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1

Rajendram, Rathie, Peter N. Taylor, Victoria J. Wilson, et al. "Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 × 2 factorial, double-blind, randomised controlled trial." Lancet Diabetes & Endocrinology 6, no. 4 (2018): 299–309. http://dx.doi.org/10.1016/s2213-8587(18)30021-4.

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2

M.D., T. R. Mizen. "Thyroid eye disease." Seminars in Ophthalmology 18, no. 4 (2003): 243–47. http://dx.doi.org/10.1080/08820530390895253.

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3

Hsu, H. J., C. K. Hsu, T. S. Chen, and C. H. Hsu. "Thyroid eye disease." QJM 109, no. 1 (2015): 67–68. http://dx.doi.org/10.1093/qjmed/hcv165.

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4

Bhatti, M. Tariq, and Jonathan J. Dutton. "Thyroid Eye Disease." Journal of Neuro-Ophthalmology 34, no. 2 (2014): 186–97. http://dx.doi.org/10.1097/wno.0000000000000128.

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5

Bhatti, M. Tariq, and Jonathan J. Dutton. "Thyroid Eye Disease." Journal of Neuro-Ophthalmology 34, no. 4 (2014): 426–27. http://dx.doi.org/10.1097/wno.0000000000000169.

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6

Stiebel-Kalish, Hadas, and Eyal Robenshtok. "Thyroid Eye Disease." Journal of Neuro-Ophthalmology 34, no. 4 (2014): 425–26. http://dx.doi.org/10.1097/wno.0000000000000187.

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7

Sergott, Robert C. "Thyroid eye disease." Current Opinion in Ophthalmology 1, no. 2 (1990): 187–89. http://dx.doi.org/10.1097/00055735-199001020-00019.

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8

Sergott, Robert C. "Thyroid eye disease." Current Opinion in Ophthalmology 1, no. 2 (1990): 187–89. http://dx.doi.org/10.1097/00055735-199004000-00019.

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9

Li, Zhen, Dean M. Cestari, and Elizabeth Fortin. "Thyroid eye disease." Current Opinion in Ophthalmology 29, no. 6 (2018): 528–34. http://dx.doi.org/10.1097/icu.0000000000000529.

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10

Belliveau, M. J., and D. R. Jordan. "Thyroid eye disease." Canadian Medical Association Journal 185, no. 9 (2013): 797. http://dx.doi.org/10.1503/cmaj.121815.

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11

Munro, D. "Thyroid eye disease." BMJ 306, no. 6881 (1993): 805–6. http://dx.doi.org/10.1136/bmj.306.6881.805.

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12

Modi, Neil C., Jennifer James, and Tamsin Sleep. "Thyroid Eye Disease." Journal of Perioperative Practice 19, no. 9 (2009): 282–86. http://dx.doi.org/10.1177/175045890901900902.

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Introduction Thyroid eye disease (TED), also known as Graves opthalmopathy is the most common orbital disease and affects 25–50% of patients with Graves' disease (Kuryan et al 2008). Most patients are only mildly affected, suffering ocular irritation with redness and watering, ‘staring eyes' due to retraction of the eyelids, exophthalmos (protrusion of the eyeballs) and periorbital swelling (Figure 1). A minority of patients (around 28%) will develop ocular motility problems, leading to diplopia (double vision), exposure/damage to the cornea and optic neuropathy (Kumar & Clarke 2002, Forbe
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13

Victores, Andrew J., and Masayoshi Takashima. "Thyroid Eye Disease." International Ophthalmology Clinics 56, no. 1 (2016): 69–79. http://dx.doi.org/10.1097/iio.0000000000000101.

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14

Char, D. H. "Thyroid eye disease." British Journal of Ophthalmology 80, no. 10 (1996): 922–26. http://dx.doi.org/10.1136/bjo.80.10.922.

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15

WEETMAN, A. P. "Thyroid eye disease." British Journal of Ophthalmology 82, no. 8 (1998): 976c. http://dx.doi.org/10.1136/bjo.82.8.976c.

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16

Waller, Robert R. "Thyroid Eye Disease." Mayo Clinic Proceedings 61, no. 2 (1986): 160. http://dx.doi.org/10.1016/s0025-6196(12)65210-0.

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17

Cockerham, Kimberly P., and Stephanie S. Chan. "Thyroid Eye Disease." Neurologic Clinics 28, no. 3 (2010): 729–55. http://dx.doi.org/10.1016/j.ncl.2010.03.010.

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18

Scott, Ingrid U., and R. Michael Siatkowski. "Thyroid Eye Disease." Seminars in Ophthalmology 14, no. 2 (1999): 52–61. http://dx.doi.org/10.3109/08820539909056064.

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19

Elston, John S. "Thyroid eye disease." Eye 4, no. 4 (1990): vii. http://dx.doi.org/10.1038/eye.1990.71.

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20

&NA;. "THYROID EYE DISEASE." Ophthalmic Plastic & Reconstructive Surgery 9, Supplement (1993): 27–30. http://dx.doi.org/10.1097/00002341-199301001-00012.

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21

Perros, P., C. Neoh, and J. Dickinson. "Thyroid eye disease." BMJ 338, mar06 1 (2009): b560. http://dx.doi.org/10.1136/bmj.b560.

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22

Rashad, Ramy, Raquel Pinto, Emily Li, Mahsa Sohrab, and Alberto G. Distefano. "Thyroid Eye Disease." Life 12, no. 12 (2022): 2084. http://dx.doi.org/10.3390/life12122084.

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Thyroid eye disease (TED), an autoimmune inflammatory disorder of the orbit, presents with a potential array of clinical sequelae. The pathophysiology behind TED has been partially characterized in the literature. There remain certain elusive mechanisms welcoming of research advances. Disease presentation can vary, but those that follow a characteristic course start mild and increase in severity before plateauing into an inactive phase. Diagnosis and evaluation include careful physical examination, targeted laboratory work up, appropriate imaging studies, and tailored treatment regimens. Speci
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23

Cornblath, Wayne Todd. "Thyroid eye disease." Current Treatment Options in Neurology 2, no. 5 (2000): 401–5. http://dx.doi.org/10.1007/s11940-000-0038-6.

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24

Borodic, G. "Thyroid Eye Disease." Archives of Ophthalmology 104, no. 8 (1986): 1142–43. http://dx.doi.org/10.1001/archopht.1986.01050200048044.

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25

Khwarg, Sang In. "Thyroid Eye Disease." Archives of Ophthalmology 117, no. 1 (1999): 143. http://dx.doi.org/10.1001/archopht.117.1.143.

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26

Xin, Xiangyang, Lili Gao, Xinping Kong, Chengkun An, and Bin Shen. "Thyroid-associated eye disease." Discussion of Clinical Cases 2, no. 2 (2015): 34. http://dx.doi.org/10.14725/dcc.v2n2p34.

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27

Patel, Payal, Joyce Khandji, and Michael Kazim. "Recurrent Thyroid Eye Disease." Ophthalmic Plastic and Reconstructive Surgery 31, no. 6 (2015): 445–48. http://dx.doi.org/10.1097/iop.0000000000000371.

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28

Ugradar, Shoaib, and Daniel B. Rootman. "Noninflammatory Thyroid Eye Disease." Ophthalmic Plastic and Reconstructive Surgery 35, no. 5 (2019): 461–64. http://dx.doi.org/10.1097/iop.0000000000001087.

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29

Chua, Michael R., Lauren A. Tomlinson, Gil Binenbaum, and William R. Katowitz. "Pediatric Thyroid Eye Disease." Ophthalmic Plastic and Reconstructive Surgery 34 (2018): S52—S55. http://dx.doi.org/10.1097/iop.0000000000001137.

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30

Lee, Miss Vickie, and Kitt Dokal. "CPD: Thyroid eye disease." Optician 270, no. 6973 (2024): 20–26. https://doi.org/10.12968/opti.2024.270.6973.20.

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31

Heufelder, Armin E., and Werner Joba. "Thyroid-associated eye disease." Strabismus 8, no. 2 (2000): 101–11. http://dx.doi.org/10.1076/0927-3972(200006)821-2ft101.

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32

Heufelder, Armin E., and Werner Joba. "Thyroid-associated eye disease." Strabismus 8, no. 2 (2000): 101–11. http://dx.doi.org/10.1076/0927-3972(200006)8:2;1-2;ft101.

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33

Freeman, AnthonyG. "Thyroid-associated eye disease." Lancet 338, no. 8764 (1991): 454–55. http://dx.doi.org/10.1016/0140-6736(91)91085-9.

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34

Penne, R. B. "Recurrent Thyroid Eye Disease." Yearbook of Ophthalmology 2016 (2016): 206–7. https://doi.org/10.1016/j.yoph.2016.02.165.

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35

Dolman, Peter J., and Magdalena A. Wirth. "Glucocorticoids for Thyroid Eye Disease." International Ophthalmology Clinics 61, no. 2 (2021): 63–78. http://dx.doi.org/10.1097/iio.0000000000000357.

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36

Volpe, Nicholas J. "THYROID EYE DISEASE (3RD EDITION)." Ophthalmic Surgery, Lasers and Imaging Retina 31, no. 1 (2000): 84. http://dx.doi.org/10.3928/1542-8877-20000101-20.

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37

Park, Jung Yul. "Glaucoma and Thyroid Eye Disease." Journal of the Korean Glaucoma Society 9, no. 1 (2020): 40. http://dx.doi.org/10.36299/jkgs.2020.9.1.40.

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38

Leibovitch, Igal, Hirohiko Kakizaki, and Dinesh Selva. "Steroids in thyroid eye disease." Clinical & Experimental Ophthalmology 38, no. 7 (2010): 657–58. http://dx.doi.org/10.1111/j.1442-9071.2010.02384.x.

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39

Kahaly, George J. "Immunotherapies for thyroid eye disease." Current Opinion in Endocrinology & Diabetes and Obesity 26, no. 5 (2019): 250–55. http://dx.doi.org/10.1097/med.0000000000000493.

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40

Silkiss, Rona Z., Alice Reier, Morton Coleman, and Simeon A. Lauer. "Rituximab for Thyroid Eye Disease." Ophthalmic Plastic & Reconstructive Surgery 26, no. 5 (2010): 310–14. http://dx.doi.org/10.1097/iop.0b013e3181c4dfde.

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41

Weiler, Danielle L. "Thyroid eye disease: a review." Clinical and Experimental Optometry 100, no. 1 (2016): 20–25. http://dx.doi.org/10.1111/cxo.12472.

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42

Kuriyan, Ajay E., Richard P. Phipps, and Steven E. Feldon. "The eye and thyroid disease." Current Opinion in Ophthalmology 19, no. 6 (2008): 499–506. http://dx.doi.org/10.1097/icu.0b013e3283131557.

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43

Wu, Chris Y., Victor M. Elner, and Alon Kahana. "Severe Pediatric Thyroid Eye Disease." Ophthalmic Plastic and Reconstructive Surgery 33 (2017): S186—S188. http://dx.doi.org/10.1097/iop.0000000000000585.

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44

Rubinstein, Tal J., Shirin Hamed-Azzam, and Jimmy M. Uddin. "Re: “Noninflammatory Thyroid Eye Disease”." Ophthalmic Plastic and Reconstructive Surgery 36, no. 1 (2020): 98. http://dx.doi.org/10.1097/iop.0000000000001550.

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45

Hwang, Christopher J., and Kian Eftekhari. "Teprotumumab for Thyroid Eye Disease." International Ophthalmology Clinics 60, no. 2 (2020): 47–55. http://dx.doi.org/10.1097/iio.0000000000000307.

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46

Penne, R. B. "Rituximab for thyroid eye disease." Yearbook of Ophthalmology 2011 (January 2011): 147–48. http://dx.doi.org/10.1016/j.yoph.2011.06.012.

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47

Oh, Sang-Rog, Ayelet Priel, Leah Levi, David B. Granet, Bobby S. Korn, and Don O. Kikkawa. "Rituximab for Thyroid Eye Disease." Ophthalmology 118, no. 4 (2011): 792. http://dx.doi.org/10.1016/j.ophtha.2011.01.012.

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48

Draman, Mohd Shazli, and Marian Ludgate. "Thyroid eye disease- an update." Expert Review of Ophthalmology 11, no. 4 (2016): 273–84. http://dx.doi.org/10.1080/17469899.2016.1202113.

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49

KAHALY, GEORGE, GREGOR FÖRSTER, and CHRISTIANE HANSEN. "Glycosaminoglycans in Thyroid Eye Disease." Thyroid 8, no. 5 (1998): 429–32. http://dx.doi.org/10.1089/thy.1998.8.429.

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50

Weinstein, Joel. "Thyroid Eye Disease, ed. 2." American Journal of Ophthalmology 111, no. 1 (1991): 122. http://dx.doi.org/10.1016/s0002-9394(14)76923-5.

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