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Journal articles on the topic 'Thyroid gland diseases - drug therapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Melnichenko, Galina A., Anastasiya A. Glibka, and Olga Y. Demicheva. "Thyroid dysfunction following immune reconstitution therapy." Clinical and experimental thyroidology 15, no. 4 (2020): 156–61. http://dx.doi.org/10.14341/ket12225.

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Medication effects on the immune system often lead to the development of adverse events such as autoimmune diseases. The thyroid gland is organ whose embryonic development features are predisposed spontaneous and induced lesions with various autoimmune effects. Cytokinin-induced thyroiditis (in 5070% of cases proceeds as a destructive thyroiditis), thyroid dysfunction following immune checkpoint inhibitors (using the combined treatment CTLA-4 + PD-1/PD-L1 leads to an increase hypothyroidism rates up to 20%). Some researchers presume that can develop thyroid dysfunction following treatmen

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2

Berihanova, RR, and IA Minenko. "Interrelation of non-drug correction of menopausal disorders and functioning of the pituitary-thyroid system in women with metabolic syndrome." TARGETED ONCOTHERAPY, no. 2 (April 11, 2019): 81–88. http://dx.doi.org/10.24075/brsmu.2019.023.

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In perimenopausal women, the frequency of thyroid diseases and metabolic syndrome (MS) increases. In this work, the effect of non-drug correction programs for menopausal disorders on the structural and functional state of the thyroid gland in patients with MS was evaluated. For that, five groups of women (330 people total) aged 45–50 years with climacteric syndrome (CS) against the background of MS were examined. For the index group and the experimental groups the following was used: basic treatment, exercise therapy, drinking balneotherapy, additional oral intake of multivitamins and minerals

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3

Kryukov, E. V., N. P. Potekhin, A. N. Fursov, et al. "Algorithm of management of patients treated with amiodarone depending on thyroid functional state." Clinical Medicine (Russian Journal) 95, no. 10 (2017): 901–5. http://dx.doi.org/10.18821/0023-2149-2017-95-10-901-905.

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Cardiac arrhythmias are common symptoms of various cardiovascular diseases. Currently, amiodarone is considered to be one of the most efficient and safe antiarrhythmic drugs. Long-term use of amiodarone having the chemical structure similar to that of thyroxine can cause disturbances in the functional state of the thyroid gland. 32 (6.9 percent) of the 462 patients who used the drug for more than six months developed amiodarone-associated thyrotoxicosis and 11 (2,5%) one amiodarone-associated hypothyroidism. Most patients with hyperthyroidism, 22 (68,8%), did not have any structural pathology

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Fabito, Elmer F., Mary Jane Tipayno-Lubos, and Felixberto D. Ayahao. "Tuberculosis of the Thyroid." Philippine Journal of Otolaryngology-Head and Neck Surgery 32, no. 1 (2017): 47–50. http://dx.doi.org/10.32412/pjohns.v32i1.189.

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Objectives: To present a case of thyroid tuberculosis and to discuss its clinical presentation, differential diagnoses and management. Methods: Design: Case Report Setting: Tertiary Government Hospital Patient: One Results: A 55-year-old farmer presented with an 8-month progressively enlarging anterior neck mass, and fine needle aspiration biopsy yielded grossly turbid straw-colored aspirate admixed with blood with microscopy showing scattered inflammatory cells and macrophages set against a colloid background. After total thyroidectomy, hispathology revealed pare

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5

Verbovoy, A. F., N. I. Verbovaya, and Yu A. Dolgikh. "Symbiosis of cardiology and endocrinology." Meditsinskiy sovet = Medical Council, no. 14 (October 15, 2020): 80–89. http://dx.doi.org/10.21518/2079-701x-2020-14-80-89.

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In medical practice, there are often patients who have several diseases at once, both pathogenetically related to each other and not related. The article discusses endocrine diseases in which there are manifestations from the cardiovascular system - disorders of carbohydrate metabolism, pathology of the thyroid gland, adrenal glands and acromegaly. These diseases reduce the quality of life of patients and increase the risks of cardiovascular complications. The article also discusses the features of cardiovascular manifestations in these diseases and indications for differential diagnosis. Type

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6

Davitadze, Meri Z. "Autoimmune thyroiditis due to treatment with beta interferon-1b for Multiple sclerosis." Problems of Endocrinology 62, no. 5 (2016): 81–82. http://dx.doi.org/10.14341/probl201662581-82.

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Introduction. Since introduction of IFN-β1b for treatment of multiple sclerosis (MS), it was identified that beta interferon-1b can induce multiple alterations in thyroid function; though thyroid dysfunction is generally subclinical and often transient. The frequency of biological thyroid dysfunction has been studied in patients treated with IFN-β1b and was evaluated between 8.3 and 33%. On the other hand, autoimmune thyroid disease, as well as other autoimmune diseases, can occur in MS patients not receiving interferon-β therapy. It is unclear whether the occurrence of these diseases is incre

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7

Markovic, Ljiljana, Violeta Mihailovic-Vucinic, and Jelena Aritonovic. "Hormones of thyroid gland in sera of rats treated with different dose of concentrated potassium iodine solutions." Srpski arhiv za celokupno lekarstvo 138, no. 5-6 (2010): 323–27. http://dx.doi.org/10.2298/sarh1006323m.

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Introduction Potassium iodine (KI) is used as a drug therapy for treating numerous diseases such as small-vessel vasculitis, erythema nodosum, vasculitis nodularis, Sweet's syndrome, tuberculosis and granulomatosis, and for iodized salt. At the same time, KI can be harmful. Iodine intake may increase the frequency of thyroiditis in humans, and may induce the occurrence of experimental thyroiditis (ET) in animals. Investigations on an experimental model for the examination of thyroiditis in Wistar rats have clearly showed morphological changes in the rat thyroid evoked by KI administration. Obj

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8

Biryukova, E. V., D. V. Kileynikov, and I. V. Solovyeva. "Hypothyroidism: current state of the problem." Meditsinskiy sovet = Medical Council, no. 7 (May 29, 2020): 96–107. http://dx.doi.org/10.21518/2079-701x-2020-7-96-107.

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The article presents the issues of epidemiology, classification, and clinic of hypothyroidism. The frequency of hypothyroidism increases significantly with age. The most common form is primary hypothyroidism, caused by a pathological process in the thyroid gland itself. Secondary hypothyroidism or tertiary hypothyroidism is caused by insufficient secretion of thyroid- stimulating hormone (TSH), or thyrotropin-releasing hormone. The article deals with the main causes of primary and secondary hypothyroidism. The most common cause of primary hypothyroidism is autoimmune thyroiditis, which can dev

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9

Malyshenko, Yu A., O. D. Rymar, M. V. Ivanova, L. V. Shcherbakova, and S. F. Zhinchyk. "THE CHARACTERISTICS OF BLOOD LIPIDS OF MENOPAUSAL WOMEN WITH THE COMPENSATED HYPOTHYROIDISM WHICH RESULTS FROM AUTOIMMUNE THYROIDITIS." Bulletin of Siberian Medicine 13, no. 2 (2014): 14–20. http://dx.doi.org/10.20538/1682-0363-2014-2-14-20.

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Purpose: to study the lipid profile, including of non-high-density lipoproteins cholesterol (non-HDL-C), in postmenopausal women with compensated hypothyroidism. The causes of hypothyroidism included Hashimoto thyroiditis.45 women with hypothyroidism participated in the study (mean ± sd, age (57.4 ± 7.7) years, disease duration (8.0 ± 6.4) years, the duration of postmenopause (6.4 ± 3.5) years). The mean dose of L-T4 (84.3 ± 28.5) μg/d. The control group – 85 women (mean ± sd, age (58.4 ± 5.4) years) no abnormalities of the thyroid gland, as well as other chronic diseases, which could have an

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10

Ibrahim, Amira, and Victoria Loseva. "A Case of Thyroid Eye Disease Revealed During Secondary Adrenal Insufficiency." Journal of the Endocrine Society 5, Supplement_1 (2021): A910. http://dx.doi.org/10.1210/jendso/bvab048.1858.

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Abstract Introduction: Thyroid eye disease (TED) or Graves’ orbitopathy (GO) is an autoimmune disease of the retro-orbital tissues. GO is mostly associated with hyperthyroidism in 90% of patients; however, it may coexist with hypothyroid conditions in 5% of cases. Clinical Case: A 56-year-old male with a past medical history of autoimmune diseases including hypothyroidism and Ulcerative Colitis on chronic steroid therapy presented to the emergency department with nausea, fatigue, weight loss, and muscle weakness. The patient stated that his glucocorticoids were abruptly discontinued a month pr

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Pyrohova, V. I., S. O. Shurpyak, Yu R. Fayta, M. Y. Malachinska, and N. M. Kuz. "Comparative study of the efficacy of topical therapy of mixed vaginitis associated with cervicitis by combined medications." HEALTH OF WOMAN, no. 6(132) (July 30, 2018): 42–49. http://dx.doi.org/10.15574/hw.2018.132.42.

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The objective: to increase the effectiveness of local therapy for recurrent nonspecific vaginitis associated with cervicitis in women of reproductive age on the basis of a comparative evaluation of combined drugs Terzhinan and Neo Penotran Forte. Materials and methods. A prospective, open comparative study included 56 women aged 27.5±2.8 years with recurrent nonspecific vaginitis and cervicitis who were randomized to the main group and comparison group. Patients of the main group (n=28) received the drug Terzhinan® (1 vaginal tablet in the evening, before bed, for 10 days). The comparison grou

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Carneiro, Luís Eduardo, Ana Carolina Vanz, and Heloísa Helena de Alcantara Barcellos. "Previous Treatment with Trilostane and Levotiroxin in Subdosis Difficult the Diagnosis of Canine Hypothyroidism." Acta Scientiae Veterinariae 46 (June 22, 2018): 5. http://dx.doi.org/10.22456/1679-9216.86897.

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Background: hypothyroidism is a disease of clinical importance that causes multisystem disorders, which can be confused with other endocrinopathies. Rapid and accurate diagnosis is necessary in order to avoid worsening of the clinical manifestation. The use of drugs in a wrong way can directly imply the difficulty of the diagnostic approach, since they may causechanges in the biochemical profiles, which are of great importance as markers in diseases of animals with low thyroid function.Case: The case reports a German Spitz male, one year old and six months old, neutered, who presented bilatera

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13

Lapcevic, Mirjana. "Autoimmune thyroid disease and associated diseases." Srpski arhiv za celokupno lekarstvo 133, Suppl. 1 (2005): 84–87. http://dx.doi.org/10.2298/sarh05s1084l.

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Autoimmune thyroid disease (ATD) is a multifactorial, genetic disease. It is the sequelae of the impaired immunoregulation, tolerance and poor recognition of one?s own proteins, oligopolysaccharides and polypeptides, due to development of somatic lymphocyte mutations. It is manifested by different clinical and morphological entities, inter-related by etiopathogenetic association, i.e., all of them are caused by disorder of immune system regulation. Chronic autoimmune thyroidism (Thyreoiditis lymphocytaria Hashimoto, HT), as well as immunogenic hyperthyroidism (Morbus Graves Basedow, MGB) are f

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Marina, Djordje, and Silvija Sajic. "Lingual thyroid." Srpski arhiv za celokupno lekarstvo 135, no. 3-4 (2007): 201–3. http://dx.doi.org/10.2298/sarh0704201m.

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Lingual thyroid is a rare congenital malformation that occurs more frequently in the female population. It occurs because of the error in transcriptional factors, the key for the normal differentiation of thyrocyte, so the thyroid gland tissue does not descend normally down the thyroglossal duct to the final position in the neck. Due to that, it can entirely or partially remain at the base of the tongue. This is the most frequent localization of the ectopic tissue while it can remain in the sublingual, suprahyoid and infrahyoid area as well. This disease can be diagnosed in the asymptomatic ph

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15

Raruenrom, Yutapong. "Success Rate of Radioactive Iodine Therapy in Graves’ Disease Using Dose Corrected for Thyroid Gland Size." Siriraj Medical Journal 72, no. 2 (2021): 108–13. http://dx.doi.org/10.33192/smj.2021.15.

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Objective: Dose corrected for thyroid gland size is one of the methods used to determine I-131 activity for patients with Graves’ disease. This study aimed to find the success rate of this method and the predictors for successful I-131 treatment. Methods: This retrospective descriptive study conducted was in patients with Graves’ disease who received the first dose of radioactive iodine (RAI) therapy. Patients received a fixed RAI dose of either 10, 15, 20, 25, or 30 mCi for corresponding thyroid gland size of ≤ 50, 51-100, 101-150, 151-200, and >200 grams, respectively. The treatment outco

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16

Angerpointner, Thomas A. "Experience with the operative therapy of diseases of the thyroid gland in childhood." Journal of Pediatric Surgery 24, no. 5 (1989): 500. http://dx.doi.org/10.1016/s0022-3468(89)80416-6.

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17

Oe, Hideaki, and Ryuichiro Doi. "Poster Presentation on Adrenal, Pituitary, and Other Endocrine Glands, Parathyroid Gland, Thyroid Gland." World Journal of Endocrine Surgery 8, no. 1 (2016): 55–127. http://dx.doi.org/10.5005/wjoes-8-1-55.

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ABSTRACT BACKGROUND AND AIMS Gastrointestinal and pancreatic neuroendocrine tumors (NET) are classified as low grade (G1), intermediate grade (G2), and high grade (G3) by mitotic rate and/or Ki-67 index. The basic treatment for neuroendocrine carcinoma (NEC, G3) with remote metastasis is platinum-based systemic chemotherapy. In contrast, for patients with NET G1 or G2 with remote metastasis, multidisciplinary treatment is necessary in order to prolong patients' survival and relieve symptoms. We report here a patient with pancreatic G1 gastrinoma and its multiple liver metastases. METHODS The p

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Horvat, Olga, Zdenko Tomic, Vesna Mijatovic, and Ana Sabo. "Drug utilization in treatment of thyroid disorders during pregnancy in Serbia." Medical review 69, no. 1-2 (2016): 11–15. http://dx.doi.org/10.2298/mpns1602011h.

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Introduction. Depleted uranium radiation and pollution with polychlorinated biphenyls resulting from bombings the territories of Serbia as well as the additional long-term stress may have affected the function of thyroid gland. The objective of this study was to determine the trend of drug utilization in the treatment of thyroid dysfunction during pregnancy in Novi Sad. Material and Methods. Women who had given birth at the Department of Gynecology in 1989, 1999, 2007 and 2011 were interviewed during a one-month period about thyroid diseases in the pregnancy as well as the drugs they had taken

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19

Auvinen, O., G. A. Baer, I. Nordback, and J. Saaristo. "Antifibrinolytic therapy for prevention of hemorrhage during surgery of the thyroid gland." Klinische Wochenschrift 65, no. 6 (1987): 253–55. http://dx.doi.org/10.1007/bf01773442.

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20

Çaksen, Hüseyin, Ahmet Tutuş, Selim Kurtoğlu, Figen Öztürk, Yüksel Okumuş, and Bekir Çoksevim. "Low Dose Ketoconazole Therapy and Thyroid Functions in Rats." Acta Medica (Hradec Kralove, Czech Republic) 45, no. 4 (2002): 177–79. http://dx.doi.org/10.14712/18059694.2019.77.

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To determine whether low dose ketoconazole (KTZ) has antithyroid action, we studied thyroid function tests in the 13 rats treated with KTZ (20 mg/kg twice daily) for thirty days. Serum triiodothyronine and thyroxine levels were decreased (P <0.05) and serum thyroid-stimulating hormone levels were mildly increased (P >0.05) at the end of treatment. Histopathological analysis of the thyroid glands demonstrated an increase in cylindrical cells in study group, but the epithelial cells were mainly cubical in control group. These findings showed that low dose KTZ had antithyroid effect in rats

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Paunkov, Ana, Dionysios V. Chartoumpekis, Panos G. Ziros, Niki Chondrogianni, Thomas W. Kensler, and Gerasimos P. Sykiotis. "Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway." Current Pharmaceutical Design 25, no. 16 (2019): 1828–46. http://dx.doi.org/10.2174/1381612825666190701165821.

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Background:Natural compounds with potential antioxidant properties have been used in the form of food supplements or extracts with the intent to prevent or treat various diseases. Many of these compounds can activate the cytoprotective Nrf2 pathway. Besides, some of them are known to impact the thyroid gland, often with potential side-effects, but in other instances, with potential utility in the treatment of thyroid disorders.Objective:In view of recent data regarding the multiple roles of Nrf2 in the thyroid, this review summarizes the current bibliography on natural compounds that can have

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Martino, E., L. Bartalena, S. Mariotti, et al. "Radioactive iodine thyroid uptake in patients with amiodarone-iodine-induced thyroid dysfunction." Acta Endocrinologica 119, no. 2 (1988): 167–73. http://dx.doi.org/10.1530/acta.0.1190167.

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Abstract. Amiodarone, an iodine-rich drug, represents at the present, at least in Europe, one of the most common sources of iodine-induced thyroid dysfunction. The drug may induce both hypothyroidism and thyrotoxicosis. In spite of the large iodine intake occurring during amiodarone therapy, 131I thyroid uptake is detectable in patients with amiodarone-iodine-induced hypothyroidism, irrespective of the presence or absence of underlying thyroid disease. In contrast, in patients with amiodarone-iodine-induced thyrotoxicosis, 131I thyroid uptake is normal or even elevated in those with co-existen

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Timofeeva, E. V., and O. Ya Leshchenko. "FEATURES OF THE FUNCTIONING OF THE THYROID GLAND IN HIV-INFECTED." Annals of the Russian academy of medical sciences 68, no. 10 (2013): 53–56. http://dx.doi.org/10.15690/vramn.v68i10.789.

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In the article the current literature, devoted to the peculiarities of functioning of the thyroid gland in patients with HIV infection, is analyzed. Based on the analysis of literature data bases demonstrated the structure of thyroid function disorders in HIV-infected, as well as the mechanisms of the pathogenesis of these disorders. In the structure of thyroid function is dominated by hypothyroidism, euthyroid pathological syndrome, Graves' disease, for which the opportunistic infections are triggers immune activation. It should be noted that the step of acquired immunodeficiency syndrome is

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Stojanovic, Dragos, Dragan Radovanovic, Zorica Caparevic, Mirjana Jakovljevic-Stojanovic, Djordje Lalosevic, and Predrag Stevanovic. "Ucestalost javljanja karcinoma u solitarnim nodusima stitaste zlezde." Acta chirurgica Iugoslavica 50, no. 3 (2003): 47–50. http://dx.doi.org/10.2298/aci0303047s.

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Find of malignances in solitary thyroid gland nodes represent an entity in itself in thyroid surgery and endocrinology because of frequency in occurrence and differential diagnosis of thyroid diseases. Similarities in clinical characteristics and differences in the histological structure and development of the disease, request quick and adequate application of all available diagnostic procedures in evaluation of disease. After all clinic methods of examination, surgery includes necessary range of extraction of tissue at benign changes while at malignant changes radical intervention on the glan

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Balabolkin, M. I. "III All-Russian Congress of Endocrinologists." Problems of Endocrinology 42, no. 6 (1996): 41–43. http://dx.doi.org/10.14341/probl12061.

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The III All-Russian Congress of Endocrinologists was held in Moscow from June 4 to 7, 1996. The scientific program of the congress included almost all sections of endocrinology: diabetes mellitus, diseases of the hypothalamic-pituitary system, diseases of the thyroid and parathyroid glands, pathology of the adrenal glands and gonads. A separate symposium at the congress was devoted to endocrine pathology as a consequence of radiation disasters. The first plenary lecture at the congress was dedicated to the late complications of diabetes, which was presented by the president of the Russian Acad

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Brien, James F., Sandra Jimmo, F. James Brennan, Sally E. Ford, and Paul W. Armstrong. "Distribution of amiodarone and its metabolite, desethylamiodarone, in human tissues." Canadian Journal of Physiology and Pharmacology 65, no. 3 (1987): 360–64. http://dx.doi.org/10.1139/y87-062.

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The distribution of the antiarrhythmic drug amiodarone and its principal lipophilic metabolite, desethylamiodarone, was determined in postmortem tissues of six patients who received amiodarone therapy (treatment period, 6–189 days; total dose, 4.8–127.0 g). Amiodarone concentration was highest in liver, lung, adipose tissue, and pancreas, followed by kidney, heart (left ventricle), and thyroid gland, and lowest in antemortem plasma. There was no measurable amiodarone in brain (<1.0 μg/g). Desethylamiodarone concentration was highest in liver and lung, followed by pancreas, adipose tissue, k

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Bonnema, Steen Joop, and Laszlo Hegedüs. "Radioiodine Therapy in Benign Thyroid Diseases: Effects, Side Effects, and Factors Affecting Therapeutic Outcome." Endocrine Reviews 33, no. 6 (2012): 920–80. http://dx.doi.org/10.1210/er.2012-1030.

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Radioiodine (131I) therapy of benign thyroid diseases was introduced 70 yr ago, and the patients treated since then are probably numbered in the millions. Fifty to 90% of hyperthyroid patients are cured within 1 yr after 131I therapy. With longer follow-up, permanent hypothyroidism seems inevitable in Graves' disease, whereas this risk is much lower when treating toxic nodular goiter. The side effect causing most concern is the potential induction of ophthalmopathy in predisposed individuals. The response to 131I therapy is to some extent related to the radiation dose. However, calculation of

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Riesco-Eizaguirre, Garcilaso, and Pilar Santisteban. "A perspective view of sodium iodide symporter research and its clinical implications." European Journal of Endocrinology 155, no. 4 (2006): 495–512. http://dx.doi.org/10.1530/eje.1.02257.

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The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active iodide transport into the thyroid gland and into several extrathyroidal tissues, in particular the lactating mammary gland. Cloning and molecular characterization of the NIS have allowed the investigation of its key role in thyroid physiology as well as its potential pathophysiological and therapeutic implications in benign and malignant thyroid diseases. Similarly, elucidating the mechanisms underlying the regulation of NIS in lactating mammary gland and breast cancer, in which more than 80% of case

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Ten, Yu V. I., A. A. Krasilnikov, Yuri V. Ten, and D. A. Yelkova. "PECULIARITIES OF SURGICAL TREATMENT OF THYROID GLAND IN CHILDREN." Russian Journal of Pediatric Surgery 22, no. 5 (2018): 254–57. http://dx.doi.org/10.18821/1560-9510-2018-22-5-254-257.

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The pediatric surgeon in his work has to face a wide variety of diseases related to narrow areas of medicine. Particular difficulties are caused by the diagnosis and treatment of thyroid gland formations (TGF). The number of such patients is steadily growing both in the Russian Federation and in the Altai Territory, due to iodine deficiency, radiological and environmental pollution and other possible causes. In the Children’s Surgery Clinic of the Altai State Medical University, 101 children aged from 5 to 17 years were treated in the period from 2000 to 2017 due to thyroid lesions. The study

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Radojkovic, Ivan, Jana Radojkovic, and Snezana Djurica. "Diagnosis of osteoporosis occurring in autoimmune thyroid gland disease." Srpski arhiv za celokupno lekarstvo 133, Suppl. 1 (2005): 40–45. http://dx.doi.org/10.2298/sarh05s1040r.

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Osteoporosis or porotic bone is a general, systemic bone disease, which is manifested by fracture as its consequence. The main characteristic of this disease is the loss of bone microarchitecture, bone mass reduction, and its increased fragility. The result, thereof, is susceptibility to fracture. Etiology of osteoporosis is polymorph. Its socio-medical importance is enormous, since there is one osteoporotic fracture every 20 sec. worldwide. Million and six hundred thousand osteoporotic fractures occur annualy throughout the world. Thyroid gland is susceptible to autoimmune reactions that lead

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Kech, N. R., O. Z. Hnateyko, and O. L. Lychkovska. "THE CLINICAL AND FUNCTIONAL STATE OF THE THYROID GLAND IN CHILDREN FROM ECOLOGICALLY UNFAVOURABLE AREAS IN THE DYNAMICS OF TREATMENT." Problems of Endocrine Pathology 69, no. 3 (2019): 14–21. http://dx.doi.org/10.21856/j-pep.2019.3.02.

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During the period from 2015 to 2017, 359 children between the ages of three and sixteen who originated from and still live in the ecologically unfavourable areas (EUA) of Ivano-Frankivsk region were examined by clinical, laboratory and instrumental means.The aim of the research is to prove the effectiveness of adequate therapy for thyroid ecodependent diseases treatment. The method of the research involves the general clinical and ultrasonic testing of the thyroid gland,as well as the study of its T3 and T4 hormones activity since the pa 3 and T4 hormones activity since the pathology of the th

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Toi, Mohan, and Praveen Prabhakar. "Thyroid Profile in Diabetic Patients in a Tertiary Care Centre at Alappuzha, Kerala, India." Journal of Evidence Based Medicine and Healthcare 8, no. 10 (2021): 517–21. http://dx.doi.org/10.18410/jebmh/2021/101.

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BACKGROUND Diabetes mellitus is the most common endocrine metabolic disease. Thyroid disorders are the second most common endocrine disorders, there is a high chance for an individual to have both diseases. Drugs for diabetes modify thyroid gland function, so these drug interactions have to be taken into account for treatment of diabetics with thyroid disorder. We wanted to study the profile of thyroid gland dysfunction in patients with type 2 diabetes mellitus. METHODS A cross sectional observational study was conducted among 230 subjects attending our tertiary care centre, meeting case defin

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Laurberg, Peter, Claire Bournaud, Jesper Karmisholt, and Jacques Orgiazzi. "Management of Graves' hyperthyroidism in pregnancy: focus on both maternal and foetal thyroid function, and caution against surgical thyroidectomy in pregnancy." European Journal of Endocrinology 160, no. 1 (2009): 1–8. http://dx.doi.org/10.1530/eje-08-0663.

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Graves' disease is a common autoimmune disorder in women in fertile ages. The hyperthyroidism is causedby generation of TSH-receptor activating antibodies. In pregnancy both the antibodies and the antithyroid medication given to the mother pass the placenta and affect the foetal thyroid gland. Thyroid function should be controlled not only in the mother with Graves' hyperthyroidism but also in her foetus.The review includes two cases illustrating some of the problems in managing Graves' disease in pregnancy.Major threats to optimal foetal thyroid function are inadequate or over aggressive anti

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Syzon, Оrysya О., Tetyana I. Rudnyk, and Marianna O. Dashko. "COMBINED DIFFERENTIATED THERAPY IN PATIENTS WITH URTICARIA." Wiadomości Lekarskie 72, no. 4 (2019): 589–94. http://dx.doi.org/10.36740/wlek201904116.

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Introduction: The necessity of the study of urticaria is called for by its high specific gravity in the structure of dermatoses, lack of effective therapies and, consequently, negative impact on the quality of life of patients and members of their families. Among the factors that initiate clinical manifestations of urticaria are autoimmune disorders, diseases of the gastrointestinal tract, nervous system, bacterial and viral infections, helminth infestation. However, the state of the internal secretion glands in such patients is understudied. Although, it is recognised that thyroid gland plays

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Petrov, N. M. "Treatment of diffuse toxic goiter with lithium electrophoresis." Kazan medical journal 67, no. 5 (1986): 333–35. http://dx.doi.org/10.17816/kazmj70586.

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The purpose of this work was to clinically evaluate the efficacy of lithium electrophoresis in some thyroid diseases. We examined 28 patients with primary toxic diffuse goiter aged from 20 to 54 years (2 men and 26 women). Seventeen patients had mild thyrotoxicosis, nine had moderate, and two had severe thyrotoxicosis. Diffuse increase of thyroid gland of I-II degree was found in 22 patients, III - in 6 patients. thyrogenic ophthalmopathy of I-II degree was observed in 6 patients. Conservative antithyroid therapy was required in 23 patients, and 5 patients underwent strumulectomy.

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Mizokami, Tetsuya, Katsuhiko Hamada, Tetsushi Maruta, Kiichiro Higashi, and Junichi Tajiri. "LONG-TERM OUTCOMES OF RADIOIODINE THERAPY FOR JUVENILE GRAVES DISEASE WITH EMPHASIS ON SUBSEQUENTLY DETECTED THYROID NODULES: A SINGLE INSTITUTION EXPERIENCE FROM JAPAN." Endocrine Practice 26, no. 7 (2020): 729–37. http://dx.doi.org/10.4158/ep-2019-0468.

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Objective: To investigate the long-term outcomes of radioiodine therapy (RIT) for juvenile Graves disease (GD) and the ultrasonographic changes of the thyroid gland. Methods: All of 117 juvenile patients (25 males and 92 females, aged 10 to 18 [median 16] years) who had undergone RIT for GD at our clinic between 1999 and 2018 were retrospectively reviewed. Each RIT session was delivered on an outpatient basis. The maximum 131I dose per treatment was 13.0 mCi, and the total 131I dose per patient was 3.6 to 29.8 mCi (median, 13.0 mCi). 131I administration was performed once in 89 patients, twice

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Tokle, Sheetal R. "A CLINICO-COMPARATIVE STUDY ON THE EFFECT OF LASHUNA SIDDHA TAILPANA POORVAK VAMANA KARMA AND NITYA VIRECHANA BY GOMUTRA HARITAKI IN THE MANAGEMENT OF HYPOTHYROIDISM." International Journal of Research in Ayurveda and Pharmacy 12, no. 4 (2021): 49–55. http://dx.doi.org/10.7897/2277-4343.1204105.

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Hypothyroidism is a condition in which thyroid gland doesn’t produce enough thyroid hormone. This is more prevalent among women. Management through levothyroxine is safe & may bring the value of Thyroid stimulating hormone and thyroxine to normal range but the increased dosage and continuous medication are cost expensive and make the patient into drug dependent till the end of mortal life. So, better, therapy is needed for the society through the heritage of Ayurveda especially with Shodhana therapy. Aim of Clinico-comparative study was to evaluate and compare the efficacy of Lashuna siddh

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Cabanillas, Maria E., Mimi I. Hu, Jean-Bernard Durand, and Naifa L. Busaidy. "Challenges Associated with Tyrosine Kinase Inhibitor Therapy for Metastatic Thyroid Cancer." Journal of Thyroid Research 2011 (2011): 1–9. http://dx.doi.org/10.4061/2011/985780.

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Tyrosine kinase inhibitors (TKIs) which target angiogenesis are promising treatments for patients with metastatic medullary and differentiated thyroid cancers. Sorafenib, sunitinib, and pazopanib are commercially available drugs which have been studied in these diseases. Vandetanib is the first drug approved in the United States for treatment of medullary thyroid cancer. These TKIs are used as chronic therapies, and therefore it is imperative to understand the adverse event profile in order to avoid excessive toxicity and maintain patients on therapy as long as it proves beneficial. Here we re

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de Carvalho, Gisah Amaral, Gilberto Paz-Filho, Cleo Mesa Junior, and Hans Graf. "MANAGEMENT OF ENDOCRINE DISEASE: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults." European Journal of Endocrinology 178, no. 6 (2018): R231—R244. http://dx.doi.org/10.1530/eje-17-0947.

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Hypothyroidism is one of the most common hormone deficiencies in adults. Most of the cases, particularly those of overt hypothyroidism, are easily diagnosed and managed, with excellent outcomes if treated adequately. However, minor alterations of thyroid function determine nonspecific manifestations. Primary hypothyroidism due to chronic autoimmune thyroiditis is largely the most common cause of thyroid hormone deficiency. Central hypothyroidism is a rare and heterogeneous disorder characterized by decreased thyroid hormone secretion by an otherwise normal thyroid gland, due to lack of TSH. Th

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Shin, Hye-Ji, Kyung-A. Hwang, and Kyung-Chul Choi. "Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers." Nutrients 11, no. 1 (2019): 125. http://dx.doi.org/10.3390/nu11010125.

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Thyroid cancers developed from the tissues of the thyroid gland are classified into papillary (PTC), follicular (FTC), medullary (MTC), and anaplastic thyroid cancer (ATC). Although thyroid cancers have been generally known as mild forms of cancer, undifferentiated MTC and ATC have a more unfavorable prognosis than differentiated PTC and FTC because they are more aggressive and early metastatic. A variety of therapies such as surgery, radiotherapy, and chemotherapy have been currently used to treat thyroid cancer, but they still have limitations including drug resistance or unfavorable side ef

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Laurberg, Peter, Birte Nygaard, Stig Andersen, et al. "Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves’ Disease Study." Journal of Thyroid Research 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/165487.

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Background. Graves’ disease may have a number of clinical manifestations with varying degrees of activity that may not always run in parallel.Objectives. To study associations between serum levels of TSH-receptor autoantibodies and the three main manifestations of Graves’ disease (hyperthyroidism, goiter, and presence of orbitopathy) at the time of diagnosis of hyperthyroidism.Methods. We describe a cohort of 208 patients with newly diagnosed Graves’ hyperthyroidism. Patients were enrolled in a multiphase study of antithyroid drug therapy of Graves’ hyperthyroidism, entitled “Remission Inducti

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Thakkar, Aditi, and Constance Lee Chen. "A Case for Lithium Pretreatment Prior to Radioactive Iodine Ablation in Grave’s Disease." Journal of the Endocrine Society 5, Supplement_1 (2021): A906—A907. http://dx.doi.org/10.1210/jendso/bvab048.1851.

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Abstract Radioactive iodine ablation (RAIA) therapy with Iodine-131 (I-131) is an established treatment for grave’s thyrotoxicosis. However, there is 10 to 20% chance of treatment failure. Lithium, a drug used to treat bipolar disorder, has significant effects on thyroid function. The most clinically relevant is the inhibition of thyroid hormone release. It is also known to inhibit colloid formation, and is involved in blocking organic iodine as well as thyroid hormone release from the thyroid gland without an effect on radioiodine uptake. This leads to increased radioiodine retention in the t

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Hernando, Jorge, Javier Ros, Alvaro Arroyo, and Jaume Capdevila. "Clinical and Translational Challenges in Thyroid Cancer." Current Medicinal Chemistry 27, no. 29 (2020): 4806–22. http://dx.doi.org/10.2174/0929867327666200214125712.

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Thyroid cancer is the most common endocrine malignancy and it accounts for 1% of all newly diagnosed tumors. Approximately 10% of patients with differentiated thyroid carcinomas (DTC) and 30% with medullary thyroid carcinoma (MTC) could not be cured with locoregional treatment and could develop metastatic disease. In addition, one of the most aggressive solid tumors can arise from the thyroid gland, the anaplastic thyroid carcinoma, with a median overall survival of less than 6 months. Currently, only four drugs are approved for the treatment of DTC and MTC and several unmet needs are focusing

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Ruyatkina, Lyudmila A., and Dmitriy S. Ruyatkin. "Subclinical hypothyroidism and metabolic syndrome: reasons for drug intervention." Obesity and metabolism 17, no. 1 (2020): 41–47. http://dx.doi.org/10.14341/omet12282.

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The high prevalence of metabolic syndrome (MS) and subclinical hypothyroidism (SHypo) creates danger of integral cardio-metabolic risk (CMR). A concept is being developed to increase thyroid-stimulating hormone (TSH) levels as a component of MS with the key role of insulin resistance (IR). To identify groups of active intervention, the definitions of SHypo with age and gender characteristics are analyzed. The results of randomized clinical trials showed a higher incidence of prediabetes and type 2 diabetes mellitus (T2DM) in SHypo, as well as positive associations of autoimmune thyroiditis (AI

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Sharova, Natalia, Tatiana Astakhova, Yaroslava Karpova, et al. "Changes in proteasome pool in human papillary thyroid carcinoma development." Open Life Sciences 6, no. 4 (2011): 486–96. http://dx.doi.org/10.2478/s11535-011-0040-x.

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AbstractSearching the antitumor drug targets among proteasomes, “ubiquitous” enzyme systems, may provide a new impulse to the antitumor drug discovery. In this study, changes in the proteasome pool in the development of human papillary thyroid carcinoma were determined. Proteasome activities were evaluated by hydrolysis of commercial fluorogenic peptides. Changes in the expression of the total proteasome pool, proteasome 19S activator and proteolytic constitutive subunits X(β5), Y(β1) and immune subunits LMP7 (β5i) and LMP2 (β1i) were investigated by Western blotting. The distribution of the p

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Ward, Laura S. "The difficult patient: drug interaction and the influence of concomitant diseases on the treatment of hypothyroidism." Arquivos Brasileiros de Endocrinologia & Metabologia 54, no. 5 (2010): 435–42. http://dx.doi.org/10.1590/s0004-27302010000500002.

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Although most hypothyroid patients do well with one single tablet of thyroxine daily, approximately 10% are dissatisfied and another important group of patients is difficult to control. We reviewed the most common causes for frequent-dose adjustment or high-dose requirement, including poor compliance with therapy and inadequate medication. Since these two causes have been ruled out, drug interaction and other concomitant diseases need to be investigated. Requirements of thyroxine increase in all conditions characterized by impaired gastric acid secretion. Proton-pump inhibitors, antacids and a

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Pidchenko, N. S. "The use of L-thyroxine in the treatment of thyroid pathologies and problems of therapy control (literature review)." Український радіологічний та онкологічний журнал 28, no. 4 (2020): 387–402. http://dx.doi.org/10.46879/ukroj.4.2020.387-402.

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Background. Thyroid disease is one of the most common pathologies in the world, wich includs hypothyroidism, hyperthyroidism and thyroid cancer. At the present, there is an increase in their cases. The thyroid gland is an extremely important for the health of a person, thyroid hormones are necessary for the normal functioning of all tissues in the body. Purpose. To structure and summarize scientific findings on the role of thyroid hormones (T4, T3 and rT3) in the development of hypothyroidism, their effect on inhibiting the growth of cancer cells and the cytotoxic effects of these hormon

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Beraja, D. J. "Influence of a method of treatment autoimmune thyroid gland pathologies on reproductive function of women." HEALTH OF WOMAN, no. 4(140) (May 30, 2019): 76–78. http://dx.doi.org/10.15574/hw.2019.140.76.

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The objective: to study influence of various methods of treatment of autoimmune diseases on genesial function of women. Materials and methods. Was made the analysis of various methods of treatment illness of Greyvsa at 103 women. Besides, the screening assessment of pathology thyroid gland was carried out made at 298 women with sterility (the main group) and at 50 women who have addressed in clinic for selection of a method of contraception (control group). Selection of patients was carried out by the opened method in process of the address of patients with sterility in unit of conservation an

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Lukhovytska, N. I. "Treatment of thyrotoxicosis with radioiodine (аnalytical review of literature and own clinical data)". Український радіологічний та онкологічний журнал 28, № 3 (2020): 241–54. http://dx.doi.org/10.46879/ukroj.3.2020.241-254.

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Background. Thyrotoxicosis syndrome is a severe disease of the thyroid that adversely affects functioning of almost all organs and body systems and can result in serious complications like ciliary arrhythmia, cardiovascular inefficiency, thyroid eye disease with visual deterioration, multi-organ failure. The choice of treatment strategy, its sequence and radioiodine therapy effectiveness in thyrotoxicosis and other non-oncological diseases of the thyroid gland is still a challenging issue in endocrinology and radiology. Purpose. To analyze the literature data regarding radionuclide treat

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Lukhovytska, N. I. "Treatment of thyrotoxicosis with radioiodine (аnalytical review of literature and own clinical data)". Український радіологічний та онкологічний журнал 28, № 3 (2020): 241–54. http://dx.doi.org/10.46879/ukroj.3.2020.241-254.

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Background. Thyrotoxicosis syndrome is a severe disease of the thyroid that adversely affects functioning of almost all organs and body systems and can result in serious complications like ciliary arrhythmia, cardiovascular inefficiency, thyroid eye disease with visual deterioration, multi-organ failure. The choice of treatment strategy, its sequence and radioiodine therapy effectiveness in thyrotoxicosis and other non-oncological diseases of the thyroid gland is still a challenging issue in endocrinology and radiology. Purpose. To analyze the literature data regarding radionuclide treat

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