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Journal articles on the topic 'Thyrosine'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Ergün Barış, Kaya, and Şener Yusuf Ziya. "Hypertensive toxicity of thyrosine kinase inhibitors; Friend or Foe?" Annals of Clinical Hypertension 5, no. 1 (2021): 001–2. http://dx.doi.org/10.29328/journal.ach.1001025.

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Tyrosine kinase inhibitors (TKIs) are widely used in Oncology practice. Hypertension may develop during cancer treatment and TKIs are well known drugs that are associated with drug related hypertensive toxicity. TKI related hypertensive toxicity is not always the indicator of worse clinical outcomes and it may be the sign of treatment efficacy.

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2

Ponikwar, Walter, Peter Mayer та Wolfgang Beck. "Metallkomplexe mit biologisch wichtigen Liganden, CXLVI [1]. Bis(allyl)-N,O-α-Aminocarboxylat-Rhodium-Komplexe / Metal Complexes of Biologically Important Ligands, CXLVI [1]. Bis(allyl)-N,O-α-Aminocarboxylate-Rhodium Complexes". Zeitschrift für Naturforschung B 57, № 7 (2002): 810–18. http://dx.doi.org/10.1515/znb-2002-0714.

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The reactions of [(η3-C3H5)2Rh-μ-Cl]2 with the anions of α-amino acids (glycine, L-alanine, L-valine, L-isoleucine, L-proline, L-phenylalanine, L-phenylglycine, L-thyrosine) afford the N,O-chelates (η3-C3H5)2Rh(α-amino carboxylate). For complex (η3-C3H5)2Rh(glycinate) dynamic behaviour in solution could be observed by 1H NMR. The structure of (η3-C3H5)2Rh(L-prolinate) was determined by X-ray diffraction.

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3

Liao, Fei, Bo He, Ke-Jie Du, Shu-Qin Gao, Ge-Bo Wen, and Ying-Wu Lin. "Enhanced Dehaloperoxidase Activity of F43Y Myoglobin with a Novel Thyrosine–Heme Crosslink." Chemistry Letters 45, no. 9 (2016): 1087–89. http://dx.doi.org/10.1246/cl.160461.

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4

Solenov, E. I. "On the interaction of cytosolic complexes of the glucocorticoid receptor and synthetic glucocorticoid responsive element." Problems of Endocrinology 44, no. 3 (1998): 41–44. http://dx.doi.org/10.14341/probl199844341-44.

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The constant of affinity between glucocorticoid receptor (GR) complex isolated together with triamcinolone and a synthetic oligonucleotide glucocorticoid-responsive element (GRE) corresponding to the GRE-1 sequence of the rat thyrosine aminotransferase gene promoter is assessed. Singlestranded oligonucleotides with the straight sequence (Kd 0.2 ± 0.006 pM) possess the highest affinity for GR. The affinity of single-stranded oligonucleotides with antisense sequence is far lower (Kd 1.5 ± 0.2 pM), but is superior to that of double-stranded oligo GRE (Kd 12.0+ 1.1 pM). The results suggest that th

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5

Brisslert, M., L. Bian, M. Svensson, et al. "OP0176 S100a4 Regulates the Src-Thyrosine Kinase Dependent Differentiation of TH17 Cells in Rheumatoid Arthritis." Annals of the Rheumatic Diseases 73, Suppl 2 (2014): 129.1–129. http://dx.doi.org/10.1136/annrheumdis-2014-eular.5414.

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6

Lassau, N., S. Koscielny, L. Chami, et al. "Functional imaging by DCE-US as a surrogate for response in phase I/II of different targeted therapies by DCE-US: Which quantitative parameter and which timing." Journal of Clinical Oncology 25, no. 18_suppl (2007): 14093. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14093.

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14093 Background: The early evaluation of targeted treatments is a major challenge in oncology. Functional approaches based on the measure of tumoral vascularization have been developed using different modalities of imaging (CT, MRI, US). We analyzed the response of tumors in three studies using different targeted treatments with dynamic contrast enhanced-ultrasonography (DCE-US). Seven parameters characterizing tumor perfusion were estimated. The objective of the study was to determine which parameter is the most appropriate and when to use it to confirm earlier the efficacy of treatment. Met

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7

Månsson, Lisa, Carina Törn, and Mona Landin-Olsson. "Islet Cell Antibodies Represent Autoimmune Response Against Several Antigens." International Journal of Experimental Diabetes Research 2, no. 2 (2001): 85–90. http://dx.doi.org/10.1155/edr.2001.85.

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To study the antigens involved in the islet cell antibody (ICA) reaction we selected 30 patient serum samples (ten in each group) positive for ICA and one other additional autoantibody, such as glutamic acid decarboxylase antibodies (GADA), thyrosine phosphatase antibodies (IA-2A) or insulin autoantibodies (IAA). The serum samples were incubated with the specific antigen (GAD65, IA-2 or insulin) and the ICA analysis and the corresponding immunoprecipitation assay were performed before and after the absorption.We could then demonstrate that specific autoantibodies against GAD65 and IA-2 could b

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8

Elitsur, Yoram, Jeffrey A. Moshier, Julie Dosescu, Johnny Tureaud, and Adib P. N. Majumdar. "Diminution of pp60c-sarc Thyrosine Kinase in the Gastric Mucosa of Children With Helicobacter Pylori Gastritis. † 481." Pediatric Research 41 (April 1997): 83. http://dx.doi.org/10.1203/00006450-199704001-00501.

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9

Goncharov, N. P., N. I. Verbovaya, and T. P. Krivchenko. "The state of the sympathetic-adrenal system in patients with hypothalamic syndrome of puberty." Problems of Endocrinology 43, no. 4 (1997): 18–20. http://dx.doi.org/10.14341/probl199743418-20.

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Twenty-nine male patients with the hypothalamic syndrome of puberty and 13 healthy controls aged 15 to 23 were examined in order to elucidate the contribution of the sympathoadrenal system to the pathogenesis of arterial hypertension in this patient population. The sympathoadrenal activity was assessed from the level of dopamine, noradrenalin, and adrenalin in the blood plasma measured by high-pressure liquid chromatography using highly sensitive detectors. Adrenalin level was significantly decreased in the patients with arterial hypertension, probably because of suppression of phenylethanol m

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10

Miyaso, Hidenobu, Noriko Nakamura, Yoshiharu Matsuno, Yukiko Kawashiro, Masatoshi Komiyama, and Chisato Mori. "Postnatal exposure to low-dose decabromodiphenyl ether adversely affects mouse testes by increasing thyrosine phosphorylation level of cortactin." Journal of Toxicological Sciences 37, no. 5 (2012): 987–99. http://dx.doi.org/10.2131/jts.37.987.

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11

M., Hasmadi, Nor Qhairul Izzreen M.N., A. H. Mansoor, M. H. A. Jahurul, and M. K. Zainol. "Chemical compositions and volatile compounds of Sabah indigenous durian (Durio dulcis Becc.)." Food Research 5, no. 2 (2021): 379–85. http://dx.doi.org/10.26656/fr.2017.5(2).545.

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The objective of this present work is to determine the chemical compositions and volatile compounds of Sabah indigenous durian (Durio dulcis Becc.). The results obtained showed that durian had 56.1% moisture, 3.5% protein, 2.8% fat, 1.4% ash, 36.26% carbohydrate, 6.6% dietary fiber and 7.0 µg of vitamin A. The mineral analysis results indicated that Durio dulcis is a good source of potassium, magnesium and phosphorus. Protein analysis found a total of sixteen major amino acids present in durian namely aspartame, serine, glutamin acid, glycine, histidine, arginine, threonine, alanine, proline,

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12

Stegantseva, M. V., V. A. Shinkevich, K. P. Vashkevich, T. M. Mikhaleuskaya, and A. N. Meleshko. "POLYETHYLENIMINE INCREASES THE IMMUNOGENICITY OF DNA-VACCINE BASED ON THE THYROSINE HYDROXYLASE GENE IN THE MOUSE MODEL OF NEUROBLASTOMA." Proceedings of the National Academy of Sciences of Belarus, Medical series 15, no. 3 (2018): 323–30. http://dx.doi.org/10.29235/1814-6023-2018-15-3-323-330.

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13

Lehtosalo, J., L. Eränkö, A. Palkama, and H. Uusitalo. "Nerve fibers showing immunoreactivities for thyrosine hydroxylase and dopamine-beta-hydroxylase re-appear in the guinea pig uvea after sympathectomy." Acta Ophthalmologica 66, no. 4 (2009): 419–26. http://dx.doi.org/10.1111/j.1755-3768.1988.tb04034.x.

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14

Chami, L., N. Lassau Mrs, S. Koscielny, B. Benatsou, A. Roche, and A. Le Cesne. "Quantitative functional imaging by dynamic contrast enhanced ultrasonography (DCE-US) in patients with GIST treated by thyrosine kinase inhibitor (TKI)." Journal of Clinical Oncology 26, no. 15_suppl (2008): 10552. http://dx.doi.org/10.1200/jco.2008.26.15_suppl.10552.

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15

Wang, Min, Chun Ling Jiang, Man Li Xia, Chun Yan Wang, and Qi YingYao. "Role of brain angiotensin AT1 receptor in carbachol-induced natriuresis and expression of thyrosine hydroxylase in the rostral ventrolateral medulla." Cell Biology International 32, no. 3 (2008): S64. http://dx.doi.org/10.1016/j.cellbi.2008.01.272.

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16

Rauschenbach, I. Y., L. V. Shumnaya, T. M. Khlebodarova, N. A. Chentsova, and L. G. Grenback. "Role of phenol oxidases and thyrosine hydroxylase in control of dopamine content in Drosophila virilis under normal conditions and heat stress." Journal of Insect Physiology 41, no. 3 (1995): 279–86. http://dx.doi.org/10.1016/0022-1910(94)00089-y.

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17

Ulisse, S., E. A. Jannini, E. Carosa, D. Piersanti, F. M. Graziano, and M. D'Armiento. "Inhibition of aromatase activity in rat Sertoli cells by thyroid hormone." Journal of Endocrinology 140, no. 3 (1994): 431–36. http://dx.doi.org/10.1677/joe.0.1400431.

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Abstract Basal and FSH-induced aromatase activity in prepubertal rat Sertoli cells was inhibited by l-tri-iodothyronine (T3) in a time- and dose-dependent manner. The effect was evident only after 6 h of preincubation with T3 (10−7 m) and the half-maximal dose was 0·5 ±0·2 nm, which correlated with the Kd of the nuclear T3 receptor of rat Sertoli cells (Kd=1–2 nm). The effect was specific as judged by the lack of effect of the T3 analogue 3-iodo-l-thyrosine. The inhibitory effect of T3 was present over the entire range of FSH concentrations used (0·001–100 ng/ml). In T3-treated Sertoli cells,

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18

Buchmann, Niels, Benjamin Kläsner, Jens Gempt, et al. "18F-Fluoroethyl-l-Thyrosine Positron Emission Tomography to Delineate Tumor Residuals After Glioblastoma Resection: A Comparison with Standard Postoperative Magnetic Resonance Imaging." World Neurosurgery 89 (May 2016): 420–26. http://dx.doi.org/10.1016/j.wneu.2016.02.032.

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19

Ben Fredj, W., Y. Ben Youssef, K. Zahra, et al. "Évaluation des résultats thérapeutiques de la thérapie ciblée par les inhibiteurs de la thyrosine kinase dans la leucémie myéloïde chronique du sujet âgé." La Revue de Médecine Interne 33 (December 2012): A154. http://dx.doi.org/10.1016/j.revmed.2012.10.264.

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20

Eghtedar, Alireza, Hagop Kantarjian, Elias Jabbour, et al. "Outcome After Failure to Second Generation Thyrosine Kinase Inhibitors(TKI) Treatment as Frontline Therapy for Patients with Chronic Myeloid Leukemia (CML) In Chronic Phase(CP)." Blood 116, no. 21 (2010): 3442. http://dx.doi.org/10.1182/blood.v116.21.3442.3442.

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Abstract Abstract 3442 Background: Imatinib has been the standard frontline therapy for patients with CML in early CP. 2nd generation TKIs (nilotinib, dasatinib) have been reported to be more effective than imatinib as frontline therapy in rates of response and transformation. Nilotinib has received regulatory approval for this indication and others (dasatinib, bosutinib) may come soon. Although fewer patients are expected to experience failure to therapy with the use of these agents, these patients will represent a management challenge. The characteristics, management and outcome of patients

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21

Ribera, Josep-María, Olga García, Pascual Fernández-Abellán, et al. "Lack of negative impact of Philadelphia chromosome in older patients with acute lymphoblastic leukaemia in the thyrosine kinase inhibitor era: comparison of two prospective parallel protocols." British Journal of Haematology 159, no. 4 (2012): 485–88. http://dx.doi.org/10.1111/bjh.12043.

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22

Molica, Stefano, Diana Giannarelli, and Emili Montserrat. "Comparison between Time-Limited,Venetoclax-Based and Continuous Bruton Thyrosine Kinase Inhibitors-Based Therapy in the Upfront Treatment of Chronic Lymphocytic Leukemia (CLL):a Systematic Review and Network Meta-Analysis." Blood 136, Supplement 1 (2020): 5–6. http://dx.doi.org/10.1182/blood-2020-137405.

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Background: Targeted agents (TAs) have shown impressive activity in the upfront treatment of chronic lymphocytic leukemia (CLL). However, TAs have rarely been compared in head-to-head clinical trials. With this background, a systematic literature review and network meta-analysis (NMA) was performed to estimate the relative efficacy of TAs approved by the FDA and/or EMA for upfront therapy of CLL (i.e., ibrutinib, acalabrutinib, and venetoclax). Methods: A systematic search of MEDLINE, EMBASE, BioSciences Information Service, and the Cochrane Library databases was conducted. Eligible studies co

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23

Lassau, N., S. Koscielny, M. Chebil, et al. "Functional imaging using DCE-US: Which parameter for the early evaluation of antiangiogenetic therapies?" Journal of Clinical Oncology 27, no. 15_suppl (2009): 3524. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.3524.

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3524 Background: The early evaluation of anti-angiogenic treatments is a challenge in oncology. Functional imaging methods based on the measure of tumoral vascularization have been developed using different modalities (CT, MRI, US). We analyzed the response in four studies using different targeted treatments with dynamic contrast enhanced-ultrasonography (DCE-US). Seven parameters characterizing tumoral perfusion were estimated. The objective of the study was to determine which parameter is the most appropriate to confirm earlier the efficacy of treatments. Methods: A total of 823 DCE-US were

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24

Dresemann, Antje, and Gregor Paul Dresemann. "Everolimus (E) and octreotid (O) in metastatic high-risk MEN IIb disease: A case report." Journal of Clinical Oncology 31, no. 15_suppl (2013): e13565-e13565. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e13565.

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e13565 Background: Multiple endocrine neoplasia (MEN) type IIB is characterized by missense mutation in exon 16 of the RET-proto-onkogen. Malignant c-cell-(medullar)-carcinoma of the thyroid gland (MTC) is part of the disease. Prognostic factors for metastatic MTC (m-MTC) are tumor grading, vessel- and peri-neural infiltration, age and performance status (PS). Irradiation and chemotherapy have limited activity in m-MTC. Thyrosine-kinase inhibitors like vandetanib, sorafenib or sunitinib were not admitted in Germany in 2011, August. As mTor-pathway seems to play a role in m-MTC E was suggested

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25

Skokowa, Julia, Dan Lan, Murat Uenalan, Kshama Gupta, and Karl Welte. "HS1 (HCLS1) Protein, a Binding Partner of HAX1, Induces G-CSF-Triggered Granulopoiesis Via LEF-1 Transcription Factor." Blood 114, no. 22 (2009): 548. http://dx.doi.org/10.1182/blood.v114.22.548.548.

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Abstract Abstract 548 Mutations in HS1 (HCLS1) associated protein × 1 (HAX1) have been described in patients with severe congenital neutropenia (CN). HAX1 is a ubiquitously expressed and until now it was unclear how HAX1 mutations cause isolated neutropenia in CN patients. So we were interested in investigating G-CSF-dependent HS1 (HCLS1) protein expression and phosphorylation in CN patients compared to healthy individuals, since HS1 (HCLS1) is a hematopoietic-specific protein and may link HAX1 to the G-CSFR signaling via the tyrosine kinases lyn and syk. Indeed, we found that treatment of CD3

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Henriksen, O. M., V. A. Larsen, A. Muhic, et al. "O7.08 * ONE-STOP SHOPPING IN BRAIN TUMOR IMAGING: INITIAL EXPERIENCE WITH PET/MR FOR SIMULTANEOUS EVALUATION OF TUMOR METABOLISM, STRUCTURE AND BLOOD VOLUME USING [18F]-FLUOR-ETHYL-THYROSINE PET AND DSC-MRI." Neuro-Oncology 16, suppl 2 (2014): ii16—ii17. http://dx.doi.org/10.1093/neuonc/nou174.59.

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27

Dolata, MD, Wojciech K. "Megakariocytic Hypoplasia Due To TKIs In a CML Patient Can Be Overcome By TPO Receptor Agonist Eltrombopag." Blood 122, no. 21 (2013): 5178. http://dx.doi.org/10.1182/blood.v122.21.5178.5178.

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Background Patients who develop severe thrombocytopenia while treated with TK inhibitors may be forced to stop them, face a worse prognosis, and eventually require a treatment with a bone marrow transplant. Eltrombopag is a TPO receptor agonist that stimulates megakaryocytic proliferation. Case 62-year-old man presented in October 2008 with splenomegaly and leukocytosis. The bone marrow biopsy was diagnostic of CML. Imatinib was started at 400 mg daily resulting in hematological response and resolution of splenomegaly, but severe thrombocytopenia necessitated 50 % dose reduction. Thrombocytope

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28

Wang, Jishi, Chanjuan Wang, Dan Ma, Qin Fang, and Mei Ren. "Mir-217 Reverses the TKI Drug-Resistance of K562 Cells By the Downregulation of Heme Oxygenase-1." Blood 126, no. 23 (2015): 5138. http://dx.doi.org/10.1182/blood.v126.23.5138.5138.

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Abstract Upregulation of Heme oxygenase-1 (HO-1) strengthens drug-resistance to apoptotic death in the several kinds of cancer cells. Our recent study shows the higher levels of HO-1 expression in the thyrosine kinase inhibitors (TKI) resistance K562 cell line and cells from Imatinb-insensitive CML patients. The cause of HO-1 upregulating, though, is still unclear yet. MicroRNAs (miRNAs) play a significant role in the pathogenesis of cancer. They also are known as potential biomarkers and therapeutic targets. In the hematological neoplasm, miRNAs take part in not only cancer development, but a

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29

Toren, Amos, Bella Bielorai, Jasmine Jacob-Hirsch, et al. "Hematopoietic Stem Cells “Stemness” Genes Contain Many Genes Mutated or Abnormally Expressed in Hematopoietic Malignancies." Blood 104, no. 11 (2004): 4125. http://dx.doi.org/10.1182/blood.v104.11.4125.4125.

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Abstract Umbilical cord blood (CB) and mobilized peripheral blood (PB) are relatively new sources of hematopoietic stem cells (HSC) that have been increasingly used in clinical transplantations. The genetic basis of the underlying mechanism of HSC self- renewal and differentiation has not been elucidated yet. Several groups have recently used microarray technology to study the common characteristics of stem cells from different tissues (“stemness”) and the typical features of each source of stem cell (“specificity”). Most groups focused their study on mice, used relatively small cDNA microarra

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30

Hara, Koichi, Koichi Uchida, Atsushi Fukunaga, Shigeo Toya, and Takeshi Kawase. "Implantation of Xenogeneic Transgenic Neural Plate Tissues into Parkinsonian Rat Brain." Cell Transplantation 6, no. 5 (1997): 515–19. http://dx.doi.org/10.1177/096368979700600513.

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Xenografting must be considered as a means of establishing neural transplantation therapy and of securing fetal neural tissues as donor material. The early stage (embryonic day 8.5, E8.5) embryonic mesencephalic neural plate (NP) from transgenic mice was examined for possible application in effective xenografting therapy. As recipients, Parkinsonian rats treated with 6-hydroxydopamine were used, and as donors, GT4-2 mice into which a β-galactosidase gene was introduced to allow brain tissue differentiation from the recipients by X-gal staining. Three microscopic pieces of E8.5 GT4-2 mice NP we

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Suknuntha, Kran, Yuki Ishii, Kejin Hu, et al. "Induced Pluripotent Stem Cell Model of Chronic Myeloid Leukemia Revealed Olfactomedin 4 As a Novel Survival Factor for Primitive Leukemia Cells." Blood 124, no. 21 (2014): 397. http://dx.doi.org/10.1182/blood.v124.21.397.397.

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Abstract CML is a myeloproliferative disorder characterized by unregulated growth of predominantly myeloid cells, and their subsequent accumulation in the bone marrow and peripheral blood. CML originates in hematopoietic stem cells (HSCs) with t(9;22)(q34;q11.2) translocation, which causes the constitutively expression of the BCR-ABL kinase driving the expansion of leukemic progeny. Ex vivo cultures of CML-derived cell lines and primary CML cells, ectopic expression of BCR-ABL in CD34+ cells and mouse models have provided important insights into CML pathogenesis and led to the development of t

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32

Tam, Teresa W., Humayoun Akhtar, John Thor Arnason, et al. "Inhibition of Human Cytochrome P450 Metabolism by Blended Herbal Products and Vitamins." Journal of Pharmacy & Pharmaceutical Sciences 14, no. 1 (2011): 1. http://dx.doi.org/10.18433/j3n30w.

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Purpose. The use of supplements as herbal and micronutrient natural health products with conventional health products has become increasingly popular. It has been reported that some herbal products can inhibit the activity of cytochrome P450-mediated metabolism and drug disposition. This study was designed to investigate a case report of a severe adverse event to determine the potential interactions of femMED, Thyrosense and vitamins on cytochrome P450-mediated drug metabolism. Methods. The effect of extracts from these commercially available herbal formulations, trans-ß-carotene, multiv

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Hershman, Jerome M. "THYROSIM Is an Online Tool for Estimating Serum TSH, T4, and T3." Clinical Thyroidology 28, no. 4 (2016): 100–102. http://dx.doi.org/10.1089/ct.2016;28.100-102.

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Ribera, Josep-Maria. "Acute lymphoblastic leukemia in adults." Pediatric Reports 3, no. 2s (2011): 1. http://dx.doi.org/10.4081/pr.2011.s2.e1.

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Acute lymphoblastic leukemia (ALL) is the most frequent neoplastic disease in children, being a rare disease in adults. Many of the advances in pediatric ALL have been through modifications in the doses and schedules of available agents as opposed to the introduction of new compounds. In recent years some improvements in the outcome of ALL in adults have occurred. Application of pediatric regimens to young and middle-aged adults shows promise to improve outcome. Advances in the supportive care of patients undergoing allogeneic stem cell transplantation (SCT), the use of alternative sources of

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Han, Simon X., Marisa Eisenberg, P. Reed Larsen, and Joseph DiStefano. "THYROSIM App for Education and Research Predicts Potential Health Risks of Over-the-Counter Thyroid Supplements." Thyroid 26, no. 4 (2016): 489–98. http://dx.doi.org/10.1089/thy.2015.0373.

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36

Gruza, Henryk, Dorota Gryko, and Janusz Jurczak. "The highly diastereoselective addition of lithium trimethylacetylene to N-Boc-O-Me-L-thyrosinal - synthesis directed towards anisomycin." Arkivoc 2004, no. 3 (2004): 112–19. http://dx.doi.org/10.3998/ark.5550190.0005.311.

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Sviridenko, N. Y., E. F. Tugeeva, M. A. Aripov, and Yu I. Buziashvili. "Cardiac functional reserve and left ventricular parameters in patients with diffuse toxic goiter after drug correction of euthyroidism with thiamazol." Problems of Endocrinology 55, no. 3 (2009): 21–24. http://dx.doi.org/10.14341/probl200955321-24.

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The aim of the investigation was to assess the time course of structural-and-functional and spatiogeometric changes following drug correction of euthyroidism in patients with diffuse toxic goiter and to determine prospects for restoring the cardiac functional reserve after elimination of thyrotoxicosis. The geometric parameters of the left ventricle (LV) and the readings of tissue Doppler echocardiography and exercise tests were compared in 27 female patients (mean age 53.3±9.2 years) who had thyrotoxicosis and 6 months after thyrosole-induced normalization of thyroid-stimulating and thyroid h

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Le Bricon, Thierry, Konstantin Stoitchkov, Sabine Letellier, et al. "Simultaneous analysis of thyrosinase mRNA, L/DOPA and L/Tyrosine in the blood of patients with metastatic malignant melanoma." European Journal of Cancer 35 (September 1999): S372. http://dx.doi.org/10.1016/s0959-8049(99)81929-7.

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39

Jafarian, Amir Hossein, Melika Kooshki forooshani, Farzane Farzad, and Nema Mohamadian Roshan. "The Relationship Between Fibroblastic Growth Factor Receptor-1 (FGFR1) Gene Amplification in Triple Negative Breast Carcinomas and Clinicopathological Prognostic Factors." Iranian Journal of Pathology 14, no. 4 (2019): 299–304. http://dx.doi.org/10.30699/ijp.2019.96713.1952.

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Background & Objective: In Triple-Negative Breast Cancers (TNBCs), estrogen receptor (ER), progesterone receptor (PR) and HER2/neu genes are not expressed. Fibroblastic Growth Factor Receptor-1 (FGFR1) gene product is a protein that acts as a receptor of thyrosin kinase. It plays a role in the proliferation, differentiation, and migration of malignant cells. The objective was to evaluate the possible relation between FGFR1 over-expression and amplification in TNBCs and other clinicopathological variables. Methods: In this cross sectional study, purposive sampling was used to collect eighty

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Procopio, Giuseppe, Alessia Mennitto, Massimo Di Maio, et al. "Cabozantinib (Cabo) beyond progression improves survival in advanced renal cell carcinoma patients: The CABEYOND study (Meet-Uro 21)." Journal of Clinical Oncology 39, no. 6_suppl (2021): 320. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.320.

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320 Background: The multikinase inhibitor cabozantinib (Cabo) is an effective treatment option for metastatic renal cell carcinoma (mRCC). However, data on the optimal sequencing of Cabo and other available therapies are lacking. In particular, the strategy of continuing Cabo administration after disease progression (PD) has never been investigated yet. In light of its ability of inhibiting MET and AXL, which are implied in VEGFR acquired resistance, the hypothesis of a prolonged efficacy in slowing tumor growth, despite first radiological PD, is worth to be investigated. Methods: We conducted

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Olivieri, Attilio, Michele Cimminiello, Paolo Corradini, et al. "Imatinib as Salvage Therapy for Patients with Refractory cGVHD: the Interim Analysis of the Prospective GITMO* Multicenter Study*Gruppo Italiano Trapianto Di Midollo Osseo." Blood 114, no. 22 (2009): 3558. http://dx.doi.org/10.1182/blood.v114.22.3558.3558.

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Abstract Abstract 3558 Poster Board III-495 We recently reported in a pilot study, including 19 adult and pediatric patients affected by refractory cGvHD with fibrotic features, that the administration of Imatinib at low dose was well tolerated and effective, achieving an overall response rate (ORR) of 79% at 6 months; the response has been evaluated according to the modified Curiel Criteria. We report here the preliminary results of an Italian GITMO Multicenter study, aimed to confirm these promising data. Main objective of this study was to assess the response rate, evaluated according to th

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Benjamini, Ohad, Hagop M. Kantarjian, Mary Beth Rios, et al. "Patient (Pt)-Driven Discontinuation of Tyrosine Kinase Inhibitor Theray in Chronic Phase Chronic Myeloid Leukemia (CML) - Single Institution Experience." Blood 120, no. 21 (2012): 3783. http://dx.doi.org/10.1182/blood.v120.21.3783.3783.

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Abstract Abstract 3783 Introduction: Some recent studies have reported on the outcome of CML pts who discontinued thyrosin kinase inhibitors (TKI) after achieving sustained undetectable bcr-abl transcript level. Most patients who stop TKI have experienced molecular relapse. Most patients respond after resuming TKIs regaining undetectable bcr-abl transcript levels. These series have prospectively planned treatment discontinuation and included only pts that have sustained complete molecular response (CMR) for at least 2 yrs. However, in many instances pts may want to discontinue TKIs not in CMR.

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Ditting, Tilmann, Christian Fiedler, Wolfgang Freisinger, et al. "Abstract 473: Evidence for Afferent Re-innervation After Renal Denervation in Rats." Hypertension 60, suppl_1 (2012). http://dx.doi.org/10.1161/hyp.60.suppl_1.a473.

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Interventional renal ablation is a promising treatment procedure for therapy-resistant arterial hypertension. However, the underlying mechanisms are not completely understood: The efferent sympathetic renal nerves are known to play a key role in salt retention and renin release, but the role of the afferent nerves is not yet clearly defined, although strong evidence exists for a sympathoinhibitory function. It is widely accepted that there is some re-innervation of efferent sympathetic nerves after the denervation procedure, but re-innervation of afferent nerves is still doubted. Hence, we wan

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