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Journal articles on the topic 'Thygeson's Keratitis'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Nagra, Parveen K., Christopher J. Rapuano, Elisabeth J. Cohen, and Peter R. Laibson. "Thygeson's superficial punctate keratitis." Ophthalmology 111, no. 1 (2004): 34–37. http://dx.doi.org/10.1016/j.ophtha.2003.05.002.

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2

Gock, Germaine, Keith Ong, and Kathy McClellan. "A classical case of Thygeson's superficial punctate keratitis." Australian and New Zealand Journal of Ophthalmology 23, no. 1 (1995): 76–77. http://dx.doi.org/10.1111/j.1442-9071.1995.tb01652.x.

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3

Reinhard, T., and Rainer Sundmacher. "Topical cyclosporin A in Thygeson's superficial punctate keratitis." Graefe's Archive for Clinical and Experimental Ophthalmology 237, no. 2 (1999): 109–12. http://dx.doi.org/10.1007/s004170050204.

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4

Seo, Kyoung Yul, Jae Bum Lee, Roo Min Jun, and Eung Kweon Kim. "Recurrence of Thygeson's Superficial Punctate Keratitis After Photorefractive Keratectomy." Cornea 21, no. 7 (2002): 736–37. http://dx.doi.org/10.1097/00003226-200210000-00028.

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5

Fite, Steven W., and James Chodosh. "Recurrence of Thygeson's Superficial Punctate Keratitis After Photorefractive Keratectomy." Cornea 21, no. 7 (2002): 737. http://dx.doi.org/10.1097/00003226-200210000-00029.

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6

Cheng, Lulu L., Alvin L. Young, Angus KK Wong, Ricky WK Law, and Dennis SC Lam. "In vivo confocal microscopy of Thygeson's superficial punctate keratitis." Clinical & Experimental Ophthalmology 32, no. 3 (2004): 325–27. http://dx.doi.org/10.1111/j.1442-9071.2004.00783.x.

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7

Del Castillo, Jose M. Benitez, Javier Benitez Del Castillo, and Julian Garcia-Sanchez. "Effect of topical cyclosporin A on Thygeson's superficial punctate keratitis." Documenta Ophthalmologica 93, no. 3 (1997): 193–98. http://dx.doi.org/10.1007/bf02569059.

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8

Netto, Marcelo V., Maria Regina Chalita, and Ronald R. Krueger. "Thygeson's superficial punctate keratitis recurrence after laser in situ keratomileusis." American Journal of Ophthalmology 138, no. 3 (2004): 507–8. http://dx.doi.org/10.1016/j.ajo.2004.04.024.

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9

Fite, Steven W., and James Chodosh. "Photorefractive Keratectomy for Myopia in the Setting of Thygeson's Superficial Punctate Keratitis." Cornea 20, no. 4 (2001): 425–26. http://dx.doi.org/10.1097/00003226-200105000-00018.

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10

Connell, P. P., J. O'Reilly, S. Coughlan, L. M. T. Collum, and W. J. Power. "The role of common viral ocular pathogens in Thygeson's superficial punctate keratitis." British Journal of Ophthalmology 91, no. 8 (2007): 1038–41. http://dx.doi.org/10.1136/bjo.2006.104802.

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11

Marquezan, Maria Carolina, Heloisa Nascimento, Luis Antonio Vieira, et al. "Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis." American Journal of Ophthalmology 160, no. 4 (2015): 663–68. http://dx.doi.org/10.1016/j.ajo.2015.06.019.

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12

Steger, B., L. Speicher, E. Schmid, and W. Philipp. "Reversible presence of corpuscular mature dendritic cells in Thygeson's superficial punctate keratitis." Spektrum der Augenheilkunde 26, no. 1 (2012): 15–18. http://dx.doi.org/10.1007/s00717-012-0066-0.

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13

Azari, A. A. "Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis." Yearbook of Ophthalmology 2016 (2016): 135–37. https://doi.org/10.1016/j.yoph.2016.02.086.

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14

Steger, B., L. Speicher, and W. Philipp. "In-vivo confocal observation of giant dendritic cells in Thygeson's superficial punctate keratitis." Spektrum der Augenheilkunde 24, no. 6 (2010): 340–42. http://dx.doi.org/10.1007/s00717-010-0450-6.

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15

Maychuk, D. Y., A. O. Loshkareva, and I. A. Pronkin. "Features of clinical course and therapy of Thygeson's superficial punctate keratitis caused by cytomegalovirus lesion." Fyodorov journal of ophthalmic surgery, no. 3 (September 29, 2016): 48–52. http://dx.doi.org/10.25276/0235-4160-2016-3-48-52.

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16

Yang, Jong Yun, Woo Suk Chung, and Byoung Jin Ha. "A Case of Supratarsal Injection of Triamcinolone in Management of Chronic Thygeson's Superficial Punctate Keratitis." Journal of the Korean Ophthalmological Society 53, no. 5 (2012): 728. http://dx.doi.org/10.3341/jkos.2012.53.5.728.

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17

Reinhard, T., M. Roggendorf, I. Fengler, and R. Sundmacher. "PCR for varicella zoster virus genome negative in corneal epithelial cells of patients with Thygeson's superficial punctate keratitis." Eye 18, no. 3 (2004): 304–5. http://dx.doi.org/10.1038/sj.eye.6700621.

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18

Tabery, H. M. "Corneal Surface Changes in Thygeson's Superficial Punctate Keratitis: A Clinical and Noncontact Photomicrographic in Vivo Study in the Human Cornea." European Journal of Ophthalmology 14, no. 2 (2004): 85–93. http://dx.doi.org/10.1177/112067210401400201.

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19

Chan, Tommy C. Y., Hatty H. T. Chau, Amar Krishna Bhat, Ken K. Nischal, and Vishal Jhanji. "Thygeson’s superficial punctate keratitis." Journal of EuCornea 3, no. 3-5 (2019): 5–8. http://dx.doi.org/10.1016/j.xjec.2019.11.001.

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20

Adnan Ahmad, Shams Ul Haq, Jamal Hussain, Javed Rasool, and Mubashir Rehman. "Efficacy and safety of topical tacrolimus 0.03% ointment in thygeson superficial punctate keratitis." Professional Medical Journal 30, no. 01 (2023): 92–95. http://dx.doi.org/10.29309/tpmj/2023.30.01.7193.

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Objective: To assess the effectiveness of topical tacrolimus (TCL) 0.03% dermatological ointment in the treatment of patients with Thygeson superficial punctate keratitis. Study Design: Retrospective Review. Setting: Eye OPD of Qazi Hussain Ahmad Medical Complex, Nowshera. Period: Jan 2019 to Jan 2021. Material & Methods: Twelve patients with Thygeson superficial punctate keratitis (TSPK) were included retrospectively by reviewing their medical records. Eight patients were unresponsive to topical steroids and/or lubricants. Diagnosis was made based on the history and clinical findings. All

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21

Tanzer, David J., and Ronald E. Smith. "Superficial Punctate Keratitis of Thygeson." Cornea 18, no. 6 (1999): 729. http://dx.doi.org/10.1097/00003226-199911000-00017.

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22

Prabhakar, S. K. "Thygeson’s Superficial Punctate Keratitis- Case Report and Review." IOSR Journal of Dental and Medical Sciences 11, no. 5 (2013): 07–09. http://dx.doi.org/10.9790/0853-1150709.

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23

Gagrani, Meghal, Elizabeth A. Conner, Jamila Hiasat, et al. "Management of Thygeson’s superficial punctate keratitis in children." Journal of American Association for Pediatric Ophthalmology and Strabismus 26, no. 4 (2022): e43. http://dx.doi.org/10.1016/j.jaapos.2022.08.161.

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24

Duszak, Robert S. "Diagnosis and management of Thygeson’s superficial punctate keratitis." Optometry - Journal of the American Optometric Association 78, no. 7 (2007): 333–38. http://dx.doi.org/10.1016/j.optm.2006.12.014.

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25

Fintelmann, Robert E., David W. Vastine, Michele M. Bloomer, and Todd P. Margolis. "Thygeson Superficial Punctate Keratitis and Scarring." Cornea 31, no. 12 (2012): 1446–48. http://dx.doi.org/10.1097/ico.0b013e31823f777f.

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26

Bovkunenko, R. F. "Clinical cases of lesions of the cornea by the disease Thygeson." Modern technologies in ophtalmology, no. 2 (May 29, 2023): 365–68. http://dx.doi.org/10.25276/2312-4911-2023-2-365-368.

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In 1950, Thygeson P. first described a series of cases of superficial point keratitis, which is a chronic, recurrent disease and is characterized by small, oval sub-and intraepithelial whitish-gray corneal opacities. The disease is usually bilateral, but can be asymmetric. Opacities tend to be centrally located, which causes a decrease in visual acuity. The disease affects both sexes, but a higher incidence was found in women. Despite multiple studies, the etiology of the disease has not been determined. An autoimmune mechanism of the disease has been suggested. Keywords: Tigason's disease, Ti

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27

Zonnevylle, K., D. Thoma, E. Mulliez, S. Ghekiere, J. Blanckaert, and M. D. A. Blanckaert. "Thygeson’s superficial punctate keratitis: Case report and literature review." Journal of EuCornea 3, no. 3-5 (2019): 9–12. http://dx.doi.org/10.1016/j.xjec.2019.12.003.

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28

Shoughy, Samir S., and Khalid F. Tabbara. "Topical Tacrolimus in Thygeson Superficial Punctate Keratitis." Cornea 39, no. 6 (2020): 742–44. http://dx.doi.org/10.1097/ico.0000000000002224.

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29

Choe, Woo Seok, and Tae Gi Kim. "Bilateral Thygeson’s Superficial Punctate Keratitis with Dendritic Corneal Lesion: A Case Report." Medicina 59, no. 1 (2023): 163. http://dx.doi.org/10.3390/medicina59010163.

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Thygeson’s superficial punctate keratitis (TSPK) is a recurrent bilateral corneal epithelial disease. Typically, small, multiple discrete epithelial lesions occur in the central cornea. However, dendritic corneal lesions are rare. Herein, we report a rare case of TSPK in both eyes after a unilateral dendritic corneal lesion. A 42-year-old woman presented with decreased vision and foreign body sensation in her right eye that persisted for 1 month. Her uncorrected visual acuity and best-corrected visual acuity (BCVA) were 20/160 in the right eye. Slit-lamp microscopy revealed a dendritic lesion

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30

Jin, Li, Qiao Junbo, Cai Meng, and Wang Liya. "Laser confocal microscopy findings of Thygeson superficial punctate keratitis." Chinese Medical Journal 127, no. 3 (2014): 597–98. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20132737.

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31

Kobayashi, Akira, Hideaki Yokogawa, and Kazuhisa Sugiyama. "In Vivo Laser Confocal Microscopy Findings of Thygeson Superficial Punctate Keratitis." Cornea 30, no. 6 (2011): 675–80. http://dx.doi.org/10.1097/ico.0b013e318200099d.

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32

Reinhard, Thomas, and Rainer Sundmacher. "Lokale Ciclosporin A Therapie bei Keratitis superficialis punctata Thygeson - eine Pilotstudie*." Klinische Monatsblätter für Augenheilkunde 209, no. 10 (1996): 224–27. http://dx.doi.org/10.1055/s-2008-1035307.

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33

Kobayashi, Akira, Shigeyuki Ijiri, Taeko Ohta, and Kazuhisa Sugiyama. "Disappearance of Honeycomb Opacity of Thiel-Behnke Corneal Dystrophy After Thygeson Superficial Punctate Keratitis." Cornea 24, no. 8 (2005): 1029–30. http://dx.doi.org/10.1097/01.ico.0000160974.81200.40.

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34

U, Agraval, Edington M, and Ramaesh K. "Steroid Sparing Symptomatic Control of Thygeson's Superficial Punctate Keratitis (TSPK)." October 7, 2016. https://doi.org/10.19070/2332-290X-1600052.

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Introduction: Thygeson’s superficial punctate keratitis (TSPK) is a chronic, recurrent disorder affecting the anterior surface of the cornea. Common symptoms include photophobia, epiphora, pain and blurred vision. The management of TSPK is challenging, and long-term combined therapy is often required, namely steroids. We present a case of TSPK that was managed with a novel regenerative agent (RGTA) resulting in the symptomatic control of the condition. Methods: Observational case report. Case: A 25-year-old male patient with bilateral TSPK presented with ongoing symptoms of irritation, photoph

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35

Hasanreisoglu, Murat, and Rahamim Avisar. "Long-term topical cyclosporin A therapy in Thygeson's superficial punctate keratitis: a case report." Cases Journal 1, no. 1 (2008). http://dx.doi.org/10.1186/1757-1626-1-415.

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36

Saad, Rana, Sami Saad, Oscar Haigh, Domitille Molinari, Marc Labetoulle, and Antoine Rousseau. "Using pre-existing social networks to determine the burden of disease and real-life needs in rare diseases: the example of Thygeson's superficial punctate keratitis." Orphanet Journal of Rare Diseases 16, no. 1 (2021). http://dx.doi.org/10.1186/s13023-021-01707-6.

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Abstract Background Thygeson’s superficial punctate keratitis (TSPK) is a rare and still poorly understood disease of the ocular surface, responsible for recurrent episodes of photophobia and eye pain. While TSPK is considered as a benign condition, a subset of patients has frequent recurrences or even chronic disease, two situations in which there are currently no therapeutic guidelines. We used a preexisting Facebook TSPK patient support group to assess the clinical journey and the burden of disease of TSPK. Results An online survey was sent to the patient support group. The first part of th

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37

Mandal, Niraj, Sonia N. Yeung, Carol Tadrous, and Alfonso Iovieno. "Thygeson’s superficial punctate keratitis." Graefe's Archive for Clinical and Experimental Ophthalmology, March 12, 2022. http://dx.doi.org/10.1007/s00417-022-05617-6.

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38

Gagrani, Meghal, Elizabeth A. Conner, Hannah Scanga, et al. "Thygeson’s superficial punctate keratitis in children." Eye, April 21, 2023. http://dx.doi.org/10.1038/s41433-023-02533-9.

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39

U, Agraval, Edington M, and Ramaesh K. "Steroid Sparing Symptomatic Control of Thygeson’s Superficial Punctate Keratitis (TSPK)." International Journal of Ophthalmology & Eye Science, October 7, 2016, 249–52. http://dx.doi.org/10.19070/2332-290x-1600052.

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40

Nesemann, John M., Thuy Doan, and Gerami D. Seitzman. "Epstein-Barr Virus Associated with Unilateral Thygeson’s Superficial Punctate Keratitis." Ophthalmology, May 2025. https://doi.org/10.1016/j.ophtha.2025.04.029.

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41

Tang, Xiao-Jiao, Qing Liu, Lian-Hong Pi, Xin-Ke Chen, and Lin Chen. "Thygeson’s superficial punctate keratitis (TSPK): a paediatric case report and review of the literature." BMC Ophthalmology 21, no. 1 (2021). http://dx.doi.org/10.1186/s12886-020-01790-6.

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Abstract Background Thygeson’s superficial punctate keratitis (TSPK) is reportedly a rare disease with an insidious onset, numerous remissions and exacerbations, and a long duration. The corneal lesions are elevated, whitish–grey in colour, and granular in the intraepithelium. A few reported cases of TSPK exist, and paediatric experience is limited. Due to the unknown aetiology and controversial treatment strategies for TSPK, we performed a literature review to summarize the criteria for the diagnosis, treatment and prognosis of TSPK to provide a basis for the treatment of TSPK in paediatric p

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42

Moshirfar, Majid, Telyn Peterson, Emilie Ungricht, et al. "Thygeson Superficial Punctate Keratitis: A Clinical and Immunologic Review." Eye & Contact Lens: Science & Clinical Practice Publish Ahead of Print (March 15, 2022). http://dx.doi.org/10.1097/icl.0000000000000891.

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43

Tagmouti, Adam, Hamza Lazaar, Meryem Benchekroun, et al. "Association Between Thygeson Superficial Punctate Keratitis and Celiac Disease." Cureus, March 8, 2025. https://doi.org/10.7759/cureus.80252.

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44

Hutchinson, Kelly Ann, Daniel Peretz, Mahshad Darvish, Julia Talajic, and Johanna Choremis. "Rare Case of Thygeson Superficial Punctate Keratitis After COVID-19 Vaccination." Cornea, June 27, 2023. http://dx.doi.org/10.1097/ico.0000000000003333.

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Purpose: The aim of this study was to elucidate a rare corneal association of the coronavirus disease 2019 (COVID-19) vaccine. Although cases of corneal involvement after vaccination have been reported, we present the first case of Thygeson superficial punctate keratitis (TSPK) linked to the COVID-19 vaccine. Methods: This study is a case report. Results: A 25-year-old woman was assessed in the ophthalmology clinic for recurrent ocular surface symptoms after receiving the COVID-19 vaccine. She was followed in clinic and was found to have a remitting and recurring pattern of bilateral intraepit

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