acti

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Hossain, M. I., and M. M. H. Bhuiyan. "Synthesis and Antimicrobial Activities of Some New Thieno and Furopyrimidine Derivatives." Journal of Scientific Research 1, no. 2 (2009): 317–25. http://dx.doi.org/10.3329/jsr.v1i2.2299.

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Fused pyrimidines, 8,9-dimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 5, 3,8,9-trimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 6, 4-benzylidinehydrazono-5,6 dimethylthieno[2,3-d]pyrimidine 7, 4-[4/-hydroxybenzylidine]hydrazono-5,6-dimethylthi-eno[2,3-d]pyrimidine 8, 4-[4/-tolylidin]hydrazono-5,6-dimethylthieno[2,3-d]pyrimidine 9, 4-[4/-nitrobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 10 and 4-[4/-chlorobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 11 are prepared in good yield by an initial treatment of 2-amino-4,5-dimethylthiophene-3-carbonitril

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Yin, Xuelian, Sung Min Kim, and Yang-Heon Song. "1,3-Bis(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)imidazolidine-4,5-dione." Molbank 2022, no. 3 (2022): M1403. http://dx.doi.org/10.3390/m1403.

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A thieno[2,3-d]pyrimidine derivative 3 bearing a 4,5-imidazolidinedione moiety, 1,3-bis(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)imidazolidine-4,5-dione, was efficiently synthesized in 66% yield by the reaction of N,N′-bis(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)methanediamine 2 with oxalyl chloride in the presence of pyridine in refluxing dichloroethane for 10 h. The structure of the new synthesized compounds was fully characterized by 1H, 13C NMR, IR spectroscopy, mass-spectrometry and elemental analysis.

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Kryvoruchko, A. R., D. Kut, M. M. Kut, and A. O. Krivovjaz. "INTERACTION OF 4-(ALLYLOXY)-5,6-DIMETHYL-2-(THIOPHEN-2-YL)THIENO[2,3-d]PYRIMIDINE WITH TELLURIUM-CONTAINING ELECTROPHILIC REAGENTS." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 52, no. 2 (2024): 47–52. https://doi.org/10.24144/2414-0260.2024.2.47-52.

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The chemistry of tellurium-containing electrophilic reagents remains less explored and studied compared to other chalcogen-containing electrophiles. This study investigates the interaction of tellurium tetrahalides and p-methoxyphenyltellurium trichloride with 4-(allyloxy)-5,6-dimethyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidine. It was found that reactions with in situ generated tellurium tetrahalides in glacial acetic acid lead to the formation of adducts with a 1:1 composition of 4-(allyloxy)-5,6-dimethyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidine-tellurium tetrahalide, confirmed by ¹H NMR spect

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Yin, Xuelian, and Yang-Heon Song. "5-Methyl-1-phenyl-3-(thieno[2,3-d]pyrimidin-4-yl)chromeno[4,3-d]pyrazolo[3,4-b]pyridin-6(3H)-one." Molbank 2022, no. 4 (2022): M1469. http://dx.doi.org/10.3390/m1469.

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A chromeno[4,3-d]pyrazolo[3,4-b]pyridinone derivative 3 bearing thieno[2,3-d]pyrimidine moiety, 5-methyl-1-phenyl-3-(thieno[2,3-d]pyrimidin-4-yl)chromeno[4,3-d]pyrazolo[3,4-b]pyridin-6(3H)-one, was efficiently prepared in 75% yield by the reaction of 3-phenyl-1-(thieno[2,3-d]pyrimidin-4-yl)-1H-pyrazol-5-amine 1 with 3-acetyl-2H-chromen-2-one 2 in the presence of FeCl3-SiO2 as a catalyst in refluxing ethanol for 6 h. The structure of the new synthesized compound was characterized by 1H-, 13C- NMR, IR spectroscopy, mass-spectrometry, and elemental analysis.

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10

Vlasov, Sergiy, Hanna Severina, Olena Vlasova, et al. "Synthesis, docking study and antimicrobial activity evaluation of pyridyl amides of thieno[2,3-d]pyrimidine-4-carboxylic acid." ScienceRise: Pharmaceutical Science, no. 5(45) (October 31, 2023): 53–62. http://dx.doi.org/10.15587/2519-4852.2023.286008.

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The aim. The combination in one molecule of pharmacophore fragments of thieno[2,3-d]pyrimidine-4-carboxylic acids with the fragments of 2- or 4-aminopyrimidine by peptide coupling promoted acylation in order to develop the new drug-like molecules with antimicrobial activity. Materials and methods. The molecular docking studies were performed with the AutoDock Vina та AutoDockTools 1.5.6 programs; TrmD Pseudomonas aeruginosa PDB ID – 5ZHN was used as the protein target. Synthetic methods of peptide coupling were used. 1H and 13C NMR spectra were recorded with a Varian-400 spectrometer at 400 MH

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Dissertations / Theses on the topic "Thieno[2,3-d]pyrimidine"

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Xu, Kuiying. "Pyrrolo[2,3-d]pyrimidine, Pyrazolo[3,4-d]pyrimidine and Triazolo[4,5-d]pyrimidine nucleosides and oligonucleotides: Synthesis, physical properties and base-pairing = Pyrrolo[2,3-d]pyrimidin, Pyrazolo[3,4-d]pyrimidin und Triazolo[4,5-d]pyrimidin nucleoside und oligonucleotide: Synthese, physikalische Eigenschaften und Basenpaarung /." Osnabrück, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254557.

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Le, Corre Laurent. "Synthèse et évaluation biologique d’inhibiteurs de FGFR3 de structure pyrazolooxadiazole, pyrido- et pyrazolopyrimidine." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P636.

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FGFR3 est un récepteur cellulaire impliqué dans de nombreux processus biologiques chez l’homme. La dérégulation de l’activité tyrosine kinase de FGFR3 est à l’origine d’anomalies de croissance osseuse et de certains cancers (myélome multiple, vessie). Le blocage de ce récepteur par des inhibiteurs compétitifs de l’ATP constitue une approche thérapeutique intéressante. La première partie de la thèse a concerné la préparation d’analogues du PD173074, inhibiteur nanomolaire de FGFR3, issu de l’industrie. Basée sur un squelette pyrido[2,3-d]pyrimidine, une chimiothèque de triazoles a été obtenue v

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Griffon, Du Bellay Amaury. "Synthèse de ligands du récepteu de l'Urotensine II et des récepteurs de la Mélatonine. Composés à noyau pyrido[2,3-d]pyrimidine ou imidazo[1,2-a]pyridine." Phd thesis, Université d'Orléans, 2008. http://tel.archives-ouvertes.fr/tel-00418219.

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L'Urotensine II est un peptide vasoactif que l'on retrouve chez toutes les espèces étudiées. Elle présente une partie N-terminale linéaire variable selon l'espèce et une partie C-terminale hexocyclique constante et responsable de l'activité. Parmi les ligands développés, le Palosuran, un inhibiteur sélectif du récepteur de l'Urotensine II, présente un intérêt dans le traitement de l'insuffisance rénale du patient diabétique voire dans certaines pathologies ischémiques. Dans la première partie de ce travail de thèse, une série de composés à noyau pyrido[2,3-d]pyrimidine a été développée, tout d

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Griffon, du Bellay Amaury. "Synthèse de ligands du récepteur de l'Urotensine II et des récepteurs de la Mélatonine : composés à noyau pyrido[2,3-d]pyrimidine ou imidazo[1,2-a]pyridine." Orléans, 2008. http://www.theses.fr/2008ORLE2059.

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L’Urotensine II est un peptide vasoactif que l’on retrouve chez toutes les espèces étudiées. Elle présente une partie N-terminale linéaire variable selon l’espèce et une partie C-terminale hexocyclique constante et responsable de l’activité. Parmi les ligands développés, le Palosuran, un inhibiteur sélectif du récepteur de l’Urotensine II, présente un intérêt dans le traitement de l’insuffisance rénale du patient diabétique voire dans certaines pathologies ischémiques. Dans la première partie de ce travail de thèse, une série de composés à noyau pyrido[2,3-d]pyrimidine a été développée, tout d

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García, Román Silvia. "Descubrimiento y evaluación biológica de un sistema pirido[2,3-d]pirimidínico como potencial pan-inhibidor para el tratamiento del cáncer de pulmón." Doctoral thesis, Universitat Ramon Llull, 2017. http://hdl.handle.net/10803/401388.

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El laboratori de síntesi del IQS presenta una amplia experiència en la síntesi de compostos heterocíclics amb estructura pirido[2,3-d]pirimidínica similars a les de diferents ITQs, l’ús dels quals està amplament estès com ibrutinib. Es van seleccionar 60 d’aquests compostos per ser estudiats enfront de 24 tirosina-quinases, dels quals en els 16 amb millors resultats es van iniciar els estudis biològics in vitro. Tres d’aquest compostos van resultar actius amb IC50 inferiors a 5 µM. No obstant, l’elevada toxicitat selectiva i la senzillesa sintètica d’un d’ells, van propiciar que el desenvolup

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Graf, Franziska. "Die Cyclin-abhängigen Kinasen 4 und 6 als Zielproteine für die Therapie und Bildgebung von Tumoren." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-38909.

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Die Cyclin-abhängigen Kinasen 4 und 6 (Cdk4/6) wurden als essentielle Enzyme für die Regulation des Zellzyklus mit kritischem Beitrag zur gestörten Zellproliferation während der Kanzerogenese identifiziert. Als Konsequenz davon erwiesen sich die Cdk4/6 als attraktive Zielproteine für die Entwicklung neuer therapeutischer Konzepte zur pharmakologischen Tumorbehandlung. Verbindungen aus der Substanzklasse der Pyrido[2,3-d]pyrimidine zeigten vielversprechende inhibitorische Wirkungen auf die Aktivität der Cdk4/6 bei gleichzeitiger herausragender Selektivität gegenüber anderen Cdk. Anschließende U

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Chang, Hsiu-chieh, and 張修絜. "Synthesis of Functionalized Benzo[d,d′]thieno[3,2-b;4,5-b′]dithiophenes (BTDTs) and Benzothieno[3,2-b]thieno[2’,3’:4,5]thieno[2,3-d] thiophene (B4T) for Organic Thin-Film Transistors." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/17246785565181579640.

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碩士<br>國立中央大學<br>化學研究所<br>98<br>Asymmetric molecules (1) and (6) were synthesized by “one-pot” reaction, and the yield of molecule (1) was improved. Four asymmetric molecules (2), (3), (4) and (5) based on molecule (1) had been developed. All of the molecules are P-type semiconductor materials. Molecule (2) exhibits good field-effect performance with a high mobility of 0.11 cm2 / Vs. In addition, the mobilities of molecule (3) and (4) are 0.088 and 0.08 cm2 / Vs. Soluble molecule (4) had been developed by attaching a long n-octyl chain to the end position and exhibits excellent field-effect per

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Lin, Chen-Wei, and 林振瑋. "Development of Furano[2,3-d]pyrimidine Compounds as Aurora Kinases Inhibitors." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/28168055795633623270.

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博士<br>國立清華大學<br>化學系<br>98<br>This dissertation is concerned with the development of furano[2,3-d]pyrimidine compounds as Aurora kinases inhibitors. Start from compound 1, we utilize rational drug design to synthesize two particular hits, compound 20 and 48. We analyze the co-crystal structures of two hits with Aurora-A, and observe the protein structures belong to DFG-out and DFG-out-like conformation. At the same time, we apply high-throughput parallel synthesis (HTPS) to accelerate the synthesis of analogues. Fortunately, we discover the lead compound 183 which was modified from compound 145

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Zhang, Xin. "Synthesis of Furo[2,3-d]Pyrimidines, Thieno[2,3-d]Pyrimidines, Pyrrolo[2,3-d]Pyrimidines as Classical and Nonclassical Antifolates, Receptor Tyrosine Kinase (RTK) Inhibitors and Antimitotic Agents." 2012. http://digital.library.duq.edu/u?/etd,154127.

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An introduction, background and research progress in the areas of antifolates, receptor tyrosine kinase (RTK) inhbitors and antimitotic agents has been discussed. <br>Thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFTase) are important folate dependent enzymes that are targets for cancer chemotherapy and the treatment of infectious diseases. Classical antifolates, in most cases, are substrates for folypoly-g-glutamate synthase (FPGS) and rely on folate transporter systems to enter cells. As a part of this study, twenty-eigh

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盧冠宇. "Synthesis and pharmacological evaluation of fused tricyclic thieno [2,3-d] pryimidine and quinazoline derivatives." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/53126416670356751342.

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Books on the topic "Thieno[2,3-d]pyrimidine"

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Scott, Andrew William. Preparation of fluorinated pyrrolo[2,3-d]pyrimidine. University of Birmingham, 1995.

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2

Pfleiderer, Mathias. Synthese und Eigenschaften 6-substituierter Pyrido[2,3-d]pyrimidine. Hartung-Gorre, 1986.

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Detmer, Monika. Zur Synthese dreikerniger Heterocyclen über neuartig substituierte Pyrido[2,3-d]pyrimidine. 2004.

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Book chapters on the topic "Thieno[2,3-d]pyrimidine"

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Caravatti, G., J. Brüggen, E. Buchdunger, et al. "Pyrrolo[2,3-d]pyrimidine and Pyrazolo[3,4-d]pyrimidine Derivatives as Selective Inhibitors of the EGF Receptor Tyrosine Kinase." In Anticancer Agents. American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2001-0796.ch014.

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Gangjee, A., J. Yang, J. J. McGuire, and R. L. Kisliuk. "Effect of Bridge Truncation of Classical 2,4-Diamino-5-Substituted Furo [2,3-d] Pyrimidine and 2-Amino-4-Oxo-6-Substituted Pyrrolo [2,3-d] Pyrimidine on Antifolate Activity." In Chemistry and Biology of Pteridines and Folates. Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0945-5_75.

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Gangjee, Aleem, Farahnaz Mavandadi, and Sherry F. Queener. "Synthesis and Biological Activity of Tricyclic, Conformationally Restricted Analogs of Lipophilic Pyrido[2,3-d]-Pyrimidine Antifolates." In Advances in Experimental Medicine and Biology. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2960-6_88.

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De Clercq, Erik. "Highly Potent and Selective Inhibition of Varicella–Zoster Virus Replication by Bicyclic Furo[2,3-d ]pyrimidine Nucleoside Analogues (BCNAs)." In Monographs in Virology. KARGER, 2006. http://dx.doi.org/10.1159/000096267.

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S. Laitonjam, Warjeet, and Nimalini Moirangthem. "Construction of Biologically Active Five- and Six-Membered Fused Ring Pyrimidine Derivatives from 1,3-Diarylthiobarbituric Acids (DTBA)." In Strategies Towards the Synthesis of Heterocycles and Their Applications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108842.

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Several derivatives of fused pyrimidines were synthesized in maximum yields by using the respective condensation products, namely, 5-ethoxymethylene-1,3-diaryl-2-thiobarbituric acids and 5-phenyl-methylene-1,3-diaryl-2-thiobarbituric acids, which can be obtained from 1,3-diarylthiobarbituric acids (DTBA). These condensation products possessing three electrophilic centres could undergo cyclocondensation with various binucleophiles to give various fused heterocycles of pyrimidine derivatives, such as pyrazolo[3,4-d]pyrimidine-6-thiones, 5,7-diaryl-4-oxo-isoxazolo[5,4-d]pyrimidine-6-thiones, 5-ox

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van der Westhuyzen, Aletta E., Liliya V. Frolova, Alexander Kornienko, and Willem A. L. van Otterlo. "The Rigidins: Isolation, Bioactivity, and Total Synthesis—Novel Pyrrolo[2,3- d ]Pyrimidine Analogues Using Multicomponent Reactions." In The Alkaloids: Chemistry and Biology. Elsevier, 2018. http://dx.doi.org/10.1016/bs.alkal.2017.12.003.

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Pałasz, Aleksandra, and Dariusz Cież. "10.6. Application of 2,4,6-Trioxo-pyrimidin-5-ylidene Alditol in the Synthesis of Pyrano[2,3-d]pyrimidine Containing a Sugar Moiety by Hetero-Diels–Alder Reaction." In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016. http://dx.doi.org/10.1039/9781849739634-00676.

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Conference papers on the topic "Thieno[2,3-d]pyrimidine"

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Stepochkina, Anna, Andrey Bakhtyukov, Kira Derkach, et al. "STEROIDOGENIC AND SPERMATOGENIC EFFECTS OF THIENO[2,3-d]-PYRIMIDINE-BASED ALLOSTERIC AGONIST OF LUTEINIZING HORMONE RECEPTOR IN MALE RATS WITH DIABETES MELLITUS." In XVIII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2022. http://dx.doi.org/10.29003/m2943.sudak.ns2022-18/327-328.

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Simijonović, Dušica, Edina Avdović, Žiko Milanović, Dejan Milenković, and Zoran Marković. "Green synthesis of chromeno-pyrimidine derivatives – Part I." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.686s.

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Two different chromeno-pyrimidine derivatives were synthetized in the ionic liquid catalyzed reaction of barbituric acid and substituted salicylaldehydes. The product 5-(7-bromo-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl)pyrimidine-2,4,6(1H,3H,5H)-tri-one (CP-1) was obtained in the reaction of barbiruric acid and 5-bromo-2-hydroxybenzaldehyde. The second new product 8,9-dihydroxy-2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione (CP-2) was yielded in the reaction between barbituric acid and 2,3,4-trihydroxybenzaldehyde. These products were isolated in moderate to good yield after 3

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Avdović, Edina, Dušica Simijonović, Žiko Milanović, Sandra Jovičić Milić, Sunčica Roca, and Dražen Vikić-Topić. "Chromeno-pyrimidine-type compounds (part II): in vitro evaluation of antioxidant potential." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.690a.

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The chromeno and pyrimidine classes compounds include a variety of hybrid molecules displaying diverse biological actions. Although they have been examined for many years, these compounds are still of interest due to their facile chemical transformations. The presence of chromeno and pyrimidine structural motifs in many drugs, prompted us to investigate the antioxidant features of compounds 5-(7-bromo-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl) pyrimidine-2,4,6(1H,3H,5H)-tri-one (CP-1) and 8,9- ihydroxy-2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione (CP-2). In this paper, we inv

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Ferreira, Marcelle de Souza, and José Daniel Figueroa Villar. "Synthesis of news furo[2,3-d] pyrimidine derivatives as potential inhibitors of DHFR." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013913121221.

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Tong, Nian, Aleem Gangjee, Adrianne Wallace Povrik, et al. "Abstract 5123: Targeted thieno[2,3-d]pyrimidines with fluorinated phenyl side chains as antitumor agents." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5123.

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Gangjee, Aleem, Farhana Islam, Tasdique Mohammad Quadery, Susan L. Mooberry, Anja Bastian, and Michael A. Ihnat. "Abstract 4837: Design, synthesis, and biological evaluation of thieno[2,3-d] and thieno[3,2-d]pyrimidines as dual acting RTK inhibitors and microtubule targeting antitumor agents." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4837.

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Stadlbauer, Wolfgang, and Dang Van Tinh. "Regioselective and Sequential Mono- and Diamination of 5,7-Dichloro-pyrido[2,3-d]pyrimidine-2,4-diones." In The 11th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2007. http://dx.doi.org/10.3390/ecsoc-11-01331.

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Maleki, Ali, Abbas Ali Jafari, Somayeh Yousefi, and Vahid Eskandarpour. "One-Pot Multicomponent Synthesis of Pyrano[2,3-d]Pyrimidine Derivatives Catalyzed by Supported Magnetic Nanoparticles." In The 18th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-a041.

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Tong, Nian, Aleem Gangjee, Adrianne W. Povrik, Carrie O. Connor, Jianjun Hou, and Larry Matherly. "Abstract 2798: Folate receptor-targeted cancer chemotherapy with novel 6-substituted thieno[2,3-d]pyrimidine compounds with nitrogen and fluorine containing aromatic side chains as de novo purine biosynthesis inhibitors." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2798.

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Wallace-Povirk, Adrianne, Nian Tong, Carrie O'Connor та ін. "Abstract 3983: Tumor-targeting with novel dual-targeted 6-substituted thieno[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α, and inhibition of de novo purine nucleotide biosynthesis". У Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3983.

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