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Journal articles on the topic 'Three-delay model high-risk pregnancies'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Milligan, J. E. "Maternal and Child Care: The Canadian Model." Acta geneticae medicae et gemellologiae: twin research 43, no. 1-2 (1994): 45–51. http://dx.doi.org/10.1017/s0001566000002944.

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A sophisticated regionalization plan in maternal and child care, including risk assessment, maternal transfer mechanisms, 24 hour communication availability, and regional tertiary perinatal intensive care units (high risk obstetrics integrated with level III neonatal intensive care), has allowed the Province of Ontario to significantly decrease perinatal mortality. Data collection by hospital of birth, birthweight and gestational age shows that this effect is most marked in the preterm infant between 25 and 32 weeks and in hospitals with small obstetrical volumes. Little decrease in incidence

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Azinar, Muhammad, Arulita Ika Fibriana, Anik Setyo Wahyuningsih, and Mahalul Azam. "Precede-Procede Analysis of Prenatal Class Plus Model in the Optimization Education of High Risk Pregnancy." Jurnal Kesehatan Masyarakat 14, no. 1 (2018): 10–19. http://dx.doi.org/10.15294/kemas.v14i1.11532.

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High-risk pregnancies are still common in rural areas. The percentage of high-risk pregnancy in Singorojo sub-district of Kendal District in the last three years has increased significantly. The highest number of cases was in Cening and Singorojo villages. In the past year, 86.88% of pregnancies in Cening village and 55.42% of pregnancies in Singorojo village were categorized as high-risk. The lack in community education limited prevention of high-risk pregnancies. Prenatal Class Plus model is an innovation that was being developed in this study. This is a research and development study with q

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Rebecca, S. Dela Cruz. "Determinants of maternal mortality in Cagayan Valley Philippines." Journal of Biodiversity and Environmental Sciences (JBES) 24, no. 2 (2024): 81–107. https://doi.org/10.5281/zenodo.14183982.

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Maternal mortality is one of the country’s general health status indicators. This highly preventable phenomenon has been a long-time global health issue that remains high despite the various maternal health initiatives implemented in the country. With the unmet MMR target, this is reasonably included as one primary focus in Sustainable Development Goal No. 3 (SDG3) that focuses on the reduction of maternal mortality. The study aimed to explore the determinants of maternal mortality in Cagayan Valley, Philippines, for the past five years. The researchers used a convergent parallel mixed-m

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Shamshuzzoha, Md, and Md Motaharul Islam. "Early Prediction Model of Macrosomia Using Machine Learning for Clinical Decision Support." Diagnostics 13, no. 17 (2023): 2754. http://dx.doi.org/10.3390/diagnostics13172754.

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The condition of fetal overgrowth, also known as macrosomia, can cause serious health complications for both the mother and the infant. It is crucial to identify high-risk macrosomia-relevant pregnancies and intervene appropriately. Despite this need, there are several gaps in research related to macrosomia, including limited predictive models, insufficient machine learning applications, ineffective interventions, and inadequate understanding of how to integrate machine learning models into clinical decision-making. To address these gaps, we developed a machine learning-based model that uses m

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Westergaard, Hanne Brix, Jan Sørensen, and Jens Langhoff-Roos. "ILLUSTRATIVE ESTIMATES OF COSTS AND EFFECTS OF THE USE OF DOPPLER ULTRASONOGRAPHY IN HIGH-RISK PREGNANCIES." International Journal of Technology Assessment in Health Care 19, no. 4 (2003): 624–31. http://dx.doi.org/10.1017/s0266462303000588.

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Objectives: To examine the cost-effectiveness of Doppler ultrasonography in high-risk pregnancies.Methods: An analysis was made of the cost-effectiveness of Doppler ultrasonography in high-risk pregnancies in relation to different organizational models. National costs of Doppler ultrasonography for singleton pregnancies with intrauterine growth retardation were estimated for three models. The cost-effectiveness analysis was based on results from a meta-analysis on clinical effects, patient costs, immediate health care costs, and costs per “saved” perinatal death.Results: In the decentralized m

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Martin-Alonso, Raquel, Valeria Rolle, Ranjit Akolekar, et al. "Efficiency of the Cerebroplacental Ratio in Identifying High-Risk Late-Term Pregnancies." Medicina 59, no. 9 (2023): 1670. http://dx.doi.org/10.3390/medicina59091670.

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Background and Objectives: Over the last few years, great interest has arisen in the role of the cerebroplacental ratio (CPR) to identify low-risk pregnancies at higher risk of adverse pregnancy outcomes. This study aimed to assess the predictive capacity of the CPR for adverse perinatal outcomes in all uncomplicated singleton pregnancies attending an appointment at 40–42 weeks. Materials and Methods: This is a retrospective cohort study including all consecutive singleton pregnancies undergoing a routine prenatal care appointment after 40 weeks in three maternity units in Spain and the United

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Deldar, Kolsoum, Seyed Mahmood Tara, and Majid Jangi. "Systematic extraction of diagnostic data items for common high-risk pregnancies using Delphi technique." Medical Technologies Journal 1, no. 4 (2017): 119. http://dx.doi.org/10.26415/2572-004x-vol1iss4p119-119.

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Introduction The quality of clinical decisions being made every day by on-call physicians are totally based on the quality of medical information they receive during telephone consultations with residents. Some basic factors such as the right selection of medical items, type and format, and also the volume of such information may highly affect the quality of remote consultations. Therefore, developing a trusted standard model for such clinical communication seems vital. In this research, we used Delphi technique to develop a set of information items in form of clinical decision archetype

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Cavallaro, Francesca L., Diane Duclos, Jenny A. Cresswell, et al. "Understanding ‘missed appointments’ for pills and injectables: a mixed methods study in Senegal." BMJ Global Health 3, no. 6 (2018): e000975. http://dx.doi.org/10.1136/bmjgh-2018-000975.

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IntroductionHigh discontinuation rates of contraceptive methods have been documented in sub-Saharan Africa. However, little is known about gaps within individual episodes of method use, despite their implications for unintended pregnancies. The objective of this mixed methods study was to examine the prevalence of, and explore the factors contributing to, delays in repeat appointments for pills and injectables in Senegal.MethodsFirst, we constructed a longitudinal data set of women’s contraceptive consultations using routine records from 67 facilities in Senegal. Consultations for pills and in

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Plant, Nicola, Dana Šumilo, Rachel Chapman, Jonathan Webber, Ponnusamy Saravanan, and Krishnarajah Nirantharakumar. "Unmet needs of women with GDM: a health needs assessment in Sandwell, West Midlands." Journal of Public Health 42, no. 4 (2019): e516-e524. http://dx.doi.org/10.1093/pubmed/fdz172.

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ABSTRACT Background Gestational diabetes mellitus (GDM) affects over 4% of pregnancies in England. We investigated GDM epidemiology within ethnically diverse population and the current offer of services to women with previous GDM to reduce their type 2 diabetes mellitus (T2DM) risk. Methods (i) Analysis of routinely collected maternity data examining GDM incidence and risk factors; (ii) local authority self-assessment questionnaire on public health interventions targeting women with previous GDM and (iii) service development discussions regarding the current pathway and areas for improvement.

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Afolabi, Adebukunola Olajumoke, Adenike Ayobola Olaogun, Kolade Afolayan Afolabi, and Esther Kikelomo Afolabi. "Determinants of unintended pregnancies among nursing mothers in southwest Nigeria." African Journal of Midwifery and Women's Health 14, no. 2 (2020): 1–17. http://dx.doi.org/10.12968/ajmw.2019.0010.

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Background/aims Studies have identified risks for unintended pregnancies, globally and in Nigeria, which include ineffective contraception, strong opposition to family planning by partners, number of living children and birth interval. These factors have contributed to the increasing rate of unintended pregnancy and the high rate of induced abortion, with associated consequences such as obstetric haemorrhage, infection and increased maternal morbidity and mortality. However, there is a paucity of information regarding the influence of culture and religion on pregnancy intentions. This study ai

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Cooray, Shamil D., Jacqueline A. Boyle, Georgia Soldatos, et al. "Protocol for development and validation of a clinical prediction model for adverse pregnancy outcomes in women with gestational diabetes." BMJ Open 10, no. 11 (2020): e038845. http://dx.doi.org/10.1136/bmjopen-2020-038845.

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IntroductionGestational diabetes (GDM) is a common yet highly heterogeneous condition. The ability to calculate the absolute risk of adverse pregnancy outcomes for an individual woman with GDM would allow preventative and therapeutic interventions to be delivered to women at high-risk, sparing women at low-risk from unnecessary care. The Prediction for Risk-Stratified care for women with GDM (PeRSonal GDM) study will develop, validate and evaluate the clinical utility of a prediction model for adverse pregnancy outcomes in women with GDM.Methods and analysisWe undertook formative research to c

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Allotey, John, Lucinda Archer, Kym I. E. Snell, et al. "Development and validation of a prognostic model to predict birth weight: individual participant data meta-analysis." BMJ Medicine 3, no. 1 (2024): e000784. http://dx.doi.org/10.1136/bmjmed-2023-000784.

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ObjectiveTo predict birth weight at various potential gestational ages of delivery based on data routinely available at the first antenatal visit.DesignIndividual participant data meta-analysis.Data sourcesIndividual participant data of four cohorts (237 228 pregnancies) from the International Prediction of Pregnancy Complications (IPPIC) network dataset.Eligibility criteria for selecting studiesStudies in the IPPIC network were identified by searching major databases for studies reporting risk factors for adverse pregnancy outcomes, such as pre-eclampsia, fetal growth restriction, and stillbi

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Kagoye, Sophia Adam, Ola Jahanpour, Octavian Aron Ngoda, Joseph Obure, Michael Johnson Mahande, and Jenny Renju. "Trends and determinants of unmet need for modern contraception among adolescent girls and young women in Tanzania, 2004–2016." PLOS Global Public Health 4, no. 1 (2024): e0000695. http://dx.doi.org/10.1371/journal.pgph.0000695.

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Unintended pregnancy at a young age can lead to poor reproductive health, social and economic outcomes. The high rate of unintended teenage pregnancies in Tanzania is indicative of inadequate availability and uptake of modern contraception. Determining trends and determinants of unmet need for modern contraception among adolescent girls and young women (AGYW) in Tanzania will help address the burden of unintended pregnancies. An analytical cross-sectional study design was conducted using secondary data from three consecutive Tanzania Demographic and Health Surveys (TDHS) 2004/05, 2010 and 2015

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Orlanes, Jessyl D., and Kennet G. Cuarteros. "Significant Factors in Using Contraceptives among Married Women in Cagayan de Oro City using Binary Logistic Regression." Canadian Journal of Family and Youth / Le Journal Canadien de Famille et de la Jeunesse 12, no. 1 (2019): 200–224. http://dx.doi.org/10.29173/cjfy29498.

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Family planning is a larger concept involving preparation and knowledge around a “family future”. It allows people to attain their desired number of children and determine the spacing of pregnancies, reduces the need for abortion, especially unsafe abortion. On the other hand, contraceptives are the group of methods you use or steps you take to avoid pregnancy before you are ready. Contraceptives, one of the methods of family planning, helps prevent the transmission of other sexually transmitted infections. Moreover, it can help slow down population growth thereby contributing to economic bene

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Schabel, Matthias C., Victoria H. J. Roberts, Karen J. Gibbins, et al. "Quantitative longitudinal T2* mapping for assessing placental function and association with adverse pregnancy outcomes across gestation." PLOS ONE 17, no. 7 (2022): e0270360. http://dx.doi.org/10.1371/journal.pone.0270360.

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Existing methods for evaluating in vivo placental function fail to reliably detect pregnancies at-risk for adverse outcomes prior to maternal and/or fetal morbidity. Here we report the results of a prospective dual-site longitudinal clinical study of quantitative placental T2* as measured by blood oxygen-level dependent magnetic resonance imaging (BOLD-MRI). The objectives of this study were: 1) to quantify placental T2* at multiple time points across gestation, and its consistency across sites, and 2) to investigate the association between placental T2* and adverse outcomes. 797 successful im

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Pietersma, C. S., A. G. M. G. J. Mulders, A. Sabanovic, et al. "The impact of maternal smoking on embryonic morphological development: the Rotterdam Periconception Cohort." Human Reproduction 37, no. 4 (2022): 696–707. http://dx.doi.org/10.1093/humrep/deac018.

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Abstract STUDY QUESTION Is periconceptional maternal smoking associated with embryonic morphological development in ongoing pregnancies? SUMMARY ANSWER Smoking during the periconceptional period is associated with a delayed embryonic morphological development which is not fully recuperated beyond the first trimester of pregnancy. WHAT IS KNOWN ALREADY Smoking during pregnancy decreases prenatal growth, increasing the risk of preterm birth, small for gestational age (GA) and childhood obesity. STUDY DESIGN, SIZE, DURATION Between 2010 and 2018, 689 women with ongoing singleton pregnancies were

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Youssef, Angelos, Marie-Louise van der Hoorn, Rik van Eekelen, et al. "Development of the OPAL prediction model for prediction of live birth in couples with recurrent pregnancy loss: protocol for a prospective and retrospective cohort study in the Netherlands." BMJ Open 12, no. 9 (2022): e062402. http://dx.doi.org/10.1136/bmjopen-2022-062402.

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IntroductionRecurrent pregnancy loss (RPL) is defined as the loss of two or more conceptions before 24 weeks gestation. Despite extensive diagnostic workup, in only 25%–40% an underlying cause is identified. Several factors may increase the risk for miscarriage, but the chance of a successful pregnancy is still high. Prognostic counselling plays a significant role in supportive care. The main limitation in current prediction models is the lack of a sufficiently large cohort, adjustment for relevant risk factors, and separation between cumulative live birth rate and the success chance in the ne

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Costa, Fernanda P., Ana C. Simões e Silva, Robert H. Mak, et al. "A clinical predictive model of renal injury in children with isolated antenatal hydronephrosis." Clinical Kidney Journal 13, no. 5 (2019): 834–41. http://dx.doi.org/10.1093/ckj/sfz102.

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Abstract Background Antenatal hydronephrosis (ANH) affects ∼1–5% of pregnancies. The aim of this study was to develop a clinical prediction model of renal injury in a large cohort of infants with isolated ANH. Methods This is a longitudinal cohort study of 447 infants with ANH admitted since birth between 1989 and 2015 at a tertiary care center. The primary endpoint was time until the occurrence of a composite event of renal injury, which includes proteinuria, hypertension and chronic kidney disease (CKD). A predictive model was developed using a Cox proportional hazards model and evaluated by

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Li, Jinke, Dandan Zhang, Hong Lin, et al. "Postpartum haemorrhage following vaginal delivery: a comprehensive analysis and development of predictive models for aetiological subgroups in Chinese women." BMJ Open 15, no. 1 (2025): e089734. https://doi.org/10.1136/bmjopen-2024-089734.

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ObjectivesThis study aimed to dissect the aetiological subgroups of postpartum haemorrhage (PPH) that occur after vaginal delivery in women with full-term singleton pregnancies. Our goal was to craft and validate predictive models to guide clinical decision-making and optimise resource allocation.DesignA retrospective cohort study.SettingShengjing Hospital of China Medical University, Liaoning Maternal and Child Health Hospital, and Shenyang Women’s and Children’s Hospital.Participants29 842 women who underwent vaginal delivery were enrolled in the study across three hospitals from 2016 to 202

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Guo, Zhiwei, Ke Wang, Xiang Huang, et al. "Genome-wide nucleosome footprints of plasma cfDNA predict preterm birth: A case-control study." PLOS Medicine 22, no. 4 (2025): e1004571. https://doi.org/10.1371/journal.pmed.1004571.

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Background Preterm birth (PTB) occurs in approximately 11% of all births worldwide, resulting in significant morbidity and mortality for both mothers and their offspring. Identifying pregnancies at risk of preterm birth during early pregnancy may help improve interventions and reduce its incidence. Plasma cell-free DNA (cfDNA), derived from placenta and other maternal tissues, serves as a dynamic indicator of biological processes and pathological changes in pregnancy. These properties establish cfDNA as a valuable biomarker for investigating pregnancy complications, including PTB. Methods and

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Harachka, A. N., and A. V. Sukalo. "Prognostic model for determining the probability of developing congenital pneumonia in preterm infants with low body weight." Proceedings of the National Academy of Sciences of Belarus, Medical series 18, no. 2 (2021): 228–33. http://dx.doi.org/10.29235/1814-6023-2021-18-2-228-233.

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The aim of the study was to create a prognostic model for determining the probability of developing congenital pneumonia in preterm infants with low body weight.108 preterm infants with low body weight who were in the department of anesthesiology and resuscitation (with wards for newborns) and the pediatric department for preterm infants were examined.A comparative analysis of 214 life history data, outcomes of previous pregnancies, complications of present pregnancy in mothers, clinical and laboratory methods of study in newborns in the first three days of life was carried out. Later, the mos

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Arkorful, Joseph, Joyce Linda Browne, Kwame Adu-Bonsaffoh, Sam Ali, Emmanuel Srofenyoh, and Kitty M. W. Bloemenkamp. "Predictive accuracy of ophthalmic artery Doppler for pre-eclampsia: a systematic review." BMJ Open 15, no. 6 (2025): e094348. https://doi.org/10.1136/bmjopen-2024-094348.

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Objectives This systematic review investigated available evidence on the stand-alone and incremental predictive performance of ophthalmic artery Doppler (OAD) for pre-eclampsia. Design Systematic review. Data sources We conducted a literature search from PubMed (Medline), the Cochrane CENTRAL, EMBASE and Scopus from inception to 8 April 2025. Eligibility criteria Studies eligible for inclusion were prospective or retrospective cohort studies, case-control studies or randomised controlled trials that reported on the predictive performance of OAD for pre-eclampsia in singleton pregnancies; and c

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Liu, Jiao, Lixia Shen, Long Nguyen-Hoang, et al. "Aspirin versus metformin in pregnancies at high risk of preterm pre-eclampsia in China (AVERT): protocol for a multicentre, double-blind, 3-arm randomised controlled trial." BMJ Open 14, no. 4 (2024): e074493. http://dx.doi.org/10.1136/bmjopen-2023-074493.

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IntroductionPre-eclampsia (PE) affects about 5% of Chinese pregnant women and is a major cause of maternal and perinatal morbidity and mortality. The first trimester screening model developed by the Fetal Medicine Foundation, which uses the Bayes theorem to combine maternal characteristics and medical history together with measurements of biomarkers, has been proven to be effective and has superior screening performance to that of the traditional risk factor-based approach for the prediction of PE. Prophylactic use of low-dose aspirin in women at risk for PE has resulted in a lower incidence o

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Ngoda, Octavian Aron, Jenny Renju, Michael Johnson Mahande, Sophia Adam Kagoye, Innocent Baltazar Mboya, and Sia Emmanueli Msuya. "Trends and Factors Associated with Adolescent Pregnancies in Tanzania from 2004-2016: Evidence from Tanzania Demographic and Health Surveys." East African Health Research Journal 7, no. 1 (2023): 40–48. http://dx.doi.org/10.24248/eahrj.v7i1.707.

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Background: Adolescent pregnancy increases the risk of maternal and child morbidity and mortality. We aimed to determine trends and factors associated with adolescent pregnancy in Tanzania from 2004 to 2016 using the Tanzania Demographic and Health surveys (TDHS). Methods: We carried out an analytical cross-sectional study using the TDHS data for the years 2004 to 2005, 2010 and 2015 to 2016 among adolescent girls aged 15 to 19 years. Data analysis was performed using STATA version 15. Data analysis considered the complex survey design inherent in the demographic and health survey (DHS) data.

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Li, Qiangqiang, Konstantinos Dimopoulos, Tianyang Liu, et al. "Peripartum outcomes in a large population of women with pulmonary arterial hypertension associated with congenital heart disease." European Journal of Preventive Cardiology 26, no. 10 (2019): 1067–76. http://dx.doi.org/10.1177/2047487318821246.

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Aims Pulmonary arterial hypertension is a severe complication in patients with congenital heart disease and poses a significant risk to women wishing to become pregnant. This study describes the clinical presentation, maternal outcomes and risk factors for the peripartum period in women with pulmonary arterial hypertension related to congenital heart disease (PAH-CHD). Methods All pregnant women with PAH-CHD who were admitted for delivery in a tertiary center between February 2011–September 2016 were included. Logistic regression analysis was used to identify predictors of the combined endpoin

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Anakwe, Adaobi, Rhonda BeLue, Hong Xian, and Pamela Xaverius. "Men’s Preconception Health and Fertility Intentions: A Latent Class Analysis Approach." American Journal of Men's Health 16, no. 6 (2022): 155798832211357. http://dx.doi.org/10.1177/15579883221135764.

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Men’s pregnancy intention is associated with a host of positive outcomes for families, yet this topic remains understudied. Because unintended pregnancies are more likely to occur at suboptimal parental health, this study aimed to examine the extent to which men improve their preconception health in the context of future fertility planning. This study used pooled data from the 2011–2019 National Survey of Family Growth for a final sample size of 10,223. Latent class analysis (LCA) was used to identify distinct classes of men’s preconception health. Eight preconception health risk factors were

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Greene, Nicholas D. E., Kit-Yi Leung, Victoria Gay, et al. "Inositol for the prevention of neural tube defects: a pilot randomised controlled trial." British Journal of Nutrition 115, no. 6 (2016): 974–83. http://dx.doi.org/10.1017/s0007114515005322.

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AbstractAlthough peri-conceptional folic acid (FA) supplementation can prevent a proportion of neural tube defects (NTD), there is increasing evidence that many NTD are FA non-responsive. The vitamin-like molecule inositol may offer a novel approach to preventing FA-non-responsive NTD. Inositol prevented NTD in a genetic mouse model, and was well tolerated by women in a small study of NTD recurrence. In the present study, we report the Prevention of Neural Tube Defects by Inositol (PONTI) pilot study designed to gain further experience of inositol usage in human pregnancy as a preliminary tria

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Trilla, Cristina, Josefina Mora, Nuria Ginjaume, et al. "Reduction in Preterm Preeclampsia after Contingent First-Trimester Screening and Aspirin Prophylaxis in a Routine Care Setting." Diagnostics 12, no. 8 (2022): 1814. http://dx.doi.org/10.3390/diagnostics12081814.

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Objectives: Several multivariate algorithms for preeclampsia (PE) screening in the first trimester have been developed over the past few years. These models include maternal factors, mean arterial pressure (MAP), uterine artery Doppler (UtA-PI), and biochemical markers (pregnancy-associated plasma protein-A (PAPP-A) or placental growth factor (PlGF)). Treatment with low-dose aspirin (LDA) has shown a reduction in the incidence of preterm PE in women with a high-risk assessment in the first trimester. An important barrier to the implementation of first-trimester screening is the cost of perform

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Kay, Vanessa R., Matthew T. Rätsep, Lindsay S. Cahill, et al. "Effects of placental growth factor deficiency on behavior, neuroanatomy, and cerebrovasculature of mice." Physiological Genomics 50, no. 10 (2018): 862–75. http://dx.doi.org/10.1152/physiolgenomics.00076.2018.

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Preeclampsia, a hypertensive syndrome occurring in 3–5% of human pregnancies, has lifelong health consequences for fetuses. Cognitive ability throughout life is altered, and adult stroke risk is increased. One potential etiological factor for altered brain development is low concentrations of proangiogenic placental growth factor (PGF). Impaired PGF production may promote an antiangiogenic fetal environment during neural and cerebrovascular development. We previously reported delayed vascularization of the hindbrain, altered retinal vascular organization, and less connectivity in the circle of

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Weiner, Carl Philip, Howard Cuckle, Mark Louis Weiss, et al. "Evaluation of a Maternal Plasma RNA Panel Predicting Spontaneous Preterm Birth and Its Expansion to the Prediction of Preeclampsia." Diagnostics 12, no. 6 (2022): 1327. http://dx.doi.org/10.3390/diagnostics12061327.

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Preterm birth is the principal contributor to neonatal death and morbidity worldwide. We previously described a plasma cell-free RNA panel that between 16 and 20 weeks of pregnancy had potential to predict spontaneous preterm birth (sPTB) ≤ 32 weeks caused by preterm labor (PTL) or preterm premature rupture of membranes (PPROM). The present study had three objectives: (1) estimate the RNA panel prognostic accuracy for PTL/PPROM ≤ 32 weeks in a larger series; (2) improve accuracy by adding clinical characteristics to the predictive model; and (3) examine the association of the RNA panel with pr

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Zeidan, Aya Mutaz, Paula Ramirez Gilliland, Ashay Patel, et al. "An Approach to Automated Diagnosis and Texture Analysis of the Fetal Liver & Placenta in Fetal Growth Restriction." Machine Learning for Biomedical Imaging 1, PIPPI 2021 (2023): 1–37. http://dx.doi.org/10.59275/j.melba.2022-ac28.

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Fetal growth restriction (FGR) is a prevalent pregnancy condition characterised by failure of the fetus to reach its genetically predetermined growth potential. The multiple aetiologies, coupled with the risk of fetal complications - encompassing neurodevelopmental delay, neonatal morbidity, and stillbirth - motivate the need to improve holistic assessment of the FGR fetus using MRI. We hypothesised that the fetal liver and placenta would provide insights into FGR biomarkers, unattainable through conventional methods. Therefore, we explore the application of model fitting techniques, linear re

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Sedlecki, Katarina. "Behavior and attitudes of adolescents relevant to their reproductive health." Stanovnistvo 39, no. 1-4 (2001): 91–117. http://dx.doi.org/10.2298/stnv0104091s.

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Increase in adolescent sexual activity is a phenomenon noticed in modern societies, as well as in Serbia. The sexual activity reveals new health related problems, in relation to the unpremeditated pregnancies and sexually transmitted diseases. Reproductive health is vulnerable especially in case of persons having first sexual experiences being adolescent, what could be explained by the physical immaturity and psychosocial infirmity to be responsible in sexual behaviour. The study of 300 sexually active adolescent women aged 19, attending The Youth Advisory Center of The Mother and Child Health

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Bennett, Rachel, Zuber D. Mulla, Pavan Parikh, Alisse Hauspurg, and Talayeh Razzaghi. "An imbalance-aware deep neural network for early prediction of preeclampsia." PLOS ONE 17, no. 4 (2022): e0266042. http://dx.doi.org/10.1371/journal.pone.0266042.

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Preeclampsia (PE) is a hypertensive complication affecting 8-10% of US pregnancies annually. While there is no cure for PE, aspirin may reduce complications for those at high risk for PE. Furthermore, PE disproportionately affects racial minorities, with a higher burden of morbidity and mortality. Previous studies have shown early prediction of PE would allow for prevention. We approached the prediction of PE using a new method based on a cost-sensitive deep neural network (CSDNN) by considering the severe imbalance and sparse nature of the data, as well as racial disparities. We validated our

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McBride, Nancy, Paul Yousefi, Ulla Sovio, et al. "Do Mass Spectrometry-Derived Metabolomics Improve the Prediction of Pregnancy-Related Disorders? Findings from a UK Birth Cohort with Independent Validation." Metabolites 11, no. 8 (2021): 530. http://dx.doi.org/10.3390/metabo11080530.

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Many women who experience gestational diabetes (GDM), gestational hypertension (GHT), pre-eclampsia (PE), have a spontaneous preterm birth (sPTB) or have an offspring born small/large for gestational age (SGA/LGA) do not meet the criteria for high-risk pregnancies based upon certain maternal risk factors. Tools that better predict these outcomes are needed to tailor antenatal care to risk. Recent studies have suggested that metabolomics may improve the prediction of these pregnancy-related disorders. These have largely been based on targeted platforms or focused on a single pregnancy outcome.

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Danhof, N. A., R. Wang, M. van Wely, F. van der Veen, B. W. J. Mol, and M. H. Mochtar. "IUI for unexplained infertility—a network meta-analysis." Human Reproduction Update 26, no. 1 (2019): 1–15. http://dx.doi.org/10.1093/humupd/dmz035.

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ABSTRACT BACKGROUND IUI for unexplained infertility can be performed in a natural cycle or in combination with ovarian stimulation. A disadvantage of ovarian stimulation is an increased risk of multiple pregnancies with its inherent maternal and neonatal complication risks. Stimulation agents for ovarian stimulation are clomiphene citrate (CC), Letrozole or gonadotrophins. Although studies have compared two or three of these drugs to each other in IUI, they have never been compared to one another in one analysis. OBJECTIVE AND RATIONALE The objective of this network meta-analysis was to compar

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Harachka, A. N., and A. V. Sukalo. "Express method for determining the probability of developing congenital pneumonia in preterm infants with low body weight." CHILD`S HEALTH 16, no. 3 (2021): 233–38. http://dx.doi.org/10.22141/2224-0551.16.3.2021.233908.

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Background. According to the World Health Organization, more than 2 million children under the age of five die from pneumonia every year, accounting for almost 1 in 5 deaths. Therefore, the aim of the study was to develop a mathematical model for determining the probability of developing congenital pneumonia in premature infants with low body weight by the express method. Materials and methods. A comprehensive examination of 171 newborns who stayed at the maternity physiology department, the department of anesthesiology and resuscitation (with wards for newborns) and the pediatric department f

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Corbett, Gillian, Mandy Daly, Dylan Keegan, et al. "Embedding the patient voice into research on spontaneous preterm birth—themes from a Preterm Birth Advisory Council." PLOS ONE 19, no. 12 (2024): e0312370. https://doi.org/10.1371/journal.pone.0312370.

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Background Spontaneous preterm birth (sPTB) has a deep immediate impact on patients but also alters their care and experience in subsequent pregnancies. There is an absence of the pregnant patient’s voice in the research surrounding pregnancy at risk of sPTB. Materials/methods The Preterm Birth Advisory Council was established at the National Maternity Hospital (NMH) in January 2023, to introduce and embed the patient voice in research into sPTB prevention. Council members include patients with lived experience of sPTB, patient advocate representatives and clinicians involved in sPTB preventat

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Muresan, Maria Cezara, Biliana Belovan, Ioan Sîrbu, et al. "Dynamic Lipid–Glycaemic Index and Inflammation—Endothelial Shifts and Fetal Aortic Wall Thickening: A Repeated-Measures Gestational Phenotyping Study." Medicina 61, no. 6 (2025): 964. https://doi.org/10.3390/medicina61060964.

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Background and Objectives: Maternal dyslipidaemia and low-grade inflammation are recognised drivers of in utero vascular remodelling, yet composite dynamic markers that integrate lipid–glycaemic, inflammatory and endothelial signals have not been evaluated. We investigated whether eight-week trajectories in the triglyceride–glucose index (TyG), interleukin-6 (IL-6) and flow-mediated dilation (FMD) outperform single-timepoint lipids for predicting fetal aortic remodelling. Materials and Methods: In a prospective repeated-measures study, 90 singleton pregnancies were examined at 24–26 weeks (Vis

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Горячко, А. Н., А. В. Сукало, and Т. П. Павлович. "Model for Determining the Probability of Congenital Pneumonia in Premature Newborns with Very Low and Extremely Low Birth Weight." Педиатрия. Восточная Европа, no. 3 (November 3, 2022): 351–57. http://dx.doi.org/10.34883/pi.2022.10.3.006.

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Цель. Разработать математическую модель для определения вероятности развития врожденной пневмонии у недоношенных новорожденных с очень низкой и экстремально низкой массой тела.Материалы и методы. Обследовано 168 недоношенных новорожденных, находившихся в отделении анестезиологии и реанимации и педиатрическом отделении для недоношенных новорожденных.Результаты. Проведен сравнительный анализ 214 факторов анамнеза жизни, исходов предыдущих беременностей, осложнений настоящей беременности, результатов клинических и лабораторных методов исследования у новорожденных в первые трое суток жизни. По рез

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Ahenkorah, Benjamin, Samuel Asamoah Sakyi, Gideon Helegbe, et al. "Foeto-maternal complications associated with low birth weight: A prospective multicenter study in northern Ghana." PLOS ONE 17, no. 4 (2022): e0266796. http://dx.doi.org/10.1371/journal.pone.0266796.

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Objective The study evaluated the socio-demographic characteristics, obstetric variables and foeto-maternal complications associated with low birth weight (LBW) in order to provide better treatment and management options. Methods The prospective study conducted from February, 2019 to June, 2020 recruited 312 primigravid pregnant women who reported for antenatal care in three tertiary referral hospitals in northern Ghana. Their socio-demographic, obstetric and adverse foeto-maternal outcome information were obtained with a well-structured questionnaire according to the World Health Organisation

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Proto, Alice, Fabienne Trottmann, Sophie Schneider, et al. "First Trimester Contingent Screening for Aneuploidies with Cell-Free Fetal DNA in Singleton Pregnancies – a Swiss Single Centre Experience." Geburtshilfe und Frauenheilkunde 84, no. 01 (2024): 68–76. http://dx.doi.org/10.1055/a-2202-5282.

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AbstractSwitzerland was amongst the first countries to offer cell-free fetal DNA (cffDNA) testing covered by the health insurance to pregnant women with a risk ≥ 1:1000 for trisomies at first trimester combined screening (FTCS). The aim of this study is to evaluate the implementation of this contingent model in a single tertiary referral centre and its effect on gestational age at diagnosing trisomy 21.Between July 2015 and December 2020 all singleton pregnancies at 11–14 weeks of gestation without major fetal malformation were included and stratified according to their risk at FTCS. Statistic

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Arantes, Adriano Moraes, Gerdine Sanson, Amador Gonçalves Primo, et al. "Early Prediction of Acute Gvhd Based on Molecular Profiling at the Time of Engraftment after Hematopoietic Stem Cell Transplantation." Blood 112, no. 11 (2008): 2233. http://dx.doi.org/10.1182/blood.v112.11.2233.2233.

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Abstract Allogeneic hematopoietic stem cell transplantation is an important last resort therapy for hematological diseases. Unfortunately, the success of a large proportion of these transplants is limited by graft-versus-host disease (GVHD). Currently known risk factors for acute GVHD (histoincompatibility, sex mismatch, older patients, previous pregnancies) do not provide a precise estimate of individual patient risk and do not help for individualization of the therapy. Although GVHD may have beneficial graft-versus-tumor effects, observational studies have identified GVHD as the main cause o

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Youssef, A., M. L. P. van der Hoorn, M. Dongen, et al. "External validation of a frequently used prediction model for ongoing pregnancy in couples with unexplained recurrent pregnancy loss." Human Reproduction 37, no. 3 (2021): 393–99. http://dx.doi.org/10.1093/humrep/deab264.

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Abstract STUDY QUESTION What is the predictive performance of a currently recommended prediction model in an external Dutch cohort of couples with unexplained recurrent pregnancy loss (RPL)? SUMMARY ANSWER The model shows poor predictive performance on a new population; it overestimates, predicts too extremely and has a poor discriminative ability. WHAT IS KNOWN ALREADY In 50–75% of couples with RPL, no risk factor or cause can be determined and RPL remains unexplained. Clinical management in RPL is primarily focused on providing supportive care, in which counselling on prognosis is a main pil

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Basnet, Tulasa, Sarita Sitaula, Manoj Kumar Sah, and Punita Yadav. "Analysis of Causes and Contributory Factors for Maternal Mortality during Covid-19 Lockdown." International Research Journal of Multidisciplinary Scope 03, no. 02 (2022): 22–28. http://dx.doi.org/10.47857/irjms.2022.v03i02.075.

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Background: Covid-19 pandemic affected maternal health directly by causing respiratory disease in pregnant women as well as indirectly by affecting health care delivery and caused sharp increase in maternal mortality. Aim: This study aimed to assess causes and contributing factors for maternal mortality during six months of Covid-19 lockdown. Methodology: This was a retrospective review of all maternal mortalities over the period of six months (23rd March - 22nd September 2020) after implementation of lockdown. Information regarding demographic variables, obstetric characteristics, referral, d

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Moon, Joon Ho, Joonyub Lee, Kyun Hoo Kim та ін. "Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells". Experimental & Molecular Medicine 55, № 10 (2023): 2269–80. http://dx.doi.org/10.1038/s12276-023-01100-2.

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AbstractPregnancy imposes a substantial metabolic burden on women, but little is known about whether or how multiple pregnancies increase the risk of maternal postpartum diabetes. In this study, we assessed the metabolic impact of multiple pregnancies in humans and in a rodent model. Mice that underwent multiple pregnancies had increased adiposity, but their glucose tolerance was initially improved compared to those of age-matched virgin mice. Later, however, insulin resistance developed over time, but insulin secretory function and compensatory pancreatic β cell proliferation were impaired in

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van Smoorenburg, Sam, Janet M. Kist, Rimke C. Vos, and Hedwig M. M. Vos. "Experiences with an integrated screening programme targeted at women who had a hypertensive disorder or diabetes in pregnancy in the Netherlands: a qualitative study." BMJ Open 13, no. 8 (2023): e066198. http://dx.doi.org/10.1136/bmjopen-2022-066198.

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ObjectivesPregnancy is a predictor of women’s health later in life. The risk of eventually developing cardiovascular disease (CVD) and/or type 2 diabetes (T2D) increases three to seven times, after pre-eclampsia, hypertension gravidarum or gestational diabetes. The Heart for Women in The Hague project was designed to offer targeted screening to this high-risk population. This research aimed to gather insight regarding the initial experiences of healthcare providers and women with pre-eclampsia, hypertension gravidarum or gestational diabetes.Design and settingThis study applied a qualitative s

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AMOAKO JOHNSON, FIIFI, and NYOVANI J. MADISE. "EXAMINING THE GEOGRAPHICAL HETEROGENEITY ASSOCIATED WITH RISK OF MISTIMED AND UNWANTED PREGNANCY IN GHANA." Journal of Biosocial Science 41, no. 2 (2009): 249–67. http://dx.doi.org/10.1017/s0021932008003179.

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SummaryAfter a decade of fertility decline, Ghana’s fertility and the level of unmet need for contraception stalled in mid-transition in the late 1990s. Although the literature acknowledges this, the geographical patterns in unmet need have not been adequately documented. Spatial analysis of unmet need can reveal differences in usage and provision of contraceptive commodities, thereby pointing to geographical areas where contraceptive programmes should be strengthened. This study examines the geographical variation of the risk of mistimed and unwanted pregnancies between rural communities and

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Linask, Kersti K. "The Heart-Placenta Axis in the First Month of Pregnancy: Induction and Prevention of Cardiovascular Birth Defects." Journal of Pregnancy 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/320413.

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Extrapolating from animal studies to human pregnancy, our studies showed that folate (FA) deficiency as well as one-time exposure to environmental factors in the first two to three weeks of human gestation can result in severe congenital heart defects (CHDs). Considering that approximately 49% of pregnancies are unplanned, this period of pregnancy can be considered high-risk for cardiac, as well as for neural, birth defects, as the woman usually is not aware of her pregnancy and may not yet be taking precautionary actions to protect the developing embryo. Using avian and mouse vertebrate model

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Papastefanou, Ioannis, Yunyu Chen, Long Nguyen‐Hoang, et al. "Impact of Aspirin on Timing of Birth in Pregnancies With Clinical Manifestations of Placental Dysfunction: Evidence From a Multicentre Randomised Clinical Trial." BJOG: An International Journal of Obstetrics & Gynaecology, May 14, 2025. https://doi.org/10.1111/1471-0528.18211.

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ABSTRACTObjectiveTo examine whether aspirin delays gestational age at delivery (GAD) in pregnancies with placental dysfunction (PD) phenotypes (preeclampsia [PE], small‐for‐gestational‐age [SGA], placental abruption and/or stillbirth).DesignA secondary analysis of a multicentre stepped‐wedge cluster randomised trial.Setting18 maternity/diagnostic units in Asia.PopulationSingleton pregnancies examined at 11–13+6 weeks.MethodsA model in which the effect of aspirin is to delay the GAD in pregnancies with PD was developed.Main Outcome MeasuresGAD in pregnancies with PD.ResultsAspirin administratio

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Pishghadam, Morteza, Lylach Haizler-Cohen, Julius S. Ngwa, et al. "Placental quantitative susceptibility mapping and T2* characteristics for predicting birth weight in healthy and high-risk pregnancies." European Radiology Experimental 9, no. 1 (2025). https://doi.org/10.1186/s41747-025-00565-2.

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Abstract Background The human placenta is critical in supporting fetal development, and placental dysfunction may compromise maternal-fetal health. Early detection of placental dysfunction remains challenging due to the lack of reliable biomarkers. This study compares placental quantitative susceptibility mapping and T2* values between healthy and high-risk pregnancies and investigates their association with maternal and fetal parameters and their ability to predict birth weight (BW). Methods A total of 105 pregnant individuals were included: 68 healthy controls and 37 high-risk due to fetal g

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