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Journal articles on the topic 'Thyroid Diseases, drug therapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Kravchun, Nonna, Inna Dunaieva, and Olexander Kozakov. "PERSONALIZED THYROID HYPOFUNCTION THERAPY STRATEGY." Problems of Endocrine Pathology 77, no. 3 (2021): 120–25. http://dx.doi.org/10.21856/j-pep.2021.3.17.

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In the current conditions, coronavirus infection is often the cause of the development of inflammatory and autoimmune diseases of the thyroid gland. One of these diseases can be subclinical hypothyroidism — the initial stage of development of manifest hypothyroidism. Signs of hypothyroidism include weight gain, edema, decreased mental activity, increased drowsiness, dry skin, bradycardia, cardiomyopathy, constipation, muscle cramps, and paraesthesia. Because SG is asymptomatic by definition, 25–50% of patients have slow but characteristic signs of hypothyroidism, manifested by disorders of man

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Kravchun, Nonna, Inna Dunaieva, and Olexander Kozakov. "PERSONALIZED THYROID HYPOFUNCTION THERAPY STRATEGY." Problems of Endocrine Pathology 77, no. 3 (2021): 120–25. http://dx.doi.org/10.21856/j-pep.2021.3.17.

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In the current conditions, coronavirus infection is often the cause of the development of inflammatory and autoimmune diseases of the thyroid gland. One of these diseases can be subclinical hypothyroidism — the initial stage of development of manifest hypothyroidism. Signs of hypothyroidism include weight gain, edema, decreased mental activity, increased drowsiness, dry skin, bradycardia, cardiomyopathy, constipation, muscle cramps, and paraesthesia. Because SG is asymptomatic by definition, 25–50% of patients have slow but characteristic signs of hypothyroidism, manifested by disorders of man

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3

Ilyés, István. "Current questions of thyroid diseases in childhood." Orvosi Hetilap 152, no. 16 (2011): 617–27. http://dx.doi.org/10.1556/oh.2011.29088.

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In recent years our knowledge on thyroid diseases in childhood has been increased. Several forms of congenital hypothyroidism (dysgenesis, dyshormongenesis, thyrotropin resistance and some central forms) are consequences of gene mutations. Maternal hypothyroxinemia due to severe iodine deficiency leads to early neurological damage and congenital hypothyroidism. Neonatal screening of congenital hypothyroidism and early treatment with l-thyroxin ensure good prognosis. Differential diagnosis of the various forms of congenital hypothyroidism in newborns is not an easy task. The need for treatment

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Kvachenyuk, A. M., та E. L. Kvachenyuk. "Использование фитотерапии при лечении заболеваний щитовидной железы". Likarska sprava, № 3-4 (26 червня 2012): 99–104. http://dx.doi.org/10.31640/ls-2012-(3-4)-18.

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The main tasks during treatment of hyperplastic thyroid diseases – to stop the growth of thyroid nodules; compensation of hypothyrosis; normalization of thyroid size. One of the perspective methods in combine therapy of diffuse and mix goiter is a phytotherapy. The most often for thyroid diseases we have used the plant drug Polentilla alba, which on Ukrainian market was registered as "Alba®". Investigation has shown, that phytodrug of Polentilla alba could be recommended for monotherapy and for combine conservative therapy of diffuse and mix benign euthyroid goiter, and also for complex treatm

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Cabanillas, Maria E., Mimi I. Hu, Jean-Bernard Durand, and Naifa L. Busaidy. "Challenges Associated with Tyrosine Kinase Inhibitor Therapy for Metastatic Thyroid Cancer." Journal of Thyroid Research 2011 (2011): 1–9. http://dx.doi.org/10.4061/2011/985780.

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Tyrosine kinase inhibitors (TKIs) which target angiogenesis are promising treatments for patients with metastatic medullary and differentiated thyroid cancers. Sorafenib, sunitinib, and pazopanib are commercially available drugs which have been studied in these diseases. Vandetanib is the first drug approved in the United States for treatment of medullary thyroid cancer. These TKIs are used as chronic therapies, and therefore it is imperative to understand the adverse event profile in order to avoid excessive toxicity and maintain patients on therapy as long as it proves beneficial. Here we re

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Guseinova, R. M., A. A. Prosvirnina, M. O. Korchagina, A. A. Trukhin, and M. S. Sheremeta. "Thyrotoxicosis in a patient with Turner syndrome: radioactive iodine therapy." Problems of Endocrinology 68, no. 6 (2022): 49–58. http://dx.doi.org/10.14341/probl13132.

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Turner syndrome (TS) is a chromosomal disorder affecting female and characterized by complete or partial monosomy of the X chromosome. These genetic changes lead to the abnormalities in growth and development and increase the risk of autoimmune diseases, including those affecting the thyroid. Thyroid pathology in TS may include autoimmune thyroiditis, hypothyroidism, thyrotoxicosis (Graves disease, AIT in the hyperthyroid state).Thyrotoxicosis is the clinical syndrome of excess circulating thyroid hormones. One of the main causes of thyrotoxicosis is Graves’ disease (GD), an organ-specific aut

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Ward, Laura S. "The difficult patient: drug interaction and the influence of concomitant diseases on the treatment of hypothyroidism." Arquivos Brasileiros de Endocrinologia & Metabologia 54, no. 5 (2010): 435–42. http://dx.doi.org/10.1590/s0004-27302010000500002.

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Although most hypothyroid patients do well with one single tablet of thyroxine daily, approximately 10% are dissatisfied and another important group of patients is difficult to control. We reviewed the most common causes for frequent-dose adjustment or high-dose requirement, including poor compliance with therapy and inadequate medication. Since these two causes have been ruled out, drug interaction and other concomitant diseases need to be investigated. Requirements of thyroxine increase in all conditions characterized by impaired gastric acid secretion. Proton-pump inhibitors, antacids and a

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Rashidi, Homiera, Bahman Ghaderian, Alireza Sedaghat, Mahmoud Latifi, and Zohre Naimi. "Effect of iodine-therapy on hyperthyroidism patients without pre-administration of anti-thyroid therapeutic options." Bionatura 7, no. 1 (2022): 1–5. http://dx.doi.org/10.21931/rb/2022.07.01.7.

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Anti-thyroid treatment and radioiodine are mainly used treatments for patients with thyrotoxicosis. The effect of anti-thyroid drugs (ATDs) on radioactive iodine's therapeutic effectiveness in hyperthyroidism remains controversial. This study aimed to determine the treatment effectiveness and complications in patients with thyrotoxicosis receiving radioiodine treatment with or without adjunctive anti-thyroid drugs in a tertiary endocrinology center in Ahvaz, Iran. A total of 165 patients with thyrotoxicosis (50 males and 115 females) were recruited in this retrospective clinical study. These p

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Martirosyan, N. S., A. A. Tulskiy, Yu О. Matveyeva, et al. "Replacement Therapy for Hypothyroidism: Purpose and Indication for Correction." Effective Pharmacotherapy 20, no. 8 (2024): 64–69. http://dx.doi.org/10.33978/2307-3586-2024-20-8-64-69.

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Hypothyroidism syndrome remains the most common form of thyroid dysfunction, accompanied by a decrease in the level of thyroid hormones in the blood and a variety of clinical manifestations on the part of almost all organs and systems. The development of a synthetic levorotatory thyroxine isomer and the discovery of the peripheral conversion of thyroxine to active triiodothyronine made it possible to propose monotherapy with sodium levothyroxine as the gold standard for the treatment of hypothyroidism of any etiology. The main principle of treatment of hypothyroidism syndrome is the replacemen

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Melnichenko, Galina A., Anastasiya A. Glibka, and Olga Y. Demicheva. "Thyroid dysfunction following immune reconstitution therapy." Clinical and experimental thyroidology 15, no. 4 (2020): 156–61. http://dx.doi.org/10.14341/ket12225.

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Medication effects on the immune system often lead to the development of adverse events such as autoimmune diseases. The thyroid gland is organ whose embryonic development features are predisposed spontaneous and induced lesions with various autoimmune effects. Cytokinin-induced thyroiditis (in 5070% of cases proceeds as a destructive thyroiditis), thyroid dysfunction following immune checkpoint inhibitors (using the combined treatment CTLA-4 + PD-1/PD-L1 leads to an increase hypothyroidism rates up to 20%). Some researchers presume that can develop thyroid dysfunction following treatmen

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Berihanova, RR, and IA Minenko. "Interrelation of non-drug correction of menopausal disorders and functioning of the pituitary-thyroid system in women with metabolic syndrome." TARGETED ONCOTHERAPY, no. 2 (April 11, 2019): 81–88. http://dx.doi.org/10.24075/brsmu.2019.023.

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In perimenopausal women, the frequency of thyroid diseases and metabolic syndrome (MS) increases. In this work, the effect of non-drug correction programs for menopausal disorders on the structural and functional state of the thyroid gland in patients with MS was evaluated. For that, five groups of women (330 people total) aged 45–50 years with climacteric syndrome (CS) against the background of MS were examined. For the index group and the experimental groups the following was used: basic treatment, exercise therapy, drinking balneotherapy, additional oral intake of multivitamins and minerals

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Bai, Xuefeng, Xiaoyu Chen, Xiaohong Wu, Yinqiong Huang, Yong Zhuang, and Xiahong Lin. "Immune checkpoint inhibitor-associated thyroid dysfunction: a disproportionality analysis using the WHO Adverse Drug Reaction Database, VigiBase." European Journal of Endocrinology 182, no. 1 (2020): 1–9. http://dx.doi.org/10.1530/eje-19-0535.

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Objective Our study aimed to identify and characterize thyroid dysfunctions associated with immune checkpoint inhibitors (ICIs). Design Data were obtained from VigiBase, between January 1, 2011 to March 6, 2019. Methods All thyroid drug-adverse events are classified by group queries according to the Medical Dictionary for Regulatory Activities. Information component (IC) and reporting odds ratio (ROR) were considered as measures of disproportionality for the assessment of association between ICIs and thyroid dysfunctions. We used IC to identify meaningful drug-adverse events while using ROR to

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Fokina, E. A., and A. O. Shpakov. "Thyroid diseases and new approaches for their treatment." Siberian Journal of Clinical and Experimental Medicine 37, no. 3 (2022): 90–97. http://dx.doi.org/10.29001/2073-8552-2022-37-3-90-97.

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The prevalence of thyroid diseases including autoimmune hyperthyroidism (Graves’ disease), autoimmune thyroiditis, and diff erent forms of thyroid cancer is increasing every year, while the eff ectiveness of their treatment remains low and is limited, mainly, to replacement therapy with thyroid hormones and surgical and radioisotope methods. This review presents the current state of the problem of pharmacological correction in thyroid diseases including new approaches to the regulation of the functional activity of the components of the thyroid hormone synthesis system in thyroid follicular ce

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Ros, Muhammad Faiz Che, Noor Rafhati Adyani Abdullah, and Samuel Yee Siew Mun. "RADIOACTIVE IODINE THERAPY FOR BENIGN THYROID DISORDERS." Journal of the ASEAN Federation of Endocrine Societies 38, S2 (2023): 17. https://doi.org/10.15605/jafes.038.s2.17.

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INTRODUCTIONRadioactive iodine (I-131) (RAI) has been used to treat hyperthyroidism since the early 1940s. Its action causes permanent destruction to the thyroid tissue by emitting radiation of two forms, gamma and beta rays. Gamma radiation effects are more useful for diagnostic purposes, whereas beta radiation effects are therapeutic. RAI is indicated as a definitive therapy for benign thyroid diseases (Graves’ disease, toxic multinodular goitre (TMNG) and toxic adenoma). The purpose of the study is to evaluate the outcomes of RAI for benign thyroid disorders in our centre. METHODOLOGYWe con

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Marano, Francesca, Roberto Frairia, Letizia Rinella, et al. "Combining doxorubicin-nanobubbles and shockwaves for anaplastic thyroid cancer treatment: preclinical study in a xenograft mouse model." Endocrine-Related Cancer 24, no. 6 (2017): 275–86. http://dx.doi.org/10.1530/erc-17-0045.

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Anaplastic thyroid cancer is one of the most lethal diseases, and a curative therapy does not exist. Doxorubicin, the only drug approved for anaplastic thyroid cancer treatment, has a very low response rate and causes numerous side effects among which cardiotoxicity is the most prominent. Thus, doxorubicin delivery to the tumor site could be an import goal aimed to improve the drug efficacy and to reduce its systemic side effects. We recently reported that, in human anaplastic thyroid cancer cell lines, combining doxorubicin-loaded nanobubbles with extracorporeal shock waves, acoustic waves us

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Dressler, J., F. Grünwald, B. Leisner, et al. "Guideline for radioiodine therapy for benign thyroid diseases (version 4)." Nuklearmedizin 46, no. 05 (2007): 220–23. http://dx.doi.org/10.1160/nukmed-0287.

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SummaryVersion 4 of the guideline for radioiodine therapy for benign thyroid diseases includes an interdisciplinary consensus on decision making for antithyroid drugs, surgical treatment and radioiodine therapy. The quantitative description of a specific goiter volume for radioiodine therapy or operation was cancelled. For patients with nodular goiter with or without autonomy, manifold circumstances are in favor of surgery (suspicion on malignancy, large cystic nodules, mediastinal goiter, severe compression of the trachea) or in favor of radioiodine therapy (treatment of autonomy, age of pati

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17

Signore, Alberto, Kelly Luz Anzola, Sveva Auletta, et al. "Current Status of Molecular Imaging in Inflammatory and Autoimmune Disorders." Current Pharmaceutical Design 24, no. 7 (2018): 743–53. http://dx.doi.org/10.2174/1381612824666180130115153.

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In the field of inflammation imaging, nuclear medicine techniques can be considered as a non-invasive tool to early detect pathophysiological changes in affected tissues. These changes usually occur before clinical onset of symptoms and before the development of anatomical changes, that are commonly detected by radiological procedures. This is particularly important for prognostic purposes, therapy decision making and for therapy follow-up. Here we review the current state-of-the art of nuclear medicine for diagnostic purposes in different conditions characterized by a chronic inflammation, su

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Drogashevskaya, Natalya V., Ekaterina A. Zhilina, Narine S. Martirosyan, et al. "Predicting remission of Graves' disease following treatment with antithyroid drugs." Clinical review for general practice 4, no. 4 (2023): 6–12. http://dx.doi.org/10.47407/kr2023.4.4.00250.

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Graves' disease (GD) is among the most prevalent organ-specific diseases and is one of the most common causes of hyperthyroidism in regions with normal iodine supply. Current therapeutic strategies for the treatment of patients with GD include antithyroid drugs (ATD), thyroid ablation with radioiodine and surgery, which of them is associated with certain risks of complications. The main task of the doctor is to choose the most optimal method to achieve stable remission. In this regard, much attention is paid to the study of predictors of remission, especially after antithyroid drug treatment d

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Dressler, J., F. Grünwald, B. Leisner, et al. "Guideline for radioiodine therapy for benign thyroid diseases (version 3)." Nuklearmedizin 43, no. 06 (2004): 217–20. http://dx.doi.org/10.1055/s-0038-1623919.

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SummaryThe version 3 of the guideline for radioiodine therapy for benign thyroid diseases presents first of all a revision of the version 2. The chapter indication for radioiodine therapy, surgical treatment or antithyroid drugs bases on an interdisciplinary consensus. The manifold criteria for decision making consider the entity of thyroid disease (autonomy, Graves’ disease, goitre, goitre recurrence), the thyroid volume, suspicion of malignancy, cystic nodules, risk of surgery and co-morbidity, history of subtotal thyroidectomy, persistent or recurrent thyrotoxicosis caused by Graves’ diseas

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Kryukov, E. V., N. P. Potekhin, A. N. Fursov, et al. "Algorithm of management of patients treated with amiodarone depending on thyroid functional state." Clinical Medicine (Russian Journal) 95, no. 10 (2017): 901–5. http://dx.doi.org/10.18821/0023-2149-2017-95-10-901-905.

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Cardiac arrhythmias are common symptoms of various cardiovascular diseases. Currently, amiodarone is considered to be one of the most efficient and safe antiarrhythmic drugs. Long-term use of amiodarone having the chemical structure similar to that of thyroxine can cause disturbances in the functional state of the thyroid gland. 32 (6.9 percent) of the 462 patients who used the drug for more than six months developed amiodarone-associated thyrotoxicosis and 11 (2,5%) one amiodarone-associated hypothyroidism. Most patients with hyperthyroidism, 22 (68,8%), did not have any structural pathology

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Shkala, L. V., T. Y. Malchevska, O. M. Plienova, and O. V. Shkala. "Amiodarone-induced thyrotoxicosis type 1 during the treatment of cardiovascular diseases: features of a clinical case." INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 20, no. 5 (2024): 400–406. http://dx.doi.org/10.22141/2224-0721.20.5.2024.1427.

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Background. Treatment of patients with comorbid pathology, including hypertension, coronary heart disease with atrial fibrillation, often requires the use of amiodarone. Unfortunately, the latter in some cases is accompanied by complications, including thyroid dysfunction. The most serious situation develops when amiodarone-induced thyrotoxicosis occurs, which leads to an additional toxic effect on the myocardium and changes in the sensitivity of the cardiovascular system to catecholamines. The manifestation of amiodarone-induced thyrotoxicosis is not always typical, which causes certain diff

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Salsabila, Arina, Ulfa Kholili, and Hermina Novida. "Drug-Induced Liver Injury (DILI) related to Propylthiouracil (PTU) in hyperthyroidism with liver cirrhosis." Bali Medical Journal 12, no. 2 (2023): 1594–600. http://dx.doi.org/10.15562/bmj.v12i2.4206.

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Link of Video Abstract: https://youtu.be/_dm9Vyddxvg Background: Hyperthyroidism is an excessive concentration of thyroid hormone in tissues caused by increased thyroid hormone synthesis, excessive thyroid hormone release, or an endogenous or exogenous extrathyroid source. There are 3 types of hyperthyroid therapy: antithyroid drugs (PTU, thiamazole, and carbimazole), radioactive ablation, and surgery. However, PTU is one of the drugs included in the list of medications that cause Drug-induced Liver Injury (DILI). Case Presentation: A-36-years old male came to the IRD Dr. Sutomo General Hospit

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Maksim, Oksana V., Vladimir V. Salukhov, and Boris V. Romashevskiy. "Prospects for targeted therapy of Graves' disease: A review." Consilium Medicum 26, no. 4 (2024): 238–45. http://dx.doi.org/10.26442/20751753.2024.4.202764.

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The high prevalence of autoimmune thyroid diseases and the low effectiveness of treatment are the great of the reasons for long-term disability and high disability of patients. Significant progress in the study of immunological mechanisms of the development of autoimmune thyroid pathology has been achieved. These findings evidences provide new directions in the treatment of these diseases. Graves' disease is a classic autoimmune disease characterized by the formation of stimulating antibodies to the thyroid-stimulating hormone receptor and manifested by the thyrotoxicosis clinic. The main meth

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Mangaku, Albertian, Weny I. Wiyono, and Deby A. Mpila. "Evaluasi Penggunaan dan Potensi Interaksi Obat pada Pasien Gangguan Tiroid." e-CliniC 12, no. 3 (2024): 454–61. https://doi.org/10.35790/ecl.v12i3.56453.

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Abstract: Thyroid disorders are diseases that occur when the thyroid gland undergoes changes in shape (goiter or nodules) and function (hypothyroidism and hyperthyroidism). Rational drug use must be appropriate in terms of indication, patient, drug, and dose. Drug interactions are one of the issues that affect the success of therapy and have the potential to cause therapeutic failure. This study aimed to evaluate drug use and the potential for drug interactions in patients with thyroid disorders. This was a descriptive and observational study with retrospective data collection from medical rec

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Gardas, Andrzej, and Kathleen L. Rives. "Enzyme-linked immunosorbent assay of autoantibodies reacting with thyroid plasma membrane antigens in sera of patients with autoimmune thyroid diseases." Acta Endocrinologica 113, no. 2 (1986): 255–60. http://dx.doi.org/10.1530/acta.0.1130255.

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Abstract. A sensitive and specific enzyme-linked immunosorbent assay (ELISA) for the detection of autoantibodies reacting with thyroid plasma membrane antigens has been established. Autoantibodies reacting with thyroid plasma membrane antigens were detected by the ELISA in 95% of untreated hyperthyroid Graves', 68% of antithyroid drug-treated Graves' up to four months of the therapy, in 62% of Hashimoto's thyroiditis and in 8.9% of toxic nodular goitre. The ELISA was negative in 100% healthy blood donors, 100% non-toxic nodular goitre, in 12 patients with rheumatoid arthritis, 18 patients with

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Verbovoy, A. F., and Yu A. Dolgikh. "Hypothyroidism in a physician’s practice: difficulties of diagnostics and treatment." Medical Council, no. 21 (January 28, 2020): 206–12. http://dx.doi.org/10.21518/2079-701x-2019-21-206-212.

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Hypothyroidism is the most common endocrine disease after diabetes mellitus. Its frequency depends on age, sex and iodine intake. The highest prevalence of hypothyroidism is observed in older women. Chronic autoimmune thyroiditis is the most common cause of this condition. The peculiarity of hypothyroidism is an erased clinical picture, diversity and nonspecific symptoms. This makes it difficult to diagnose the disease, leads to an erroneous diagnosis and later detection of thyroid insufficiency. This article discusses the various «masks» of hypothyroidism and peculiarities of clinical manifes

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Krikunova, Liudmila I., Liana S. Mkrtchian, Irina A. Zamulaeva, et al. "Correction of oxidative stress with glutathione-based agents in women with hyperproliferative diseases living in radiation-contaminated areas: A prospective study." Gynecology 27, no. 2 (2025): 121–28. https://doi.org/10.26442/20795696.2025.2.203292.

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Background. Women living in the territories of the Russian Federation contaminated with radionuclides as a result of the accident at the Chernobyl nuclear power plant are exposed to a complex of environmental, psychological, and socio-economic factors. The high prevalence of hyperproliferative diseases (HPD) reported in this population may be due to, among other things, the oxidative stress, which initiates carcinogenesis. In these settings, the search for drugs that adjust the antioxidant system can be not only an effective strategy for non-hormonal accompanying therapy, but also the key to t

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Kumar, Kunal D., Mahesh G. Solu, Ankit P. Kakadiya, Arpit V. Patel, Sumer S. Ramawat, and Vishwakiran . "A study of thyroid dysfunction in patients with type 2 diabetes mellitus at new civil hospital, Surat, Gujarat, India." International Journal of Advances in Medicine 7, no. 4 (2020): 678. http://dx.doi.org/10.18203/2349-3933.ijam20201122.

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Background: Thyroid diseases and diabetes mellitus, as comorbid condition these together throw a great burden to medicine and humanity. Considering the ever increasing population of diabetics in our country and the significant causal relationship established by current literature, this study was undertaken.Methods: A thorough clinical history regarding diabetes mellitus (onset, duration), any history of long-term illness, any previous thyroid dysfunction, previous history of any kind of drug therapy, whether the patient was on insulin or oral hypoglycaemic drugs was sought. All diabetic patien

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Kolpakova, E. A., A. R. Elfimova, L. V. Nikankina, I. N. Dyakov, K. K. Bushkova, and E. A. Troshina. "COVID-19 and the possible development of autoimmune thyroid diseases." Clinical and experimental thyroidology 18, no. 3 (2023): 4–12. http://dx.doi.org/10.14341/ket12740.

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In the midst of continuing coronavirus infection (COVID-19) there has been an increase in the incidence of various autoimmune pathologies. Particular attention to the potential relationship between coronavirus infection and autoimmune diseases is attracted by the positive therapeutic effect of the treatment of severe forms of COVID-19 with drugs used in the treatment of rheumatologically diseases.The results of the study should be the starting point for understanding the mechanisms of possible breakdown of immunological tolerance and the development of autoimmune thyroid diseases.AIM: To asses

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K.P.R., Chowdary* G.Sumalatha K. Dhanavardhan K. Prathyusha. "A PROSPECTIVE OBSERVATIONAL STUDY ON PRESCRIPTION PATTERN DRUG UTILIZATION AND AUDIT FOR THE TREATMENT OF DIABETIES MELLITUS IN A TERTIARY CARE HOSPITAL IN ANDHRA PRADESH." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1613–18. https://doi.org/10.5281/zenodo.821052.

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Introduction: Diabetes is the most common metabolic disorder in Indian community. It is a silent disease that has become more prevalent with increased age. Despite the advances in understanding the disease and its management, the mortality and morbidity of the disease is increasing.Objective: The objective of the study is to evaluate the prescription pattern, drug utilization and audit for the treatment of diabetes mellitus in a tertiary care hospital in Rajahmundry. Methodology: The study design is a prospective observational study. A total of 150 cases related to anti diabetic treatment were

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Panova, E. A., V. A. Serov, A. M. Shutov, N. N. Bakumtseva, and M. Yu Kuzovenkova. "POLYPHARMACY IN ELDERLY OUT PATIENTS." Ulyanovsk Medico-biological Journal, no. 2 (June 10, 2019): 16–22. http://dx.doi.org/10.34014/2227-1848-2019-2-16-22.

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The aim of the work is to study the daily practice of prescribing drugs at the outpatient stage of medical care and to analyze the data obtained based Beers 2012 criteria and STOPP / START version 1. Materials and Methods. The authors analyzed drug prescriptions for 150 outpatients, who were over 65 years old. Results. Cardiovascular diseases, diseases of the osteo-articular system and type 2 diabetes mellitus prevailed in the morbidity structure of patients. Oncological diseases, thyroid diseases, bronchial asthma, cataracts, pancreatitis, anemia, peptic ulcer disease were diagnosed in some p

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Komatsuda, Hiroki, Michihisa Kono, Risa Wakisaka, et al. "Harnessing Immunity to Treat Advanced Thyroid Cancer." Vaccines 12, no. 1 (2023): 45. http://dx.doi.org/10.3390/vaccines12010045.

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The incidence of thyroid cancer (TC) has increased over the past 30 years. Although differentiated thyroid cancer (DTC) has a good prognosis in most patients undergoing total thyroidectomy followed by radioiodine therapy (RAI), 5–10% of patients develop metastasis. Anaplastic thyroid cancer (ATC) has a low survival rate and few effective treatments have been available to date. Recently, tyrosine kinase inhibitors (TKIs) have been successfully applied to RAI-resistant or non-responsive TC to suppress the disease. However, TC eventually develops resistance to TKIs. Immunotherapy is a promising t

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Bardychevskyi, Dmytro, Violetta Yuzvenko, and Oleksandr Tovkai. "Modern diagnosis and treatment of papillary thyroid cancer." Ukrainian Scientific Medical Youth Journal 141, no. 3 (2023): 97–102. http://dx.doi.org/10.32345/usmyj.3(141).2023.97-102.

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thyroid cancer is the most common malignant tumor of the endocrine glands, accounting for 1% of all cases of malignant neoplasms. According to the National Cancer Registry, 24,626 patients with thyroid cancer were identified in Ukraine for the period from 2014 to 2021, of which 4,556 were men (18.5%) and 20,070 were women (81.5%). Treatment of papillary thyroid cancer combines three methods: surgery, the use of radioiodine therapy, and hormone replacement therapy with levothyroxine drugs. The aim of this work, based on the example of a clinical case, was to analyze the patient's route, methods

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Moka, D., M. Schmidt, P. Theissen, H. Schicha, and M. Dietlein. "Prevention, screening and therapy of thyroid diseases and their cost-effectiveness." Nuklearmedizin 42, no. 05 (2003): 181–89. http://dx.doi.org/10.1055/s-0038-1625188.

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Summary:Cost-effectiveness analyses focused on benign thyroid diseases are under-represented in the literature. The calculation of costs per additionally gained life year is difficult: The benefit of prevention is shifted into the distant future. The influence of an untreated subclinical thyroid disease on life expectancy can only be demonstrated by a long-term follow-up and by epidemiological databases. Iodine supplementation and programs for the prevention of tobacco smoking (primary prevention) are very cost-effective. Smoking increases the risk both of multinodular goiter and of Graves’ di

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Huff, W., M. Dietlein, C. Kobe, H. Schicha, and M. Schmidt. "Interactions between brain, psyche and thyroid." Nuklearmedizin 47, no. 06 (2008): 225–34. http://dx.doi.org/10.3413/nukmed-0191.

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SummaryInteractions between brain, psyche and thyroid are known from historical descriptions of thyroidectomy (Kocher) and hyperthyroidism. However, their importance is often underscored in clinical routine. Thyroid hormone deficiency during pregnancy may result in irreversible mental retardation and requires levothyroxine substitution. TSH screening after delivery must identify newborns with congenital hypothyroidism: An early levothyroxine substitution and long term therapy control are required.Hypothyroidism and depression have many symptoms in common. Cognitive deficits and depressive stat

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Lapcevic, Mirjana. "Autoimmune thyroid disease and associated diseases." Srpski arhiv za celokupno lekarstvo 133, Suppl. 1 (2005): 84–87. http://dx.doi.org/10.2298/sarh05s1084l.

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Autoimmune thyroid disease (ATD) is a multifactorial, genetic disease. It is the sequelae of the impaired immunoregulation, tolerance and poor recognition of one?s own proteins, oligopolysaccharides and polypeptides, due to development of somatic lymphocyte mutations. It is manifested by different clinical and morphological entities, inter-related by etiopathogenetic association, i.e., all of them are caused by disorder of immune system regulation. Chronic autoimmune thyroidism (Thyreoiditis lymphocytaria Hashimoto, HT), as well as immunogenic hyperthyroidism (Morbus Graves Basedow, MGB) are f

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Kupnicka, Patrycja, Małgorzata Król, Justyna Żychowska, et al. "GLP-1 Receptor Agonists: A Promising Therapy for Modern Lifestyle Diseases with Unforeseen Challenges." Pharmaceuticals 17, no. 11 (2024): 1470. http://dx.doi.org/10.3390/ph17111470.

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Modern lifestyle diseases remain a persistent challenge in healthcare. Currently, about 422 million people worldwide are affected by diabetes, while 1 in 8 people are living with obesity. The development of glucagon-like peptide 1 receptor agonists (GLP-1RAs) has marked a significant milestone in treating these conditions. Interest in GLP-1RAs has grown due to evidence that, beyond their established role in diabetes management, these drugs influence other metabolic disorders. This is attributed to the fact that GLP-1 receptors are found in various healthy human tissues. However, a potential ca

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Bharthi, Vandana, N. Kavya, M. N. Shubhashree, and Sulochana Bhat. "Herbal approach to management of thyroid disease - a review." Journal of Ayurvedic and Herbal Medicine 3, no. 1 (2017): 48–52. http://dx.doi.org/10.31254/jahm.2017.3109.

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Endocrine disorders are common in India of which the thyroid disorders represent a major subset. Thyroid dysfunction prevalence is rising at an alarming rate in Indian population. Hypothyroidism and hyperthyroidism constitute the maximum percentage of thyroid diseases in India. Hormone replacement therapy has been a standard approach to thyroid dysfunction. However, herbal approach to treatment of thyroid dysfunction is gaining popularity as it is said to be equally effective, safe and devoid of any side effects. Ayurvedic system of medicine has been very effective in maintenance and treatment

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Pratita, Winra, Karina Sugih Arto, and Nindia Sugih Arto. "Efficacy of Vitamin-D Supplement on Thyroid Profile in Children with Graves’ Disease." Open Access Macedonian Journal of Medical Sciences 8, B (2020): 798–801. http://dx.doi.org/10.3889/oamjms.2020.4790.

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BACKGROUND: Many studies have shown low Vitamin-D level as a risk factor for autoimmune diseases, especially multiple sclerosis and thyroid disease. Graves’ disease (GD) is an autoimmune disease caused by autoantibodies that stimulate thyroid-stimulating hormone (TSH) receptors by increasing thyroid hormone synthesis and secretion. Several studies report that many patients with autoimmune thyroid disease including GD have low Vitamin-D status. AIM: The objective of the study was to evaluate the effect of Vitamin-D supplement on GD patients on improvement in thyroid hormone levels.

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Gerasimov, G. A. "Thyroxine treatment of patients with thyroid diseases, foreign experience and its use in Russia (lecture)." Problems of Endocrinology 42, no. 1 (1996): 30–33. http://dx.doi.org/10.14341/probl11919.

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Thyroxine is one of the 13 most commonly prescribed drugs in the United States. Thyroxine is even more frequently prescribed to patients in several countries of Western Europe, where, due to iodine deficiency, there is a high prevalence of thyroid diseases. Indication for the use of thyroxine is either conventional replacement therapy in patients with hypothyroidism, or blocking the secretion of thyroid stimulating hormone (TSH) in patients with nodular goiter or after surgery for thyroid cancer. Hypothyroidism is a common disease: according to foreign authors, from 1.5 to 2% of women and abou

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М., С. Черенько, and М. Черенько С. "MANAGEMENT OF THYROID DISORDERS DURING AND AFTER PREGNANCY." REPRODUCTIVE ENDOCRINOLOGY, no. 45 (February 28, 2019): 14–18. https://doi.org/10.18370/2309-4117.2019.45.14-18.

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The state of the art review of the recent recommendations of American Thyroid Association and Endocrine Society comprehensively elucidates the most important issues of management of pregnant women with thyroid disorders. Authors shown that not only pregnancy impact thyroid function and course of thyroid diseases, but also functional thyroid changes can seriously affect mother and fetus. Thyroid stimulating hormone levels are significantly reduced by 0.1–0.4 mIU/ml for the lower limit of norm and by 1.0 mIU/ml for the upper in I trimester of pregnancy under the influence of placental chor

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Sheremeta, Marina S., Maria O. Korchagina, Ekaterina D. Pesheva, and Valentin V. Fadeev. "Radioactive iodine in the treatment of Graves' disease: history and modern concept of radionuclide therapy." Terapevticheskii arkhiv 94, no. 10 (2022): 1211–15. http://dx.doi.org/10.26442/00403660.2022.10.201887.

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Radioactive iodine 131I is a theranostic isotope used both for diagnosis and therapy of benign thyroid diseases and thyroid cancer for 85 years. The formation of nuclear medicine is closely linked with the use of 131I. The history of radioiodine therapy began in 1941, when endocrinologist Saul Hertz for the first time used 131I to treat patients with Graves' disease. Since 1946 radioactive iodine 131I became widely available, and its effectiveness became public knowledge after reports on thyrotoxicosis treatment published in the Journal of the American Medical Association by multidisciplinary

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Griroriev, Sergey, Elizaveta Bushueva, Anastasia Kozmenko, Maksim Gainetdinov, and Danila Zornikov. "RESULTS OF THE USE OF A DIRECTED BIOCORRECTION DRUG AND A DRUG CONTAINING LACTOFERRIN IN THE COMPLEX TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS IN PATIENTS WITH PRIMARY HYPOTHYROIDISM." Actual problems in dentistry 19, no. 4 (2024): 63–68. http://dx.doi.org/10.18481/2077-7566-2023-19-4-63-68.

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Subject In the traditional complex treatment of inflammatory periodontal diseases, antibacterial, antiseptic and anti-inflammatory agents are of paramount importance. These products allow you to obtain not only a positive clinical result, but can also manifest their negative properties, having an ambiguous effect on the microbiome of the oral cavity and periodontal tissue. The use of targeted biocorrection drugs and immunocorrectors has a significant local anti-inflammatory effect with minimal side effects. Their use in the complex treatment of chronic generalized periodontitis has not been st

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ZIMA, DMITRY V., EVGENIA YU ZYABLITSKAYA, ELENA P. GOLUBINSKAYA, et al. "IMPACT OF THE COVID-19 PANDEMIC ON THYROID SURGERY: A RETROSPECTIVE STUDY." Bulletin of Contemporary Clinical Medicine 16, no. 1 (2023): 28–33. http://dx.doi.org/10.20969/vskm.2023.16(1).28-33.

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Introduction. The COVID-19 pandemic has affected the pathomorphism of many diseases due to the pathophysiological impact of the infectious process and its drug therapy, and sometimes due to changes in the organization of medical care. During the pandemic, the number of patients with thyroid nodules has increased. Aim. To analyze the impact of the COVID-19 pandemic in Crimea on the surgical aspects of thyroid diseases. Material and methods. A study was made of the impact of the COVID-19 pandemic in Crimea on the surgical aspects of thyroid diseases. Statistical work was carried out with the dat

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Koch, G., V. Gotta, C. Ollagnier, et al. "O29 Pharmacometric modelling of free thyroxine dynamics after initiation of antithyroid drug treatment in children with Graves’ disease: a tool for personalized drug dosing in children." Archives of Disease in Childhood 104, no. 6 (2019): e13.1-e13. http://dx.doi.org/10.1136/archdischild-2019-esdppp.29.

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BackgroundThyroid hormones are essential for normal growth and puberty in children and adolescents. Graves’ disease (GD) is a rare autoimmune disorder associated with thyroid hormone over-production and occurs in 0.5–2:100’000 children (mostly females) in Europe. In contrast to adults, first line treatment of GD is long-term antithyroid drug (ATD) therapy, and radioiodine ablation is usually being reserved for patients after puberty. However, treatment of acquired hyperthyroidism with ATD is difficult since 1) paediatric patients differ considerable in age, weight and diseases severity and 2)

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Davitadze, Meri Z. "Autoimmune thyroiditis due to treatment with beta interferon-1b for Multiple sclerosis." Problems of Endocrinology 62, no. 5 (2016): 81–82. http://dx.doi.org/10.14341/probl201662581-82.

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Introduction. Since introduction of IFN-β1b for treatment of multiple sclerosis (MS), it was identified that beta interferon-1b can induce multiple alterations in thyroid function; though thyroid dysfunction is generally subclinical and often transient. The frequency of biological thyroid dysfunction has been studied in patients treated with IFN-β1b and was evaluated between 8.3 and 33%. On the other hand, autoimmune thyroid disease, as well as other autoimmune diseases, can occur in MS patients not receiving interferon-β therapy. It is unclear whether the occurrence of these diseases is incre

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Burch, H. B., B. L. Solomon, D. S. Cooper, P. Ferguson, N. Walpert, and R. Howard. "The Effect of Antithyroid Drug Pretreatment on Acute Changes in Thyroid Hormone Levels after 131I Ablation for Graves’ Disease1." Journal of Clinical Endocrinology & Metabolism 86, no. 7 (2001): 3016–21. http://dx.doi.org/10.1210/jcem.86.7.7639.

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Acute changes in thyroid hormone levels before and after radioiodine therapy for Graves’ disease were compared in 42 patients randomized to receive either antithyroid drug pretreatment or no pretreatment. Five patients (11.9%), including 3 in the pretreatment arm and 2 in the no pretreatment arm experienced a late exacerbation of thyrotoxicosis after radioiodine therapy. The majority (19 of 21, 90.5%) of pretreated patients experienced a transient increase in free T4 and free T3 after discontinuation of antithyroid drugs, with little further elevation after radioiodine therapy. After stopping

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Shpakov, A. O. "Pharmacological approaches for correction of thyroid dysfunctions in diabetes mellitus." Biomeditsinskaya Khimiya 63, no. 3 (2017): 219–31. http://dx.doi.org/10.18097/pbmc20176303219.

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Thyroid diseases are closely associated with the development of types 1 and 2 diabetes mellitus (DM), and as a consequence, the development of effective approaches for their treatment is one of the urgent problems of endocrinology. Traditionally, thyroid hormones (TH) are used to correct functions of the thyroid system. However, they are characterized by many side effects, such as their negative effect on the cardiovascular system as well as the ability of TH to enhance insulin resistance and to disturb insulin-producing function of pancreas, exacerbating thereby diabetic pathology. Therefore,

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Li, Zhenshengnan, Jia Wei, Bowen Chen, et al. "The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma." Molecules 28, no. 9 (2023): 3705. http://dx.doi.org/10.3390/molecules28093705.

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Matrix metalloproteinase-9 (MMP-9), one of the most investigated and studied biomarkers of the MMPs family, is a zinc-dependent proteolytic metalloenzyme whose primary function is degrading the extracellular matrix (ECM). It has been proved that MMP-9 expression elevates in multiple pathological conditions, including thyroid carcinoma. MMP-9 has a detectable higher level in malignant or metastatic thyroid tumor tissues than in normal or benign tissues and acts as an additional marker to distinguish different tumor stages because of its close correlations with clinical features, such as lymph n

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Obołończyk, Łukasz, Małgorzata Siekierska-Hellmann, Piotr Wiśniewski, et al. "Epidemiology, risk factors and prognosis of Interferon alpha induced thyroid disorders. A Prospective Clinical Study." Postępy Higieny i Medycyny Doświadczalnej 71 (September 25, 2017): 0. http://dx.doi.org/10.5604/01.3001.0010.4782.

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Introduction: Hepatitis C virus (HCV) infection is a worldwide problem and hepatitis, which is its natural unfavourable course, is still a challenge for hepatologist. At present, standards of treatment are changing from combined therapy with interferon alpha (IFN-α) and ribavirin to new antiviral drugs. The current classification divides interferon induced thyroid diseases (IITD) into two groups: autoimmune (Hashimoto disease, Graves disease, positive antithyroid autoantibodies in euthyroid patients) and non-autoimmune (destructive thyroiditis, non-autoimmune hypothyroidism). A common complica

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