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Dissertations / Theses on the topic 'THP-1 human macrophages'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Ackermann, Kathrin [Verfasser], and Ralf [Akademischer Betreuer] Kinscherf. "Atherosclerosis: The Role of Growth-Differentiation-Factor-15 (GDF-15) in human THP-1 Macrophages Autophagy and Lipid homeostasis / Kathrin Ackermann ; Betreuer: Ralf Kinscherf." Marburg : Philipps-Universität Marburg, 2020. http://d-nb.info/1218685832/34.

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2

Hoppmann, Susan. "18F-markierte S100-Proteine als potentielle Radioliganden für die funktionelle Charakterisierung des Rezeptors für advanced glycation endproducts (RAGE) in vitro und in vivo." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-24725.

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Die Interaktion von S100-Proteinen mit dem Rezeptor für advanced glycation endproducts (RAGE) wird als hoch relevant bei der Entstehung, Manifestation und Progression verschiedener entzündlicher Erkrankungen sowie bei der Tumorigenese gewertet. Das tiefergehende Verständnis der Interaktion von S100-Proteinen mit RAGE in vivo stellt eine wissenschaftliche Herausforderung dar und ist ein Ansatz für therapeutische Interventionen. Darüber hinaus stellen Untersuchungen zum Metabolismus von extrazellulär zirkulierenden S100-Proteinen in vivo einen vielversprechenden Forschungsansatz zur Analyse von

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3

Chang, Eddie. "The role of perforin and chemokines in the pathogenesis of chronic corneal inflammation induced by herpes simplex virus type-1 infection." free to MU Campus, others may purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091911.

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4

Goswami, T. "A study of the murine and human homologues of the natural resistance associated macrophage protein 1." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599542.

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To investigate the possibility that apoptotic cell death is a mechanism by which Nramp1 mediates resistance to macrophage infection, the influence of Nramp1 on cellular apoptosis was studied by DNA fragmentation analyses using the Nramp1<SUP>WT</SUP> and Nramp1<SUP>M</SUP> macrophage cell lines. It was observed that basal levels of apoptosis were higher in Nramp1<SUP>WT</SUP> cells than Nramp1<SUP>M</SUP> macrophages. The effect of activation with LPS and/or IFNγ on apoptosis appeared to be Nramp1-independent. Experiments with the iNOS specific inhibitor, SMT, and the NO donor, sodium nitropru

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5

Gomez, Alejandro Martin. "Study of the HIV-1-mediated induction of BAFF in primary human monocytes and monocyte-derived macrophages." Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26298.

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L’infection par le VIH-1 (Virus de l’Immunodéficience Humaine de type I) est caractérisée par une réplication virale persistante, une activation chronique du système immunitaire, une déplétion des cellules T CD4+ et de plusieurs dysfonctionnements immunitaires qui sont observés même chez les cellules qui ne sont pas ciblées par le virus telles que les cellules B. Plusieurs cytokines et facteurs de croissance, qui sont augmentées dans le sérum des individus infectés par le VIH-1, ont été suggérés de déclencher directement et/ou indirectement l'activation des cellules B, et l'un d'eux est BAFF (

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6

Liu, Li. "The regulation of interferon regulatory factor-1 in raw 264.7 murine macrophages and human umbilical vein endolethial cells." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248271.

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7

Shinoe, Takashi. "The pro-apoptotic human BH3-only peptide harakiri is expressed in Cryptococcus-infected perivascular macrophages in HIV-1 encephalitis patients." Kyoto University, 2011. http://hdl.handle.net/2433/142106.

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8

Lê-Bury, Gabrielle. "Infection des macrophages par le VIH-1 : facteurs moléculaires impliqués dans la production virale et dans le développement de bactéries opportunistes The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking Pronounced stealth phenotype and differential pyroptosis induction by invasive Salmonella Typhimurium revealed by coinfection of human macrophages with HIV Role of Solute Carriers in efficient HIV-1 production by human macrophages." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB094.

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Le Virus de l'Immunodéficience Humaine de type 1 (VIH-1) infecte les macrophages. Contrairement aux lymphocytes T CD4+, les macrophages résistent aux effets cytotoxiques du virus et représentent un réservoir pour ce pathogène. Dans ces cellules, le virus est produit et stocké dans un compartiment intracellulaire spécifique appelé VCC (Virus-Containing Compartment). Ce compartiment à pH neutre, transitoirement connecté à la membrane plasmique, reste cependant très peu caractérisé. Par ailleurs, le VIH-1 induit une perturbation des fonctions des macrophages, permettant ainsi le développement de

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9

Mikhailova, Anastassia. "AAC-11 derived peptides antagonize the survival and infection of HIV-1 susceptible CD4+T cells and macrophages." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC329.

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Malgré plus de 30 ans de recherche intensive depuis le début de l’épidémie, le virus de l’immunodéficience humaine (VIH) reste l’un des plus gros problème de santé publique. L’une des problématiques les plus importantes empêchant le progrès vers la résolution de combat avec cette maladie reste de comprendre comment le VIH de type 1 établie l’infection et la persistance dans ses réservoirs. Et ce, malgré l’effet cytotoxique du virus qui est observé in vitro et in vivo. Ce travail montre que le VIH-1 dépend de la voie de signalisation anti-apoptotique d’AAC-11 pour établir l’infection dans les l

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10

Reimer, Thornik. "Infection of human macrophages with cytosolic "Listeria monocytogenes" is associated with an interferon-beta response in the apparent absence of interferon-regulatory factor-3 and interferon-regulatory factor-1 activation /." Bern : [s.n.], 2006. http://www.stub.ch/index.php?p=1&i=645.

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11

Mahmood, Dler Faieeq Darweesh. "Thioredoxin-1 (Trx1) : a new target in the treatment of cardiovascular diseases." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2014. http://tel.archives-ouvertes.fr/tel-01069096.

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The cardiovascular diseases (CVDs), resulting from complications of atherosclerosis, remain the leading cause of morbidity and death worldwide. Atherosclerosis as a chronic inflammatory disease, involves both innate and adaptive arms of immunity in which macrophages play the orchestral role in modulating lesion initiation, progression, and potentially devastating thrombotic complications. Available evidences support the notion of a central role of oxidative stress, due mainly to the imbalance between antioxidants and reactive oxygen species (ROS) in CVDs. Furthermore, the pathology is frequent

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12

Papargyris, Loukas. "Mécanismes de génération des macrophages immunorégulateurs humains : rôle de l’axe IL-27 / Adénosine / PGE2 The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27 Faecalibacterium prausnitzii Skews Human DC to Prime IL10-Producing T Cells Through TLR2/6/JNK Signaling and IL-10, IL-27, CD39, and IDO-1 Induction." Thesis, Angers, 2019. http://www.theses.fr/2019ANGE0038.

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Ce projet de thèse s’inscrit dans l’étude des mécanismes moléculaires associés à la polarisation des macrophages humains vers un phénotype immunorégulateur similaire à celui des macrophages tumoraux (TAM). Des données du laboratoire avaient montré le rôle de l'IL-27 dans ce processus, notamment au travers de sa capacité à moduler l'expression de CD39 qui contrôle, au moins en partie, l’acquisition d’un phénotype immunorégulateur par les macrophages humains. L’objectif de ce travail a été de préciser les mécanismes moléculaires impliqués dans l’acquisition du phénotype régulateur, en aval de l’

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13

Konarski, Yulia. "SHP-1/ Src Complex is a Master Regulator of the IL-12/IL-23 pro- and IL-10/IL-27 Anti-inflammatory Axis in TLR4-activated Signaling Pathways in Human Monocytes and Macrophages." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/25999.

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Although the etiology surrounding many autoimmune diseases remains unknown, the underlying characteristic of many of these diseases is a disruption in the balance of pro- and anti- inflammatory cytokines It is well established that the dysregulation of the IL-12 family of cytokines, an increase in IL-12/IL-23 and a decrease in IL-27 production has been implicated in these conditions. We used ELISA, RT-PCR, Immunofluorescence and Western immunoblotting in conjunction with pharmalogical inhibitors and siRNA to demonstrate the role of SHP-1/Src in the regulation of IL-12, IL-23, IL-27 and IL-10 i

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14

Richards, Kathryn H. "Mutations in the vpu and env Genes of HIV-1 Can Adversely Impact Infectivity: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/378.

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The Human Immunodeficiency Virus (HIV) is able to infect CD4+ T cells as well as macrophages. Macrophage-tropism has been linked to determinants in the envelope of HIV. These determinants allow envelopes to exploit low levels of CD4 for infection. Macrophages are an important reservoir of virus, especially during chronic infection, and are likely responsible for the bulk of virus produced after CD4+T cells have declined. Viral factors that may impact the ability to infect macrophages are worth studying because this cell type is so important in infection. It was previously reported that the mac

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15

Mendes, Luís Filipe Figueiredo. "Metabolomics study of flavonoid-induced metabolic reprogramming in human macrophages." Master's thesis, 2018. http://hdl.handle.net/10773/25305.

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The ability of macrophages to change between pro-inflammatory (M1-like) and anti-inflammatory (M2-like) phenotypes makes their modulation an attractive therapeutic strategy to mitigate excessive and/or chronic inflammation. Bioflavonoids are natural compounds with well documented anti-inflammatory activity. However, little is known about their molecular and metabolic effects on human macrophages. In this thesis, NMR metabolomics has been used to assess how different bioflavonoids (Quercetin, Naringenin and Naringin) modulate the metabolism of human macrophages, with a view to better understand

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16

Horvátová, Alžbeta. "Anti-inflammatory effects of ursodeoxycholyl lysophosphatidylethanolamide on THP-1 human macrophages via Toll-like receptor 4." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-351489.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Alžbeta Horvátová Supervisor: prof. PharmDr. Petr Pávek PhD. Title of diploma thesis: Anti-inflammatory effects of ursodeoxycholyl lysophosphatidylethanolamide on THP-1 human macrophages via Toll-like receptor 4 Nonalcoholic steatohepatitis (NASH) became the most common liver disease in developed countries. It is well-known that the level of protectant phosphatidylcholine (PC) is decreased in NASH. The bile acid-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide

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17

Chen, Chun-Ting, and 陳俊廷. "Dissecting the roles of TREM-1 and TREM-2 in the human macrophage cell line THP-1." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/hgm7cy.

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碩士<br>國立陽明大學<br>微生物及免疫學研究所<br>105<br>Triggering receptor expressed on myeloid cells (TREM), is a new family of surface receptors belongs to immunoglobulin like superfamily. TREM-1 and TREM-2 are two subtypes in TREM family. Both TREM-1 and TREM-2 express on monocyte-macrophage lineage and involve in diversity of immune response. TREM-1 can amplify inflammatory response by synergizing with toll-like receptor (TLR), and TREM-2 displays an anti-inflammatory regulator. However, current evidences regarding the roles of TREM-1 and TREM-2 on macrophage are mainly investigated by the studies in mouse

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18

Weng, Chang Ching, and 翁彰璟. "Mechanism of Salmonella-induced apoptosis in human macrophage-like THP-1 cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/25818682764285483368.

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碩士<br>長庚大學<br>生物醫學研究所<br>98<br>Salmonella is Gram-negative enterobacteria; it’s also a kind of facultative intracellular pathogen, which infection could cause different types of cell death, such as autophagy, necrosis, pyroptosis and apoptosis. There are two different type three secretion systems (TTSS) encoded by Salmonella pathogenicity islands I and II (SPI-1 & SPI-2). The SPI-1 TTSS is reported to control Salmonella invasion while SPI-2 TTSS contributes to Salmonella intracellular survival. In this study, we pretreated THP-1 cell with phagocytosis inhibitor (LY294002) and used the SPI-1 TT

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19

Baqui, A. A. M. Abdullahel. "Characterization of the response of GM-CSF supplemented THP-1 human monocytes to LPS of oral microorganisms." 1996. http://catalog.hathitrust.org/api/volumes/oclc/47363636.html.

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20

李姿儀. "Bactericidal effect and induction of IL-12 and IL-10 in human macrophage-like cells, THP-1, infected by Klebsiella pneumoniae or Salmonella enterica serovar typhimurium." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/82172345676571403718.

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碩士<br>長庚大學<br>基礎醫學研究所<br>92<br>Klebsiella pneumoniae is regarded as an opportunistic pathogen and a significant cause of nosocomial infections worldwide. In Taiwan, frequently, K. pneumoniae causes abscess in the internal organ such as the liver, mostly in diabetes, and clinical observations often suggest that some of K. pneumoniae strains might be true pathogens. We, therefore, undertook investigation on virulence factors that might be involved in K. pneumoniae pathogenesis. In search of virulence factors such as immune responses, like cytokine production, we mixed THP-1 cells, a h

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