Dissertations / Theses: 'Thrombose – Diagnostic'

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ROUILLARD, PHILIPPE. "Apport de l'irm au diagnostic des thromboses veineuses cerebrales." Lille 2, 1991. http://www.theses.fr/1991LIL2M284.

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Chebil, Syrine. "Elaboration de nouveaux biocapteurs électrochimiques pour le diagnostic de la thrombose veineuse profonde." Paris 11, 2010. http://www.theses.fr/2010PA112175.

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La thrombose veineuse profonde (TVP) comme sous le nom de phlébite correspond à la formation d'un caillot sanguin dans une veine. C'est une pathologie fréquente en Europe et elle reste très difficile à diagnostiquer jusqu'à présent. Ce travail qui rentre dans le cadre d'un projet Européen STREP C] consiste à élaborer un biomatériau en tant qu'outil de diagnostic de la thrombose permettant une mesure en temps réel de la présence de la maladie dans le sang du patient. La détection est réalisée par dosage de la glycoprotéine D-Dimère présente lors de la formation d'un thrombus. L'approche qui a été envisagée dans cette étude est celle de l'immobilisation de l'anticorps anti-D-Dimère tagué Histidine sur un matériau polymérique conducteur fonctionnalisé par un complexe métallique. Cette stratégie originale de la construction de l'immunocapteur réalisée étape par étape a permis à la fois d'avoir une fixation orientée de l'anticorps et de suivre la variation du signal électrochimique via le métal utilisé en tant que sonde redox. De ce fait un biocapteur a été développé à base de polypyrrole fonctionnalisé par le complexe métallique Acide NitrilotriacétiquelMétal ionique (NT AJCu2+) et a été intégré par la suite dans un dispositif miniaturisé conçu pour être fiable, précis, portatif, automatisé et économique. L'étude de stabilité dans le temps de ce biomatériau a permis la réalisation d'une nouvelle matrice d'immobilisation de l'anticorps anti-D-Dimère en utilisant un nouveau ligand enPI2 constitué par des groupements amines comms pour une très bonne chélation du cuivre II. La conception du biocapteur sur des nanomatériaux tels que les nanotubes de carbone et les nanoparticules d'or a montré une augmentation de la gamme de détection du D-Dimère. La caractérisation de ces biomatériaux et le suivi du D-Dimère ont nécessité l'utilisation de différentes techniques d'analyses électrochimique et de surface tels que la voltammétrie cyclique (CV), la DPV, la spectroscopie d'impédance électrochimique (SIE), la microscopie à force atomique (AFM), la résonance des plasmons de surface (SPR), L'infrarouge à transformée de Fourrier (FTIR), la spectroscopie des photoélectrons X (XPS) et la résonance magnétique nucléaire (RPE). L'intégration du biocapteur dans la cartouche DVT-IMP comprenant une puce et un corps micro fluidique a permis l'amplification du signal électrochimique notamment de la sonde redox grâce à l'utilisation des élecctrodes interdigitées (EIDs)
Deep vein thrombosis (DVT) known as phlebitis corresponds to the formation of a blood clot in a vein. It is a common disorder in Europe and it remains very difficult to diagnose until now. This work within the framework of a European project STREP [] is to develop a biomaterial as a tool for diagnosis of thrombosis allowing real-time measurement of the presence of the disease in the patient's blood. Detection is perfonned by assaying the glycoprotein D-dimer present during the formation of a thrombus. The approach which has been chosen in this study is the immobilization of an Histidine tagged anti-D-Dimer on a conductive polymer material functionalized with a metal complex. This original strategy for the construction of the immunosensor has been achieved step by step allowed both to have an oriented attachment of the antibody and monitor the change in electrochemical signal through the metal used as a redox probe. Thus a biosensor based on polypyrrole functionalized with nitrilotriacetic acid metal complex (NT AJCu2 +) was developed and was subsequently incorporated into a miniaturized device designed to be reliable, accurate, portable, automated and economical. The study of the biomaterial time stability has enabled the creation of a new matrix for the anti-D-dimer immobilization using a new ligand enPI2 containing amine groups known for a very good Copper II chelation. The design of the biosensor on nanomaterials such as carbon nanotubes and gold nanoparticles showed an increase in the D-dimer detection range. The characterization of these biomaterials and the D-dimer monitoring required the use of different electrochemical and surface analytical techniques such as cyclic voltammetry (CV), DifferentiaI Pulse Voltammetry (DPV), the electrochemical impedance spectroscopy (EIS), the Atomic force microscopy (AFM), the surface plasmon resonance (SPR), The Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS) and nuclear paramagnetic resonance (EPR). The integration of the biosensor in the DVT-IMP cartridge comprising a chip and a microfluidic body allowed the amplification of the electrochemical signal including the redox probe through the use of interdigitated élecctrodes (EIDs)

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3

PUMO, JEAN-FRANCOIS. "Diagnostic radiologique des thromboses veineuses portales : a propos de 45 cas." Nice, 1994. http://www.theses.fr/1994NICE6520.

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4

Marty, Dominique. "Diagnostic et traitement des thromboses veineuses profondes chez la femme enceinte : a propos de deux cas." Toulouse 3, 1992. http://www.theses.fr/1992TOU31072.

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5

Jacobin-Valat, Marie-Josée. "Nouvelles perspectives pour le diagnostic et la thérapie des pathologies myocardiques et thrombotiques : obtention d'anticorps monoclonaux humains recombinants." Bordeaux 2, 2001. http://www.theses.fr/2001BOR28853.

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Le suivi immunoscintigraphique des pathologies myocardiques et le traitement des pathologies coronariennes nécessitent le développement de nouvelles sondes injectables à l'homme sans danger. D'où notre intérêt pour les AcM. Ainsi l'IgM humaine B7 anti-myosine obtenue par l'équipe de recherche, présente un potentiel dans la détection des nécroses myocardiques et le diagnostic précoce d'éventuels rejets de greffe. Les applications cliniques nécessitant une clairance et une pénétration tissulaire optimum, des fragments scFv ont été élaborés par ingénierie moléculaire. Dans le cadre des pathologies coronariennes, les antagonistes de l'intégrine αIIbβ3 ont suscité l'intérêt en tant qu'outil de diagnostic et de thérapie des thromboses. L'AcM murin XIIF9 spécifique de la conformation de l'αIIbβ3 exprimée sur les plaquettes activées, présente une bonne fixation ex vivo des thrombi sur un modèle animal de l'athérosclérose. Les antagonistes, en inhibant la formation du complexe αIIbβ3 /fibrinogène, réduisent les épisodes thrombotiques chez les patients à risque. Trois banques combinatoires humaines d'anticorps ont été développées à partir des cellules B de patients immunisés contre l'intégrine αIIbβ3 lors de pathologies telles la Thrombasthénie de Glanzmann (EB) ou le Purpura Thrombopénique AutoImmun (TE et BO). Des phages-anticorps recombinants spécifiques de l'intégrine sous sa conformation activée, ont été isolés selon la méthode d'expression de fragments d'anticorps à la surface de phages filamenteux. Notre étude a montré la nature polyclonale de la réponse immunitaire développée, la pathogénicité des auto-anticorps déterminée par l'accumulation de mutations au niveau des régions CDRS et l'émergence de motifs récurrents au niveau des CDR3H. De plus, le potentiel d'inhibition de l'agrégation plaquettaire des formes solubles scFv de certains clones a été clairement démontré lors d'études d'affinité et d'inhibition par le fibrinogène
Scintigraphic studies of myocardial pathologies and the treament of Acute Coronary Syndrome (ACS) show the necessity to obtain a new class of agents that could be injected in humans without provoking the immune system. It's the reason why we chose to study the diagnostic and therapeutic potential of human mAbs. The ability of a monospecific human IgM Mab (B7) obtained by the research team, to bind to human heart myosin suggests that this mAb may be useful in the imaging of mycordial necrosis after myocarditis of graft rejection. Owing to the fact that the parent molecule is an IgM, the scFv fragment were constructed by molecular ingineering to alleviate problems such as a poor diffusion and a slow penetration inside necrotic myocytes. For a purpose of detection of newly formed thrombi, we determined the feasibility of imaging thrombi using a 123-I labeled murine Mab XIIF9 in an atherosclerotic rabbit model of acute arterial thrombosis. This Mab presented with high affinity and specificity for αIIbβ3 expressed on activated platelets holds promise for ACS imaging. Moreover, we have made a great deal of efforts towards developping αIIbβ3 inhibitors that block fibrinogen inducing platelet aggregation and have a more significant impact for therapeutic management of patients with ACS than currently used αIIbβ3 antagonists. We have succeeded in generating three libraries of single-chain antibodies (TE, EB and BO) from the B cells of patients with Glanzmann's Thrombasthenia or AutoimmuneThrombocytopenic Purpura developing in their sera antibodies against the αIIbβ3 integrin. We obtained several specific recombinant phage-antibodies stemmed from studied patients by phage display of single-chain antibodies on the surface of filamentous phage, some of them recognising the activated form of the integrin. A first important conclusion issuing from our results is that the immune reaction occurring during these diseases consists of a polyclonal hypermutations displayed in the complementarity-determining regions by anti-αIIbβ3 fragments supports the hypothesis of the pathogenesis of developing antibodies. Thirdly, CDR3H analysis of phage-antibodies points out recurrent patterns. Affinity studies and assays for inhibition of platelet aggregation clearly show the therapeutic potential of some of these recombinant antibodies

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Le, Bouffant Françoise. "Le lupus anticoagulant : recherche d'une corrélation entre les différents tests biologiques permettant le diagnostic." Bordeaux 2, 1992. http://www.theses.fr/1992BOR2P057.

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Terral, Christophe. "Thromboses veineuses profondes révélatrices de cancers : à propos de 6 cas." Montpellier 1, 1992. http://www.theses.fr/1992MON11031.

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8

BOUHET, CUCHE ANNE. "Interet de l'echographie couplee au doppler pulse avec codage couleur dans le diagnostic des thromboses portales recentes chez l'adulte." Besançon, 1991. http://www.theses.fr/1991BESA3063.

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9

EL, ALAMI PAYELLE NATHALIE. "Dosage des d. Dimeres en urgence : interet dans le diagnostic de la maladie veineuse thrombo-embolique." Rennes 1, 1992. http://www.theses.fr/1992REN1M033.

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10

Pometan, Bruno. "Ischémie aigue distale du membre supérieur au cours de la pratique sportive : à propos de deux cas." Bordeaux 2, 1999. http://www.theses.fr/1999BOR2M092.

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11

Debost, Sabine. "Dosage fonctionnel de la protéine C avec activation par le complexe thrombine-thrombomoduline : application à la caractérisation de variants moléculaires." Paris 5, 1994. http://www.theses.fr/1994PA05P002.

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12

Bijaoui, Alexandra. "Intérêt du dosage des D-dimères dans le diagnostic de la maladie thromboembolique." Paris 5, 1998. http://www.theses.fr/1998PA05P126.

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13

Achard-Lichere, Cécile. "Phlébographie par résonance magnétique indépendante du flux : techniques et perspectives dans le diagnostic non-invasif des thromboses veineuses profondes." Montpellier 1, 1999. http://www.theses.fr/1999MON11094.

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14

LISIECKI, SYLVIE. "Interet de l'echo-doppler couleur dans le diagnostic et la surveillance au cours du premier mois des thromboses veineuses profondes des membres." Amiens, 1992. http://www.theses.fr/1992AMIEM012.

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15

Mathelié-Guinlet, Rousseau Nathalie. "Le doppler couleur dans le diagnostic des thromboses veineuses profondes des membres inférieurs." Bordeaux 2, 1993. http://www.theses.fr/1993BOR2M175.

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16

Rabhi, Yahya Abdelwahab. "Echogénicité spontanée du sang circulant : echogénicité et échostructure du thrombus, vers une approche objective et quantitative." Tours, 2001. http://www.theses.fr/2001TOUR3307.

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Sur les images échographiques des vaisseaux, le sang n'est normalement pas visible. La stase, mais aussi des perturbations biologiques ou rhéologiques traduisant un risque thrombotique, peuvent rendre échogènes les agrégats érythrocytaires ou plaquettaires. L'aspect échographique du thrombus est variable selon ses conditions et sites de constitution, et son étiologie. Le but de cette thèse était donc de contribuer à l'élaboration d'un outil automatique de quantification de l'échogénicité et d'analyse de l'échostructure. Cette thèse fait d'abord le point des connaissances relatives à la diffusion des ultrasons par les agrégats et à la relation entre les déterminants géométriques et physiques des agrégats et l'échogénicité du sang. Nous avons calculé un ensemble de paramètres objectifs de premier et second ordre sur un thésaurus d'images de veines présentant des degrés divers d'échogénicité du sang, et les avons comparés aux scores subjectifs attribués par deux experts indépendants. La reproductibilité inter-observateur de l'analyse subjective s'est avérée médiocre, tandis que le taux d'échogénicité relative s'est avéré le paramètre calculé le plus discriminant. La reconnaissance automatique du thrombus sur l'image échographique a ensuite été abordée par les techniques de segmentation d'images, et le modèle des régions actives géodésiques a été développé et mis en oeuvre par les ensembles de niveaux. Les premiers tests ont montré sa capacité à déterminer les contours du thrombus. Les développements ultérieurs visent à affiner cette délimitation et la rendre possible sur les séquences dynamiques. Les outils ainsi élaborés devraient permettre la réalisation d'études prospectives pour évaluer la signification clinique de l'échogénicité du sang en regard du risque thrombotique, ainsi que la caractérisation du thrombus pour son diagnostic étiologique, sa datation et le suivi de son évolution sous traitement.

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ELIAS, DAOUD MARIE. "Valeur comparee du dosage plasmatique des d-dimeres et de l'echographie-doppler dans le diagnostic des thromboses veineuses des membres inferieurs." Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20053.

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Le, Jeune Sylvain Hamidou Mohamed. "Spécificités des thromboses veineuses digestives associées aux syndromes myéloprolifératifs résultats d'une étude rétrospective de 86 cas /." [S.l.] : [s.n.], 2008. http://castore.univ-nantes.fr/castore/GetOAIRef?idDoc=49111.

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BENDAYAN, PIERRE. "Rapport cout - efficacite du tandem echographie duplex plethysmographie dans le diagnostic des thromboses veineuses profondes des membres inferieurs ; etude prospective a propos de 511 patients." Toulouse 3, 1990. http://www.theses.fr/1990TOU31514.

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Mahou, Alain. "Thromboses veineuses profondes survenant chez des personnes âgées hospitalisées : évaluation du dosage des D-dimères comme test diagnostic d'exclusion." Bordeaux 2, 1998. http://www.theses.fr/1998BOR2M116.

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FLEURET, ANTOINE. "Valeur du dosage des produits de degradation de la fibrine (les d-dimeres) dans le diagnostic des thromboses veineuses profondes : comparaison de plusieurs techniques." Amiens, 1990. http://www.theses.fr/1990AMIEM098.

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22

Le, Bolzer Hélène Trossaërt Marc. "Intérêt du suivi des D-dimères pour le diagnostic de thrombose au cours du traitement par L-asparaginase des LAL de l'enfant." [S.l.] : [s.n.], 2004. http://theses.univ-nantes.fr/thesemed/PHlebolzerh.pdf.

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GILLARD, GIGANDET SYLVIE. "Le diagnostic echographique des thromboses veineuses des membres inferieurs : comparaison entre l'echographie couplee au doppler pulse et au doppler couleur et la phlebographie : etude prospective d'une serie de 40 cas." Besançon, 1990. http://www.theses.fr/1990BESA3077.

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Rey, Emmanuelle. "Diagnostic de la résistance à la protéine C activée : méthodes et limites." Bordeaux 2, 1997. http://www.theses.fr/1997BOR2P076.

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Deye, Brigitte. "Etude comparée échographie - Doppler par rapport à la phlébographie dans le diagnostic des thromboses veineuses profondes des membres inférieurs." Montpellier 1, 1988. http://www.theses.fr/1988MON11259.

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BOURIEZ, EDMONDE. "Interet du couplage du doppler continu et de l'echographie en temps reel dans le diagnostic des thromboses veineuses profondes des membres inferieurs par comparaison a la phlebographie : a propos de 24 observations." Lille 2, 1989. http://www.theses.fr/1989LIL2M246.

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Catrin, Benoit. "Etude de l'interêt du dosage des D. Dimeres dans le diagnostic précoce des T. V. P. En unité de long séjour : étude prospective." Bordeaux 2, 1993. http://www.theses.fr/1993BOR2M208.

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Gkanatsas, Yannik Andreas [Verfasser], and Thomas [Akademischer Betreuer] Eschenhagen. "Thrombus-Targeted Theranostic Microbubbles for Simultaneous Ultrasound Diagnosis and Therapy of Thrombosis / Yannik Andreas Gkanatsas ; Betreuer: Thomas Eschenhagen." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2018. http://d-nb.info/1156462320/34.

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Sirol, Marc. "Caractérisation de l'athérothrombose en imagerie par résonance magnétique : rôle de l'imagerie moléculaire pour l'évaluation de la plaque vulnérable." Paris 7, 2007. http://www.theses.fr/2007PA077177.

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Les complications thrombotiques de la maladie athéromateuse représentent la première cause de mortalité dans les pays développés. L'IBM de haute résolution est devenue depuis peu l'une des modalités d'imagerie les plus prometteuses pour l'évaluation non invasive de l'athérothrombose. Elle a le potentiel de détecter et de caractériser les différents composants de la plaque d'athérome. L'imagerie moléculaire utilise des agents de contraste spécifiques des composants de la plaque, ayant une forte affinité pour une activité biologique. Au cours de notre travail, nous avons démontré les bénéfices de l'imagerie moléculaire par rapport à l'IRM de haute résolution. D'une part, la détection du thrombus est facilitée par l'injection d'un agent de contraste spécifique de la fibrine (EP-2104R) sur un modèle animal de thrombose carotidienne. D'autre part, l'IRM est facilitée par le Gadofluorine pour la détection et la caractérisation, du contenu en lipides et de la densité en néovaisseaux des plaques d'athérome avancées. L'imagerie moléculaire, fournit des informations déterminantes sur la présence d'une molécule clé de la vulnérabilité de la plaque in vivo. Elle permet en outre le dépistage des plaques d'athérome à un stade très précoce de leur formation. Cette technique appliquée à l'homme sera d'un apport diagnostique majeur. Elle devrait permettre d'identifier les patients à risque, offrant ainsi la possibilité d'une intervention thérapeutique préventive. De plus, l'imagerie moléculaire en IRM aidera à améliorer la stratification du risque des patients, en identifiant localement de manière fiable les plaques « actives », considérées comme instables
Despite advances in our understanding of the pathogenesis of atherosclerosis and its thrombotic complications remain the leading cause of mortality in Western societies. Identification of high-risk atherosclerotic lesions prone to rupture and thrombosis may greatly decrease the morbidity and mortality associated with atherosclerosis. High-resolution MRI has recently emerged as one of the most promising techniques for the non-invasive study of atherothrombotic disease, as it can characterize plaque composition and monitor its progression. The development of MRI contrast agents that specifically target components of the atherosclerotic plaque may enable non-invasive detection of high-risk lesions. This research focuses on the use of molecular imaging for the identification of high risk or vulnerable plaques in vivo. We demonstrated the ability of fibrin-targeted MR contrast agent (EP-2104R) for detection and age determination of carotid thrombus. In addition, Gadofluorine-enhanced MRI demonstrated its ability of identifying lipid-rich plaques as well as neovessel high density areas in vivo. We established the superiority of molecular imaging compared to high resolution MRI or contrast-enhanced MRI for plaque characterization. This technique allow for allow the identification of high-risk atherosclerotic lesions in-vivo, using a variety of molecules present in atherosclerotic plaques that may serve as targets for specific contrast agents. Ultimately, such agents may enable treatment of "high-risk" patients prior to lesion progression and occurrence of complications, and may allow for better stratification of "high-risk" plaque and "high-risk" patients

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Baarslag, Hendrik Jan. "Diagnosis and management of upper extremity deep vein thrombosis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/86567.

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Brock, Sheila Anne. "Compression and Doppler ultrasound of deep vein thrombosis in patients on tuberculosis treatment." Thesis, Cape Peninsula University of Technology, 2013. http://hdl.handle.net/20.500.11838/1570.

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Thesis submitted in fulfilment of the requirements for the degree of Doctor of Technology: Radiography in the Faculty of Health and Wellness Sciences at the Cape Peninsula University of Technology 2013
Background. Ultrasound has until recently been regarded as a sophisticated examination reserved for tertiary health care. In reality it is well suited to the district or primary health-care situation. A DVT (deep vein thrombosis) is an important complication of the treatment of TB and this can lead to more devastating sequelae such as a pulmonary embolus. Many DVTs are clinically silent, making the diagnosis difficult. Method. This study was a prospective, longitudinal observational study. The study documented the incidence of DVTs and their onset, assessed certain aspects in an attempt to identify some risk factors, and noted the most common position of the DVT in a TB population. The feasibility of a sonographer-led ultrasound clinic for the diagnosis of DVTs was also assessed. This was achieved by screening the in-patient population at a district TB hospital. The participants received up to four routine duplex Doppler compression ultrasound examinations of the venous system of the lower extremities on week 0, week 4, week 8 and week 14. In addition a single abdominal ultrasound was performed at week 0. Results The incidence of DVTs in this TB population was 15.3%. A median of day 10 from commencing TB treatment was identified as the most common day to develop a DVT. The popliteal vein was the most frequent position for a DVT. Several statistically significant factors were identified, including a decreased ambulatory status, TB regimen and the use of anticoagulants. Only 52% of the DVTs were clinically symptomatic. The clinical evaluation for a DVT diagnosis in this study population had a sensitivity of 52.4% and a specificity of 65.3%. The positive predictive value (PPV) was 21.7%. Of the abdominal ultrasound reports there were 75.5% (281) abnormal reports, 22.5% (n = 90) normal reports and 4.5% (n = 18) with no report. Conclusion This body of work has shown how an effective ultrasound service can be provided at a district level TB hospital successfully administered by a trained ultrasonographer. This also facilitated a screening service to diagnose both symptomatic and asymptomatic deep vein thromboses in newly diagnosed tuberculosis patients. This study confirmed a higher rate of DVT in newly diagnosed TB patients than has been previously seen. It also provided detail on additional risk factors. The study illustrates the poor performance of clinical signs and symptoms as a trigger for further investigation for the confirmation of a DVT. Given the frequency and impact of the embolic complications of DVT, this study provides a strong justification for further research into routine serial ultrasonic screening and/or prophylactic antithrombolytics in newly diagnosed TB patients. As well as the DVT ultrasound scans there was the ancillary service offered by the research sonographers. This included an abdominal scan that detected abdominal pathology in 75% of the scans performed. An ultrasound scan is not pathognomonic but it does provide significant insight into the extent of some of the abdominal pathologies seen in TB patients. The information provided from this study gives a good indication of the problem that DVTs present in this population and the complexities of the disease TB. It is hoped that the results from this study will better equip the medical team in the non-tertiary situation to be vigilant for the presence of a DVT and educate them on the usefulness of the ultrasound scan.

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Lapidus, Lasse. "Thromboembolism following orthopaedic surgery : outcome and diagnostic procedures after prophylaxis in lower limb injuries /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-111-1/.

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33

Cate-Hoek, Arina Janna ten. "New developments in diagnosis and treatment of deep vein thrombosis." [Maastricht] : Maastricht : [Maastricht University] ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=13095.

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34

Lafargue, Frédérique. "Evaluation d'une nouvelle méthode de dosage de D. Dimères et intérêt dans le dépistage de l'embolie pulmonaire et des thromboses veineuses profondes." Bordeaux 2, 1996. http://www.theses.fr/1996BOR2P045.

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35

Aronen, Hannu J. "Imaging methods in the diagnosis of suspected deep venous thrombosis of the leg." Hki : Societas scientiarum Fennica, 1989. http://catalog.hathitrust.org/api/volumes/oclc/57854420.html.

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36

Guerrero, Julian. "System for vessel characterization : development and evaluation with application to deep vein thrombosis diagnosis." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1558.

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A system for vessel characterization aimed at detecting deep vein thrombosis (DVT) in the lower limbs has been developed and evaluated using ultrasound image processing, location and force sensors measurements, blood flow information and a protocol based on the current clinical standard, compression ultrasound. The goal is to provide an objective and repeatable system to measure DVT in a rapid and standardized manner, as this has been suggested in the literature as an approach to improve overall detection of the disease. The system uses a spatial Kalman filter-based algorithm with an elliptical model in the measurement equation to detect vessel contours in transverse ultrasound images and estimate ellipse parameters, and temporal constant velocity Kalman filters for tracking vessel location in real-time. The vessel characterization also comprises building a 3-D vessel model and performing compression and blood flow assessments to calculate measures that indicate the possibility of DVT in a vessel. A user interface designed for assessing a vessel for DVT was also developed. The system and components were implemented and tested in simulations, laboratory settings, and clinical settings. Contour detection results are good, with mean and rms errors ranging from 1.47-3.64 and 3.69-9.67 pixels, respectively, in simulated and patient images, and parameter estimation errors of 5%. Experiments showed errors of 3-5 pixels for the tracking approaches. The measures for DVT were evaluated, independently and integrated in the system. The complete system was evaluated, with sensitivity of 67-100% and specificity of 50-89.5%. System learnability and memorability were evaluated in a separate user study, with good results. Contributions include a segmentation approach using a full parameter ellipse model in an extended Kalman filter, incorporating multiple measurements, an alternate sampling method for faster parameter convergence and application-specific initialization, and a tracking approach that includes a sub-sampled sum of absolutes similarity calculation and a method to detect vessel bifurcations using flow data. Further contributions include an integrated system for DVT detection that can combine ultrasound B-mode, colour flow and elastography images for vessel characterization, a system interface design focusing on usability that was evaluated with medical professionals, and system evaluations through multiple patient studies.

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Lestage, Bruno. "Thrombomoduline, marqueur de la lésion endothéliale : étude prospective chez 36 patients atteints d'artériopathie athéromateuse." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M198.

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Wang, Yan, and 王焱. "Atherosclerotic disease of the carotid, coronary and renal arteries: diagnosis, angioplasty and the effect ofstent surface on early thrombosis and restenosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31246060.

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Ghaye, Benoît. "La Maladie thromboembolique pulmonaire aigue: diagnostic et pronostic par tomodensitométrie hélicoïdale." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209051.

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L’acquisition par MDCT et la reconstruction en coupes épaisses de 1.25 mm permettent l’analyse des artères pulmonaires jusqu’à leur 5ème ordre. L’angiographie thoracique par TDM permet de proposer des critères pronostiques de survie des patients atteints d’EP sévère. Le VD/VGd et le diamètre de la veine azygos en sont les meilleurs prédicteurs. En tenant compte de Dmax, de tmax, de l’homogénéité de l’opacification vasculaire et de la différence minimale nécessaire, le délai optimal pour l’acquisition de la vénographie par TDM se situe entre 210 et 240 sec. pour les veines infrapoplitées et entre 180 et 300 sec. pour les veines supra-poplitées. Pour une vénographie par TDM en mode séquentiel, une acquisition caudo-craniale débutant 210 sec. après l’injection du produit de contraste iodé pourrait permettre la détection optimale des caillots. En mode hélicoïdal, le sens de l’acquisition n’est pas déterminant. Malgré la possible amélioration de la détection des caillots artériels pulmonaires par MDCT, cette technique n’a pas permis de déceler plus d’EP sans TVP que le SDCT. En revanche, puisque le MDCT a permis de détecter plus de TVP sans EP que le SDCT, la vénographie par TDM en MDCT apporte une valeur ajoutée au SDCT. Par ailleurs, en MDCT, la vénographie par TDM diminue de 29% la proportion d’examens indéterminés obtenus par la seule réalisation de l’angiographie thoracique par TDM. Que ce soit en SDCT ou en MDCT, cette étude suggère l’utilité de combiner les deux examens. Chez les patients suspects d’EP, la vénographie par TDM doit s’étendre des mollets aux crêtes iliaques. Bien qu’une EP existe chez une majorité de patients atteints de TVP et vice versa, la charge en caillots dans un compartiment n’indique pas nécessairement la charge en caillots dans l’autre.
Doctorat en Sciences médicales
info:eu-repo/semantics/nonPublished

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Blecher, Gabriel E. "Diagnosing DVT in the Emergency Department: Combining Clinical Predictors, D-dimer and Bedside Ultrasound." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24003.

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I assessed the accuracy of two clinical prediction rules, the d-dimer blood test and point of care ultrasound for diagnosing lower limb deep vein thrombosis. Emergency physicians were trained in ultrasound and prospectively scanned emergency department patients with suspected deep vein thrombosis. Accuracy of the Wells and AMUSE rules and the ultrasound result was compared to radiology-performed ultrasound and a 90-day clinical outcome. Univariate and multivariate analyses were performed assessing which factors were associated with the outcome. The sensitivity and specificity of the Wells score for the clinical outcome was 85.7% and 68.5%; the AMUSE score 85.7% and 54.4%. Ultrasound had a sensitivity of 91.7% and specificity of 91.7% for radiology-diagnosed thrombus and 78.6% and 95.0% for clinical outcome. The odds ratio of a positive outcome with a positive ultrasound was 65.1. After receiving the ultrasound training program, emergency physicians were unable to demonstrate sufficient accuracy to replace current diagnostic strategies.

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Dufourcq, Pascale. "La thrombomoduline, un marqueur de la lésion endothéliale : approche clinique et expérimentale dans la maladie athéromateuse." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2P019.

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Edwards, David. "Pre-Clinical Evaluation of a Novel Radiotracer for the Diagnosis of DVT and Pulmonary Embolism." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7321.

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Zahid, Muhammad. "Design and Optimization of Recombinant Antibodies Directed Against Platelet Glycoprotein VI with Therapeutic and Diagnostic Potentials." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00922980.

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Human platelets glycoprotein VI (GPVI) is evidenced to be a platelet receptor of major importance in the occurrence of arterial thrombosis. Thus, it can be considered to be of great interest in diagnosis and therapeutic of atheriosclerotic diseases. Antibodies are powerful molecules which can be used in both diagnostic as well as for therapeutic purposes due to their unique characteristics. Monoclonal and recombinant antibodies have antigen restricted specificity, high affinity and can be used in various assays. Moreover, the good knowledge of their structure and molecular engineering facilities now allows the antibody modulation according to desired properties.Our group has already produced several monoclonal antibodies to human GPVI by gene gun immunization against the immunoadhesin hGPVI-Fc, which differ in fine epitopespecificity, affinity and other functional properties (Lecut et al. 2003). One, 3J24, with diagnostic potential while the other, 9O12, has a therapeutic potential because it blocks the binding of GPVI to collagen. Its Fab fragment has been extensively characterized in vitro,ex vivo and in vivo for its antithrombotic properties.Here, we designed and reshaped a single-chain antibody fragment (scFv) based on 3J24variable domains for the quantification of GPVI with diagnostic potential. We were also involved in the design, production and functional evaluation of humanized anti-GPVI recombinant antibody fragments (scFvs and Fabs) with therapeutic properties.

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Tinkler, Kerry. "Setting up, piloting, implementing and reviewing a GP direct access service for the diagnosis of lower limb deep vein thrombosis." Thesis, University of Portsmouth, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407268.

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Almeida, Maria Antônia Campos. ""Fibrinogênio como marcador de trombose"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5136/tde-15092006-141829/.

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INTRODUÇÃO: Um grande número de estudos epidemiológicos têm demonstrado que o fibrinogênio é fator de risco consistente e independente para doença cardiovascular. O fibrinogênio, além de ser um determinante de trombose arterial foi considerado fator de risco de trombose venosa. Foram avaliados os níveis plasmáticos do fibrinogênio em indivíduos que apresentaram algum tipo de trombose não influenciada por reação de fase aguda ou resposta inflamatória. MÉTODOS: Neste estudo de caso-controle realizado entre julho de 2003 a abril de 2005 foram incluídos 39 pacientes, entre 25 e 65 anos, com diagnóstico objetivamente confirmado de trombose, sem antecedentes de neoplasia e colagenose. O tempo mínimo entre a evento e a coleta da amostra de sangue foi de 6 meses. O grupo controle foi constituído de doadores e funcionários voluntários do Hemocentro Regional de Juiz de Fora. A concentração plasmática de fibrinogênio e a medida da Proteína C Reativa foram realizados nos dois grupos. RESULTADOS:Os níveis médios de fibrinogênio foram significativamente maiores nos pacientes ( 316)que no grupo controle (259), p=0,0002. a média de idade foi 48,3 para os pacientes e 45,5 para o controle. A aplicação do teste qui quadrado demonstrou que não houve diferenças significativas nos grupos de pacientes e controles (30,8% e 27%, respectivamente) em relação ao tabagismo(pvalor = 0,72). A frequência de hipertensão foi significativamente maior no grupo de pacientes (28,2%) que no controle (5,4%) (p-valor=0,008). O teste t para a diferença dos níveis médios de fibrinogênio entre os grupos de trombose venosa e arterial não apresentou resultado estatisticamente significante (p-valor = 0,69). CONCLUSÃO: Com base nos dados deste estudo, os níveis de fibrinogênio estão relacionados com trombose, independente se arterial ou venosa.
INTRODUCTION: A great number of prospective epidemiologic studies have reported that fibrinogen is consistently and independently risk factor for the cardiovascular disease. The fibrinogen, a determinant of arterial thrombosis, was also considered a risk factor for the venous thrombosis. It was valued the fibrinogen plasmatic level in patients that had showed some kind of thrombosis event without influence by acute phase reactions or ongoing inflamatory responses. METHODS: In this cases-control study, fulfilled between july 2003 and april 2005, was included 39 patients, among 25 e 65 ears, with confirmed diagnosis of thrombosis and none neoplasis and collagenosis antecedent. Six months was the minimum time between event and blood sample collect. The control group was composed by blood donor and voluntary employee of the Hemocentro Regional de Juiz de Fora. The fibrinogen plasmatic concentration and the C-reactive proteins measure was made in both groups. RESULTS: The medium levels of fibrinogen were significantly higher in patients (316) than the control group (259), p=0,0002. The age average was 48,3 for the patients and 45,5 for the control. The qui-quadrado test application proved there wasnt any significatives differences in both groups, patients (30,8%) and control (27%), in the relation with smoking (p-value = 0,72). The frequency of arterial hypertension was significantly higher in patient group (28,2%) than the control group (5,4%) (p-value = 0,008). The t-test for the differences of the fibrinogen average levels between venous and arterial thrombosis didnt present any significant statistic result. CONCLUSION: Established in this research, the higher levels of fibrinogen are associated with thrombosis, independently if arterial or venous.

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CESCA, ROBERTON NICOLE. "Interet de la rheoplethysmographie par occlusion veineuse dans le diagnostic des complications thrombo-emboliques chez le blesse medullaire : a propos de 32 patients." Angers, 1990. http://www.theses.fr/1990ANGE1114.

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Brand, Jannik [Verfasser]. "Präklinische Diagnostik und Therapie in einer Mobilen Stroke Unit zur Verkürzung der Zeit bis zur intravenösen Thrombolyse beim akuten ischämischen Schlaganfall / Jannik Brand." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1219507865/34.

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Block, Tomas. "Acute Occlusion of the Superior Mesenteric Artery : Diagnosis and treatment." Doctoral thesis, Uppsala universitet, Kärlkirurgi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130816.

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Acute occlusion of the superior mesenteric artery (SMA) is a condition associated with high mortality and morbidity. The aim of this thesis is to evaluate diagnostic and therapeutic approaches for acute SMA occlusion. In a prospective study of patients with suspected intestinal ischemia, no biomarker was sufficiently accurate to detect this condition. In a second retrospective study, pancreatic amylase and troponin-I were elevated in a substantial proportion of patients with verified SMA occlusion. In an experimental animal model of acute SMA occlusion, microarray studies of ischemic small bowel wall were used to characterize the mRNA response to ischemia. Thrombospondin, Monocyte Chemoattractant Protein 1 and Gap Junction Alpha 1 were consistently up-regulated in all pigs with intestinal ischemia. Genes encoding previously proposed biomarkers for intestinal ischemia were either up-regulated, such as lactate dehydrogenase and creatine kinase, or down-regulated, such as intestinal fatty acid binding protein and glutathione S-transferase. In a study of the role of computed tomography in the diagnosis of SMA occlusion, it was shown that computed tomography with intravenous contrast was associated with improved survival. A retrospective analysis of all acute SMA revascularizations in Sweden 1999-2006 revealed that D-dimer was elevated in all 35 measured cases. Endovascular surgery was associated with better outcome than open surgery, both in short and in long term. The presence of postoperative short bowel syndrome was a strong independent risk-factor for decreased long-term survival. Conclusions: Data affirm that D-dimer may serve as an exclusion test for acute SMA occlusion, whereas elevated troponin-I and pancreatic amylase are potential diagnostic pitfalls. Contrast-enhanced computed tomography of the visceral arteries seems to be the best diagnostic method. Endovascular surgery is an option to open surgery in selected cases, and was associated with favourable outcome.

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Dutra, Aurélio Pimenta. "Trombose venosa cerebral: evolução clínica e fatores prognósticos em 111 pacientes." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-24112008-122700/.

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Introdução: A evolução clínica da trombose venosa cerebral (TVC) pode variar desde a recuperação completa ao óbito. Séries européias e um estudo multicêntrico identificaram alguns fatores indicativos de prognóstico da TVC, dado importante na decisão da melhor terapêutica para os pacientes. Este estudo busca identificar, a partir do seguimento prospectivo de cento e onze pacientes com TVC, os fatores prognósticos envolvidos na evolução clínica durante o período de 2 anos. Pacientes Métodos: Foram acompanhados prospectivamente 111 pacientes com diagnóstico de TVC desde a fase aguda do diagnóstico, confirmado por meio de RM de encéfalo e/ou angiografia cerebral (ARM, ATC ou angiografia digital). Obtidos dados do quadro clínico e seguimento por um protocolo clínico. 96% dos pacientes foram anticoagulados na fase aguda com heparina e seguida de anticoagulação com warfarina. Submetidos a investigação para os fatores predisponentes para TVC. A evolução clínica foi quantificada por meio da escala modificada de Rankin (EMR) após 3, 6, 12 e 24 meses, definindo os pacientes de bom prognóstico EMR 1, e mau prognóstico EMR 2. Comparamos dados clínicos da fase aguda e resultados encontrados nos exames de imagem e laboratoriais como possíveis fatores prognósticos, através da análise univariada pelo teste 2 e os fatores de significância estatística (p<0,1), foram analisados com regressão logística ajustada e cálculo da razão de chances (RC), (intervalo de confiança IC=95%). Resultados: A média da idade dos pacientes foi de 35 anos, 72% mulheres, 40% afro-brasileiros. As principais manifestações clínicas foram: cefaléia 97%, déficit focal 47%, crise epiléptica 40%, alteração da consciência 28%, síndrome de HIC (SHIC) isolada 40%. Quanto aos fatores predisponentes; 75% das mulheres usavam anticoncepcional, 31% dos pacientes apresentavam trombofilia hereditária, 13% SAAF, 6% eram portadores de vasculites, 25% outros estados pro trombóticos, 7 % apresentavam fatores locais (infecciosos ou MAV); e 5% das mulheres estavam no puerpério ou gestação. Os dados de neuroimagem revelaram que 42% apresentaram trombose em mais de um sistema venoso, 33% tiveram infartos hemorrágicos e 18% infartos venosos isquêmicos, e 20% dos pacientes apresentaram trombose de veias e seios profundos. Após 24 meses 18 pacientes (17%) apresentaram EMR 2 e os fatores determinantes de pior prognóstico foram: a etnia afro-brasileira p=0,001; RC= 11,37 (95% IC 2.81- 46,08), alteração do nível de consciência p=0,007; RC=4.56 (95% IC 1.61-19.45), sexo masculino p=0,049 RC=3.55 (95% IC 1.00-12.55) e idade acima de 32 anos p=0,05 RC = 3.95 (95% IC 0,97-15.20). A presença isolada de ACO como fator predisponente está associado ao melhor prognóstico p = 0,016; RC=5,17(95% IC 1.37-19.57) e após 24 meses a mortalidade foi de 4,5%. Conclusão: A análise deste trabalho evidencia que a maioria dos pacientes portadores de TVC (83%) apresenta uma evolução benigna com o tratamento, estando após 24 meses assintomáticos ou com sintomas mínimos, e a presença de ACO como fator predisponente isolado a TVC está relacionado ao melhor prognóstico. Os pacientes com pior evolução clínica têm a raça afro-brasileira, a alteração do nível de consciência, sexo masculino e idade acima de 32 anos como fatores determinantes de pior prognóstico em vinte e quatro meses. A identificação destes fatores é importante por direcionar um melhor tratamento na fase aguda da TVC para casos selecionados
Introduction: The cerebral venous thrombosis (CVT) clinical evolution is quite variable from complete recovery to death. Some European series and a multicenter study had identified prognostic factors related to CVT prognosis. The identification of these factors is important for the best therapeutic decision to patients. This study aims to identify the prognostic factors enrolled in clinical evolution of 111 patients with CVT in a prospective outcome clinical trial during two years. Subjects and Methods: One hundred and eleven patients were prospective followed with the diagnosis of CVT since acute phase diagnosis, confirmed by brain MRI and/or brain angiography (MRA , CTA or digital angiography). Information about clinical features and follow-up were filled on a clinical form. 96% of the patients were anticoagulated on heparin followed by warfarin treatment. The patients were investigated to predisposing factors to CVT. The clinical evaluation was accessed by the modified Rakin scale (mRs) after 3, 6, 12 and 24 months, considering patients with good outcome when mRs 2. The acute phase clinical features, laboratory and imaging data were compared as possible prognosis factors beyond univariate 2 test and the factors with statistical significance (p<0,1) and then analyzed by logistic regression adjusted and Odds Ratio values (confidence interval CI=95%). Results: The mean age of the patients was 35 years, 72% were women, and 40% were African Brazilian. The main clinical features observed were: headache 97%, focal sign 47%, epileptic seizure 40%, isolated ICH syndrome 40% and altered mental status 28%. All the patients were investigated to predisposing factors; 75% of the women were on oral contraceptive, 31% of the patients presented hereditary thrombophilia, 13 % antiphospholipid syndrome, 6% presented vasculitis, 25% other protrhrombotic state, 7% presented some local feature (arterialvenous malformation or infection) and 5% of women were pregnant or on puerperium. The neuroimaging data showed that 42% of the patients presented thrombosis in more than one venous system, 33% had hemorrhage infarcts, 18% ischemic venous infarcts and 20% of the patients had thrombosis of the deep venous system. After two years 17% had a mRs > 2 and the features enrolled on poor prognosis were: African Brazilian patients p=0,001; OR= 11,37 (95% IC 2.81- 46,08), altered mental status p=0,007; OR=4.56 (95% IC 1.61-19.45), male gender p=0,049 OR=3.55 (95% IC 1.00-12.55) and age over 32 years p=0,05 OR = 3.95 (95% IC 0,97- 15.20). The presence of oral contraceptives as isolated predisposing factor was related to good outcome CVT p=0,016; OR=5,17(95% IC 1.37-19.57) and after two years the mortality rate was 4,5%. Conclusion: This study data show that most patients with the diagnosis of CVT (83%) has a good outcome with the treatment, after two years follow up they have no symptoms or minimal deficits, and the presence of oral contraceptives as isolated predisposing factor was related to better outcome CVT. The patients with poor prognosis have the African Brazilian ethnic group, altered mental status, male gender and age over 32 years as the factors enrolled on bad clinical evolution in two years. The identification of these factors can have future value on treatment better choice on acute phase to selected CVT patients

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Piano, Luciana Pereira de Almeida de. "Valor do teste de dosagem do Dímero - D plasmático no diagnóstico do tromboembolismo venoso agudo." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-13022008-100326/.

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Introdução: A doença tromboembólica é um distúrbio complexo multicausal com sinais e sintomas inespecíficos, confundindo-se com outras enfermidades. Devido à sua gravidade buscam-se estratégias objetivando obter um diagnóstico precoce. O teste de dosagem do dímero - D plasmático parece ser uma alternativa para exclusão do diagnóstico de tromboembolismo venoso agudo. Objetivo: Avaliar o valor do teste de dosagem de dímero - D plasmático, utilizando o método Enzyme Linked Fluorescent Assay (ELFA), na rotina diagnóstica de tromboembolismo venoso agudo. Métodos: Em 89 pacientes com sinais e sintomas sugestivos de tromboembolismo pulmonar e/ou trombose venosa profunda foram realizadas dosagens do dímero - D pela técnica ELFA no equipamento VIDAS® - BioMérieux. Foram calculados os valores da sensibilidade, especificidade, valores preditivos positivo e negativo e acurácia do teste, bem como a curva ROC da amostra estudada. Todos os pacientes foram submetidos a exame por imagem para confirmação do evento tromboembólico agudo. Foi calculado o índice kappa para analisar o resultado do teste dímero - D versus resultados de exames por imagem. Resultados: Entre os 89 pacientes estudados (média de idade 54,3 anos; 51 mulheres), 36 (40,4%) apresentaram TEV e 53 não apresentaram trombose aguda (59,6%). Entre os pacientes sem trombose aguda 15 (28,3%) apresentaram resultado de dímero - D negativo. Todos pacientes com trombose apresentaram resultado de dímero - D positivo. O teste apresentou sensibilidade de 100%; especificidade de 28,3%; valor preditivo positivo de 48,6%; valor preditivo negativo de 100% e exatidão de 57,3%. A ASC para a amostra total estudada foi igual a 0,734, indicando que o teste é um bom preditor de trombose aguda. O valor do índice kappa para a amostra total foi igual a 0,24 (p<0,001), indicando uma concordância fraca entre dímero - D e diagnóstico confirmatório de trombose. Conclusão: A dosagem do dímero - D pelo método ELFA foi capaz de excluir o diagnóstico de tromboembolismo venoso agudo nessa amostra estudada. Os resultados obtidos nessa amostra estudada permitiram concluir que o uso do teste dímero - D em pacientes com suspeita de tromboembolismo venoso revelou alta sensibilidade no diagnóstico dessa enfermidade.
Introduction: The thromboembolic disease is a multicausal complex disturb with signals and symptoms that confusing itself with other diseases. Because its gravity strategies search objecting to get a faster diagnosis. The measure plasmatic D dimer test seems to be an alternative for exclusion of the diagnostic of acute venous thromboembolism. Objectives: To evaluate the value of the measure plasmatic D dimer test, using the method Enzyme Linked Fluorescent Assay (ELFA), in the diagnostic of acute venous thromboembolism. Methods: In 89 patients with signals and symptoms suggestive of pulmonary thromboembolism and/or deep vein thrombosis had been carried through measure D dimer by technique ELFA equipment VIDAS® - BioMérieux. The values of sensibility, accuracy specificity, predictive values positive and negative and of the test had been calculated, as well as curve ROC of the sample studied. All the patients had been submitted the image exams for the confirmation of the acute thromboembolism event. It was calculated kappa ratio to compare D dimer test results with image exams results. Results: Between 89 studied patients (mean of age 54.3 years; 51 women), 36 (40.4%) they had presented and 53 had not presented acute thrombosis (59.6%). It enters the patients without acute thromboembolism 15 (28.3%) had presented resulted negative of D dimer. All patients with thrombosis had presented resulted positive of D dimer. The test presented 100% sensibility; 28.3% of specificity; positive predictive value was 48.6%; 100% of negative predictive value and accuracy value was 57.3%. The area under the curve (AUC) to total sample studied was 0.734, it was showed that the test have a good prediction to acute thrombosis. The kappa ratio value was 0.24 (p<0.001) showing a bad concordat n to thrombosis diagnostic. Conclusion: The measure of D dimer by method ELFA was able to exclude the diagnostic of acute venous thromboembolism in this sample studied. The results obtained in this sample studied let to conclude that the D dimer test in patients with suspected of acute thromboembolism presented high sensibility to diagnostic of this disease.

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Dissertations / Theses on the topic 'Thrombose – Diagnostic'

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