Log in

Relevant bibliographies by topics / Thrombin inhibitor / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Thrombin inhibitor.

Dissertations / Theses on the topic 'Thrombin inhibitor'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Thrombin inhibitor.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Richardson, John Lee. "Structural and kinetic characterization of the leech derived inhibitor haemadin in complex with human [alpha]-thrombin [alpha-thrombin] structural analysis of the tsetse thrombin inhibitor in complex with bovine [alpha]-thrombin [alpha-thrombin] /." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965976335.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Boffa, Michael B. "Structure, function and regulation of TAFI (thrombin-activable fibrinolysis inhibitor)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/NQ54402.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Frère, Corinne. "Thrombin-Activatable Fibrinolysis Inhibitor : étude de la relation génotype-phénotype." Aix Marseille 2, 2006. http://www.theses.fr/2006AIX20695.

Full text

Abstract:

Le Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) est un inhibiteur de la fibrinolyse. Les taux plasmatiques de TAFI Ag présentent une forte variabilité interindividuelle faiblement expliquée par les facteurs environnementaux. Nous avons évalué la contribution des polymorphismes du gène à la variabilité des taux de TAFI Ag. Deux polymorphismes (T+1583A et -2345 2G/1G) ont un effet additif expliquant 25 % de la variabilité des taux. Nous avons ensuite étudié le lien entre polymorphismes du gène du TAFI et risque de maladie coronaire. L’allèle Thr147 est un facteur de risque de survenue d’in

APA, Harvard, Vancouver, ISO, and other styles

4

Antovic, Jovan P. "Thrombin activatable fibrinolysis inhibitor (TAFI) in different hemorrhagic and thrombotic conditions /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-540-9/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Bridge, Katherine Isabella. "The role of thrombin activatable fibrinolysis inhibitor in abdominal aortic aneurysms." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/10749/.

Full text

Abstract:

Thrombin-activatable fibrinolysis inhibitor (TAFI) prevents the breakdown of fibrin clots through its action as an indirect inhibitor of plasmin. Patients with abdominal aortic aneurysms (AAA), in common with a number of cardiovascular diseases, display an altered fibrin clot structure, with denser clots that have smaller pores and an increased resistance to lysis. Murine studies have implicated a potential role for TAFI in AAA disease. This study aimed to investigate the role of TAFI in human AAA, and to complement this with an investigation into the effect of TAFI inhibition on AAA developme

APA, Harvard, Vancouver, ISO, and other styles

6

LIU, YIDAN. "A Novel Method for the Quantitative Evaluation of Fibrinogen Coagulation." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/chemistry_theses/19.

Full text

Abstract:

Fibrinogen aggregation is the last step in blood coagulation. Inhibition of fibrinogen aggregation could lead to anticoagulation effects. However, there is no good method for the ready evaluation of fibrinogen coagulation. A commonly used path method is slow and requires an expensive instrument. In this project, we have developed a microplate reader and In evaluating inhibitors of fibrinogen coagulations there is no good method. As an important process in hemostasis, fibrinogen coagulation is often detected by micro-plate reader. In our test of fibrinogen coagulation, we improved the observing

APA, Harvard, Vancouver, ISO, and other styles

7

Musashi, Kunihoro. "Thrombin inhibitor reduces leukocyte-endothelial cell interactions and vascular leakage after scatter laser photocoagulation." Kyoto University, 2007. http://hdl.handle.net/2433/135742.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Huq, F. Y. "Changes in thrombin activatable fibrinolysis inhibitor and its role in normal pregnancy and pre-eclampsia." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1561635/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Yang, Zhilu, Si Zhong, Ying Yang, et al. "Polydopamine-mediated long-term elution of the direct thrombin inhibitor bivalirudin from TiO₂ nanotubes for improved vascular biocompatibility." Royal Society of Chemistry, 2014. https://tud.qucosa.de/id/qucosa%3A36252.

Full text

Abstract:

Thrombosis and restenosis are two major complications associated with current commercial vascular stents. In situ regeneration of a healthy endothelium has been recognized as a promising strategy to address these issues. Numerous strategies have been explored for this goal. However, in most of the cases, they only focused on enhancing endothelial cell growth, ignoring antithrombotic requirements and the competition between smooth muscle cells (SMCs) and endothelial cells (ECs) for their growth. This resulted in non-satisfying clinical results. In this study, we created a multifunctional surfac

APA, Harvard, Vancouver, ISO, and other styles

10

Guéret, Pierre. "Développement clinique de l'EP217609 et de son antidote l'avidine." Thesis, Brest, 2017. http://www.theses.fr/2017BRES0130.

Full text

Abstract:

Les pentasaccharides sont des inhibiteurs indirects du facteur Xa ayant des profils pharmacocinétiques très prédictibles. En raison de la liaison de forte affinité des pentasaccharides à l'antithrombine, cette pharmacocinétique peut être prédite mais aussi transférée à d'autres molécules qui leur sont liées de manière covalente. L'EP42675 combine dans une seule molécule, une antithrombine directe réversible peptidomimétique (analogue de l'α-NAPAP), et un pentasaccharide inhibiteur indirect du facteur Xa antithrombine dépendant (analogue du fondaparinux). L'EP217609 est le dérivé biotinylé de l

APA, Harvard, Vancouver, ISO, and other styles

11

Mutch, Nicola J. "Thrombin activity in human thrombi and the vessel wall." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340809.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Sun, Wei. "A New Look into Protein C Inhibitor : Posttranslational Modifications and their Functions." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131126.

Full text

Abstract:

The influences of posttranslational modifications on the functions of the versatile serpin protein C inhibitor (PCI) were studied. PCI is a serine protease inhibitor that is expressed in many tissues and secreted to various fluids in human, including blood plasma, seminal plasma, and urine. PCI in blood can act both as an anticoagulant and a procoagulant and is believed to play a role in pathogen defence. PCI in reproductive tissues is believed to regulate human reproduction at several steps, including the fertilization process. Due to the broad protease specificity and the contradictory activ

APA, Harvard, Vancouver, ISO, and other styles

13

Matsson, Elin. "In vivo Pharmacokinetics of Two New Thrombin Inhibitor Prodrugs : Emphasis on Intestinal and Hepatobiliary Disposition and the Influence of Interacting Drugs." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123419.

Full text

Abstract:

Biliary excretion is an important elimination route for many drugs and metabolites. For such compounds, it is important to know the extent of excretion and drug exposure in the bile, e.g., for the risk assessment of drug interactions, liver toxicity and the effects of genetic variants. In this thesis, duodenal aspiration of bile was performed in healthy volunteers and complemented with experiments in an in vivo model in pigs to increase the understanding of the intestinal and hepatobiliary disposition of two direct thrombin inhibitors. The compounds investigated, ximelagatran and AZD0837, are

APA, Harvard, Vancouver, ISO, and other styles

14

Sevilmis, Gueler. "Die Beeinflussung der hyperakuten Abstossungsreaktion der xenogen perfundierten Rattenleber durch den GP IIb/IIIa-Rezeptorblocker GPI 562 und den Thrombin-Inhibitor Hirudin." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-69038.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Glossop, Paul. "Thrombin inhibition." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244533.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Blomberg, David. "Synthesis of β-turn and pyridine based peptidomimetics". Doctoral thesis, Umeå universitet, Kemi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1104.

Full text

Abstract:

Despite the unfavorable pharmacokinetic properties associated with peptides, they are still of great interest in drug development due to a multitude of interesting biological functions. The development of peptidomimetics strives to maintain or improve the biological activity of a peptide concurrently with removing the unwanted properties. This thesis describes two synthetic approaches to peptidomimetics with particular emphasis on secondary structure mimetics. First the design, synthesis and evaluation of two beta-turn mimetics incorporated in the endorphin Leu-enkephalin is presented. The bet

APA, Harvard, Vancouver, ISO, and other styles

17

Nilsson, Jonas. "Design, Synthesis and Characterization of Small Molecule Inhibitors and Small Molecule : Peptide Conjugates as Protein Actors." Doctoral thesis, Linköpings universitet, Organisk Kemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-3943.

Full text

Abstract:

This thesis describes different aspects of protein interactions. Initially the function of peptides and their conjugates with small molecule inhibitors on the surface of Human Carbonic Anhydrase isoenzyme II (HCAII) is evaluated. The affinities for HCAII of the flexible, synthetic helix-loop-helix motif conjugated with a series of spacered inhibitors were measured by fluorescence spectroscopy and found in the best cases to be in the low nM range. Dissociation constants show considerable dependence on linker length and vary from 3000 nM for the shortest spacer to 40 nM for the longest with a mi

APA, Harvard, Vancouver, ISO, and other styles

18

Jumeau, Céline. "La thrombine et son récepteur PAR-1 comme cibles thérapeutiques dans la prévention et le traitement de la dilatation atriale." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066242.

Full text

Abstract:

La fibrillation atriale (FA) est l’arythmie cardiaque la plus fréquente. Elle se caractérise par une contraction désorganisée des oreillettes ainsi que des modifications structurelles du myocarde. La dysfonction endothéliale entretenue par une inflammation active la coagulation et la production de thrombine, favorisant la formation de thrombus intra-auriculaire. La prévention des accidents thromboemboliques est donc un enjeu majeur dans la prise en charge de la FA et se fait par prescription d’anticoagulants oraux dont un inhibiteur direct de thrombine (IDT), le dabigatran. Notre hypothèse est

APA, Harvard, Vancouver, ISO, and other styles

19

Nienaber, Cornelie. "Haemostatic variables in African adolescents : the PLAY study / Cornelie Nienaber." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1322.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Sidhu, Preetpal. "Designing Allosteric Inhibitors of Thrombin." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/295.

Full text

Abstract:

Thrombin is a key enzyme of the coagulation cascade exhibiting important roles in both pro-coagulation and anti-coagulation processes. Most clinically used anticoagulant drugs, including polymeric heparin, warfarin, hirudin, argatroban and the recently approved dabigatran, aim to reduce thrombin activity. There are several binding domains on thrombin including the active site, anion-binding exosites I and II, and the sodium binding site. We hypothesized that thrombin may be better regulated through an allosteric process mediated by small molecules binding to either exosite I or II. An appropri

APA, Harvard, Vancouver, ISO, and other styles

21

Desai, Bijoy. "Novel Allosteric Inhibitors of Thrombin." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1914.

Full text

Abstract:

Thrombin is a critical enzyme involved in blood coagulation and haemostasis. For this reason the study of its interactions with substrates, inhibitors and modulator is essential. It is also a unique enzyme in the serine protease family because unlike enzymes like trypsin and chymotrypsin its activity is modulated by various endogenous and exogenous ligands. This is due to the presence of “exosites” on the thrombin surface. Exosite II, unlike exosite-I, has not been characterized for its allosteric effect. In order to understand the structural basis of interaction and inhibition of inhibitor 4A

APA, Harvard, Vancouver, ISO, and other styles

22

Day, Jonathan Robert Stewart. "Therapeutic inhibition of thrombin signalling." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434321.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Thorstensson, Fredrik. "Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library." Doctoral thesis, Linköping : Linköpings universitet, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-4938.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Abdel, Aziz May. "Kinetic and Thermodynamic Studies of Thrombin Inhibitors." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/2956.

Full text

Abstract:

Sulfated low molecular weight lignins (LMWLs), CDSO3 and FDSO3, designed recently as macromolecular mimetics of heparin, were found to exhibit potent anticoagulant activity. Small molecules based on the same scaffold, SBD and SBT, showed promising thrombin inhibition. We were able to address the mechanism of the inhibition using Michaelis-Menten kinetics. All the molecules were found to be allosterically impairing thrombin activity using either noncompetitive or uncompetitive mechanism. Absence of competition with hirugen, an exosite 1 ligand, and competition with polymeric heparin points to e

APA, Harvard, Vancouver, ISO, and other styles

25

Betschmann, Patrick. "Strukturbasiertes Design und Synthese nichtpeptidischer Thrombin-Inhibitoren /." [S.l.] : [s.n.], 2000. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13890.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Tardy-Poncet, Brigitte. "Potential roles of TFPI in both thrombotic and hemorrhagic diseases." Thesis, Saint-Etienne, 2012. http://www.theses.fr/2012STET007T/document.

Full text

Abstract:

L'inhibiteur de la Voie du Facteur Tissulaire (TFPI) est une protéine régulatrice de la coagulation plasmatique intervenant à la phase initiale de la cascade. Il inhibe en présence de la protéine S (PS) le facteur Xa et ce complexe TFPI-Xa inactive ensuite le complexe FT-VIIa. Nous avons recherché une résistance à l'activité anticoagulante du TFPI. La sensibilité du plasma à une quantité fixe de TFPI a été évaluée sur la base d'un temps de thromboplastine diluée (TTD) réalisé avec et sans TFPI : - chez des patients ayant présenté une thrombose veineuse profonde inexpliquée ; cette résistance s

APA, Harvard, Vancouver, ISO, and other styles

27

SILVA, LEONARDO M. da. "Moojenina - Um inibidor proteico da trombina isolado do veneno da serpente Bothrops moojeni." reponame:Repositório Institucional do IPEN, 2005. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11205.

Full text

Abstract:

Made available in DSpace on 2014-10-09T12:49:28Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:02:37Z (GMT). No. of bitstreams: 1 10386.pdf: 2709613 bytes, checksum: e5193eaf23e32490bcf76fc5ad0d8789 (MD5)<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares, IPEN/CNEN-SP

APA, Harvard, Vancouver, ISO, and other styles

28

Verespy, Stephen S. III. "Probing Allosteric, Partial Inhibition of Thrombin Using Novel Anticoagulants." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4431.

Full text

Abstract:

Thrombin is the key protease that regulates hemostasis; the delicate balance between procoagulation and anticoagulation of blood. In clotting disorders, like deep vein thrombosis or pulmonary embolism, procoagulation is up-regulated, but propagation of clotting can be inhibited with drugs targeting the proteases involved, like thrombin. Such drugs however, have serious side effects (e.g., excessive bleeding) and some require monitoring during the course of treatment. The reason for these side effects is the mechanism by which the drugs’ act. The two major mechanisms are direct orthosteric and

APA, Harvard, Vancouver, ISO, and other styles

29

Rafowicz, Stéphane. "L'hirudine : un inhibiteur spécifique de la thrombine." Paris 5, 1999. http://www.theses.fr/1999PA05P130.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Dillon, Anne M. R. "An investigation of protein tyrosine phosphorylation in equine blood platelets." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390250.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Linder, Rikard. "The effect of thrombin inhibitors on coagulation activity and generation of activated protein C /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-172-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Salvagnini, Claudio. "Thrombin inhibitors grafting on polyester membranes for the preparation of blood-compatible materials." Université catholique de Louvain, 2005. http://edoc.bib.ucl.ac.be:81/ETD-db/collection/available/BelnUcetd-11232005-103604/.

Full text

Abstract:

The design of biomaterials, historically initiated and developed by physicians and engineers, in the last decades has slowly shifted toward a more biochemical based approach. For the replacement, repair and regeneration of tissues scientists are now focusing on materials that stimulate specific biological response at the molecular level. These biomaterials have already shown interesting applications in cell proliferation, differentiation, and extracellular matrix production and organization when the material modifications are designed to elicit specific interactions with cell integrins. In the

APA, Harvard, Vancouver, ISO, and other styles

33

Cullberg, Marie. "Direct Thrombin Inhibitors in Treatment and Prevention of Venous Thromboembolism: Dose – Concentration – Response Relationships." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6872.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Luz, Jefferson Rom?rio Duarte da. "Leaves of Licania rigida benth and Turnera subulata have an anticoagulant activity by thrombin inhibition." PROGRAMA DE P?S-GRADUA??O EM CI?NCIAS DA SA?DE, 2016. https://repositorio.ufrn.br/jspui/handle/123456789/22371.

Full text

Abstract:

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-03-20T19:23:41Z No. of bitstreams: 1 JeffersonRomarioDuarteDaLuz_DISSERT.pdf: 1201751 bytes, checksum: 75f1b32406c3dfccabe706f4f9d4a66e (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-03-21T22:23:37Z (GMT) No. of bitstreams: 1 JeffersonRomarioDuarteDaLuz_DISSERT.pdf: 1201751 bytes, checksum: 75f1b32406c3dfccabe706f4f9d4a66e (MD5)<br>Made available in DSpace on 2017-03-21T22:23:37Z (GMT). No. of bitstreams: 1 JeffersonRomarioDuarteDaLuz_DISSERT.pdf: 1201751 bytes, checks

APA, Harvard, Vancouver, ISO, and other styles

35

Oldgren, Jonas. "Inflammation and Coagulation Activity in Unstable Coronary Artery Disease and the Influences of Thrombin Inhibition." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl, 2001. http://publications.uu.se/theses/91-554-5182-9/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Arnljots, Björn. "On prevention of microarterial thrombosis role of protein C and protein S and thrombin inhibition /." Lund : Dept. of Plastic and Reconstructive Surgery, Malmö University Hospital, University of Lund, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39055869.html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Ni, Liming. "Synthesis and evaluation of new peptidyl phosphonate analogs of benzamidine, lysine and homolysine as irreversible inhibitors for thrombin and other trypsin-like enzymes." Diss., Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/27080.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

DE, VAULX-FREUND MONIQUE. "Thromboses experimentales : role de la thrombine, et inhibition par l'hirudine et d'autres antithrombotiques." Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR13139.

Full text

Abstract:

Les modeles animaux de thromboses, etablis in vivo, servent a comprendre les mecanismes physiopathologiques de leur installation et a trouver le moyen de les prevenir ou de les guerir. Des modeles de thromboses ont ete etablis dans differents territoires vasculaires (veine, microcirculation pulmonaire, shunt arterioarteriel recouvert de collagene). Ces thromboses sont induites par l'injection de facteur tissulaire, induisant une generation massive de thrombine dans un modele de thrombose de la microcirculation, ou associee a une stase dans le modele de thrombose veineuse. D'autres thromboses s

APA, Harvard, Vancouver, ISO, and other styles

39

Bänninger, Hans Bänninger Hans. "Binding of alpha-thrombin to fibrin depends on the quality of the fibrin network : und ; Fibrin glue in surgery: frequent development of inhibitors of bovine thrombin and human factor V /." [S.l.] : [s.n.], 1996. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Ng, Yin Dick Andy 1974. "Exploring the nature of protein-protein interactions through the design of bivalent miniproteins that bind and inhibit human thrombin." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100664.

Full text

Abstract:

The nature of protein-protein interactions was explored through the design of polypeptide ligands targeting specifically human a-thrombin. Design strategies ranged from isolation of binding fragments from natural proteins, conformational stabilization using structural scaffold, to bivalent linkage of library-selected components.<br>The interaction of thrombin with a 28-residue polypeptide from the sixth-epidermal growth factor-like repeat of human thrombomodulin (hTM-EGF6) was characterized in solution by use of NMR spectroscopy. The thrombin-binding region was identified and the thrombin-boun

APA, Harvard, Vancouver, ISO, and other styles

41

Christersson, Christina. "Regulation of Tissue Factor and Coagulation Activity : Translation Studies with Focus on Platelet-Monocyte Aggregates and Patients with Acute Coronary Syndrome." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8669.

Full text

Abstract:

<p>Myocardial infarction (MI) is often caused by a disruption of an atherosclerotic plaque with activation of coagulation, platelets and inflammation. The aims were; to investigate whether the oral direct thrombin inhibitor, ximelagatran affected markers for coagulation, platelet and inflammation in a patient cohort with recent MI and if the coagulation markers could identify patients with increased risk of new ischemic events; to evaluate some of the mechanisms involved in formation of platelet-monocyte aggregates (PMAs). </p><p>In a biomarker substudy patients with recent MI were randomized

APA, Harvard, Vancouver, ISO, and other styles

42

Verghese, Jenson. "SYNTHESIS AND BIOCHEMICAL STUDIES ON SULFATED MONOMERS OF LOW MOLECULAR WEIGHT LIGNINS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1868.

Full text

Abstract:

Anticoagulants are used as the first line therapy for management and prevention of thrombotic disorders. Thrombin and factor Xa have been the prime targets for regulation of the coagulation cascade. In this work, a small library of 17 benzofuran derivatives were synthesized and screened against thrombin and factor Xa. The derivatives that displayed inhibitory potential were docked on the exosite-II of factor Xa using a docking protocol that was developed in our research group. These compounds were based on the β-5 structural unit found in the oligomer -'CDSO3‘, which was prepared in our lab an

APA, Harvard, Vancouver, ISO, and other styles

43

Kratz, Mario Tobias Verfasser], and Michael [Akademischer Betreuer] [Böhm. "Einfluss des Thrombin-Inhibitors Dabigatran auf die endotheliale Funktion und die Atherogenese am Modell der ApoE⁻/⁻-Maus / Mario Tobias Kratz. Betreuer: Michael Böhm." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/1069532126/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Meddahi, Sadia. "Etude des activites procoagulantes liees au caillot plasmatique : comparaison de l'effet inhibiteur des molecules antithrombine dependantes ou non a activite anti iia et/ou anti xa (doctorat : pharmacotechnie et biopharmacie)." Paris 11, 1999. http://www.theses.fr/1999PA114805.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Dahlgren, Anders. "Design, synthesis, and structure-activity relationships analysis of potential inhibitors of the serine protease thrombin and the malarial aspartic proteases plasmepsin I and II /." Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2002/tek782s.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Henry, Brian Lawrence. "Novel Sulfated 4-Hydroxycinnamic Acid Oligomers as Potent Anticoagulants." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd/1462.

Full text

Abstract:

The occurrence of thrombosis in several pathophysiological conditions creates a huge need for anticoagulation therapy. Thrombin and factor Xa have been prime targets for regulation of clotting through the direct and indirect mechanism of inhibition. This work investigates chemo-enzymatically prepared oligomers of 4-hydroxycinnamic acids (DHPs) as potential anticoagulants. Oligomers were prepared through peroxidase-catalyzed oxidative coupling of 4-hydroxycinnamic acids. The products resulting from this reaction are called CDs, FDs and SDs. Structurally, these sulfated DHPs are unique and d

APA, Harvard, Vancouver, ISO, and other styles

47

Johansson, Per-Ola. "Design and synthesis of inhibitors that target the serine protease thrombin, the malarial aspartyl proteases plasmepsin I and II, and the hepatitis C virus NS3 serine protease /." Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/tek981s.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Hofer, Thomas. "Investigation of the role of platelet turnover on platelet inhibition and thrombus formation with regard to antiplatelet therapy." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8249.

Full text

Abstract:

Aspirin is often prescribed in patients with acute coronary syndromes together with an ADP-P2Y12 inhibitor such as clopidogrel or prasugrel, an established treatment protocol called dual antiplatelet therapy. Although short lived, these drugs act irreversibly upon their targets and so are used as once-a-day treatments. The daily platelet turnover in healthy humans is approximately ten to fifteen per cent but can be considerably increased in disease conditions such as diabetes or chronic kidney disease. This leads to the daily emergence of an uninhibited subpopulation among the larger populatio

APA, Harvard, Vancouver, ISO, and other styles

49

Brown, Audra Denise. "α-aminoalkylphosphonate di(chlorophenyl) esters as inhibitors of serine proteases : Part II: A kinetic study of the coupling of the hydrolysis product of the N-tosylalanine ester of 5-phenyl-3-hydroxypyrrole to various diazonium salts : Part III: Rates of thrombin acylation and deacylaton upon reaction with low molecular weight acylating agents, carbamylating agents and carbonylati". Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/27552.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Colin, Sylvie. "Nouveaux accès aux esters α-aminoboroniques". Rouen, 1999. http://www.theses.fr/1999ROUES026.

Full text

Abstract:

Ce travail présente une étude sur de nouvelles synthèses d'esters α-aminoboroniques en vue de la préparation du S18326, un inhibiteur de la thrombine développé par les laboratoires Servier. Deux stratégies générales ont été étudiées pour accéder à ces composés, reposant sur une séquence déprotonation / borylation ou sur une hydroboration. La séquence déprotonation / borylation en α d'halogène, d'oxygène, ou d'azote nous a permis d'obtenir les α-halo, α-alkoxy, et α-aminoboronates souhaités. Le meilleur résultat a été obtenu en déprotonant en α d'azote hétérocyclique. La déprotonation / borylat

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!