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Relevant bibliographies by topics / Thio Pyrimidines

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Academic literature on the topic 'Thio Pyrimidines'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Thio Pyrimidines"

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Verma, Vishal, Chandra Prakash Joshi, Alka Agarwal, Sakshi Soni, and Udichi Kataria. "A Review on Pharmacological Aspects of Pyrimidine Derivatives." Journal of Drug Delivery and Therapeutics 10, no. 5 (2020): 358–61. http://dx.doi.org/10.22270/jddt.v10i5.4295.

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Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogens at positions 1 and 3 in the ring. Pyrimidines are typically synthesized by the “Principal Synthesis” involving cyclization of beta-dicarbonyl compounds with N-C-N compounds. Reaction of the former with amidines to give 2-substituted pyrimidines, with urea to give 2-pyrimidiones, and guanidines to give 2-aminopyrimidines are typical. Pyrimidines can be prepared via the biginelli reaction. Many other methods

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Ho, Yuh-Wen, and Maw Cherng Suen. "Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives." Journal of Chemistry 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/765243.

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A series of novel N-cycloalkanes, morpholine, piperazines, pyrazole, pyrimidine, benzimidazolo[1,2-a]pyrimidine, 1,2,3,4-tetrazolo[1,5-a]pyrimidine, azopyrazolo[1,5- a]pyrimidine, pyrimido[4', 5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives incorporating a 5-cyano-4-methyl-2-phenyl-(thio)pyrimidine moiety were obtained by the intramolecular cyclization of 6-methylthio-pyrimidine, 6-(benzoylmethyl)thio- pyrimidine and 2-[(5-cyano-4-methyl-2-phenylpyrimidin-6-yl)thio]-3-dimethyl- amino-1-phenyl-prop-2-en-1-one with appropriate amines and enaminone compounds, respectively. The structur

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Povidaichyk, M., О. Onysko, and M. Onysko. "SYNTHESIS OF TERMINAL 2-ALKENYL(ALKYNYL)THIO-5-CYANO-6-(p-DIMETHYLAMINOPHENYL)PYRIMIDIN-4-ONES." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 48, no. 2 (2023): 79–83. http://dx.doi.org/10.24144/2414-0260.2022.2.79-83.

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Functionalized pyrimidines possess a wide spectrum of biological activity. In particular, they have antitumor, antiviral, and anticonvulsant activities, exhibit anti-inflammatory and analgesic effects, and they are inhibitors of aldose reductase, SecA ATPase, azide, and plant growth. The search for methods of synthesis of new functionalized and condensed pyrimidine derivatives is an urgent problem. Alkenyl-functionalized mono- and polycyclic pyrimidines are promise substrates for studying the regioselectivity of electroph ilic heterocyclization reactions under the influence of halogen-co

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Ofitserova, Ekaterina S., Lilia N. Alekseeva, Artem A. Shklyarenko, and Igor P. Yakovlev. "Biological activity of new 6-[(1-naphthylmethyl)thio)]-4-chloropyrazolo[3,4-d]pyrimidines." Aspirantskiy Vestnik Povolzhiya 20, no. 1-2 (2020): 146–51. http://dx.doi.org/10.17816/2072-2354.2020.20.1.146-151.

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Topicality. This article presents the results of the study of the biological activity of newly synthesized 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines. The acute toxicity of 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines was determined experimentally on non-linear white male mice with a total weight of 1620 g. A generation model was used to experimentally evaluate the analgesic activity acetic writhing in male mice. It was experimentally confirmed that the new synthesized 6-[(1-naphthylmethyl)thio]-4-chloropyrazolo[3,4-d]pyrimidines were non-toxic and had prono

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Gorneva, Galina, Rada Mateva, Roumyana Gugova, and Evgeny Golovinsky. "The study of the apoptogenic effect of pyrimidine derivatives on murine leukemia cells." Archive of Oncology 13, no. 2 (2005): 62–64. http://dx.doi.org/10.2298/aoo0502062g.

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BACKGROUND: In the light of the recent findings concerning the role of apoptosis and of tumor cell enzymes in cancer chemotherapy, the interest in pyrimidine derivatives has greatly increased. Thio- and hydrazine- pyrimidines were synthesized as potential antimetabolites inhibiting the biosynthesis of nucleic acids. Some of them demonstrated biological activity, including antibacterial and antitumor action. The aim of this study was to analyze the cytotoxic activity and the ability of some derivatives to induce apoptosis in murine leukemia cells. METHODS: Exponentially growing cells were incub

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Zhylko, Vasyl, Lesya Saliyeva, Nataliia Slyvka, et al. "Synthesis, Antimicrobial and Antioxidant Activity of 3-Aryl-6,7-Dihydro-5H-[1,3]Thiazolo[3,2-a]Pyrimidines." Chemistry & Chemical Technology 19, no. 2 (2025): 250–58. https://doi.org/10.23939/chcht19.02.250.

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A series of 3-aryl-6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidines was obtained by cyclocondensation of tetrahydropyrimidin-2(1H)-one with 2-bromo-1-arylethanones. It was established that the nature of the substituent in the aromatic nucleus of phenacyl bromide significantly affects the course of this type of reaction. In particular, in the case of 2-bromo-1-(4-hydroxyphenyl)ethanone, the target bicyclic product is formed as a result of boiling in ethanol for 4 hours, whereas the reaction time for the cyclocondensation of tetrahydropyrimidine-2(1H)-thione with other bromomethylaryl ketones was

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Goyal, Ankush, Baljeet Kaur, Amandeep Kaur, Vivek K. Gupta, and Monika Gupta. "SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-(4-SUBSTITUTED BENZYLIDENE)- 7-METHYL-2H-THIAZOLO[3, 2-A] PYRIMIDINE-3,5-DIONES." INDIAN DRUGS 60, no. 07 (2023): 16–22. http://dx.doi.org/10.53879/id.60.07.12341.

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The organosulphur thiazolo-pyrimidines are fused heterocyclic compounds that can be anticipated as 7-thio counterparts of the genuine purine bases such as guanine and adenine. They have attained a growing significance in the domain of drug chemistry because of their diverse pharmacological activities. In the current study, 2-substituted benzylidene-7-methyl-2H-thiazolo [3,2-a] pyrimidine-3,5-dione derivatives were synthesised. The synthetic compounds were tested against the human myelomonocytic leukaemia cell line (U-937) for their ability to inhibit cancer cell growth as well as against Gram

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Al-Omran, Fatima, and Adel A. El-Khair. "Studies with 2-(acetonylthio)benzothiazole. New routes to isoxazoles, isoxazolo[3,4-b]pyridines, pyrazolo[1,5-a]pyrimidines, pyridines and quinolizines." Journal of Chemical Research 2009, no. 7 (2009): 433–36. http://dx.doi.org/10.3184/030823409x464412.

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Derivatives of isoxazole, isoxazolo[3,4- b]pyridine, pyrazolo-[1,5- a]pyrimidine and pyridin-2(1 H)-one incorporating a benzothiazole-2-thio residue have been synthesised. The structures of these newly synthesised compounds are characterised by elemental analysis, IR, 1H and 13C NMR, NOE and MS.

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Gabrielsen, B., J. J. Kirsi, C. D. Kwong, et al. "In vitro and in vivo antiviral (RNA) evaluation of orotidine 5′-monophosphate decarboxylase inhibitors and analogues including 6-azauridine-5′-(ethyl methoxyalaninyl)phosphate (a 5′-monophosphate prodrug)." Antiviral Chemistry and Chemotherapy 5, no. 4 (1994): 209–20. http://dx.doi.org/10.1177/095632029400500402.

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A series of 29 pyrimidines comprising analogues of 6-azauridine (e.g. 2- and 4-thio-6-azauridine), 6-substituted uridines (including several known inhibitors of orotidine 5′-monophosphate decarboxylase, ODCase, e.g. pyrazofurin), and 6-azauridine-5′-(ethyl methoxyalaninyl) phosphate (a potential prodrug of 6-AU-5′-MP) were synthesized and evaluated in vitro and in vivo against five RNA viruses: Japanese encephalitis (JE), yellow fever (YF), sandfly fever (SF), Punta Tora (PT) and Venezuelan equine encephalomyelitis (VEE) viruses. 2-Thio-6-azauridine demonstrated the best In vitro activity agai

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Held, Heike A., Abhijit Roychowdhury, and Steven A. Benner. "C-5 Modified Nucleosides: Direct Insertion of Alkynyl-Thio Functionality in Pyrimidines." Nucleosides, Nucleotides & Nucleic Acids 22, no. 4 (2003): 391–404. http://dx.doi.org/10.1081/ncn-120022030.

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Dissertations / Theses on the topic "Thio Pyrimidines"

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Leidenberger, Kerstin. "NMR-spektroskopische und strukturelle Untersuchungen zur Wechselwirkung von Organometallfragmenten mit Pyrimidin-Nukleotiden und Thio-Nukleobasen." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960208763.

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Le, Hir de Fallois Loic. "Synthèse et étude de nucléosides et nucléotides inhibiteurs de la ribonucléotide réductase." Université Joseph Fourier (Grenoble), 1995. http://www.theses.fr/1995GRE10158.

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La ribonucleotide reductase (rnr) est l'enzyme qui catalyse la reduction des ribonucleotides en desoxyribonucleotides. En raison de son role fondamental dans la synthese de l'adn, cette enzyme est une cible cle de la recherche de nouveaux agents antitumoraux. Dans le but d'inhiber cette enzyme nous avons synthetise des analogues de substrats. Nous avons synthetise et etudie les proprietes des premiers nucleosides thionitrites, les 2'-desoxy-2'-s-nitroso-uridine et -cytidine. Nous avons demontre que ces thionitrites liberent du monoxyde d'azote (no) qui est un inhibiteur de la ribonucleotide re

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Leidenberger, Kerstin [Verfasser]. "NMR-spektroskopische und strukturelle Untersuchungen zur Wechselwirkung von Organometallfragmenten mit Pyrimidin-Nukleotiden und Thio-Nukleobasen / vorgelegt von Kerstin Leidenberger." 2000. http://d-nb.info/960208763/34.

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Books on the topic "Thio Pyrimidines"

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Eland, John H. D., and Raimund Feifel. Conjugated and aromatic molecules. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198788980.003.0006.

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In the vast majority of conjugated and aromatic molecules, the outermost occupied orbitals are either of π‎ character or non-bonding lone pairs belonging to heteroatoms. These are the orbitals from which double ionisation gives rise to most of the distinct bands that can be discerned in their spectra. Double photoionisation spectra of ethylene, butadiene, pyrrole, furan, thiophene, benzene, hexafluorobenzene, toluene, pyridine, pyrazine, pyrimidine, pyridazine, naphthalene, azulene, quinoline, biphenyl, TDME, iron pentacarbonyl, ferrocene, and TMPPD are presented with analysis where possible.

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Book chapters on the topic "Thio Pyrimidines"

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Wadman, S. K., P. K. de Bree, M. Duran, and H. Fabery de Jonge. "Detection of Inherited Adenylosuccinase Deficiency by Two Dimensional Thin Layer Chromatography of Urinary Imidazoles." In Purine and Pyrimidine Metabolism in Man V. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5104-7_3.

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Liu, Wei, Xiaoli Wu, Zheng Gao, and Lingling Xia. "Minimally Invasive Technologies for Treatment of HTS and Keloids: Low-Dose 5-Fluorouracil." In Textbook on Scar Management. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_30.

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AbstractBoth hypertrophic scar (HTS) and keloid are pathological scars that tend to overgrow and overproduce extracellular matrices, lead to large-sized scars along with severe pain and itching, and even result in functional disability. In particular, keloids are considered as benign skin tumors due to their nature of uncontrolled growth beyond the original wound boundary and invasion into normal skin; therefore, anticancer therapy has been employed in keloid therapy. 5-Fluorouraci (5-FU), a pyrimidine analog, is a commonly used chemotherapy agent and it has also been previously used in keloid

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Davies, David T. "Pyrimidines." In Aromatic Heterocyclic Chemistry. Oxford University Press, 1992. http://dx.doi.org/10.1093/hesc/9780198556602.003.0010.

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This chapter explores pyrimidines. Formal replacement of a CH unit in pyridine by a nitrogen atom leads to the series of three possible diazines: pyridazine, pyrimidine, and pyrazine. Like pyridine, they are fully aromatic heterocycles. The effect of an additional nitrogen atom as compared to pyridine accentuates the essential features of pyridine chemistry. Electrophilic substitution is difficult in simple unactivated diazines because of both extensive protonation under strongly acidic conditions and the inherent lack of reactivity of the free base. Nucleophilic displacements are comparativel

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Najajreh, Yousef, and Maha Awwad Khoury. "Synthetic Approaches for Pharmacologically Active Decorated Six-Membered Diazines." In Strategies Towards the Synthesis of Heterocycles and Their Applications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.109103.

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Diazine alkaloid (pyridazine, pyrimidine and pyrazine) scaffold, a widespread two-nitrogen containing compounds in nature (DNA, RNA, flavors, and fragrances), constitutes a central building block for wide range of pharmacological applications. Diazines are reported to exhibit antimetabolite (antifolate and), anticancer, antibacterial, antiallergic, tyrosine kinase, antimicrobial, calcium channel antagonistic, anti-inflammatory, analgesic, antihypertensive, antileishmanial, antituberculostatic, anticonvulsant, diuretic and potassium-sparing, to antiaggressive activities. Pyridazine (1,2-diazine

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Nath Singh, Dina, and Nisha Verma. "Pharmaceutical Potential of Pyrimidines as Antiviral Agents." In Frontiers in Medicinal Chemistry. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815165043123100006.

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Antiviral drugs are a class of medicines particularly used for the treatment of viral infections. Drugs that combat viral infections are called antiviral drugs. Viruses are among the major pathogenic agents that cause a number of serious diseases in humans, animals and plants. Viruses cause many diseases in humans, from self-resolving diseases to acute fatal diseases. The strategies for the development of antiviral drugs are generally focused on two different approaches, i.e., targeting the viruses themselves or the host cell factors. Antiviral drugs that directly target viruses include the in

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Marinaki, Anthony M., Lynette D. Fairbanks, and Richard W. E. Watts. "Disorders of purine and pyrimidine metabolism." In Oxford Textbook of Medicine, edited by Timothy M. Cox. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0230.

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Disorders of purine and pyrimidine metabolism are due to abnormalities in the biosynthesis, interconversion, and degradation of the purines—adenine and guanine—and of the pyrimidines—cytosine, thymine, and uracil. The purine nucleotides, their cyclic derivatives (cAMP and cGMP), and their more highly phosphorylated derivatives have functions in many aspects of intermediary metabolism. Purine compounds also function as signal transducers, neurotransmitters, vasodilators, and mediators of platelet aggregation. Disorders of purine metabolism—the end point of purine metabolism in humans is uric ac

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Ude, Arinzechukwu, and Kelechi Okeke. "Leukaemia: The Purinergic System and Small Extracellular Vesicles." In Purinergic System [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104326.

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Haematopoiesis is a tightly regulated process, by intrinsic and extrinsic factors, to produce lifelong blood cell lineages within the bone marrow. In the bone marrow microenvironment, mesenchymal stem cells and haematopoietic stem cells play important roles to ensure that haematopoiesis is maintained. These cells contain purines and pyrimidines that control intercellular process such as energy transport. However, in some cases, this process may be misregulated thus leading to the production of various diseases, including leukaemia. As a result, bone marrow cells may be stimulated via stress or

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Milano, Gerard, and Jan H. M. Schellens. "Pyrimidine antimetabolites." In Cancer Clinical Pharmacology. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780192629661.003.0005.

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Abstract Antimetabolites have structural similarities with intermediates of normal metabolism and they interact with the synthesis of RNA and DNA precursors.In the majority of cases antimetabolites are enzyme substrates and act by inhibiting enzymes which are essential for RNA and DNA synthesis. Alternatively, antimetabolites may be cytotoxic because of their incorporation into nucleic acids; this is well characterized

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"Purines and Pyrimidines: Essential Nitrogen Heterocycles." In The Chemical Biology of Carbon. The Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781839169502-00205.

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This is the first of three chapters on biologic heterocycles as central chemical and metabolic building blocks. This chapter focuses specifically on the pyrimidine and purine building blocks for RNA and DNA. The four functional groups of amides, amidines, ureas, and guanidines dictate the hydrogen bonding rules for Watson–Crick base pairing in double helical DNA. The biosynthetic logic for both the monocyclic pyrimidine nucleotides, uridine monophosphate and cytidine triphosphate, and the bicyclic purines, adenosine monophosphate, and guanosine monophosphate, are evaluated based on simple meta

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"Major Classes of Natural Product Scaffolds and Enzymatic Biosynthetic Machinery." In Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery. The Royal Society of Chemistry, 2017. http://dx.doi.org/10.1039/bk9781788010764-00006.

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This opening chapter introduces the major structural classes of small molecule natural products: polyketides, peptides, isoprenoids, alkaloids, purines/pyrimidines, and phenylpropanoids. Each class is assembled with distinct chemical logic and dedicated biosynthetic enzymes that convert primary metabolic building blocks into complex secondary metabolite mature product scaffolds.

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Conference papers on the topic "Thio Pyrimidines"

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Hoshowski, Jody, Paul Barnes, Rolando Perez Pineiro, Alyn Jenkins, and Tore Nordvik. "The Development of Novel Corrosion Inhibitors for High Temperature Sour Gas Environments." In CORROSION 2020. NACE International, 2020. https://doi.org/10.5006/c2020-14591.

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Abstract Mitigating oil and gas production with chemical inhibitors is challenging when high temperature (&gt;120°C) and H2S is present. The high temperatures associated with deep wells and thermal recovery methods demand an advancement in conventional inhibitor technologies. Traditional organic inhibitors struggle to protect carbon steel assets lending them susceptible to localized corrosion in sour environments. These environments require inhibitors with a combined thermal stability and persistency to provide uniform filming and corrosion protection. For high temperature corrosion applic

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He, Yi, Shuai Ren, Xi Wang, et al. "The Effect of Temperature on the Adsorption Behavior and Inhibition Performance of a Pyrimidine-Type Inhibitor at Medium Temperature Range (25°C to 80°C)." In CONFERENCE 2022. AMPP, 2022. https://doi.org/10.5006/c2022-17895.

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Abstract In the oil and gas industry, long-distance transmission of produced hydrocarbons is usually carried out in large-diameter steel pipelines. However, water co-produced with the oil and gas, combined with CO2 or H2S, can cause severe corrosion of internal pipeline surfaces. A widely applied, economically effective method of corrosion control is to inject corrosion inhibitors (CIs). Adsorption of the organic molecules on surfaces through heteroatom functionalities, containing nitrogen, oxygen, sulfur and/or phosphorus, can markedly change the corrosion resistance characteristics of the ex

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Avdović, Edina, Dušica Simijonović, Žiko Milanović, Sandra Jovičić Milić, Sunčica Roca, and Dražen Vikić-Topić. "Chromeno-pyrimidine-type compounds (part II): in vitro evaluation of antioxidant potential." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.690a.

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The chromeno and pyrimidine classes compounds include a variety of hybrid molecules displaying diverse biological actions. Although they have been examined for many years, these compounds are still of interest due to their facile chemical transformations. The presence of chromeno and pyrimidine structural motifs in many drugs, prompted us to investigate the antioxidant features of compounds 5-(7-bromo-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl) pyrimidine-2,4,6(1H,3H,5H)-tri-one (CP-1) and 8,9- ihydroxy-2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione (CP-2). In this paper, we inv

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Deng, Jiac Hun, Na Jin, Zhong Qiang Wang, Shou Gen Yin, and Yu Lin Hua. "Organic Field Effect Transistors with Polarizable Active Layer of 2-(4-Hydroxyphenyl)-5-Pyrimidinol Thin Film." In 2008 2nd International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2008. http://dx.doi.org/10.1109/icbbe.2008.240.

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Shutalev, Anatoly, Anastasia Fesenko, and Natalia Lonina. "Synthesis of 5-R-thio, 5-R-sulfinyl, 5-R-sulfonyl and 5-di(R-oxy)phosphoryl Substituted Hydrogenated Pyrimidine-2-thiones/ones." In The 8th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2004. http://dx.doi.org/10.3390/ecsoc-8-01943.

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