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Journal articles on the topic 'Thymol derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Blažíčková, Michaela, Jaroslav Blaško, Róbert Kubinec, and Katarína Kozics. "Newly Synthesized Thymol Derivative and Its Effect on Colorectal Cancer Cells." Molecules 27, no. 9 (2022): 2622. http://dx.doi.org/10.3390/molecules27092622.

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Thymol affects various types of tumor cell lines, including colorectal cancer cells. However, the hydrophobic properties of thymol prevent its wider use. Therefore, new derivatives (acetic acid thymol ester, thymol β-D-glucoside) have been synthesized with respect to hydrophilic properties. The cytotoxic effect of the new derivatives on the colorectal cancer cell lines HT-29 and HCT-116 was assessed via MTT assay. The genotoxic effect was determined by comet assay and micronucleus analysis. ROS production was evaluated using ROS-Glo™ H2O2 Assay. We confirmed that one of the thymol derivatives

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2

Dantas, Jaciele O., Sócrates C. H. Cavalcanti, Ana Paula A. Araújo, et al. "Formicidal Potential of Thymol Derivatives: Adverse Effects on the Survival and Behavior of Acromyrmex balzani." Agriculture 13, no. 7 (2023): 1410. http://dx.doi.org/10.3390/agriculture13071410.

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Leaf-cutting ants are important pests of agricultural and forest crops. Currently, few insecticides are registered for the control of these insects. Natural bioactive molecules can serve as models for the synthesis of new insecticidal compounds. Such ant killer products must be sustainable and efficient, considering not only lethal effects, but also sublethal effects, which can interfere with behavior and communication between colony members. In this study, we analyzed the toxicity of the monoterpene thymol and its derivatives, as well as the sublethal effects of these compounds on the behavio

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3

Tori, Motoo, Yukiko Ohara, Katsuyuki Nakashima, and Masakazu Sono. "Thymol Derivatives fromEupatoriumfortunei." Journal of Natural Products 64, no. 8 (2001): 1048–51. http://dx.doi.org/10.1021/np0101191.

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4

Kumar, Ajai, Suriya P. Singh, and Sudarshan S. Chhokar. "Thymol and its Derivatives as Antimicrobial Agents." Natural Product Communications 3, no. 5 (2008): 1934578X0800300. http://dx.doi.org/10.1177/1934578x0800300528.

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From the seeds of C arum copticum thymol (1) was isolated as the major component and ten derivatives (2–11) were prepared by reacting it with different acid chlorides in a single step. They were evaluated for antimicrobial activity against twelve bacterial strains and nine fungal strains using disc diffusion and broth dilution assays. Derivative 9 was found to be most active against both bacterial and fungal strains.

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5

Zee, Ok Pyo, Dae Keun Kim, and Kang Ro Lee. "Thymol derivatives fromCarpesium divaricatum." Archives of Pharmacal Research 21, no. 5 (1998): 618–20. http://dx.doi.org/10.1007/bf02975385.

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6

Yan, Tay Karh, Asnuzilawati Asari, Siti Aishah Salleh, and Wahizatul Afzan Azmi. "Eugenol and Thymol Derivatives as Antifeedant Agents against Red Palm Weevil, Rhynchophorus ferrugineus (Coleoptera: Dryophthoridae) Larvae." Insects 12, no. 6 (2021): 551. http://dx.doi.org/10.3390/insects12060551.

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Coconut palms in Malaysia are infested by a destructive invasive pest, RPW since 2007, and the pest’s population is difficult to control. At present, RPW control management mainly relies on the use of monocrotophos, which is administered by the trunk injection method. However, this pesticide can negatively impact human health and the ecosystem. Plant EO that can be used as a bio-pesticide is highly recommended as an alternative to monocrotophos because of its target-specific and eco-friendly properties. The antifeedant activity of eight eugenol and thymol derivatives from clove and thyme EOs w

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7

Sokhraneva, V. A., D. A. Yusupova, V. S. Boriskin, and N. V. Groza. "Obtaining substituted phenol derivatives with potential antimicrobial activity." Fine Chemical Technologies 17, no. 3 (2022): 210–30. http://dx.doi.org/10.32362/2410-6593-2022-17-3-210-230.

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Objectives. With the growing resistance of pathogenic microorganisms to antibiotics, the development of new antimicrobial drugs offering specific mechanisms of action becomes an urgent task. Only few antimicrobials offer a broad spectrum of activity against gram-positive and gram-negative bacteria, molds, and yeasts. In this regard, the purpose of the work was to develop methods for synthesizing biologically active derivatives of alkyl-substituted phenols (reactions at the hydroxy group) to study their biological effect.Methods. The synthesis of imidazole acetates of substituted phenols was ca

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8

Phan, Minh Giang, Vu Minh Trang, Do Thi Viet Huong, Susumu Kawakami, and Hideaki Otsuka. "Thymol Derivatives from Eupatorium fortunei." Records of Natural Products 13, no. 5 (2019): 434–39. http://dx.doi.org/10.25135/rnp.122.18.11.1032.

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9

Brookes, Bridget, H. Candy, and Karl Pegel. "Two Thymol Derivatives fromCallilepis laureola." Planta Medica 51, no. 01 (1985): 32–34. http://dx.doi.org/10.1055/s-2007-969385.

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10

González, Antonio G., Jaime Bermejo Barrera, F. Estevez Rosas, Angel C. Yanes Hernández, J. Espiñeira, and P. Joseph-Nathan. "Thymol derivatives from schizogyne glaberrima." Phytochemistry 25, no. 12 (1986): 2889–91. http://dx.doi.org/10.1016/s0031-9422(00)83761-9.

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11

Mariano, Martínez V., Sanchez F. Antonio, and Pedro Joseph-Nathan. "Thymol derivatives from Calea nelsonii." Phytochemistry 26, no. 9 (1987): 2577–79. http://dx.doi.org/10.1016/s0031-9422(00)83881-9.

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12

González, Antonio G., Jaime Bermejo Barrera, Jorge Triana Méndez, José Luis Eiroa Martínez, and Mariana López Sánchez. "Thymol derivatives from Vieraea laevigata." Phytochemistry 32, no. 1 (1992): 202–3. http://dx.doi.org/10.1016/0031-9422(92)80133-y.

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13

Bustos-Brito, Celia, Baldomero Esquivel, Fernando Calzada, et al. "Further Thymol Derivatives fromAgeratina cylindrica." Chemistry & Biodiversity 13, no. 10 (2016): 1281–89. http://dx.doi.org/10.1002/cbdv.201600038.

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14

Robledo, Sara, Edison Osorio, Diana Muñoz, et al. "In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives." Antimicrobial Agents and Chemotherapy 49, no. 4 (2005): 1652–55. http://dx.doi.org/10.1128/aac.49.4.1652-1655.2005.

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ABSTRACT The in vitro and in vivo antileishmanial and cytotoxic activities of thymol and structural derivatives in comparison to those of Glucantime were studied. The results showed here suggest that thymol and hemisynthetic derivatives have promising antileishmanial potential and could be considered as new lead structures in the search for novel antileishmanial drugs.

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15

Omrani, Amani, Meriam Ben Youssef, Ines Sifaoui, et al. "Mechanism Insight of Cell Death Signaling by Thymol Derivatives on Trypanosomatidae Protozoan Parasites." Antibiotics 14, no. 4 (2025): 383. https://doi.org/10.3390/antibiotics14040383.

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Leishmaniasis and Chagas disease are parasitic diseases considered to be among the most important neglected diseases, with implications for both developed and developing countries. Currently, there are no effective therapeutic treatments for these diseases due to challenges in drug administration, high toxicity, high costs, and drug resistance. In this study, a series of eleven thymol derivatives were designed, synthesized, and evaluated for their in vitro kinetoplastid activity against Leishmania amazonensis and Trypanosoma cruzi, as well as their cytotoxicity against a murine macrophage cell

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16

Danova, Ade, Elvira Hermawati, Warinthorn Chavasiri, Didin Mujahidin, Anita Alni, and Robby Roswanda. "Discovery of thymol-fused chalcones as new competitive \(\alpha\)-glucosidase inhibitors: Design, synthesis, biological evaluation, and molecular modeling studies." Communications in Science and Technology 9, no. 2 (2024): 322–30. https://doi.org/10.21924/cst.9.2.2024.1497.

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This study aims to synthesize and evaluate the inhibitory activity of thymol derivatives targeting ?-glucosidase using in vitro and in silico studies. Ten thymol derivatives (2-11) including five new thymol-fused chalcones (7-11) were successfully synthesized. Among them, four compounds (4, 8, 9, 11) showed the best inhibitory activity with IC50 values of 18.45, 13.75, 8.86, and 10.67µM compared with acarbose (IC50 = 832.82 µM), respectively. The kinetic study of three new thymol-fused chalcones (8, 9, 11) exhibited a competitive inhibition. Molecular docking demonstrated the predicted interac

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17

Stojakowska, Anna, Janusz Malarz, and Wanda Kisiel. "Thymol Derivatives from a Root Culture of Inula helenium." Zeitschrift für Naturforschung C 59, no. 7-8 (2004): 606–8. http://dx.doi.org/10.1515/znc-2004-7-827.

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AbstractA root culture of Inula helenium L. was established from leaf explants of aseptic seedlings. An ethanol extract from the lyophilised roots was fractionated using different chromatographic techniques (CC, TLC). The main secondary metabolites found in the root culture were two thymol derivatives: 10-isobutyryloxy-8,9- epoxy-thymol isobutyrate (1) and 10-isobutyryloxy-6- methoxy-8,9-epoxy-thymol isobutyrate (2). The compounds were identified by spectral methods. Quantification of compound 1 in plant material was done by analytical RP-HPLC.

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18

Ahmed, A. "Farnesol and Thymol Derivatives fromAsteriscus pygmaeus." Planta Medica 57, S 2 (1991): A78—A79. http://dx.doi.org/10.1055/s-2006-960348.

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19

Marco, J. Alberto, Juan F. Sanz-Cervera, and Enrique Manglano. "Chlorinated thymol derivatives from Inula crithmoides." Phytochemistry 33, no. 4 (1993): 875–78. http://dx.doi.org/10.1016/0031-9422(93)85294-2.

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20

Rebelo, Monaliza M., Eloisa Helena A. Andrade, José Augusto M. Corrêa, and José Guilherme S. Maia. "Phenolic Monoterpenes Conversion of Conobea scoparioides Essential Oil by Hydrotalcite Synthesized from Blast-Furnace Slag." Plants 13, no. 9 (2024): 1199. http://dx.doi.org/10.3390/plants13091199.

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Conobea scoparioides (Plantaginaceae) is an herbaceous plant known as “pataqueira” that grows wild in seasonally wet areas of the Amazon region. It is used for aromatic baths and anti-protozoan remedies by the Brazilian Amazon native people. The main volatile compounds identified in the essential oil of “Pataqueira” were the phenolic monoterpenes thymol and thymol methyl ether and their precursors, the monoterpene hydrocarbons α-phellandrene and p-cymene. A hydrotalcite synthesized from blast-furnace slag exhibited a 3:2 (Mg/Al) molar ratio, and this layered double hydroxide (LDH) was evaluate

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21

Piombino, Claudio, Heiko Lange, Federica Sabuzi, Pierluca Galloni, Valeria Conte, and Claudia Crestini. "Lignosulfonate Microcapsules for Delivery and Controlled Release of Thymol and Derivatives." Molecules 25, no. 4 (2020): 866. http://dx.doi.org/10.3390/molecules25040866.

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Thymol and the corresponding brominated derivatives constitute important biological active molecules as antibacterial, antioxidant, antifungal, and antiparasitic agents. However, their application is often limited, because their pronounced fragrance, their poor solubility in water, and their high volatility. The encapsulation of different thymol derivatives into biocompatible lignin-microcapsules is presented as a synergy-delivering remedy. The adoption of lignosulfonate as an encapsulating material possessing relevant antioxidant activity, as well as general biocompatibility allows for the de

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22

Alamri, Mohammed A., Maged S. Abdel-Kader, Mohamad Ayman Salkini, and Mubarak A. Alamri. "Thymol and carvacrol derivatives as anticancer agents; synthesis, in vitro activity, and computational analysis of biological targets." RSC Advances 14, no. 42 (2024): 30662–72. http://dx.doi.org/10.1039/d4ra03941f.

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23

Getrey, Laura, Thomas Krieg, Frank Hollmann, Jens Schrader, and Dirk Holtmann. "Enzymatic halogenation of the phenolic monoterpenes thymol and carvacrol with chloroperoxidase." Green Chem. 16, no. 3 (2014): 1104–8. http://dx.doi.org/10.1039/c3gc42269k.

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24

Liang, Hengxing, Fukai Bao, Xiaoping Dong, et al. "Antibacterial Thymol Derivatives Isolated from Centipeda minima." Molecules 12, no. 8 (2007): 1606–13. http://dx.doi.org/10.3390/12081606.

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25

Trang, Nguyen thi, Martin Wanner, Gerrit-Jan Koomen, and Nguyen Dung. "New Acetophenone and Thymol Derivatives fromEupatorium stoechadosmum." Planta Medica 59, no. 05 (1993): 480–81. http://dx.doi.org/10.1055/s-2006-959741.

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26

Rahim, Nurul Hazwani Che Abdul, Asnuzilawati Asari, Noraznawati Ismail, Fauziah Abdullah, Hasnah Osman, and Soraya Shafawati Mohamad Tahier. "Synthesis and Antibacterial Study of Thymol Derivatives." Asian Journal of Chemistry 30, no. 1 (2017): 126–28. http://dx.doi.org/10.14233/ajchem.2018.20933.

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27

Ahmed, Ahmed A. "Farnesol and Thymol Derivatives from Asteriscus, pygmaeus." Journal of Natural Products 55, no. 6 (1992): 824–27. http://dx.doi.org/10.1021/np50084a022.

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28

Radulović, Niko S., Miljana R. Đorđević, and Polina D. Blagojević. "Structural revision of aristol: a fresh look at the oxidative coupling of thymol under iodination conditions." RSC Advances 6, no. 73 (2016): 69067–82. http://dx.doi.org/10.1039/c6ra11296j.

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29

González, Antonio G., Carlos Yanes Hernández, and Jaime Bermejo Barrera. "Thymol derivatives and a chromene from Ageratina glechonophylla." Phytochemistry 31, no. 2 (1992): 714–16. http://dx.doi.org/10.1016/0031-9422(92)90072-x.

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30

de Morais, Selene Maia, Nadja Soares Vila-Nova, Claudia Maria Leal Bevilaqua, et al. "Thymol and eugenol derivatives as potential antileishmanial agents." Bioorganic & Medicinal Chemistry 22, no. 21 (2014): 6250–55. http://dx.doi.org/10.1016/j.bmc.2014.08.020.

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31

Weremczuk-Jeżyna, I., W. Kisiel, and H. Wysokińska. "Thymol derivatives from hairy roots of Arnica montana." Plant Cell Reports 25, no. 9 (2006): 993–96. http://dx.doi.org/10.1007/s00299-006-0157-y.

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32

Paolini, Julien, Alain Muselli, Antoine-François Bernardini, Ange Bighelli, Joseph Casanova, and Jean Costa. "Thymol derivatives from essential oil ofDoronicum corsicum L." Flavour and Fragrance Journal 22, no. 6 (2007): 479–87. http://dx.doi.org/10.1002/ffj.1824.

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33

Moszner, Norbert, Ulrich Salz, and Volker Rheinberger. "Synthesis and polymerization of unsaturated derivatives of thymol." Polymer Bulletin 33, no. 1 (1994): 7–12. http://dx.doi.org/10.1007/bf00313467.

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34

Stojakowska, Anna, Janusz Malarz, and Wanda Kisiel. "Terpenoids from a multiple shoot culture of Telekia speciosa." Acta Societatis Botanicorum Poloniae 80, no. 3 (2011): 253–56. http://dx.doi.org/10.5586/asbp.2011.019.

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Multiple shoots of <em>Telekia speciosa </em>were cultivated on MS medium containing 4.44 µM BAP and 0.54 µM NAA, solidified with agar. After eight weeks of culture the shoots were harvested and extracted with methanol. From the methanol extract one pseudoguaianolide – 2,3-dihydroaromaticin and three thymol derivatives: 8-hydroxy-9,10-diisobutyryloxythymol, 10-isobutyryloxy-8,9-epoxythymyl isobutyrate and 10-(2-methylbutyryloxy)-8,9-epoxythymyl isobutyrate were isolated as major secondary metabolites. Moreover, the shoots produced megastigmane and monoterpene glucosides, which were

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35

Zhang, Mei, Jin-Kui Ouyang, Qiao-Lin Xu, et al. "Thymol derivatives with antibacterial and cytotoxic activity from the aerial parts of Ageratina adenophora." RSC Advances 11, no. 10 (2021): 5755–61. http://dx.doi.org/10.1039/d0ra08885d.

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Eight thymol derivatives including three new ones (1–3) were obtained from the aerial parts of Ageratina adenophora, with most of them, in particular 1 and 5, showing notable in vitro antimicrobial and cytotoxic activity.

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36

Biernasiuk, Anna, Anna Berecka-Rycerz, Anna Gumieniczek, et al. "The newly synthesized thiazole derivatives as potential antifungal compounds against Candida albicans." Applied Microbiology and Biotechnology 105, no. 16-17 (2021): 6355–67. http://dx.doi.org/10.1007/s00253-021-11477-7.

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Abstract Recently, the occurrence of candidiasis has increased dramatically, especially in immunocompromised patients. Additionally, their treatment is often ineffective due to the resistance of yeasts to antimycotics. Therefore, there is a need to search for new antifungals. A series of nine newly synthesized thiazole derivatives containing the cyclopropane system, showing promising activity against Candida spp., has been further investigated. We decided to verify their antifungal activity towards clinical Candida albicans isolated from the oral cavity of patients with hematological malignanc

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37

Natal, Carolina M., Maria José G. Fernandes, Nuno F. S. Pinto, et al. "New carvacrol and thymol derivatives as potential insecticides: synthesis, biological activity, computational studies and nanoencapsulation." RSC Advances 11, no. 54 (2021): 34024–35. http://dx.doi.org/10.1039/d1ra05616f.

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Thymol and carvacrol derivatives were synthesised. Two of them proved to be mildly active against Sf9 insect cell line and one has presented selectivity by proving to be less toxic to human cells than the naturally derived starting materials.

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38

Austgulen, Liv-Torill, Einar Solheim, and Ronald R. Scheline. "Metabolism in Rats ofp-Cymene Derivatives: Carvacrol and Thymol." Pharmacology & Toxicology 61, no. 2 (1987): 98–102. http://dx.doi.org/10.1111/j.1600-0773.1987.tb01783.x.

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39

Schüngel, Juliane, and Claus M. Passreiter. "New Diacylated 2-Hydroxythymol Derivatives from Melampodium divaricatum." Zeitschrift für Naturforschung C 57, no. 11-12 (2002): 966–68. http://dx.doi.org/10.1515/znc-2002-11-1201.

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Melampodium divaricatum is a medicinal plant, which occurs in Central America. In a recent paper we reported the occurrence of acylated 2-hydroxy thymol glycosides as main constituents in this plant. This paper deals with the isolation of two new 2,5-dihydroxythymol ester derivatives. The formerly reported sesquiterpene lactone mikanokryptin was not found in our plant material.

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40

K., P. RODA, N. VANSDADIA R., and PAREKH HANSA. "Studies on 4-Thiazolidinones. Part-I. Preparation of 2-Aryl-3-[2'-isopropyl-5'-methylphenoxyacetylamino]-5H /methyl-4-thiazolidinones." Journal of Indian Chemical Society Vol. 63, June 1986 (1986): 594–95. https://doi.org/10.5281/zenodo.6271365.

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Department of Chemistry, Saurashtra University, Rajkot-360 005 Manuscript <em>received 16 August 2985, revised 8 January 1986, accepted 8 May 1986</em> Some new 4-thiazolidinones have been prepared having 2-isopropyl-5-methylphenoxyacetylamino moiety. The Schiff base from 2-isopropyl-5-methylphenoxy-acetylhydrazide were condensed with thioglycolic and thiolactic acid. The constitution was supported by it spectra.

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41

Szostek, Tomasz, Daniel Szulczyk, Jolanta Szymańska-Majchrzak, et al. "Design and Synthesis of Menthol and Thymol Derived Ciprofloxacin: Influence of Structural Modifications on the Antibacterial Activity and Anticancer Properties." International Journal of Molecular Sciences 23, no. 12 (2022): 6600. http://dx.doi.org/10.3390/ijms23126600.

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Sixteen new Ciprofloxacin derivatives were designed and successfully synthesized. In an in silico experiment, lipophilicity was established for obtained compounds. All compounds were screened for antimicrobial activity using standard and clinical strains. As for Gram-positive hospital microorganisms, all tested derivatives were active. Measured MICs were in the range 1–16 µg/mL, confirming high antimicrobial potency. Derivative 12 demonstrated activity against all standard Gram-positive Staphylococci, within the range of 0.8–1.6 µg/mL and was confirmed as the leading structure with MICs 1 µg/m

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42

Szilvássy, Blanka, Gábor Rak, Szilvia Sárosi, Ildikó Novák, Zsuzsanna Pluhár, and László Abrankó. "Polyphenols in the Aqueous Extracts of Garden Thyme (Thymus vulgaris) Chemotypes Cultivated in Hungary." Natural Product Communications 8, no. 5 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800516.

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Thyme is used worldwide both as a spice and crude drug. In addition, nowadays in the food industry it has increasing significance as a natural antioxidant. Volatile aromatic compounds of thyme have been thoroughly characterized; however, the non-volatile compounds may also contribute to the organoleptic quality and antioxidant properties. The aim of this work is to determine the phenolic acids and to profile the flavonoid compounds in the aqueous extract of two chemotypes of Thymus vulgaris L. Experiments were carried out using high performance liquid chromatography-electrospray ionization-tan

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43

Schorr, Renan R., Meira J. Ballesteros Garcia, Debora Petermann, et al. "Eugenol, Isoeugenol, Thymol, Carvacrol, and Ester Derivatives as an Ecofriendly Option to Control Glomerella Leaf Spot and Bitter Rot on Apple." Plants 13, no. 22 (2024): 3196. http://dx.doi.org/10.3390/plants13223196.

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Glomerella leaf spot (GLS) and bitter rot (BR) are severe diseases of apple. Colletotrichum nymphaeae and Colletotrichum chrysophillum are the main species in Brazil. To control GLS and BR in Brazilian apple orchards, mancozeb and thiophanate-methyl fungicides are still used despite reported Colletotrichum resistance to these active ingredients. In addition, mancozeb has been banned from apple-importing countries and it has been a great challenge for apple producers to find products for its replacement that are eco-friendly. So, this study aimed to search for alternatives to control the diseas

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44

Dong, Li-Mei, Mei Zhang, Qiao-Lin Xu, et al. "Two New Thymol Derivatives from the Roots of Ageratina adenophora." Molecules 22, no. 4 (2017): 592. http://dx.doi.org/10.3390/molecules22040592.

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45

Addo, Justice Kwaku, Ernest Owusu-Ansah, Nicholas T. K. D. Dayie, Xavier Cheseto, and Baldwyn Torto. "Synthesis of 1,2,3-triazole-thymol derivatives as potential antimicrobial agents." Heliyon 8, no. 10 (2022): e10836. http://dx.doi.org/10.1016/j.heliyon.2022.e10836.

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46

Chen, Jih-Jung, Yun-Chen Tsai, Tsong-Long Hwang, and Tai-Chi Wang. "Thymol, Benzofuranoid, and Phenylpropanoid Derivatives: Anti-inflammatory Constituents fromEupatorium cannabinum." Journal of Natural Products 74, no. 5 (2011): 1021–27. http://dx.doi.org/10.1021/np100923z.

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47

Talavera-Alemán, Armando, Gabriela Rodríguez-García, Yliana López, et al. "Systematic evaluation of thymol derivatives possessing stereogenic or prostereogenic centers." Phytochemistry Reviews 15, no. 2 (2015): 251–77. http://dx.doi.org/10.1007/s11101-015-9412-6.

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48

Kaur, Ranjeet, Mahendra P. Darokar, Sunil Kumar Chattopadhyay, Vinay Krishna, and Ateeque Ahmad. "Synthesis of halogenated derivatives of thymol and their antimicrobial activities." Medicinal Chemistry Research 23, no. 5 (2013): 2212–17. http://dx.doi.org/10.1007/s00044-013-0809-8.

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49

Bouhtit, Fatima, Mehdi Najar, Douâa Moussa Agha, et al. "New Anti-Leukemic Effect of Carvacrol and Thymol Combination through Synergistic Induction of Different Cell Death Pathways." Molecules 26, no. 2 (2021): 410. http://dx.doi.org/10.3390/molecules26020410.

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Acute myeloid leukemia (AML) is a cancer of the myeloid lineage of blood cells, and treatment for AML is lengthy and can be very expensive. Medicinal plants and their bioactive molecules are potential candidates for improving human health. In this work, we studied the effect of Ptychotis verticillata (PV) essential oil and its derivatives, carvacrol and thymol, in AML cell lines. We demonstrated that a combination of carvacrol and thymol induced tumor cell death with low toxicity on normal cells. Mechanistically, we highlighted that different molecular pathways, including apoptosis, oxidative,

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O'Connor, Cyril T., Gillian Moon, Walter Böhringer, and Jack C. Q. Fletcher. "Alkylation of Phenol and m-Cresol Over Zeolites." Collection of Czechoslovak Chemical Communications 68, no. 10 (2003): 1949–68. http://dx.doi.org/10.1135/cccc20031949.

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The alkylation of phenols and phenol derivatives such as m-cresol are important reactions in a sequence of syntheses for the production of many important fine chemicals. Specifically it is of great importance to develop catalysts and processes, which are able to selectively produce one or other particular isomer or derivative. This paper presents results of an investigation into the alkylation of phenol and m-cresol, respectively, using methanol in the former case and propene in the latter. The catalysts of choice were H-ZSM-5 and H-MCM-22. In the case of phenol methylation it was found that c

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