Relevant bibliographies by topics / Thiohydantoin

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Thiohydantoin'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Thiohydantoin"

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CHACÓN, C., J. A. HENAO, J. JAMALIS, P. RIVAS, W. VELÁSQUEZ, and G. E. DELGADO. "SYNTHESIS, CRYSTAL STRUCTURE AND HIRSHFELD SURFACE ANALYSIS OF 1-ACETYL-5-(2-METHYLPROPYL)-2-THIOXO-IMIDAZOLIDIN- 4-ONE." Periódico Tchê Química 15, no. 29 (2018): 292–99. http://dx.doi.org/10.52571/ptq.v15.n29.2018.292_periodico29_pgs_292_299.pdf.

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The hydantoin and thiohydantoin heterocycles are present in a wide range of biologically active compounds including therapeutic drugs for the treatment of seizures and anti-tumor compounds. Thiohydantoins, have also been used as anti-convulsant agents and are present in fungicides, herbicides and natural products. However, the principal current interest comes from the application of thiohydantoins for the treatment of prostate cancers. Structural characterization of hydantoin and thiohydantoin are important to comprehend their effect mechanisms because of their considerable biological effects.
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Kobelev, Aleksandr I., Nikita A. Tretyakov, Ekaterina E. Stepanova, Maksim V. Dmitriev, Michael Rubin, and Andrey N. Maslivets. "Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea." Beilstein Journal of Organic Chemistry 15 (November 27, 2019): 2864–71. http://dx.doi.org/10.3762/bjoc.15.280.

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A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin–thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without applying preparative chromatography methods.
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Allegretti, Patricia E., M. de las Mercedes Schiavoni, Celia Guzmán, Agustín Ponzinibbio, and Jorge J. P. Furlong. "Mass Spectral Study of the Occurrence of Tautomeric Forms of Thiohydantoins." European Journal of Mass Spectrometry 13, no. 4 (2007): 291–306. http://dx.doi.org/10.1255/ejms.885.

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Mass spectrometry is used to evaluate the occurrence of thio-enol structures among the several possible tautomers of thiohydantoins and dithiohydantoins. Mass spectra of differently-substituted thiohydantoins are examined looking for common mass spectral behaviors to be predicted. Ion fragmentations from specific tautomers allow the most stable thio-enol structure for both type of compounds. The mass spectrum of the alkylation product of 5,5-dimethyldithiohydantoin and the nuclear magnetic resonance spectra of the alkylation products of both 2-thiohydantoin and dithiohydantoin support the fact
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Zhang, Ranran, Junhong Liu, Hui Yan, Xingrong Peng, Ling Zhang, and Minghua Qiu. "Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)." Molecules 26, no. 16 (2021): 4934. http://dx.doi.org/10.3390/molecules26164934.

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Five new thiohydantoin derivatives (1–5) were isolated from the rhizomes of Lepidium meyenii Walp. NMR (1H and 13C NMR, 1H−1H COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds. Significantly, the structure of compound 1 was the first example of thiohydantoins with thioxohexahydroimidazo [1,5-a] pyridine moiety. Additionally, compounds 2 and 3 possess rare disulfide bonds. Except for compound 4, all isolates were assessed for neuroprotective activities in corticosterone (CORT)-stimulated PC12 cell damage. Among them, compound (−)-3 exhibited mo
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A. Gotmare, Prashant, and Sanjay V. Kolhe. "Design of Novel Thiohydantoin Derivatives and Exploration their Physico-Chemical Parameters." Oriental Journal Of Chemistry 39, no. 5 (2023): 1264–71. http://dx.doi.org/10.13005/ojc/390520.

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Thiohydantoin analogues was heterocyclic non-aromatic five membered cyclic compounds obtained from aurones derivatives. In this article, we synthesized novel thiohydantoin derivatives and exploration of physicochemical parameters like density, viscosity, ultrasonic velocity, intermolecular free path, adiabatic compressibility etc. The structural elucidation of resultant compounds was done on the basis 1HNMR, IR, Mass etc. The present study revealed that, thiohydantoin analogues shows more structure making capacity in DMSO than DMF.
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Casagranda, F., BM Duggan, A. Kirkpatrick, RL Laslett, and JFK Wilshire. "Studies in Thiohydantoin Chemistry. II. C-Terminal Sequencing of Peptides." Australian Journal of Chemistry 49, no. 5 (1996): 551. http://dx.doi.org/10.1071/ch9960551.

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An investigation has been carried out into the thiocyanate degradation (AcOH/Ac2O/HSCN) procedure as it relates to the C-terminal sequencing of peptides, particular emphasis being placed on the sequencing of amino acid residues containing sensitive or functional side chains. Attempted C-terminal sequencing of several serine- and threonine -containing peptides stopped at these particular residues, and did not proceed further. It is concluded that sequencing of most of the common amino acids is achievable but that significant problems will have to be overcome before routine sequencing of proline
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Cejpek, K., and J. Velíšek. "Advances in Chemistry of Isothiocyanate-derived Colourants." Czech Journal of Food Sciences 27, Special Issue 1 (2009): S207—S210. http://dx.doi.org/10.17221/1092-cjfs.

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This study is focused on the reactions of isothiocyanates (ITCs) in the presence of amino compounds leading to coloured structures <I>via</I> substituted 2-thiohydantoins. A series of complementary experiments has been done and appropriate reaction conditions and structural prerequisites have been defined. Low-molecular colourants isolated and characterised from the model systems can be sorted into three groups. Yellow to red diastereomeric dehydrodimers of 2-thiohydantoin derivatives that contain an acidic methylene group are formed in mixtures consisted of ITCs and amino acids wi
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Stanic, Petar, Marko Rodic, Tanja Soldatovic та ін. "Reaction of a 3-aryilidene-2-thiohydantoin derivative with polymeric trans-[CuCl2(DMSO)2]n complex: Unexpected isomerization to dinuclear cis-[{CuCl(DMSO)2}(μ-Cl)]2". Journal of the Serbian Chemical Society, № 00 (2020): 60. http://dx.doi.org/10.2298/jsc200917060s.

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The 3-arylidene-2-thiohydantoin derivative, 3-[(2-hydroxybenzyl-idene)amino]-2-thioxoimidazolidin-4-one, was synthesized in a two-step condensation reaction of 2-hydroxybenzaldehyde, thiosemicarbazide and ethyl chloroacetate. The ligand was structurally characterized by NMR and IR spectroscopy, as well as elemental analysis. In the reaction of the well-known polymeric trans-[CuCl2(DMSO)2]n complex with the polydentate thiohydantoin type ligand, instead of the corresponding copper thiohydantoin complex, unexpectedly, the dinuclear cis-[{CuCl(DMSO)2}(m-Cl)]2 complex (1) was formed predominantly
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Jakše, Renata, David Bevk, Amalija Golobič, Jurij Svete та Branko Stanovnik. "Synthesis and Transformations of Ethyl 3-Formyl-1H-indole-2-carboxylate. Preparation of Aplysinopsin and β-Carboline Thiohydantoin Analogues". Zeitschrift für Naturforschung B 61, № 4 (2006): 413–19. http://dx.doi.org/10.1515/znb-2006-0407.

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Various aplysinopsin and β -carboline thiohydantoin analogues were prepared starting from ethyl 3-formyl-1H-indole-2-carboxylate by condensation with the active methylene group of 2-thiohydantoin, rhodanine, or thiobarbituric acid derivatives
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Stanić, Petar, Marija Živković, and Biljana Šmit. "Synthesis and Characterization of Various Amino Acid Derived Thiohydantoins." Proceedings 9, no. 1 (2018): 37. http://dx.doi.org/10.3390/ecsoc-22-05690.

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Hydantoins and their sulfur containing analogues, thiohydantoins, are cyclic ureides that have attracted huge attention ever since their discovery. Most of them are biologically active compounds and several points of structural diversity have made them very synthetically attractive. Although substituents can be introduced to the hydantoin nucleus, most substituted hydantoins are synthesized from substrates already containing these groups, while forming the hydantoin nucleus. This is a common route to the synthesis of hydantoins and one of them is employed in this study. A series of 3-allyl-2-t
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Dissertations / Theses on the topic "Thiohydantoin"

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Gosling, Sandrine. "Synthèse et fonctionnalisation de 2-thiohydantoïnes : interaction et inhibition des nucléosides monophosphate kinases." Thesis, Orléans, 2011. http://www.theses.fr/2011ORLE2028/document.

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La découverte de nouvelles substances thérapeutiques nécessite la synthèse de série de molécules soumises au criblage biologique sur une cible donnée. Ce projet de recherche a pour objectif de développer des inhibiteurs de nucléosides monophosphate kinases (NMPK) en se basant sur le concept de chimie dynamique combinatoire in situ. La synthèse de ces molécules a nécessité l’association via des fonctions réactives d’un analogue d’accepteur de phosphate et d’un mime d’ATP donneur de phosphate. La mise au point de ce dernier a fait l’objet de ce travail de thèse et a été orientée vers la pharmaco
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PINTO, FILHO Francisco. "Desenvolvimento e caracterização de nanopós obtidos por complexação de lantanídeos com tio-hidantoína e 1,10’ fenantrolina." Universidade Federal de Campina Grande, 2016. http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/973.

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Submitted by Emanuel Varela Cardoso (emanuel.varela@ufcg.edu.br) on 2018-06-13T19:56:21Z No. of bitstreams: 1 FRANCISCO PINTO FILHO – TESE (PPGEP) 2016.pdf: 2405186 bytes, checksum: d7b5b1d68600f138fc5134159b39d6fc (MD5)<br>Made available in DSpace on 2018-06-13T19:56:21Z (GMT). No. of bitstreams: 1 FRANCISCO PINTO FILHO – TESE (PPGEP) 2016.pdf: 2405186 bytes, checksum: d7b5b1d68600f138fc5134159b39d6fc (MD5) Previous issue date: 2016-08-29<br>Capes<br>A busca por inovações tecnológicas nos últimos anos cada vez mais se intensifica. Neste contexto, dois importantes grupos, os lantanídeos e
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Karmakar, S. "Synthetic studies towards pseudotheonamides, herbarium III, bicyclic thiohydantoins and oxazolidinone -5- one." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2006. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2479.

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Moraes, Aline Pereira. "Alcaloides indólicos das partes aéreas de psychotria sp.(rubiaceae) e síntese de tiohidantoínas e tioureias derivadas de aminoácidos e do r-(+)-limoneno." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3316.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2014-10-09T15:01:20Z No. of bitstreams: 2 Dissertação - Aline Pereira Moraes - 2013.pdf: 2375025 bytes, checksum: edebdd82c526094db969a19e855e1017 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2014-10-09T15:30:41Z (GMT) No. of bitstreams: 2 Dissertação - Aline Pereira Moraes - 2013.pdf: 2375025 bytes, checksum: edebdd82c526094db969a19e855e1017 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Ma
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Ahmad, Hiwa Omer. "Kinetics and mechanism of racemisation reactions of configurationally labile stereogenic centres in drug-like molecules in aqueous solutions : thiohydantoins and related compounds." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/78387/.

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In this thesis, studies of the kinetic and mechanism of racemisation of several drug-like molecule have been presented. Chapter 1 provides background information on the general mechanisms of racemisation of drugs in general, and hydantoin derivatives. In particular including reviews of the hydrolysis and the mechanism of base-catalysed racemisation of hydantoin derivatives. The synthesis of different chiral hydantoins, thiohydantoins, thiazolidine-diones, and rhodanines is presented in Chapter 2. Several enantio-enriched 5-substituted 1-acetyl-2-thiohydantoins and two tri-substituted 2-thiohyd
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Shih, Chun-Ru, and 施純如. "The anti-proliferation effect of 5,5-Diphenyl-2-thiohydantoin ( SDil-1 ) in human vascular endothelial cells." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/35257283860651709099.

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碩士<br>台北醫學院<br>醫學研究所<br>90<br>The aim of this study is to examine the antiproliferation effect of SDil-1 （5,5-Diphenyl-2-thiohydantoin）in human umbilical vein endothelial cells （HUVEC）and its possible underlying mechanism. Our data demonstrated that SDil-1 caused an inhibition in HUVEC proliferation. The result of 3H-Thymidine incorporation showed that SDil-1 decreased DNA synthesis in HUVEC. Flow cytometric analysis demonstrated that treatment of HUVEC with SDil-1 arrested the cell at the G0/G1 phase of the cell cycle. Western blot analysis showed that treatment of HUVEC with SDil-1 for 21h i
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Lee, Tong-Sheng, and 李東昇. "The Anti-Proliferation Effect of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10) in Human Colon Cancer Cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/26577121329226167745.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>97<br>5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10) is a synthetic derivative compound of anti-epileptic medicine phenytoin (5,5-diphenylhydantoin). Previously, we have shown that DPTH-N10 exerts an anti-angiogenesis activity. The aim of this study is to study the anti-proliferation effect of DPTH-N10 in colon cancer cells and its molecular mechanisms underlying. [3H]-Thymidine incorporation analysis demonstrated that DPTH-N10 at a range of concentrations (10-30 ?嵱) dose-dependently inhibited DNA synthesis in human colon cancer cell line (COLO-205). Western blot an
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Lin, Yen-Tzu, and 林彥慈. "One-Pot, Three-Component Regioselective Synthesis of 2-Iminothiazole and 2-Thiohydantoin and One-pot Synthesis of 5-Imino-1, 2, 4-Thiadiazole with Iodine as S-N Bond Forming Reagent." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/s87rtg.

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Book chapters on the topic "Thiohydantoin"

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Dupont, David R., MeriLisa Bozzini, and Victoria L. Boyd. "The alkylated thiohydantoin method for C-terminal sequence analysis." In Proteomics in Functional Genomics. Birkhäuser Basel, 2000. http://dx.doi.org/10.1007/978-3-0348-8458-7_8.

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Dupont, David R., Sylvia W. Yuen, and Kenneth S. Graham. "Automated C-Terminal Protein Sequence Analysis Using the Alkylated-Thiohydantoin Method." In Protein Sequencing Protocols. Humana Press, 2003. http://dx.doi.org/10.1385/1-59259-342-9:319.

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Inglis, Adam S., and Claudio De Luca. "A New Chemical Approach to C-Terminal Microsequence Analysis via the Thiohydantoin." In Methods in Protein Sequence Analysis. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4899-1603-7_9.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of nickel(II) acetato complex with 5-(phenylazo)-2-thiohydantoin." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 3. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62470-8_21.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) acetato complex with 5-(phenylazo)-2-thiohydantoin." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 4. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62474-6_72.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of dicopper(II) chloro complex with 5-(phenylazo)-2-thiohydantoin." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 4. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62474-6_196.

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Wang, Zerong. "Thiohydantoins." In Amino Acids: Insights and Roles in Heterocyclic Chemistry. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003329831-3.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of nickel(II) acetato complex with 5-(2-hydroxy-phenylazo)-2-thiohydantoin." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 3. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62470-8_22.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) chloro complex with 5-(2-hydroxy-phenylazo)-2-thiohydantoin." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 4. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62474-6_64.

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Pardasani, R. T., and P. Pardasani. "Molar magnetic moment of cobalt(II) acetato complex with 5-(2-hydroxy-phenylazo)-2-thiohydantoin." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 2. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62466-1_206.

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Conference papers on the topic "Thiohydantoin"

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Dovichi, Norman J., Shade Wu, and Da Yung Chen. "High Sensitivity Fluorescence Detection of Biological Molecules." In Laser Applications to Chemical Analysis. Optica Publishing Group, 1990. http://dx.doi.org/10.1364/laca.1990.tha1.

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Fluorescein is a good fluorescent label for high sensitivity analysis. The molecule has high molar absorptivity, 5 × 104 L mol-1 cm-1 at 488 nm and near unit fluorescence quantum yield in the pH range of 8 to 10. Unfortunately, the molecule is not photostable undergoing irreversible photobleaching after absorbance of about 8,000 photons. Fluorescein may be used to label amino groups in amino acids, peptides, and proteins through the isothiocyanate derivative. Under basic conditions, the thiocarbamoyl derivative is formed, with relatively good stability. The reaction between amino acids and flu
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Stanić, Petar, Darko Ašanin, Marijana Vasić, Tanja Soldatović, and Biljana Šmit. "KINETICS OF THE REACTION OF AN ARYLIDENE 2-THIOHYDANTOIN DERIVATIVE WITH SOME Pd(II) COMPLEXES." In 1st INTERNATIONAL SYMPOSIUM ON BIOTECHNOLOGY. University of Kragujevac, Faculty of Agronomy, 2023. http://dx.doi.org/10.46793/sbt28.497s.

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Reactions of 3-(benzylideneamino)-2-thioxoimidazolidin-4-one with some palladium complexes (PdCl2, Pd(DMSO)2Cl2 and K2PdCl4) were monitored with NMR spectroscopy, which is used as a convenient and practical tool for determining the kinetic parameters of the reactions. Rate constants of the reactions were determined and reactivity of the complexes towards the 2-thiohydantoin derivative was compared.
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El Fattah, M. E. Abd, H. H. Abd Allah, and A. H. Soliman. "Synthesis and Study of the Biological Activity of Some New Thiohydantoin Derivatives." In The 14th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00494.

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Stanić, Petar B., Biljana Šmit, Jovana Muškinja, et al. "Normal and Reversed Phases Thin-Layer Chromatography of Arylidene 2- Thiohydantoin Derivatives." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.531s.

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In this paper, the retention behavior of thirteen newly synthesized arylidene derivatives of 2-hydamthione was investigated by normal and reversed phases thin-layer chromatography. In normal phase chromatography, thin layers of silica gel and cyano-propyl (CN) silica gel with fluorescent indicator F254 were used as the stationary phase. As the mobile phase, binary systems of non-aqueous solvents benzene-ethyl acetate and hexane-ethyl acetate were used, 8:2 (v/v). Reversed phase chromatography was performed using a thin layer of octadecyl (C-18) silica gel with fluorescent indicator F254 as the
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Stanić, Petar, Nataša Vukićević, Vesna Cvetković, Miroslav Pavlović, Silvana Dimitrijević, and Biljana Šmit. "ELECTROCHEMICAL INVESTIGATION OF 2-THIOHYDANTOIN DERIVATIVES AS CORROSION INHIBITORS FOR MILD STEEL IN ACIDIC MEDIUM." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.157s.

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Four 2-thiohydantoin derivatives were synthesized and their corrosion inhibition properties on mild steel (MS) in 0.5M HCl solution was evaluated using usual gravimetric and electrochemical methods (weight loss, potentiodynamic polarization, electrochemical impedance spectroscopy (EIS). Morphology of the metal surface was characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The study has shown that these compounds provide good protection for mild steel against corrosion in the acidic medium.
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Abidiy, Syafri Izzat, Triyanda Gunawan, Yusuf Syahril Alam, et al. "Antiviral activity of hydrazone derivatives based benzohydrazide/2-thiohydantoin analogs against HPV-18 (Human papillomavirus) : In silico study." In THE FOURTH AL-NOOR INTERNATIONAL CONFERENCE FOR SCIENCE AND TECHNOLOGY (4NICST2022). AIP Publishing, 2024. http://dx.doi.org/10.1063/5.0206875.

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Smit, Biljana, Petar Stanic, Marija Zivkovic, Zoran Ratkovic, and Jovana Muskinja. "Thiohydantoins from vanillin and its derivatives - Synthesis and Characterization." In The 23rd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecsoc-23-06656.

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Smit, Biljana, Petar Stanic, Marija Zivkovic, Zoran Markovic, and Dejan Milenkovic. "Formation of amino acid derived 2-thiohydantoins - An experimental and theoretical study." In The 23rd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecsoc-23-06696.

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Mishra, Anamika, Vineet Gupta, Poonam Tandon, Ko-Ki Kunimoto, P. M. Champion, and L. D. Ziegler. "Vibrational Spectroscopy and Density Functional Theory of Intermolecular Hydrogen Bonding in 2-Thiohydantoins." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482568.

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