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Journal articles on the topic 'Thiophen Derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Vu Quoc, Trung, Duong Tran Thi Thuy, Thuan Dang Thanh, et al. "Some chalcones derived from thiophene-3-carbaldehyde: synthesis and crystal structures." Acta Crystallographica Section E Crystallographic Communications 75, no. 7 (2019): 957–63. http://dx.doi.org/10.1107/s2056989019007503.

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The synthesis, spectroscopic data and crystal and molecular structures of four 3-(3-phenylprop-1-ene-3-one-1-yl)thiophene derivatives, namely 1-(4-hydroxyphenyl)-3-(thiophen-3-yl)prop-1-en-3-one, C13H10O2S, (1), 1-(4-methoxyphenyl)-3-(thiophen-3-yl)prop-1-en-3-one, C14H12O2S, (2), 1-(4-ethoxyphenyl)-3-(thiophen-3-yl)prop-1-en-3-one, C15H14O2S, (3), and 1-(4-bromophenyl)-3-(thiophen-3-yl)prop-1-en-3-one, C13H9BrOS, (4), are described. The four chalcones have been synthesized by reaction of thiophene-3-carbaldehyde with an acetophenone derivative in an absolute ethanol solution containing potass

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2

Clark, Peter D., Nicholas M. Irvine, and Pratibha Sarkar. "The synthesis of 3H-naphthol[1,8-bc]thiophene derivatives." Canadian Journal of Chemistry 69, no. 6 (1991): 1011–16. http://dx.doi.org/10.1139/v91-148.

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Methods for the synthesis of keto derivatives of the little studied naphtho[1,8-bc]thiophene system have been developed. Using the readily available benzothiophene derivative 6,7-dihydrobenzo[b]thiophen-4(5H)-one 4, a 3-keto-naphtho[1,8-bc]thiophene 14 was synthesized by a tin(IV) chloride catalyzed cyclization of the acid chloride derivative of the saturated acid 13b. The bicyclic ketone 4 was also used to prepare the keto-sulfoxide 7, which was cyclized to the 4-keto-naphtho[1,8-bc]thiophene system 9 in a Pummerer-type rearrangement. Key words: synthesis, organosulfur, naphtho[1,8-bc]thiophe

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3

Arrousse, N., Y. Fernine, Nabil Al-Zaqri, et al. "Thiophene derivatives as corrosion inhibitors for 2024-T3 aluminum alloy in hydrochloric acid medium." RSC Advances 12, no. 17 (2022): 10321–35. http://dx.doi.org/10.1039/d2ra00185c.

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Thiophene derivatives: thiophene-2-carbaldehyde oxime (OXM) and 5-(thiophen-2-yl)-1H-tetrazole (TET), were synthesized and characterized. Furthermore, their inhibitory property for AA2024-T3 in 1 M HCl solution was investigated via electrochemical and with theoretical study.

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4

Salbeck, Josef, and Erhard Günther. "Elektrochemische und spektroelektrochemische Untersuchungen neuer S-heterochinoider Elektronenakzeptoren, N-Cyanimin-substituierte Thieno[3,2-b]thiophen-2,5-dione / Electrochemical and Spectroelectrochemical Investigations of New S-Heteroquinoid Electron Acceptors, N-Cyanimine Substituted Thieno[3,2-b]thiophene-2,5-diones." Zeitschrift für Naturforschung B 46, no. 3 (1991): 353–60. http://dx.doi.org/10.1515/znb-1991-0315.

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5

Wang, Qing Xiu, Li Jie Duan, Bo Yang Qu, Juan Wang, and Fu De Liu. "Synthesis and Optical/Electrochemical Properties of Conjugated Polymers with Diphenyl and Thiophene in Main Chain." Advanced Materials Research 1035 (October 2014): 497–501. http://dx.doi.org/10.4028/www.scientific.net/amr.1035.497.

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Two thiophene derivatives 4,4'-di (thiophen-2-yl) biphenyl and 4,4'-di (thiophen-2-yl) -2-nitrobiphenyl ,which were used as monomers for preparing poly (4,4'-di (thiophen-2-yl) biphenyl) (DPBT) and poly (4,4'-di (thiophen-2-yl)-2-nitrobiphenyl) (DPNT) by ferric chloride oxidation polymerization, were synthesized via Suzuki reaction with 4,4'-dibromobiphenyl as the raw material. UV-vis absorption spectra, fluorescence spectra, photoluminescence spectra and electrochemical properties of the polymers were recorded and used for calculating the band-gap (Eg), HOMO orbital energy (EHOMO) and LUMO or

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6

Lahsasni, Siham, Dunya A. M. Al-Hemyari, Hazem A. Ghabbour, et al. "Synthesis, Characterization, and Antibacterial and Anti-Inflammatory Activities of New Pyrimidine and Thiophene Derivatives." Journal of Chemistry 2018 (August 1, 2018): 1–11. http://dx.doi.org/10.1155/2018/8536063.

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Substituted[4,5]thieno[2,3-d]thiazolo[3,2-a]pyrimidin-5-one (3a–b) and pyrimidin-5(6H)-imine (3c–e) were synthesized via reaction of the starting compounds, ethyl 2-amino-substituted[b]thiophene-3-carboxylate (2a–c) and 2-amino-substituted [b]thiophene-3-carbonitrile (2d–f), respectively, with 2-bromothiazole. Synthesis of (bromo-substituted[b]thiophen-2-yl)alkanamide derivatives (4a–e) and thieno[2,3-d][1,3]oxazin-4-imine derivative (5) was accomplished via reaction of the starting compounds with bromoalkyl chloride through nucleophilic substitution; however, for the synthesis of compound 5,

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7

Cherniawski, Benjamin P., Steven A. Lopez, Edmund K. Burnett, et al. "The effect of hexyl side chains on molecular conformations, crystal packing, and charge transport of oligothiophenes." Journal of Materials Chemistry C 5, no. 3 (2017): 582–88. http://dx.doi.org/10.1039/c6tc04612f.

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8

Wojciechowski, Krzysztof, and Michał Nowacki. "Synthesis of [1]Benzothieno[2,3-b]quinolines via Transition-Metal-Free [3+3] Annulation of Nitroarenes and Benzo[b]thiophen-3-ylacetonitrile or 3-(Phenylsulfonylmethyl)benzo[b]thiophene Carbanions." Synthesis 49, no. 16 (2017): 3794–800. http://dx.doi.org/10.1055/s-0036-1588426.

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Benzo[b]thiophen-3-ylacetonitriles or 3-(phenylsulfonylmethyl)benzo[b]thiophenes react with nitrobenzene derivatives in the presence of potassium tert-butoxide and chlorotrimethylsilane to form, in good yields, 11-cyano- or 11-(phenylsulfonyl)[1]benzothieno[2,3-b]quinolines, respectively.

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9

Ryu, Seunghyup, Chaeyoung Yun, Soomin Ryu, Jihae Ahn, Choongik Kim, and Sungyong Seo. "Characterization of [1]Benzothieno[3,2-b]benzothiophene (BTBT) Derivatives with End-Capping Groups as Solution-Processable Organic Semiconductors for Organic Field-Effect Transistors." Coatings 13, no. 1 (2023): 181. http://dx.doi.org/10.3390/coatings13010181.

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Solution-processable [1]benzothieno[3,2-b]benzothiophene (BTBT) derivatives with various end-capping groups, 2-(phenylethynyl)benzo[b]benzo[4,5]thieno[2,3-d]thiophene (Compound 1), 2-octyl-7-(5-(phenylethynyl)thiophen-2-yl)benzo[b]benzo[4,5]thieno[2,3-d]thiophene (Compound 2), and triisopropyl((5-(7-octylbenzo[b]benzo[4,5]thieno[2,3-d]thiophen-2-yl)thiophen-2-yl)ethynyl)silane (Compound 3), have been synthesized and characterized as active layers for organic field-effect transistors (OFETs). Thermal, optical, and electrochemical properties of the newly synthesized compounds were characterized

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10

Al-Refai, Mahmoud, Basem F. Ali, Ala'a B. Said, Armin Geyer, Michael Marsch, and Klaus Harms. "Synthesis, characterization, crystal structure and supramolecularity of ethyl (E)-2-cyano-3-(3-methylthiophen-2-yl)acrylate and a new polymorph of ethyl (E)-2-cyano-3-(thiophen-2-yl)acrylate." Acta Crystallographica Section E Crystallographic Communications 75, no. 9 (2019): 1357–61. http://dx.doi.org/10.1107/s2056989019011435.

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The synthesis, crystal structure and structural motif of two thiophene-based cyanoacrylate derivatives, namely, ethyl (E)-2-cyano-3-(3-methylthiophen-2-yl)acrylate (1), C11H11NO2S, and ethyl (E)-2-cyano-3-(thiophen-2-yl)acrylate (2), C10H9NO2S, are reported. Derivative 1 crystallized with two independent molecules in the asymmetric unit, and derivative 2 represents a new monoclinic (C2/m) polymorph. The molecular conformations of 1 and the two polymorphs of 2 are very similar, as all non-H atoms are planar except for the methyl of the ethyl groups. The intermolecular interactions and crystal p

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11

Hajib, Sara, Mohamed Hssaini, Anouar Alami, et al. "Evaluation of the Antibacterial Activity of 5-(thiophen-2-yl)-1H-tetrazole and Its Oxime Derivative against ATCC Reference Strains and Strains Isolated from the Hospital Environment of a Provincial Public Hospital in the City of Fez." European Journal of Advanced Chemistry Research 2, no. 2 (2021): 16–24. http://dx.doi.org/10.24018/ejchem.2021.2.2.54.

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Bacterial resistance to antibiotics and disinfectants has become a real concern. The hospital presents a favorable environment for the colonization and development of bacteria resistant to antibiotics and disinfectants. The search for new antimicrobial compounds is essential to combat this phenomenon. Tetrazole derivatives may represent a solution due to their interesting antibacterial activity. In this work, two tetrazole derivatives; thiophene-2-carbaldehyde (T2C) and 5-(thiophen-2-yl)-1H-tetrazole (5TPh-1HT), were evaluated for their antibacterial activities against a set of reference strai

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12

Safonov, A. A. "Study acute toxicity of 4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol in vivo." Farmatsevtychnyi zhurnal, no. 2 (August 14, 2018): 98–101. http://dx.doi.org/10.32352/0367-3057.2.16.06.

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Typically, the system is already known are used as the core for a new substance, which have already proved themselves as potential drugs. So one of these is 1,2,4-triazole ring. The purpose was to study acute toxicity of 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiols and identify possible patterns acute toxicity of the chemical structure of indicators derivatives. In the study of acute contact toxicity was used spreadsheet rapid method for Prozorovsky V. B. Analysis of the results of studies acute toxicity of 1,2,4-triazole derivatives showed that all substanc

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13

Abdel-Rahman, Adel A. H., Amira K. F. Shaban, Ibrahim F. Nassar, et al. "Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity." Molecules 26, no. 13 (2021): 3923. http://dx.doi.org/10.3390/molecules26133923.

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New pyridine, pyrazoloyridine, and furopyridine derivatives substituted with naphthyl and thienyl moieties were designed and synthesized starting from 6-(naphthalen-2-yl)-2-oxo-4-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile (1). The chloro, methoxy, cholroacetoxy, imidazolyl, azide, and arylamino derivatives were prepared to obtain the pyridine-‑C2 functionalized derivatives. The derived pyrazolpyridine-N-glycosides were synthesized via heterocyclization of the C2-thioxopyridine derivative followed by glycosylation using glucose and galactose. The furopyridine derivative 14 and the tricy

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14

Hien, Nguyen, and Duong Quoc Hoan. "Synthesis of some mono and dialkynyl derivatives containing thieno[3,2-b]thiophene ring via Sonogashira alkynylation reaction." Tạp chí Khoa học 14, no. 9 (2019): 85. http://dx.doi.org/10.54607/hcmue.js.14.9.2206(2017).

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The Sonogashira cross-coupling reactions were used to synthesize 5 new monoalkynyl derivatives (10a-e) and 2 dialkynyl derivatives (12a-b) containing thieno[3,2-b]thiophene from monoaryl thieno[3,2-b]thiophen in moderate yield. The procedure was optimized and triphenylphosphine (0.2 eq.), palladium diacetate (0.1 eq), copper (I) iodide (0.2 eq.), THF, iPr2NH were found to be the best in these cases. The structures of the (10a-e) and (12a-b) compounds were elucidated by 1H and 13C NMR and mass spectral analysis.

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15

Kathrotiya, Haresh G., Sagar P. Gami, and Yogesh T. Naliapara. "An Efficient and Clean Synthesis of Thiophenyl Thiazole Depended Novel Triazolo[4,3-a]Quinoxaline Derivatives." International Letters of Chemistry, Physics and Astronomy 51 (May 2015): 125–34. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.51.125.

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A simple and efficient approach for the synthesis of thiophenyl thiazole based triazolo [4,3-a] quinoxaline derivatives is described. In this methodology, 3-hydrazinyl-N-(4-(thiophen-2-yl) thiazol-2-yl) quinoxalin-2-amine derivatives treated with various aromatic aldehyde to form Schiff base which on treatment with iodobenzene diacetate in dichloromethane at room temperature to furnish title compounds. The synthesized compounds were characterized by 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectral data

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16

Kathrotiya, Haresh G., Sagar P. Gami, and Yogesh T. Naliapara. "An Efficient and Clean Synthesis of Thiophenyl Thiazole Depended Novel Triazolo[4,3-<i>a</i>]Quinoxaline Derivatives." International Letters of Chemistry, Physics and Astronomy 51 (May 15, 2015): 125–34. http://dx.doi.org/10.56431/p-flw9zc.

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A simple and efficient approach for the synthesis of thiophenyl thiazole based triazolo [4,3-a] quinoxaline derivatives is described. In this methodology, 3-hydrazinyl-N-(4-(thiophen-2-yl) thiazol-2-yl) quinoxalin-2-amine derivatives treated with various aromatic aldehyde to form Schiff base which on treatment with iodobenzene diacetate in dichloromethane at room temperature to furnish title compounds. The synthesized compounds were characterized by 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectral data

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17

Vrábel, Viktor, Július Sivý, Peter Šafář, and Štefan Marchalín. "Electronic structure, novel synthesis, and O—H...O and C—H...O interactions in two 6-oxopiperidine-2-carboxylic acid derivatives." Acta Crystallographica Section C Structural Chemistry 70, no. 8 (2014): 817–22. http://dx.doi.org/10.1107/s2053229614016301.

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Molecules of (S)-6-oxo-1-(thiophen-2-ylmethyl)piperidine-2-carboxylic acid, C11H13NO3S, crystallize as single enantiomers in the space groupP21and the thiophene ring is disordered over two positions, while (S)-6-oxo-1-(thiophen-3-ylmethyl)piperidine-2-carboxylic acid, C11H13NO3S, crystallizes as a single enantiomer in the space groupP212121. Their absolute configurations were confirmed by anomalous dispersion effects in diffraction measurements on the crystals. The molecules of each compound are linked by a combination of strong O—H...O hydrogen bonds and weak C—H...O interactions, resulting i

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18

Lei, Xiao Long, Xiao Xia Sun, Pei Lin Zhang, and Yu Hu. "The New Synthesis of Quinoxaline Derivatives Monomer." Advanced Materials Research 781-784 (September 2013): 567–70. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.567.

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The monomer of 2,3-di (thiophen-2-yl) quinoxaline (M1) and 2,3-di (thiophen-2-yl) 1,4-pyradiazine (M2) have been synthesized in moderate yields over two steps from readily available starting materials. The π-conjugated Polymer based on 2,3-di (thiophen-2-yl) quinoxaline was synthesized by Electrochemical workstation which was carried out in DCM/ Bu4NBF4 (0.1M) as the solvent/electrolyte couple. The new π-conjugated Polymer can slightly soluble in organic solvents such as methylene chloride and acetonitrile.

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19

Demina, Nadezhda S., Nikita A. Kazin, Nikolay A. Rasputin, Roman A. Irgashev, and Gennady L. Rusinov. "Synthesis of aryl-substituted thieno[3,2-b]thiophene derivatives and their use for N,S-heterotetracene construction." Beilstein Journal of Organic Chemistry 15 (November 12, 2019): 2678–83. http://dx.doi.org/10.3762/bjoc.15.261.

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Fiesselmann thiophene synthesis was applied for the convenient construction of thieno[3,2-b]thiophene derivatives. Thus, new 5- or 6-aryl-3-hydroxythieno[3,2-b]thiophene-2-carboxylates were obtained by condensation of 5- or 4-aryl-3-chlorothiophene-2-carboxylates, respectively, with methyl thioglycolate in the presence of potassium tert-butoxide. The saponification of the resulting esters, with decarboxylation of the intermediating acids, gave the corresponding thieno[3,2-b]thiophen-3(2H)-ones. The latter ketones were used to synthesize new N,S-heterotetracenes, namely 9H-thieno[2',3':4,5]thie

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20

Choi, Eunjin, Yuhyeon Jang, Dongil Ho, et al. "Development of Dithieno[3,2-b:2′,3′-d]thiophene (DTT) Derivatives as Solution-Processable Small Molecular Semiconductors for Organic Thin Film Transistors." Coatings 11, no. 10 (2021): 1222. http://dx.doi.org/10.3390/coatings11101222.

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Novel solution-processable dithieno[3,2-d:2′,3′-d]thiophene (DTT) derivatives with alkylated thiophene or alkyl chain substituents, 2,6-bis(5-octylthiophen-2-yl)dithieno[3,2-b:2′,3′-d]thiophene (compound 1), 2,6-bis(5-(2-ethylhexyl)thiophen-2-yl)dithieno[3,2-b:2′,3′-d]thiophene (compound 2), and 2,6-dioctyldithieno[3,2-b:2′,3′-d]thiophene (compound 3), have been synthesized and employed as small molecular organic semiconductors for organic field-effect transistors (OFETs). All compounds exhibited good thermal stability over 290 °C, while different side groups of DTT compounds afforded differen

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21

Kathrotiya, Haresh G., and Yogesh T. Naliapara. "Synthesis of Thiophenyl Thiazole Based Novel Quinoxaline Derivatives." International Letters of Chemistry, Physics and Astronomy 51 (May 2015): 115–24. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.51.115.

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A new series of thiophenyl thiazole based novel quinoxaline derivatives 4a-4t have been synthesized by base catalysed condensation reaction. In which 6-substituted 2,3-dichloroquinoxaline 1a and 4-(thiophen-2-yl) thiazol-2-amine 2b reacted in basic condition to afford intermediate 3c which reacts with various aromatic amine to form final compounds. Easy experimental procedure, high yield, and selectivity are the imperative features of this method. The identity of all the compounds has been established by 1H NMR, 13C NMR, FT-IR, and elemental analysis.

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22

Kathrotiya, Haresh G., and Yogesh T. Naliapara. "Synthesis of Thiophenyl Thiazole Based Novel Quinoxaline Derivatives." International Letters of Chemistry, Physics and Astronomy 51 (May 15, 2015): 115–24. http://dx.doi.org/10.56431/p-oioid3.

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A new series of thiophenyl thiazole based novel quinoxaline derivatives 4a-4t have been synthesized by base catalysed condensation reaction. In which 6-substituted 2,3-dichloroquinoxaline 1a and 4-(thiophen-2-yl) thiazol-2-amine 2b reacted in basic condition to afford intermediate 3c which reacts with various aromatic amine to form final compounds. Easy experimental procedure, high yield, and selectivity are the imperative features of this method. The identity of all the compounds has been established by 1H NMR, 13C NMR, FT-IR, and elemental analysis.

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23

Safonov, A. A. "Synthesis, physico-chemical properties of 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohyd-razides." Farmatsevtychnyi zhurnal, no. 5 (August 14, 2018): 31–36. http://dx.doi.org/10.32352/0367-3057.5.16.03.

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The value of the class of 1,2,4-triazole derivatives to create a low-toxic and highly active substances is huge. There are a lot of facts about the high biological activity among a number of substances. The 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazides derivatives causes of particular interest in this direction. The aim of the work was to synthesize 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazides and their derivatives, studying of their physico-chemical properties. 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3

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24

Kim, Seongyun, Soomin Ryu, Jihae Ahn, et al. "Solution-Processable Benzo[b]thieno[2,3-d]thiophene Derivatives as Organic Semiconductors for Organic Thin-Film Transistors." Coatings 13, no. 8 (2023): 1417. http://dx.doi.org/10.3390/coatings13081417.

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Two new benzo[b]thieno[2,3-d]thiophene (BTT) derivatives, 2-(benzo[b]thiophen-5-yl)benzo[b]thieno[2,3-d]thiophene (compound 2), and 2-(benzo[b]thieno[2,3-d]thiophene-2yl)dibenzo[b,d]thiophene (compound 3) have been synthesized and utilized as solution-processable small molecular organic semiconductors for organic field-effect transistors (OFETs). The physicochemical characteristics of the recently created substances were analyzed using thermogravimetric analysis (TGA), differential scanning calorimeter (DSC), and UV-vis spectroscopy. Subsequently, the above-mentioned substances were employed a

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25

Safonov, A. A., and I. S. Nosulenko. "Antiradical activity of novel 4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol derivatives." Current issues in pharmacy and medicine: science and practice 14, no. 2 (2021): 162–66. http://dx.doi.org/10.14739/2409-2932.2021.2.230129.

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The process of studying free radicals began in the middle of the last century (the free radical theory of aging in 1956). Multiple studies have revealed the effect of free radicals on the cells of the body and the development of various diseases, such as diabetes, autoimmune diseases, diseases of the nervous system, and others. As a result, the term antioxidant has emerged, compounds that reduce and prevent the effects of free radicals. Most of the newly synthesized substances are studied for their antiradical properties. 1,2,4-Triazole derivatives are no exception, which has already proven th

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26

Wu, Hongfei, Xingxing Lu, Jingbo Xu, et al. "Design, Synthesis and Fungicidal Activity of N-(thiophen-2-yl) Nicotinamide Derivatives." Molecules 27, no. 24 (2022): 8700. http://dx.doi.org/10.3390/molecules27248700.

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Based on the modification of natural products and the active substructure splicing method, a series of new N-(thiophen-2-yl) nicotinamide derivatives were designed and synthesized by splicing the nitrogen-containing heterocycle natural molecule nicotinic acid and the sulfur-containing heterocycle thiophene. The structures of the target compounds were identified through 1H NMR, 13C NMR and HRMS spectra. The in vivo bioassay results of all the compounds against cucumber downy mildew (CDM, Pseudoperonospora cubensis (Berk.et Curt.) Rostov.) in a greenhouse indicated that compounds 4a (EC50 = 4.69

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27

Wardakhan, Wagnat Wahba, El-Sayed Nahed Nasser Eid, and Rafat Milad Mohareb. "Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives." Acta Pharmaceutica 63, no. 1 (2013): 45–57. http://dx.doi.org/10.2478/acph-2013-0004.

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The reaction of cyclopentanone with cyanoacetylhydrazine gave 2-cyano-2-cyclopentylideneacetohydrazide (1). Treatment of compound 1 with elemental sulphur in the presence of triethylamine afforded 2-amino-5,6-dihydro- -4H-cyclopenta[b]thiophene-3-carbohydrazide (2), which in-turn formed the corresponding intermediate diazonium salt. The latter was coupled with either ethyl cyanoacetate or ethyl acetoacetate to form 2-cyano-2-(3-(hydrazinecarbonyl)- 5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)hydrazono) acetate (3) and ethyl 2-(2-(3-(hydrazinecarbonyl)-5,6-dihydro- 4H-cyclopenta[b]thiophen-2-yl)h

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28

Rinkes, I. J. "Researches on Thiophen Derivatives. (1st. Communication)." Recueil des Travaux Chimiques des Pays-Bas 51, no. 12 (2010): 1134–42. http://dx.doi.org/10.1002/recl.19320511205.

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Rinkes, I. J. "Researches on thiophen derivatives: 2nd. Communication." Recueil des Travaux Chimiques des Pays-Bas 52, no. 7 (2010): 538–48. http://dx.doi.org/10.1002/recl.19330520702.

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Rinkes, I. J. "Researches on thiophen derivatives. 3rd. communication." Recueil des Travaux Chimiques des Pays-Bas 52, no. 12 (2010): 1052–60. http://dx.doi.org/10.1002/recl.19330521210.

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31

Pandian Amuthavalli, Ayyachamy, Babu Prakash, David Edison, and Rajendran Velmurugan. "Synthesis, Spectral Analysis, Molecular Docking and Biological Evaluation of Cyclohepta[b]indole Derivatives." Croatica chemica acta 92, no. 3 (2019): 347–56. http://dx.doi.org/10.5562/cca3375.

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A new series of specifically substituted cyclohepta[b]indole derivatives from the precursor thiophen-2-ylmethylene has been synthesized. The structures of synthesized derivatives were established by spectral and elemental analyses. The docking studies with protein kinase CK2 was performed, derivative 6c exhibited the most excellent glide and E model score of –7.61 and –58.27, respectively. In-vitro anticancer activity against cervical cancer cell line (HeLa) was studied. The IC50 values were compared with the standard drug Ellipticine. Compounds 5c, 6c and 6d showed better IC50 value when comp

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32

Matiichuk, Yulia, Yuriy Horak, Taras Chaban, Ihor Chaban, and Vasyl Matiychuk. "Synthesis and anticancer properties of 3-furan-2-yl-2-(4-furan/thiophen-2-ylthiazol-2-yl)acrylonitrile derivatives." Current Chemistry Letters 11, no. 3 (2022): 269–74. http://dx.doi.org/10.5267/j.ccl.2022.4.002.

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By the reaction of (4-furan-2-yl-thiazol-2-yl)- 3a and (4-thiophen-2-yl-thiazol-2-yl)- 3b acetonitriles with furfural 4 and 5-arylfurfyrals 5a-g 3-furan-2-yl-2-(4-furan/thiophen-2-ylthiazol-2-yl)acrylonitrile derivatives 6a-i were obtained. Anticancer activity screening was carried out within the framework of Developmental Therapeutic Program of the National Cancer Institute's (DTP, NCI, Bethesda, Maryland, USA). It was found out that (2E)-3-(2-furyl)-2-[4-(2-furyl)-1,3-thiazol-2-yl]acrylonitrile (6a) and 2-(4-thiophen-2-yl-thiazol-2-yl)-acrylonitriles 6h,i possessed low activity and 2-(4-fura

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33

Szabadai, Rebecca S., Jesse Roth-Barton, Kenneth P. Ghiggino, Jonathan M. White, and David J. D. Wilson. "Solvatochromism in Diketopyrrolopyrrole Derivatives: Experimental and Computational Studies." Australian Journal of Chemistry 67, no. 9 (2014): 1330. http://dx.doi.org/10.1071/ch14057.

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A series of seven thiophen-substituted diketopyrrolopyrrole derivatives were synthesised and their solution absorption spectra characterised in a range of solvents of varying polarity. The absorption spectra of these diketopyrrolopyrrole derivatives exhibited significant negative solvatochromism. The behaviour is consistent with results of time-dependent density-functional theory calculations of excitation energies. Calculated electronic structures suggest that there is significant charge transfer between the electron-donating thiophen substituents and the diketopyrrolopyrrole core but that th

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Moloney, Gerard P., James A. Angus, Alan D. Robertson, et al. "Synthesis and Cannabinoid Activity of a Variety of 2,3-Substituted 1-Benzo[b]thiophen Derivatives and 2,3-Substituted Benzofuran: Novel Agonists for the CB1 Receptor." Australian Journal of Chemistry 61, no. 7 (2008): 484. http://dx.doi.org/10.1071/ch07412.

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An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB1 agonists. It is hoped that compounds of this type will have clinical utility in pain control and cerebral ischaemia following stroke or traumatic head injury. We report here medicinal chemistry studies directed towards the investigation of several classes of 1-benzo[b]thiophen and benzofuran derivatives as novel CB1 agonists. We have discovered a novel series of compounds, which contain a 1-benzo[b]thiophen or a benzofuran group as the central aromatic group. Our investigation of this ser

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35

Shilpa A.S and Satish Kumar.M. "Synthesis of (1-(2-((5-(4-Substitutedphenyl) Furan/Thiophen-2-Yl) Methylene) Hydrazineyl)-3-(4-Hydroxyphenyl)-1-Oxopropan-2-Yl)-4-(1H-Indol-3-Yl) Butanamide and It’s Pharmacological Studies." Journal of Advanced Zoology 44, S-5 (2023): 1978–84. http://dx.doi.org/10.17762/jaz.v44is-5.1573.

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A series of (1-(2-((5-(4-substitutedphenyl) furan/thiophen-2-yl) methylene) hydrazineyl)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-4-(1H-indol-3-yl) butanamide is synthesised and screened for antinflammatory activity by using Dexamethasone as a standard drug. Among the Screened derivatives bromine substituted and methyl substituted derivatives showed higher activity than other derivatives.

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36

Harishkumar, S. and Satyanarayan ND*. "DNA CLEAVAGE POTENTIAL OF 4-(PIPERIDIN-1- YLMETHYL)-2-(THIOPHEN-2-YL) QUINOLINE ANALOGUES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 2023–26. https://doi.org/10.5281/zenodo.1214503.

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DNA cleavage potential of 4-(piperidin-1-ylmethyl)-2-(thiophen-2-yl) quinoline 7(a-j) derivatives, were studied on Calf-thymus DNA by agarose gel electrophoresis method. The compounds 7e and 7j have exhibited almost complete cleavage, whereas the other compounds 7a, 7b, 7c, 7d, 7f, 7g and 7i have shown partial cleavage of DNA at 100 μg concentration. The compounds 7e and 7j can be considered as DNA intercalating agents due to its planarity and their potentiality to cleave the DNA completely. This might be through breaking the base pairs of DNA. Keywords: DNA, Calf-thymus DNA, Thiophene, Aga

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37

Safonov, A. A. "Synthesis, physico-chemical properties of derivatives 3-(alkylthio)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-4-amine." Farmatsevtychnyi zhurnal, no. 3-4 (August 14, 2018): 50–54. http://dx.doi.org/10.32352/0367-3057.3-4.16.03.

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Recently, the search for new compounds with high biological activity, which can be the basis for potential drugs, becomes topical for world scientists. A heterocyclic compound cause particular interest in this area as highly pharmacologically active compounds. Scientists extends interest due to the low toxicity and high reactivity 1,2,4-triazole of the system. It is proved that the combination of triazole nucleus with other heterocyclic systems, especially in the fifth position, causes increased biological effect, and, sometimes, the appearance of new pharmacological activities. The aim

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38

Robinson, Jenifer, Chandra Mohan, and Pooja Gulati. "Synthesis and antibacterial screening of new quinazoline derivatives from 8-bromo-2- chloroquinazoline scaffold." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 569. https://doi.org/10.59467/ijhc.2025.35.569.

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In the present study, four new quinazoline derivatives, namely, N-(4-(4-(2-(dimethylamino)ethyl)piperazin- 1-yl)phenyl)-8-(thiophen-2-yl)quinazolin-2-amine (4a), N-(4-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)phenyl)-8-(1- methyl-1H-pyrazol-4-yl)quinazolin-2-amine (4b), N-(4-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)phenyl)-8-benzo[b] thien-2-ylquinazolin-2-amine (4c) and N-(4-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)phenyl)-8-phenylquinazolin- 2-amine (4d) were synthesized using palladium-catalyzed cross-coupling reactions. The structures of the synthesized compounds were confirmed by absorp

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39

Uchida, Manabu, and Masahiro Irie. "Photochromic Chromene Derivatives with a Thiophen Moiety." Chemistry Letters 21, no. 11 (1992): 2257–60. http://dx.doi.org/10.1246/cl.1992.2257.

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40

Katzsch, Felix, Tobias Gruber, and Edwin Weber. "Crystal structures of functional building blocks derived from bis(benzo[b]thiophen-2-yl)methane." Acta Crystallographica Section C Structural Chemistry 72, no. 9 (2016): 679–84. http://dx.doi.org/10.1107/s2053229616012973.

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The syntheses of three bis(benzo[b]thiophen-2-yl)methane derivatives, namely bis(benzo[b]thiophen-2-yl)methanone, C17H10OS2, (I), 1,1-bis(benzo[b]thiophen-2-yl)-3-(trimethylsilyl)prop-2-yn-1-ol, C22H20OS2Si, (II), and 1,1-bis(benzo[b]thiophen-2-yl)prop-2-yn-1-ol, C19H12OS2, (III), are described and their crystal structures discussed comparatively. The conformation of ketone (I) and the respective analogues are rather similar for most of the compounds compared. This is true for the interplanar angles, the Caryl—Cbridge—Carylangles and the dihedral angles. The best resemblance is found for a bio

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41

Kut, D., M. M. Kut, and R. T. Mariychuk. "SYNTHESIS OF N-ALKENYL(ALKYNYL)-5,6-DIMETHYL-2-(THIOPHEN-2-YL)THIENO[2,3-d]PYRIMIDIN-4-AMINES AND THEIR IN SILICO STUDY ON GROUP II CHITINASE (ChtII) INHIBITION." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 52, no. 2 (2024): 75–82. https://doi.org/10.24144/2414-0260.2024.2.75-82.

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Research in the chemistry of heterocyclic compounds, particularly condensed pyrimidine frameworks, aimed at developing drugs with diverse therapeutic properties. Among these compounds, special attention is given to thieno[2,3-d]pyrimidine derivatives due to their potential as drug candidates. This study presents the synthesis of a series of N-alkenyl(alkynyl)-5,6-dimethyl-2-(thiophen-2-yl)-thieno[2,3-d]pyrimidin-4-amines via the amination reaction of 5,6-dimethyl-2-(thiophen-2-yl)-4-chlorothieno[2,3-d]pyrimidine with unsaturated amines (allyl-, diallyl-, and propargylamine), enabling potential

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42

Liu, Fu De, Yong Zhou, and Hai Yan Wu. "Synthesis and Characterization of Copolymers Consisting of 3-Hexylthiophene and Biphenyl Derivatives." Applied Mechanics and Materials 331 (July 2013): 478–82. http://dx.doi.org/10.4028/www.scientific.net/amm.331.478.

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Two novel copolymers consisting of 3-hexylthiophene and 4,4-di (thiophen-2-yl) biphenyl (DTBHT) or 4,4-di (thiophen-2-yl)-2-nitrobiphenyl (DTNHT) were synthesized. Both of the copolymers show lower HOMO energy level (-5.62, -5.51 eV) than that of the P3HT (-5.1 eV). Compared to DTBHT, adding nitro group in DTNHT improves effective conjugation of the main chain and successfully lowers the electrochemical bandgap of the copolymers from 2.39 to 2.28 eV and optical band-gap from 2.17 to 2.07 eV with significant increase in fluorescence quantum yield from 0.140 to 0.252. Keywords: biphenyl, 3-Hexyl

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43

Marwa A. Atiyah, Olfat A. Nief, and Abdulkader M. Noori. "New Pyrazolines with Imine Moiety: Synthesis, Characterization." Tikrit Journal of Pure Science 26, no. 5 (2021): 40–47. http://dx.doi.org/10.25130/tjps.v26i5.175.

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Chalcone was prepared by claisen- schmidt condensation between reaction equivalent moles from 4-amino acetophenone with thiophen -2-carboxaldehyde in presence sodium hydroxide as base, the mechanism was involved the abstraction α Proton by base from the α-carbon of the ketone to form carbanion, which attacks carbonyl of aldehyde contains no α-hydrogens to produce α-β-unsaturated ketone, Chalcone derivative used to synthesize pyrazoline derivatives by condensation with 2,4-dinitro phenyl hydrazine. The newly synthesized compounds were determined using spectroscopic methods such as FTIR, Mass sp

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44

Pei, Mingyuan, Kwang Hun Park, Mi Jang та ін. "Control of consistent ordering in π-conjugated polymer films for organic field-effect transistor applications". RSC Advances 6, № 75 (2016): 70733–39. http://dx.doi.org/10.1039/c6ra14677e.

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A conjugated copolymer, pDPP-(TV)<sub>2</sub>B-2DO, including donor and acceptor blocks of 1,4-bis((E)-2-(thiophen-2-yl)vinyl)benzene and diketopyrrolopyrrole derivatives, respectively, was synthesized for organic field-effect transistor applications.

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45

Amr, Abd El-Galil E., Alhussein A. Ibrahimd, Mohamed F. El-Shehry, Hanaa M. Hosni, Ahmed A. Fayed, and Elsayed A. Elsayed. "In Vitro and In Vivo Anti-Breast Cancer Activities of Some Newly Synthesized 5-(thiophen-2-yl)thieno-[2,3-d]pyrimidin-4-one Candidates." Molecules 24, no. 12 (2019): 2255. http://dx.doi.org/10.3390/molecules24122255.

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In this study, some of new thiophenyl thienopyrimidinone derivatives 2–15 were prepared and tested as anti-cancer agents by using thiophenyl thieno[2,3-d]pyrimidinone derivative 2 as a starting material, which was prepared from cyclization of ethyl ester derivative 1 with formamide. Treatment of 2 with ethyl- chloroacetate gave thienopyrimidinone N-ethylacetate 3, which was reacted with hydrazine hydrate or anthranilic acid to afford acetohydrazide 4 and benzo[d][1,3]oxazin-4-one 5, respectively. Condensation of 4 with aromatic aldehydes or phenylisothiocyanate yielded Schiff base derivatives

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46

Abdo, Nadia Y. Megally, Rafat M. Mohareb, and Waleed N. Al-darkazali. "Heterocyclization of 2-Arylidenecyclohexan-1,3-dione: Synthesis of Thiophene, Thiazole, and Isoxazole Derivatives with Potential Antitumor Activities." Anti-Cancer Agents in Medicinal Chemistry 20, no. 3 (2020): 335–45. http://dx.doi.org/10.2174/1871520619666190730103425.

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Background: Thiophene, thiazole, and isoxazole derivatives are present in a wide range of natural and synthetic compounds with heterogeneous pharmacological activity. Due to their structural diversity, they are some of the most versatile classes of compounds for anticancer drug design and discovery. Objective: Thiophene, thiazole, and isoxazole derivatives were herein designed with a dual purpose: as antiproliferative agents and kinase inhibitors. Methods: The test compounds were synthesized in moderate to high yields through a simple methodology. Tetrahydrobenzo[b]thiophen-5-one derivatives 5

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Kaneria, Ankur A., Nilesh M. Thumar, Kartik D. Ladva, and Milan S. Vadodaria. "Synthesis, Characterization and Antimicrobial Activities of some Novel 3-(4-Bromobenzyl)-5-(Thiophen-2-yl)-4H-1,2,4-Triazol Derivatives." International Letters of Chemistry, Physics and Astronomy 68 (July 2016): 10–17. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.68.10.

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A convenient and promising synthesis of 4-(alkyl/aryl)- 3-(4-bromobenzyl)-5-(thiophen-2-yl)-4H-1,2,4-triazol was carried out by the reaction of 2-(4-bromobenzyl)-5-(thiophen-2-yl)-1,3,4-oxadiazole with different aliphatic/aromatic primary amine without any solvent. The newly synthesized compound were characterized by1H NMR, IR and Mass spectroscopy and also screened for their antimicrobial activity against various strains of bacteria and fungi.

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48

Kaneria, Ankur A., Nilesh M. Thumar, Kartik D. Ladva, and Milan S. Vadodaria. "Synthesis, Characterization and Antimicrobial Activities of some Novel 3-(4-Bromobenzyl)-5-(Thiophen-2-yl)-4H-1,2,4-Triazol Derivatives." International Letters of Chemistry, Physics and Astronomy 68 (July 19, 2016): 10–17. http://dx.doi.org/10.56431/p-b6o1gb.

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A convenient and promising synthesis of 4-(alkyl/aryl)- 3-(4-bromobenzyl)-5-(thiophen-2-yl)-4H-1,2,4-triazol was carried out by the reaction of 2-(4-bromobenzyl)-5-(thiophen-2-yl)-1,3,4-oxadiazole with different aliphatic/aromatic primary amine without any solvent. The newly synthesized compound were characterized by 1H NMR, IR and Mass spectroscopy and also screened for their antimicrobial activity against various strains of bacteria and fungi.

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49

Rajni Swamy, V., P. Gunasekaran, R. V. Krishnakumar, N. Srinivasan, and P. Müller. "Crystal structure of [4-(2-methoxyphenyl)-3-methyl-1-phenyl-6-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-5-yl](thiophen-2-yl)methanone." Acta Crystallographica Section E Structure Reports Online 70, no. 9 (2014): o974—o975. http://dx.doi.org/10.1107/s1600536814017437.

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The title compound, C26H18F3N3O2S, a 2-methoxy-substituted derivative, is closely related to its 4-methyl- and 4-chloro-substituted analogues and yet displays no structural relationships with them. The thiophene ring is disorder free and the –CF3group exhibits disorder, respectively, in contrast and similar to that observed in the 4-methyl- and 4-chloro-substituted derivatives. The torsion angle which defines the twist of the thiophene ring is −69.6 (2)° (gauche) in the title compound, whereas it is anticlinal in the 4-methyl- and 4-chloro-substituted derivatives, with respective values of 99.

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50

Mei, Qunbo, Ruqiang Tian, Yujie Shi, Qingfang Hua, Chen Chen, and Bihai Tong. "A series of selective and sensitive fluorescent sensors based on a thiophen-2-yl-benzothiazole unit for Hg2+." New Journal of Chemistry 40, no. 3 (2016): 2333–42. http://dx.doi.org/10.1039/c5nj02259b.

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Different types of fluorescent probes for Hg<sup>2+</sup> based on the 5-thiophen-2-yl-benzothiazole derivatives (TBT, CTBT, DTBT and NTBT) were realized by changing the subsituents, including the fluorescence quenching probe, the fluorescence enhancement probe and the ratiometric fluorescent probe.

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