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Journal articles on the topic 'Thiohydantoin'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

CHACÓN, C., J. A. HENAO, J. JAMALIS, P. RIVAS, W. VELÁSQUEZ, and G. E. DELGADO. "SYNTHESIS, CRYSTAL STRUCTURE AND HIRSHFELD SURFACE ANALYSIS OF 1-ACETYL-5-(2-METHYLPROPYL)-2-THIOXO-IMIDAZOLIDIN- 4-ONE." Periódico Tchê Química 15, no. 29 (2018): 292–99. http://dx.doi.org/10.52571/ptq.v15.n29.2018.292_periodico29_pgs_292_299.pdf.

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The hydantoin and thiohydantoin heterocycles are present in a wide range of biologically active compounds including therapeutic drugs for the treatment of seizures and anti-tumor compounds. Thiohydantoins, have also been used as anti-convulsant agents and are present in fungicides, herbicides and natural products. However, the principal current interest comes from the application of thiohydantoins for the treatment of prostate cancers. Structural characterization of hydantoin and thiohydantoin are important to comprehend their effect mechanisms because of their considerable biological effects.

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2

Kobelev, Aleksandr I., Nikita A. Tretyakov, Ekaterina E. Stepanova, Maksim V. Dmitriev, Michael Rubin, and Andrey N. Maslivets. "Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea." Beilstein Journal of Organic Chemistry 15 (November 27, 2019): 2864–71. http://dx.doi.org/10.3762/bjoc.15.280.

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A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin–thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without applying preparative chromatography methods.

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3

Allegretti, Patricia E., M. de las Mercedes Schiavoni, Celia Guzmán, Agustín Ponzinibbio, and Jorge J. P. Furlong. "Mass Spectral Study of the Occurrence of Tautomeric Forms of Thiohydantoins." European Journal of Mass Spectrometry 13, no. 4 (2007): 291–306. http://dx.doi.org/10.1255/ejms.885.

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Mass spectrometry is used to evaluate the occurrence of thio-enol structures among the several possible tautomers of thiohydantoins and dithiohydantoins. Mass spectra of differently-substituted thiohydantoins are examined looking for common mass spectral behaviors to be predicted. Ion fragmentations from specific tautomers allow the most stable thio-enol structure for both type of compounds. The mass spectrum of the alkylation product of 5,5-dimethyldithiohydantoin and the nuclear magnetic resonance spectra of the alkylation products of both 2-thiohydantoin and dithiohydantoin support the fact

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4

Zhang, Ranran, Junhong Liu, Hui Yan, Xingrong Peng, Ling Zhang, and Minghua Qiu. "Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)." Molecules 26, no. 16 (2021): 4934. http://dx.doi.org/10.3390/molecules26164934.

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Five new thiohydantoin derivatives (1–5) were isolated from the rhizomes of Lepidium meyenii Walp. NMR (1H and 13C NMR, 1H−1H COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds. Significantly, the structure of compound 1 was the first example of thiohydantoins with thioxohexahydroimidazo [1,5-a] pyridine moiety. Additionally, compounds 2 and 3 possess rare disulfide bonds. Except for compound 4, all isolates were assessed for neuroprotective activities in corticosterone (CORT)-stimulated PC12 cell damage. Among them, compound (−)-3 exhibited mo

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5

A. Gotmare, Prashant, and Sanjay V. Kolhe. "Design of Novel Thiohydantoin Derivatives and Exploration their Physico-Chemical Parameters." Oriental Journal Of Chemistry 39, no. 5 (2023): 1264–71. http://dx.doi.org/10.13005/ojc/390520.

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Thiohydantoin analogues was heterocyclic non-aromatic five membered cyclic compounds obtained from aurones derivatives. In this article, we synthesized novel thiohydantoin derivatives and exploration of physicochemical parameters like density, viscosity, ultrasonic velocity, intermolecular free path, adiabatic compressibility etc. The structural elucidation of resultant compounds was done on the basis 1HNMR, IR, Mass etc. The present study revealed that, thiohydantoin analogues shows more structure making capacity in DMSO than DMF.

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6

Casagranda, F., BM Duggan, A. Kirkpatrick, RL Laslett, and JFK Wilshire. "Studies in Thiohydantoin Chemistry. II. C-Terminal Sequencing of Peptides." Australian Journal of Chemistry 49, no. 5 (1996): 551. http://dx.doi.org/10.1071/ch9960551.

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An investigation has been carried out into the thiocyanate degradation (AcOH/Ac2O/HSCN) procedure as it relates to the C-terminal sequencing of peptides, particular emphasis being placed on the sequencing of amino acid residues containing sensitive or functional side chains. Attempted C-terminal sequencing of several serine- and threonine -containing peptides stopped at these particular residues, and did not proceed further. It is concluded that sequencing of most of the common amino acids is achievable but that significant problems will have to be overcome before routine sequencing of proline

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7

Cejpek, K., and J. Velíšek. "Advances in Chemistry of Isothiocyanate-derived Colourants." Czech Journal of Food Sciences 27, Special Issue 1 (2009): S207—S210. http://dx.doi.org/10.17221/1092-cjfs.

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This study is focused on the reactions of isothiocyanates (ITCs) in the presence of amino compounds leading to coloured structures <I>via</I> substituted 2-thiohydantoins. A series of complementary experiments has been done and appropriate reaction conditions and structural prerequisites have been defined. Low-molecular colourants isolated and characterised from the model systems can be sorted into three groups. Yellow to red diastereomeric dehydrodimers of 2-thiohydantoin derivatives that contain an acidic methylene group are formed in mixtures consisted of ITCs and amino acids wi

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8

Stanic, Petar, Marko Rodic, Tanja Soldatovic та ін. "Reaction of a 3-aryilidene-2-thiohydantoin derivative with polymeric trans-[CuCl2(DMSO)2]n complex: Unexpected isomerization to dinuclear cis-[{CuCl(DMSO)2}(μ-Cl)]2". Journal of the Serbian Chemical Society, № 00 (2020): 60. http://dx.doi.org/10.2298/jsc200917060s.

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The 3-arylidene-2-thiohydantoin derivative, 3-[(2-hydroxybenzyl-idene)amino]-2-thioxoimidazolidin-4-one, was synthesized in a two-step condensation reaction of 2-hydroxybenzaldehyde, thiosemicarbazide and ethyl chloroacetate. The ligand was structurally characterized by NMR and IR spectroscopy, as well as elemental analysis. In the reaction of the well-known polymeric trans-[CuCl2(DMSO)2]n complex with the polydentate thiohydantoin type ligand, instead of the corresponding copper thiohydantoin complex, unexpectedly, the dinuclear cis-[{CuCl(DMSO)2}(m-Cl)]2 complex (1) was formed predominantly

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9

Jakše, Renata, David Bevk, Amalija Golobič, Jurij Svete та Branko Stanovnik. "Synthesis and Transformations of Ethyl 3-Formyl-1H-indole-2-carboxylate. Preparation of Aplysinopsin and β-Carboline Thiohydantoin Analogues". Zeitschrift für Naturforschung B 61, № 4 (2006): 413–19. http://dx.doi.org/10.1515/znb-2006-0407.

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Various aplysinopsin and β -carboline thiohydantoin analogues were prepared starting from ethyl 3-formyl-1H-indole-2-carboxylate by condensation with the active methylene group of 2-thiohydantoin, rhodanine, or thiobarbituric acid derivatives

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10

Stanić, Petar, Marija Živković, and Biljana Šmit. "Synthesis and Characterization of Various Amino Acid Derived Thiohydantoins." Proceedings 9, no. 1 (2018): 37. http://dx.doi.org/10.3390/ecsoc-22-05690.

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Hydantoins and their sulfur containing analogues, thiohydantoins, are cyclic ureides that have attracted huge attention ever since their discovery. Most of them are biologically active compounds and several points of structural diversity have made them very synthetically attractive. Although substituents can be introduced to the hydantoin nucleus, most substituted hydantoins are synthesized from substrates already containing these groups, while forming the hydantoin nucleus. This is a common route to the synthesis of hydantoins and one of them is employed in this study. A series of 3-allyl-2-t

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11

Prakash G, Mohan S, Sundararajan N, Senthil Kumar C, and Karpakavalli M. "Synthesis, Characterization and Anti-epileptic Activity of Thiohydantoin Derivatives." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 6490–94. http://dx.doi.org/10.26452/ijrps.v11i4.3524.

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A vast number of biological properties have been recognised to Thiohydantoin derivatives, have attracted continuing interest because of their various biological activities, namely anticonvulsant, hypolipidemic activity, anti-thyroidal activity, and anti-microbial actions. In this look upon, multiple numbers of Thiohydantoin derivatives are synthesised besides anti-epileptic mechanisms have been investigated. A series of 3-substituted 2-thiohydantoin Derivatives were synthesised from Benzil via Benzil-Benzilic Acid Rearrangement, characterised and evaluated for their anti-epileptic activity by

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12

Stanic, Petar, Darko Asanin, Tanja Soldatovic, and Marija Zivkovic. "Kinetic investigation of reactions of a 3-arylidene-2-thiohydantoin derivative with palladium (II) salts." Journal of the Serbian Chemical Society, no. 00 (2023): 52. http://dx.doi.org/10.2298/jsc230626052s.

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1H NMR spectroscopy was used to monitor the reactions of an arylidene 2-thiohydantoin derivative, 3-((phenylmethylene)amino)-2-thioxo-4- imidazolidinone (3), with PdCl2, cis-[PdCl2(dmso-S)2] and K2[PdCl4] in DMSO-d6 in order to elucidate the reaction kinetics and mechanism. The 2-thiohydantoin derivative 3 formed cis-[Pd(3-N,S)(dmso-S)2]+ complex (5) in reactions with PdCl2 and cis-[PdCl2(dmso-S)2], while no reaction with K2[PdCl4] was observed. A two-step mechanism for the reactions of 3 with PdCl2 and cis-[PdCl2(dmso- S)2] is proposed, in which fast coordination to the side chain nitrogen oc

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13

DELGADO, G. E., Asiloé J. MORA, T. GONZÁLEZ, I. SANTOS, P. RIVAS, and L. E. SEIJAS. "SOLVENT-FREE SYNTHESIS AND CRYSTAL STRUCTURE OF rac-2-THIOHYDANTOIN-VALINE." Periódico Tchê Química 16, no. 31 (2019): 347–52. http://dx.doi.org/10.52571/ptq.v16.n31.2019.353_periodico31_pgs_347_352.pdf.

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Thiohydantoins have been used in the manufacture of medicines and in industrial processes. Depending on the nature and type of substitution on the heterocyclic ring, these compounds may display pharmaceutical and biological activity with a variety of applications as antiepileptic, antitumoral, antiinflammatory, and principally for the treatment of prostate cancer. In this study, a new thiohydantoin was synthetized from the valine amino acid and structurally characterized. The title compound, C6H10N2O2S, with systematic name rac-5-isopropyl-2-tioxoimidazolidin-4-one, has been synthetized by a s

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14

D., C. Dash, Mahapatra A., P. Naik (Mrs.), K. Naik S., K. Mohapatra R., and S. Ghosh (Ms.). "Synthesis and characterization of UO22+, ZrO2+ and Th4+ complexes with 3-(p-substituted aryl)-2-thiohydantoin." Journal of Indian Chemical Society Vol. 85, June 2008 (2008): 595–99. https://doi.org/10.5281/zenodo.5816598.

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P.G. Department of Chemistry. Sambalpur University. Jyoti Vihar. Burla-768 019. Orissa, India <em>E-maiL :</em> dhruba _ dash@yahoo.co.in <em>Manuscript received 27 December 2007, revised 9 April 2008. accepted 15 April 2008</em> A few complexes of the type [ML<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>] and [ThL<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>(NO<sub>3</sub>) <sub>2</sub>]. where M = UO<sub>2</sub><sup>2+</sup>and ZrO<sup>2+</sup>; HL = 3- benzylideneimino-2-thiohydantoin, 3-p-nitrobenzylideneimino-2-thiohydantoin, 3-p-methoxybenzylideneimino-2-thiohydantoin, 3-p-chlorobenzylideneimino-2

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15

Sleeckx, Jef J. M., Marc J. O. Anteunis, and Frans A. M. Borremans. "Proton magnetic resonance study of the conformation of the pyrrolidine ring in some proline-thiohydantoins." Collection of Czechoslovak Chemical Communications 53, no. 11 (1988): 2503–10. http://dx.doi.org/10.1135/cccc19882503.

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The conformational behaviour of a series of N-substituted thiohydantoins of proline was studied by proton NMR. The pseudorotational parameters of the proline moiety were calculated from the ten vicinal proton-proton coupling constants assuming a two state equilibrium (N ⇋ S). The effect of the different substituents (methyl, phenyl, para-nitrophenyl) at the thiohydantoin nitrogen on the conformation of the pyrrolidine rings is discussed. The spectra of proline-N-methylthiohydantoin were recorded at different temperatures in octadeuterotoluene solution. The conformational analysis of these spec

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16

Duggan, BM, RL Laslett, and JFK Wilshire. "Studies in Thiohydantoin Chemistry. I. Some Aspects of the Schlack-Kumpf Reaction." Australian Journal of Chemistry 49, no. 5 (1996): 541. http://dx.doi.org/10.1071/ch9960541.

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An investigation has been carried out into the Schlack-Kumpf reaction, i.e., the reaction of amino acids with a mixture of acetic anhydride, acetic acid and sodium thiocyanate (occasionally ammonium thiocyanate was used). Particular emphasis was placed on the reactions with amino acids containing sensitive or functional side chains, i.e., serine, threonine , arginine , proline , lysine, histidine , cysteine , and aspartic and glutamic acids. The reaction of serine, and of certain of its O- and N-substituted derivatives, takes an unusual course to give an acetylated thiohydantoin derivative of

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17

Bartkowiak, Aleksandra, Bartosz Orwat, Maciej Zalas, Przemyslaw Ledwon, Ireneusz Kownacki, and Waldemar Tejchman. "2-Thiohydantoin Moiety as a Novel Acceptor/Anchoring Group of Photosensitizers for Dye-Sensitized Solar Cells." Materials 13, no. 9 (2020): 2065. http://dx.doi.org/10.3390/ma13092065.

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Very recently, we have reported the synthesis and evaluation of biological properties of new merocyanine dyes composed of triphenylamine moiety, π-aromatic spacer, and rhodanine/2-thiohydantoin-based moiety. Interestingly, 2-thiohydantoin has never been studied before as an electron-accepting/anchoring group for the dye-sensitized solar cells (DSSCs). In the presented study, we examined the applicability of 2-thiohydantoin, an analog of rhodanine, in DSSC technology. The research included theoretical calculations, electrochemical measurements, optical characterization, and tests of the solar c

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18

Nefzi, Adel, Marc A. Giulianotti, and Richard A. Houghten. "Solid-phase synthesis of branched thiohydantoin benzimidazolinethiones and branched thiohydantoin tetrahydroquinoxalinediones." Tetrahedron Letters 41, no. 14 (2000): 2283–87. http://dx.doi.org/10.1016/s0040-4039(00)00162-3.

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19

Kania, Agnieszka, Waldemar Tejchman, Anna M. Pawlak, et al. "Preliminary Studies of Antimicrobial Activity of New Synthesized Hybrids of 2-Thiohydantoin and 2-Quinolone Derivatives Activated with Blue Light." Molecules 27, no. 3 (2022): 1069. http://dx.doi.org/10.3390/molecules27031069.

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Thiohydantoin and quinolone derivatives have attracted researchers’ attention because of a broad spectrum of their medical applications. The aim of our research was to synthesize and analyze the antimicrobial properties of novel 2-thiohydantoin and 2-quinolone derivatives. For this purpose, two series of hybrid compounds were synthesized. Both series consisted of 2-thiohydantoin core and 2-quinolone derivative ring, however one of them was enriched with an acetic acid group at N3 atom in 2-thiohydantoin core. Antibacterial properties of these compounds were examined against bacteria: Staphyloc

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20

Casas, J. S., A. Castiñeiras, D. Couce, N. Playá, J. Sordo, and J. M. Varela. "1-Acetyl-2-thiohydantoin." Acta Crystallographica Section C Crystal Structure Communications 54, no. 3 (1998): 427–28. http://dx.doi.org/10.1107/s0108270197014960.

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21

Roszak, A. W., and D. F. Weaver. "5,5-Diphenyl-2-thiohydantoin." Acta Crystallographica Section C Crystal Structure Communications 54, no. 8 (1998): 1168–70. http://dx.doi.org/10.1107/s0108270197019963.

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22

Aslanidis, P., S. Kyritsis, M. Lalia-Kantouri, B. Wicher, and M. Gdaniec. "Copper(I) halide complexes of 2-thiohydantoin and 5,5-diphenyl-2-thiohydantoin." Polyhedron 48, no. 1 (2012): 140–45. http://dx.doi.org/10.1016/j.poly.2012.08.065.

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23

Shybanov, Dmitry E., Maxim E. Kukushkin, Yanislav S. Hrytseniuk, et al. "[4+2]-Cycloaddition to 5-Methylidene-Hydantoins and 5-Methylidene-2-Thiohydantoins in the Synthesis of Spiro-2-Chalcogenimidazolones." International Journal of Molecular Sciences 24, no. 5 (2023): 5037. http://dx.doi.org/10.3390/ijms24055037.

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Novel hydantion and thiohydantoin-based spiro-compounds were prepared via theDiels–Alder reactions between 5-methylidene-hydantoins or 5-methylidene-2-thiohydantoins and 1,3-dienes (cyclopentadiene, cyclohexadiene, 2,3-dimethylbutadiene, isoprene). It was shown that the cycloaddition reactions proceed regioselectively and stereoselectively with the formation of exo-isomers in the reactions with cyclic dienes andthe less sterically hindered products in the reactions with isoprene. Reactions of methylideneimidazolones with cyclopentadiene proceed viaco-heating the reactants; reactions with cyclo

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24

Virijevic, Katarina, Petar Stanic, Jovana Muskinja, et al. "Synthesis and biological activity of novel zingerone-thiohydantoin hybrids." Journal of the Serbian Chemical Society, no. 00 (2022): 47. http://dx.doi.org/10.2298/jsc220404047v.

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A series of zingerone-thiohydantoin hybrids were synthesized from O-alkyl zingerone derivatives by cyclocondensation with thiosemicarbazide in a two-step reaction. Obtained new potentially bioactive compounds were structurally characterized by IR and NMR spectroscopy, as well as elemental and HRMS analysis. In addition, their antimicrobial and in vitro anticancer activities were tested. Tested compounds showed low to moderate antimicrobial activity. Zingerone-thiohydantoin hybrid with an O-buthyl substituent exerted the significant cytotoxic activity on colon HCT-116 cancer cells without toxic

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25

Marinov, Marin. "SYNTHESIS OF AMINO DERIVATIVES OF MONOTHIO- AND DITHIO- ANALOGUES OF CYCLOHEXANESPIRO-5-HYDANTOIN." Journal scientific and applied research 2, no. 1 (2012): 66–73. http://dx.doi.org/10.46687/jsar.v2i1.45.

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This article presents methods for synthesis of 3-amino derivatives of cyclohexanespiro-5-(2-thiohydantoin) and cyclohexanespiro-5-(2,4-dithiohydantoin). It was found out that the treatment of cyclohexanespiro-5-(2-thiohydantoin) with hydrazine hydrate under different reaction conditions led to obtaining of 3-amino derivative and 2-hydrazone of the initial compound. As a result of thionation of 3-aminocyclohexanespiro-5-hydantoin with P4S10 or Lawesson’s reagent, the corresponding dithio-analogue was synthesized. The structures of the products obtained were verified by IR, 1H NMR, 13C NMR and m

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26

D., C. Dash, P. Naik (Mrs.), K. Naik S., K. Mohapatra R., and S. Ghosh (Ms.). "Synthesis and characterization of UO2 VI ZrOIV and ThIV complexes with 3-(pyridyl/thienyl-2'-methylene/furfurylidene)imino-2-thiohydantoin." Journal of Indian Chemical Society Vol. 86, Sep 2009 (2009): 969–72. https://doi.org/10.5281/zenodo.5819646.

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P.G. Department of Chemistry, Sambalpur University. Jyoti Vihar, Burla. Sambalpur-768 019, Orissa. India <em>E-mail </em>: dhruba_dash@yahoo.co.in <em>Manuscript received 15 October 2008, revised 27 April 2009, accepted 18 May 2009</em> A few complexes of the type [ML<sub>2</sub>].<em>n</em>H<sub>2</sub>O and [ThL<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>]<sub>2</sub>H<sub>2</sub>O where HL = 3-pyridyl-2<em>'</em>-methyleneimino2-thiohydantoin (Hpmit), 3-thienyl-2<em>'</em>-methyleneimino-2-thiohydantoin (Htmit) and 3-furfurylideneimino-2-thiohydantoin (Hfit), M = UO<sub>2</sub

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27

Bathula, Chandramohan, Shreemoyee Ghosh, Santanu Hati та ін. "Bioisosteric modification of known fucosidase inhibitors to discover a novel inhibitor of α-l-fucosidase". RSC Advances 7, № 6 (2017): 3563–72. http://dx.doi.org/10.1039/c6ra24939f.

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Tejchman, Waldemar, Bartosz Orwat, Izabela Korona-Głowniak, et al. "Highly efficient microwave synthesis of rhodanine and 2-thiohydantoin derivatives and determination of relationships between their chemical structures and antibacterial activity." RSC Advances 9, no. 67 (2019): 39367–80. http://dx.doi.org/10.1039/c9ra08690k.

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29

Villemin, D., and M. Ricard. "Condensation on Alumina. III. Synthesis of 5-Alkylidene, 2-Thiohydantoin from 3-Acetyl, 2-Thiohydantoin." Synthetic Communications 17, no. 3 (1987): 283–89. http://dx.doi.org/10.1080/00397918708077308.

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30

Ismail, Lamia A., R. Zakaria, Eman M. Hassan, et al. "Novel imidazolium-thiohydantoin hybrids and their Mn(iii) complexes for antimicrobial and anti-liver cancer applications." RSC Advances 12, no. 44 (2022): 28364–75. http://dx.doi.org/10.1039/d2ra05233d.

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31

Elhady, Heba A., and Hossa F. Al-Shareef. "Synthesis, Characterization, Anti-proliferative Evaluation, and DNA Flow Cytometry Analysis of Some 2-Thiohydantoin Derivatives." Mini-Reviews in Medicinal Chemistry 20, no. 18 (2020): 1929–41. http://dx.doi.org/10.2174/1389557520666200611093510.

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Background and Objective: Due to the well-documented anti-proliferative activity of 2-thiohydantoin incorporated with pyrazole, oxadiazole, quinazoline, urea, β-naphthyl carbamate and Schiff bases, they are noteworthy in pharmaceutical chemistry. Methods: An efficient approach for the synthesis of a novel series of 2-thiohydantoin derivatives incorporated with pyrazole and oxadiazole has proceeded via the reaction of the acyl hydrazide with chalcones and/or triethyl orthoformate. Schiff bases were synthesized by the reaction of the acyl hydrazide with different aromatic aldehydes. Moreover, Cu

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32

Gawas, Pratiksha P., Buthanapalli Ramakrishna, N. Veeraiah, and Venkatramaiah Nutalapati. "Multifunctional hydantoins: recent advances in optoelectronics and medicinal drugs from Academia to the chemical industry." Journal of Materials Chemistry C 9, no. 46 (2021): 16341–77. http://dx.doi.org/10.1039/d1tc04090a.

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This review provides a detailed survey on the structural modifications of hydantoin (TH)/2-thiohydantoin (2TH) derivatives and understanding of their photophysical properties, enabling their potential use in optoelectronics and prototypes.

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33

Chepik, Aleksey, and Alena Istomina. "TESTING NICKEL PLATING ELECTROLYTE WITH ADDITIVE 2-THIOHYDANTOIN IN THE CORNER HULLA CELL." Modern Technologies and Scientific and Technological Progress 2024, no. 1 (2024): 77–78. http://dx.doi.org/10.36629/2686-9896-2024-1-77-78.

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A nickel sulfate electrolyte with the addition of 2-thiohydantoin was tested in a corner Hull cell. The range of operating current densities and additive concentrations for obtaining shiny nickel coatings have been determined

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34

OGAWA, Toshiakzu, Hisako OKUMURA, Mitsunori HONDA, et al. "A New Polymorph of 2-Thiohydantoin." X-ray Structure Analysis Online 25 (2009): 91–92. http://dx.doi.org/10.2116/xraystruct.25.91.

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35

Mackay, M. F., B. M. Duggan, R. L. Laslett, and J. F. K. Wilshire. "Structure of a substituted 2-thiohydantoin." Acta Crystallographica Section C Crystal Structure Communications 48, no. 2 (1992): 334–36. http://dx.doi.org/10.1107/s0108270191009575.

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36

Lin, Mei-Jung, and Chung-Ming Sun. "Microwave-assisted traceless synthesis of thiohydantoin." Tetrahedron Letters 44, no. 48 (2003): 8739–42. http://dx.doi.org/10.1016/j.tetlet.2003.09.156.

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37

Kaválek, Jaromír, Vladimír Macháček, Gabriela Svobodová, and Vojeslav Štěrba. "Base catalyzed cyclization of substituted esters of hydantoic and thiohydantoic acids." Collection of Czechoslovak Chemical Communications 51, no. 2 (1986): 375–90. http://dx.doi.org/10.1135/cccc19860375.

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Base catalyzed cyclization rates have been measured of 22 derivatives of hydantoic and thiohydantoic acid esters in water and methanol. The cyclization of methyl and ethyl esters of hydantoic and 5-methylhydantoic acids is accompanied by hydrolysis of the ester group, whereas with the other derivatives the hydrolysis does not take place. Hydrolysis of the cyclization products (hydantoin and thiohydantoin derivatives) is not significant under the kinetic conditions. The cyclization of methyl ester of 5-phenylhydantoic acid in methanol is reversible; the equilibrium mixture contains 30% of the s

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38

Abadi, Ashraf H., Jochen Lehmann, Gary A. Piazza, Mohammad Abdel-Halim та Mohamed S. M. Ali. "Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors". International Journal of Medicinal Chemistry 2011 (23 лютого 2011): 1–9. http://dx.doi.org/10.1155/2011/562421.

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Two series of fused tetrahydro-β-carboline hydantoin and tetrahydro-β-carboline thiohydantoin derivatives with a pendant 2,4-dimethoxyphenyl at position 5 were synthesized, and chiral carbons at positions 5 and 11a swing from R,R to R,S, S,R, and S,S. The prepared analogues were evaluated for their capacity to inhibit phosphodiesterase 5 (PDE5) isozyme. The R absolute configuration of C-5 in the β-carboline hydantoin derivatives was found to be essential for the PDE5 inhibition. Chiral carbon derived from amino acid even if of the S configuration (L-tryptophan) may lead to equiactive or more a

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39

POYRAZ, Samet, H. Ali DÖNDAŞ, Samet BELVEREN, and Hayati SARI. "Acid ionization constant of potential bioactive functionalized N benzoylthiourea/ 2-thiohydantoin-pyrrolidine derivatives by potentiometric titration in acetonitrile-water." Revue Roumaine de Chimie 69, no. 5-6 (2024): 321–29. http://dx.doi.org/10.33224/rrch.2024.69.5-6.10.

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The acid ionization constants (pKa) of the N-benzoylthiourea / 2-thiohydantoin-pyrrolidines were determined by the potentiometric titration method. Titrations were performed by adding sodium chloride, which gives ionic strength, and hydrochloric acid, which is required for the protonation of the ionizable groups, to 2x10-4 M solutions of the synthesized compounds prepared in an acetonitrile-water (20:80, v / v) solvent system at 25 ± 0.1 °C and sodium hydroxide was used as a titrant. The HYPERQUAD computer program was utilized to determine acid ionization constants based on the data obtained f

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40

Fedorchuk, Andrii, Evgeny Goreshnik, Yurii Slyvka та Marian Mys’kiv. "Cu(I) Arylsulfonate π-Complexes with 3-Allyl-2-thiohydantoin: The Role of the Weak Interactions in Structural Organization". Acta Chimica Slovenica 67, № 4 (2020): 1148–54. http://dx.doi.org/10.17344/acsi.2020.6045.

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The present work is directed toward preparation and structural characterization of two novel Cu(I) arylsulfonate π-complexes with 3-allyl-2-thiohydantoin, namely [Cu2(Hath)4](C6H5SO3)2 (1) and [Cu2(Hath)4](p-CH3C6H4SO3)2 · 2H2O (2) (Hath = 3-allyl-2-thiohydantoin), obtained by the means of alternating current electrochemical synthesis and studied with X-ray diffraction method. In both structures, the inner coordination sphere is represented by the cationic dimer [Cu2(Hath)4]2+ with one crystallographically independent copper(I) atom which has a trigonal pyramidal coordination environment forme

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41

Smokal, Vitaliy, Oksana Krupka, Aleksey Kolendo, Beata Derkowska, Robert Czaplicki, and Bouchta Sahraoui. "Synthesis, polymerization ability, nonlinear optical properties of methacrylic monomers and polymers with benzylidene moiety." Chemistry & Chemical Technology 1, no. 3 (2007): 131–35. http://dx.doi.org/10.23939/chcht01.03.131.

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New methacrylic monomers, their polymers with benzylidene fragment were synthesized. Structures of all compounds were determined by HNMR, UV- spectroscopies. The third order nonlinear optical properties of oxazolone, thiazolidinone and thiohydantoin containing compounds were investigated in solutions using degenerate four wave mixing (DFWM) method at 532 nm.

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42

Liu, Ruiyuan, Xue Yong, Xiaodong Yang, Yichen Yan, Xinwei Lu, and Jinqing Qu. "Fluoride Ion Probe Based on 2-Thiohydantoin." Chinese Journal of Organic Chemistry 34, no. 3 (2014): 561. http://dx.doi.org/10.6023/cjoc201310023.

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43

Uemura, Naohiro, Yasushi Yoshida, Takashi Mino, and Masami Sakamoto. "Crystallization-induced diastereomer transformation of thiohydantoin derivatives." Tetrahedron 76, no. 20 (2020): 131166. http://dx.doi.org/10.1016/j.tet.2020.131166.

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44

Sarigul, Sevgi, and Ilknur Dogan. "Atroposelective Synthesis of Axially Chiral Thiohydantoin Derivatives." Journal of Organic Chemistry 81, no. 14 (2016): 5895–902. http://dx.doi.org/10.1021/acs.joc.6b00696.

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45

Mahfouz, Refaat M., Anwar S. El Shahawy, and Ali A. Hassan. "A new technetium(V)-2-thiohydantoin complex." Transition Metal Chemistry 19, no. 4 (1994): 385–86. http://dx.doi.org/10.1007/bf00139309.

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46

Jakšea, Renata, Vesna Krošelj, Simon Rečnik, et al. "Stereoselective Synthesis of 5-[(Z)-Heteroarylmethylidene] Substituted Hydantoins and Thiohydantoins as Aplysinopsin Analogs." Zeitschrift für Naturforschung B 57, no. 4 (2002): 453–59. http://dx.doi.org/10.1515/znb-2002-0411.

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3-Substituted 5-[(Z)-heteroarylmethylidene]imidazolidine-2,4-dione and 5-[(Z)-heteroarylmethylidene]- 2-thiooxoimidazolidin-4-one derivatives were prepared stereoselectively by coupling of 5-(dimethylamino)methylidene substituted hydantoin and thiohydantoin derivatives with carbocyclic and heterocyclic C-nucleophiles.Configuration around the exocyclic C=C double bond was determined by NMR, using NOESY and 2D HMBC techniques.

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47

Waldron, Karen C., Shaole Wu, Colin W. Earle, Heather R. Harke, and Norman J. Dovichi. "Capillary zone electrophoresis separation and laser-based detection of both fluorescein thiohydantoin and dimethylaminoazobenzene thiohydantoin derivatives of amino acids." Electrophoresis 11, no. 9 (1990): 777–80. http://dx.doi.org/10.1002/elps.1150110918.

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48

Veverka, Miroslav, and Miroslav Marchalín. "Addition-cyclization reactions of ethyl isothiocyanatoacetate with carboxylic acid hydrazides." Collection of Czechoslovak Chemical Communications 52, no. 1 (1987): 113–19. http://dx.doi.org/10.1135/cccc19870113.

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Ethyl (3-substituted 5-thioxo-1,2,4-triazolin-4-yl)acetates were prepared by addition-cyclization reaction of ethyl isothiocyanatoacetate with carboxylic acid hydrazides in the presence of sodium ethoxide. Thermal cyclization of the adduct in dimethylformamide afforded 1-acetamido-2-thiohydantoin. The effect of substituents on the cyclization course and the thione-thiol tautomerism are discussed.

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49

Guk, Dmitry, Alexei Naumov, Olga Krasnovskaya, et al. "Three types of copper derivatives formed by CuCl2·2H2O interaction with (Z)-3-aryl-2-(methylthio)-5-(pyridine-2-ylmethylene)-3,5-dihydro-4H-imidazol-4-ones." Dalton Transactions 49, no. 41 (2020): 14528–35. http://dx.doi.org/10.1039/d0dt02817g.

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CuCl<sub>2</sub>·2H<sub>2</sub>O reacts with 5-(pyridine-2-ylmethylene)-thiohydantoin derivatives (L) in reducing solvent-forming compounds with a composition of Cu<sup>II</sup>(L)Cl<sub>2</sub>, Cu<sup>I</sup>(L)Cl, and (L + H)<sup>+</sup>Cu<sup>I</sup>Cl<sub>2</sub><sup>−</sup>.

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50

Mukerjee, Arya K., Laxmi Rao, Seyed Saied Homami, and Kiran Joseph. "Reaction of unsaturated azlactones with sulfur nucleophiles: some observations." Canadian Journal of Chemistry 72, no. 5 (1994): 1383–87. http://dx.doi.org/10.1139/v94-173.

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Unsaturated azlactones undergo thiolysis with toluene-α-thiol, but 2-substituted (Z)-4-o-acetoxybenzylidene-4,5-dihydrooxazol-5-ones form 3-acylaminocoumarins in the presence of triethylamine. Sodium sulfide in ethanol brings about ethanolysis of the 1,5 bond and deacetylation of an acetoxy group. (Z)-4-Benzylidene-4,5-dihydrooxazol-5-one reacts with potassium thiocyanate to give (E)-4(5)-benzylidene-2-thiohydantoin.

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