Relevant bibliographies by topics / Thyroid; TSH

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'Thyroid; TSH'

Author: Grafiati
Published: 5 June 2025
Last updated: 25 June 2025

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Journal articles on the topic "Thyroid; TSH"

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Thornes, H. M., D. T. McLeod, and D. Carr. "Economy and efficiency in routine thyroid-function testing: use of a sensitive immunoradiometric assay for thyrotropin in a general hospital laboratory." Clinical Chemistry 33, no. 9 (1987): 1635–38. http://dx.doi.org/10.1093/clinchem/33.9.1635.

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Abstract We measured thyrotropin (TSH) with a sensitive immunoradiometric assay (IRMA) in 2329 consecutive serum samples received for thyroid-function tests from hospital and general practice. Of these, 185 (7.9%) had TSH values less than 0.2 milli-int. unit/L: 33 (1.4%) were hyperthyroid, 20 (0.9%) were being treated for hyperthyroidism, 115 (4.9%) were receiving L-thyroxin, and 17 (0.7%) were clinically euthyroid but had severe non-thyroidal illnesses. In the first 506 serum samples, we also measured free thyroxin, free triiodothyronine (FT3), and total thyroxin. Thyroliberin (thyrotropin-releasing hormone, TRH) tests performed on 84 patients showed that an undetectable initial TSH (usually ascribable to therapy with thyroxin) predicted a flat TRH response. All untreated thyrotoxic patients had undetectable TSH. Experience confirmed that this TSH assay, in conjunction with a supplementary assay of FT3 when the TSH concentration is less than twice the limit of detection, is efficient and economical for routine evaluation of thyroid function in an unselected population.
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Lee, H. Y., A. E. Pekary, V. P. Smith, J. Sladek, and J. M. Hershman. "Immunoenzymatic quantification of low concentrations of thyrotropin." Clinical Chemistry 33, no. 7 (1987): 1223–26. http://dx.doi.org/10.1093/clinchem/33.7.1223.

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Abstract We evaluated an immunoenzymatic assay (Abbott HTSH EIA) for thyrotropin (TSH) as a tool for detecting hyperthyroidism and for monitoring thyroid hormone suppressive therapy in patients with nodular goiter, thyroid carcinoma, and hypopituitarism. We also tested with thyroliberin (TRH), to determine the correlation between peak and basal TSH in suppressed patients. For comparison, we used a nonequilibrium radioimmunoassay optimized for maximum sensitivity (J Clin Endocrinol Metab 1975;41:676). Hyperthyroid patients with values for either or both triiodothyronine and thyroxin above the normal reference interval had Abbott assay values less than or equal to 0.2 milli-int. unit/L, clearly below the Abbott assay normal range, as determined in 116 euthyroid subjects. We detected one-third of the suppressed patients (greater than or equal to 0.3 milli-int. unit/L) with RIA, 69% with the Abbott assay (TSH greater than or equal to 0.04 milli-int. unit/L). Only 20% of patients with undetectable basal TSH values in the Abbott assay responded to TRH with a detectable peak TSH value; the peak TSH value after TRH was proportional to the basal TSH value. A single basal TSH measurement by the Abbott HTSH EIA should be adequate for monitoring the degree of thyroidal suppression in thyroid-hormone-treated patients.
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Ortiga‐Carvalho, Tania M., Maria I. Chiamolera, Carmen C. Pazos‐Moura, and Fredric E. Wondisford. "Hypothalamus‐Pituitary‐Thyroid Axis." Comprehensive Physiology 6, no. 3 (2016): 1387–428. https://doi.org/10.1002/j.2040-4603.2016.tb00708.x.

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ABSTRACTThe hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone (TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the synthesis and secretion of pituitary thyrotropin (thyroid‐stimulating hormone, TSH), which acts at the thyroid to stimulate all steps of TH biosynthesis and secretion. The THs thyroxine (T4) and triiodothyronine (T3) control the secretion of TRH and TSH by negative feedback to maintain physiological levels of the main hormones of the HPT axis. Reduction of circulating TH levels due to primary thyroid failure results in increased TRH and TSH production, whereas the opposite occurs when circulating THs are in excess. Other neural, humoral, and local factors modulate the HPT axis and, in specific situations, determine alterations in the physiological function of the axis. The roles of THs are vital to nervous system development, linear growth, energetic metabolism, and thermogenesis. THs also regulate the hepatic metabolism of nutrients, fluid balance and the cardiovascular system. In cells, TH actions are mediated mainly by nuclear TH receptors (210), which modify gene expression. T3 is the preferred ligand of THR, whereas T4, the serum concentration of which is 100‐fold higher than that of T3, undergoes extra‐thyroidal conversion to T3. This conversion is catalyzed by 5′‐deiodinases (D1 and D2), which are TH‐activating enzymes. T4 can also be inactivated by conversion to reverse T3, which has very low affinity for THR, by 5‐deiodinase (D3). The regulation of deiodinases, particularly D2, and TH transporters at the cell membrane control T3 availability, which is fundamental for TH action. © 2016 American Physiological Society. Compr Physiol 6:1387‐1428, 2016.
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Beck-Peccoz, Paolo, and Luca Persani. "Variable biological activity of thyroid-stimulating hormone." European Journal of Endocrinology 131, no. 4 (1994): 331–40. http://dx.doi.org/10.1530/eje.0.1310331.

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Beck-Peccoz P, Persani L. Variable biological activity of thyroid-stimulating hormone. Eur J Endocrinol 1994;131:331–40. ISSN 0804–4643 Thyroid-stimulating hormone (TSH), like the other pituitary glycoprotein hormones, is produced and secreted as a mixture of isoforms, the majority of which represent differences in oligosaccharide structure and possess different bioactivity. When samples are quantified simultaneously by immunometric assay and bioassay, the ratio between bioactivity (B) and immunoreactivity (I) may serve as an index of the overall potency of TSH. Variations of the TSH B/I ratio have been documented in both physiological and pathological conditions associated with alteration of the two most important mechanisms controlling TSH synthesis and secretion, i.e. TRH release and the thyroid hormone feedback system. Major examples of this assumption are the low TSH bioactivity found in samples from patients lacking TRH and thus bearing a hypothalamic hypothyroidism, and the enhanced bioactivity that is invariably found in TSH from patients with thyroid hormone resistance. Moreover, variations of TSH bioactivity have been recorded in normal subjects during the nocturnal TSH surge, in normal fetuses during the last trimester of pregnancy, in patients with primary hypothyroidism and in patients with TSH-secreting pituitary adenoma and non-thyroidal illness. In conclusion, the secretion of TSH molecules with altered bioactivity plays an important pathogenetic role in various thyroid disorders, while in some particular physiological conditions the bioactivity of TSH may vary in order to adjust thyroid hormone secretion to temporary needs. Paolo Beck-Peccoz, Istituto di Scienze Endocrine, Ospedale Maggiore IRCCS, Via F. Sforza 35, 1-20122 Milano, Italy
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Wiersinga, W. M., E. Endert, M. D. Trip, and N. Verhaest-de Jong. "Immunoradiometric assay of thyrotropin in plasma: its value in predicting response to thyroliberin stimulation and assessing thyroid function in amiodarone-treated patients." Clinical Chemistry 32, no. 3 (1986): 433–36. http://dx.doi.org/10.1093/clinchem/32.3.433.

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Abstract We measured thyrotropin in plasma by an ultrasensitive immunoradiometric assay (TSH-IRMA, "Sucrosep," Boots-Celltech), before and after thyroliberin (TRH) stimulation, in 71 patients with suspected thyroid-function disorders. Thirty-three were taking amiodarone; none was receiving (anti)thyroid drugs. The patients were divided into four groups, according to their TSH response to TRH (as measured previously by conventional TSH-RIA) and the concentrations of thyroxin (T4) and triiodothyronine (T3) in their plasma. Observed ranges of plasma TSH-IRMA (milli-int. units/L) before and after TRH were: euthyroid (n = 20), 0.2-3.0 and 1.7-15.5; subclinically hypothyroid (n = 14), 4.3-18.5 and 20-75; hyperthyroid (n = 17), less than 0.09 and less than 0.09-0.4; and subclinically hyperthyroid (n = 20), less than 0.09-1.1 and less than 0.09-2.6. Evidently TSH-IRMA results for a single sample completely distinguish hyperthyroidism from euthyroidism. However, TSH-IRMA values may also be undetectable in subclinical hyperthyroidism. The TSH response to TRH can be predicted from basal TSH-IRMA results less than 0.09 or greater than or equal to 0.8 milli-int. unit/L, intermediate values can be associated with either a normal TSH response (euthyroidism) or a decreased TSH response (subclinical hyperthyroidism only). We advocate TSH-IRMA as the first diagnostic test of thyroid function for amiodarone-treated patients.
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Derkach, Kira V., Alena S. Pechalnova, Viktor N. Sorokoumov, et al. "Effect of a Low-Molecular-Weight Allosteric Agonist of the Thyroid-Stimulating Hormone Receptor on Basal and Thyroliberin-Stimulated Activity of Thyroid System in Diabetic Rats." International Journal of Molecular Sciences 26, no. 2 (2025): 703. https://doi.org/10.3390/ijms26020703.

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The approaches to correct thyroid deficiency include replacement therapy with thyroid hormones (THs), but such therapy causes a number of side effects. A possible alternative is thyroid-stimulating hormone (TSH) receptor activators, including allosteric agonists. The aim of this work was to study the effect of ethyl-2-(4-(4-(5-amino-6-(tert-butylcarbamoyl)-2-(methylthio)thieno[2,3-d]pyrimidin-4-yl)phenyl)-1H-1,2,3-triazol-1-yl) acetate (TPY3m), a TSH receptor allosteric agonist developed by us, on basal and thyroliberin (TRH)-stimulated TH levels and the hypothalamic-pituitary-thyroid (HPT) axis in male rats with high-fat diet/low-dose streptozotocin-induced type 2 diabetes mellitus (T2DM). Single and three-day administration of TPY3m (i.p., 20 mg/kg) was studied, and the effect of TPY3m on the HPT axis was compared with that of levothyroxine. TPY3m increased TH levels when administered to both healthy and diabetic rats, normalizing thyroxine and triiodothyronine levels in T2DM and, unlike levothyroxine, without negatively affecting TSH levels or the expression of hypothalamic and pituitary genes responsible for TSH production. TPY3m pretreatment preserved the stimulatory effects of TRH on TH levels and thyroid gene expression. This indicates the absence of competition between TPY3m and endogenous TSH for TSH receptor activation and is supported by our in vitro results on TPY3m- and TSH-stimulated adenylate cyclase activity in rat thyroid membranes. Morphological analysis of thyroid glands in diabetic rats after three-day TPY3m administration shows an increase in its functional activity without destructive changes. To summarize, TPY3m, with the activity of a partial allosteric agonist of the TSH receptor, was created as a prototype of drugs to correct thyroid insufficiency in T2DM.
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Yu, Anthony A., Robert J. Kemppainen, and John M. MacDonald. "Effect of endotoxin on hormonal responses to thyrotropin and thyrotropin-releasing hormone in dogs." American Journal of Veterinary Research 59, no. 2 (1998): 186–91. http://dx.doi.org/10.2460/ajvr.1998.59.02.186.

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SUMMARY Objective To determine whether administration of endotoxin affects thyroid gland function in dogs. Animals 24 Beagles. Procedure Dogs were given thyrotropin (TSH) or thyrotropin-releasing hormone (TRH) on 2 occasions. Twenty-four hours before the second challenge with TSH or TRH, all dogs were given 5 μg of endotoxin/kg of body weight. Serum concentrations of thyroxine (T4), free T4 (fT4), 3,3′,5-triiodothyronine (T3), reverse T3, autoantibodies to T3, and plasma concentrations of ACTH and cortisol were determined. Results Treatment with endotoxin was associated with reduced baseline concentration of serum T3 and increased baseline concentration of reverse T3 and free T4. Endotoxin treatment resulted in reduced peak serum concentration of T4 after TSH and TRH. However, peak serum concentration of fT4 after TSH and TRH were not affected by endotoxin. Conclusions A single dose of endotoxin affects several aspects of thyroid gland function in dogs, including T4 binding, deiodinase activity, and the thyroidal response to TSH and TRH. Clinical Relevance Acute or chronic nonthyroidal illness may affect thyroid gland function in dogs. Determination of fT4 concentration may provide a means of differentiating the effects of nonthyroidal illness from those of thyroid dysfunction, because endotoxin treatment was associated with increased baseline serum free T4 concentration and unchanged peak serum fT4 concentration after administration of TSH or TRH. (Am J Vet Res 1998;59:186–191)
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Iversen, E., and P. Laurberg. "Thyrotrophin-releasing hormone (TRH) and hormone secretion from the follicular and C-cells of perfused dog thyroid lobes." Acta Endocrinologica 109, no. 4 (1985): 499–504. http://dx.doi.org/10.1530/acta.0.1090499.

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Abstract. Recently we found small amounts of TRH immunoreactivity in the thyroid gland of dogs and pigs. In the present study we investigated if exogenous TRH influences the release of T4, T3 and cAMP from the follicular cells, and calcitonin and somatostatin from the C-cells of perfused dog thyroid lobes. 10−5 mol/l TRH inhibited the TSH induced iodothyronine and cAMP release from the thyroid while 10−8 mol/l TRH had no effect. The relative proportions of T4 and T3 in thyroid secretion were not altered by TRH infusion. TRH did not influence the basal or the Ca++ induced release of somatostatin and calcitonin. Hence TRH has a direct inhibitory effect on the hormone secretion from thyroidal follicular cells. This opens the possibility that TRH in the thyroid participate in the regulation of thyroid hormone secretion. Even though the concentration of TRH found to be effective is high our results may indicate that TRH in the thyroid participates in the regulation of thyroid hormone secretion as an antagonist to TSH.
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Djurica, Snezana, Miroljub Petrovic, Miodrag Rajic, Mladen Davidovic, and Dragoslav Milosevic. "Clinical implications of biochemical alterations induced by hypothalamic thyrotrophin hormone in elderly people." Jugoslovenska medicinska biohemija 22, no. 3 (2003): 243–48. http://dx.doi.org/10.2298/jmh0303243d.

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Thyrotrophin releasing hormone (TRH) test has been done in 62 subjects (females, average age 72), in order to analyze the stimulated TSH action, to assess the immediate thyroid reserve and to make the rational parameters of the thyroid function in the elderly. It was concluded that biochemical alterations provoked by application of hypothalamic thyrothropin hormone are very complex, but important for the clinical practice, giving the possibility of assessment of the actual state of the thyroid's function. It is also concluded that the estimation of TRH stimulated TSH in 20th and 60th minute, and T3 and FT4 in 60th minute of the TRH test provides very solid and rational method of thyroid function estimation, as well as the estimation of the thyroid reserve.
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Chiamolera, Maria Izabel, and Fredric E. Wondisford. "Thyrotropin-Releasing Hormone and the Thyroid Hormone Feedback Mechanism." Endocrinology 150, no. 3 (2009): 1091–96. http://dx.doi.org/10.1210/en.2008-1795.

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Thyroid hormone (TH) plays a critical role in development, growth, and cellular metabolism. TH production is controlled by a complex mechanism of positive and negative regulation. Hypothalamic TSH-releasing hormone (TRH) stimulates TSH secretion from the anterior pituitary. TSH then initiates TH synthesis and release from the thyroid gland. The synthesis of TRH and TSH subunit genes is inhibited at the transcriptional level by TH, which also inhibits posttranslational modification and release of TSH. Although opposing TRH and TH inputs regulate the hypothalamic-pituitary-thyroid axis, TH negative feedback at the pituitary was thought to be the primary regulator of serum TSH levels. However, study of transgenic animals showed an unexpected, dominant role for TRH in regulating the hypothalamic-pituitary-thyroid axis and an unanticipated involvement of the thyroid hormone receptor ligand-dependent activation function (AF-2) domain in TH negative regulation. These results are summarized in the review. The thyrotropin-releasing hormone neuron is well-positioned to integrate information about the environment as well as circulating TH levels and ultimately affect metabolism in response to these physiological changes.
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Dissertations / Theses on the topic "Thyroid; TSH"

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Song, Yue. "Study of membrane-related effects of TSH in thyrocytes: TSH receptor localization and action, and Duox-TPO interaction." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210241.

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1. Sphingolipid-cholesterol domains (lipid rafts) in normal human and dog thyroid follicular cells are not involved in thyrotropin receptor signalling. <p>Thyroid hormone regulates growth and development throughout the animal kingdom. The thyroid which secretes it, is controlled by TSH and its receptor TSHR. TSH and its receptor TSHR act through TSHR-coupled G proteins to control thyroid functions, with a stronger coupling of the TSHR with Gs protein than with Gq protein in human thyrocytes. Gq is not activated by TSH/TSHR in dog, whereas dog TSHR activates it in CHO transfected cells. To better understand TSHR and its downstream effectors G proteins, we attempted to answer the questions by the role of “lipid rafts/caveolae” in TSH action.<p>Lipid rafts/caveolae are sphingolipids-cholesterol-enriched microdomains on plasma membrane that have been proposed to play a role in signal transduction. By concentrating the signal molecules, lipid rafts/caveolae increase the efficiency of the interactions between the molecules and sequestrate them from the bulk membranes. The compartmentation of signal proteins in lipid rafts/caveolae might provide a possible explanation for the relationship between TSHR and G proteins in human and dog thyroctyes.<p>To answer these questions, we first tested the existence of such lipid microdomains in human and dog thyrocytes. By northernblot and RT-PCR of caveolin-1 mRNA, we demonstrated its existence in thyrocytes. The immunohistochemistry of caveolin-1 showed that caveolin/caveolae are present on the apical membrane of thyrocytes, opposite to the TSHR localization on the basolateral membranes. The isolation of lipid rafts/caveolae by Triton X-100/OptiPrep density experiments showed that TSHR and Gq are not in the rafts, even though other proteins such as insulin receptor, flotillin-2 and partially Gs are present in these lipid domains, as expected. Testing the function of the TSH receptor on its main cascade (Gs-Adenylyl cyclase-cAMP) after treating the follicles with Methyl β-cyclodextrin (a cholesterol chelator), we observed no modification of the cAMP levels by this treatment. This is in agreement with our conclusion that the TSHR-Gs-cAMP pathway does not involve the lipid rafts/caveolae domain.<p>TSH-activated signalling does not take place in these membrane domains. Therefore, the differences between species, concerning the TSHR-G proteins coupling cannot be explained by the presence of these membrane domains.<p>2. Species specific thyroid signal transduction: conserved physiology, diverged mechanisms<p>As mentioned above, Gq proteins are activated in human but not in dog thyroid, in response to TSHR. However the dog TSH receptor is able to activate Gq, as demonstrated in transfected CHO cells. Thus, different thyroid signal transduction pathways exist in different species. <p>In this study, we investigated the effects of TSH on its two signal transduction cascades, the cAMP pathway and the phospholipase C – IP3 – DAG pathway, as measured by cAMP levels and inositol phosphate generation. We also measured the effects of TSH and of agents stimulating specifically one of these cascades, forskolin for the cAMP pathway and Ca++ ionophore (ionomycin) and phorbolmyristate ester (TPA) for the phospholipase C pathway, on markers of thyroid hormone synthesis (H2O2 generation and iodide binding to proteins) and on thyroid hormone secretion in vitro in the various thyroids. <p>We demonstrated that in all species investigated, the TSH receptor activates both hormone synthesis and secretion. While in some species, including humans, rats and mice, the TSH receptor activates both the cAMP and phospholipase C– IP3 – DAG cascades, in others (e.g. dog) it only stimulates the first. The cAMP pathway activates the limiting step in thyroid hormone synthesis, the generation of H2O2, in dog, rat and mice but not in human, pig, horse and beef. Thus physiology remains but the pathways to achieve it differ. On a practical point of view, these results allow to choose adequate animal models for investigating different aspects of human thyroid signalling.<p><p>3. Duoxes -TPO association and its regulation in human thyrocytes: the thyroxisome<p>Duox (Dual Oxidase) and TPO (thyroid peroxidase) are the crucial enzymes for the thyroid hormones biosynthesis (T3/T4). TPO uses the hydrogen peroxide (H2O2) produced by Duox1 and Duox2 isoenzymes to covalently link oxidized iodide to tyrosines of thyroglobulin and couple the iodinated tyrosines to form triiodothyronine (T3) and thyroxine (T4). An excess of H2O2 is considered to be toxic for cells although at appropriate concentrations H2O2 may carry out signalling functions. Even though thyrocytes show a better resistance to H2O2 than other cells, it would be beneficial for thyrocytes if Duox and TPO localize closely to increase the working efficiency and avoid an excessive H2O2 spillage. In this study, we explored the association of Duox with TPO, and the possible factors affecting their interaction in the human thyrocyte model. This association was established by co-immunoprecipitation approaches on purified plasma membranes from human thyrocytes and COS-7 transfected cells. <p>Our results show that 1) Duox and TPO localize closely at the plasma membranes of human thyrocytes, 2) this association is up-regulated through the Gq-PLC-Ca2+-PKC pathway and down-regulated through the Gs-cAMP-PKA pathway. 3) H2O2 directly increases the association of Duox and TPO. 4) Partial NH2- or COOH-terminal Duox1 and Duox2 proteins show different binding abilities with TPO in COS-7 transfected cells.<p>The association of the two proteins Duox and TPO thus supports our previous hypothesis of the thyroxisome, a pluriprotein plasma membrane complex in which elements of the iodination apparatus localize closely, thus optimizing working efficiency and minimizing H2O2 spillage. Defect in this association, independently of the catalytic efficiency of the enzyme, could therefore impair thyroid hormone synthesis and be harmful to thyroid cells, leading to thyroid insufficiency.<p><br>Doctorat en Sciences biomédicales et pharmaceutiques<br>info:eu-repo/semantics/nonPublished
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Lee, Kok-Onn. "The biological activity of TSH (Thyrotropin)." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335319.

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Larsen, Donald A. "Quantification and regulation of thyroid stimulating hormone (TSH) and TSH messenger RNA in salmon /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/5343.

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Devlin, Marni Allison. "The characterization of TSH-mediated phospholipase D activity in thyroid cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0017/MQ47020.pdf.

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Typlt, Eva. "„Heiße“ Schilddrüsenknoten bei Kindern: Mutationshäufigkeiten und Mutationsmuster aktivierender TSH-Rezeptor- und Gs alpha- Mutationen." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-196346.

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Szintigrafisch heiße Schilddrüsenknoten (HTNs) bei Kindern sind selten. Ihre Malignitätsrate wird als höher beschrieben im Vergleich zu der Erwachsenenpopulation. Es wurden in dieser Dissertation klinische und molekulare Daten von 33 Kindern (29 benigne und 4 maligne HTNs) untersucht. In 17 der 29 benignen HTNs (59%) konnte eine TSHR- Mutation nachgewiesen werden. Die häufigste Mutation war die M453T (8 von 29 Proben). T632I- und D633Y- Mutationen konnten jeweils in zwei Fällen detektiert werden. Alle anderen gefundenen TSHR- Mutation wurden jeweils nur in einer Probe festgestellt, inklusive die neu aufgetretene Mutation A538T. Eine NRAS- Mutation wurde in einem HTN mit einer M453T- Mutation gemeinsam nachgewiesen. Ein PAX8/PPARγ- Rearrangement konnte in einem malignen Knoten (follikuläre Variante eines papillären Schilddrüsenkarzinoms; fvPTC) detektiert werden. Ebenfalls konnte in einem malignen HTN (papilläres Schilddrüsenkarzinom; PTC) eine T632I- Mutation nachgewiesen werden. Der Prozentsatz an TSHR- mutations-positiven HTNs in Kindern und Heranwachsenden lag in dem bei Erwachsenen beschriebenen Bereich. Auffällig war die signifikante Häufung der M453T- Mutation in der Kinderpopulation. Die beschriebene erhöhte Malignitätsrate der HTNs bei Kindern scheint nicht mit RAS- , BRAF- , RET/PTC- oder PAX8/PPARγ- Mutationen assoziiert zu sein.
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Johnsen, Hanna. "The Importance of the TSHR-gene in Domestic Chicken." Thesis, Linköpings universitet, Biologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-103687.

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Thyroid hormones are known to be important in several processes in chicken, such as growth, metabolism and reproductive system. In previous studies the thyroid stimulating hormone receptor (TSHR)-gene has been identified as a target for a selective sweep in commercial breeds of chicken such as broiler and White Leghorn. The evolution of domesticated species can be split into three periods. The first is the natural selection in their natural habitat, the second the beginning of the domestication process, when humans started to tame and breed the wild animals and the third is when animals were bred for commercial interests such as egg laying properties and meat production in chicken. Landraces, which are domesticated but not commercially bred races, are a great resource for identifying during which period a specific gene, which differs between wild type and commercial bred breeds, were selected. In this study Swedish landrace chickens were used in order to analyze the importance of a mutation in the TSHR-gene in the domestication process. The results of this study gave that all, except two individuals from the Bohuslän-Dals svarthöna were homozygous for the mutation known from commercial breeds. The two individuals from Bohuslän-Dals svarthöna were both heterozygous for the mutation. These results suggest that the TSHR mutation is important for the domestication process and were already more or less fixed at the commencement of commercial breeding. The mutation is thought to be dominant and to have an inhibitory impact on the TSHR activity. This might result in hypothyroidism which would make alterations in the reproductive system. This is plausible because the constant availability of food in captivity makes the seasonal reproductive system no longer critical for survival of progeny.
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Esapa, Christopher Tarh. "Mutation analysis of the TSH receptor, GTP-binding proteins and protein kinase A in thyroid disease." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322665.

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DAMIANI, RENATA. "Expressao estavel de tireotrofina humana (r-hTSH) em celulas de mamifero (CHO) que expressam 'alfa'2,6-sialiltransferase." reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9436.

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Made available in DSpace on 2014-10-09T12:26:48Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:06:19Z (GMT). No. of bitstreams: 0<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Durand, Jason AJ. "Regulation of Adipocyte Lipolysis by TSH and its Role in Macrophage Inflammation." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22694.

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Elevated Thyroid-Stimulating Hormone (TSH) is associated with an increased risk of cardiovascular disease (CVD). We hypothesized that TSH-stimulated FA release from adipocytes contributes to macrophage inflammation. 3T3-L1 and human subcutaneous differentiated adipocytes were treated with TSH for 4 hours under various conditions and lipolysis assessed via glycerol secretion. Optimal conditions were determined and protein expression of ATGL, HSL and perilipin remained stable. TSH-stimulated 3T3-L1 or human adipocyte-conditioned medium (T-ACM) was placed on murine J774 or human THP-1 macrophages, respectively, and macrophage cytokine mRNA levels (IL-1β, IL-6, MCP-1, and TNFα) were measured by real-time RT-PCR. T-ACM did not change cytokine mRNA expression in J774 macrophages or THP-1 macrophages when compared to ACM. Absence of BSA in the medium may have hindered release of FA from differentiated adipocytes into the medium, BSA may be required to permit adequate FA accumulation in the medium to then evaluate the effect of T-ACM on macrophages. Further investigation is required to determine the effect of FA on J774 and THP-1 inflammatory response.
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Cristo, Ana Patrícia de. "Avaliação do TSH sérico como fator preditivo de malignidade em nódulos tireoidianos de pacientes submetidos à punção aspirativa por agulha fina." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/71619.

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Nódulos de tireoide são achados clínicos comuns e, atualmente, o método diagnóstico de escolha para diferenciar lesões benignas de lesões malignas é a análise citopatológica dos nódulos através de punção aspirativa por agulha fina (PAAF). Estudos prévios já indicaram que os níveis séricos de TSH podem estar associados ao risco de malignidade nodular. O objetivo deste estudo foi avaliar se o TSH sérico é um preditor de malignidade em nódulos de tireoide em pacientes submetidos à PAAF. A amostra contemplou 100 indivíduos puncionados consecutivamente no Centro de Pronto Diagnóstico Ambulatorial, CPDA, HCPA e que apresentavam níveis de TSH dentro da normalidade. Todos os pacientes foram submetidos à PAAF da tireoide com controle ultrassonográfico e tiveram, posteriormente, a análise citopatológica da PAAF e a avaliação histopatológica do bloco celular. A análise estatística baseou-se em dados de frequências e testes não-paramétricos foram utilizados para correlacionar as variáveis. A população de estudo foi composta por 100 pacientes, sendo 89 mulheres e 11 homens. A média de idade foi de 54,1 ± 14,2 anos e o tamanho médio dos nódulos foi de 2.53 ± 1.36 centímetros. Vinte e seis % destes pacientes apresentavam algum tipo de doença tireoidiana prévia. A média do nível de TSH sérico entre os 100 indivíduos foi de 1.81 ± 1.08 uUI/mL. De acordo com o diagnóstico citopatológico da PAAF complementado pelos achados do bloco celular foram classificados como malignos 8% dos nódulos, 70% benignos, 11% suspeitos/ indeterminados, 8% insuficientes e 3% lesões foliculares. A média de TSH para os grupos maligno, benigno, suspeito/indeterminado, insuficiente e lesão folicular foi de, respectivamente, 2.48, 1.59, 2.21, 2.35 e 2.20 uUI/ml (p>0.05). Não houve diferença estatística significante entre os grupos diagnósticos avaliados, apesar de haver uma variação entre os níveis de TSH entre os grupos refletindo, provavelmente, o pequeno tamanho da amostra.<br>Thyroid nodules are common and currently the first choice of investigation in distinguishing benign from malignant disease is the cytological analysis of fine needle aspiration biopsy (FNAB). Previous studies have indicated that serum TSH levels might be associated with the likelihood of malignancy. The aim of this study was to evaluate whether serum TSH is a predictor of malignancy of thyroid nodules in patients undergoing FNAB. One hundred consecutive patients, who underwent FNAB as part of clinical investigation of thyroid nodule in a multidisciplinary setting tertiary hospital, underwent ultrasonography followed by FNAB, cytology and cell block analysis. Independent-Samples Kruskal-Wallis test was used to compare the groups. The study population comprised of 89 female and 11 male patients. The mean age was 54.1 ± 14.2 years. 26% had previous thyroid disease. Mean TSH levels was 1.81 ± 1.08 uUI/mL and the mean nodule size was 2.53 ± 1.36cm. Final cytology/cell block diagnosis classified 8% as malignant, 70% as benign, 11% suspicious/indeterminate, 8% insufficient and 3% follicular lesion. The mean TSH values for malignant, benign, suspect, insufficient and follicular lesion group were as follows: 2.48, 1.59, 2.21, 2.35 and 2.20 uUI/ml, respectively. No statistical significance was detected between TSH levels and final cytology/cell block diagnosis, possibly reflecting the small sample size (P>0.05). We observed a variation between TSH levels among the groups covered in this study, but there was no statistically significant difference among them.
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Books on the topic "Thyroid; TSH"

1

Islam, Sabita. TSH regulation of thyroid function in cells in culture. University of Birmingham, 1995.

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G, Leb, ed. Thyrotropin: Ultrasensitive TSH measurement in clinical research and diagnostics. W. de Gruyter, 1987.

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Kutaiba, Tawfik Yousif. Zur Beurteilung der Bioäquivalenz von L-Thyroxin-Präparaten mittels der Serumkonzentrationen von TSH. [s.n.], 2001.

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Eber, O., G. Leb, A. Passath, and H. Höfler. Thyrotropin: Ultrasensitive THS Measurement in Clinical Research and Diagnostics. de Gruyter GmbH, Walter, 2019.

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Santé et Santé et Forme. Carnet de Suivi Thyroïde: Notez l'évolution de Votre Thyroïde - Convient Aux HYPERS et Aux HYPOS - Idéal Pour Observer et Conserver l'équilibre de Votre Thyroïde - Notez l'évolution de Votre TSH. Independently Published, 2020.

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Eisel, Gabriele. Der Vergleich der Bioverfügbarkeit von zwei Levo-Thyroxin-Natrium-Präparaten versus einer Referenzlösung in einer Doppelblindstudie, Auswirkung auf den TSH-Serumspiegel bei weiblichen Probanden. 2000.

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Book chapters on the topic "Thyroid; TSH"

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Beck-Peccoz, Paolo, and Giovanni Faglia. "TSH-Secreting Pituitary Adenomas." In Thyroid Diseases. CRC Press, 2024. https://doi.org/10.1201/9781003574293-11.

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Scanlon, M. F. "Control of TRH and TSH Secretion." In Pharmacotherapeutics of the Thyroid Gland. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60709-7_2.

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Misrahi, M., and E. Milgrom. "The TSH Receptor." In Pharmacotherapeutics of the Thyroid Gland. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60709-7_3.

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Hale, P. M., M. Liebert, N. J. Hopwood, and J. C. Sisson. "TSH Receptor Antibodies in Neonatal Hyperthyroidism." In Thyroid Autoimmunity. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-0945-1_69.

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Colao, Annamaria, and Claudia Pivonello. "Thyroid-Stimulating Hormone (TSH)." In Encyclopedia of Pathology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-28845-1_5121-1.

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Colao, Annamaria, and Claudia Pivonello. "Thyroid-Stimulating Hormone (TSH)." In Endocrine Pathology. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-62345-6_5121.

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Munsakul, Natee, and Rebecca S. Bahn. "Adipogenesis and TSH Receptor Expression." In Thyroid Eye Disease. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1447-3_3.

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Fenzi, G. F., P. Vitti, C. Marcocci, L. Chiovato, and E. Macchia. "TSH Receptor Autoantibodies Affecting Thyroid Cell Function." In Thyroid Autoimmunity. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-0945-1_10.

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Chan, John, Michele De Luca, Pilar Santisteban, et al. "Nature of Thyroid Autoantigens: The TSH Receptor." In Thyroid Autoimmunity. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-0945-1_2.

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Goede, Simon Lucas, and Melvin Khee-Shing Leow. "Reference Ranges for TSH and FT4." In Thyroid Systems Engineering. River Publishers, 2022. http://dx.doi.org/10.1201/9781003339823-10.

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Conference papers on the topic "Thyroid; TSH"

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Mohammed, Areej, Hussam Alshraideh, and Abdulrahim Shamayleh. "A Predictive Model for TSH Levels Based on Thyroid Disorders Symptoms." In 2024 IEEE International Conference on Technology Management, Operations and Decisions (ICTMOD). IEEE, 2024. https://doi.org/10.1109/ictmod63116.2024.10959131.

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Mohammed, Areej, Hussam Alshraideh, and Abdulrahim Shamavleh. "A Predictive Model for TSH Levels Based on Thyroid Disorders Symptoms." In 2024 IEEE International Conference on Technology Management, Operations and Decisions (ICTMOD). IEEE, 2024. https://doi.org/10.1109/ictmod63116.2024.10878146.

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Ozaki, Bianca Chames, Paulo Cesar Zimmermann Felchner, Tatiane Mendes Boutin Bartneck Telles, et al. "Thyroid-stimulating hormone reference intervals in the first trimester in an iodine-sufficient population of pregnant women attended by the public health system in Curitiba, South of Brazil." In Resumos do 56º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2024. https://doi.org/10.5327/1516-3180.142s1.11154.

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Objective: Thyroid disorders are prevalent among women of reproductive age. Serum thyroid-stimulating hormone (TSH) concentration is the primary marker used to assess thyroid function during pregnancy. Changes in thyroid function during pregnancy can significantly affect a woman’s health, pregnancy outcomes, fetal health, and child development. When comparing TSH levels between pregnant and non-pregnant women, TSH levels are generally lower during pregnancy, particularly in the first trimester, with gradual increase during pregnancy. Therefore, this study aimed to determine the normal reference range of TSH during the first trimester of gestation in pregnant women from Curitiba. Method: This prospective cohort study included a sample of 225 pregnant women using the public health system in Curitiba, aged &gt;18 years old. After applying exclusion criteria (gestational age &gt;13 weeks, twin pregnancy, thyroid disease, and iodine ingestion), TSH levels were measured using a chemiluminescent immunoassay on Atellica IM, along with aTPO, FT4, and TT4 measurements. The 2.5, 50, and 97,5 TSH percentiles were estimated for the normal pregnant population. Conclusion: The mean gestational age was 8.6 weeks (SD 2.33). Of the participants, 22 (9.8%) were psitive for aTPO. After applying the exclusion criteria, the 2.5 and 97.5 percentiles of TSH were 0.12 and 5.28 μIU/mL, repectively. The iodine status of the population was sufficient. Higher TSH levels were observed in the aTPO-positive subgroup, and the proportion of positive aTPO was significantly higher in the group with TSH &gt;2.5 μIU/mL. The findings indicate that the TSH reference range in this population is higher than those reported in other regions, reinforcing the importance of avoiding the use of fixed TSH values from other populations when evaluating thyroid function during pregnancy. Compared to the laboratory reference values for non-pregnant individuals (0.48 to 5.60 μIU/mL), the American Thyroid Association’s recommended reduction of 0.5 μIU/mL in upper limit and 0.4 μIU/mL in the lower limit closely aligns with the values observed in this study.
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Yulianti, Kartika, Aris Wibudi, and Mila Citrawati. "Relation Between Tiroid Status with Glycemic Control of Type 2 DM Patients at RSPAD Gatot Soebroto." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.12.

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ABSTRACT Background: Diabetes Mellitus (DM) is a group of symptoms that arise due to increased blood sugar levels. Diabetes Mellitus type 2 has a higher risk of developing thyroid dysfunction. Thyroid dysfunction can affect various body metabolism and result in insulin resistance, significantly affecting glycemic control in DM patients. This study aimed to determine the relation between thyroid status as assessed by the level of thyroid-stimulating hormone (TSH), free thyroxine (FT4), and glycemic control (HbA1c). Subjects and Method: A cross-sectional study. A sample of 38 DM patients was selected by purposive sampling. The dependent variable was glycemic control. The independent variables were TSH and FT4. Patients were classified into 4 quartiles (Q) based on their TSH and FT4 levels. Statistic test used was non parametric for category group of variables, which was Chi square test. Results: Mean of fasting blood glucose was 200,56 mg/dL (modus 137 mg/dL), mean of 2 hours post prandial blood glucose was 247 mg/dL (modus 305 mg/dL). Subjetcs with poor glycemic control dominated as much as 76%. Most subjects had TSH level at Q4 (36%), while most of the subjects had FT4 level at Q1 (34%). The results showed that 38 samples with poor glycemic control were 72% in the 4th quartile (Q4) (&gt; 3.1750 mU / L) TSH, and 64.7% were in Q1 (≤ 11.8400) FT4. The analysis showed that there was a significant relation between TSH (p = 0.047) and FT4 (p = 0.041) with glycemic control in type 2 DM patients. Conclusion: FT4 and TSH levels relate to glycemic control in type 2 DM patients Keywords: TSH, FT4, HbA1c, Diabetes Mellitus Correspondence: Mila Citrawati. Department of Faal, Faculty of Medicine, UPN Veteran, Jakarta. Jl. RS Fatmawati, Pondok Labu, South Jakarta 12450, Telp. (021) 7656971. E-mail: milacitrawati@upnvj.ac.id. Mobile: 081282990515 DOI: https://doi.org/10.26911/the7thicph.05.12
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Poloni, José Antonio Tesser, Nairo Massakazu Sumita, Leonardo de Souza Vasconcellos, et al. "Brazilian External Quality Assessment Program for serum TSH and free T4: A report from 2007 to 2023." In Resumos do 56º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2024. https://doi.org/10.5327/1516-3180.142s1.10614.

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Objective: Thyroid hormone levels are crucial for assessing thyroid function and diagnosing dysfunction. External quality assessment programs (EQAP) aim to evaluate laboratory analytical capabilities, identify differences, and enhance overall quality. This study assessed the performance evolution of laboratories participating in an EQAP for thyroid hormones, managed by a Brazilian proficiency testing (PT) provider. Method: EQAPs for TSH and free T4 involved four surveys per year with three lyophilized human serum samples per survey. Data from 2007 to 2023 were analyzed, focusing on the number of participants, methods used, mean coefficient of variation (CV), and median CV for different testing methods. Conclusion: Regarding TSH, 1,101 laboratories contributed 90,288 datasets, with the mean CV decreasing from 7.9% in 2007 to 4.9% in 2023. Regarding free T4, 1,345 participants provided 121,922 datasets, with the mean CV decreasing from 7.6% in 2007 to 5.5% in 2023. This study revealed variations in CV across testing methodologies. Notably, EIA exhibited the highest CV for TSH, while both EIA and EF showed the highest CV for free T4. The consistent decline in CV over time underscores EQAPs in enhancing clinical laboratory standards. These findings underscore the importance of considering both the results and the testing method used by the laboratory when managing patients.
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Zasimova, E. Z., and A. S. Golderova. "THE EFFECT OF A LONG VOYAGE CONDITIONS ON THE LEVEL OF STRESS-IMPLEMENTING HORMONES IN RIVER TRANSPORT WORKERS." In The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-222-225.

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Abstract: The stress-releasing hormones in river workers before and after a long voyage in Yakutia have been evaluated. We revealed a significant increase in the level of thyroid hormones (TSH, T3, T4) and testosterone, as well as a decrease in cortisol and integral thyroid index, that is indicating stress, as well as signs of depletion of adaptive mechanisms.
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Dunga, Lucas Medeiros, Bruna Emanuelle Alves Pinto, Lucca Ferdinando Queiroz Fernandes, Matheus Araújo de Medeiros, and Bianca Etelvina Santos Oliveira. "Thyroid dysfunction with the continued use of beta interferon in the treatment of multiple sclerosis." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.691.

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Introduction: The treatment of multiple sclerosis (MS) with beta interferon has been shown to be effective in reducing the number of relapses and the inflammatory activity of the disease, as well as slowing its progression. Although there are controversies in the literature, recent studies have pointed to the possibility of thyroid dysfunction as a side effect of prolonged use of beta interferon. Objectives: To analyze the presence of thyroid dysfunction due to the use of beta-interferon in patients with multiple sclerosis. Methods: That is a documentary, observational, and analytical study, with a quantitative, retrospective, and cross-sectional approach. Sociodemographic variables, thyroid function laboratory tests, and medication usage time present in medical records were analyzed. Results: From 118 medical records evaluated, after applying the exclusion and inclusion criteria, 35 were included in the study. 80% of the sample were female, mean age was 32.43. The mean values for TSH and free T4 before starting treatment with beta-interferon were 1.66 mIU/L and 0.96 ng/dL, respectively. After 6 months, the values for TSH and free T4 were 2.20 mIU/L and 0.91 ng/dL, respectively. It can be concluded that the continuous use of beta-interferon did not lead to significant changes in TSH and free T4 levels compared to baseline (P = 0.061 and P = 0.102, respectively). It is worth noting that there were two cases of subclinical hypothyroidism developed during the study. Conclusion: MS patients using beta-interferon are mostly young women. No significant changes in their thyroid function were observed. Therefore, based on this information, the need for routine periodic laboratory tests to evaluate thyroid function in patients using beta-interferon is questioned. Further studies are needed with a larger sample size to definitively clarify this topic.
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Mohsen, Israa Harjan, and Raoof Jabbar Maaroof. "Evaluation of chlorine gas effects on thyroid hormone levels and liver enzymes among water purification station workers." In 24th International Scientific Conference Engineering for Rural Development. Latvia University of Life Sciences and Technologies, Faculty of Engineering and Information Technologies, 2025. https://doi.org/10.22616/erdev.2025.24.tf283.

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The goal of the research is to detect the effects of chlorine gas on thyroid hormone levels and liver enzymes among water purification station workers in Babylon governorate. Blood samples are taken from 70 persons working in the purification stations of water in Babylon governorate at various periods of work (1-20 years) compared with the control group (30 samples) who are healthy. Groups of workers are divided into 4 groups according to the work intervals in the station. Serum samples are used to detect thyroid hormones (TSH, T3, T4) and liver enzymes (AST, ALT). The results display a meaningful increase in the TSH levels in the employees for different intervals of work when compared to the control group and it shows more elevation with intervals increasing exposure to chlorine while the T3, T4 levels are decreased significantly for the different intervals of work relative to control and it increasingly falls with the intervals of exposure to chlorine. Yet, there were no significant differences in liver enzymes in the workers in comparison to the control group. Conclusion: workers who have been exposed for longer durations may be at higher risks for thyroid hormone imbalances, emphasizing the need for monitoring thyroid function in this population.
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Abduwahab Alheany, Aya R., and Ammer Abd. Mohammed. "Effect of Toxoplasmosis On Zinc and Thyroid Hormones Levels with Pregnant Women." In IX. International Scientific Congress of Pure, Applied and Technological Sciences. Rimar Academy, 2023. http://dx.doi.org/10.47832/minarcongress9-26.

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This study included 115 pregnant women, the case group consisted of 65 women who were infected with toxoplasmosis, while the control group involved 50 pregnant women who were not infected with toxoplasmosis. All the studied women attended Baghdad teaching hospital during the period from 1st February 2021 to 1st March 2022. The results in the current study revealed NS. between the mean ages between the case group (41.84±15.88) years and the control group (40.85±15.48) years. There was HS. (P&lt;0.01) in mean Toxoplasma IgM levels between the case group (2.00±1.17) and the control group (0.09±0.17), and there was also HS. (p&lt;0.01) in mean Toxoplasma IgG levels between the case group (14.20±7.06) and the control group (0.06±0.11). The findings showed HS. (p&lt;0.01) in serum zinc levels between the patients group (56.84±18.87) and the control group (88.09±14.85). The result also showed HS. (p&lt;0.01) between the mean levels of T3 and TSH (3.16±1.44) and (2.63±1.06) respectively and the control groups (1.37±0.80) and (1.14±0.98) respectively, while NS. (p&gt;0.05) was found between the levels of T4 (3.65±0.97) and the control group (4.02±1.60). There was a correlation between Toxoplasma IgM and serum zinc (22.515), T3 (4.753), T4 (9.261), and TSH (2.795) with HS. (P&lt;0.01), and a correlation between Toxoplasma IgG and serum zinc (17.505), T3 (11.736), T4 (11.377) and TSH (12.878) with HS. (P&lt;0.01)
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Younus DHANNOON, Azhar, and Abeer Ataallah Ayyed AL-HADIDY. "ESTIMATION OF SOME ADIPOSE TISSUE HORMONES (VISFATIN AND ADIPONECTIN) IN PATIENTS WITH HYPOTHYROIDISM." In V. International Scientific Congress of Pure, Applied and Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress5-22.

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Hypothyroidism is a medical state referring to the lack of secretion of thyroid hormones (THs) in the body. It occurs when the thyroid gland starts to produce and secrete a small amount of thyroid hormones Thyroxine (T4) and Triiodothyronin (T3), this will affect body cells, resulting in a slowing of the body's metabolic rate, weight gain, and tachycardia. Visfatin and adiponectin are two hormones from type adipokine produced from fat tissue. Those hormones have an important function in protein, lipid and glucose metabolism, as well their role in energy expenditure. Eighty cases of both sexes (male and female) have been collected from the hospitals and private laboratories of Iraq. They are divided into two groups. Group1 (control group) includes (40) healthy individuals and the group2 includes (40) hypothyroid patients, All patients and controls underwent history taking, determination of levels of visfatin, adiponectin, Thyroid-stimulating hormone (TSH), T4, T3 and lipid profile. The results showed that Visfatin levels in group 2 were significantly higher than in group1, on the other hand, Adiponectin levels decreased in group2 compared with the control group at probability (P≤ 0.01), and concerning the lipid profile, there was a significant increase in the levels of lipid parameters total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-c) and very low density lipoprotein (VLDL) while high density lipoprotein (HDL) was decreased in group2 compared to control group
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Reports on the topic "Thyroid; TSH"

1

Jiang, Yuchang, Mao Zhao, Zhipeng Fan, Zaili Gan, and Yong Jiang. Traditional Chinese Medicine for Primary hypothyroidism: A protocol for a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.3.0035.

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Review question / Objective: The purpose of this study was to analyze the effect of Traditional Chinese Medicine on Primary hypothyroidism, and to provide evidence for the treatment of Primary hypothyroidism with Traditional Chinese Medicine. Condition being studied: Primary hypothyroidism is a systemic hypometabolic syndrome in which TH deficiency or TH resistance is caused by the disease of the thyroid itself. TH replacement therapy, internationally recognized as the most effective treatment, has many disadvantages. Studies have shown that Traditional Chinese Medicine can effectively eliminate the symptoms of hypothyroidism and improve thyroid secretion. However, the validity of the results was low due to study limitations. Therefore, it is necessary to conduct a systematic analysis of randomized controlled trials of Traditional Chinese Medicine for Primary hypothyroidism.
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Koven, William, Gordon Grau, Benny Ron, and Tetsuya Hirano. Improving fry quality, survival and growth in commercially farmed fish by dietary stimulation of thyroid hormone production in premetamorphosing larvae. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7695856.bard.

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There is a direct correlation between successful metamorphosis from larvae to post-larvae and the quality of the resultant juveniles or fry. Juvenile quality, in turn, is a major factor influencing fish production level and market price. However, following the profound morphological and physiological changes occurring during metamorphosis, the emerging juveniles in some species characteristically demonstrate heterotrophic growth, poor pigmentation, cannibalism and generally poor survival. The white grouper (Epinephelus aeneus) in Israel and the Pacific threadfin (Polydactylussexfilis) in Hawaii are two promising candidates for mariculture that have high market value but a natural fishery that has sharply declined in recent years. Unfortunately, their potential for culture is severely hampered by variable metamorphic success limiting their production. The main objective was to compare the efficacy and economic viability of dietary or environmental iodine on metamorphic success and juvenile quality in the white grouper and the pink snapper which would lead to improved commercial rearing protocols and increased production of these species both in Israel and the US. The Hawaii Institute of Marine Biology encountered problems with the availability of pink snapper brood stock and larvae and changed to Pacific threadfin or moi which is rapidly becoming a premier aquaculture species in Hawaii and throughout the Indo-Pacific. The white grouper brood stock at the National Center for Mariculture was lost as a result of a viral outbreak following the sudden breakdown of the ozone purification system. In addition, the NCM suffered a devastating fire in the fall of 2007 that completely destroyed the hatchery and laboratory facilities although the BARD project samples were saved. Nevertheless, by studying alternate species a number of valuable findings and conclusions that can contribute to improved metamorphosis in commercially valuable marine species resulted from this collaborative effort. The Israeli group found that exposing white grouper larvae to external TH levels synchronized and increased the rate of metamorphosis. This suggested that sub-optimal synthesis of TH may be a major factor causing size heterogeneity in the larval population and high mortality through cannibalism by their larger more metamorphosed cohorts. Two protocols were developed to enrich the larvae with higher levels of the TH precursor, iodine; feeding iodine enriched Artemia or increasing the level of seawater iodine the larvae are exposed to. Results of accumulated iodine in gilthead seabream larvae indicated that the absorption of iodine from the water is markedly more efficient than feeding iodine enriched Artemia nauplii. Samples for TH, which will be analyzed shortly, will be able to determine if another dietary factor is lacking to effectively utilize surplus tissue iodine for TH synthesis. Moreover, these samples will also clarify which approach to enriching larvae with iodine, through the live food or exposure to iodine enriched seawater is the most efficient and cost effective. The American group found that moi larvae reared in ocean water, which possessed substantially higher iodine levels than those found in seawater well water, grew significantly larger, and showed increased survival compared with well water reared larvae. Larvae reared in ocean water also progressed more rapidly through developmental stages than those in low-iodine well seawater. In collaboration with Israeli counterparts, a highly specific and precise radioimmunoassay procedure for thyroid hormones and cortisol was developed. Taken altogether, the combined Hawaiian and Israeli collaborative research suggests that for teleost species of commercial value, adequate levels of environmental iodine are more determinate in metamorphosis than iodine levels in the live zooplankton food provided to the larvae. Insuring sufficiently high enough iodine in the ambient seawater offers a much more economical solution to improved metamorphosis than enriching the live food with costly liposomes incorporating iodine rich oils.
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