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Journal articles on the topic 'Thiourea derivatives'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Ngaini, Zainab, Wan Sharifatun Handayani Wan Zulkiplee, and Ainaa Nadiah Abd Halim. "One-Pot Multicomponent Synthesis of Thiourea Derivatives in Cyclotriphosphazenes Moieties." Journal of Chemistry 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/1509129.

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In this study, hexasubstituted thiourea was carried out via reaction of isothiocyanato cyclophosphazene intermediates with a series of aromatics amines and amino acids in a one-pot reaction system. The reaction was not as straightforward as typical thiourea synthesis. Six unexpected thiourea derivatives3a–fwere formed in the presence of cyclotriphosphazene moieties in good yields (53–82%). The structures of3a–fwere characterized by elemental analysis and FTIR,1H,13C, and31P NMR spectroscopies. The occurrence of reverse thioureas formation in a one-pot reaction system is discussed. The possible

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2

Al-Riyahee, Ali A. A. "First Row Transition Metal Complexes Derived from N, Nʹ-Substituted Thiourea: Synthesis, Geometrical Structures and Cyclic Voltammetry Probe: A Review". BASRA JOURNAL OF SCIENCE 39, № 1 (2021): 96–118. http://dx.doi.org/10.29072/basjs.202117.

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Thioureas or thiourea derivatives as organosulfur compounds are one of the most widely used ligands in different applications as we are going to discuss it extensively such as in coordination chemistry by involving them to rich sources of N, O and S atoms coordinating through S atom, S and O atoms in benzoyl derivatives or S, O and N atoms in pyridyl hetrocylic benzoyl derivatives. These hard and soft donor sites facilitate the bonding between thiourea free ligand and metal ion through one or more to make ligands behave as mono, bi or multidentate ligands to form huge and stable series of the

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3

Elshaier, Yaseen A. M. M., Ashraf A. Aly, Mohamed Abdel-Aziz, et al. "Synthesis and Identification of New N,N-Disubstituted Thiourea, and Thiazolidinone Scaffolds Based on Quinolone Moiety as Urease Inhibitor." Molecules 27, no. 20 (2022): 7126. http://dx.doi.org/10.3390/molecules27207126.

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Synthesis of thiazolidinone based on quinolone moiety was established starting from 4-hydroxyquinol-2-ones. The strategy started with the reaction of ethyl bromoacetate with 4-hydroxyquinoline to give the corresponding ethyl oxoquinolinyl acetates, which reacted with hydrazine hydrate to afford the hydrazide derivatives. Subsequently, hydrazides reacted with isothiocyanate derivatives to give the corresponding N,N-disubstituted thioureas. Finally, on subjecting the N,N-disubstituted thioureas with dialkyl acetylenedicarboxylates, cyclization occurred, and thiazolidinone derivatives were obtain

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4

Binzet, Gun, Bülent Zeybek, Esma Kılıç, Nevzat Külcü, and Hakan Arslan. "Determination of the Ionization Constants of Some Benzoyl Thiourea Derivatives in Dioxane-Water Mixture." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/201238.

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The stoichiometric ionization constants ofN,N-dialkyl-N′-(4-substituted benzoyl) thiourea (Substitutes: H, Cl, and Br; alkyl groups: ethyl,n-propyl,n-butyl, and phenyl) derivatives have been determined potentiometrically in dioxane-water (v:v, 50:50) mixture at ionic strength of 0.1 M and25.0±0.1°C. The ionization constants were calculated with the BEST computer program and the formation curves using the data obtained from the potentiometric titrations. The effects of substituents and alkyl groups on the ionization constants of the benzoyl thiourea derivatives have been investigated. A compari

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5

Makhsumov, Abduhamid, Yusubjon Holboyev, Nailya Valeeva, Boburbek Ismailov, and Ibragim Askarov. "Synthesis of 1-nicotinoylo-3-(meta-nitrophenyl)- thiourea derivatives with anti-inflammatory activity." E3S Web of Conferences 434 (2023): 02032. http://dx.doi.org/10.1051/e3sconf/202343402032.

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Thiourea derivatives are used in many industries: medicine, agriculture, engineering, rubber industry, organic synthesis. On their basis, various preparations for the needs of the national economy were obtained. The latest studies of thiourea derivatives, carried out at the present time, are prompted not only by theoretical, but also by practical needs. From this point of view, thiourea derivatives are of undoubted interest in substances with different biological activities. They are widely used in agriculture and have been used as herbicides, fungicides, insecticides, bactericides, dyes, grow

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6

Kovalskaya, A. V., A. N. Lobov, V. V. Zarubaev, and I. P. Tsypysheva. "Derivatives of (–)-Cytisine with Thiourea Fragment. Synthesis and Antiviral Activity." Žurnal obŝej himii 94, no. 6 (2024): 712–21. http://dx.doi.org/10.31857/s0044460x24060054.

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New derivatives of the quinolizidine alkaloid, (–)-cytisine, with a substituted 2-pyridone ring and a thiourea moiety in the bispidin fragment of the molecule were synthesized. The ability of the synthesized cytisine-containing thioureas to inhibit the reproduction of human parainfluenza virus type 3 was assessed. It was found that the derivatives obtained by the reaction of benzoyl or phenyl isothiocyanate with (–)-cytisine, as well as its 9-bromo or 9,11-derivative, effectively suppress the reproduction of human parainfluenza virus type 3 (their selectivity indices are 56, 58 and 95, respect

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7

Viana, Gil Mendes, Edézio Ferreira da Cunha-Junior, Paloma Wetler Meireles Carreiros Assumpção, et al. "Synthesis and Structure–Activity Relationship of Thiourea Derivatives Against Leishmania amazonensis." Pharmaceuticals 17, no. 12 (2024): 1573. http://dx.doi.org/10.3390/ph17121573.

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Background: Leishmaniasis, caused by Leishmania protozoa and transmitted by vectors, presents varied clinical manifestations based on parasite species and host immunity. The lack of effective vaccines or treatments has prompted research into new therapies, including thiourea derivatives, which have demonstrated antiprotozoal activities. Methods: We synthesized two series of N,N′-disubstituted thiourea derivatives through the reaction of isothiocyanates with amines. These compounds were evaluated in vitro against promastigote and amastigote forms of L. amazonensis, alongside cytotoxicity assess

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8

Binzet, Gün, Gülten Kavak, Nevzat Külcü, Süheyla Özbey, Ulrich Flörke, and Hakan Arslan. "Synthesis and Characterization of Novel Thiourea Derivatives and Their Nickel and Copper Complexes." Journal of Chemistry 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/536562.

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New benzoyl thiourea derivatives and their nickel and copper complexes were synthesized. The structure of the synthesized compounds were confirmed by elemental analysis, FT-IR, and1H NMR techniques. Four of the synthesized compounds are analyzed by X-ray single crystal diffraction technique. WhereasN,N-dimethyl-N′-(4-fluorobenzoyl)thiourea,N,N-diethyl-N′-(4-fluorobenzoyl)thiourea, andN,N-di-n-butyl-N′-(4-fluorobenzoyl) thiourea crystallize in the monoclinic system,bis(N,N-di-n-propyl-N′-(4-fluorobenzoyl)thioureato) nickel(II) complex crystallizes in the triclinic system. These ligand molecules

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9

Venkatachalam, TK, Elise A. Sudbeck, Chen Mao, and Fatih M. Uckun. "Piperidinylethyl, Phenoxyethyl and Fluoroethyl Bromopyridyl Thiourea Compounds with Potent Anti-HIV Activity." Antiviral Chemistry and Chemotherapy 11, no. 5 (2000): 329–36. http://dx.doi.org/10.1177/095632020001100503.

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Derivatives of piperidinylethyl, phenoxyethyl and fluoroethyl bromopyridyl thioureas were designed and synthesized as non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1 reverse transcriptase (RT). The anti-HIV activity of these compounds was examined by determining their ability to inhibit the replication of the HIV-1 strain HTLVIIIB in human peripheral blood mononuclear cells. The unsubstituted parent pyridyl thiourea compound N-[2-(1-piperidine)ethyl]-N′-[2-(pyridyl)] thiourea (1) exhibited no anti-HIV activity, even at 100 μM. However, the thiourea derivatives that contain a

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10

Erol Günal, Şule, and Engin Kaplan. "SYNTHESIS, EVALUATION OF ANTIFUNGAL ACTIVITY AND DRUG-LIKENESS OF BENZOYL THIOUREA DERIVATIVES." İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi 24, no. 47 (2025): 217–28. https://doi.org/10.55071/ticaretfbd.1588118.

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Herein, we report the synthesis of a series of 2-bromobenzoyl-substituted thiourea derivatives. The structures of the synthesized thioureas were characterized by spectroscopic methods. These derivatives, together with 2-fluorobenzoyl thioureas synthesized previously, have been evaluated for their potential antifungal activity. Compounds 2d and 2f showed antifungal activity against Candida albicans. Compound 2f also demonstrated activity against C. parapsilosis. Drug-likeness properties of the compounds were also estimated, and it was found that all compounds showed good drug-likeness propertie

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11

Gonçalves, Itamar L., Rafaela R. da Rosa, Vera L. Eifler-Lima, and Aloir A. Merlo. "The use of isoxazoline and isoxazole scaffolding in the design of novel thiourea and amide liquid-crystalline compounds." Beilstein Journal of Organic Chemistry 16 (February 6, 2020): 175–84. http://dx.doi.org/10.3762/bjoc.16.20.

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A series of novel thiourea and amide liquid crystals containing 5-membered isoxazoline and isoxazole rings were synthetized and the liquid crystal properties studied. Thioureas were obtained using a condensation reaction of benzoyl chlorides, arylamines and ammonium thiocyanate. The amides, on the other hand, were the byproduct of a quantitative reaction which used potassium cyanate as the starting material. Thiourea and amide derivatives were predominantly SmA mesophase inductors. A nematic mesophase was observed only for thioureas and amides containing an isoxazole ring. Additionaly, the liq

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12

Stefańska, Joanna, Karolina Stępień, Anna Bielenica, Małgorzata Wrzosek, and Marta Struga. "Antistaphylococcal Activity of Selected Thiourea Derivatives." Polish Journal of Microbiology 65, no. 4 (2016): 451–60. http://dx.doi.org/10.5604/17331331.1227671.

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Five of thiourea derivatives were prepared using as a starting compound 3-(trifluoromethyl)aniline, 4-chloro-3-nitroaniline, 1,3-thiazol-2-amine, 2H-1,2,3-triazol-4-amine and commercial isothiocyanates. All compounds were evaluated in vitro for antimicrobial activity. Derivatives 2 and 3 showed the highest inhibition against Gram-positive cocci (standard and hospital strains). The observed MIC values were in the range of 0.5–8 μg/ml. The products effectively inhibited the formation of biofilms of methicillin-resistant and standard strains of Staphylococcus epidermidis. Inhibitory activity of t

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13

B., C. JOSHI, GOGIA SANTOSH, and KISHORE DHARMA. "Conversion of Thiochroman-4-one into the corresponding Spiro-thiazole and -pyrimidine Derivatives." Journal of Indian Chemical Society Vol. 65, Apr 1988 (1988): 280–81. https://doi.org/10.5281/zenodo.6035800.

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Chemistry Department, University of Rajasthan, Jaipur-302 004 Chemistry Department, Banasthali Vidyapith, Banasthali-304 022 <em>Manuscript received 9 September 1987, revised 20 January 1988, accepted 27 </em>January <em>1988</em> Reaction of cysteine and 2-aminothiophenol with thiochroman-4-one gives thiazoline and benzothiazoline derivatives 1 and 2, respectively. Thiochroman-4-one with bromine and thiourea forms 2-aminothiazole derivative (3). Thiochroman-4-one with urea and thiourea in the presence of benzaldehyde gives pyrimidine derivatives 4 and 5, respectively.  

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14

Andrés, José M., Miriam Ceballos, Alicia Maestro, Isabel Sanz, and Rafael Pedrosa. "Supported bifunctional thioureas as recoverable and reusable catalysts for enantioselective nitro-Michael reactions." Beilstein Journal of Organic Chemistry 12 (April 1, 2016): 628–35. http://dx.doi.org/10.3762/bjoc.12.61.

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The catalytic activity of different supported bifunctional thioureas on sulfonylpolystyrene resins has been studied in the nitro-Michael addition of different nucleophiles to trans-β-nitrostyrene derivatives. The activity of the catalysts depends on the length of the tether linking the chiral thiourea to the polymer. The best results were obtained with the thiourea derived from (L)-valine and 1,6-hexanediamine. The catalysts can be used in only 2 mol % loading, and reused for at least four cycles in neat conditions. The ball milling promoted additions also worked very well.

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15

Chayah, Mariem, M. Encarnación Camacho, M. Dora Carrión, Miguel A. Gallo, Miguel Romero, and Juan Duarte. "N,N′-Disubstituted thiourea and urea derivatives: design, synthesis, docking studies and biological evaluation against nitric oxide synthase." MedChemComm 7, no. 4 (2016): 667–78. http://dx.doi.org/10.1039/c5md00477b.

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16

Habila, Tahir, Mebrouk Belghobsi, Mohamed-Zakaria Stiti, et al. "Synthesis and vasodilator activity of 3,4-dihydropyrimidin-2(1H)-ones bearing urea, thiourea, and sulfonylurea moieties." Canadian Journal of Chemistry 97, no. 1 (2019): 20–28. http://dx.doi.org/10.1139/cjc-2018-0239.

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A series of novel 3,4-dihydropyrimidin-2(1H)-ones bearing urea, thiourea, and sulfonylurea moieties were synthesized and pharmacologically evaluated as vasodilator agents. The most interesting vasodilators were the thiourea derivatives 6a and 6b and the urea derivatives 6f–6i and 7f–7h, although the ureas were relatively more active than thioureas. Twenty-fold more active than diazoxide, the urea 6g was the most potent vasodilator (EC50 = 0.983 ± 0.061 μmol/L) and proved to act as a voltage-gated calcium channel blocker. The lack of activity of sulfonylureas, 6k and 7j, could be attributed to

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17

Sun, Xueqi, Jingjing Zhang, Yuan Chen, et al. "Synthesis, Characterization, and the Antioxidant Activity of Carboxymethyl Chitosan Derivatives Containing Thiourea Salts." Polymers 11, no. 11 (2019): 1810. http://dx.doi.org/10.3390/polym11111810.

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A new class of chitosan derivatives possessing thiourea salts were synthesized to improve the solubility and the antioxidant activity of chitosan. Firstly, chitosan was modified to carboxymethyl chitosan, combining carboxymethyl chitosan with thiourea salts that have different structures to form new chitosan derivatives. The chitosan and chitosan derivatives were characterized by FT-IR, 13C NMR, TGA, and elemental analyses. The new peaks of thiourea salts could be clearly observed at about 1240 cm–1 in the IR spectra, and the peak of C=S was clearly observed at around 180 ppm in the 13C NMR. I

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18

Ramnathan, A., K. Sivakumar, K. Subramanian, N. Janarthanan, K. Ramadas, and H. K. Fun. "Symmetrically Substituted Thiourea Derivatives." Acta Crystallographica Section C Crystal Structure Communications 51, no. 11 (1995): 2446–50. http://dx.doi.org/10.1107/s010827019500607x.

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19

Drzewiecka-Antonik, Aleksandra, Marta Struga, Agnieszka Głogowska, et al. "Synthesis, Structural Characterization and Biological Activity Evaluation of Novel Cu(II) Complexes with 3-(trifluoromethyl)phenylthiourea Derivatives." International Journal of Molecular Sciences 23, no. 24 (2022): 15694. http://dx.doi.org/10.3390/ijms232415694.

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Copper complexes with 1,3-disubstituted thiourea derivatives, all containing 3-(trifluoromethyl)phenyl tail and 1-alkyl/halogen-phenyl substituent, were synthesized. The experimental spectroscopic studies and theoretical calculation revealed that two ligands coordinate to Cu(II) in a bidentate fashion via thiocarbonyl S and deprotonated N atoms of thiourea moiety. Such monomers are characteristic of alkylphenylthiourea complexes, whereas the formation of a sandwich-type dimer is observed for halogeno derivatives. For the first time, the structural identifications of CuN2S2-based complexes usin

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20

Nedeljkovic, Nikola, Vladimir Dobricic, Marina Mijajlovic, Zorica Vujic, and Milos Nikolic. "Molecular Docking Analysis of Novel Thiourea Derivatives of Naproxen with Potential Antitumor Activity." Experimental and Applied Biomedical Research (EABR) 24, no. 3 (2023): 235–42. http://dx.doi.org/10.2478/sjecr-2021-0037.

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Abstract Naproxen, as a propionic acid derivative, causes serious gastrointestinal side effects due to the presence of free carboxylic group. In that sense, masking of carboxylic group with other pharmacophores may be a promising strategy to decrease gastrointestinal toxicity. Thiourea derivatives have been intensively investigated as potential antitumor drugs, whereby their activity is based on potential inhibition of protein kinases, topoisomerases, carbonic anhydrase and sirtuins. In addition, it was shown that inhibition of certain protein kinases might reverse resistance to chemotherapeut

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21

Abd Halim, Ainaa Nadiah, and Zainab Ngaini. "Synthesis and Bacteriostatic Activities of Bis(thiourea) Derivatives with Variable Chain Length." Journal of Chemistry 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/2739832.

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A series of 1,4-bis(decoxyphenyl)carbamothioyl-terephthalamide derivatives was successfully synthesised by reaction of benzene-1,4-dicarbonyl isothiocyanate intermediates with long alkyl chain. The alkylation was performed via Williamson etherification of 4-acetamidophenol with bromoalkanes. The synthesised bis(thiourea) derivatives differed in the chain length, CnH2n+1, wheren=10, 12, and 14. The structures of all compounds were characterised by elemental CHN analysis, IR,1H, and13C NMR spectroscopies. Bacteriostatic activities of bis(thiourea derivatives which consisted of two folds of N-H,

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22

Nurkenov, O. A., S. D. Fazylov, T. M. Seilkhanov, Zh Nurmaganbetov, A. M. Gazaliev, and G. Zh Karipova. "Synthesis and structure of thiourea derivatives of functionally substituted pyridines." Bulletin of the Karaganda University. "Chemistry" series 101, no. 1 (2021): 4–11. http://dx.doi.org/10.31489/2021ch1/4-11.

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The article presents data on the synthesis and study of the structure of thiourea derivatives of functionally substituted pyridines. New thiourea derivatives containing a pharmacologically active pyridine moiety in their structure were obtained. As the starting synton, 2-amino-5-bromopyridine, 2-amino-3-hydroxypyridine and 2-aminomethylpyridine were selected. It was shown that the interaction of 2-amino-5-bromopyridine, 2-amino-3-hydroxypyridine and 2-aminomethylpyridine with ethyl and phenylisothiocyanates in ethanol leads to the formation of the corresponding pyridine-containing thioureas. T

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23

G., R. Dey. "Radical cations and radicals of thiourea and its derivatives in n-butyl chloride solutions: A pulse radiolysis study." Journal of Indian Chemical Society Vol. 97, No. 11a, Nov 2020 (2020): 2233–41. https://doi.org/10.5281/zenodo.5653500.

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Radiation and Photochemistry Division, Homi Bhabha National Institute, Bhabha Atomic Research Centre, Trombay, Mumbai-400 085, India <em>E-mail</em>: grdey@barc.gov.in <em>Manuscript received online 10 October 2020, revised and accepted 31 November 2020</em> The formation of radical cations and radicals of thiourea and its derivatives such as thiosemicarbazide, diethylthiourea, phenylthiourea in <em>n</em>-butyl chloride solutions using pulse radiolysis technique is reported. Solute radical cations generated initially produce respective radicals on deprotonation. The yields of radicals of thes

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24

Strzyga-Łach, Paulina, Alicja Chrzanowska, Katarzyna Podsadni, and Anna Bielenica. "Investigation of the Mechanisms of Cytotoxic Activity of 1,3-Disubstituted Thiourea Derivatives." Pharmaceuticals 14, no. 11 (2021): 1097. http://dx.doi.org/10.3390/ph14111097.

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Substituted thiourea derivatives possess confirmed cytotoxic activity towards cancer but also normal cells. To develop new selective antitumor agents, a series of 3-(trifluoromethyl)phenylthiourea analogs were synthesized, and their cytotoxicity was evaluated in vitro against the cell line panel. Compounds 1–5, 8, and 9 were highly cytotoxic against human colon (SW480, SW620) and prostate (PC3) cancer cells, and leukemia K-562 cell lines (IC50 ≤ 10 µM), with favorable selectivity over normal HaCaT cells. The derivatives exerted better growth inhibitory profiles towards selected tumor cells tha

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25

Gaber, Abd El-Aal M., Morsy M. Aly, and Ahmed A. Atalla. "Thermolysis of some thiourea derivatives." Collection of Czechoslovak Chemical Communications 56, no. 10 (1991): 2183–87. http://dx.doi.org/10.1135/cccc19912183.

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Thermolysis of N/benzoyl-N’,N’-diphenylthiourea (BDTU)(I) at 250°C gives NH3, H2S, H2O, benzaldehyde, benzil, benzonitrile, diphenylamine, diphenylcyanamide, 2-phenylbenzimidazole, benzoyl isothiocyanate, carbazole and 2-phenylbenzthiazole, whereas, thermolysis of N-benzoyl-N'-o-tolylthiourea (BTTU) (II) under the same conditions afford NH3, H2S, H2O, benzaldehyde, benzil, benzonitrile, o-toluidine, o-tolyl isothiocyanate, o-tolylcyanamide, benzoyl isothiocyanate and N,N’-di-o-tolylthiourea. The main feature of these thermolyses is homolysis of the amide and thioamide bonds providing free radi

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26

Mehandjiev, A., G. Vassilev, and P. Yonova. "Radioprotective Effect of Thiourea Derivatives." Biotechnology & Biotechnological Equipment 7, no. 2 (1993): 66–71. http://dx.doi.org/10.1080/13102818.1993.10818697.

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Ruswanto, Ruswanto, Richa Mardianingrum, Tita Nofianti, Anindita Tri Kusuma Pratita, Fahmi Muhamad Naser, and Siswandono Siswandono. "Design and computational study of the thiourea–cobalt(III) complex as an anticancer candidate." Journal of Pharmacy & Pharmacognosy Research 11, no. 3 (2023): 499–516. http://dx.doi.org/10.56499/jppres23.1622_11.3.499.

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Context: Cancer is a disease characterized by the formation of abnormal cells and uncontrollably. Over the past three decades, cobalt complexes' anticancer potential has been thoroughly investigated, and a lot of time has been spent figuring out how they work. In another study, the 1-Benzoyl-3-methylthiourea is one of the thiourea derivatives that have anticancer activity. The Modification of thiourea into a thiourea–cobalt(III) complex was carried out to increase the anticancer activity. Aims: To obtain a thiourea-cobalt(III) derivative compound that can be used as an anticancer breast candid

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28

Hritzová, Oľga, Peter Kutschy, Ján Imrich, and Thomas Schöffmann. "Hydrogen bonds in N-(3-chloro-2-benzo[b]thienocarbonyl)- and N-(2-benzo[b]thienocarbonyl)-N'-monosubstituted thioureas." Collection of Czechoslovak Chemical Communications 52, no. 11 (1987): 2673–79. http://dx.doi.org/10.1135/cccc19872673.

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N-(3-Chloro-2-benzo[b]thienocarbonyl)-N'-monosubstituted thiourea derivatives undergo photocyclizations with lower yields than those obtained from analogous N',N'-disubstituted derivatives. This decreased reactivity is caused by the existence of a six-membered cyclic form with the very strong hydrogen bond NH···O=C. The possibility of formation of various conformers has been found with N-(2-benzo[b]thienocarbonyl)-N'-monosubstituted thiourea derivatives as a consequence of the rotation around the C(2)-C(O) connecting line.

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29

Mistry, Bhupendra M., Han-Seung Shin, Muthuraman Pandurangan, and Rahul V. Patel. "Synthesis of Acyl Thiourea Derivatives of 7-Trifluoromethyl-2-Pyridylquinazolin-4(3H)-one as Anticancer Agents." Journal of Chemical Research 41, no. 10 (2017): 598–602. http://dx.doi.org/10.3184/174751917x15064232103074.

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A new series of 7-trifluoromethyl-2-pyridylquinazolin-4(3 H)-one-based acyl thiourea derivatives has been generated and tested for their cytotoxicity towards human ovarian cancer (SK-OV-3), cervical cancer (HeLa), renal cancer (Caki-2) cell lines, as well as noncancerous a human umbilical vein endothelial cell (HUVEC) line. The new thiourea derivatives were found to be promisingly cytotoxic towards the cancerous cell lines. Changing the substituent at the thiourea linkage led to variations in the cytotoxic potential of the resultant derivatives towards specific cell lines. Molecules with fluor

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30

Butina, Yuliya V., Elena A. Danilova, Maxim V. Dmitriev, and Aleksey V. Solomonov. "CRYSTAL STRUCTURE OF BIS[1-(DIAMINOMETHYLENE)-THIOURON-1-IUM] SULFATE." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 60, no. 1 (2017): 45. http://dx.doi.org/10.6060/tcct.2017601.5483.

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For citation:Butina Yu.V., Danilova E.A., Dmitriev M.V., Solomonov А.V. Crystal structure of bis[1-(diaminomethylene)-thiouron-1-ium] sulfate. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 1. P. 45-49. In this work crystal data of bis[1-(diaminomethylene)-thiouron-1-ium] sulfate is shown. This compound was characterized by IR spectroscopy and elemental analysis. The monocrystal of this compound was obtained and the structure was confirmed by single X-ray analysis. Moreover, the work describes potential application of synthesized compound. Comparative characteristics of thioure

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Jovanovic, Predrag, Milos Petkovic, Milena Simic, Branka Ivkovic, and Vladimir Savic. "A novel thiourea type organocatalyst possessing a single NH functionality." Organic & Biomolecular Chemistry 14, no. 28 (2016): 6712–19. http://dx.doi.org/10.1039/c6ob00387g.

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A novel thiourea organocatalyst was rationally designed by altering a typical H-bonding pattern of thiourea derivatives and utilising the potential of the 3,5-bis(trifluoromethyl)phenyl motif to participate in the H-bond formation.

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32

Shaw, Mukta, Yogesh Kumar, Rima Thakur, and Amit Kumar. "Electron-deficient pyridinium salts/thiourea cooperative catalyzed O-glycosylation via activation of O-glycosyl trichloroacetimidate donors." Beilstein Journal of Organic Chemistry 13 (November 9, 2017): 2385–95. http://dx.doi.org/10.3762/bjoc.13.236.

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The glycosylation of O-glycosyl trichloroacetimidate donors using a synergistic catalytic system of electron-deficient pyridinium salts/aryl thiourea derivatives at room temperature is demonstrated. The acidity of the adduct formed by the 1,2-addition of alcohol to the electron-deficient pyridinium salt is increased in the presence of an aryl thiourea derivative as an hydrogen-bonding cocatalyst. This transformation occurs under mild reaction conditions with a wide range of O-glycosyl trichloroacetimidate donors and glycosyl acceptors to afford the corresponding O-glycosides in moderate to goo

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33

Ruswanto, Ruswanto, Richa Mardianingrum, and Arry Yanuar. "Computational Studies of Thiourea Derivatives as Anticancer Candidates through Inhibition of Sirtuin-1 (SIRT1)." Jurnal Kimia Sains dan Aplikasi 25, no. 3 (2022): 87–96. http://dx.doi.org/10.14710/jksa.25.3.87-96.

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Cancer is a disease that starts from the uncontrolled growth of abnormal cells in the organs or tissues of the body, which is the second leading cause of death in the world. One of the targets in discovering and developing anticancer drugs is Sirtuin-1. SIRT1 can act as a tumor suppressor or tumor promoter depending on its target in a particular signalling pathway or on particular cancer. This study aimed to study the interaction of a thiourea derivative with SIRT1 (PDB ID:4I5I) through its inhibition of histone deacetylase. Research has been carried out in silico with molecular docking (MGLTo

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34

Dr., S. P. Rathod, and P. Mitake A. "A Research Review on the Synthesis of Thiourea Dioxide and Its Derivatives." International Journal of Advance and Applied Research S6, no. 18 (2025): 667–69. https://doi.org/10.5281/zenodo.15260845.

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<em>Thiourea dioxide (TUD) is a highly reactive sulphur-containing compound known for its various applications, particularly as a reducing agent in organic chemistry. Due to its unique reactivity towards different substrates, TUD has been used as a starting material for synthesizing derivatives that exhibit a range of chemical and biological activities. This paper provides an overview of the synthesis of thiourea dioxide and its derivatives, their chemical properties, and their potential industrial and pharmaceutical uses.</em>

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35

Rekia Nabti, Rekia Nabti, Nasser Belboukhari Nasser Belboukhari, Khaled Sekkoum Khaled Sekkoum, Noureddine Boulenouar Noureddine Boulenouar, and Houssem Boulebd and Salah Akkal Houssem Boulebd and Salah Akkal. "Synthesis, Characterization, DFT Calculations and Anticoagulant Activity of Symmetrical and Unsymmetrical N-Aryl Thiourea Derivatives." Journal of the chemical society of pakistan 46, no. 1 (2024): 81. http://dx.doi.org/10.52568/001420/46.01.2024.

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The present study reports a methodology for the synthesis of symmetrical and unsymmetrical thiourea derivatives 1-9, which have been prepared in good overall yields from condensation reactions between phenylisothiocyanate and different primary amines. The structures of all products were confirmed by the spectroscopic analysis (UV, IR, and NMR). These derivatives were tested for anticoagulant activity using PT and APTT reagents, and those reagents are considered also a controller, the results showed that the theN-aryl thiourea derivatives have very high anticoagulant activity. Theoretical calcu

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Schroeder, Zachary W., L. K. Hiscock, and Louise Nicole Dawe. "Copper(II)- and gold(III)-mediated cyclization of a thiourea to a substituted 2-aminobenzothiazole." Acta Crystallographica Section C Structural Chemistry 73, no. 11 (2017): 905–10. http://dx.doi.org/10.1107/s205322961701381x.

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Benzothiazole derivatives are a class of privileged molecules due to their biological activity and pharmaceutical applications. One route to these molecules is via intramolecular cyclization of thioureas to form substituted 2-aminobenzothiazoles, but this often requires harsh conditions or employs expensive metal catalysts. Herein, the copper(II)- and gold(III)-mediated cyclizations of thioureas to substituted 2-aminobenzothiazoles are reported. The single-crystal X-ray structures of the thiourea N-(3-methoxyphenyl)-N′-(pyridin-2-yl)thiourea, C13H13N3OS, and the intermediate metal complexes aq

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37

Agili, Fatimah A. "Biological Applications of Thiourea Derivatives: Detailed Review." Chemistry 6, no. 3 (2024): 435–68. http://dx.doi.org/10.3390/chemistry6030025.

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Thiourea and its derivatives have become a significant focal point within the organic synthesis field, garnering attention for their diverse biological applications, including antibacterial, antioxidant, anticancer, anti-inflammatory, anti-Alzheimer, antituberculosis and antimalarial properties. My objective is to present a comprehensive and easily understandable analysis of recent advancements in the organic synthesis of thiourea derivatives. My focus is on the structure and activity of these derivatives over the past five years, highlighting the significant progress made in the field of orga

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Sukdolak, S., N. Vukovic, S. Solujic, M. Milosev, N. Manojlovic, and Lj Krstic. "Synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives." Journal of the Serbian Chemical Society 71, no. 6 (2006): 581–85. http://dx.doi.org/10.2298/jsc0606581s.

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Aminothiazole derivatives of 4-hydroxy-2H-chromen-2-one were prepared by the Hantzsch reaction1 using 3-(2-bromoacetyl)-4-hydroxy-2H-chromen-2-one and thiourea derivatives. Starting compound for this synthesis 3-(2-bromoacetyl)-4-hydroxy- 2H-chromen-2-one (1) was prepared previously.2 Also, for this synthesis we used thiourea derivatives (2a-j) as compounds which possess groups with biological activity. Reactions are carried out in refluxing ethanol for a period of 30 - 45 min. Final products (3a-j) are obtained in a high yield. Chemical structure of the obtained compounds was confirmed by ele

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Tiwari, Ram Prakash, Krishna Srivastava, Abhishek Srivastava, Shailesh Kumar Mishra, and Amit Tripathi. "Synthesis and Biological evalution of heterocyclic oxazine-2-carbonothioyl)quinazolin-4(3H)-one and oxazine-2(3H)-carbothioamide derivatives." Research Journal of Chemistry and Environment 27, no. 11 (2023): 60–71. http://dx.doi.org/10.25303/2711rjce060071.

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An efficient route for the preparation of novel heterocyclic oxazine-carbonothioyl-quinazolin-(3H)-one and oxazine-(3H)-carbothioamide derivatives is through synthesis of 2-phenyl-4H-benzo[d][1,3] oxazin-4-one(anthranilic acid and benzoyl chlordide) which further reacts with thiourea and thiosemicarbazide to give substituted amines, which formed oxo-2-phenylquinazoline-3(4H)-carbothioa mide and oxo-2-phenylquinazolin-3(4H)-yl)thiourea (β-naphthol,substituted aromatic formedehyde). The structures of all the prepared derivatives were elucidated by using UV-Vis IR, 1HNMR and Mass spectral studies

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40

Ohl, Coralie, Estelle Thetiot, Laurence Charles, Yohann Catel, Pascal Fässler, and Jacques Lalevée. "Evaluation of Various Thiourea Derivatives as Reducing Agents in Two-Component Methacrylate-Based Materials." Polymers 17, no. 15 (2025): 2017. https://doi.org/10.3390/polym17152017.

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Two-component dental materials are commonly used by the dentist for various applications (cementation of indirect restorations, filling of a cavity without layering, etc.). These materials are cured by redox polymerization. The (hydro)peroxide/thiourea/copper salt redox initiator system is well established and can be found in a wide range of commercially available dental materials. The thiourea is a key component of the initiator system. This study explores the influence of the nature of the thiourea reducing agent on the reactivity and efficiency of redox initiator systems. In this work, six

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Gackowski, Marcin, Mateusz Jędrzejewski, Sri Satya Medicharla, et al. "Novel Thiourea and Oxime Ether Isosteviol-Based Anticoagulants: MD Simulation and ADMET Prediction." Pharmaceuticals 17, no. 2 (2024): 163. http://dx.doi.org/10.3390/ph17020163.

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Activated blood coagulation factor X (FXa) plays a critical initiation step of the blood-coagulation pathway and is considered a desirable target for anticoagulant drug development. It is reversibly inhibited by nonvitamin K antagonist oral anticoagulants (NOACs) such as apixaban, betrixaban, edoxaban, and rivaroxaban. Thrombosis is extremely common and is one of the leading causes of death in developed countries. In previous studies, novel thiourea and oxime ether isosteviol derivatives as FXa inhibitors were designed through a combination of QSAR studies and molecular docking. In the present

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Siddiqui, Hina, Sarah Shafi, Farah Mukhtar, Asma Ejaz, Atta ur-Rahman, and M. Iqbal Choudhary. "Inhibition of Adipogenesis by Thiourea Derivatives." Medicinal Chemistry 14, no. 5 (2018): 508–15. http://dx.doi.org/10.2174/1573406413666171120161208.

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Sudzhaev, A. R., I. A. Rzaeva, R. A. Nadzhafova, Yu S. Safarov, and M. A. Allakhverdiev. "Antioxidant properties of some thiourea derivatives." Russian Journal of Applied Chemistry 84, no. 8 (2011): 1394–97. http://dx.doi.org/10.1134/s1070427211080167.

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44

Bhattacharyya, Pravat, Alexandra M. Z. Slawin, Martin B. Smith, David J. Williams, and J. Derek Woollins. "Diphosphine derivatives of urea and thiourea." Journal of the Chemical Society, Dalton Transactions, no. 18 (1996): 3647. http://dx.doi.org/10.1039/dt9960003647.

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45

Madarász, Ádám, Zsolt Dósa, Szilárd Varga, Tibor Soós, Antal Csámpai, and Imre Pápai. "Thiourea Derivatives as Brønsted Acid Organocatalysts." ACS Catalysis 6, no. 7 (2016): 4379–87. http://dx.doi.org/10.1021/acscatal.6b00618.

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46

Leblond, Jeanne, Nathalie Mignet, Céline Largeau, Johanne Seguin, Daniel Scherman, and Jean Herscovici. "Lipopolythiourea Transfecting Agents: Lysine Thiourea Derivatives." Bioconjugate Chemistry 19, no. 1 (2008): 306–14. http://dx.doi.org/10.1021/bc7001924.

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47

Succaw, Gary L., Timothy J. R. Weakley, Fusan Han, and Kenneth M. Doxsee. "Crystal Engineering with Bis(thiourea) Derivatives†." Crystal Growth & Design 5, no. 6 (2005): 2288–98. http://dx.doi.org/10.1021/cg050162c.

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48

Rosiak, Damian, Andrzej Okuniewski, and Jarosław Chojnacki. "Copper(I) iodide ribbons coordinated with thiourea derivatives." Acta Crystallographica Section C Structural Chemistry 74, no. 12 (2018): 1650–55. http://dx.doi.org/10.1107/s2053229618015620.

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Two products of the reactions of CuI with 1-benzoyl-3-(4-bromophenyl)thiourea and with 1-benzoyl-3-(2-iodophenyl)thiourea have been obtained and characterized, namely poly[[[1-benzoyl-3-(4-bromophenyl)thiourea-κS]-μ3-iodido-copper(I)] acetone hemisolvate], {[CuI(C14H11BrN2OS)]·0.5C3H6O} n , and poly[μ4-iodido-μ3-iodido-[N-(benzo[d]thiazol-2-yl)benzamide-κN]dicopper(I)], [Cu2I2(C14H10N2OS)] n . Their structures, determined by single-crystal X-ray diffraction analysis, exhibit different stoichiometries and molecular organizations; however, both compounds are polymeric and possess close Cu...Cu c

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Safin, Damir A., Maria G. Babashkina, Koen Robeyns, Michael Bolte, and Yann Garcia. "N-Salicylidene aniline derivatives based on the N′-thiophosphorylated thiourea scaffold." CrystEngComm 16, no. 30 (2014): 7053–61. http://dx.doi.org/10.1039/c4ce00598h.

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A new family of thermochromic N′-thiophosphorylated thiourea-containing N-salicylidene aniline derivatives (anils) of the common formula 6-{(2-OH-aryl)–CHN}-Py-2-NHC(S)NHP(S)(OiPr)<sub>2</sub> has been synthesized by the condensation of N-thiophosphorylated thiourea 6-NH<sub>2</sub>-Py-2-NHC(S)NHP(S)(OiPr)<sub>2</sub> with the corresponding salicylaldehyde.

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50

Semwal, Amit, Amit Nigam, and D. C. P. Singh. "Synthesis, Characterization and Biological Activity of Novel N-p-methylbenzoyl-N’ substituted thiourea." International Journal of Drug Design and Discovery 2, no. 4 (2011): 654–58. https://doi.org/10.37285/ijddd.2.4.7.

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A series of N-p-methylbenzoyl-N’ thiourea derivatives bearing different substituents have been synthesized and screened in order to evaluate for their antibacterial and antifungal activity. Antibacterial and antifungal activity of the title compounds has been evaluated by varying the substituents in the thiourea moiety. Reaction of p-methylbenzoyl chloride with ammonium thiocynate followed by the addition of various aromatic amines afforded N-p-methylbenzoyl-N’ substituted thiourea. The structures of newly synthesized compounds has been supported by IR and 1HNMR spectral analysis. Among the sy

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