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Relevant bibliographies by topics / Thiopyrimidines

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Academic literature on the topic 'Thiopyrimidines'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Thiopyrimidines"

1

Coulibali, Siomenan, Souleymane Coulibaly, Patrick-Armand Achi, Kouassi Yves Guillaume Sissouma Drissa Molou, and Ané Adjou. "Synthesis of New Thiazolopyrimidines and 2-Alkylthiopyrimidines Derivatives." Pharmaceutical and Chemical Journal 9, no. 1 (2022): 5–10. https://doi.org/10.5281/zenodo.13970008.

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In this work, we reported the synthesis of derivative’s 2-thiopyrimidine substituted on the positions -1 and -2 by the alkyl groups. The bicyclic scaffold (<strong>6a</strong> and <strong>6b</strong>) were obtained via condensation of 2-thiopyrimidines (<strong>4a</strong> and <strong>4b</strong>) with dihalogenated ethane <strong>5</strong> in the presence of potassium carbonate<strong>.</strong> We got the 2-thioalkylpyrimidine derivatives (<strong>8a</strong>-<strong>f</strong>) with the same workup, condensing halogenated alkyls <strong>7</strong> with 2-thiopyrimidines (<strong>4a</

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2

Sharma, Dolly, Vinit Kumar, and Reshma Rani. "Design, synthesis, in silico ADME/T profiling of pseudo-pyrimidine derivatives and anticancer activity evaluation." Research Journal of Chemistry and Environment 26, no. 8 (2022): 30–37. http://dx.doi.org/10.25303/2608rjce30037.

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Pyrimidines are aromatic heterocyclic nitrogenous bases predominantly present as integral building blocks of DNA and RNA. The alternating single and double bonds connecting the C and N atoms in these 6-membered heterocyclic rings confer them to resonance, aromaticity and exceptional stability. The prevalence of pyrimidine derivatives in nucleic acids, vitamins, amino acids, antibiotics, alkaloids and several reported bioactive compounds promoted investigation of their novel biological roles which eventually demonstrated a plethora of medicinal advantages of the pyrimidine scaffold by virtue of

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3

Vendrell-Criado, Victoria, Jose A. Sáez, Virginie Lhiaubet-Vallet, M. Consuelo Cuquerella, and Miguel A. Miranda. "Photophysical properties of 5-substituted 2-thiopyrimidines." Photochemical & Photobiological Sciences 12, no. 8 (2013): 1460. http://dx.doi.org/10.1039/c3pp50058f.

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4

Salieva, Gulrukh, Malokhat Uktamova, Kohei Torikai, and Tursunali Kholikov. "2-(Heptylthio)pyrimidine-4,6-diamine." Molbank 2025, no. 1 (2025): M1965. https://doi.org/10.3390/m1965.

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Thiopyrimidines represent one of the most active classes of compounds, possessing a wide spectrum of biological activities. Herein, we report the synthesis of 2-(heptylthio)pyrimidine-4,6-diamine (HPDA) via S-alkylation. The structure of HPDA was elucidated using 1H and 13C nuclear magnetic resonance (NMR), heteronuclear multiple bond correlation (HMBC), high resolution mass (HRMS), and infrared (IR) spectroscopies.

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5

Wanare, Rajendra Krushnaji. "A Novel and Facile Synthesis of Thiopyrimidines and O-Glucosides." Asian Journal of Organic & Medicinal Chemistry 4, no. 2 (2019): 65–69. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p161.

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Reaction of 3-methyl-5-(3'-aryl prop-2'-enoyl)-1,2-benzisoxazole (1a-j) with thiourea and alcoholic solution of KOH afforded 3-methyl-5-(4'-aryl-2'-thiopyrimidin-6'-yl)-1,2-benzisoxazoles (2a-j). Oxidation of products 2a-j using alkaline KMnO4 solution produces 5-(4'-aryl-2'-thiopyrimidin-6'-yl)-1,2-benzisoxazole-3-carboxylic acids (3a-j). Condensation of products 3a-j with 2,3,4,6-tetra-Oacetyl-α-D-glucopyranosyl bromide (TAGBr), the glucosylating agent synthesized 3-(2,3,4,6-tetra-O-acetyl-3-acetyl-β-D-glucopyranosyl)-5-(4'-aryl-2'-thiopyrimidin-6'-yl)-1,2-benzisoxazoles (4a-j). Subsequent d

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6

Hammerland, Lance G., Martin Johansson, Jonas Malmström, et al. "Structure–activity relationship of thiopyrimidines as mGluR5 antagonists." Bioorganic & Medicinal Chemistry Letters 16, no. 9 (2006): 2467–69. http://dx.doi.org/10.1016/j.bmcl.2006.01.100.

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7

Sánchez, M. P. Sánchez, J. M. Salas Peregrin, M. A. Romero Molina, E. Colacio Rodríguez, and M. Moreno Carretero. "Thermal studies on metal complexes of 2-thiopyrimidines." Thermochimica Acta 93 (September 1985): 77–80. http://dx.doi.org/10.1016/0040-6031(85)85020-6.

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8

Simenel, Alexander A., Galina A. Dokuchaeva, Lubov' V. Snegur, et al. "Ferrocene-modified thiopyrimidines: synthesis, enantiomeric resolution, antitumor activity." Applied Organometallic Chemistry 25, no. 1 (2010): 70–75. http://dx.doi.org/10.1002/aoc.1691.

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9

S, A. MORKHADE, and N. INGLE V. "Synthesis of a few New 2'-Hydroxy-2-benzoyl-3- arylacrylophenones, 3-Benzoyl-2-arylchromones and 5-Benzoyl-1 ,2-dihydro-4-(2-hydroxyphenyl)- 6-aryl-2-thiopyrimidines." Journal of Indian Chemical Society Vol. 66, JAN 1989 (1989): 37–38. https://doi.org/10.5281/zenodo.5948117.

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Department of Chemistry, Nagpur University, Nagpur- 440010 <em>Manuscript received 1 June 1987, revised 27 July 1988, accepted 23 September 1988</em> 2<em>'</em>-Hydroxy-2-benzoyl-3-arylacrylophenones (2) have been prepared by the condensation of appropriate <strong>. </strong>β-diketone (1) and aromatic aldehyde. The acrylophenones thus obtained were oxidised with SeO<sub>2</sub>, to get the respective 3-benzoyl-2-arylchromones (3). These on reaction with thiourea gave 5-benzoyl-1,2-dihydro-4-(2-hydroxyphenyl)-6- aryl-2-thlopyridines (4). The identification of these compounds ha

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10

Metwally, M. A., E. Abdel-Galil, F. A. Amer, and A. M. Abdallah. "New Thiazolidinones, Thiazolines and Thiopyrimidines from 3,5-Diphenylcyclohex-2-enone." American Journal of Organic Chemistry 2, no. 1 (2012): 28–34. http://dx.doi.org/10.5923/j.ajoc.20120201.06.

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Conference papers on the topic "Thiopyrimidines"

1

Karpenko, Yuriy. "Absorption of Free Radicals of New S-Derivatives (1,2,4-Triazole-3(2H)-yl)methyl)thiopyrimidines." In ECSOC 2024. MDPI, 2024. https://doi.org/10.3390/ecsoc-28-20181.

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2

Karpenko, Yu V. "Study of acute toxicity on Danio rerio hydrobionts of new s-derivatives (1,2,4-triazol-3(2H)-il)methyl)thiopyrimidines." In DEVELOPMENT OF THE HEALTHCARE SECTOR IN UKRAINE: THE PATH TOWARDS THE EUROPEAN UNION. Baltija Publishing, 2023. http://dx.doi.org/10.30525/978-9934-26-387-3-15.

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