Journal articles: 'Thread injection'

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Yang, Yang, Xin Zhang, and Hong Feng Zhang. "Design of Injection Mould with Thread Automatic Demoulding Mechanism for Focusing Handwheel." Advanced Materials Research 557-559 (July 2012): 1340–43. http://dx.doi.org/10.4028/www.scientific.net/amr.557-559.1340.

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According to the characteristics of threaded plastics in the focusing handwheel of the light machine, a kind of new type injection mould is designed to take off thread. The mould core consists of six flaps and a guide posts, and the whorl is taken off automatically through the relative motion by guide posts and flap. The injection mould effectively avoids the interference effect in the course of taking off thread. The productivity is increased effectively, and the stable plastics quality is kept in practical application.

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Molina, Gustavo Otoboni, Joze Fabiana Garcia Molina, Sheila Soratto Zeferino Nandi, and Eduarda Braz. "DESCRIPTION OF CUSTOM THREAD IGM TECHNIQUE WITH USE OF PDO FACIAL SUPPORT THREADS IN THE OROFACIAL HARMONIZATION." Journal of Research in Dentistry 9, no. 2 (December 20, 2021): 10. http://dx.doi.org/10.19177/jrd.v9e2202110-17.

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The aim of this article was to describe a thread lifting procedure used for face lifting and skin rejuvenation, developed by the Doctor Molina Dental Institute (IGM, in the Portuguese acronym), termed “IGM custom thread technique” that has shown excellent results in facial tissue repositioning for facial harmonization. In this study, rather than presenting the results, we have described and discussed the proposed custom thread injection technique.

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Jeong, Tae Kwang, Chang Ho Chung, and Kyung Hee Min. "Multi-modal treatment strategy for achieving an aesthetic lower face." Archives of Plastic Surgery 47, no. 3 (May 15, 2020): 256–62. http://dx.doi.org/10.5999/aps.2019.01830.

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Background Most women consider an oval-shaped face to be youthful and beautiful. In recent years, demand has grown for surgical procedures with a shorter downtime and fewer complications. These minimally invasive procedures include botulinum toxin type A (BoNTA) injection, filler injection, suction-assisted liposuction (SAL), laser-assisted lipolysis (LAL), thread lifting, and fat grafting. This study aims to introduce an effective method for creating an aesthetically pleasing lower face using a combination of minimally invasive procedures.Methods From March 2017 to March 2019, 94 patients simultaneously underwent LAL, SAL, and thread lifting. Ancillary procedures such as BoNTA injections, hyaluronic acid filler injections, and removal of the buccal fat pad (BFP) were selectively performed according to the patient’s condition.Results Patients rated their postoperative satisfaction as very satisfied, satisfied, dissatisfied, or very dissatisfied. Approximately 83% of all respondents were satisfied with the results, whereas the remaining respondents had complaints regarding the outcomes. The most common reasons for dissatisfaction were a longer-than-expected recovery time and undercorrection, and the most severe complaint was skin depression as a result of overcorrection.Conclusions Our method of simultaneously performing LAL, SAL, and thread lifting, while adding BoNTA, filler injections, and BFP removal as needed, was capable of producing consistent and reliable aesthetic outcomes for the lower face.

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Peng, Jui-Hui, and Peter Hsien-Li Peng. "HA Filler Injection and Skin Quality–Literature Minireview and Injection Techniques." Indian Journal of Plastic Surgery 53, no. 02 (August 2020): 198–206. http://dx.doi.org/10.1055/s-0040-1715545.

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AbstractAging of the face produces many changes in the structure and integrity of the skin and other anatomical aspects, the three major signs of which are volume loss, sagginess, and skin quality change. Through surgical or nonsurgical procedures, it is possible to slow or even reverse these mechanisms through artificial means, including thread lifting, radiofrequency, or filler injection. Filler injections are particularly popular in recent years, owing to their convenience, efficacy, and long-lasting results. In this minireview, the author outlines the basic mechanisms behind facial aging, discusses current literature on each aspect of facial aging, and offers injection protocol recommendations based on past literature and clinical experience.

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Park, Sang-LL, Seung-Jae Lee, Geuk-Sang You, and Jung-Chun Suh. "An Experimental Study on Tip Vortex Cavitation Suppression in a Marine Propeller." Journal of Ship Research 58, no. 03 (September 1, 2014): 157–67. http://dx.doi.org/10.5957/jsr.2014.58.3.157.

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Normally, tip vortex cavitation (TVC) is first observed at a certain location behind the tips of propeller blades. Therefore, TVC is important for naval ships and research vessels that require raising the cavitation inception speed to maximum possible values. The concepts for alleviating the tip vortex are summarized by Platzer and Souders (1979), who carried out a thorough literature survey. Active control of TVC involves the injection of a polymer or water from the blade tip. The main effect of such mass injection (both water and polymer solutions) into the vortex core is an increase in the core radius, consequently delaying TVC inception. However, the location of the injection port needs to be selected with great care to ensure that the mass injection is effective in delaying TVC inception. In the present study, we propose a semi-active control scheme that is achieved by attaching a thread at the propeller tip. The main idea of a semi-active control is that because of its flexibility, the attached thread can be sucked into the low-pressure region closer to the vortex core center. An experimental study using a scale model was carried out in the cavitation tunnel at the Seoul National University. It was found that a flexible thread can effectively suppress the occurrence of TVC under the design condition for a model propeller.

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Toy, Ç., Y. Palaci, and T. Baykara. "A new ceramic thread-guide composition via low-pressure injection molding." Journal of Materials Processing Technology 51, no. 1-4 (April 1995): 211–22. http://dx.doi.org/10.1016/0924-0136(94)01607-3.

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Wang, Jian-Jun, Xiao-Feng Sui, Shan-Po Jia, Zhong-Zhi Hua, and Si-Yao Wang. "Experimental Study on Sealing Failure Mechanism of Injection-Production String in Underground Gas Storage under Cyclic Loading." Advances in Materials Science and Engineering 2022 (August 25, 2022): 1–14. http://dx.doi.org/10.1155/2022/5206149.

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In order to clarify the impact of cyclic loading on the mechanical properties and sealing performance of threaded connections on pipe string under the injection-production conditions of gas storage and the airtight threaded connections suitable for the actual working conditions can be preferred, the sealing failure of injection and production tubular strings of several domestic gas storages was investigated comprehensively. It was found that the airtight threaded connections with different performance may leak during the service of tubular strings. Existing standards and testing methods have limitations, which are not fully applicable to the working environment of gas storage wells and the production mode of forced injection-production and cannot reflect the operation characteristics of multiround injection and production. Based on the stress analysis of the tubular string during injection and production, a full-scale simulation testing of 30 cycles of gas seal cycle under alternating load was proposed. The cyclic loading test results of two P110·13Cr tubing in domestic gas storage showed that after 30 cycles of cyclic loading, the yield strength, internal pressure strength, collapse strength, and compressive bearing capacity of tubing were all decreased; the compression efficiency of the joints should be fully considered when selecting the gas-sealed thread.

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Walton, A. G., J. Labadin, and S. P. Yiiong. "Axial Flow Between Sliding, Non-Concentric Cylinders with Applications to Thread Injection." Quarterly Journal of Mechanics and Applied Mathematics 63, no. 3 (May 19, 2010): 315–34. http://dx.doi.org/10.1093/qjmam/hbq009.

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Zhang, Yong Qiang, and Hai Bi. "Research on Machine-Code Level Injection and HOOK Technique." Advanced Materials Research 159 (December 2010): 424–28. http://dx.doi.org/10.4028/www.scientific.net/amr.159.424.

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HOOK and injection are advanced programming techniques. The common windows injection and HOOK techniques are introduced and analyzed in this paper. (1) By using hooks; (2) By using registration table;（3）By Trojan Horse DLL; (4) By PE import table; (5) By using remote thread. Proposed a method of non-DLL and gives a machine code-level implementations of the technology. Finally the paper lists the key technology and gives the main code.

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Carvalho, Rayan Marcel, Valdir Souza Ferreira, and Bruno Gabriel Lucca. "A novel all-3D-printed thread-based microfluidic device with an embedded electrochemical detector: first application in environmental analysis of nitrite." Analytical Methods 13, no. 11 (2021): 1349–57. http://dx.doi.org/10.1039/d1ay00070e.

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A fully 3D-printed microfluidic thread-based device containing an embedded electrochemical detector is first reported. A green method based on microflow injection analysis for sensing of nitrite ions in environmental samples is also first presented.

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Yang, Yuer, Zeguang Chen, Shaobo Chen, Zhuoyun Du, Yuxin Luo, Liangtian Zhao, Lifeng Zhou, and Yujuan Quan. "Avpd: An Anti-virus Model with Remote Thread Injection for Android Based on ResNet50." Journal of Physics: Conference Series 2203, no. 1 (March 1, 2022): 012078. http://dx.doi.org/10.1088/1742-6596/2203/1/012078.

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Abstract Most Android mobile anti-virus software in the industry is checked at the application level, and users familiar with the Android operating system are well aware that the use of virtual clicks, function execution, or shell commands can force the application to stop, which poses a threat to the real-time monitoring of anti-virus software. Moreover, the current mainstream anti-virus software in the industry can only let users manually uninstall or deactivate malicious apps when detected, which also makes the anti-virus software in Android mobile lose the ability of mobile anti-virus software to remove or delete viruses and Trojans automatically. To solve the problems above, in this paper, we train a mobile anti-virus model based on Resnet50 and proposes an Android mobile anti-virus method using remote thread injection - overriding the execution of malicious code by RTI means such as hook API, nulling related functions, rewriting related classes or functions to preserve the app as much as possible. In contrast, The model can identify malicious code with the highest accuracy. The model's recognition accuracy is up to 98.14%, and the malicious code blocking rate is up to 99.70% after recognition.

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Aziz, Makera, and Dena Ahmed. "Proposed Method to Prevent SQL Injection Attack." Iraqi Journal for Computers and Informatics 42, no. 1 (December 31, 2016): 59–63. http://dx.doi.org/10.25195/ijci.v42i1.85.

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the internet and its websites have huge using these days. These webs may have sensitive and secret information likemilitary information, financial information and other important information that transfer through the networks.Only some people have the authorization to see and access this information. So information has to transfer in secretenvironment. SQL injection represents one of the most important things that thread these webs. In which unauthorizedpeople can access to the data and information. This paper introduces a method that can be used to prevent SQL injectionby converting the user input to static string, use this string as user input and compared with the database attributes that needto compare with, during the runtime. The goal behind converting the input to a string is to make user input as a singleunit (one token) that cannot use as a SQL query statement. The system will call the database attribute in such away in whichuser cannot access to the sql statement to do the injection. And the sql query will be empty from any input tools that can use byuser to injects the SQL.

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Bondarenko, I. N. "Ultrasonic diagnosis of cosmetic injectable-induced neuropathy: Clinical cases." Kuban Scientific Medical Bulletin 29, no. 1 (January 25, 2022): 108–18. http://dx.doi.org/10.25207/1608-6228-2022-29-1-108-118.

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Background. Facial nerve injury, ﬁller-induced compression or soft tissue inﬁltrations are among the neuropathic complications of aesthetic injection procedures. The prospects of ultrasound imaging in neuropathy diagnosis are understudied. National and foreign literature does not describe facial soft tissues ultrasound in patients with cosmetic injectable-induced clinical neuropathy.Clinical Cases Description. Two clinical cases are presented of high resolution ultrasound (HRU)-empowered veriﬁcation of injectable cosmetic procedures-induced neuropathy. Ultrasound imaging was proved necessary for differential neuropathic causes diagnosis via the clinical assessment of facial soft tissues, ﬁller and thread depth, as well as topography relative to blood vessels and nerves. In the ﬁrst case, threads were visualised at a 4.6 and 5.8 mm depth from epidermis, which can coincide in location with large facial nerve branches usually running along vessels in deeper subcutaneous fat. Vessels were not detected in immediate proximity to threads along the entire trajectory from implantation to ﬁxation sites by colour Doppler imaging (CDI). The ultrasound pattern corresponded to dermal and soft tissue inﬁltration. In the second case, ultrasound was applied to differentially diagnose a iatrogenic cause of neuropathy, considering a 3-year-past history of ﬁller injection at temporal muscle projection. A ﬁller bolus was revealed adjacent to a vessel in subaponeurotic fat of right temporal region, with inﬁltrative signs of perifocal oedema around a piece of hyaluronic acid. Temporal soft tissue of the opposite facial half remained unchanged. According to HRU evidence, neuropathy developed due to nerve compression by facial soft tissue inﬁltrative distortions after thread implantation in the ﬁrst case and by ﬁller directly in the second. The HRU examination facilitated a correct diagnosis and choice of patient management.Conclusion. Ultrasonography is indicated in patients with cosmetic procedures-induced neuropathy for differential diagnosis of complication causes and current therapy monitoring.

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Haragâş, Simion, Iuliu Negrean, Dumitru Pop, Ovidiu Buiga, and Florina Rusu. "Demolding Moment Calculation for Injected Parts with Internal Trapezoidal Thread." Key Engineering Materials 699 (July 2016): 104–9. http://dx.doi.org/10.4028/www.scientific.net/kem.699.104.

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At the final step of the injection process (of a plastic product with cavities) when the part is on the point to be ejected the adhesion phenomena occurs between the core and the plastic part. The mold adhesion effect has a significant influence on the mold design ejection system and over the whole process. This paper presents a computation methodology of the demolding moment for two cases of plastic injected parts with internal trapezoidal thread. Knowing the value of this moment offer us the possibility to adopt the right design solution of the ejector system and of the entire mold. As further work the author will try to validate this method through a set of practical experiments.

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Walton, Andrew G. "The linear and nonlinear stability of thread-annular flow." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 363, no. 1830 (May 15, 2005): 1223–33. http://dx.doi.org/10.1098/rsta.2005.1564.

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The surgical technique of thread injection of medical implants is modelled by the axial pressure-gradient-driven flow between concentric cylinders with a moving core. The linear stability of the flow to both axisymmetric and asymmetric perturbations is analysed asymptotically at large Reynolds number, and computationally at finite Reynolds number. The existence of multiple regions of instability is predicted and their dependence upon radius ratio and thread velocity is determined. A discrepancy in critical Reynolds numbers and cut-off velocity is found to exist between experimental results and the predictions of the linear theory. In order to account for this discrepancy, the high Reynolds number, nonlinear stability properties of the flow are analysed and a nonlinear, equilibrium critical layer structure is found, which leads to an enhanced correction to the basic flow. The predictions of the nonlinear theory are found to be in good agreement with the experimental data.

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Liu, Ju Bao, Chun Sheng He, and Qian Bei Yue. "The Mechanical Analysis of the Coiled Tubing." Applied Mechanics and Materials 385-386 (August 2013): 154–58. http://dx.doi.org/10.4028/www.scientific.net/amm.385-386.154.

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With respect to the conventional coupling thread, the coiled tubing had the advantages of without screwing on and screwing off in the lifting pipe string. It was widespread used in the drilling and repairing well. According to the actual state of the coiled tubing, the mechanical models on the ground and in the wellbore were established in this article. The were able to simulate the contact state of the coiled tubing through the drum, the guide frame, the injector head and in the wellbore. The curves of the axial force that through the rollers, guide frame, injection head and wellhead was obtained with the changes of the depth.

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Bulej, Vladimír, Nadežda Čuboňová, Manfred Eberth, and Karol Vasilko. "The mould for production of plastic spout cap with internal thread by injection moulding." MATEC Web of Conferences 244 (2018): 01025. http://dx.doi.org/10.1051/matecconf/201824401025.

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The main aim of this article is the mould design for production of plastic spout cap with inner thread by injection moulding technology. There are described the basic steps of whole design process with respect to fulfil all technology and functionality requirements. The application of hot runner system as well as hybrid ejection system based on rotary cores and stripper plate can be considered as the main innovative features of the designed mould. The mould flow analysis was carried out for the functionality demonstration.

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Usui, Hiromoto, Katsuhiro Maeguchi, and Yuji Sano. "Drag reduction caused by the injection of polymer thread into a turbulent pipe flow." Physics of Fluids 31, no. 9 (September 1988): 2518–23. http://dx.doi.org/10.1063/1.866605.

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Agustini, Deonir, Márcio F. Bergamini, and Luiz Humberto Marcolino-Junior. "Simple and Inexpensive Microfluidic Thread Based Device for Teaching Microflow Injection Analysis and Electrochemistry." Journal of Chemical Education 95, no. 8 (July 9, 2018): 1411–14. http://dx.doi.org/10.1021/acs.jchemed.8b00211.

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Agustini, Deonir, Márcio F. Bergamini, and Luiz Humberto Marcolino-Junior. "Tear glucose detection combining microfluidic thread based device, amperometric biosensor and microflow injection analysis." Biosensors and Bioelectronics 98 (December 2017): 161–67. http://dx.doi.org/10.1016/j.bios.2017.06.035.

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Bulej, Vladimir, Ivan Kuric, and Adrian Popescu. "The Mould Design for Production of Plastic Component by Injection Moulding Technology." Applied Mechanics and Materials 808 (November 2015): 161–66. http://dx.doi.org/10.4028/www.scientific.net/amm.808.161.

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The article deals with the design of the mould for plastic component production by injection moulding technology. There are described the basic steps of whole design process how to choose and design the suitable components with respect to fulfilling the technology requirements necessary for high quality products. The mould contains also the rotary cores with respect to the shape and dimensions of produced part, especially the thread surfaces. The mould flow analysis was carried out for the functionality demonstration.

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Xu, Yun Xiang, Cui Jiang, and Gui Zhen Chen. "Applications of Nanomaterials in Acupuncture and Moxibustion Instrument and Materials." Advanced Materials Research 430-432 (January 2012): 933–36. http://dx.doi.org/10.4028/www.scientific.net/amr.430-432.933.

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By analyzing the relationship between nanotechnology and medical science, especially nanotechnology and acupuncture, the application of nanomaterials for needling therapy, acupoint catgut embedding therapy, acupoint external application, acupoint injection therapy, and meridian point diagnosis were discussed. Nanomaterials will make the development of acupuncture possess an unprecedented domain. It’s pointed out that breakthrough will be achieved from the research of the application of nanomaterials on the development of nano-needles for needling therapy, nano-thread for acupoint catgut embedding therapy, nano-medicine for acupoint external application therapy, nano-drug carrier for acupoint injection therapy, nano-sensor for meridian and acupoint diagnosis.

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Gribanov, I. I., and Natalia Yu Starokozheva. "Thread lifting and single-step facial volumization as an optimum balanced technique of aesthetic correction." Russian Journal of Skin and Venereal Diseases 23, no. 5 (October 15, 2020): 347–53. http://dx.doi.org/10.17816/dv59699.

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BACKGROUND: Development and introduction of minimally invasive lifting techniques is considered a demanding and relevant objective of contemporary dermatocosmetology as these techniques result in nonsurgical lifting with minimal disruption of facial harmony due to the activation of a maximal number of key anatomic landmarks following the simultaneous insertion of lifting threads and hyaluronic acid fillers. AIMS: To study the clinical efficacy and safety of minimally invasive lifting technique and filling up of the tissue volume deficiency with the combination of thread lifting from the temporal approach and hyaluronic acid filler augmentation. MATERIALS AND METHODS: The study group included 193 female patients (mean age 41.3 8.5 years) with gravitational ptosis of the 1st, 2nd, and 3rd degrees. Group 1 (main) comprised 42 (21.8%) patients who underwent lifting by the method of implantation of 12 threads with shaped polydioxanone spikes DG-Lift and injection of 2 ml of hyaluronic acid biphasic filler. Group 2 (comparison) comprised 64 (33.2%) female patients who underwent lifting using only 1220 polydioxanone DG-Lift threads. Group 3 (comparison) comprised 87 (45%) female patients who received tissue volumization with 48 ml of biphasic hyaluronic acid filler in each case. RESULTS: A total of 82%, 59%, and 48% of patients in groups 1, 2, and 3, respectively, noted the optimal cosmetic result and full satisfaction with the result according to the Global Aesthetic Improvement Scale. The incidence of complications in group 1 (6.4%) was lower than that in group 2 (9.1%) and group 3 (17.7%). This is due to low invasive nature and lower tissue traumatization with the use of fewer fillers and threads to obtain optimal cosmetic effect. CONCLUSION: The proposed technique of thread lifting with biodegradable threads DG-Lift from the temporal approach combined with tissue volumization with hyaluronic acid fillers is safe and significantly effective for patients with gravitational ptosis of the 1st, 2nd, and 3rd degrees.

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Agustini, Deonir, Márcio F. Bergamini, and Luiz Humberto Marcolino-Junior. "Characterization and optimization of low cost microfluidic thread based electroanalytical device for micro flow injection analysis." Analytica Chimica Acta 951 (January 2017): 108–15. http://dx.doi.org/10.1016/j.aca.2016.11.046.

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Banerjee, Swagatam, Saurav Sarkar, Sanjoy Ghosh, Sharmistha Chakravarty, and Biswajit Sikder. "A Novel Technique of Branchial Fistula Tract Delineation and Excision In Children Allergic To Dyes." Bengal Journal of Otolaryngology and Head Neck Surgery 23, no. 2 (August 1, 2015): 43–47. http://dx.doi.org/10.47210/bjohns.2015.v23i2.42.

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IntroductionBranchial arch fistula which results from a second arch anomaly is rarely seen in practice. The patients usually seek medical advice for persistent discharge from an opening in the neck or mucopurulent discharge from the opening of an infected fistulous tract. The treatment of choice for such a fistula is excision. Materials and MethodsA total of seven patients were operated for branchial fistula between 2010 and 2012. Among them, three children could not undergo a fistulogram due to allergy to the dye used and hence they were selected for our modified procedure. Surgical ProcedureA 3-0 or 4-0 polypropylene (Prolene™) thread was inserted into the fistulous tract. Both the ends of the tract were secured with the thread and the sinus tract was dissected out under gentle traction. ResultsThe patients who were allergic to dye could not have preoperative fistulograms and per-operative injection of dye was also avoided. The blue colour of the polypropylene thread inserted in the fistula tract helped in tracing and excision of the sinus tract. No major complications occurred during or after fistulectomy and the post-operative recovery was uneventful. No recurrence was seen in the scheduled follow-ups. ConclusionSurgical excision of branchial fistulas in children with allergy to dyes can be challenging. Insertion of a polypropylene thread into the fistula tract makes its subsequent dissection easy with minimal disruption of adjacent structures.

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Khoshavi, Navid, Hamid Zarandi, and Mohammad Maghsoudloo. "Two control-flow error recovery methods for multithreaded programs running on multi-core processors." Facta universitatis - series: Electronics and Energetics 28, no. 3 (2015): 309–23. http://dx.doi.org/10.2298/fuee1503309k.

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This paper presents two control-flow error recovery techniques, CFE Recovery using Data-flow graph Consideration and CFE Recovery using Macro block-level Check pointing. These techniques are proposed with regards to thread interactions in the programs. These techniques try to moderate the high memory and performance overheads of conventional control-flow checking techniques. The proposed recovery techniques are composed of two phases of control-flow error detection and recovery. These phases are designed by means of inserting additional instructions into program at compile time considering dependency graph, extracted from control-flow and data-flow dependencies among basic blocks and thread interactions in the programs. In order to evaluate the proposed techniques, five multithreaded benchmarks are utilized to run on a multi-core processor. Moreover, a total of 10000 transient faults have been injected into several executable points of each program. Fault injection experiments show that the proposed techniques recover the detected errors at-least for 91% of the cases.

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MEKHEIMER, KH S., Y. ABD ELMABOUD, and A. I. ABDELLATEEF. "PARTICULATE SUSPENSION FLOW INDUCED BY SINUSOIDAL PERISTALTIC WAVES THROUGH ECCENTRIC CYLINDERS: THREAD ANNULAR." International Journal of Biomathematics 06, no. 04 (July 2013): 1350026. http://dx.doi.org/10.1142/s1793524513500265.

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This paper describes a new model for obtaining analytical solutions of peristaltic flow through eccentric annuli. A mathematical model of peristaltic pumping of a fluid mixture (as blood model) in a circular eccentric cylinders is presented and it is motivated due to the fact that thread injection is a promising method for placing medical implants within the human body with minimum surgical trauma. For the eccentric annuli, the inner cylinder is rigid and moving with a constant velocity V, and the outer one is hollow flexible cylinder that has a sinusoidal wave traveling down its wall. The coupled differential equations for both the fluid and the particle phases have been solved by using two methods and the expressions for the velocity distribution of fluid and particle phase, flow rate, pressure drop, friction forces at the inner and outer cylinders have been derived. The results obtained are discussed in brief. The significance of the particle concentration and the eccentricity parameter as well as the nature of the basic flow has been well explained.

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Li, Jin Guo, Xiao Gui Wang, and Zeng Liang Gao. "Numerical Simulation and Experimental Research on Fatigue Strength of the Injector Guide Pillar under Complex Loads." Advanced Materials Research 118-120 (June 2010): 196–200. http://dx.doi.org/10.4028/www.scientific.net/amr.118-120.196.

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Under the complex loads, the injector guide pillar (IGP) used in injection machine was failure only after 1.5-year-service. In order to determine the cause of the fracture, the numerical simulation technology was applied to analyze the mechanical properties of the IGP. The contact between the mating surfaces of the clamping mechanism was modeled; nonlinear multi-region contact of surface-surface was applied to establish the contact model of FEA. The constraint of tie was used for modeling thread joint. The simulated results indicated that the smaller area of contact surface, the higher value of stress in the neck of IGP. Electronic measurement was also used to check the results of stress in IGP obtained by FEA. It was found that the experimental data agreed well with simulated results. Based on the numerical analysis and experimental study, the structure of IGP was improved by adopting a smoother double-round neck. The fatigue life of the improved structure was longer than that of the original machine.

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Zheng, Shicheng, Yongling Fu, Jian Sun, and Ziyu Liu. "Design of Redundant Manipulator System for Water Injection of EMU Train." Journal of Physics: Conference Series 2396, no. 1 (December 1, 2022): 012034. http://dx.doi.org/10.1088/1742-6596/2396/1/012034.

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Abstract Robots are known as "the Pearl at the top of the crown of manufacturing." As the most common kind of robot, the multi-degree-of-freedom manipulator has its reliability, lightweight, integration, and modularization, which are the focus of researchers. Based on the background of injecting water into the EMU train, this paper uses the water feeding manipulator (WFM) to completely replace the manual operation and researches the key technology of the redundant manipulator system. At the component level, a new type of planetary thread roller bearing (PTRB) is used as the main bearing component of the manipulators’ joint. For joint, two integrated joint modules (IJM) are developed based on PTRB to be an option for IJM with a high power-weight ratio and high reliability. Finally, for the system, according to the fault-tolerant performance requirements of the task point, the redundant manipulator system architecture is proposed, the mechanical body is set as the redundant structure, the driver and controller are dynamically reconstructed, and the control algorithm and fault diagnosis are fault-tolerant. The failure rate is 3.257×10-8/h, laying the foundation for the realization of a fully automatic and intelligent train water supply.

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Ghosh, Ajoy Kumar, Noriyasu Hirasawa, Hiroshi Ohtsu, Takehiko Watanabe, and Kazuo Ohuchi. "Defective Angiogenesis in the Inflammatory Granulation Tissue in Histidine Decarboxylase–deficient Mice but not in Mast Cell–deficient Mice." Journal of Experimental Medicine 195, no. 8 (April 8, 2002): 973–82. http://dx.doi.org/10.1084/jem.20011782.

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We have analyzed the role of histamine in the angiogenesis of the granulation tissue in histidine decarboxylase–deficient (HDC−/−) mice, mast cell–deficient mice (WBB6F1-W/WV), and their corresponding wild-type mice (HDC+/+ and WBB6F1+/+). In HDC+/+ mice, subcutaneous implantation of a cotton thread in the dorsum induced granulation tissue formation with angiogenesis, while the topical injection of antivascular endothelial growth factor (VEGF) IgG strongly suppressed them. In HDC−/− mice which showed lower VEGF levels in the granulation tissue, there was notably less angiogenesis and granulation tissue formation than in HDC+/+ mice. The topical injection of histamine or the H2 agonist dimaprit rescued the defective angiogenesis and granulation tissue formation in HDC−/− mice. There was no significant difference in the granulation tissue formation and angiogenesis between WBB6F1-W/WV and WBB6F1+/+ mice. In addition, macrophages in the granulation tissue were found to express HDC. Our findings indicate that histamine derived from nonmast cells plays a significant role in the angiogenesis of the inflammatory granulation tissue.

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Park, Jin Hyung, Eon Ju Park, and Hyung Suk Yi. "Wound Healing and Anti-inflammatory Effects of Topical Hyaluronic Acid Injection in Surgical-Site Infection Caused by Staphylococcus aureus." International Journal of Lower Extremity Wounds 16, no. 3 (June 15, 2017): 202–7. http://dx.doi.org/10.1177/1534734617714142.

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Surgical-site infection (SSI) is a common postoperative complication, primarily caused by Staphylococcus aureus. S aureus produces hyaluronidase which degrades hyaluronic acid (HA). HA prevents bacterial proliferation and has anti-inflammatory effects to promote wound healing. We evaluated the effect of HA injection with systemic antibiotics for prevention and treatment of SSIs caused by S aureus. An open wound was created on the dorsum of 40 rats. The wound bed was sutured with S aureus inoculated thread. The test group was injected with HA (HA group), and the control group received a subcutaneous injection of normal saline (NS group). All groups were then treated with intraperitoneal cefazolin injection. The sutures were removed 2 days after the procedure. Gross pathology, bacterial count, and wound histology were assessed at days 2, 4, 6, and 8 postprocedure. The HA group showed a significant reduction in the wound area compared with the control group on gross pathology (at days 8 postprocedure, 36.54% ± 6.12% vs 50.59% ± 5.50%, P < .001). The HA group showed significantly better wound healing than the control group on histological analysis, including assessment of abscess, neutrophilic infiltration, and necrosis (4.2 ± 1.2 vs 11.5 ± 2.1, P < .001). The HA group showed a lower bacterial count compared with the NS group, but the result was not significant statistically (at days 6 postprocedure, 5.11 ± 0.31 vs 5.91 ± 0.35 logCFU/mL, P = .706). In conclusion, immediate local injection of HA in wounds can reduce SSI occurrence and promote wound healing in an animal model.

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Deepthi, V. V. Naga, and Prof K. Govinda Rajulu. "Optimization of Inlet and Exhaust Manifold on a Single Cylinder Diesel Engine to Enhance the Combustion." International Journal of Innovative Technology and Exploring Engineering 8, no. 10 (August 30, 2019): 1408–11. http://dx.doi.org/10.35940/ijitee.j1004.0881019.

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In the internal combustion Diesel engines the most important subsystem is Intake manifold and Exhaust manifold. In the intake manifold which supplies fresh air –fuel mixture in to the cylinders where combustion takes place at high temperature and high pressure. After exhaust gases scavenged through valves from the cylinders, these gases past exhaust manifold an outlet, through which the gases flow into exhaust pipes from there to the emission control equipment of engine which consists of catalytic and thermal converters. The development of swirl can be enhanced by re-designing of inlet port of an Engine. There is further development in the swirl due to combustion process to another maximum part way in to the power stroke. Swirl can promotes the combustion process in a better way and causes efficiency increase. Better mixing of air – fuel there is a little bit changing the inlet and exhaust valve. Valve stem diameter is 9.5mm, Inlet valve diameter is 36mm, Exhaust Valve diameter is 28mm by varying the pitch 1.0mm to 2mm and thread depth of cut as 4mm and three thread per inch from this arrangement to investigate the performance by enhancing the swirl of air flow to get betterment in the performance and decrease in emissions in a (DI) direct injection diesel engine with single cylinder when compared with normal engine.

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DEFINO, H. L. A., C. H. BARBIERI, R. P. GONCALVES, and J. B. P. PAULIN. "Studies on Tendon Healing A Comparison Between Suturing Techniques." Journal of Hand Surgery 11, no. 3 (June 1986): 444–50. http://dx.doi.org/10.1016/0266-7681_86_90178-6.

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An experimental study comparing Kessler’s and Tsuge’s techniques for tendon suture was undertaken in dogs. Both second and fifth flexor digitorum profundi tendons of the left forepaw were divided in the segment corresponding to zone 2 of human hands. Following division, the tendons to the second digit were repaired by Kessler’s technique and those to the fifth digit by Tsuge’s method. Results were evaluated by means of standard and polarized – light microscopy, intravascular dye injections and tensile strength tests. Both ordinary and polarized – light microscopy showed that a microscopical gap develops between the tendon ends, being filled in with healing tissue which undergoes progressive maturation. The tensile strength tests showed that the deformation (elongation) progress directly with load, up to the point of rupture; the suture thread does not interfere with this. Furthermore, strength increases with time. Intravascular dye injection showed that a net of newly formed blood vessels develops at the site of section and suture, previously destitute of macroscopical vessels. The new vessels tended to redistribute them selves to resemble the pattern in normally vascularized regions. It was not possible to detect, by means of the methods employed, any important difference between Kessler’s and Tsuge’s techniques for tendon suture.

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Chang, Guo-Wei, and Jun-Min Yang. "A Method for Automatic Thread Demoulding Using Step Motor and Servo Motor with Synchronization between the Two Systems in Injection Mould." Research Journal of Applied Sciences, Engineering and Technology 6, no. 13 (August 5, 2013): 2489–94. http://dx.doi.org/10.19026/rjaset.6.3727.

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Fletcher, D., V. Kayser, and G. Guilbaud. "Influence of Timing of Administration on the Analgesic Effect of Bupivacaine Infiltration in Carrageenin-injected Rats." Anesthesiology 84, no. 5 (May 1, 1996): 1129–37. http://dx.doi.org/10.1097/00000542-199605000-00015.

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Background Recent evidence has suggested that the timing of administration of analgesic drugs could influence their efficacy by reducing the sensitization of the nervous system induced by the nociceptive inputs, but this concept of preemptive analgesia is still debated in both clinical and basic research. Methods The model of acute inflammatory pain induced by carrageenin was used to study the influence of timing of administration of bupivacaine (0.2 ml of a 0.5% solution with 0.005 mg/ml epinephrine) on the development of hyperalgesia, edema, and increase in temperature. The animals received bupivacaine 5 min before (BUPI PRE group, n = 20) or 60 min after (BUPI POST group, n = 20) carrageenin (1 ml/kg of 1% solution) was injected into the left hind paw. Two control groups (n = 15 in each) received saline 5 min before or 60 min after administration of carrageenin. Hyperalgesia of the injected paw was evaluated by the vocalization threshold to paw pressure, edema by measuring paw circumference with a thread, and plantar temperature with a thermocouple thermometer. All measurements were done before carrageenin injection then every 30 min thereafter for 240 min. Another series (n = 24), with the same four groups was also evaluated at 24 h. Results Local injection of bupivacaine 60 min after carrageenin partially reduced the edema and hyperalgesia. The injection of bupivacaine 5 min before carrageenin was more efficient than the delayed injection and reduced hyperalgesia, edema and the increase in temperature temporarily, but did not totally prevent their development. All groups were similar at 240 min and 24 h. Conclusions These results show that a slight advantage of infiltration with bupivacaine before injury exists in this carrageenin model of acute inflammatory pain. However, this benefit is limited in time and bupivacaine did not have any preemptive analgesic effect.

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Cui, Lu, Fanfan Qiao, Meng Li, Yiming Xiao, and Jiarui Cheng. "Study on the Effect of Fracturing Pump Start and Stop on Tubing Fluid-Structure Interaction Vibration in HPHT Wells via MOC." Energies 15, no. 24 (December 7, 2022): 9291. http://dx.doi.org/10.3390/en15249291.

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The processes of HTHP well fracturing, oil drive, and gas recovery are accompanied by the non-stationary flow of medium in the tubing, which may lead to periodic vibration and cause the failure and fatigue of the tubing, thread leakage, and bending deformation. In this paper, a fluid–structure interaction model with 4-equation was established, which considered the unsteady flow of fluid and the motion state of tubing during the periodic injection, pump start, and shutdown of fluid in the tubing. Further, the discrete solution of MOC was used to obtain the variation of fluid flow rate and pressure, tubing vibration rate, frequency, and additional stress with time. The resonance construction parameters corresponding to different tubing diameters were analyzed by discussing the effects of different start and shutdown times as well as pressure on the tubing vibration parameters. The results show that under the periodic injection condition, increasing the tubing diameter or start inside pressure would lead to a sharp increase in the axial additional stress of the tubing generated by fluid–structure interaction, which is not conducive to the safety protection of the tubing. When the pump was shutdown, excessively short operation times and high pressure in the tubing would lead to excessive transient loads in addition to resonance, which would cause damage to the pipeline. Finally, corresponding to the above analysis results, this paper proposes the optimal injection parameters to avoid the generation of resonance, which provides a theoretical basis and reference range for the safe service conditions of the tubing.

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Omura, Kazuhiro, Kazuhiro Nomura, Teppei Takeda, Norihiro Yanagi, Hiroki Kuroyanagi, Taichi Yanagihara, Yasuhiro Tanaka, Hiromi Kojima, and Nobuyoshi Otori. "How I Do It: Inferior Turbinectomy: Modified Techniques for Submucosal Resection." Allergy & Rhinology 12 (January 2021): 215265672110347. http://dx.doi.org/10.1177/21526567211034736.

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Although inferior turbinectomy with submucosal resection effectively reduces the volume of the inferior turbinate, there is room for improvement in surgical procedures. Techniques have been developed to reduce crusting and bleeding while efficiently achieving volume reduction. State-of-the-art procedures pertaining to the local injection site, incision line, exposure of the periosteum, submucosal outfracture of the turbinate bone, trimming of redundant mucosa, and incision line suturing are described. Pre and postoperative Nasal Obstruction Symptom Evaluation (NOSE) scores and postoperative inferior turbinate bleeding and crusting were evaluated. For the 18 consecutive patients analyzed, the pre and postoperative NOSE scores were 67.8 ± 14.8 and 16.1 ± 13.0, respectively ( P = .0002). Postoperatively, bleeding was absent, and only minor suture thread crusting was observed in 13 patients. In conclusion, our novel technique improves the effectiveness of surgery as well as the postoperative quality of the inferior turbinate.

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Ferrer, Isidro, Pol Andrés-Benito, Margarita Carmona, and José Antonio del Rio. "Common and Specific Marks of Different Tau Strains Following Intra-Hippocampal Injection of AD, PiD, and GGT Inoculum in hTau Transgenic Mice." International Journal of Molecular Sciences 23, no. 24 (December 14, 2022): 15940. http://dx.doi.org/10.3390/ijms232415940.

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Heterozygous hTau mice were used for the study of tau seeding. These mice express the six human tau isoforms, with a high predominance of 3Rtau over 4Rtau. The following groups were assessed: (i) non-inoculated mice aged 9 months (n = 4); (ii) Alzheimer’s Disease (AD)-inoculated mice (n = 4); (iii) Globular Glial Tauopathy (GGT)-inoculated mice (n = 4); (iv) Pick’s disease (PiD)-inoculated mice (n = 4); (v) control-inoculated mice (n = 4); and (vi) inoculated with vehicle alone (n = 2). AD-inoculated mice showed AT8-immunoreactive neuronal pre-tangles, granular aggregates, and dots in the CA1 region of the hippocampus, dentate gyrus (DG), and hilus, and threads and dots in the ipsilateral corpus callosum. GGT-inoculated mice showed unique or multiple AT8-immunoreactive globular deposits in neurons, occasionally extended to the proximal dendrites. PiD-inoculated mice showed a few loose pre-tangles in the CA1 region, DG, and cerebral cortex near the injection site. Coiled bodies were formed in the corpus callosum in AD-inoculated mice, but GGT-inoculated mice lacked globular glial inclusions. Tau deposits in inoculated mice co-localized active kinases p38-P and SAPK/JNK-P, thus suggesting active phosphorylation of the host tau. Tau deposits were absent in hTau mice inoculated with control homogenates and vehicle alone. Deposits in AD-inoculated hTau mice contained 3Rtau and 4Rtau; those in GGT-inoculated mice were mainly stained with anti-4Rtau antibodies, but a small number of deposits contained 3Rtau. Deposits in PiD-inoculated mice were stained with anti-3Rtau antibodies, but rare neuronal, thread-like, and dot-like deposits showed 4Rtau immunoreactivity. These findings show that tau strains produce different patterns of active neuronal seeding, which also depend on the host tau. Unexpected 3Rtau and 4Rtau deposits after inoculation of homogenates from 4R and 3R tauopathies, respectively, suggests the regulation of exon 10 splicing of the host tau during the process of seeding, thus modulating the plasticity of the cytoskeleton.

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Mitschang, P., A. Ogale, J. Schlimbach, F. Weyrauch, and C. Weimer. "Preform Technology: A Necessary Requirement for Quality Controlled LCM-Processes." Polymers and Polymer Composites 11, no. 8 (November 2003): 605–22. http://dx.doi.org/10.1177/096739110301100801.

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A considerable number of process versions of Liquid Composite Moulding (LCM) technologies have been commercialised during the last few years. Only recently there have been attempts to reduce costs and to implement more complex components by the application of preform technology. This article indicates the most appropriate application fields for LCM techniques for the manufacture of fibre reinforced polymers. Different LCM methods are described and summarised. The preforming techniques and particularly the sew -and -cut philosophy for developing a tailored reinforcement is explained. Investigations designed to elucidate the influence of sewing parameters and thread properties have led to an understanding of the requirements and preform characteristics needed to operate the quality controlled LCM process. Some concepts related to the control of the resin injection are described, and a realization of a decision-tree-concept is shown. Finally, a comparison of cost effects for different preforming methods shows a need to define a “critical preforming effort” to manufacture quality components as well as economically optimised parts.

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Isametova, Madina, Bakhyt Absadykov, Bauyrzhan Bazarbay, and Gulbarshyn Smailova. "Development of the design and technology of extrusion of metal-polymer mixtures for the production of feedstocks." Eastern-European Journal of Enterprise Technologies 4, no. 1 (118) (August 31, 2022): 23–33. http://dx.doi.org/10.15587/1729-4061.2022.259532.

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The paper is devoted to the development of new equipment for the production of metal-polymer thread. 3D printing with metal-polymer thread is one of the advanced directions in the technology of manufacturing metal parts of complex shape. The proposed technology is an alternative to the currently existing metal injection molding (MIM) technology and selective laser melting printing technology. An important step in this work was to conduct computational experiments to determine the effect of screw rotation on the process pressure parameter and the design of the main assembly of the screw extruder. As a result of the research, the pressures on the metal-polymer composition were determined depending on the rotation speed of the screw. With a rotation of 30 rpm, the pressure reached 0.05 Pa and the maximum pressure was 0.18 MPa. The experiments were carried out in the CradelSFlow program. The computer calculation showed a margin of the screw strength coefficient k=1.8, and a maximum deflection of 2.8∙10–4 m, which meets the condition of static rigidity. To determine the correct value of the gap δ between the screw ridge and the extruder walls, an analysis of the rotor dynamics was carried out. The result of this study is the critical extruder rotation speed of 60 rpm at which the phenomenon of precession may occur. Amplitude-frequency characteristics ydin=7∙10–4 m. According to the results of the dynamic calculation, the screw dimensions were adjusted, the geometry was reduced by ∆=0.5 mm. The experiments made it possible to verify the optimal parameters of the technological process of metal-polymer mixture extrusion. The data obtained are important for the improvement and development of 3D printing technology for metal parts of complex geometric shape.

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Lucaciu, Ondine, Radu Septimiu Campian, Olga Soritau, Cristian Berce, Alexandru Mester, Dragos Apostu, Flaviu Tabaran, et al. "Dental Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study." Revista de Chimie 69, no. 7 (August 15, 2018): 1785–90. http://dx.doi.org/10.37358/rc.18.7.6417.

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The goal of periodontal therapy is to regenerate the periodontal structures: cement, periodontal ligament and alveolar bone. Stem cell-based tissue engineering raised novel therapeutic strategies for periodontal repair. In vivo dental follicle stem (DFSC) cells give rise to cementoblasts, osteoblasts and fibroblasts. Based on this idea, we have assessed DFSC potential to regenerate the periodontal structures, and by that to elaborate a new biomaterial. An experimental study was performed on male Wistar rats which were subjected to a procedure of periodontitis induction through placing silk thread ligatures around the lower incisors, under general anesthesia. Clinically, the changes of the periodontal tissue (bleeding on probing, dental mobility, dental plaque, presence of pus) induced by the periodontitis progression were daily assessed. The subjects were divided in two groups: a control and a study group. After 7 days from placing silk thread ligatures, subjects from the study group received an injection in the gingival sulcus. The injected biomaterial contained dental follicle stem cells seeded on fibrinogen. Bleeding on probing at the end of the treatment period was significantly reduced in the study group (study vs control group - 0% vs 100%, p=0.01.). In terms of dental mobility statistical significant results were obtained (p=0.04): for 20% from the subjects from the study group dental mobility was absent, while in the control group all subjects presented different degrees of mobility (33.3% degree II- v-o/m-d, 66.6% degree III-v-o/m-d/ax). In the control group pus was present in 66.7% from the subjects, and absent in the study group (p=0.10). Dental plaque was present in 40% of the subjects from the study group and in 100% in the control group. The clinical and histological results of our study demonstrate that dental follicle stem cells are a valuable cell source for tissue engineering the periodontal tissue.

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Zhang, Pei-Lei, Hai-Tao Lu, Jun-Gong Zhao, and Ming-Hua Li. "Protective effect of dl-3n-butylphthalide preconditioning on focal cerebral ischaemia-reperfusion injury in rats." Acta Neuropsychiatrica 25, no. 1 (February 2013): 12–17. http://dx.doi.org/10.1111/j.1601-5215.2012.00649.x.

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ObjectiveTo investigate the effect of dl-3n-butylphthalide (NBP) on the protection of cerebral tissue and possible mechanism on ischaemia-reperfusion injury, and to find out whether NBP therapy can extend the reperfusion window in an experimental stroke model in rats.MethodsSeventy-two Sprague-Dawley rats were randomly divided into sham operation, ischaemia-reperfusion and ischaemia-reperfusion with NBP groups. Focal cerebral ischaemia was induced using the modified intraluminal thread method and maintained for 2, 3 or 4 h. The ischaemia-reperfusion group received reperfusion immediately after ischaemia-reperfusion. The NBP group received intraperitoneal injection of NBP immediately after ischaemia, followed by reperfusion. The sham operation group received only injection of physiological saline. The cerebral infarction volume and neurological deficit were analysed, and vascular endothelial growth factor (VEGF) expression in brain tissues was visualised by immunohistochemistry.ResultsNBP treatment caused a significant decrease in both infarction volume and neurological deficit compared with the ischaemia-reperfusion group at corresponding time points in each (p < 0.05). In the NBP group, the infarction volume and neurological deficit did not change with different ischaemia times. The expression of VEGF was significantly decreased in the ischaemia-reperfusion group compared with the sham group (p < 0.01), while this change was partly prevented in the NBP group (p < 0.01). The expression of VEGF in brain tissue in both the NBP and ischaemia-reperfusion groups gradually decreased when the ischaemic period was prolonged.ConclusionNBP treatment has a protective effect against cerebral ischaemia; this possible mechanism maybe related to the VEGF expression and may extend the reperfusion window for subsequent salvage of cerebral ischaemia by reperfusion.

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Yang, Lishan, Bin Nie, Adwait Jog, and Evgenia Smirni. "SUGAR." Proceedings of the ACM on Measurement and Analysis of Computing Systems 5, no. 1 (February 18, 2021): 1–29. http://dx.doi.org/10.1145/3447375.

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As Graphics Processing Units (GPUs) are becoming a de facto solution for accelerating a wide range of applications, their reliable operation is becoming increasingly important. One of the major challenges in the domain of GPU reliability is to accurately measure GPGPU application error resilience. This challenge stems from the fact that a typical GPGPU application spawns a huge number of threads and then utilizes a large amount of potentially unreliable compute and memory resources available on the GPUs. As the number of possible fault locations can be in the billions, evaluating every fault and examining its effect on theapplication error resilience is impractical. Application resilience is evaluated via extensive fault injection campaigns based on sampling of an extensive fault site space. Typically, the larger the input of the GPGPU application, the longer the experimental campaign. In this work, we devise a methodology, SUGAR (Speeding Up GPGPU Application Resilience Estimation with input sizing), that dramatically speeds up the evaluation of GPGPU application error resilience by judicious input sizing. We show how analyzing a small fraction of the input is sufficient to estimate the application resilience with high accuracy and dramatically reduce the duration of experimentation. Key of our estimation methodology is the discovery of repeating patterns as a function of the input size. Using the well-established fact that error resilience in GPGPU applications is mostly determined by the dynamic instruction count at the thread level, we identify the patterns that allow us to accurately predict application error resilience for arbitrarily large inputs. For the cases that we examine in this paper, this new resilience estimation mechanism provides significant speedups (up to 1336 times) and 97.0 on the average, while keeping estimation errors to less than 1%.

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Yang, Lishan, Bin Nie, Adwait Jog, and Evgenia Smirni. "SUGAR: Speeding Up GPGPU Application Resilience Estimation with Input Sizing." ACM SIGMETRICS Performance Evaluation Review 49, no. 1 (June 22, 2022): 45–46. http://dx.doi.org/10.1145/3543516.3453917.

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As Graphics Processing Units (GPUs) are becoming a de facto solution for accelerating a wide range of applications, their reliable operation is becoming increasingly important. One of the major challenges in the domain of GPU reliability is to accurately measure GPGPU application error resilience. This challenge stems from the fact that a typical GPGPU application spawns a huge number of threads and then utilizes a large amount of potentially unreliable compute and memory resources available on the GPUs. As the number of possible fault locations can be in the billions, evaluating every fault and examining its effect on the application error resilience is impractical. Application resilience is evaluated via extensive fault injection campaigns based on sampling of an extensive fault site space. Typically, the larger the input of the GPGPU application, the longer the experimental campaign. In this work, we devise a methodology, SUGAR (Speeding Up G PGPU Application Resilience Estimation with input sizing), that dramatically speeds up the evaluation of GPGPU application error resilience by judicious input sizing. We show how analyzing a small fraction of the input is sufficient to estimate the application resilience with high accuracy and dramatically reduce the duration of experimentation. Key to our estimation methodology is the discovery of repeating patterns as a function of the input size. Using the well-established fact that error resilience in GPGPU applications is mostly determined by the dynamic instruction (DI) count at the thread level, we discover the patterns that allow to accurately predict application error resilience for arbitrarily large inputs. For the cases that we examine in this paper, this new resilience estimation provides significant speedups (up to 1336 times) and 97.0 on the average, while keeping estimation errors to less than 1%, for details see the full version of this SIGMETRICS paper.

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Ziablitsev, D. S., O. O. Dyadik, A. O. Tikhomirov, M. M. Tsvetkova, and S. V. Ziablitsev. "CHANGES IN THE CONTENT AND FEATURES OF LOCALIZATION OF ANGIOTENSIN-CONVERTING ENZYME-2 (ACE2) IN ACUTE EXPERIMENTAL BRONCHOPNEUMONIA." Fiziolohichnyĭ zhurnal 68, no. 3 (June 15, 2022): 24–34. http://dx.doi.org/10.15407/fz68.03.024.

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Coronavirus (SARS-CoV-2) enters the cell by binding to a transmembrane glycoprotein, angiotensin-converting enzyme-2 (ACE2), which is expressed on the surface of the bronchial and alveolar epithelium. In this regard, the aim of this study was to determine changes in the content and characteristics of tissue localization of ACE2 in the model of acute bronchopulmonary inflammation. The latter was modeled by endotracheal injection of a foreign body (Capron thread) and a solution of lipopolysaccharide (LPS; 50 μl at a dose of 12.5 mg/kg) against the background of systemic administration of LPS for two days before surgery (250 mg/ kg). ACE2 localization and quantity were evaluated by immunohistochemical and western blot assays with the use of a specific monoclonal antibody. The experiment reproduced acute exudative-hemorrhagic bronchopneumonia with the development of diffuse progressive pulmonary fibrosis with lethality in 36% of animals. Acute exudative inflammation was accompanied by complete inhibition of ACE2 expression in bronchial epitheliocytes and its significant decrease in alveolocytes type II. With the development of the proliferative stage of bronchopneumonia, the level of ACE2 was restored, subsequently remaining without significant changes. The obtained experimental data suggest the existence of a relationship between the features of quantitative changes in the ACE2 level in the bronchopulmonary epithelium and the undulating course of the inflammatory process during SARS-CoV-2 infection.

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Chen, Min, Min Chen, Suren Chen, Jingjing Zhou, Fangfang Dong, Zhiming Shen, Haowei Wu, Xiuhong Cui, and Fei Gao. "Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation of Gonad Somatic Cell." Oxidative Medicine and Cellular Longevity 2019 (September 5, 2019): 1–8. http://dx.doi.org/10.1155/2019/8030697.

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The interaction between germ cell and somatic cell plays important roles in germ cell development. However, the exact function of gonad somatic cell in germ cell differentiation is unclear. In the present study, the function of gonad somatic cell in germ cell meiosis was examined by using mouse models with aberrant somatic cell differentiation. In Wt1R394W/R394W mice, the genital ridge is absent due to the apoptosis of coelomic epithelial cells. Interestingly, in both male and female Wt1R394W/R394W germ cells, STRA8 was detected at E12.5 and the scattered SYCP3 foci were observed at E13.5 which was consistent with control females. In Wt1-/flox; Cre-ERTM mice, Wt1 was inactivated by the injection of tamoxifen at E9.5 and the differentiation of Sertoli and granulosa cells was completely blocked. We found that most germ cells were located outside of genital ridge after Wt1 inactivation. STRA8, SYCP3, and γH2AX proteins were detected in germ cells of both male and female Wt1-/flox; Cre-ERTM gonads, whereas no thread-like SYCP3 signal was observed. Our study demonstrates that aberrant development of gonad somatic cells leads to ectopic expression of meiosis-associated genes in germ cells, but meiosis was arrested before prophase I. These results suggest that the proper differentiation of gonad somatic cells is essential for germ cell meiosis.

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Stuart, Patrick, Xiao-Tang Yin, Chelsea Del Rosso, Chloe Potter, Chloe Potter, and Devin West. "Neutralizing KC (CXCL1), but not IL-6 ameliorates recurrent HSK in vivo. (P6340)." Journal of Immunology 190, no. 1_Supplement (May 1, 2013): 182.22. http://dx.doi.org/10.4049/jimmunol.190.supp.182.22.

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Abstract Herpetic stromal keratitis (HSK) is the leading cause of infectious blindness in developed nations and occurs following infection with herpes simplex virus. The mechanism underlying this disease is immune-mediated, involving neutrophils, macrophages, cytokines, and chemokines. We hypothesized that neutralizing the proinflammatory cytokine IL-6 or the chemokine KC (murine CXCL1) would significantly reduce disease in an animal model of HSK. Latently infected mice were reactivated 6 weeks following infection with UV-B light to stimulate recurrent disease. At that time, we administered mAbs against IL-6, KC and control IgG via intraperitoneal injection. We monitored recurrent infection by daily testing tear film for virus for 7 days following reactivation. Corneal disease was evaluated weekly for five weeks. Data shows that neutralizing KC resulted in lower opacity and neovascularization scores for all time points measured when compared to controls. Surprisingly, unlike what is seen in acute HSK, neutralizing IL-6 did not decrease disease. Futhermore, treatment with anti-KC results in significantly less neutrophilic infiltrate of infected corneas. We conclude that CXCL1 and not IL-6 is important in developing recurrent HSK. Furthermore, these results further demonstrate that recurrent and acute HSK share some but not all aspects of disease, and that one common thread is the crucial role that neutrophils play in this potentially blinding disease.

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Kim, Mee, HyunJeong Jeong, Ryu Jin Suk, Dong Hyun Kim, and Won Ryang Wee. "Effect of anti-high mobility group box 1 on innate lymphoid cells of dry eyes in mouse model of Sjögren syndrome (MUC2P.927)." Journal of Immunology 194, no. 1_Supplement (May 1, 2015): 65.10. http://dx.doi.org/10.4049/jimmunol.194.supp.65.10.

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Abstract How innate lymphoid cells (ILCs) secrete cytokines is not well understood. High mobility group box (HMGB) may be involved in secreting IL17 or IL22 in ILCs. Extracellular HMGB1 may be related with the pathogenesis of Sjögren syndrome. We here investigated that administration of anti-HMGB1 might attenuate dry eyes by modulating ILCs in mouse model of Sjögren syndrome. This study was conducted in conformance with the FASEB Statement of Principles for the use of animals in research and education. 10 weeks-old NOD. B10 or B6 mice had been subconjunctivally injected by 0.02 to 2 ug of anti-HMGB1 antibodies or PBS for 2 weeks. Injection of anti-HMGB1 attenuated corneal epithelial erosions significantly by fluorescein staining and increased tear secretion transiently by phenol-red thread test. After stimulation of the cells from Peyer’s patches or cervical drainage lymph nodes by IL1b and IL23, cells were negatively gated using anti-mouse CD3-PerCP-Cy5.5 and B220-FITC, and were positively gated using anti-mouse CD45-APC-Cy7, NKp46-APC and IL22-PE. The percentages and the numbers of NKp46+IL22 or NKp46-IL22 secreting cells were increased in cervical lymph nodes of anti-HMGB1 injected mice compared with those in PBS injected mice. While, those were not significantly changed in Peyer’s patches of anti-HMGB1 or PBS injected mice. Together, data demonstrate that administration of anti-HMGB1 attenuates dry eyes by increasing IL-22-secreting ILCs in mouse model of Sjögren syndrome.

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Diel, Ryan J., Jodi Hwang, Zachary A. Kroeger, Roy C. Levitt, Constantine D. Sarantopoulos, Heather Sered, Elizabeth R. Felix, Jasmine Martinez-Barrizonte, and Anat Galor. "Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections." British Journal of Ophthalmology 103, no. 8 (September 29, 2018): 1024–29. http://dx.doi.org/10.1136/bjophthalmol-2018-312649.

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BackgroundTo evaluate the efficacy of botulinum toxin A (BoNT-A) in reducing photophobia and dry eye symptoms in individuals with chronic migraine. Additionally, we aimed to evaluate tear film volume as a potential contributor to symptoms in these patients.MethodsRetrospective review of 76 patients who received BoNT-A for chronic migraine between 23 August 2017 and 13 December 2017 at the Miami Veterans Affairs Medical Center Neurotoxin Clinic. Demographic data and all comorbidities were queried via chart review. Standardised validated surveys were administered to assess symptoms prior to and after BoNT-A injection. Preinjection tear volumes were obtained using the phenol red thread (PRT) test.ResultsPreinjection migraine, photophobia and dry eye symptom scores were all significantly correlated, p<0.05, and none were associated with preinjection PRT results. After BoNT-A, improvements in migraine, photophobia and dry eye symptoms were also significantly correlated, p<0.05 and similarly did not associate with preinjection PRT results. Photophobia scores significantly improved following BoNT-A, while dry eye symptoms significantly improved in those with severe symptoms at baseline (DEQ-5 score ≥12), p=0.027. In logistic regression analysis of all individuals with dry eye symptoms (DEQ-5 ≥6), individuals with more severe dry eye symptoms were more likely improve, OR 1.27, 95% CI 1.06 to 1.51, p<0.01.ConclusionsBoNT-A significantly improved photophobia in patients being treated for migraine and also improved dry eye symptoms in patients with severe symptoms at baseline, independent of baseline tear film volume. These improvements may be due to modulation of shared trigeminal neural pathways.

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STOLLER, KENNETH P., and ROBERT LOSEY. "Inadvertent Intra-arterial Injection of Penicillin: An Unseen Danger." Pediatrics 75, no. 4 (April 1, 1985): 785–86. http://dx.doi.org/10.1542/peds.75.4.785.

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Abstract:

The inadvertent intra-arterial injection of penicillin has been reported in the buttock1-3 and in the thigh.4,5 The resulting lesion in the small arterioles leads to thrombosis and ischemic damage to tissues supplied by them. Schanzer et al5 felt that accidental intra-arterial injections of penicillin were the result of a design flaw in the disposable, ready-to-use containers (Tubex) in which many of the penicillin preparations are supplied. This container consists of a glass tube with a 20-gauge, 3.2-cm needle at one end and a rubber disk (plunger head) with a threaded pin inserted in it at the other. The container is positioned in a metallic or plastic injector in which a plunger is screwed to the threaded pin permitting the contents to be ejected.

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Journal articles on the topic 'Thread injection'

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