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Relevant bibliographies by topics / Thrombose – Diagnostic

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Academic literature on the topic 'Thrombose – Diagnostic'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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Journal articles on the topic "Thrombose – Diagnostic"

1

Delsart, D., G. Girard, N. Moulin, K. Rivron-Guillot, and H. Décousus. "Thrombose veineuse : diagnostic et traitement." EMC - Médecine d 'urgence 2, no. 1 (January 2007): 1–14. http://dx.doi.org/10.1016/s1959-5182(07)73324-x.

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Chacar, H. R., R. K. Hejeily, and A. Aouad. "Thrombose du sinus caverneux retard au diagnostic et complications." Archives de Pédiatrie 6 (January 1999): S540. http://dx.doi.org/10.1016/s0929-693x(99)81640-6.

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Maufus, M., A. Delluc, G. Le Gal, P. Quehe, D. Mottier, and L. Bressollette. "Thrombose veineuse profonde en cocarde, un nouveau diagnostic échographique." Journal des Maladies Vasculaires 34 (September 2009): S28—S29. http://dx.doi.org/10.1016/j.jmv.2009.07.037.

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Huret, B., S. Boulanger, and M. Bure. "Diagnostic fortuit d’une thrombose veineuse profonde en échoendoscopie bronchique." Revue des Maladies Respiratoires 36, no. 4 (April 2019): 561–62. http://dx.doi.org/10.1016/j.rmr.2018.11.003.

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Barbar, S. D., M. Rondeau, F. Lange, and J. C. Weber. "La thrombose de la veine azygos, un surprenant diagnostic histologique." La Revue de Médecine Interne 24 (December 2003): 476s—477s. http://dx.doi.org/10.1016/s0248-8663(03)80590-8.

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Courdurie, A., J. G. Fuzibet, C. Kannengiesser, E. Lainey, A. Renneville, P. Rohrlich, and T. Cluzeau. "Thrombose intra médullaire conduisant au diagnostic d’un syndrome des télomères courts." La Revue de Médecine Interne 38 (June 2017): A124—A125. http://dx.doi.org/10.1016/j.revmed.2017.03.151.

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7

Elias, A., M. Maufus, M. Elias, M. A. Sevestre, and G. Pernod. "Diagnostic de la récidive de thrombose veineuse profonde des membres inférieurs." JMV-Journal de Médecine Vasculaire 42, no. 2 (March 2017): 85. http://dx.doi.org/10.1016/j.jdmv.2017.01.072.

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Ouarhlent, Yamina, Hamida Laiadhi, Rabeh Chafai, and Habiba Zidani. "Thrombosis revealing malignant haemopathies. Report of 2 cases." Batna Journal of Medical Sciences (BJMS) 3, no. 2 (December 31, 2016): 132–33. http://dx.doi.org/10.48087/bjmscr.2016.3218.

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Le risque de survenue de thromboses est augmenté dans les affections hématologiques, en particulier les hémopathies malignes et ce au moment du diagnostic et pendant le traitement par chimiothérapie. Mais aussi, les thromboses peuvent précéder de plusieurs mois la survenue d’hémopathies malignes et par conséquent, ces complications thrombotiques peuvent compromettre le pronostic vital. Donc dans l’enquête étiologique des thromboses, il est judicieux de penser à une hémopathie maligne sous-jacente et de ce fait nous rapportons deux observations qui illustrent la survenue de thromboses dans les hémopathies malignes.

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Noël-Savina, Élise, Gilles Quéré, Sylvie Gouva, Gilles Robinet, and Renaud Descourt. "Infection et thrombose sur chambre implantable : diagnostic et prise en charge thérapeutique." Bulletin du Cancer 98, no. 9 (September 2011): 1107–18. http://dx.doi.org/10.1684/bdc.2011.1403.

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Constans, J., C. Boutinet, R. Salmi, J. C. Saby, P. Baudouin, M. L. Nelzy, F. Sampoux, et al. "Scores de prédiction du diagnostic de thrombose veineuse profondeen medecine de ville." La Revue de Médecine Interne 22 (December 2001): 458s—459s. http://dx.doi.org/10.1016/s0248-8663(01)80083-7.

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Dissertations / Theses on the topic "Thrombose – Diagnostic"

1

ROUILLARD, PHILIPPE. "Apport de l'irm au diagnostic des thromboses veineuses cerebrales." Lille 2, 1991. http://www.theses.fr/1991LIL2M284.

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Chebil, Syrine. "Elaboration de nouveaux biocapteurs électrochimiques pour le diagnostic de la thrombose veineuse profonde." Paris 11, 2010. http://www.theses.fr/2010PA112175.

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La thrombose veineuse profonde (TVP) comme sous le nom de phlébite correspond à la formation d'un caillot sanguin dans une veine. C'est une pathologie fréquente en Europe et elle reste très difficile à diagnostiquer jusqu'à présent. Ce travail qui rentre dans le cadre d'un projet Européen STREP C] consiste à élaborer un biomatériau en tant qu'outil de diagnostic de la thrombose permettant une mesure en temps réel de la présence de la maladie dans le sang du patient. La détection est réalisée par dosage de la glycoprotéine D-Dimère présente lors de la formation d'un thrombus. L'approche qui a été envisagée dans cette étude est celle de l'immobilisation de l'anticorps anti-D-Dimère tagué Histidine sur un matériau polymérique conducteur fonctionnalisé par un complexe métallique. Cette stratégie originale de la construction de l'immunocapteur réalisée étape par étape a permis à la fois d'avoir une fixation orientée de l'anticorps et de suivre la variation du signal électrochimique via le métal utilisé en tant que sonde redox. De ce fait un biocapteur a été développé à base de polypyrrole fonctionnalisé par le complexe métallique Acide NitrilotriacétiquelMétal ionique (NT AJCu2+) et a été intégré par la suite dans un dispositif miniaturisé conçu pour être fiable, précis, portatif, automatisé et économique. L'étude de stabilité dans le temps de ce biomatériau a permis la réalisation d'une nouvelle matrice d'immobilisation de l'anticorps anti-D-Dimère en utilisant un nouveau ligand enPI2 constitué par des groupements amines comms pour une très bonne chélation du cuivre II. La conception du biocapteur sur des nanomatériaux tels que les nanotubes de carbone et les nanoparticules d'or a montré une augmentation de la gamme de détection du D-Dimère. La caractérisation de ces biomatériaux et le suivi du D-Dimère ont nécessité l'utilisation de différentes techniques d'analyses électrochimique et de surface tels que la voltammétrie cyclique (CV), la DPV, la spectroscopie d'impédance électrochimique (SIE), la microscopie à force atomique (AFM), la résonance des plasmons de surface (SPR), L'infrarouge à transformée de Fourrier (FTIR), la spectroscopie des photoélectrons X (XPS) et la résonance magnétique nucléaire (RPE). L'intégration du biocapteur dans la cartouche DVT-IMP comprenant une puce et un corps micro fluidique a permis l'amplification du signal électrochimique notamment de la sonde redox grâce à l'utilisation des élecctrodes interdigitées (EIDs)
Deep vein thrombosis (DVT) known as phlebitis corresponds to the formation of a blood clot in a vein. It is a common disorder in Europe and it remains very difficult to diagnose until now. This work within the framework of a European project STREP [] is to develop a biomaterial as a tool for diagnosis of thrombosis allowing real-time measurement of the presence of the disease in the patient's blood. Detection is perfonned by assaying the glycoprotein D-dimer present during the formation of a thrombus. The approach which has been chosen in this study is the immobilization of an Histidine tagged anti-D-Dimer on a conductive polymer material functionalized with a metal complex. This original strategy for the construction of the immunosensor has been achieved step by step allowed both to have an oriented attachment of the antibody and monitor the change in electrochemical signal through the metal used as a redox probe. Thus a biosensor based on polypyrrole functionalized with nitrilotriacetic acid metal complex (NT AJCu2 +) was developed and was subsequently incorporated into a miniaturized device designed to be reliable, accurate, portable, automated and economical. The study of the biomaterial time stability has enabled the creation of a new matrix for the anti-D-dimer immobilization using a new ligand enPI2 containing amine groups known for a very good Copper II chelation. The design of the biosensor on nanomaterials such as carbon nanotubes and gold nanoparticles showed an increase in the D-dimer detection range. The characterization of these biomaterials and the D-dimer monitoring required the use of different electrochemical and surface analytical techniques such as cyclic voltammetry (CV), DifferentiaI Pulse Voltammetry (DPV), the electrochemical impedance spectroscopy (EIS), the Atomic force microscopy (AFM), the surface plasmon resonance (SPR), The Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS) and nuclear paramagnetic resonance (EPR). The integration of the biosensor in the DVT-IMP cartridge comprising a chip and a microfluidic body allowed the amplification of the electrochemical signal including the redox probe through the use of interdigitated élecctrodes (EIDs)

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PUMO, JEAN-FRANCOIS. "Diagnostic radiologique des thromboses veineuses portales : a propos de 45 cas." Nice, 1994. http://www.theses.fr/1994NICE6520.

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Marty, Dominique. "Diagnostic et traitement des thromboses veineuses profondes chez la femme enceinte : a propos de deux cas." Toulouse 3, 1992. http://www.theses.fr/1992TOU31072.

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Jacobin-Valat, Marie-Josée. "Nouvelles perspectives pour le diagnostic et la thérapie des pathologies myocardiques et thrombotiques : obtention d'anticorps monoclonaux humains recombinants." Bordeaux 2, 2001. http://www.theses.fr/2001BOR28853.

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Le suivi immunoscintigraphique des pathologies myocardiques et le traitement des pathologies coronariennes nécessitent le développement de nouvelles sondes injectables à l'homme sans danger. D'où notre intérêt pour les AcM. Ainsi l'IgM humaine B7 anti-myosine obtenue par l'équipe de recherche, présente un potentiel dans la détection des nécroses myocardiques et le diagnostic précoce d'éventuels rejets de greffe. Les applications cliniques nécessitant une clairance et une pénétration tissulaire optimum, des fragments scFv ont été élaborés par ingénierie moléculaire. Dans le cadre des pathologies coronariennes, les antagonistes de l'intégrine αIIbβ3 ont suscité l'intérêt en tant qu'outil de diagnostic et de thérapie des thromboses. L'AcM murin XIIF9 spécifique de la conformation de l'αIIbβ3 exprimée sur les plaquettes activées, présente une bonne fixation ex vivo des thrombi sur un modèle animal de l'athérosclérose. Les antagonistes, en inhibant la formation du complexe αIIbβ3 /fibrinogène, réduisent les épisodes thrombotiques chez les patients à risque. Trois banques combinatoires humaines d'anticorps ont été développées à partir des cellules B de patients immunisés contre l'intégrine αIIbβ3 lors de pathologies telles la Thrombasthénie de Glanzmann (EB) ou le Purpura Thrombopénique AutoImmun (TE et BO). Des phages-anticorps recombinants spécifiques de l'intégrine sous sa conformation activée, ont été isolés selon la méthode d'expression de fragments d'anticorps à la surface de phages filamenteux. Notre étude a montré la nature polyclonale de la réponse immunitaire développée, la pathogénicité des auto-anticorps déterminée par l'accumulation de mutations au niveau des régions CDRS et l'émergence de motifs récurrents au niveau des CDR3H. De plus, le potentiel d'inhibition de l'agrégation plaquettaire des formes solubles scFv de certains clones a été clairement démontré lors d'études d'affinité et d'inhibition par le fibrinogène
Scintigraphic studies of myocardial pathologies and the treament of Acute Coronary Syndrome (ACS) show the necessity to obtain a new class of agents that could be injected in humans without provoking the immune system. It's the reason why we chose to study the diagnostic and therapeutic potential of human mAbs. The ability of a monospecific human IgM Mab (B7) obtained by the research team, to bind to human heart myosin suggests that this mAb may be useful in the imaging of mycordial necrosis after myocarditis of graft rejection. Owing to the fact that the parent molecule is an IgM, the scFv fragment were constructed by molecular ingineering to alleviate problems such as a poor diffusion and a slow penetration inside necrotic myocytes. For a purpose of detection of newly formed thrombi, we determined the feasibility of imaging thrombi using a 123-I labeled murine Mab XIIF9 in an atherosclerotic rabbit model of acute arterial thrombosis. This Mab presented with high affinity and specificity for αIIbβ3 expressed on activated platelets holds promise for ACS imaging. Moreover, we have made a great deal of efforts towards developping αIIbβ3 inhibitors that block fibrinogen inducing platelet aggregation and have a more significant impact for therapeutic management of patients with ACS than currently used αIIbβ3 antagonists. We have succeeded in generating three libraries of single-chain antibodies (TE, EB and BO) from the B cells of patients with Glanzmann's Thrombasthenia or AutoimmuneThrombocytopenic Purpura developing in their sera antibodies against the αIIbβ3 integrin. We obtained several specific recombinant phage-antibodies stemmed from studied patients by phage display of single-chain antibodies on the surface of filamentous phage, some of them recognising the activated form of the integrin. A first important conclusion issuing from our results is that the immune reaction occurring during these diseases consists of a polyclonal hypermutations displayed in the complementarity-determining regions by anti-αIIbβ3 fragments supports the hypothesis of the pathogenesis of developing antibodies. Thirdly, CDR3H analysis of phage-antibodies points out recurrent patterns. Affinity studies and assays for inhibition of platelet aggregation clearly show the therapeutic potential of some of these recombinant antibodies

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Le, Bouffant Françoise. "Le lupus anticoagulant : recherche d'une corrélation entre les différents tests biologiques permettant le diagnostic." Bordeaux 2, 1992. http://www.theses.fr/1992BOR2P057.

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7

Terral, Christophe. "Thromboses veineuses profondes révélatrices de cancers : à propos de 6 cas." Montpellier 1, 1992. http://www.theses.fr/1992MON11031.

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8

BOUHET, CUCHE ANNE. "Interet de l'echographie couplee au doppler pulse avec codage couleur dans le diagnostic des thromboses portales recentes chez l'adulte." Besançon, 1991. http://www.theses.fr/1991BESA3063.

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9

EL, ALAMI PAYELLE NATHALIE. "Dosage des d. Dimeres en urgence : interet dans le diagnostic de la maladie veineuse thrombo-embolique." Rennes 1, 1992. http://www.theses.fr/1992REN1M033.

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Pometan, Bruno. "Ischémie aigue distale du membre supérieur au cours de la pratique sportive : à propos de deux cas." Bordeaux 2, 1999. http://www.theses.fr/1999BOR2M092.

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Books on the topic "Thrombose – Diagnostic"

1

Ansell, Jack E. Handbook of hemostasis and thrombosis: A diagnostic and therapeutic approach. Boston: Little, Brown, 1986.

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Lockwood, Charles J. Thrombosis, thrombophilia and thromboembolism. Washington, DC: American College of Obstetricians and Gynecologists, 2007.

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3

Ogston, Derek. Venous thrombosis: Causation and prediction. Chichester: Wiley, 1987.

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Handbook of hemostasis and thrombosis: A diagnostic and therapeutic approach. Boston: Little, Brown, 1986.

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International, Symposium on Experimental and Clinical Aspects of Cerebral Sinus Thrombosis (1987 Nymphenburg Munich Germany). Cerebral sinus thrombosis: Experimental and clinical aspects. New York: Plenum Press, 1990.

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W, Hoyer Leon, and Drohan William, eds. Recombinant technology in hemostasis and thrombosis. New York: Plenum Press, 1991.

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Tinkler, Kerry. Setting up, piloting, implementing and reviewing a GP direct access service for the diagnosis of lower limb deep vein thrombosis. Portsmouth: University of Portsmouth, 2004.

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MD, Spencer Fredrick A., ed. Dx/Rx. Sudbury, MA: Jones and Bartlett Publishers, 2005.

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Bergan, John J. Management of venous disorders. Georgetown, Tex., U.S.A: Landes Bioscience, 2000.

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Marques, Marisa B. Quick guide to hemostasis. Washington, DC: American Association for Clinical Chemistry, 2015.

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Book chapters on the topic "Thrombose – Diagnostic"

1

Kahlke, V., and J. Jongen. "Hämorrhoidalleiden, perianale Thrombosen, Marisken." In Proktologische Diagnostik, 59–73. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-47262-0_7.

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Földi, M. "Lymphologie des Beines, Diagnostik und Therapie." In Varizen, Ulcus cruris und Thrombose, 370–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-69059-4_9.

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James, Paula, and David Lillicrap. "Molecular Diagnostic Approaches to Hemostasis." In Practical Hemostasis and Thrombosis, 25–36. Oxford, UK: Wiley-Blackwell, 2010. http://dx.doi.org/10.1002/9781444306286.ch4.

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James, Paula, and David Lillicrap. "Molecular Diagnostic Approaches to Hemostasis." In Practical Hemostasis and Thrombosis, 27–41. Chichester, UK: John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781118344729.ch3.

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Rauber, K., and W. S. Rau. "Diagnostik der arteriellen Thrombose und Embolie." In Hämostaseologie, 593–600. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-662-07673-6_82.

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Wermke, Wolfram, and Bernhard Gaßmann. "Thrombosed Cavernous Haemangioma." In Tumour Diagnostics of the Liver with Echo Enhancers, 46–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-46873-5_8.

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Bousser, Marie-Germaine, Colette Goujon, Valeria Ribeiro, and Jacques Chiras. "Diagnostic Strategies in Cerebral Sinus Vein Thrombosis." In Cerebral Sinus Thrombosis, 187–99. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-8199-0_17.

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Turmel-Rodrigues, Luc, and Claude J. Renaud. "Treatment of Thrombosed Accesses." In Diagnostic and Interventional Radiology of Arteriovenous Accesses for Hemodialysis, 155–95. Paris: Springer Paris, 2012. http://dx.doi.org/10.1007/978-2-8178-0366-1_12.

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Wermke, Wolfram, and Bernhard Gaßmann. "Partially Thrombosed Cavernous Haemangioma." In Tumour Diagnostics of the Liver with Echo Enhancers, 37–45. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-46873-5_7.

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Varughese, Cyril, Ajith P. Nair, and Jordan Chaisson. "Diagnosis of Device Thrombosis." In Mechanical Circulatory Support for Advanced Heart Failure, 191–97. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-65364-8_12.

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Conference papers on the topic "Thrombose – Diagnostic"

1

Krahenbuhl, B., E. Sheybani, and H. Bounameaux. "ASSESSMENT OF DIAGNOSIS OF DEEP VENOUS THROMBOSIS OF THE LOWER LIMBS USING ESTIMATION OF CLINICAL PROBABILITY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644196.

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The value of a diagnostic test (or test combination) depends not only on its sensitivity and specificity but also on the prevalence of the disease. In the present study, we have re-assessed the value of the clinical diagnosis in a group of 45 consecutive patients suspected of deep venous thrombosis (DVT) of the lower limbs. The clinical probability (CP) of the diagnosis was estimated on a clinical basis alone (history and clinical examination) by trained physicians (2-month training in an Angiology Unit). Afterwards, the diagnosis of DVT was established using the combination of Doppler ultrasounds and venous occlusive plethysmography. Venography was performed when the non invasive techniques were inconclusive.DVT was found in 14 patients (31 %). In the 21 patients in whom CP was ⩽ 0.20, there was no DVT. In the 10 patients in whom CP was ⩾ 0.80, DVT was confirmed in 9 cases. When CP was between 0.21 and 0.79, a DVT was found in 5 out of 14 patients.Thus, when CP is ⩾ 0.80 or ⩽ 0.20, further investigation does not seem to provide additional diagnostic information. The estimation of CP by a trained physician allows to define a subgroup of patients in whom the clinical diagnosis is valuable.Two third of the patients in our series belong to this subgroup. In one third of the patients, CP was intermediate and non invasive tests or venography are necessary.Since the range of clinical probability in which clinical diagnosis is reliable will depend on both the physician and the recruitment of the patients (medical or surgical, ambulatory or hospitalized), it must be determined in each center.

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ten Cate, J. W., M. V. Huisman, and H. R. Buller. "DIAGNOSIS OF DEEP VENOUS THROMBOSIS: NON-INVASIVE VS INVASIVE DIAGNOSTIC PROCEDURES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642967.

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The clinical diagnosis of deep vein thrombosis (DVT) in symptomatic patients is unreliable. The need for objective diagnostic tests is widely acknowledged. Contrast venography in experienced hands is considered to be the reference method. This method is invasive, uncomfortable to the patient, not easily repeatable and expensive.For this reason several non-invasive tests have been developed and evaluated recently. Of the non-invasive tests impedance plethysmography (IPG) has been thoroughly evaluated in properly designed prospective clinical trials. Serial IPG in symptomatic outpatients is safe and effective. It was shown in longterm follow-up that anticoagulant treatment could be safely withheld in over 500 patients with repeatedly normal IPG (0.3-0.6% recurrence DVT). The specificity for proximal DVT was 92%. The feasability of IPG in symptomatic outpatients was over 95%. The safety of withholding anticoagulant treatment in symptomatic inpatients with a serial normal IPG is an unresolved issue. Preliminary results show that a similar sensitivity might be obtained in inpatients, however, the feasability was lower (87%).Doppler ultrasound has been studied extensively, however, there is a great variation in reported sensitivity for proximal DVT due to the lack of objective diagnostic criteria and the safety of withholding anticoagulant treatment in patients with serial normal Doppler tests results is not es tablished.strain gauge plethysmography has not been evaluated properly and therefore awaits further studies. 125I-fibrinogen legscanning has been shown to be sensitive for calf vein thrombosis (over 90%). In combination with IPG this method is a safe and effective alternative to venography.Radionuclide phlebography has never been evaluated in prospective clinical trials in a broad spectrum of symptomatic patients, and can therefore not be recommended for routine use.It is concluded that presently the management of patients with clinically suspected DVT should be performed with the use of serial IPG, IPG in combination with 125I—fibrinogen legscanning or contrast venog raphy.

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Forestier, F., F. Daffos, C. Kaplan, and P. Champeix. "PRENATAL DIAGNOSIS OF HEMORRHAGIC DISORDERS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644270.

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Utilizing an easy and safe procedure for fetal blood sampling in utero. we have studied 123 fetuses for congenital oracquire hemorrhagic disorders.Usually, the diagnosis is performed at the 18th week of gestation. To date, no fetal less or premature labor has beenattributed to these fetal samplings. Theduration of the procedure was less than 10 minutes in 90 % of the cases. Direct blood sampling with a needle guided by ultrasound is safer for fetuses and simpler for the patients than fetoscopy. Among the 1.465 samplings the mortality rateis 0.2 %. We have established the basis values for fetal hemostasis when the samplings were performed for non hematological purpose, and could determine the fetal sex which play a role in hereditary disorders. Hemophilia A and B [92 cases]. Willebrand disease, factor XIII, V and VII deficiencies were diagnosed on the existence of a specific fetal deficit. Theknowledge of the fetal primary hemostasis let us to establish the diagnosis of May Hegglin syndrome. Gray platelet syndrome. and Glanzmann's thrombasthenia. There were no diagnostic errors. This procedure offers a new possibility of easily taking iterative samples, until the end of pregnancy, which represents a particular interest in prenatal diagnosis.

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Lillicrap, D., A. R. Giles, J. J. A. Holden, and B. N. White. "THE RELATIVE EFFICACY OF GENETIC ANALYSIS AND COAGULATION TESTING IN THE DIAGNOSIS OF CARRIERS OF HEMOPHILIA A." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644010.

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This study has assessed the relative benefits of restriction fragment length polymorphism (RFLP) linkage and coagulation testing in the diagnosis of carriers of hemophilia A. 221 samples from 55 families have been studied for intragenic and flanking RFLPs. All samples were tested for the Factor VIII intragenic Bell RFLP and for the flanking marker St 14. 83% of obligate carrier females were heterozygous at oneor both of these two polymorphicsites. However, only38% of these women were heterozygous at the intragenic site and might safely be offered prenatal diagnosis using this marker for the hemophilia mutation. Carrier diagnosis was obtained in 52% of 81 potential carriers tested. Diagnosis wasbased on intragenic RFLP information in only 48% of these cases. Genetic diagnosis was possible in 27 atrisk women from families with no prior history of hemophilia. Four of these women were diagnosed as carriers on the basis of a gross Factor VIII gene deletion and the remaining 23 women were identified as non-carriers by the Bell (11) and Stl4 (12) RFLP data. 39 women remained undiagnosed after gene analysis studies. 23 of these women were female relatives of sporadic hemophiliacs and thus RFLP segregation analysis was inappropriate. A further 9 potential carriers were undiagnosed because of homozygosity in key individuals in their families. In 31 potential carriers we have quantitated Factor VIII:C (one stage assay) and vWf:Ag (Laurell and ELISA) and derived probabilities for carrier status. In 3 women there was conflicting genetic and coagulation data. Meanwhile, in 12 undiagnosed women from sporadic families, carrier diagnostic probabilities of > 0.9 were obtained. These studies indicate that optimal carrier detection for hemophilia A requires more intragenic and closely linked RFLPs and the continuance of coagulation testing to assist women from sporadic families.

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5

Elias, A., G. Le Corff, J. L. Bouvier, Ph Villain, and A. Serradimigni. "DISCREPANCIES BETWEEN VENOGRAPHY AND REAL TIME B MODE ULTRASOUND IMAGING IN THE DIAGNOSIS OF DEEP VEIN THROMBOSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642892.

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Methods : in this prospective study, real time B Mode ultrasound imaging (USI) was compared to bilateral ascending contrast venography, double blindly, in 430 patients suspected of deep vein thrombosis (DVT) or pulmonary embolism.A complete scan of the venous system from the inferior vena cava to the calf veins, was performed with a high resolution duplex system (DIASONICS DRF 400) and coupled systematically with a C.W. Doppler examination. The results obtained by USI were thus compared to the venograms performed on a total of 854 legs.Results : there are corresponding results in 95% of the legs (808/854). If we consider venography as the standard of reference, the sensitivity of USI is 98% (325/333) and the specificity 94% (483/514). Isolated calf vein thrombosis are detected in 91% (84/92) of the legs and proximal DVT in 100% (241/241) in this series whatever the topography and the extension of the thrombosis and whatever the degree of the obstruction of the vein.Discrepancies found in 46 legs are related to :- 8 DVT located in the calf (6 in the presumed healthy leg) diagnosed only by venography.- 27 DVT (18 distal, 9 femoral or iliac) detected only by USI- 9 doubtful examinations with USI not confirmed by venography- 2 doubtful venograms with negative USI test.Comments : Calf vein thrombosis especially located in the soleal sinuses and the gastrocnemius with in most cases the direct image of the thrombus are more often detected by USI provided that the technique and the equipment are appropriate.The absence of visualisation of venous segments with venography is not specific of venous thrombosis. These veins non affected by the thrombosis are not filled by the contrast medium when located above in occluded ilio-femoral or ilio-caval junction or when they are the site of extrinsic compression. The direct image of the vein and the surrounding structures obtained with USI enhances the diagnostic sensitivity and specificity and provides precision of the exact extension of the thrombosis.Due to these differences, can venography still be considered as the standard of reference in the diagnosis of DVT and their precise localisation ?

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Cofrancesco, E., E. Poliani, M. Salvatore, C. Boschetti, G. Moreo, and M. Cortellaro. "ALPHA-2-ANTIPLASMIN (α2AP) IN ACUTE NONLYMPHOBLASTIC LEUKAEMIA AS A MARKER OF DISEASE ACTIVITY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643205.

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α2AP (Coatest Antiplasmin Kit, Ortho Diagnostic Systems), antithrombin III (Atlll, Coatest Antithrombin Kit, Ortho Diagnostic Systems) and plasminogen (S2251) were assayed in 21 patients with acute nonlymphoblastic leukaemia (ANLL: 5M2 5M4 5M5) before and after chemotherapy and during bone marrow cellularity recovery. The aim of the work was to investigated disturbances of coagulation and fibrinolysis with special reference to proteases inhibitors and to evaluate the prognostic value of changes in these parameters in ANLL patients. Low α2AP levels were observed in the initial phase of the disease: Ul.5 ± 2k.79 SD in 10 DIC patients versus 6U.10 !± 20.70 SD in patients without DIC (p < 0.05). α2AP normalized only in the 11 patients who achieved haematological remission (71.63 ± 13.13 SD) and remained low in those who did not respond to chemotherapy (6l.88 ± 17.86 SD, p < 0.01). No significant modification of Atlll and plasminogen levels were observed during the course of the illness.It may be postulated that proteolytic cleavage of α2AP by granulocyte proteases contributes to the low levels of the inhibitor in ANLL, and suggested that α2AP may represent a marker of leu-kaemic disease activity. In fact the mean α2AP level of all patients at diagnosis plus those who did not respond to chemotherapy was significantly lower than that of patients in haematological remission (55.93 ± 23.13 versus 71.63 ± 13.13, p < 0.05).

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Roussi, J. H., D. Francois, J. Delemme, and A. F. Goguel. "USE OF INR FOR THE EXPRESSION OF PT IN PATIENTS UNDER ORAL ANTICOAGULANTS : COMPARISON OF RESULTS OBTAINED WITH FIVE THROMBOPLASTINS AND THREE DEVICES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643881.

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The aim of our study is to know if INR (International Normalized Ratio) is really the best way to express PT (Prothrombin Time) in patients under oral anticoagulants (AVK). In this way, PT of 85 patients treated by AVK and 30 normal controls were determined with 5 different reagents and three devices : manual technic, KC10 (AHS Dade), Coag A Pet 200 (Gal Diagnostics, Organon). The reagents were : Thromborel S (Behring) extracted from human placenta, Thrombotest (Nyegaard) from ox brain, and 3 rabbit thromboplastins : Neo-plastine (Diagnostica Stago), Thromboplastine calcique (Bio-Merieux), Simplastin + (Gal Diagnostics). The results are expressed in seconds, percentage according to the dilution curve and INR with ISI given by the manufacturers.Analysis of results shows :- Influence of the technic : Whatever the technic is, mean results obtained with the same reagent, expressed in % are very close ; expressed in INR mean results are dispersed with all the reagents, ex :- Influence of the reagent : Results performed with the same technic whatever the reagent is expressed in INR are very close, whereas in % the dispersion is large.Analysis of variance and Student test show highly significant differences between all reagents for expression in %, whe reas expressed in INR (KC10) the difference is not statistical ly significant.INR leads an improvement in the dispersion of results but it seems necessary to have at least two ISI for each reagent, one determined by manual technic or device like KC10, the other one determined on photo-optical device.

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Saleh, A. A., A. M. Farag, S. F. Bottoms, E. F. Mammen, M. Hosni, and A. Ali. "SELECTED HEMOSTASIS PARAMETERS IN PREGNANCY AND HYPERTENSION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644284.

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Patients with preeclampsia are believed to have a state of compensated DIC, and especially the differential diagnosis between preeclampsia and chronic hypertension with pregnancy can be difficult. Selected hemostasis parameters were analyzed in 50 women with preeclampsia (P), 50 matched normal pregnant women (N), 14 women with known hypertensionand pregnancy (CH) and 13 persons with known chronic hypertension and superimposed preeclampsia (CH + P). None of the patients had clinical evidence of DIC. Platelet counts, mean platelet volume, antithrombin III, α2 antiplasmin and fibrinogen activities and fibronectin were assayed. The following data wereThese data, together with higherlevels of fibrinopeptide A, platelet factor 4, 3 thromboglobulin and D-dimer in the P group suggests increased intravascular coagulation in preeclampsia. Fibronectin levels were markedly elevated only in the patient groups with preeclampsia. Discriminant function analysis of FN values between the groups revealed a78% diagnostic accuracy for Palone and 74% accuracy for CH + P

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Yamazaki, Hiroyuki, Ryo Kosaka, Osamu Maruyama, Daisuke Sakota, Tatsuki Fujiwara, Katsuhiro Ohuchi, and Katsuyuki Kuwana. "Development of real-time and quantitative monitoring of thrombus formation in an extracorporeal centrifugal blood pump." In Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics, edited by Gerard L. Coté. SPIE, 2018. http://dx.doi.org/10.1117/12.2288149.

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Vigh, Zs, and I. Scharrer. "INVESTIGATIONS ON MULTIMERIC STRUCTURE OF PLATELET VON WILLE-BRAND FACTOR IN PATIENTS WITH HEREDITARY DISORDERS OF PLATELET FUNCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644087.

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Von Willebrand factor (vWF), a multimeric glycoprotein, plays an essential and multifunctional role in the hemostatic process. It is well known that platelet glycoproteins IB, IIB and IIIA contain receptors for vWF. Von Willebrand factor was also found in alpha granules of platelets. Therefore we investigated the multimeric structure of platelet vWF in 12 patients with different inherited disorders of platelet function. The patients had the following diagnosis: Hermansky Pudlak syndrome, Thrombasthenia and up to new undefined hereditary disorders of platelet function. The method is based upon:1) washing of platelets 2) release of platelet vWF 3) separation of vWF multimers by SDS-agarose electrophoresis 4) subsequent blotting of vWF mul timers onto nitrocellulose 5) staining by peroxidase conjugated antibodies.The investigations were repeated 3 times and compared to those of normal platelets. In 2 patients with Hermansky-Pudlak syndrane no multimeric structure could be detected in platelets whereas the multimeric pattern of plasma of these patients was normal. Also in one patient with the tentative diagnosis: thrombasthenia we couldn't find any multimeric structure in platelets compared to the normal multimeric composition of plasma. In 2 patients with giant platelets the multimeric distribution was normal. In the remaining 6 patients we observed multimeric structure which was different from that seen in vWd variants and in healthy volunteers. In 1 patient we found normal multimeric pattern in plasma and platelets.Based on our findings it can be assumed that the analysis of multimeric structure of platelet vWF can be helpful for the diagnostic approach and for the insight in pathogenesis of inherited disorders of platelet function.

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