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Dissertations / Theses on the topic 'Thrombocytopenic Purpura'

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Published: 4 June 2021

Last updated: 26 July 2025

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1

Scully, Marie Ann. "The pathogenesis of thrombotic Thrombocytopenic Purpura." Thesis, University College London (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498417.

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2

Wenger, Martin. "Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura /." [S.l : s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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3

Mancini, I. "ADAMTS13-RELATED ASSAYS IN ACQUIRED THROMBOTIC THROMBOCYTOPENIC PURPURA." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/217173.

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Thrombotic thrombocytopenic purpura (TTP) is a rare but life-threatening microangiopathic disorder, due to the persistence of highly thrombogenic ultra large (UL) von Willebrand factor (VWF) multimers in the microcirculation. TTP is associated with the severe deficiency of ADAMTS13 (activity <10%), the metalloprotease responsible for the proteolytic regulation of VWF multimers size. In the acquired form of the disease, the severe deficiency of ADAMTS13 is caused by anti-ADAMTS13 antibodies that inhibit ADAMTS13 activity (neutralizing anti-ADAMTS13 antibodies or inhibitors) and/or increase its

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4

Treutiger, Iris. "Idiopathic thrombocytopenic purpura in childhood : clinical features, diagnostics and treatment /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-084-2/.

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5

Najaoui, Abderrahim [Verfasser]. "Komplement-Bindende Autoantikörper in immune thrombocytopenic purpura / Abderrahim Najaoui." Gießen : Universitätsbibliothek, 2011. http://d-nb.info/1063111390/34.

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6

Hon, Fung-yan, and 韓鳳恩. "The clinical utility of ADAMTS13 assays in the diagnosis of thromboticthrombocytopenic purpura." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46699740.

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7

Lam, Wang-hoi, and 林宏凱. "ADAMTS13 assays in thrombotic microangiopathy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48334029.

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Thrombotic microangiopathy is featured by microangiopathic haemolytic anaemia, thrombocytopenia and the presence of peripheral fragmented red cells. Thrombotic thrombocytopenic purpura (TTP) is the major disease entity of concern, which is caused by a congenital or acquired deficiency of a von Willebrand factor (vWF) cleaving protease known as ADAMTS13 (A Disintegrin And Metalloprotease with Thrombospondin type 1 motif, member 13). Deficiency of this protease, leads to accumulation of uncleaved ultra-large hyperactive vWF multimers in peripheral circulation causing the extensive microvascular

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8

Houwerzijl, Ewout Johan. "Studies on megakaryopoiesis in patients with myelodysplasia and idiopathic thrombocytopenic purpura." [S.l. : Groningen : s.n. ; University Library of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/306088665.

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9

Cooper, Nichola. "Investigating the therapeutic options and pathobiology of immune thrombocytopenic purpura in adults." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424696.

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10

Karpman, Diana O. "Studies of the pathogenesis of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura." Lund : Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/68945090.html.

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11

Crossley, Alison Rachel. "Immunological parameters in immune thrombocytopenic purpura and the effects of alpha interferon therapy." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308323.

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12

Tate, Helena. "The effect of single nucleotide polymorphisms and mutations on congenital thrombotic thrombocytopenic purpura phenotype." Thesis, University of Westminster, 2017. https://westminsterresearch.westminster.ac.uk/item/q430y/the-effect-of-single-nucleotide-polymorphisms-and-mutations-on-congenital-thrombotic-thrombocytopenic-purpura-phenotype.

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Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease with a reported incidence of 6 cases per million per year in the UK. It is characterised by episodes of microangiopathic haemolytic anaemia and thrombocytopenia, with the widespread presence of platelet-rich thrombi in the microcirculation, leading to end-organ damage. TTP is a clinically heterogeneous disorder caused by autoantibody inhibition or clearance or by a deficiency in activity or secretion of the von Willebrand factor cleaving protease (ADAMTS13). Over 100 mutations have been identified in ADAMTS13 yet, in

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13

Imholz, Beat. "Intravenous immunoglobulin (i.v. IgG) for pretreated acute and chronic idiopathic thrombocytopenic purpura (ITP) in childhood /." [S.l : s.n.], 1986. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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14

Barbosa, Alzira Maria de Castro. "Chronic immune thrombocytopenic purpura and infection Helicobacter pylori: platelet response to the bacteria elimination of treatment." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16378.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>The Chronic Immune Thrombocytopenic Purpura (ITPc) is a condition caused by autoimmune response resulting awareness of platelets by self antiplatelet antibodies, causing lysis of platelets. Infection with H. pylori has been shown to likely factor for the development of PTIc, with possible platelet response relationship in PTIc after treatment of bacterial eradication. The objective was to evaluate possible effects of eradication of Helicobacter pylori in the number of platelets of patients with PTIC patients at the University Hos

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15

Mazzucco, Karina Lorenzi Marramarco. "Avaliação dos linfócitos T reguladores na púrpura trombocitopênica imune da infância." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/87155.

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Objetivo: Avaliar a freqüência das células T reguladoras (Tregs) em crianças com diagnóstico novo de Púrpura Trombocitopênica Imune (PTI) e a sua associação com a contagem de plaquetas na ocasião, comparando os achados com os de controles saudáveis. Pacientes e Métodos: Foi realizado um estudo caso-controle, no qual foram incluídos 19 pacientes com diagnóstico novo de PTI e 19 controles. Para cada um dos casos, foram coletadas quatro amostras de sangue em períodos distintos, sendo eles ao diagnóstico – antes da instituição de qualquer terapêutica – e após um, três e seis meses do mesmo. Para o

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16

Underwood, M. I. "The relationship between ADAMTS13 genotype and phenotype in congenital thrombotic thrombocytopenic purpura and characterisation of ADAMTS13 mutants." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1462706/.

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Congenital thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy, usually involving ADAMTS13 gene defects. ADAMTS13 processes the multimeric plasma glycoprotein Von Willebrand factor making it less reactive to platelets. Patients differ in terms of disease severity and evidence suggests a relationship between ADAMTS13 genotype and disease phenotype. Over 140 mutations have been identified in patients but only ~30% of these has been expressed in vitro. The aim of this thesis was to study certain ADAMTS13 mutations identified in a homozygous form in congenital TTP patients to

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17

Aghabeigi, N. "Identification and characterisation of anti-platelet antibodies in ITP patients." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5265.

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18

Seth, Yunus S. "Review and re-appraisal of patients treated with splenectomy for immune thrombocytopenic purpura at five years and beyond." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/2833.

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Includes bibliographical references.<br>The risk of pneumococcal infection post splenectomy is life long so all patients undergoing splenectomy are given polyvalent (23-valent) unconjugated pneumococcal polysaccharide vaccine, preoperatively. The aim of this study was 1. to measure the success of splenectomy at a tertiary institution at 5 years and beyond. 2. To review the incidence of complications peri-operatively and long term. 3. Review the need for possible re-vaccination (as recommended in American and British guidelines and 4. perform a re-appraisal of patients found to be refractory to

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Олексич, Т. В., В. В. Ульянич та О. М. Смородська. "Постспленектомічний спленоз, як предиктор розвитку рецидиву хвороби Верльгофа". Thesis, Сумський державний університет, 2015. http://essuir.sumdu.edu.ua/handle/123456789/42241.

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Спленектомія (СЕ) у хворих на хворобу Верльгофа (ХВ), виконується у випадку неефективності консервативного лікування цього тяжкого захворювання. Не зважаючи на високий ризик оперативного втручання, пов'язаний з притаманним для цього захворювання порушеннями в системі згортання крові, СЕ продовжує активно використовуватися , так як є найбільш ефективним методом лікування ХВ.

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20

Glanz, Jason M. "The risk of idiopathic thrombocytopenic purpura (ITP) following measles, mumps, and rubella (MMR) vaccination : attributable risk and a simulation study to evaluate four study designs /." Connect to full text via ProQuest. IP filtered, 2005.

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21

Прилуцька, І. С., та Ю. В. Козюра. "Обгрунтування використання спленектомії при хворобі Верльгофа". Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/36478.

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Ідіопатична тромбоцитопенічна пурпура (ІТП) – гематологічне захворювання, що характеризується скороченням часу життя тромбоцитів і зниженням їх рівня у крові. Середня тривалість життя тромбоцитів при ІТП зменшується до 15 годин, тоді як в нормі вона складає 220 годин. Симптоми ІТП описав ще Гіппократ, а у 1735 році Werlhof виділив ІТП як самостійну нозологічну одиницю. При неефективності консервативної терапії – методом вибору залишається спленектомія (СЕ). Оперативне втручання у гематологічних хворих супроводжується низкою специфічних післяопераційних ускладнень і технічно більш складне порів

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22

Vilela, Josie Fadul 1982. "Investigação dos polimorfismos dos genes da interleucina-1 (IL-1), IL1RN, IL-4, IL-6 e IL-10 em pacientes adultos portadores de púrpura trombocitopênica imune = Investigation of interleukin-1 (IL-1), IL1RN, IL-4, IL-6 and IL-10 gene polymorphism adult patients with immune thrombocytopenic purpura." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310653.

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Orientador: Marcelo Addas Carvalho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T03:08:54Z (GMT). No. of bitstreams: 1 Vilela_JosieFadul_M.pdf: 1739915 bytes, checksum: ea1d6c47907a49ccd0e00255b01d3dee (MD5) Previous issue date: 2012<br>Resumo: A Púrpura Trombocitopênica Imune (PTI) é uma doença autoimune caracterizada pela presença de autoanticorpos contra as glicoproteínas de membrana plaquetária, tais como GPIIb/IIIa e GPIb/IX. O processo patogênico da PTI envolve uma destruição acelerada das plaqueta

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23

Gilardin, Laurent. "Identification des épitopes T d’ADAMTS13 chez les patients atteints de Purpura Thrombotique Thrombocytopénique The ADAMTS13¹²³⁹-¹²⁵³ peptide is a dominant HLA-DR1-restricted CD4⁺ T-cell epitope Purpura Thrombotique Thrombocytopénique : physiopathologie, clinique, pronostic et traitement In silico calculated affinity of FVIII-derived peptides for HLA class II alleles predicts inhibitor development in haemophilia A patients with missense mutations in the F8 gene In silico prediction of immuno-dominant T-cell epitopes on human therapeutic factor VIII Predictive immunogenicity of Refacto AF Complement C3 is a novel modulator of the anti-factor VIII immune response Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS520.

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Le purpura thrombotique thrombocytopénique (PTT) est une maladie autoimmune rare et grave caractérisée par la présence d’anticorps dirigés contre ADAMTS13 (A13), une protéase impliquée dans l’hémostase primaire. L’implication des lymphocytes T CD4⁺ spécifiques d’ADAMTS13, dans la physiopathologie de la maladie est suggérée par une restriction pour l’haplotype HLA-DRB1*11 (DR11), l’isotype IgG des anticorps. Dans ce travail, nous avons cherché à identifier les épitopes T d’A13. Tout d’abord, nous avons sélectionné in silico les peptides d’A13 susceptibles d’être présentés par les molécules HLA-

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24

Bassitt, Rogerio Pastore. "Resposta da púrpura trombocitopênica idiopática à esplenectomia tardia." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/5/5136/tde-03042002-205658/.

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A púrpura trombocitopênica idiopática (PTI) é uma patologia adquirida que leva à redução da contagem de plaquetas, mediada por mecanismo imunológico. O tratamento inicial é a corticoterapia e, se caracterizada a falência ou dependência desta, a esplenectomia é a segunda opção. Autores recomendam que a esplenectomia seja realizada antes de se completarem 12 meses do diagnóstico, apesar de estudos sugerirem que a resposta após este período é semelhante. Neste estudo, pesquisaram-se a eficácia da esplenectomia tardia, as complicações da manutenção da terapia imunossupressora e as complicações he

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Almeida, Gabriella Erlacher Lube de. "Síndrome de Evans em pacientes com lúpus eritematoso sistêmico juvenil." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-15122017-132820/.

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Introdução: Estudos avaliando a prevalência de síndrome de Evans (SE) no lúpus eritematoso sistêmico juvenil (LESJ) bem como possíveis fatores associados são restritos a poucos relatos de caso. Objetivos: Avaliar a prevalência de SE em uma grande população de LESJ, assim como sua possível associação com dados demográficos, manifestações clínicas, características laboratoriais, atividade/dano cumulativo da doença e tratamento. Métodos: Um estudo de coorte multicêntrico retrospectivo foi realizado em 10 serviços de Reumatologia Pediátrica provenientes do Grupo Brasileiro de Lúpus e incluiu 850 p

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Rivière, Étienne. "Implication de la protéine Bcl-xL dans la mégacaryopoïèse humaine normale et dans le purpura thrombopénique immunologique chronique." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0148/document.

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La protéine Bcl-xL fait partie de la famille des protéines anti-apoptotiques Bcl-2. Il a été montré que cette protéine avait un rôle majeur dans la formation des plaquettes chez la souris (mégacaryopoïèse). Une dérégulation de cette protéine pourrait aboutir à une altération de la mégacaryopoïèse et donner des pathologies humaines comme des thrombopénies chroniques. Une des causes de thrombopénies chroniques est le purpura thrombopénique immunologique (ou PTI), qui associe deux mécanismes physiopathologiques : une destruction auto-immune des plaquettes et une insuffisance de leur production pa

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Audia, Sylvain. "Etude physiopathologique de la réponse immunitaire au cours de la thrombopénie immunologique (purpura thrombopénique immunologique)." Phd thesis, Université de Bourgogne, 2010. http://tel.archives-ouvertes.fr/tel-00687984.

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La thrombopénie immunologique ou purpura thrombopénique immunologique (PTI) est une maladie auto-immune rare responsable d'une destruction périphérique immunologique des plaquettes associée à une production médullaire inadaptée. Dans la première partie de ce travail, nous exposons les connaissances actuelles de sa physiopathologie ainsi que certaines données concernant la réponse immunitaire T, le rôle des lymphocytes T régulateurs (Treg), l'implication de la rate dans la réponse immunitaire ainsi que les modes d'action d'une thérapeutique anti-lymphocytaire B, le rituximab. Dans une seconde p

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Ebbo, Mikaël. "Rôle des cellules lymphoïdes innées chez l'homme : analyse au cours de déficits immunitaires, pathologies auto-immunes et inflammatoires." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0398.

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Les cellules lymphoïdes innées (ILCs) sont des populations cellulaires d’identification récente, mais leur rôle in vivo chez l’homme reste mal connu. Dans une 1ère étude, nous avons pu montrer qu’un déficit sévère en NK au cours de déficits immunitaires communs variables est associé à un risque accru de manifestations non infectieuses et infectieuses bactériennes sévères, suggérant un rôle protecteur non redondant des cellules NK lorsque le système immunitaire adaptatif n’est pas fonctionnel. Dans une 2ème étude, nous avons montré que des patients atteints de déficits immunitaires combinés sév

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Lévy, Eva. "Identification de causes génétiques du syndrome d’Evans pédiatrique." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB017/document.

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Le syndrome d'Evans est défini par l'existence concomitante ou séquentielle de cytopénies auto-immunes, le plus souvent, anémie hémolytique et thrombopénie immunologique. Chez l'enfant, il peut être secondaire à une infection, une maladie auto-immune systémique ou un déficit immunitaire primitif. Alternativement, chez une grande partie des patients, l'étiologie n'est pas clairement identifiée. Les patients atteints de syndrome d'Evans présentent parfois d'autres atteintes, telles une auto-immunité d'organe, une lymphoprolifération bénigne ou un déficit immunitaire. L'objectif de ce travail éta

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REN, JIN-JIN, and 任晶晶. "Investigations of anti-platelet antibodies in idiopathic thrombocytopenic purpura patients." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/35002976605057943157.

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Mbao, Melvin. "Immune thrombocytopaenia at a central hospital in Johannesburg." Thesis, 2016. http://hdl.handle.net/10539/22308.

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A Research Report submitted to the Faculty of Health Sciences, University of Witwatersrand, Johannesburg, in partial fulfilment of the degree of Master of Medicine in the branch of Internal Medicine.<br>Background. Primary immune thrombocytopenia (ITP) is a rare disease causing significant morbidity. South Africa has a high prevalence of HIV infection which may be associated with immune thrombocytopenia. There is a paucity of clinical, management and outcome data on immune thrombocytopenia in the local South African setting. Objectives. To compare the demographics, clinical presentation, mana

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Matias, Miguel João Ribeiro. "A health related quality of life approach to immune thrombocytopenic purpura : systematic review." Master's thesis, 2017. http://hdl.handle.net/10451/32624.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2017<br>Objectives: Immune thrombocytopenic Purpura is a chronic autoimmune disease caracterized by the reduction in platelet levels and the consequential hemorrhagic dyscrasia. As of today there are no curative approaches, with therapeutical development focusing on symptoms and the prevention of dire consequences. Therefore it’s a disease with a high impact in quality of life. The current systematic review identified studies that measured the impact on quality of life of the different the

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Peng, Ching-Tien, and 彭慶添. "Interleukin 4, Interleukin 6 and Interleukin 10 Polymorphisms in hildren with Acute and Chronic Immune Thrombocytopenic Purpura." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/45642966379287782857.

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碩士<br>臺中健康暨管理學院<br>健康管理研究所<br>93<br>Inflammatory cytokines are essential to the regulation of immune thrombocytopenic purpura (ITP). We investigated intron 3 variable number of tandem repeats of interleukin (IL)-4, IL-6 (-572 G/C), and IL-10 (-627 C/A) polymorphisms in 50 children with acute ITP, 30 children with chronic TIP, and 100 healthy individuals by polymerase chain reaction-based restriction analysis. There were significant differences in RP1/RP2 genotype proportion (13.3% versus 33.0%, p=0.04, odds ratio= 0.3, 95% CI=0.1-1.0) and RP2 allelic frequency (6.7% versus 19.5%, p=0.03, odds

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Τσίτουρας, Κωνσταντίνος. "Η δράση της λεπτίνης στην παιδική ιδιοπαθή θρομβοπενική πορφύρα". Thesis, 2011. http://nemertes.lis.upatras.gr/jspui/handle/10889/4540.

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Η σύνθεση της λεπτίνης γίνεται κατά κύριο λόγο από τα αδιποκύτταρα και η δράση της είναι να περιορίζει την πρόσληψη της τροφής και να προάγει τον καταβολισμό του λίπους. Έχει δειχτεί, επίσης, ότι η λεπτίνη προάγει την ενεργοποίηση των μονοκυττάρων και των Τ λεμφοκυττάρων in vitro, και σε πειραματικά μοντέλα (ποντίκια) αυτοάνοσων νοσημάτων συμμετέχει στην επαγωγή της ανοσολογικής απάντησης, πιθανότατα μέσω της κλωνικής έκπτυξης και της διατήρησης παθολογικών Τh1 λεμφοκυττάρων. Για τη διερεύνηση των δράσεων της λεπτίνης στην Αυτοάνοση Ιδιοπαθή Θρομβοπενική Πορφύρα της παιδικής ηλικίας, μετρήσα

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Garizio, Dominique Gilda. "Von Willlebrand Factor cleaving protease levels in patients with HIV related thrombocytopenia." Thesis, 2009. http://hdl.handle.net/10539/6051.

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Abstract Background: Deficiency of Von Willebrand Factor Cleaving Protease (VWFCP) has been implicated as the cause of Thrombotic Thrombocytopenic Purpura (TTP). TTP is a lifethreatening disease characterised by microangiopathic thrombosis due to accumulation of Ultralarge Von Willebrand Factor (ULVWF) multimers. The clinical features of TTP include microangiopathic haemolysis and thrombocytopenia. TTP is being seen with increased frequency in the context of HIV. However, in the context of HIV infection, cytopenias are often multifactorial in nature and levels of VWFCP in HIV-related th

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Lindsey, Nigel J., M. Behrendt, M. Hamidpour, L. J. Partridge, and B. Griffiths. "The isolation and characterisation of antiplatelet antibodies." 2006. http://hdl.handle.net/10454/2839.

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No<br>The isolation and characterisation of antiplatelet antibodies in autoimmune thrombocytopenia purpura patients (ITP) is described. Autoimmune thrombocytopenia purpura is an autoimmune disease, clinically defined by low platelet counts, normal or increased megakaryocytopoiesis and antiplatelet antibodies in serum. This study used phage display to isolate Fab antiplatelet antibodies to study the structure-function relationships of pathogenic antibodies in ITP. Out of six randomly selected colonies, four colonies reacted strongly with whole platelets in enzyme-linked immunosorbent assay (ELI

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Fidalgo, Teresa de Jesus Semedo. "Von Willebrand factor and ADAMTS13 : Duality in hemorrhagic and thrombotic disease." Doctoral thesis, 2017. http://hdl.handle.net/10316/79593.

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Tese de doutoramento em Biociências, no ramo de Biologia Celular e Molecular, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>Haemostasis is a normal defence mechanism that requires the combined activity of vascular, platelet and plasma factors. Under physiologic conditions, a haemostatic balance is achieved through the effects of natural procoagulant and anticoagulant factors which, in equilibrium with each other, provide haemostasis at the sites of vascular injury. Abnormalities of these haemostasis factors can lead to exce

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Cendron, Angela. "The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa." Thesis, 2005. https://vuir.vu.edu.au/15580/.

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FcyRIIa is an activatory receptor and contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain, involved in the initiation of signalling events. There is now strong evidence from transgenic mouse models and human genetic susceptibility studies that implicate FcyRIIa in a number of immune diseases including, rheumatoid arthritis, systemic lupus erythematosus (SLE) and immune thrombocytopenia purpura (ITP). FcyRHa is therefore a promising target for the development of therapeutics to treat these diseases.

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