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Journal articles on the topic 'Thyroid hormones Therapeutic use'

Author: Grafiati

Published: 10 December 2022

Last updated: 31 July 2025

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1

Rupeć, Zuzanna, Mateusz Trubalski, Zeeshan Zulfiquar, et al. "Hormonal Influence on Osteoporosis." Wiadomości Lekarskie, no. 3 (March 29, 2025): 531–38. https://doi.org/10.36740/wlek/202332.

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Osteoporosis is a global health issue that weakens bones and increases the risk of fractures, particularly in postmenopausal women and older adults. This review explores the influence of hormones on osteoporosis, with a focus on estrogen, glucocorticoids, vitamin D, parathyroid hormone, and thyroid hormones. Scientific evidence is analyzed to highlight hormonal mechanisms, therapeutic interventions, and their effects on bone health. The review examines hormonal therapies, including selective estrogen receptor modulators, and discusses the impact of glucocorticoids, essential for managing infla

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Park, Sang-In, Young Joon Lee, Seong Hun Choi, Soo Jin Park, Chang-Hyun Song, and Sae-Kwang Ku. "Therapeutic Effects of Blue Honeysuckle on Lesions of Hyperthyroidism in Rats." American Journal of Chinese Medicine 44, no. 07 (2016): 1441–56. http://dx.doi.org/10.1142/s0192415x16500804.

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Hyperthyroidism is a hypermetabolic syndrome characterized by an overproduction of thyroid hormones, which enhances the hormone-induced oxidative stress responsible for some complications in the liver, heart and muscle. Blue honeysuckle (BH) is an edible berry, rich in polyphenols, especially flavonoids or anthocyanins, known as strong antioxidants. The chemo-protective activities of the berry have been connected to the improvement of symptoms in cancer, diabetes mellitus, tumor or cardiovascular diseases. Therefore, the therapeutic effects of BH were examined in hyperthyroidism rat model. The

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Pekic, Sandra, and Vera Popovic-Brkic. "Advances in Our Understanding of Pituitary Adenoma." US Endocrinology 04, no. 01 (2008): 88. http://dx.doi.org/10.17925/use.2008.04.01.88.

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Pituitary adenomas are common benign monoclonal neoplasms— accounting for 15% of intracranial neoplasms—that may be clinically silent or secrete anterior pituitary hormones such as prolactin, growth hormone (GH), adrenocorticotrophic hormone (ACTH), or, rarely, thyroid-stimulating hormone (TSH) or gonadotrophins. Radiological studies for other reasons using high-resolution computed tomography (CT) or magnetic resonance imaging (MRI) detect incidental pituitary adenomas in approximately 20% of asymptomatic patients.1The incidence of the various types of adenoma varies;2prolactinomas are the mos

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Alvarez-Salas, Elena, Cinthia García-Luna, and Patricia de Gortari. "New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent." International Journal of Molecular Sciences 24, no. 13 (2023): 11047. http://dx.doi.org/10.3390/ijms241311047.

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Thyrotropin-releasing hormone (TRH) is a tripeptide that regulates the neuroendocrine thyroid axis. Moreover, its widespread brain distribution has indicated that it is a relevant neuromodulator of behaviors such as feeding, arousal, anxiety, and locomotion. Importantly, it is also a neurotrophic peptide, and thus may halt the development of neurodegenerative diseases and improve mood-related disorders. Its neuroprotective actions on those pathologies and behaviors have been limited due to its poor intestinal and blood–brain barrier permeability, and because it is rapidly degraded by a serum e

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Brossaud, J., V. Pallet, and J.-B. Corcuff. "Vitamin A, endocrine tissues and hormones: interplay and interactions." Endocrine Connections 6, no. 7 (2017): R121—R130. http://dx.doi.org/10.1530/ec-17-0101.

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Vitamin A (retinol) is a micronutrient critical for cell proliferation and differentiation. In adults, vitamin A and metabolites such as retinoic acid (RA) play major roles in vision, immune and brain functions and tissue remodelling and metabolism. This review presents the physiological interactions of retinoids and endocrine tissues and hormonal systems. Two endocrine systems have been particularly studied. In the pituitary, retinoids target the corticotrophs with a possible therapeutic use in corticotropinomas. In the thyroid, retinoids interfere with iodine metabolism and vitamin A deficie

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Groeneweg, Stefan, Robin P. Peeters, Theo J. Visser, and W. Edward Visser. "Diagnostic and Therapeutic Challenges in the Allan—Herndon—Dudley Syndrome." US Endocrinology 12, no. 02 (2016): 90. http://dx.doi.org/10.17925/use.2016.12.02.90.

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Thyroid hormone (TH) is important for normal brain development. The TH transporter protein monocarboxylate transporter 8 (MCT8) is crucial to maintain adequate TH levels in the brain during development and throughout life. Mutations in MCT8 result in the Allan–Herndon–Dudley syndrome (AHDS), which is characterized by a severe delay in neurocognitive development, combined with abnormal serum thyroid function tests (TFTs). The combination of an increased (F)T3 and decreased (F)T4 and rT3 serum levels are characteristic for the presence of AHDS in male patients with moderate to severe delay in ne

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Celi, Francesco S. "A MUCH-NEEDED HISTORIC PERSPECTIVE ON THE THERAPEUTIC USE OF THYROID HORMONES." Endocrine Practice 21, no. 10 (2015): 1171–74. http://dx.doi.org/10.4158/ep15875.co.

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Korbozova, Nazym K., Nataliya O. Kudrina, Nataliya A. Zhukova, et al. "Antihypothyroid Effect of Salidroside." Molecules 27, no. 21 (2022): 7487. http://dx.doi.org/10.3390/molecules27217487.

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In terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of thyroid hypofunction and its complications is urgent. Salidroside is a glucoside of tyrosol, found mostly in the roots of Rhodiola spp., and has various positive biological activities. The purpose of this study was to study the antihypothyroid potential of salidrosid-containing extract from R. semenovii roots, wh

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Janett-Pellegri, Camilla, Lea Wildisen, Martin Feller, et al. "Prevalence and factors associated with chronic use of levothyroxine: A cohort study." PLOS ONE 16, no. 12 (2021): e0261160. http://dx.doi.org/10.1371/journal.pone.0261160.

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Importance Levothyroxine prescriptions are rising worldwide. However, there are few data on factors associated with chronic use. Objective To assess the prevalence of chronic levothyroxine use, its rank among other chronic drugs and factors associated with chronic use. To assess the proportion of users outside the therapeutic range of thyroid-stimulating hormone (TSH). Design Cohort study (CoLaus|PsyCoLaus) with recruitment from 2003 to 2006. Follow-ups occurred 5 and 10 years after baseline. Participants A random sample of Lausanne (Switzerland) inhabitants aged 35–75 years. Main outcomes We

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Malova, Natalia, Larysa Syrotenko, Irina Komarova, Yuriy Karachentsev, Vadym Khaziyev, and Vitaly Varavin. "Pathogenetic Approach to the Use of a Non-hormonal Drug for Correction of Experimental Thyroid Pathology." American Journal of Clinical and Experimental Medicine 13, no. 3 (2025): 63–67. https://doi.org/10.11648/j.ajcem.20251303.15.

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Today, hypothyroidism of various origins affects about 10% of the Earth&apos;s population. The relevance of this work is due to the absence of original harmless and effective natural products on the domestic and global pharmaceutical market, which can be used both to normalize the immune system and to restore the functional activity of the thyroid gland and reduce the level of associated complications. In modern endocrinology, fetal biological products, including cord blood products, can be a certain alternative to replacement therapy (or in combination with it). The aim of the work was to

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Barwinek, Katarzyna, Danuta Gąsior-Perczak, Sławomir Trepka, et al. "Effective Preoperative Plasmapheresis Treatment of Severe Hyperthyroidism in a Patient with Giant Toxic Nodular Goiter and Methimazole-Induced Agranulocytosis." Medicina 56, no. 6 (2020): 290. http://dx.doi.org/10.3390/medicina56060290.

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Agranulocytosis is a rare but very serious complication of thyrostatic therapy. In severe hyperthyroidism, the removal of circulating thyroid hormones by plasmapheresis may be an effective therapeutic option. This report describes the therapeutic difficulties and successful preoperative treatment with plasmapheresis in a 63-year-old patient admitted to the Endocrinology Clinic with severe hyperthyroidism, during the course of giant toxic nodular goiter and agranulocytosis, which occurred after 2 weeks of taking methimazole. During hospitalization, methimazole treatment was discontinued and the

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Morales, Hugo-Alberto Martínez, Alma Vergara López, Ángel Ramón Gallegos, and Viridiana Mancilla Hernández. "Use of Plasmapheresis in the Treatment of Thyrotoxicosis Secondary to Graves' Disease at the National Medical Center 20 de Noviembre ISSSTE: Case Report." South Asian Research Journal of Medical Sciences 5, no. 04 (2023): 101–5. http://dx.doi.org/10.36346/sarjms.2023.v05i04.003.

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Thyrotoxicosis refers to the clinical syndrome secondary to excess of circulating thyroid hormones, thyroid storm is an extreme manifestation of thyrotoxicosis, and which can reach 10-30% mortality with treatment depending on the series. This rare but serious complication occurs mainly in patients with Graves' disease (GD) who account for 60% to 80% of cases of hyperthyroidism. Both plasmapheresis/therapeutic plasma exchange (TPE) and emergency surgery have been used to treat thyroid storm in patients who respond poorly to first-line therapeutic measures. We present the case report of three pa

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Safer, Joshua D. "Thyroid Hormone and Wound Healing." Journal of Thyroid Research 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/124538.

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Although thyroid hormone is one of the most potent stimulators of growth and metabolic rate, the potential to use thyroid hormone to treat cutaneous pathology has never been subject to rigorous investigation. A number of investigators have demonstrated intriguing therapeutic potential for topical thyroid hormone. Topical T3has accelerated wound healing and hair growth in rodents. Topical T4has been used to treat xerosis in humans. It is clear that the use of thyroid hormone to treat cutaneous pathology may be of large consequence and merits further study. This is a review of the literature reg

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Vegt, M., J. A. Bruijn, and T. K. Birkenhäger. "The use of thyroid hormone in the treatment of depression: a review." Acta Neuropsychiatrica 3, no. 2 (1991): 17–21. http://dx.doi.org/10.1017/s0924270800035006.

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SummaryThe writers of this paper made an inventory of the studies on the use of thyroid hormone in the treatment of depression. Fifteen clinical trials (353 patients), published between 1969 and 1987. were found, that can be described, as to their design, in two seperate groups:One group (7 studies) administers thyroid hormone simultaneously with a tricyclic antidepressant to reach a faster effect of the antidepressant. The other group (8 studies) adds thyroid hormone to a tricyclic antidepressant in patients who fail to respond to this treatment, with the aim to convert therapeutic failure to

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Giuliani, Cesidio, Giulia Di Dalmazi, Ines Bucci, and Giorgio Napolitano. "Quercetin and Thyroid." Antioxidants 13, no. 10 (2024): 1202. http://dx.doi.org/10.3390/antiox13101202.

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Quercetin is the most abundant flavonoid present in fruits and vegetables. For its antiproliferative, antiviral, anti-inflammatory and antioxidants activities, it is an active ingredient of several herbal remedies and is available as a nutraceutical. Experimental studies performed in vitro have demonstrated that quercetin inhibits growth and function in normal thyroid cells and may act as a thyroid disruptor. These effects have also been confirmed in vivo using rodent models. Some studies have reported the ability of quercetin to interfere with the metabolism of thyroid hormones, since it inhi

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GOEDE, SIMON L., KEITH R. LATHAM, MELVIN KHEE-SHING LEOW, and JACQUELINE JONKLAAS. "HIGH RESOLUTION FREE TRIIODOTHYRONINE-THYROTROPIN (FT3-TSH) RESPONSES TO A SINGLE ORAL DOSE OF LIOTHYRONINE IN HUMANS: EVIDENCE OF DISTINCT INTER-INDIVIDUAL DIFFERENCES UNRAVELED USING AN ELECTRICAL NETWORK MODEL." Journal of Biological Systems 25, no. 01 (2017): 119–43. http://dx.doi.org/10.1142/s0218339017500073.

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The effects of a single oral dose of liothyronine (L-T3) on thyroid stimulating hormone (TSH) and other related thyroid system parameters are partly understood despite therapeutic use of this hormone over many decades. We characterize individualized responses of the hypothalamus-pituitary-thyroid (HPT) axis and its related temporal hormonal profile using an electrical network model. Based on thyroid hormone responses from blood samples using a single 50[Formula: see text][Formula: see text]g oral dose of liothyronine in healthy persons with a normal operating euthyroid feedback HPT system, we

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Ruggero Errante, Paolo. "A case report of association between canine iatrogenic hyperadrenocorticism and hypothyroidism." Journal of Dairy, Veterinary & Animal Research 13, no. 1 (2024): 12–14. http://dx.doi.org/10.15406/jdvar.2024.13.00340.

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The canine hypothyroidism corresponds to a hormonal disorder, mainly caused by destruction of the thyroid gland, followed by idiopathic thyroid degeneration or idiopathic follicular atrophy, leading to a low production of the hormones thyroxine (T4) and triiodothyronine (T3). The canine iatrogenic hyperadrenocorticism consists of a disorder caused by the prolonged use of corticosteroids for therapeutic purposes, in most cases in allergic processes, such as canine atopy. In this case report, a twelve-year-old female Schnauzer was presented to the clinical facility with signs of apathy, polyphag

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Meissner, Henry, H. Reich-Bilinska, A. Mscisz, and B. Kedzia. "Therapeutic Effects of Pre-Gelatinized Maca (Lepidium peruvianum Chacon) used as a non-hormonal alternative to HRT in perimenopausal women - Clinical Pilot Study." International Journal of Biomedical Science 2, no. 2 (2006): 143–59. http://dx.doi.org/10.59566/ijbs.2006.2143.

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Background: Roots of cruciferous plant Lepidium peruvianum Chacon cultivated in high plateaus of Andes and known under its common name Maca, have been traditionally-used as an energizing vegetable with therapeutic properties for both men and women. Maca has been recognized by natives of Peru as herbal remedy helping to treat conditions affecting menopausal women. Objective: The effects of Pre-Gelatinized Organic Maca (Maca-GO) on quantitative physiological responses and alleviation of symptoms contributing to menopausal discomfort in perimenopausal women was examined.Methods: In this, four mon

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Veeramachaneni, Ravali, Ravali Veeramachaneni, Samantha Milanes, and Daniela Pirela-Araque. "ODP524 Thyroid Storm Precipitated by COVID-19 Infection: A Case Report." Journal of the Endocrine Society 6, Supplement_1 (2022): A785. http://dx.doi.org/10.1210/jendso/bvac150.1623.

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Abstract Background Thyroid storm is an endocrinological emergency caused by severe thyrotoxicosis. COVID-19, caused by the novel coronavirus SARS-CoV-2, is known to cause thyroid-related complications of subacute thyroiditis but the occurrence of thyroid storm is rare. The use of first line therapies for thyrotoxicosis/thyroid storm, such as thioamides, radioactive iodine, and surgery, may be precluded by leukopenia, hemodynamic instability, and liver failure, which are commonly seen in severe COVID-19 infection. The necessity for isolation creates a challenge for surgical intervention for th

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Savchuk, Tatiana. "Thyroid gland – historical essay." Current issues of social sciences and history of medicine 30, no. 2 (2021): 88–90. http://dx.doi.org/10.24061/2411-6181.2.2021.275.

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Formulation of the problem. The first imagest hyroid gland can be found in ancient Egyptian and ancient Chinese sculptures date back 2700 years to oursera. Historiographical base. The thyroid gland was known already the authors of antiquity and the Middle Ages, although they described goiter and cretinism, but have not yet linked these diseases to the disorder gland function. The purpose of the study - to analyze the historical milestones in the formation of thyroidology. Main part. As early as 1600 year BC were among the first, Chinese doctors in treatment of enlarged thyroid gland steel use

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Fragu, Philippe. "Calcitonin’s Fantastic Voyage: from Hormone to Marker of a Genetic Disorder." Gesnerus 64, no. 1-2 (2007): 69–92. http://dx.doi.org/10.1163/22977953-0640102004.

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The story of thyroid calcitonin is an illuminating example of the voyage of hormone from a therapeutic tool for bone disease to a tumour marker to screen for subclinical forms of cancer. Identified as a new thyroid hormone implicated in calcium metabolism, its pharmacological action offered a new therapeutic tool for the management of bone disease. By measuring the circulating calcitonin, a range of values was obtained for oncologists because the evolution of a newly identified form of thyroid cancer – medullary (MTC) – was poorly understood. Researchers’ interest shifted from calcitonin physi

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Strilić, David, Bojan Stanimirov, and Maja Đanić. "Biotin interference with laboratory test results." Hospital Pharmacology - International Multidisciplinary Journal 11, no. 3 (2024): 1509–28. https://doi.org/10.5937/hpimj2403509s.

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Introduction: Biotin interference in laboratory tests is a growing concern, particularly due to the widespread use of biotin not only as a therapeutic agent but also as a supplement in the cosmetic industry. Immunoassays utilizing biotin-streptavidin technology are especially susceptible to interference, which can result in inaccurate test results, misdiagnosis, and inappropriate treatment. Methodology: This review synthesizes information from scientific literature available through databases like PubMed and Google Scholar. Keywords such as "biotin", "interference" and "immunoassay" were used

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Cadeliña, Jekrylei, Michael Villa, Hanna Jessa Morales, and Ferdinand Santoceldes. "ODP536 Rapid, Successful Control of Thyrotoxicosis Using Therapeutic Plasma Exchange as a Bridge to Thyroidectomy in an Adult Patient With Cardiogenic Shock and Hepatic Dysfunction." Journal of the Endocrine Society 6, Supplement_1 (2022): A791. http://dx.doi.org/10.1210/jendso/bvac150.1635.

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Abstract Background Uncontrolled Graves’ disease is associated with significant morbidity and mortality. Treatment of such patients who have developed multi-organ dysfunction is challenging, and novel interventions have to be explored. We present a case of uncontrolled thyrotoxicosis with cardiogenic shock and hepatic dysfunction successfully controlled using therapeutic plasma exchange as a bridge to definitive management with total thyroidectomy. Case Presentation Our patient is a 36-year-old Filipina with known Graves’ disease for three years but with poor compliance to medications. She was

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Grbovic, Leposava, and Miroslav Radenkovic. "Therapeutic use of glucocorticoids and immunosuppressive agents." Srpski arhiv za celokupno lekarstvo 133, Suppl. 1 (2005): 67–73. http://dx.doi.org/10.2298/sarh05s1067g.

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Pharmacotherapy of autoimmune thyroid disease (AITD) is complex. Apart from the replacement hormone therapy, antithyroid agents, beta adrenoceptor blockers and other drugs, in regard to the present symptoms, it also includes the administration of glucocorticoids and immunosuppressive agents. Physiological actions of glucocorticoids are significant in number, well known and described in details. The most prominent pharmacological properties of glucocorticoids, that are important for their clinical use, are antiinflammatory and immunosuppressive actions. In this article, the most notable clinica

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Segocio, Donnie Jan D., and Joseph E. Cachuela. "Levothyroxine versus Levothyroxine with Iodine in Reduction of Thyroid Nodule Volume: A Double-Blind Randomized Controlled Trial." Philippine Journal of Otolaryngology-Head and Neck Surgery 34, no. 1 (2019): 14–19. http://dx.doi.org/10.32412/pjohns.v34i1.959.

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Objective: To compare levothyroxine alone and in combination with iodine on thyroid nodule volume reduction. Methods:  Design: Double-Blind Randomized Controlled Trial Setting: Tertiary Government Hospital Participants: Nineteen (19) euthyroid patients age 19-54 with at least 1 cytologically benign thyroid nodule were randomized to receive either levothyroxine + iodine or levothyroxine + placebo, taken once a day for 6 months with ultrasound and thyroid stimulating hormone monitoring on the 3rd and 6th month of intervention. Results: Main outcome measures include

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Carvalho, Denise P., and Andrea C. F. Ferreira. "The importance of sodium/iodide symporter (NIS) for thyroid cancer management." Arquivos Brasileiros de Endocrinologia & Metabologia 51, no. 5 (2007): 672–82. http://dx.doi.org/10.1590/s0004-27302007000500004.

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The thyroid gland has the ability to uptake and concentrate iodide, which is a fundamental step in thyroid hormone biosynthesis. Radioiodine has been used as a diagnostic and therapeutic tool for several years. However, the studies related to the mechanisms of iodide transport were only possible after the cloning of the gene that encodes the sodium/iodide symporter (NIS). The studies about the regulation of NIS expression and the possibility of gene therapy with the aim of transferring NIS gene to cells that normally do not express the symporter have also become possible. In the majority of hy

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S., О. Shurpyak. "THE SUBSTANTIATION OF DIFFERENTIATED THERAPY OF THE COMBINED DISGORMONAL PATHOLOGY OF REPRODUCTIVE ORGANS IN WOMEN OF REPRODUCTIVE AGE WITH COMORBID CONDITIONS." Reproductive health of woman 2 (August 31, 2020): 5–10. https://doi.org/10.30841/2708-8731.2.2020.210946.

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The objective: substantiation of the differentiated therapeutic approaches to the treatment of the combined dyshormonal pathology of the reproductive organs, taking into account the comorbidity of the patients. Materials and methods. The study involved 300 women of reproductive age (20 - 42 years, an average of 29.9±5.6 years). The examination included ultrasonographic examination of the pelvic organs, mammary glands, thyroid gland, determination of the levels of pituitary tropic hormones and ovarian steroid hormones, thyroid hormones, antibodies to thyroperoxidase, serum levels 25 (OH)

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SERAFINI, ALDO N., RALF P. CLAUSS, and SILVINA LEVIS-DUSSEAU. "Protocol for the Combined Diagnostic and Therapeutic Use of Recombinant Human Thyroid-Stimulating Hormone." Clinical Nuclear Medicine 28, no. 1 (2003): 14–17. http://dx.doi.org/10.1097/00003072-200301000-00004.

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Feldt-Rasmussen, Ulla. "Subclinical Hypothyroidism and Cardiovascular Risk—An Overview of Current Understanding." US Endocrinology 06, no. 01 (2010): 92. http://dx.doi.org/10.17925/use.2010.06.1.92.

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Subclinical or mild hypothyroidism is often associated with adverse cardiovascular risk factors, such as high cholesterol, together with hypertension, endothelial dysfunction and other atherosclerotic cardiovascular risk factors. The ischemic abnormalities are probably related to long-term consequences of a slowly progressing development of hypothyroidism. In recent years, it has become evident that a consensus on the exact limits for cut-off between normal and subclinically hypothyroid individuals is not currently possible. The main reasons for this are differences for measurement of serum th

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Codrich, Marta, Alessia Biasotto, and Federica D’Aurizio. "Circulating Biomarkers of Thyroid Cancer: An Appraisal." Journal of Clinical Medicine 14, no. 5 (2025): 1582. https://doi.org/10.3390/jcm14051582.

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Thyroid cancer is the most prevalent endocrine cancer. The prognosis depends on the type and stage at diagnosis. Thyroid cancer treatments involve surgery, possibly followed by additional therapeutic options such as hormone therapy, radiation therapy, targeted therapy and chemotherapy. Besides the well-known thyroid tumor biomarkers, new circulating biomarkers are now emerging. Advances in genomic, transcriptomic and proteomic technologies have allowed the development of novel tumor biomarkers. This review explores the current literature data to critically analyze the benefits and limitations

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Rodpai, Rutchanee, Oranuch Sanpool, Tongjit Thanchomnang, et al. "Exposure to dexamethasone modifies transcriptomic responses of free-living stages of Strongyloides stercoralis." PLOS ONE 16, no. 6 (2021): e0253701. http://dx.doi.org/10.1371/journal.pone.0253701.

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Hyperinfection and disseminated infection by the parasitic nematode Strongyloides stercoralis can be induced by iatrogenic administration of steroids and immunosuppression and lead to an elevated risk of mortality. Responses of free-living stages of S. stercoralis to the therapeutic corticosteroid dexamethasone (DXM) were investigated using RNA-seq transcriptomes of DXM-treated female and male worms. A total of 17,950 genes representing the transcriptome of these free-living adult stages were obtained, among which 199 and 263 were differentially expressed between DXM-treated females and DXM-tr

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Tulsky, A. A., O. A. Myrinova, A. O. Shchetinina, et al. "Association between gut microbiota and thyroid dysfunction." Meditsinskiy sovet = Medical Council, no. 6 (May 20, 2024): 240–49. http://dx.doi.org/10.21518/ms2024-073.

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The article is devoted to modern researches about the potential role of gut microbiota in the development of thyroid pathology. Gut microbiota plays a major role both in the formation and maintenance of human health and in the pathogenesis of a wide range of diseases. There is evidence of the relationship between the gut microbiota and the immune system, the risk of developing several malignant and autoimmune diseases. The article discusses the functions of the gut microbiota and the factors that determine its composition. Studies have shown a connection between the gut microbiota and the thyr

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Duntas, Leonidas H., and Bernadette Biondi. "Short-term hypothyroidism after Levothyroxine-withdrawal in patients with differentiated thyroid cancer: clinical and quality of life consequences." European Journal of Endocrinology 156, no. 1 (2007): 13–19. http://dx.doi.org/10.1530/eje.1.02310.

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Acute hypothyroidism induced by thyroid hormone withdrawal in patients with differentiated thyroid cancer during monitoring for remnant or metastatic disease, seriously affects multiple organs and systems, and especially in severe cases can impair quality of life. Indeed, it may induce untoward cardiovascular effects and can be hazardous in patients with underlying cardiovascular disease, particularly in the elderly. Moreover, acute hypothyroidism deranges the lipid profile and exacerbates neuropsychiatric illness. The introduction of recombinant human TSH (rhTSH) as a diagnostic and therapeut

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Liu, Yingheng, Dajun Wang, Rebecca A. Redetzke, Benjamin A. Sherer, and A. Martin Gerdes. "Thyroid hormone analog 3,5-diiodothyropropionic acid promotes healthy vasculature in the adult myocardium independent of thyroid effects on cardiac function." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 5 (2009): H1551—H1557. http://dx.doi.org/10.1152/ajpheart.01293.2008.

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Patients with hypothyroidism are at a higher risk for coronary vascular disease. Patients with diabetes and related vascular complications also have an increased incidence of low thyroid function. While thyroid hormones (THs) may be key regulators of a healthy vasculature, potential undesirable side effects hinder their use in the treatment of vascular disorders. TH analogs such as 3,5-diiodothyropropionic acid (DITPA) may provide a safer treatment option. However, the relative potency of DITPA on vascular growth, cardiac function, and metabolism is poorly understood. We hypothesized that the

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Buryak, V. M., та E. S. Murashko. "Особенности формирования, клинических проявлений и терапии диффузного нетоксического зоба у детей". Likarska sprava, № 3-4 (26 червня 2012): 31–35. http://dx.doi.org/10.31640/ls-2012-(3-4)-05.

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The paper deals with the peculiarities of formation, clinical presentations and therapy of diffuse nontoxic goiter of children. The paper highlights the connection of the disease with the genetic predisposition, the impact of natural and anthropogenic strumagenes, immune processes. The clinical presentations of the diffuse nontoxic goiter are diffuse enlargement of thyroid gland, normal or high level of thyrotropichypophysis hormone when the content of thyroxin and triiodothyronine is normal, which is treated as the subclinic hypothyroidism syndrome. The variety of the disease pathogenesis the

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Dr Saurabh Sharma and Dr Shalu Munjal. "Efficacy of Natrum Muriaticum in the Management of Hypothyroidism: A Clinical Case-Based Study." Universal Research Reports 11, no. 4 (2024): 361–69. https://doi.org/10.36676/urr.v11.i4.1497.

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Hypothyroidism, a prevalent endocrine disorder, is characterized by insufficient production of thyroid hormones, leading to clinical manifestations such as chronic fatigue, weight gain, cold intolerance, menstrual irregularities, and cognitive sluggishness. “Conventional medical treatment primarily includes lifelong administration of levothyroxine, which often lacks a personalized therapeutic approach and may not adequately address underlying constitutional imbalances. Homeopathy, on the other hand, offers a holistic and individualized treatment paradigm based on the principle of like cures li

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Nikolic, Aleksandra, Dragan Micic, Dejan Nikolic, and Violeta Stanimirovic. "Trab determination in newly detected patients with hyperthyroidism and their prognostic importance." Medical review 62, no. 7-8 (2009): 304–7. http://dx.doi.org/10.2298/mpns0908304n.

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Introduction. In more than 50 years since the first demonstration of the immune basis for thyroiditis was done, the autoimmune disease has been identified as a major cause of disfunction of all endocrine organs. Identification of the antithyroid with the radio-receptor assay is widespread in clinical use for differential diagnosis of other thyroid disorders manifesting with the hyperthyroidism. Material and methods. Our study included 44 patients with new onset Graves disease which was primarily verified according to the objective status of the patients (signs of hyperthyroidism), biochemical

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Chugh, Radhika, and Wiley Harkens. "RF23 | PSAT301 Plasmapheresis and Extracorporeal Membrane Oxygenation (ECMO) for Treatment of Thyroid Storm with Multiorgan Failure." Journal of the Endocrine Society 6, Supplement_1 (2022): A858—A859. http://dx.doi.org/10.1210/jendso/bvac150.1775.

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Abstract Introduction Thyroid storm is a life-threatening condition with a high morbidity and mortality rate. It can lead to severe end organ damage including liver injury, which can preclude the use of thionamides. Therapeutic plasma exchange can be a lifesaving option for treatment of thyroid storm in such cases. Multiorgan failure can also necessitate the use of extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT). Case Presentation A 34-year-old woman with a history of Graves’ disease, untreated for several years, presented to the emergency department

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Candellone, Alessia, Vittorio Saettone, Paola Badino, et al. "Management of Feline Hyperthyroidism and the Need to Prevent Oxidative Stress: What Can We Learn from Human Research?" Antioxidants 10, no. 9 (2021): 1496. http://dx.doi.org/10.3390/antiox10091496.

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Feline hyperthyroidism is a clinical syndrome related to an excessive production of thyroid hormones, and it is considered as a spontaneous animal model for human thyrotoxicosis. Many shared features between the feline and the human disease have been identified so far, including pathogenesis, clinical signs, and treatment options. Although methimazole is considered the first-choice drug in both species, several side effects have been described. Furthermore, methimazole could interfere with the oxidative status, already perturbated by the disease. It has been reported in humans that dietary man

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Csako, Gyorgy, Diane M. Corso, Jane Kestner, Allan D. Bokser, Paul E. Kennedy, and Frank Pucino. "Evaluation of Two Over-the-Counter Natural Thyroid Hormone Preparations in Human Volunteers." Annals of Pharmacotherapy 26, no. 4 (1992): 492–94. http://dx.doi.org/10.1177/106002809202600408.

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OBJECTIVE: To determine the pharmacologic activity of over-the-counter (OTC) thyroid preparations. DESIGN: In vitro analysis and a prospective, crossover study in vivo. SETTING: Tertiary care center. PARTICIPANTS: Two healthy adult volunteers INTERVENTION: Three OTC preparations (Thytrophin PMG [bovine thyroid PMG extract], Thyro Forte [thyroid lyphogland concentrate with synergistic complex], and Thyro Complex [thyroid lyophilized gland concentrate with synergistic complex]) were analyzed in vitro. Volunteers were administered two times the manufacturer's maximum recommended daily dose of eit

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Medenica, Sanja, Dzihan Abazovic, Aleksandar Ljubić, et al. "The Role of Cell and Gene Therapies in the Treatment of Infertility in Patients with Thyroid Autoimmunity." International Journal of Endocrinology 2022 (August 30, 2022): 1–10. http://dx.doi.org/10.1155/2022/4842316.

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There is a rising incidence of infertility worldwide, and many couples experience difficulties conceiving nowadays. Thyroid autoimmunity (TAI) is recognized as one of the major female infertility causes related to a diminished ovarian reserve and potentially impaired oocyte maturation and embryo development, causing adverse pregnancy outcomes. Growing evidence has highlighted its impact on spontaneously achieved pregnancy and pregnancy achieved by in vitro fertilization. Despite the influence of thyroid hormones on the male reproductive system, there is insufficient data on the association bet

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Farag, Amina A., Mahmoud Mostafa, Reham M. Abdelfatah, et al. "Ellagic Acid Alleviates Imidacloprid-Induced Thyroid Dysfunction via PI3K/Akt/mTOR-Mediated Autophagy." Toxics 13, no. 5 (2025): 355. https://doi.org/10.3390/toxics13050355.

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Imidacloprid (IMI) is a widely used insecticide known for its high selectivity toward insects. Ellagic acid (EA) is a plant-derived polyphenolic compound recognized for its therapeutic potential and favorable safety profile in the treatment of various diseases. This study aimed to evaluate the therapeutic effects of EA, formulated as novasomes (NOV), against IMI-induced thyroid dysfunction and to investigate the underlying mechanisms. Rats were divided into four equal groups: control, EA-NOV, IMI, and IMI + EA-NOV. Thyroid function was assessed by measuring free triiodothyronine (T3), free thy

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Groeneweg, Stefan, Robin P. Peeters, Theo J. Visser, and W. Edward Visser. "Triiodothyroacetic acid in health and disease." Journal of Endocrinology 234, no. 2 (2017): R99—R121. http://dx.doi.org/10.1530/joe-17-0113.

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Thyroid hormone (TH) is crucial for development and metabolism of many tissues. The physiological relevance and therapeutic potential of TH analogs have gained attention in the field for many years. In particular, the relevance and use of 3,3′,5-triiodothyroacetic acid (Triac, TA3) has been explored over the last decades. Although TA3 closely resembles the bioactive hormone T3, differences in transmembrane transport and receptor isoform-specific transcriptional activation potency exist. For these reasons, the application of TA3 as a treatment for resistance to TH (RTH) syndromes, especially MC

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Giovanella, Luca, Federica D’Aurizio, Petra Petranović Ovčariček, and Rainer Görges. "Diagnostic, Theranostic and Prognostic Value of Thyroglobulin in Thyroid Cancer." Journal of Clinical Medicine 13, no. 9 (2024): 2463. http://dx.doi.org/10.3390/jcm13092463.

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Thyroglobulin (Tg) is an iodinated glycoprotein, which is normally stored in the follicular colloid of the thyroid, being a substrate for thyroid hormone production. Since it is produced by well-differentiated thyroid cells, it is considered a reliable tumor marker for patients with differentiated thyroid carcinoma (DTC) during their follow-up after total thyroidectomy and radioiodine ablation. It is used to monitor residual disease and to detect recurrent disease. After total thyroid ablation, unstimulated highly sensitive Tg measurements are sufficiently accurate to avoid exogenous or endoge

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Ringel, M. D., and P. W. Ladenson. "Controversies in the follow-up and management of well-differentiated thyroid cancer." Endocrine-related cancer 11, no. 1 (2004): 97–116. http://dx.doi.org/10.1677/erc.0.0110097.

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Thyroid cancer is a common malignancy with an apparent increasing incidence and a wide spectrum of clinical behavior and therapeutic responsiveness. Recent advances in diagnosis, primary treatment, and long-term monitoring have led to enhanced detection of primary and recurrent disease and improvements in therapy. Controversy still surrounds several issues: the most accurate predictive staging system and histological subclassification scheme, optimal preoperative assessment and surgical extent, appropriate use of radioiodine for remnant ablation, goal for thyrotropin-suppressive thyroid hormon

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Fux Otta, Carolina, Laura Moreno, Roberto Vitaloni, and Gabriel S. Iraci. "Favorable outcome of SARS-CoV-2 infection in a patient with pituitary insufficiency." Revista de la Facultad de Ciencias Médicas de Córdoba 77, no. 4 (2020): 363–66. http://dx.doi.org/10.31053/1853.0605.v77.n4.29997.

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Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak originated in Wuhan (China) rapidly turned into a pandemic. Due to a national compulsive decree of quarantine, office visits for chronic disease control were delay. Hypopituitarism includes all clinical conditions that result in partial or complete failure of the pituitary gland's ability to secrete hormones. Pituitary insufficiency per se has been associated with an increase in both morbidity and mortality, particularly due to cardiovascular disease, which is an important risk factor for COVID-19 disease s

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Williams, James D., Oleh Slupchinskij, Anthony P. Sclafani, and Claude Douge. "Evaluation and Management of the Lingual Thyroid Gland." Annals of Otology, Rhinology & Laryngology 105, no. 4 (1996): 312–16. http://dx.doi.org/10.1177/000348949610500414.

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Lingual thyroid gland is a rare clinical entity that is due to failure of descent of the gland anlage early in the course of embryogenesis. It may present with symptoms of dysphagia, upper airway obstruction, or even hemorrhage at any time from infancy through adulthood. We present two illustrative cases of lingual thyroid gland along with a protocol for diagnosis and management of the condition. Elements in the diagnostic and therapeutic evaluation are described with attention to the clinical findings, laboratory tests, and radiographic imaging studies employed in confirming the diagnosis and

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Younes, Younes R., and Benjamin C. T. Field. "Survey of Practice: The Current Extent of Adjunctive Use of Lithium in the UK During Radioactive Iodine Therapy for Hyperthyroidism." Journal of the Endocrine Society 5, Supplement_1 (2021): A843—A844. http://dx.doi.org/10.1210/jendso/bvab048.1721.

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Abstract Background: The latest United Kingdom National Institute for Health and Care Excellence (NICE) guideline recommends 131I as first-line definitive treatment for Graves’ disease in patients who are unlikely to achieve remission with antithyroid medication. A small but significant proportion of patients have recurrence of hyperthyroidism after 131I therapy. Lithium enhances thyroidal iodine retention and thus increases radiation dose delivered to the thyroid gland during 131I therapy. While clinical trial findings with adjuvant Lithium have not been universally positive, several studies

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Shurpyak, S. O. "The substantiation of differentiated therapy of the combined disgormonal pathology of reproductive organs in women of reproductive age with comorbid conditions." Reproductive health of woman, no. 4 (August 17, 2022): 30–37. http://dx.doi.org/10.30841/2708-8731.4.2022.262768.

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The objective: substantiation of differentiated therapeutic approaches to the treatment of combined dyshormonal pathology of the reproductive organs, taking into account the comorbidity of patients.Materials and methods. 300 women of reproductive age (20–42 years, mean age – 29.9±5.6 years) with dyshormonal pathology of reproductive organs were examined: the main group included 180 patients who were prescribed complex differentiated pharmacotherapy for the treatment of combined dyshormonal pathology of the reproductive organs with correction of comorbid conditions, and the comparison group inc

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Hönes, Georg Sebastian, Ramona Gowry Sivakumar, Christoph Hoppe, Jörg König, Dagmar Führer, and Lars Christian Moeller. "Cell-Specific Transport and Thyroid Hormone Receptor Isoform Selectivity Account for Hepatocyte-Targeted Thyromimetic Action of MGL-3196." International Journal of Molecular Sciences 23, no. 22 (2022): 13714. http://dx.doi.org/10.3390/ijms232213714.

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Thyroid hormones (THs) and TH receptor-beta (TRβ) reduce hepatic triglycerides, indicating a therapeutic potential for TH analogs in liver steatosis. To avoid adverse extrahepatic, especially TRα-mediated effects such as tachycardia and bone loss, TH analogs with combined TRβ and hepatocyte specificity are desired. MGL-3196 is a new TH analog that supposedly meets these criteria. Here, we characterize the thyromimetic potential of MGL-3196 in cell-based assays and address its cellular uptake requirements. We studied the contribution of liver-specific organic anion transporters (OATP)1B1 and 1B

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