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Journal articles on the topic 'Thyroxine Sodium'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

&NA;. "Reduced thyroxine absorption with sodium polystyrene sulfonae." Inpharma Weekly &NA;, no. 889 (1993): 25. http://dx.doi.org/10.2165/00128413-199308890-00063.

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2

Renuka, Keshri, Praveen Arshi, Kaushav Rajni, and Jha Abhilasha. "Outcome of Treating Primary Hypothyroidism in Correction of Mildly Elevated Serum Prolactin Level in Menstrual Disorders." International Journal of Pharmaceutical and Clinical Research 15, no. 5 (2023): 1397–99. https://doi.org/10.5281/zenodo.12599057.

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<strong>Introduction: </strong>Association of hyperprolactinemia with primary hypothyroidism is well known in the literature however, marked elevation of serum prolactin in subclinical hypothyroidism (SCH) has not been commonly reported. Elevated levels of serum thyroid stimulating hormone (TSH) and serum prolactin are seen in different menstrual irregularities. <strong>Method: </strong>In our study, we have assessed serum prolactin and serum TSH levels in females suffering from menstrual disorders and implication of treatment of primary hypothyroidism on serum prolactin level.&

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3

Shakir, K. M. Mohamed, David Turton, Brian S. Aprill, Almond J. Drake, and Radm John F. Eisold. "Anemia: A Cause of Intolerance to Thyroxine Sodium." Mayo Clinic Proceedings 75, no. 2 (2000): 189–92. http://dx.doi.org/10.4065/75.2.189.

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4

El-khateeb, S. Z. "Spectrophotometric Determination of Thyroxine Sodium with p-Benzoquinone." Analytical Letters 22, no. 10 (1989): 2223–32. http://dx.doi.org/10.1080/00032718908051251.

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5

Shakir, K. M. Mohamed, David Turton, Brian S. Aprill, Almond J. Drake, and Radm John F. Eisold. "Anemia: A Cause of Intolerance to Thyroxine Sodium." Mayo Clinic Proceedings 75, no. 2 (2000): 189–92. http://dx.doi.org/10.1016/s0025-6196(11)64193-1.

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6

Clauss, W., B. Hoffmann, R. Krattenmacher, and W. Van Driessche. "Current-noise analysis of Na absorption in the embryonic coprodeum: stimulation by aldosterone and thyroxine." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 265, no. 5 (1993): R1100—R1108. http://dx.doi.org/10.1152/ajpregu.1993.265.5.r1100.

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The mechanism and regulation of sodium transport in the embryonic coprodeum of chicken were investigated with isolated epithelia in vitro by electrophysiological techniques. Electrogenic sodium transport (INa) was measured in Ussing chambers by the short-circuit current (Isc) technique and identified by the diuretic amiloride or by removal of sodium from the apical medium. Apical sodium channels and the kinetics of amiloride binding were investigated by current-noise analysis. Isc and INa were measured under control conditions and under the influence of in vitro incubation with aldosterone and

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7

Munera, Y., F. C. Hugues, C. Le Jeunne, and J. F. Pays. "Drug points: Interaction of thyroxine sodium with antimalarial drugs." BMJ 314, no. 7094 (1997): 1593. http://dx.doi.org/10.1136/bmj.314.7094.1593.

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8

Sergalieva, Mariyam U., Alexandra A. Tsybizova, Lyudmila A. Andreeva, Nikolay F. Myasoedov, Olga A. Bashkina, and Marina A. Samotrueva. "Effect of glyprolins on white blood cell parameters and phagocytic activity of neutrophils in conditions of experimental hyperthyroidism." Bulletin of the Russian Military Medical Academy 24, no. 1 (2022): 55–60. http://dx.doi.org/10.17816/brmma88670.

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This study investigated the effects of glyproline neuropeptide compounds (selank and Pro-Gly-Pro) on the white blood cell count and phagocytic activity of neutrophils in 40 nonlinear white male rats aged 68 months with experimental hyperthyroidism. Experimental hyperthyroidism was simulated by intragastric administration of L-thyroxine sodium salt pentahydrate at a dose of 150 g/kg/day for 21 days. All animals were equally divided into four groups: healthy rats (control), rats treated with L-thyroxine sodium pentahydrate (hyperthyroidism), rats treated with selank, and rats treated with Pro-Gl

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9

Michael, U. F., J. L. Logan, and L. A. Meeks. "The beneficial effects of thyroxine on nephrotoxic acute renal failure in the rat." Journal of the American Society of Nephrology 1, no. 11 (1991): 1236–40. http://dx.doi.org/10.1681/asn.v1111236.

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We were able to confirm previous studies demonstrating that administration of thyroxine is capable of ameliorating the severity of acute nephrotoxic renal failure in the rat. Nephrotoxic acute renal failure was induced by the subcutaneous injection of potassium dichromate (6.25 mg/kg) into Sprague-Dawley rats. Twenty-four hours after this injection, rats received an intraperitoneal injection of either thyroxine (80 micrograms/kg body wt) or normal saline. Forty-eight hours after the potassium dichromate injection, renal clearance studies were performed. Inulin clearance was significantly highe

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10

Ljunggren, J. G., and B. Persson. "SUBCUTANEOUS ADMINISTRATION OF SODIUM L-THYROXINE TO PATIENTS WITH HYPOTHYROIDISM." Acta Medica Scandinavica 197, no. 1-6 (2009): 471–72. http://dx.doi.org/10.1111/j.0954-6820.1975.tb04954.x.

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11

Kaveri, Jagtap* Rahul Jagtap. "A Review on Thyroxine Sodium: Pharmacovigilance, Potential Indications, Interactions, Precautions." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1020–25. https://doi.org/10.5281/zenodo.12739585.

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ADRs. A growing trend in pharmacovigilance is to connect premarketing data with human safety information observed during the post-marketing phase. Pharmacovigilance is crucial in healthcare, focusing on assessing, monitoring, and identifying interactions between drugs and their effects on humans. While pharmaceutical and biotechnological medications aim to cure, prevent, or treat diseases, they also carry risks, such as adverse drug reactions (ADRs), which can harm patients. Therefore, monitoring ADRs is essential for medication safety throughout its lifecycle, including during drug developmen

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12

Sherwani, F. A. "Effect of thyroxine on Na+/K+-ATPase and SDH activities in gills and kidney during osmotic adjustments of Heteropneustes fossilis at higher salinity." Journal of Environmental Biology 44, no. 1 (2023): 73–82. http://dx.doi.org/10.22438/jeb/44/1/mrn-4059.

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Aim: The aim of the present study was to investigate the facilitatory role of thyroxine during adaptation process of catfish, Heteropneustes fossilis in higher salinity following its exogenous administration by monitoring changes in plasma osmolality, branchial and renal sodium-potassium dependent adenosine triphosphatase and succinic dehydrogenase enzyme activity profiles and study the effect of direct transfer of fish to higher salinities on plasma thyroxine levels. Methodology: Catfish were directly transferred from tap water to 30 and 35% sea water and plasma thyroxine profiles were analys

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13

Nagaraju, Mareedu, and Devi Sunitha. "Response of Skeletal Muscle Protein and Nucleic Acid Levels to Thyroxine Injection in Fish." Biolife 1, no. 1 (2022): 1–4. https://doi.org/10.5281/zenodo.7180793.

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<strong>ABSTRACT</strong> The action of thyroxine (T4) at the peripheral cellular level in fish largely remains unknown. The effect of Thyroxine (T4) injection on certain aspects of protein metabolism was studied under constant temperature (26±1°C.), nutritional status and same age group of fish, Anabas testudineus. Commercially available Thyroxine-L-sodium, T4 was given in the form of injection. Two dosages of hormone were selected (4µg/10g and 8µg/10g body weight). For cumulative study, the fish received daily intraperitoneal injections of T4 for one and two weeks. Sin

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14

Sergalieva, M. U., A. A. Tsibizova, and M. A. Samotrueva. "Effects of Glyprolins on Lipid and Protein Peroxidation in the Hypothalamic Region in Experimental Hyperthyroidism." Journal Biomed 20, no. 1 (2024): 62–72. http://dx.doi.org/10.33647/2074-5982-20-1-62-72.

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We investigate effects of glyproline-type neuropeptides on lipid and protein peroxidation in the hypothalamic brain region of rats under the conditions of experimental hyperthyroidism. The state of hyperthyroidism in animals was simulated by intragastric administration of sodium pentahydrate of L-thyroxine at a dose of 150 µg/kg for 21 days. The following experimental groups (n=10) were formed: 1) control group — intact animals (control); 2) animals treated with L-thyroxine sodium salt pentahydrate (hyperthyroidism); 3) animals treated with Thr-Lys-Pro-Arg-Pro-Gly-Pro (celank); 4) animals trea

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15

A. Yonkers, Marc, and Angeles B. Ribera. "Nongenomic Thyroxine Regulation of Voltage-gated Sodium Current During Embryonic Development." Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry 11, no. 3 (2011): 157–64. http://dx.doi.org/10.2174/187152211796642800.

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16

Ma, Yu-Ping, Hui-Juan Hu, Xue-Mei Hao, Pei-Ai Zhou, Cai-Hong Wu, and De-Zai Dai. "Reduced sodium currents in isolated mammalian myocytes treated with chronicL-thyroxine." Drug Development Research 58, no. 1 (2003): 111–15. http://dx.doi.org/10.1002/ddr.10138.

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17

Curry, Stephen H., John G. Gums, Lisa L. Williams, R. Whitney Curry, and Bernard B. Wolfson. "Levothyroxine Sodium Tablets: Chemical Equivalence and Bioequivalence." Drug Intelligence & Clinical Pharmacy 22, no. 7-8 (1988): 589–91. http://dx.doi.org/10.1177/106002808802200715.

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Two brands of levothyroxine sodium tablets were compared in vivo for bioequivalence in a double-blind, randomized study. The tablets were identical in levothyroxine content. Evaluation was by means of triiodothyronine (uptake), tetraiodothyronine, free thyroxine index, total triiodothyronine by radioimmunoassay, and thyroid-stimulating hormone measurements. No differences in clinical response were found in a study with a high statistical power. It was concluded that the two brands were bioequivalent because of chemical equivalence, use of micronized levothyroxine powder in tablet production wi

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18

Ledeţi, Ionuţ, Adriana Ledeţi, Gabriela Vlase, et al. "Thermal stability of synthetic thyroid hormone l-thyroxine and l-thyroxine sodium salt hydrate both pure and in pharmaceutical formulations." Journal of Pharmaceutical and Biomedical Analysis 125 (June 2016): 33–40. http://dx.doi.org/10.1016/j.jpba.2016.03.026.

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19

Nosivets, D. S. "POSSIBILITY OF SHARING L-THYROXINE, DICLOFENAC SODIUM AND CHONDROITIN SULPHATE IN HYPOTHYROIDISM." Bulletin of Problems Biology and Medicine 2.1, no. 150 (2019): 172. http://dx.doi.org/10.29254/2077-4214-2019-2-1-150-172-176.

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20

Skinner, G. R. B., D. Holmes, A. Ahmad, J. A. Davies, and J. Benitez. "Clinical Response to Thyroxine Sodium in Clinically Hypothyroid but Biochemically Euthyroid Patients." Journal of Nutritional & Environmental Medicine 10, no. 2 (2000): 115–24. http://dx.doi.org/10.1080/13590840050043530.

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21

Michalkiewicz, M., L. J. Huffman, M. Dey, and G. A. Hedge. "Endogenous neuropeptide Y regulates thyroid blood flow." American Journal of Physiology-Endocrinology and Metabolism 264, no. 5 (1993): E699—E705. http://dx.doi.org/10.1152/ajpendo.1993.264.5.e699.

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Neuropeptide Y (NPY) is present in thyroid sympathetic nerve fibers. To assess the involvement of endogenous NPY in the regulation of thyroid function, a NPY antiserum was produced in a rabbit, characterized, and used for immunization of normal and hyperthyroid rats. Plasma thyroxine, thyroid-stimulating hormone (TSH), thyroidal, and other organ blood flows (BF) were measured in anesthetized (ketamine and pentobarbital sodium) male Sprague-Dawley rats at 1 h after intravenous administration of 1 ml of the antiserum, normal rabbit serum, or saline. Immunization against NPY had no effect on the

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22

Nagasawa, T., K. Ichikawa, K. Minemura, et al. "Differences in cellular transport of tri-iodothyronine and thyroxine: cell cycle-dependent alteration of tri-iodothyronine uptake." Journal of Endocrinology 147, no. 3 (1995): 479–85. http://dx.doi.org/10.1677/joe.0.1470479.

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Abstract Cellular and nuclear uptake of tri-iodothyronine (T3) and thyroxine (T4) was examined using the cultured cell line derived from rat liver, clone 9, and rat hepatoma, dRLH-84. The saturable cellular uptake of T3 and T4 was demonstrated in these cells. First we examined the cell cycle-dependent alteration of thyroid hormone uptake. Cellular T3 uptake was minimal in the early G1 phase and increased in the late G1 phase, reaching a maximal level in the S phase. Alterations in nuclear T3 uptake were in accordance with the changes in cellular T3 uptake. On the other hand, cellular and nucle

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23

Mohammed, Dr Taghreed Uloom, Bushra H.Ali, Rajaa K.Baker, and Dheefaf F. Hassan. "Effect of Aqueous Extract of Vitis Vinifera l. Leaf on the Rabbit Females Have Highly Thyroxine Induced by Levothyroxine Sodium." JOURNAL OF ADVANCES IN CHEMISTRY 4, no. 3 (2008): 482–87. http://dx.doi.org/10.24297/jac.v4i3.944.

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L-Thyroxine(T4) and triiodothyronine(T3)are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis. The aqueous extract of vitis vinifera L. was investigated for its effect on hormones in rabbits. The aqueous extract of plant at a dose level of 50µg/rabbit showed highly significant (p<0.05)on levels of hormones T4, TSH but TSH no significant. L-thyroxine sodium treated group showed a

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24

Sergalieva, M. U., A. A. Tsibizova, V. Kh Murtalieva, L. A. Andreeva, N. F. Myasoedov, and M. A. Samotrueva. "EFFECT OF ACTG(4-7)-PRO-GLY-PRO AND ACTG(6-9)-PRO-GLY-PRO ON THE INTENSITY OF REDOX PROCESSES AND BEHAVIOURAL STATUS OF RATS UNDER THYROID HYPERFUNCTION CONDITIONS." PROBLEMS OF BIOLOGICAL, MEDICAL AND PHARMACEUTICAL CHEMISTRY 27, no. 3 (2024): 49–55. http://dx.doi.org/10.29296/25877313-2024-03-08.

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The aim of the work is to study the effect of melanocortins on the intensity of redox processes in the prefrontal region of the brain and the behavioral status of rats against the background of thyroid hyperfunction. Material and methods. In the experiment, the test animals were divided into the following groups (n = 10): intact rats (control); animals treated with sodium salt pentahydrate L-thyroxine (hyperthyroidism); rats receiving ACTH (4-7)-Pro-Gly-Pro and individuals receiving ACTH (6-9)-Pro-Gly-Pro, re-spectively, intraperitoneally daily for 21 days, starting from day 22 of administrati

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25

Khan, F. A., and D. N. Baron. "Ion flux and Na+,K+-ATPase activity of erythrocytes and leucocytes in thyroid disease." Clinical Science 72, no. 2 (1987): 171–79. http://dx.doi.org/10.1042/cs0720171.

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1. In hyperthyroidism, erythrocytes show decreased Na+,K+-ATPase activity, decreased [3H]ouabain binding capacity (an index of the number of sodium pumps) and decreased active sodium and potassium flux rates, with a high intracellular sodium concentration. 2. As erythrocytes are non-nucleated and atypical cells, we have studied electrolyte status in thyroid disease using mixed leucocytes as well; the results obtained differed from those in erythrocytes. 3. When compared with findings in healthy subjects, leucocyte Na+,K+-ATPase activity, [3H]-oubain binding capacity, total and active rubidium

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26

Salami, Adeola Temitope, Chidinma Chukwukaeme, Olawande Olagoke, and Samuel Babafemi Olaleye. "Low-dose Potassium bromate enhances ischemia-reperfusion-induced gastric ulcer healing in Thyroidectomised Rats." Nigerian Journal of Physiological Sciences 38, no. 2 (2023): 171–85. http://dx.doi.org/10.54548/njps.v38i2.6.

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Gastric ulcer healing is impaired in both hypothyroid and hyperthyroid conditions. Thyroid hormones regulate growth, energy metabolism and mitochondrial oxidative metabolism. Xenobiotics have been documented to negatively impact the thyroid gland at high doses but the redox and cellular interactions at low doses during wound healing process remains unclear. Potassium bromate has been documented to be toxic at high doses but there is dearth of information on its activities at a low dose in varied thyroid states which was evaluated in this study. 60 male Wistar rats (g, n=10) were randomised int

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27

Bhatt, Parloop, Dharmesh Makwana, Devdas Santani, and Ramesh Goyal. "Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with l-thyroxin-induced hyperthyroidism — an experimental study." Canadian Journal of Physiology and Pharmacology 85, no. 5 (2007): 514–20. http://dx.doi.org/10.1139/y07-031.

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The present study was undertaken to investigate the effectiveness of adrenergic antagonists carvedilol and propranolol on l-thyroxin-induced cardiovascular and metabolic disturbances in rats. Treatment with l-thyroxin sodium (75 mg/kg body mass, s.c., every alternate day for 3 weeks), produced a significant increase in food and water intake, body temperature, heart rate, systolic blood pressure, along with an increase in serum T3, T4, and triglyceride levels. Besides a significant reduction in body mass, serum levels of TSH and cholesterol were also reduced following l-thyroxin treatment. Carv

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28

Samira Safaraliyeva, Samira Safaraliyeva. "STUDY OF TOXICITY OF L-THYROXIN IMMOBILIZED CHITOSAN AND THE NATURE OF DRUG-POLYMER INTERACTION." PAHTEI-Procedings of Azerbaijan High Technical Educational Institutions 12, no. 01 (2022): 53–61. http://dx.doi.org/10.36962/pahtei2101202253.

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It is known that L-thyroxine is used as a hormone substitute after goiter surgery. L-thyroxine contains sodium salt of levothyroxine, a synthetic substitute for the hormone of thyroxine. Absorption of the drug from the gastrointestinal tract is 48-79%. Its maximum concentration in plasma is reached after about 6 hours after acceptance. Levothyroxine, which is delivered mainly in combination with plasma proteins, is used in the liver, brain and muscles. Monoiodination of approximately 80% of sodium levothyroxine in various tissues occurs with the formation of triiodothyronine and inactive produ

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29

Nachreiner, R. F., and K. R. Refsal. "Radioimmunoassay monitoring of thyroid hormone concentrations in dogs on thyroid replacement therapy: 2,674 cases (1985-1987)." Journal of the American Veterinary Medical Association 201, no. 4 (1992): 623–29. http://dx.doi.org/10.2460/javma.1992.201.04.623.

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Summary Serum iodothyronine concentrations from 4,064 samples submitted for monitoring of thyroid replacement therapy were evaluated in a retrospective study. After exclusion of samples because of the presence of 3,5,3’ triiodothyronine (T3) autoantibodies, insufficient numbers of dogs on some commercial preparations or medication with corticosteroids or synthetic T3 preparations, data from 2,674 dogs remained. Data were analyzed by using information on dose, time after dosing, commercial product, and once-a-day or twice-a-day dosing regimens. Serum total thyroxine (T4) and total T3 and estima

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30

Li, Wai Ip, Tak Kwong Chan, Koon Kiu Ng, and Boom Ting Kung. "Predictive value of technetium-99m sodium pertechnetate thyroid scintigraphy in determining the permanence of congenital hypothyroidism." Journal of Clinical Imaging Science 15 (January 15, 2025): 3. https://doi.org/10.25259/jcis_79_2024.

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Objectives: We aim to investigate the predictive value of [99mTc] pertechnetate thyroid scintigraphy in determining the permanence of congenital hypothyroidism (CH). Material and Methods: A retrospective analysis of [99mTc] pertechnetate thyroid scans performed for evaluation of CH at the Nuclear Medicine Unit of a hospital in Hong Kong between January 1, 2008, and December 31, 2018, was conducted. Scintigraphic findings and parameters at diagnosis, including thyroid stimulating hormone (TSH), free thyroxine (fT4), gender, and gestational age, were reviewed. The need for lifelong thyroxine rep

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31

Sonmez Ince, Melda, and Ajaz Banka. "Syndrome of inappropriate antidiuretic hormone secretion in a patient with pituitary apoplexy." BMJ Case Reports 14, no. 2 (2021): e236787. http://dx.doi.org/10.1136/bcr-2020-236787.

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Pituitary apoplexy (PA) is an endocrine emergency presenting with headache, visual and hormonal disturbances. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is rare after PA. A 64-year-old woman presented with acute frontal headache and nausea with normal neurological examination. Labs included normal sodium and creatinine. Echo showed new-onset congestive heart failure (CHF) and MRI of the brain revealed PA. She had normal cortisol levels and low thyroid stimulating hormone with normal thyroxine (T4) levels. During her hospitalisation, patient developed hyponatraemia. Initia

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32

Berkner, Paul D., Harold Starkman, and Nils Person. "Acute l-thyroxine overdose; therapy with sodium ipodate: Evaluation of clinical and physiologic parameters." Journal of Emergency Medicine 9, no. 3 (1991): 129–31. http://dx.doi.org/10.1016/0736-4679(91)90317-9.

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33

Djelailia, H., N. M’Hamdi, R. Bouraoui, and T. Najar. "Effects of thermal stress on physiological state and hormone concentrations in Holstein cows under arid climatic conditions." South African Journal of Animal Science 51, no. 4 (2021): 452–59. http://dx.doi.org/10.4314/sajas.v51i4.5.

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This study was conducted to investigate the effect of heat stress on the physiology of dairy cows and to detect the relationship between rectal temperature (RT) and respiration rate (RR), heart rate (HR), and plasma concentrations of cortisol, thyroxine, and prolactin. During the experiment, 44 Holstein cows were allocated to two groups for each season. The average temperature-humidity index (THI) values were 55 ± 2.31 in winter and 78 ± 1.9 in summer. As the THI values increased from 55 to 78, RR rose by 35 inspirations per minute, HR by 3 beats per minute, and RT by 1.2 °C. In addition, the

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Williams, David A., J. Catharine Scott-Moncrieff, Joseph Bruner, et al. "Validation of an immunoassay for canine thyroid-stimulating hormone and changes in serum concentration following induction of hypothyroidism in dogs." Journal of the American Veterinary Medical Association 209, no. 10 (1996): 1730–32. http://dx.doi.org/10.2460/javma.1996.209.10.1730.

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Objective— To validate a new immunoradiometric assay for canine thyroid-stimulating hormone (cTSH) and to document changes in serum cTSH concentration during induction of hypothyroidism in dogs. Animals— Six healthy adult male Beagles. Procedure— Sensitivity, specificity, precision, and accuracy of the cTSH assay were evaluated in vitro. Hypothyroidism was induced in dogs by IV administration of sodium iodide I 131 solution. Subsequently, l-thyroxine was administered orally to normalize serum thyroxine concentrations. Results— The cTSH assay appeared to be specific and was sufficiently sensiti

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35

Haselman, Jonathan T., Jennifer H. Olker, Patricia A. Kosian, et al. "Targeted Pathway-based In Vivo Testing Using Thyroperoxidase Inhibition to Evaluate Plasma Thyroxine as a Surrogate Metric of Metamorphic Success in Model Amphibian Xenopus laevis." Toxicological Sciences 175, no. 2 (2020): 236–50. http://dx.doi.org/10.1093/toxsci/kfaa036.

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Abstract Chemical safety evaluation is in the midst of a transition from traditional whole-animal toxicity testing to molecular pathway-based in vitro assays and in silico modeling. However, to facilitate the shift in reliance on apical effects for risk assessment to predictive surrogate metrics having characterized linkages to chemical mechanisms of action, targeted in vivo testing is necessary to establish these predictive relationships. In this study, we demonstrate a means to predict thyroid-related metamorphic success in the model amphibian Xenopus laevis using relevant biochemical measur

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Matveyeva, S. L., O. S. Shevchenko, and O. Tudor. "IMPACT OF SELENIUM IN RESTORATION OF THYROID FUNCTION AND OUTCOMES OF ANTI-TUBERCULOSIS CHEMOTHERAPY IN THYROIDAL DYSFUNCTION." Інфекційні хвороби, no. 4 (November 24, 2023): 34–37. http://dx.doi.org/10.11603/1681-2727.2023.4.14245.

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The effect of selenium on thyroid status and outcomes of chemotherapy was studied at examination of 180 tuberculosis patients with the pathological structural changes of thyroid. A subclinical hypothyroidism was diagnosed at this category of patients. Subclinical hypothyroidism progressed under antituberculosis chemotherapy. Prescribing of selenium nitric restored thyroid function with the increasing of blood level of free thyroxine and decreasing of thyroid stimulating hormone and also optimized the results of chemotherapy with increasing the percentage of tuberculosis patients stopped bacill

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37

Yakubova, E. G. "Features of achieving compensation of hypothyroisis in pregnant women." Clinical and experimental thyroidology 19, no. 1 (2023): 29–34. http://dx.doi.org/10.14341/ket12743.

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BACKGROUND: Hypofunction of the thyroid gland in women at the pre-pregnancy stage and during pregnancy is associated with a high risk of congenital hypothyroidism in children, as a result of which irreversible changes in the nervous system are formed. Despite the mandatory intake of potassium iodide preparations, pregnant women often develop gestational hypothyroidism, which requires the appointment of levothyroxine. Many women have episodic hypofunction of the thyroid gland before pregnancy, associated with various factors. Diagnosed hypothyroidism requires hormonal correction. The recommende

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38

Chu, Chun, Jian Yi Li, Ruben J. Boado, and William M. Pardridge. "Blood—Brain Barrier Genomics and Cloning of a Novel Organic Anion Transporter." Journal of Cerebral Blood Flow & Metabolism 28, no. 2 (2007): 291–301. http://dx.doi.org/10.1038/sj.jcbfm.9600538.

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A novel organic anion transporter selectively expressed at the blood—brain barrier (BBB), originally designated BBB-specific anion transporter type 1 (BSAT1), and now classified as Slco1c1, has been cloned from a BBB genomics program as a partial cDNA; this study describes the cloning and expression of the full-length cDNA from a rat brain capillary cDNA library. Northern analysis revealed the selective expression of the transporter at the BBB, and the transporter was expressed after permanent transfection of human 293 cells with cDNA encoding either the full length or open reading frame mRNA.

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Cronin, R. E., and J. A. Newman. "Protective effect of thyroxine but not parathyroidectomy on gentamicin nephrotoxicity." American Journal of Physiology-Renal Physiology 248, no. 3 (1985): F332—F339. http://dx.doi.org/10.1152/ajprenal.1985.248.3.f332.

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Gentamicin nephrotoxicity increases renal cortex calcium and sodium and decreases renal cortex Na-K-ATPase activity. Human acute renal failure is accompanied by an increase in parathyroid hormone (PTH), a hormone that stimulates calcium uptake by tissues, and by a decrease in thyroid hormone, a hormone that increases renal cortex Na-K-ATPase activity. This study evaluated the role of extracellular calcium, PTH, and thyroxine in the pathogenesis of gentamicin nephrotoxicity. Chronically parathyroidectomized hypocalcemic rats (PTXG) given gentamicin (30 mg/kg s.c. twice daily for 8 days) were no

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Herenda, Safija, Anera Kazlagić, Edhem Hasković, Jelena Šćepanović, and Jasmina Marušić. "Effects of 99mTc on the electrochemical properties of thiamazole in vitro." Macedonian Journal of Chemistry and Chemical Engineering 40, no. 1 (2021): 21. http://dx.doi.org/10.20450/mjcce.2021.2148.

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Thiamazole inhibits the thyroid hormone synthesis and does not inactivate the existing thyroxine and triiodothyronine that circulate in the blood. In this paper Thiamazole electrochemical behavior was monitored by cyclic voltammetry on glassy carbon (GC) electrode in the absence and presence of sodium pertechnetate (99mTc). The influence of different Thiamazole concentrations without and in the presence of radiopharmaceutical 99mTc, the effect of the number of scan cycles, and the effect of 99mTc activity on the appearance of cyclic voltammograms were examined. The results show that there is a

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Nada Syazana, Huzairi Sani, and Zahir Izuan Azhar. "Thyroid Function Test as First-line Investigation of Hypernatremia: Is It Necessary?" Asian Journal of Medicine and Biomedicine 4, no. 1 (2020): 12–18. http://dx.doi.org/10.37231/ajmb.2020.4.1.322.

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Non-severe hypothyroidism has no strong association with hyponatremia. However, thyroid function tests (TFT) continue to be ordered as a first-line investigation. The objective of this study was to establish the prevalence of inpatient hyponatremia and to reiterate the association between thyroid disorders and hyponatremia based on study findings and current literature. A cross-sectional study on 3,478 in-patients adults of both gender admitted to a Malaysian tertiary hospital was carried out. Age, gender, sodium levels, thyroid stimulating hormone (TSH), free thyroxine (fT4) and clinical note

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Eynan, Mirit, Tanya Knubuvetz, Uri Meiri, et al. "Heat acclimation-induced elevated glycogen, glycolysis, and low thyroxine improve heart ischemic tolerance." Journal of Applied Physiology 93, no. 6 (2002): 2095–104. http://dx.doi.org/10.1152/japplphysiol.00304.2002.

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Based on our observations of energy sparing in heat-acclimated (AC) rat hearts, we investigated whether changes in preischemic glycogen level, glycolytic rate, and plasma thyroxine level mediate cardioprotection induced in these hearts during ischemia-reperfusion insults. Control (C) (24°C), AC (34°C, 30 days), acclimated-euthyroid (34°C + 3 ng/ml l-thyroxine), and control hypothyroid (24°C + 0.02% 6- n-propyl-2-thiouracil) groups were studied. Preischemic glycogen was higher in AC than in C hearts [39.0 ± 8.5 vs. 19.2 ± 4.2 (SE) μmol glucose/g wet wt; P < 0.0006], and the lactate produced

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Johnson, D. A., O. F. Alvares, K. R. Etzel, and D. N. Kalu. "Regulation of Salivary Proteins." Journal of Dental Research 66, no. 2 (1987): 576–82. http://dx.doi.org/10.1177/00220345870660023201.

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Previous studies have shown that several factors — such as alloxan-induced diabetes, adrenalectomy, or removal of the thyroid-parathyroid gland complex — can influence the flow rate, protein concentration, and protein composition of rat parotid saliva. The present study was undertaken to explore further the influence of glucocorticoids and thyroxine on rat parotid saliva in hormonally intact animals. As compared with untreated animals, adult male rats treated with 10 μg dexamethasone per 100 g body weight for eight days demonstrated a 75% reduction in volume of parotid saliva secreted in respo

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LE TRAON, G., S. BURGAUD, and L. J. I. HORSPOOL. "Pharmacokinetics of total thyroxine in dogs after administration of an oral solution of levothyroxine sodium." Journal of Veterinary Pharmacology and Therapeutics 31, no. 2 (2008): 95–101. http://dx.doi.org/10.1111/j.1365-2885.2007.00935.x.

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Yakymchuk, Оlexander М., Іvan М. Klishch, Alla V. Boychuk, and Yuliia В. Yakymchuk. "ACTIVATION OF ENDOGENOUS INTOXICATION UNDER THE INFLUENCE OF ANESTHETICS IN EXPERIMENTAL HYPERTHYROIDISM." Wiadomości Lekarskie 73, no. 10 (2020): 2224–26. http://dx.doi.org/10.36740/wlek202010122.

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The aim: To determine the features of endogenous intoxication in the blood of experimental animals in the setting of simulated hyperthyroidism under the influence of various anesthetics. Materials and methods: Rats were injected L-thyroxine to simulate hyperthyroidism, and sodium thiopental and dexmedetomidine in the setting of euthyroidism and hyperthyroidism. Results: An increase in the activity of endogenous intoxication, the content of medium-molecular peptides (MMW1, MMW2) and their coefficient (K = MSM2 / MSM1) were observed in the erythrocytes of experimental animals with hyperthyroidis

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Qureshi, Anum, and Ji Hyun Rhee. "Hyponatraemia due to hypothyroidism: a rare side effect from pomalidomide." BMJ Case Reports 14, no. 3 (2021): e240168. http://dx.doi.org/10.1136/bcr-2020-240168.

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Pomalidomide is an immunomodulatory drug used for relapsed and refractory multiple myeloma (RRMM). Hypothyroidism is an uncommon side effect of pomalidomide. We present a 70-year-old male patient with RRMM on daratumumab, pomalidomide and dexamethasone, who presented with 2 weeks of fatigue. Laboratory values showed sodium of 120 mEq/L, plasma osmolarity of 256 mOsm/kg, urine osmolarity of 648 mOsm/kg and urine sodium of 93 mEq/L. Adrenocorticotropic hormone (ACTH) stimulation test was within normal limits. Thyroid-stimulating hormone (TSH) was 88.6 IU/mL (0.380–4.700 IU/mL), total triiodothyr

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Brown, S. B., R. E. Evans, and Toshiaki J. Hara. "Interrenal, Thyroidal, Carbohydrate, and Electrolyte Responses in Rainbow Trout (Salmo gairdneri) during Recovery from the Effects of Acidification." Canadian Journal of Fisheries and Aquatic Sciences 43, no. 3 (1986): 714–18. http://dx.doi.org/10.1139/f86-087.

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Exposure to acid-treated water (H2SO4, pH 4.76) for 21 d increased plasma glucose, protein, and cortisol levels and interrenal nuclear diameter and decreased plasma electrolytes (Na+, Cl−) and osmolality in immature rainbow trout (Salmo gairdneri). Plasma L-thyroxine (T4), 3,5,3′-triiodo-L-thyronine (T3), or their ratio (T4:T3) were not altered by the acid treatment. Following termination of acid exposure, return to control levels was achieved within 1 d by plasma protein, 3 d by plasma cortisol, glucose, sodium, chloride, and osmolality, and 7 d by interrenal nuclear diameter. Thus, within 1

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Kates, Anna-Lisa, Ian R. A. Park, Jean Himms-Hagen, and Rudolf W. Mueller. "Thyroxine 5′-deiodinase in brown adipose tissue of the cynomolgus monkey Macaca fascicularis." Biochemistry and Cell Biology 68, no. 1 (1990): 231–37. http://dx.doi.org/10.1139/o90-031.

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Brown adipose tissue was identified in axillary, interscapular, subscapular, and cervical fat deposits of male and female cynomolgus monkeys (Macaca fascicularis) by histological and immunological techniques. Histology included staining of mitochondria with a Novelli stain and identification of mitochondria-rich multilocular cells. Immunological detection involved separation of homogenate proteins by sodium dodecyl sulphate – polyacrylamide gel chromatography, blotting on to nitrocellulose membranes, and identification of the specific uncoupling protein, unique to brown adipose tissue, with an

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Bertin, François R., Lauren Eichstadt Forsythe, and Janice E. Kritchevsky. "Effects of high doses of levothyroxine sodium on serum concentrations of triiodothyronine and thyroxine in horses." American Journal of Veterinary Research 80, no. 6 (2019): 565–71. http://dx.doi.org/10.2460/ajvr.80.6.565.

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Varnavsky, Vladimir S., Tatsuya Sakamoto, and Tetsuya Hirano. "Stunting of Wild Coho Salmon (Oncorhynchus kisutch) in Seawater: Patterns of Plasma Thyroid Hormones, Cortisol, and Growth Hormone." Canadian Journal of Fisheries and Aquatic Sciences 49, no. 3 (1992): 458–61. http://dx.doi.org/10.1139/f92-054.

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Under natural conditions, some coho salmon presmolts (Oncorhynchus kisutch) in Kamchatka have been observed to migrate prematurely to the sea and fail to grow in brackish water for prolonged periods (natural stunts). Plasma levels of growth hormone, cortisol, thyroxine, and triiodothyronine were measured in coho salmon parr captured in the river (freshwater), smolts migrating downstream captured at the river mouth (brackish water), smolts in the sea (seawater), and natural stunts in the inlet (brackish water). The physiological conditions of natural stunts seem analogous to those of hatchery-d

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