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Journal articles on the topic 'Thyroid cancer stem cells'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Lin, Reigh-Yi. "Thyroid cancer stem cells." Nature Reviews Endocrinology 7, no. 10 (2011): 609–16. http://dx.doi.org/10.1038/nrendo.2011.127.

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2

Klonisch, Thomas, Cuong Hoang-Vu, and Sabine Hombach-Klonisch. "Thyroid Stem Cells and Cancer." Thyroid 19, no. 12 (2009): 1303–15. http://dx.doi.org/10.1089/thy.2009.1604.

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3

Guo, Z., H. Hardin, and R. V. Lloyd. "Cancer stem-like cells and thyroid cancer." Endocrine Related Cancer 21, no. 5 (2014): T285—T300. http://dx.doi.org/10.1530/erc-14-0002.

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4

Derwahl, Michael. "Linking Stem Cells to Thyroid Cancer." Journal of Clinical Endocrinology & Metabolism 96, no. 3 (2011): 610–13. http://dx.doi.org/10.1210/jc.2010-2826.

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5

Fierabracci, Alessandra. "Identifying thyroid stem/progenitor cells: advances and limitations." Journal of Endocrinology 213, no. 1 (2011): 1–13. http://dx.doi.org/10.1530/joe-11-0183.

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Continuing advances in stem cell science have prompted researchers to envisage the potential application of stem cells for the management of several debilitating disorders, thus raising the expectations of transplant clinicians. In particular, in order to find a source of adult stem cells alternative to embryonic stem cells (ESCs) for the exploration of novel strategies in regenerative medicine, researchers have attempted to identify and characterise adult stem/progenitor cells resident in compact organs, since these populations appear to be responsible for physiological tissue renewal and reg

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You, Mi-Hyeon. "Mechanism of DAPK1 for Regulating Cancer Stem Cells in Thyroid Cancer." Current Issues in Molecular Biology 46, no. 7 (2024): 7086–96. http://dx.doi.org/10.3390/cimb46070422.

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Death-associated protein kinase 1 (DAPK1) is a calcium/calmodulin (Ca2+/CaM)-dependent serine/threonine (Ser/Thr) protein kinase and is characteristically downregulated in metastatic cancer. Several studies showed that DAPK1 is involved in both the early and late stages of cancer. DAPK1 downregulation is elaborately controlled by epigenetic, transcriptional, posttranscriptional, and posttranslational processes. DAPK1 is known to regulate not only cancer cells but also stromal cells. Recent studies showed that DAPK1 was involved not only in tumor suppression but also in epithelial-mesenchymal t

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Hardin, Heather, Celina Montemayor-Garcia, and Ricardo V. Lloyd. "Thyroid cancer stem-like cells and epithelial-mesenchymal transition in thyroid cancers." Human Pathology 44, no. 9 (2013): 1707–13. http://dx.doi.org/10.1016/j.humpath.2013.01.009.

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8

Thomas, D., S. Friedman, and R. Y. Lin. "Thyroid stem cells: lessons from normal development and thyroid cancer." Endocrine Related Cancer 15, no. 1 (2008): 51–58. http://dx.doi.org/10.1677/erc-07-0210.

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9

Ahn, Soon-Hyun, Ying C. Henderson, Michelle D. Williams, Stephen Y. Lai, and Gary L. Clayman. "Detection of Thyroid Cancer Stem Cells in Papillary Thyroid Carcinoma." Journal of Clinical Endocrinology & Metabolism 99, no. 2 (2014): 536–44. http://dx.doi.org/10.1210/jc.2013-2558.

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Schmohl, Kathrin Alexandra, Andrea Maria Müller, Peter Jon Nelson, and Christine Spitzweg. "Thyroid Hormone Effects on Mesenchymal Stem Cell Biology in the Tumour Microenvironment." Experimental and Clinical Endocrinology & Diabetes 128, no. 06/07 (2019): 462–68. http://dx.doi.org/10.1055/a-1022-9874.

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AbstractNon-classical thyroid hormone signalling via cell surface receptor integrin αvβ3, expressed on most cancer cells and proliferating endothelial cells, has been shown to drive tumour cell proliferation and survival, as well as angiogenesis. Tumours develop within a complex microenvironment that is composed of many different cell types, including mesenchymal stem cells. These multipotent progenitor cells actively home to growing tumours where they differentiate into cancer-associated fibroblast-like cells and blood vessel-stabilising pericytes and thus support the tumour’s fibrovascular n

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11

Grassi, Elisa Stellaria, Viola Ghiandai, and Luca Persani. "Thyroid Cancer Stem-Like Cells: From Microenvironmental Niches to Therapeutic Strategies." Journal of Clinical Medicine 10, no. 7 (2021): 1455. http://dx.doi.org/10.3390/jcm10071455.

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Thyroid cancer (TC) is the most common endocrine malignancy. Recent progress in thyroid cancer biology revealed a certain degree of intratumoral heterogeneity, highlighting the coexistence of cellular subpopulations with distinct proliferative capacities and differentiation abilities. Among those subpopulations, cancer stem-like cells (CSCs) are hypothesized to drive TC heterogeneity, contributing to its metastatic potential and therapy resistance. CSCs principally exist in tumor areas with specific microenvironmental conditions, the so-called stem cell niches. In particular, in thyroid cancer

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12

Gianì, Fiorenza, Veronica Vella, Maria Luisa Nicolosi, et al. "Thyrospheres From Normal or Malignant Thyroid Tissue Have Different Biological, Functional, and Genetic Features." Journal of Clinical Endocrinology & Metabolism 100, no. 9 (2015): E1168—E1178. http://dx.doi.org/10.1210/jc.2014-4163.

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Context: Cancer stem cells from several human malignancies, including poorly differentiated thyroid carcinoma and thyroid cancer cell lines, have been cultured in vitro as sphere-forming cells. These thyroid cancer stem cells were proven to be able to reproduce the original tumor in a xenograft orthotopic model. Objectives: The objective of the study was to characterize papillary thyroid carcinoma (PTC) spheres from well-differentiated thyroid cancer and normal thyroid (NT) spheres obtained from the contralateral thyroid tissue of the same patient. Design: Thyrospheres from PTCs and NTs were i

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Gianì, Fiorenza, Fabio Allia, Maria Antonietta Trovato, Roberta Masto, Gabriella Pellegriti, and Riccardo Vigneri. "Antioxidant Defense Capacity Is Reduced in Thyroid Stem/Precursor Cells Compared to Differentiated Thyrocytes." International Journal of Molecular Sciences 24, no. 14 (2023): 11509. http://dx.doi.org/10.3390/ijms241411509.

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There is much evidence linking oxidative stress to thyroid cancer, and stem cells are thought to play a key role in the tumor-initiating mechanism. Their vulnerability to oxidative stress is unexplored. This study aimed to comparatively evaluate the antioxidant capacity of stem/precursor thyroid cells and mature thyrocytes. Human stem/precursor cells and mature thyrocytes were exposed to increasing concentrations of menadione, an oxidative-stress-producing agent, and reactive oxygen species (ROS) production and cell viability were measured. The expression of antioxidant and detoxification gene

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Gianì, Fiorenza, Giuseppe Pandini, Nunzio Massimo Scalisi, et al. "Effect of low-dose tungsten on human thyroid stem/precursor cells and their progeny." Endocrine-Related Cancer 26, no. 8 (2019): 713–25. http://dx.doi.org/10.1530/erc-19-0176.

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Thyroid cancer incidence is increased in volcanic areas where environment pollution biocontaminates residents. Tungsten (W) is the most increased heavy metal in drinking water of Mount Etna volcanic area where it exceeds the normal range in the urine of 27% inhabitants. The possible connection between increased tungsten and thyroid cancer has never been studied. We investigated in vitro the effect tungsten on both human thyrocytes in primary culture, thyrospheres (aggregates of stem/precursor thyroid cells) and thyrocytes differentiated from tungsten-exposed thyrospheres. Chronic exposure to l

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Vitiello, Michela, Giuseppe Palma, Mario Monaco, et al. "Dual Oncogenic/Anti-Oncogenic Role of PATZ1 in FRTL5 Rat Thyroid Cells Transformed by the Ha-RasV12 Oncogene." Genes 10, no. 2 (2019): 127. http://dx.doi.org/10.3390/genes10020127.

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PATZ1 is a transcriptional factor downregulated in thyroid cancer whose re-expression in thyroid cancer cells leads to a partial reversion of the malignant phenotype, including the capacity to proliferate, migrate, and undergo epithelial-to-mesenchymal transition. We have recently shown that PATZ1 is specifically downregulated downstream of the Ras oncogenic signaling through miR-29b, and that restoration of PATZ1 in Ha-Ras transformed FRTL5 rat thyroid cells is able to inhibit their capacities to proliferate and migrate in vitro. Here, we analyzed the impact of PATZ1 expression on the in vivo

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Onyshchenko, Mykola I., Igor G. Panyutin, Irina V. Panyutin, and Ronald D. Neumann. "Stimulation of Cultured H9 Human Embryonic Stem Cells with Thyroid Stimulating Hormone Does Not Lead to Formation of Thyroid-Like Cells." Stem Cells International 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/634914.

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The sodium-iodine symporter (NIS) is expressed on the cell membrane of many thyroid cancer cells, and is responsible for the radioactive iodine accumulation. However, treatment of anaplastic thyroid cancer is ineffective due to the low expression of NIS on cell membranes of these tumor cells. Human embryonic stem cells (ESCs) provide a potential vehicle to study the mechanisms of NIS expression regulation during differentiation. Human ESCs were maintained on feeder-independent culture conditions. RT-qPCR and immunocytochemistry were used to study differentiation marker expression,125I uptake t

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Caria, Paola, Laura Tronci, Tinuccia Dettori, et al. "Metabolomic Alterations in Thyrospheres and Adherent Parental Cells in Papillary Thyroid Carcinoma Cell Lines: A Pilot Study." International Journal of Molecular Sciences 19, no. 10 (2018): 2948. http://dx.doi.org/10.3390/ijms19102948.

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Papillary thyroid carcinoma (PTC), is characterized by a heterogeneous group of cells, including cancer stem cells (CSCs), crucially involved in tumor initiation, progression and recurrence. CSCs appear to have a distinct metabolic phenotype, compared to non-stem cancer cells. How they adapt their metabolism to the cancer process is still unclear, and no data are yet available for PTC. We recently isolated thyrospheres, containing cancer stem-like cells, from B-CPAP and TPC-1 cell lines derived from PTC of the BRAF-like expression profile class, and stem-like cells from Nthy-ori3-1 normal thyr

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18

Jandu, Danny, Nani Latar, Artida Bajrami, et al. "Single Cell RNA Sequencing of Papillary Cancer Mesenchymal Stem/Stromal Cells Reveals a Transcriptional Profile That Supports a Role for These Cells in Cancer Progression." International Journal of Molecular Sciences 26, no. 10 (2025): 4957. https://doi.org/10.3390/ijms26104957.

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Papillary thyroid cancer (PTC) contains mesenchymal stem/stromal cells (MSCs), but their contribution to PTC progression is not clear. In this study, we compared the transcriptional signatures of normal thyroid (NT) and PTC-derived MSCs with the aim of determining if these have distinct transcriptomes that might influence PTC progression. We used flow cytometry in combination with a panel of MSC clusters of differentiation (CD) markers and showed that both thyroid MSC populations expressed MSC markers and lacked expression of markers not normally expressed by MSCs. In addition, we determined t

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Li, Wen, Ashley N. Reeb, William A. Sewell, George Elhomsy, and Reigh-Yi Lin. "Phenotypic Characterization of Metastatic Anaplastic Thyroid Cancer Stem Cells." PLoS ONE 8, no. 5 (2013): e65095. http://dx.doi.org/10.1371/journal.pone.0065095.

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20

Cicatiello, Annunziata Gaetana, Raffaele Ambrosio, and Monica Dentice. "Thyroid hormone promotes differentiation of colon cancer stem cells." Molecular and Cellular Endocrinology 459 (December 2017): 84–89. http://dx.doi.org/10.1016/j.mce.2017.03.017.

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21

GIUFFRIDA, RAFFAELLA, LUANA ADAMO, GIOACCHIN IANNOLO, et al. "Resistance of papillary thyroid cancer stem cells to chemotherapy." Oncology Letters 12, no. 1 (2016): 687–91. http://dx.doi.org/10.3892/ol.2016.4666.

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22

Peng, Xingqiao, Peiye Zhu, Qiang Zhang, and Jin Li. "The prognostic value of cancer stem cell markers in thyroid cancer: a systematic review." Archives of Medical Science 20, no. 2 (2024): 686–90. http://dx.doi.org/10.5114/aoms/185169.

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IntroductionThyroid cancer stem cells (TCSCs) play a crucial role in the pathogenesis, metastasis, and therapeutic response of thyroid cancer, making them promising biomarkers and potential targets for clinical intervention. This systematic review aims to qualitatively assess the impact of commonly used TCSC markers on the prognosis of thyroid cancer using qualitative methods.Material and methodsIn total, the analysis encompassed five articles.ResultsSix TCSC markers were involved, among which CD133, CD44, CD24, CD15 and ALDH1 were associated with the prognosis of thyroid cancer.ConclusionsHow

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23

Gianì, Fiorenza, Veronica Vella, Dario Tumino, Pasqualino Malandrino, and Francesco Frasca. "The Possible Role of Cancer Stem Cells in the Resistance to Kinase Inhibitors of Advanced Thyroid Cancer." Cancers 12, no. 8 (2020): 2249. http://dx.doi.org/10.3390/cancers12082249.

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Target therapy with various kinase inhibitors (KIs) has been extended to patients with advanced thyroid cancer, but only a subset of these compounds has displayed efficacy in clinical use. However, after an initial response to KIs, dramatic disease progression occurs in most cases. With the discovery of cancer stem cells (CSCs), it is possible to postulate that thyroid cancer resistance to KI therapies, both intrinsic and acquired, may be sustained by this cell subtype. Indeed, CSCs have been considered as the main drivers of metastatic activity and therapeutic resistance, because of their abi

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Gianì, Fiorenza, Roberta Masto, Maria Antonietta Trovato, et al. "Heavy Metals in the Environment and Thyroid Cancer." Cancers 13, no. 16 (2021): 4052. http://dx.doi.org/10.3390/cancers13164052.

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In recent decades, the incidence of thyroid cancer has increased more than most other cancers, paralleling the generalized worldwide increase in metal pollution. This review provides an overview of the evidence supporting a possible causative link between the increase in heavy metals in the environment and thyroid cancer. The major novelty is that human thyroid stem/progenitor cells (thyrospheres) chronically exposed to different metals at slightly increased environmentally relevant concentrations show a biphasic increase in proliferation typical of hormesis. The molecular mechanisms include,

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25

van der Vaart, Jelte, Lynn Bosmans, Hanneke Margo van Santen, Menno R. Vriens, and Hans Clevers. "Generation of Adult Stem Cell Derived Organoid Cultures From Thyroid Follicular Cells." Journal of the Endocrine Society 5, Supplement_1 (2021): A850—A851. http://dx.doi.org/10.1210/jendso/bvab048.1736.

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Abstract The thyroid is essential for maintaining systemic homeostasis by regulating thyroid hormone concentrations in the bloodstream. Due to the limited number of representative model systems, there is limited understanding of fundamental thyroid biology as well as thyroid carcinogenesis. To fill the caveats in the understanding of thyroid cell biology, we aimed to develop an adult stem cell-derived three-dimensional (3D) organoid culture system using murine and human thyroid follicular cells (TFCs). We have succeeded to grow such an organoid culture system that harbours the complete machine

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Crescenzi, Elvira, Antonio Leonardi та Francesco Pacifico. "NF-κB in Thyroid Cancer: An Update". International Journal of Molecular Sciences 25, № 21 (2024): 11464. http://dx.doi.org/10.3390/ijms252111464.

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The dysregulated NF-κB basal activity is a common feature of human thyroid carcinomas, especially in poorly differentiated or undifferentiated forms that, even if rare, are often resistant to standard therapies, and, therefore, are uncurable. Despite the molecular mechanisms leading to NF-κB activation in thyroid cancer being only partially understood, during the last few years, it has become clear that NF-κB contributes in different ways to the oncogenic potential of thyroid neoplastic cells. Indeed, it enhances their proliferation and viability, promotes their migration to and colonization o

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Lee, Woo Kyung, Won Gu Kim, Laura Fozzatti, et al. "Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer." Endocrine-Related Cancer 27, no. 4 (2020): 209–20. http://dx.doi.org/10.1530/erc-19-0482.

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Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy without effective therapeutic options to improve survival. Steroid receptor coactivator-3 (SRC-3) is a transcriptional coactivator whose amplification and/or overexpression has been identified in many cancers. In this study, we explored the expression of SRC-3 in ATCs and the effects of a new class of SRC-3 inhibitor-2 (SI-2) in human ATC cells (THJ-11T and THJ-16T cells) and mouse xenograft models to assess therapeutic potential of SI-2 for the treatment of ATC. SRC-3 protein abundance was significantly higher in human ATC tissue

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28

Davidson, Cole, Jennifer Tomczak, Eyal Amiel, and Frances Carr. "Targeting Glycogen Metabolism as a Novel Therapeutic Approach in Anaplastic Thyroid Cancer." Journal of the Endocrine Society 5, Supplement_1 (2021): A1033—A1034. http://dx.doi.org/10.1210/jendso/bvab048.2115.

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Abstract Effective treatment options for well-differentiated papillary (PTC) and follicular (FTC) thyroid cancers afford positive patient prognoses. The absence of effective interventions for the stem-like, dedifferentiated anaplastic thyroid cancer (ATC) results in poor patient outcomes with a mortality rate higher than all other endocrine cancers combined (1). While receptor tyrosine kinase inhibitors such as sorafenib can extend ATC patient survival, drug resistance and tumor reoccurrence often develop (2). Therefore, there is a critical need for more effective targeted therapies for ATC. A

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Noah A. Mahmood. "Cancer Stem Cell Markers in Iraqi Patients with Solid Tumor: Review Article." Iraqi Journal of Cancer and Medical Genetics 15, no. 1 (2022): 27–36. http://dx.doi.org/10.29409/ijcmg.v15i1.326.

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Cancer stem cells (CSCs) or in another term, tumor intimation cells (TICs), represent a small distinct subpopulations cells within cancer cells which have capability for potential self-regeneration and cell proliferation. During division, TICs or CSCs produced two deferent cell types; one cell is progenitor cell and anther is tumor cell that drive tumor initiation and tumor progression. Previous studies on cancer stem cell markers in solid tumor types that including breast cancer, colon cancer and thyroid cancer have using specific markers to detect cancer stem cells, but it is remain not full

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Li, Zongjuan, Xiangdong Xu, Yizhuo Li, et al. "Synergistic Antitumor Effect of BKM120 with Prima-1Met Via Inhibiting PI3K/AKT/mTOR and CPSF4/hTERT Signaling and Reactivating Mutant P53." Cellular Physiology and Biochemistry 45, no. 5 (2018): 1772–86. http://dx.doi.org/10.1159/000487786.

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Background/Aims: PI3KCA and mutant p53 are associated with tumorigenesis and the development of cancers. NVP-BKM120, a selective pan-PI3K inhibitor, exerts the antitumor activity by suppressing the PI3K signaling pathway. Prima-1Met, a low molecular weight compound, can rescue the gain-of-function of mutant p53 by restoring its transcriptional function. In this study, we investigated whether PI3K inhibition combined with mutant p53 reactivation could enhance the antitumor effect in thyroid cancer cells. Methods: The effects of BKM120 and Prima-1Met on the proliferation, apoptosis, migration an

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31

Rajendran, Ramya Lakshmi, Sanjita Paudel, Prakash Gangadaran, et al. "Extracellular Vesicles Act as Nano-Transporters of Tyrosine Kinase Inhibitors to Revert Iodine Avidity in Thyroid Cancer." Pharmaceutics 13, no. 2 (2021): 248. http://dx.doi.org/10.3390/pharmaceutics13020248.

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A new approach for using extracellular vesicles (EVs) to deliver tyrosine kinase inhibitors (TKIs) to enhance iodine avidity in radioactive iodine-refractory thyroid cancer is needed. We isolated and characterized primary human adipose-derived stem cells (ADSCs) and isolated their EVs. The EVs were characterized by transmission electron microscopy, nanoparticle tracking analysis, and western blotting. A new TKI was loaded into the EVs by incubation (37 °C; 10 min) or sonication (18 cycles; 4 s per cycle) with 2 s intervals and a 2 min ice bath every six cycles. TKI loading was confirmed and me

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32

Chang, Hang-Seok, Yonjung Kim, So Young Lee, Hyeok Jun Yun, Ho-Jin Chang, and Ki Cheong Park. "Anti-Cancer SERCA Inhibitors Targeting Sorafenib-Resistant Human Papillary Thyroid Carcinoma." International Journal of Molecular Sciences 24, no. 8 (2023): 7069. http://dx.doi.org/10.3390/ijms24087069.

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Thyroid cancer is generally curable and, in many cases, can be completely treated, although it can sometimes recur after cancer therapy. Papillary thyroid cancer (PTC) is known as one of the most general subtypes of thyroid cancer, which take up nearly 80% of whole thyroid cancer. However, PTC may develop anti-cancer drug resistance via metastasis or recurrence, making it practically incurable. In this study, we propose a clinical approach that identifies novel candidates based on target identification and validation of numerous survival-involved genes in human sorafenib-sensitive and -resista

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Zane, M., E. Scavo, V. Catalano, et al. "Normal vs cancer thyroid stem cells: the road to transformation." Oncogene 35, no. 7 (2015): 805–15. http://dx.doi.org/10.1038/onc.2015.138.

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Todaro, Matilde, Flora Iovino, Vincenzo Eterno, et al. "Tumorigenic and Metastatic Activity of Human Thyroid Cancer Stem Cells." Cancer Research 70, no. 21 (2010): 8874–85. http://dx.doi.org/10.1158/0008-5472.can-10-1994.

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35

Mirshahidi, Saied, Alfred Simental, Steve C. Lee, et al. "Subpopulations of cancer stem cells found in papillary thyroid carcinoma." Experimental Cell Research 362, no. 2 (2018): 515–24. http://dx.doi.org/10.1016/j.yexcr.2017.12.017.

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Han, Yang, Viktoria F. Koehler, Nathalie Schwenk, et al. "Taking Advantage of the TGFB1 Biology in Differentiated Thyroid Cancer to Stimulate Sodium Iodide Symporter (NIS)-Mediated Iodide Uptake in Engineered Mesenchymal Stem Cells." Journal of the Endocrine Society 5, Supplement_1 (2021): A1033. http://dx.doi.org/10.1210/jendso/bvab048.2114.

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Abstract The sodium iodide symporter (NIS) mediates the active transport of iodide into thyroid follicular cells, providing the basis for the use of radioiodide for diagnostic imaging and therapy of differentiated thyroid cancer and also non-thyroidal tumors after tumor-selective NIS gene transfer. Based on their excellent tumor-homing capacity, mesenchymal stem cells (MSCs) can be employed as tumor-selective NIS gene delivery vehicles. Transgenic expression of NIS in genetically engineered MSCs allows noninvasive imaging of functional NIS expression as well as therapeutic application of 131I.

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You, Mi-Hyeon, Woo Kyung Lee, Meihua Jin, et al. "Death-Associated Protein Kinase 1 Inhibits Progression of Thyroid Cancer by Regulating Stem Cell Markers." Cells 10, no. 11 (2021): 2994. http://dx.doi.org/10.3390/cells10112994.

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The activation of metastatic reprogramming is vital for cancer metastasis, but little is known about its mechanism. This study investigated the potential role of death-associated protein kinase 1 (DAPK1) in thyroid cancer progression. We generated knockdown (KD) DAPK1 using siRNA or shRNA in 8505C and KTC-1 cell lines, which we transiently or stably overexpressed in MDA-T32 and BCPAP cell lines. DAPK1 KD in 8505C and KTC-1 cells significantly increased cell proliferation and colony formation compared with controls. We observed significant inhibition of cancer cell invasion in cells overexpress

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Gianì, Fiorenza, Giulia Russo, Marzio Pennisi, Laura Sciacca, Francesco Frasca, and Francesco Pappalardo. "Computational modeling reveals MAP3K8 as mediator of resistance to vemurafenib in thyroid cancer stem cells." Bioinformatics 35, no. 13 (2018): 2267–75. http://dx.doi.org/10.1093/bioinformatics/bty969.

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Abstract Motivation Val600Glu (V600E) mutation is the most common BRAF mutation detected in thyroid cancer. Hence, recent research efforts have been performed trying to explore several inhibitors of the V600E mutation-containing BRAF kinase as potential therapeutic options in thyroid cancer refractory to standard interventions. Among them, vemurafenib is a selective BRAF inhibitor approved by Food and Drug Administration for clinical practice. Unfortunately, vemurafenib often displays limited efficacy in poorly differentiated and anaplastic thyroid carcinomas probably because of intrinsic and/

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Lu, Yurong, Yiwen Zhu, Shihan Deng, et al. "Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth." Cancers 13, no. 3 (2021): 418. http://dx.doi.org/10.3390/cancers13030418.

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The sonic hedgehog (Shh) pathway plays important roles in tumorigenesis, tumor growth, drug resistance, and metastasis. We and others have reported earlier that this pathway is highly activated in thyroid cancer. However, its role in thyroid cancer stem cell (CSC) self-renewal and tumor development remains incompletely understood. B lymphoma Mo-MLV insertion region 1 homolog (BMI1) and SRY-Box Transcription Factor 2 (SOX2) are two CSC-related transcription factors that have been implicated in promoting CSC self-renewal. The objective of our current investigation was to determine the role of th

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40

Visciano, Carla, Nella Prevete, Federica Liotti, and Gianni Marone. "Tumor-Associated Mast Cells in Thyroid Cancer." International Journal of Endocrinology 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/705169.

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There is compelling evidence that the tumor microenvironment plays a major role in mediating aggressive features of cancer cells, including invasive capacity and resistance to conventional and novel therapies. Among the different cell populations that infiltrate cancer stroma, mast cells (MCs) can influence several aspects of tumor biology, including tumor development and progression, angiogenesis, lymphangiogenesis, and tissue remodelling. Thyroid cancer (TC), the most frequent neoplasia of the endocrine system, is characterized by a MC infiltrate, whose density correlates with extrathyroidal

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Ashtekar, Amruta, Danielle Huk, Alexa Magner, et al. "Sdhd ablation promotes thyroid tumorigenesis by inducing a stem-like phenotype." Endocrine-Related Cancer 24, no. 11 (2017): 579–91. http://dx.doi.org/10.1530/erc-17-0229.

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Mutations in genes encoding enzymes in the tricarboxylic acid cycle (TCA, also known as the Krebs cycle) have been implicated as causative genetic lesions in a number of human cancers, including renal cell cancers, glioblastomas and pheochromocytomas. In recent studies, missense mutations in the succinate dehydrogenase (SDH) complex have also been proposed to cause differentiated thyroid cancer. In order to gain mechanistic insight into this process, we generated mice lacking the SDH subunit D (Sdhd) in the thyroid. We report that these mice develop enlarged thyroid glands with follicle hyperc

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Mirshahidi, Saied, Isabella J. Yuan, Alfred Simental, et al. "Targeting Tumor Microenvironment Akt Signaling Represents a Potential Therapeutic Strategy for Aggressive Thyroid Cancer." International Journal of Molecular Sciences 24, no. 6 (2023): 5471. http://dx.doi.org/10.3390/ijms24065471.

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Effects of the tumor microenvironment (TME) stromal cells on progression in thyroid cancer are largely unexplored. Elucidating the effects and underlying mechanisms may facilitate the development of targeting therapy for aggressive cases of this disease. In this study, we investigated the impact of TME stromal cells on cancer stem-like cells (CSCs) in patient-relevant contexts where applying in vitro assays and xenograft models uncovered contributions of TME stromal cells to thyroid cancer progression. We found that TME stromal cells can enhance CSC self-renewal and invasiveness mainly via the

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LAN, LING, YONG LUO, DAI CUI, et al. "Epithelial-mesenchymal transition triggers cancer stem cell generation in human thyroid cancer cells." International Journal of Oncology 43, no. 1 (2013): 113–20. http://dx.doi.org/10.3892/ijo.2013.1913.

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Wen, Bojie. "Therapeutic role of dabrafenib on thyroid cancer." Theoretical and Natural Science 62, no. 1 (2024): 12–18. http://dx.doi.org/10.54254/2753-8818/62/20241456.

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Abstract. Thyroid cancer, which has a high prevalence of BRAF V600E mutations, is the ninth most frequent cancer worldwide, especially in the aggressive anaplastic thyroid cancer (ATC). The mutation causes continual activation of the MAPK pathway, resulting in unrestricted cell multiplication that leads to the development of tumors. The therapeutic potential of a selective BRAF V600E inhibitor, dabrafenib, has been approved in the treatment of thyroid cancer, especially ATC. The efficacy of dabrafenib was investigated by analyzing various in vivo and in vitro studies and clinical trials. The t

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Bleuer, Juerg P., Theodor Abelin, Yuri I. Averkin, and Aleksei E. Okeanov. "The epidemiological situation of thyroid cancer in belarus." STEM CELLS 15, S1 (2009): 251–54. http://dx.doi.org/10.1002/stem.5530150733.

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Vicari, Luisa, Cristina Colarossi, Dario Giuffrida, Ruggero De Maria, and Lorenzo Memeo. "Cancer stem cells as a potential therapeutic target in thyroid carcinoma." Oncology Letters 12, no. 4 (2016): 2254–60. http://dx.doi.org/10.3892/ol.2016.4936.

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Abu-Bonsrah, Kwaku Dad, Donald F. Newgreen, and Mirella Dottori. "Development of Functional Thyroid C Cell-like Cells from Human Pluripotent Cells in 2D and in 3D Scaffolds." Cells 10, no. 11 (2021): 2897. http://dx.doi.org/10.3390/cells10112897.

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Medullary thyroid carcinoma contributes to about 3–4% of thyroid cancers and affects C cells rather than follicular cells. Thyroid C cell differentiation from human pluripotent stem cells has not been reported. We report the stepwise differentiation of human embryonic stem cells into thyroid C cell-like cells through definitive endoderm and anterior foregut endoderm and ultimobranchial body-like intermediates in monolayer and 3D Matrigel culture conditions. The protocol involved sequential treatment with interferon/transferrin/selenium/pyruvate, foetal bovine serum, and activin A, then IGF-1 (

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Shin, Hye‐Ji, Kyung‐A Hwang, Ryeo‐Eun Go, Seung U. Kim, and Kyung‐Chul Choi. "Antithyroid cancer effects of human neural stem cells expressing therapeutic genes on anaplastic thyroid cancer cells." Journal of Cellular Biochemistry 121, no. 2 (2019): 1586–98. http://dx.doi.org/10.1002/jcb.29393.

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Khan, Abdul Q., Eiman I. Ahmed, Noor Elareer, et al. "Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway." International Journal of Molecular Sciences 21, no. 2 (2020): 438. http://dx.doi.org/10.3390/ijms21020438.

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The constitutive activation of Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signal transduction is well elucidated in STAT3-mediated oncogenesis related to thyroid cancer and is considered to be a plausible therapeutic target. Hence, we investigated whether curcumin, a natural compound, can target the JAK/STAT3 signaling pathway to induce cytotoxic effects in papillary thyroid cancer (PTC) cell lines (BCPAP and TPC-1) and derived thyroid cancer stem-like cells (thyrospheres). Curcumin suppressed PTC cell survival in a dose-dependent manner via the induction of caspa

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Revilla, Giovanna, Rosa Corcoy, Antonio Moral, Joan Carles Escolà-Gil, and Eugenia Mato. "Cross-Talk between Inflammatory Mediators and the Epithelial Mesenchymal Transition Process in the Development of Thyroid Carcinoma." International Journal of Molecular Sciences 20, no. 10 (2019): 2466. http://dx.doi.org/10.3390/ijms20102466.

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There is strong association between inflammatory processes and their main metabolic mediators, such as leptin, adiponectin secretion, and low/high-density lipoproteins, with the cancer risk and aggressive behavior of solid tumors. In this scenario, cancer cells (CCs) and cancer stem cells (CSCs) have important roles. These cellular populations, which come from differentiated cells and progenitor stem cells, have increased metabolic requirements when it comes to maintaining or expanding the tumors, and they serve as links to some inflammatory mediators. Although the molecular mechanisms that ar

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