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1

GEYİKOĞLU, Miraç Dilruba, Hilal KOÇ, Bülent ÇAVUŞOĞLU, Mehmet ERTUGRUL, and Karim ABBASİAN. "Designing Graphene-Based Antenna for Terahertz Wave Ablation (TWA) System." Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi 15, no. 2 (2022): 507–14. http://dx.doi.org/10.18185/erzifbed.1014513.

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Cancer is one of the most feared health problems today. Studies on cancer diagnosis and treatment are carried out intensively. In this study, a graphene-based antenna is proposed for cancer diagnosis and treatment with THz radiation therapy, which is a relatively new radiation technique. A graphene-based two-layer monopole antenna is designed for 1.65THz operation frequency. To change the bandwidth and radiation pattern without changing the operating frequency, a graphene ring is placed on the SiO2 substrate (2nd layer).Antenna performance is analyzed for reflection coefficient, realized gain,
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Huang, Hsin-hui, Takeshi Nagashima, Tetsu Yonezawa, et al. "Giant Enhancement of THz Wave Emission under Double-Pulse Excitation of Thin Water Flow." Applied Sciences 10, no. 6 (2020): 2031. http://dx.doi.org/10.3390/app10062031.

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Simultaneous measurements of THz wave and hard X-ray emission from thin and flat water flow when irradiated by double femtosecond laser pulses (800 nm, 35 fs/transform-limited, 0.5 kHz, delay times up to 15 ns) were carried out. THz wave measurements by time-domain spectroscopy and X-ray detection by Geiger counters were performed at the transmission and the reflection sides of the flow. THz wave emission spectra show their dynamic peak shifts toward the low frequency with the highest intensity enhancements more than 1.5 × 10 3 times in |E| 2 accumulated over the whole spectrum range of 0–3 TH
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Neelakanta, Perambur. "de Novo Radio Frequency Ablation Therapy: Application of Unexplored Electromagnetic Spectral Resources of mm-Wave/THz Band in Clinical Ablation Procedures – A Review." British Journal of Medicine and Medical Research 3, no. 4 (2013): 1701–30. http://dx.doi.org/10.9734/bjmmr/2013/4368.

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Aşırım, Özüm Emre, Alim Yolalmaz, and Mustafa Kuzuoğlu. "High-Fidelity Harmonic Generation in Optical Micro-Resonators Using BFGS Algorithm." Micromachines 11, no. 7 (2020): 686. http://dx.doi.org/10.3390/mi11070686.

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Harmonic generation is an attractive research field that finds a variety of application areas. However, harmonic generation within a medium of micron-scale interaction length limits the magnitude of nonlinear coupling and leads to poor harmonic generation efficiency. In this study, we present a constrained non-linear programming approach based on the Quasi-Newton Broyden–Fletcher–Goldfarb–Shanno (BFGS) algorithm to obtain high-fidelity harmonic generation in optical micro-resonators. Using this approach, one can achieve high-intensity harmonic generation in a simple Fabry–Perot type optical mi
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Colangelo, Nicola, Stefano Benussi, Simona Nascimbene, et al. "Cardiopulmonary bypass strategy during concomitant surgical treatment of mitral valve disease and atrial fibrillation." Perfusion 18, no. 1 (2003): 19–24. http://dx.doi.org/10.1191/0267659103pf641oa.

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In recent years, the popularity of simplified intraoperative ablation approaches to treat atrial fibrillation (AF) has been progressively increasing. Our group has described a left atrial procedure based on epicardial radio frequency ablation on cardiopulmonary bypass (CPB). We report our CPB and myocardial protection strategy in 157 patients who underwent AF ablation combined with open-heart surgery from February 1998 to February 2002. Since epicardial ablations are performed on CPB on the beating heart, the CPB strategy is crucial. Total normothermic CPB allows a safe dissection around the p
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Zhang, Huazhong, Hongbiao Yin, Xia Lei, et al. "An Improved CNN-Based Algorithm for Quantitative Prediction of Impact Damage Depth in Civil Aircraft Composites via Multi-Domain Terahertz Spectroscopy." Electronics 14, no. 12 (2025): 2412. https://doi.org/10.3390/electronics14122412.

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To address the issue of low accuracy and stability in traditional Convolutional Neural Networks (CNN)-based defect depth prediction for civil aircraft composites, we propose an improved Feature Enhancement Network (FEN)-CNN-Bidirectional Long Short-Term Memory (BiLSTM) impact damage depth prediction method. By integrating terahertz (THz) time-domain, frequency-domain, and absorbance spectroscopy with Confocal Laser Scanning Microscopy (CLSM) depth measurements, the correlation between THz spectral features and impact damage defect depth is systematically elucidated, thereby constructing a “THz
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Simon, Alex, Connor Edsall, and Eli Vlaisavljevich. "Effects of pulse repetition frequency on bubble cloud characteristics and ablation for single-cycle histotripsy." Journal of the Acoustical Society of America 152, no. 4 (2022): A247. http://dx.doi.org/10.1121/10.0016161.

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Histotripsy is a cavitation-based focused ultrasound ablation method in development for multiple clinical applications. This work investigates the effects of pulse repetition frequency (PRF) on histotripsy bubble cloud characteristics and ablative capabilities for single cycle histotripsy. Bubble clouds produced by a 500 kHz histotripsy system at PRF’s from 0.1 to 1000 Hz were visualized using high speed imaging in 1% agarose phantoms. Cloud images were analyzed to determine bubble cloud density (bubbles/mm2) and pulse-to-pulse bubble correlation. Ablation was assessed through lesion analysis
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Raut, R., MB KC, S. Rajbhandari, M. Dhungana, R. Shah, and KB Shah. "Radio Frequency Ablation of right sided accessory pathway - 8 years experience at SGNHC." Nepalese Heart Journal 8, no. 1 (2013): 19–22. http://dx.doi.org/10.3126/njh.v8i1.8332.

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Background Radiofrequency ablation has been established as the curative treatment for most of supraventricular tachycardia since 1987. In SGNHC, ablation has been done routinely since 2003. In our experience, right sided accessory pathway (AP) has been technically difficult and challenging with low success rate as mentioned in literature outside. So, the objective of this article was to analyze the demographic characteristics, success and recurrence rate and complication of right sided AP ablation in our centre. Methods and Materials From 13th Oct 2003 to 9th Sept. 2011, altogether 768 patient
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Xu, B., Y. Ma, X. Yang, et al. "Effect of high-Z dopant on the laser-driven ablative Richtmyer–Meshkov instability." Laser and Particle Beams 35, no. 2 (2017): 366–72. http://dx.doi.org/10.1017/s0263034617000301.

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AbstractThe effects of high-Z dopant on the laser-driven ablative Richtmyer–Meshkov instability (RMI) are investigated by theoretical analysis and radiation hydrodynamics simulations. It is found that the oscillation amplitude of ablative RMI depends on the ablation velocity, the blow-off plasma velocity and the post-shock sound speed. Owing to enhancing the radiation at the plasma corona and increasing the radiation temperature at the ablation front, the high-Z dopant in plastic target can significantly increase the ablation velocity and the blow-off plasma velocity, leading to an increase in
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Severgin, Vladisav, Sergei Prohoda, and Aleksey Prohoda. "THE USE OF RADIO-FREQUENCY ABLATION IN THE TREATMENT OF MALIGNANT TUMORS OF LUNGS AND PLEURA." EUREKA: Health Sciences 3 (May 31, 2016): 31–35. http://dx.doi.org/10.21303/2504-5679.2016.00097.

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Aim of the work. Analysis of the possibilities of the different methods of RFA of lung and pleura tumors. Material and methods. There were considered the different methods of radio-frequency ablations using FOTEK-150 apparatus in 186 patients with the malignant tumors of lungs and pleura. Results. In the result of use of the different methods of radio-frequency ablation the direct positive effect was attained in 91 % of observations. The complications were observed in 9 % of patients. This method must be used for patients with the malignant tumors of lungs and pleura when the radical surgical
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Tuttle, Rebecca, Steven J. Nurkin, and Steven N. Hochwald. "Ablative Therapy for Esophageal Dysplasia and Early Malignancy: Focus on RFA." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/642063.

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Ablative therapies have been utilized with increasing frequency for the treatment of Barrett’s esophagus with and without dysplasia. Multiple modalities are available for topical ablation of the esophagus, but radiofrequency ablation (RFA) remains the most commonly used. There have been significant advances in technique since the introduction of RFA. The aim of this paper is to review the indications, techniques, outcomes, and most common complications following esophageal ablation with RFA.
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Landry, Thomas G., and Jeremy A. Brown. "Ultrasound imaging guided precision histotripsy: Effects of pulse settings on ablation properties in rat brain." Journal of the Acoustical Society of America 155, no. 4 (2024): 2860–74. http://dx.doi.org/10.1121/10.0025832.

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A high-frequency 6 MHz miniature handheld histotripsy device with an endoscopic form factor and co-registered high-resolution ultrasound imaging was developed. This device could allow precision histotripsy ablation during minimally invasive brain tumor surgeries with real-time image guidance. This study characterized the outcome of acute histotripsy in the normal in vivo rat brain using the device with a range of histotripsy pulse settings, including number of cycles, pulse repetition frequency, and pressure, as well as other experimental factors. The stability and shape of the bubble cloud we
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Murphy, Kelsey, Kenneth Aycock, Spencer Marsh, et al. "Abstract 4917: High-frequency irreversible electroporation ablation of glioma alters extracellular vesicles and disrupts the blood-brain barrier endothelium." Cancer Research 83, no. 7_Supplement (2023): 4917. http://dx.doi.org/10.1158/1538-7445.am2023-4917.

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Abstract High-frequency irreversible electroporation (H-FIRE) is a nonthermal tumor ablation technology that kills cancer cells via pulsed electric fields. H-FIRE has been shown to precisely and nonthermally ablate brain tumors while transiently disrupting the peritumoral blood-brain barrier (BBB). The enhanced BBB permeability post-tumor ablation can be exploited to enhance therapeutic delivery to invasive tumor margins, but the mechanisms of H-FIRE-induced BBB disruption remain incompletely characterized. We hypothesize that bystander effects of H-FIRE tumor cell ablation, specifically the r
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Siddiqui, Imran A., Russell C. Kirks, Eduardo L. Latouche, et al. "High-Frequency Irreversible Electroporation: Safety and Efficacy of Next-Generation Irreversible Electroporation Adjacent to Critical Hepatic Structures." Surgical Innovation 24, no. 3 (2017): 276–83. http://dx.doi.org/10.1177/1553350617692202.

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Irreversible electroporation (IRE) is a nonthermal ablation modality employed to induce in situ tissue-cell death. This study sought to evaluate the efficacy of a novel high-frequency IRE (H-FIRE) system to perform hepatic ablations across, or adjacent to, critical vascular and biliary structures. Using ultrasound guidance H-FIRE electrodes were placed across, or adjacent to, portal pedicels, hepatic veins, or the gall bladder in a porcine model. H-FIRE pulses were delivered (2250 V, 2-5-2 pulse configuration) in the absence of cardiac synchronization or intraoperative paralytics. Six hours af
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Butt, Usman Mahmood, Imran Saleem, Hafiz Abdul Mannan Shahid, Waqar Hassan, Muhammad Ashraf Dar, and Zubair Akram. "Evaluation of the Quantity and Duration of Junctional Rhythm during Successful Radiofrequency Ablation among Patients with Atrioventricular Nodal Re-Entry Tachycardia." Pakistan Heart Journal 56, no. 1 (2023): 56–60. http://dx.doi.org/10.47144/phj.v56i1.2368.

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Objectives: To evaluate the quantity and duration of junctional rhythm during radiofrequency ablation among atrioventricular nodal reentry tachycardia (AVRNT) patients. Methodology: A Cross sectional study was conducted at Punjab Institute of cardiology from May – July, 2022. Ablations of slow pathway were executed on 50 patients who fulfilled the inclusion criteria using ablation catheters of 4-mm tip. Power output was kept between 35- 40 Watt with a temperature control at 60 °C depending upon the occurrence of junctional rhythm. The target end points of radio frequency ablation (RFA) were in
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Yakushev, A. V., and O. Z. Paratsii. "Comparative characteristics of different methods of radiofrequency catheter ablation in atrial flutter." Zaporozhye Medical Journal 24, no. 5 (2022): 516–20. http://dx.doi.org/10.14739/2310-1210.2022.5.259489.

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Catheter ablation occupies the first place in the treatment of atrial macro reentry arrhythmias. The main controllable parameters in ablations are energy, duration of exposure and use of catheter tip cooling. With traditional ablation techniques, there is a high risk of insufficient tissue damage due to electrode instability. Regarding the issue of stability, a new technique was proposed – reducing the application time with increasing the energy. The aim of this work was to compare the results of radiofrequency catheter ablation (RFA) using an 8 mm uncooled electrode to a 4 mm cooled electrode
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Diaz, C., and J. C. Glover. "Appropriate pattern formation following regulative regeneration in the hindbrain neural tube." Development 122, no. 10 (1996): 3095–105. http://dx.doi.org/10.1242/dev.122.10.3095.

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Patterns of neuronal differentiation and axon outgrowth were examined in regenerated neural tissue of the hindbrain of the chicken embryo. Specific regions of the hindbrain neural tube corresponding to identified rhombomeres were selectively removed unilaterally by microsurgery. Of the embryos that survived, about 35% exhibited regulative regeneration, wherein the missing hemi-rhombomere was reconstituted to normal size and morphology through compensatory proliferation and migration from adjacent tissue. The capacity for regeneration depended on the embryonic stage at which the ablation was pe
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Slovak, Ryan, Junaid Raja, Meaghan Dendy Case, and Hyun S. Kim. "Interventional Oncology in Immuno-Oncology Part 1: Thermal Ablation." Digestive Disease Interventions 03, no. 02 (2019): 143–54. http://dx.doi.org/10.1055/s-0039-1679935.

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AbstractThermal ablation occupies a unique position among the various modalities available to treat malignancies. Initially utilized as a minimally invasive form of palliation, ablative techniques are increasingly being recognized for their role in activating an immune response. Locally destructive, but not thoroughly extirpative, thermal ablation function to generate an in situ tumor vaccine capable of stimulating and enhancing both innate and adaptive immune responses. As monotherapy, the response engendered remains therapeutically insufficient, but newer data suggests that when used as an a
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P., Naufal, Rinu Susan Thomas, and Lin Varghese. "CT Guided Microwave Ablation of Osteoid Osteoma – Efficacy in Alleviation of Symptoms." Journal of Evolution of Medical and Dental Sciences 10, no. 24 (2021): 1835–39. http://dx.doi.org/10.14260/jemds/2021/379.

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BACKGROUND Osteoid osteoma is a benign bone tumour which eventually undergoes spontaneous resolution but causes distress due to severe inflammatory pain and sleep loss. Major goal of ablative procedure is alleviation of symptoms. Long term follow up studies on pain remission and complications are less commonly available for microwave ablation. We wanted to assess alleviation of symptoms and long term complications in CT guided microwave ablation of osteoid osteoma. METHODS CT (Computed tomography) guided microwave ablation was performed on 10 patients referred with clinicoradiological diagnosi
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Col Sandip Kumar, Lt, Pavan Kumar Banga, and Col D K Khare. "Comparative Evaluation of Conventional Surgery with Radio Frequency Ablation in the Treatment of Varicose Veins." International Journal of Science and Research (IJSR) 11, no. 7 (2022): 1056–61. http://dx.doi.org/10.21275/mr22714004954.

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Jin, Xiaofei, Mengwei Jiang, Lu Qian, et al. "Effect of 433 MHz double-slot microwave antennas for double-zone ablation in ex vivo swine liver experiment." PLOS ONE 20, no. 2 (2025): e0315678. https://doi.org/10.1371/journal.pone.0315678.

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Purpose To evaluate the effects of axial length and slot-to-slot distance of double-slot microwave antenna (DSMA) with frequency of 433 MHz on the size and shape of ablation zones created under different input microwave powers. Materials and methods The design of double slot microwave antennas (DSMAs) with axial lengths (70 mm, 30 mm) and slot-to-slot distance (49 mm, 10 mm) were optimized by numerical simulation and ex vivo liver experiments. Finite-element method simulations and forty ablations of swine liver were employed to obtain the temperature distributions within liver tissue using DSM
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Mancia, Lauren, Eli Vlaisavljevich, Nyousha Yousefi, et al. "Focused ultrasound ablation of solid tumors: Feasibility of planning tissue-selective treatments." Journal of Clinical Oncology 38, no. 15_suppl (2020): e15600-e15600. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e15600.

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e15600 Background: Focused ultrasound (FUS) is a noninvasive, nonionizing, repeatable local ablative therapy that induces mechanical fractionation or thermal necrosis of a variety of solid tumors including hepatocellular carcinoma, prostate cancer, and desmoid fibromatosis. Recent feasibility studies in animal models have demonstrated the possibility of designing focused ultrasound treatments that are selective (e.g. spare healthy tissue, nerves, and blood vessels) due to differences in tissue and tumor mechanical properties. Given wide variation in individual tumor and patient characteristics
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Sánchez-Périz, Ixeia, Isabel Barrachina-Martínez, Javier Díaz-Carnicero, Andreu M. Climent, and David Vivas-Consuelo. "Cost-Effectiveness Mathematical Model to Evaluate the Impact of Improved Cardiac Ablation Strategies for Atrial Fibrillation Treatment." Mathematics 11, no. 4 (2023): 915. http://dx.doi.org/10.3390/math11040915.

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Atrial fibrillation (AF) is the most common form of cardiac arrhythmia. Despite the frequency of the disease, the treatment strategies for AF are inefficient. We developed a cost-effectiveness model to evaluate potential improvements in the application of cardiac ablations to treat AF. These are surgical procedures to terminate the arrhythmia and restore Sinus Rhythm. A Markov Model with a time horizon of five years was built to represent the management of patients in AF. A Montecarlo simulation was developed as a sensitivity analysis when the effectiveness increases the estimate of the potent
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Fadare, Oluwole, Lihui Qin, Maritza Martel, and Fattaneh A. Tavassoli. "Pathology of the NovaSure (Radio-Frequency) Impedance-Controlled Endometrial Ablation System." Archives of Pathology & Laboratory Medicine 129, no. 9 (2005): 1175–78. http://dx.doi.org/10.5858/2005-129-1175-potnri.

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Abstract The widespread use of increasingly novel diagnostic and neoadjuvant therapeutic modalities necessitates that contemporary pathologists familiarize themselves with the spectrum of tissue derangements that may be seen in the eventual surgical specimens. In the management of endometrial lesions, for example, a variety of endometrial ablation technologies, such as cryosurgery, balloon therapy, microwave, hot circulating saline, and bipolar impedance technology, have been introduced in the past decade and are being utilized with increasing frequency. We describe herein pathologic changes a
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Cincotta, Robert, and Sailesh Kumar. "Future Directions in the Management of Twin-to-Twin Transfusion Syndrome." Twin Research and Human Genetics 19, no. 3 (2016): 285–91. http://dx.doi.org/10.1017/thg.2016.32.

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Twin-to-twin transfusion syndrome (TTTS) is the major complication of monochorionic (MC) pregnancy. The outcomes of this condition have been significantly improved after the introduction and widespread uptake of fetoscopic laser ablation over the last decade. However, there is still a significant fetal loss rate and morbidity associated with this condition. Improvements in the management of TTTS will require improvements in many areas. They are likely to involve refinements in the prediction of the disease and clarification of the optimum frequency of surveillance and monitoring. Improvements
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Radros, Jari, Anders Kjellman, Lars Henningsohn, et al. "Ablative or Surgical Treatment for Small Renal Masses (T1a): A Single-Center Comparison of Perioperative Morbidity and Complications." Current Oncology 31, no. 2 (2024): 933–40. http://dx.doi.org/10.3390/curroncol31020069.

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The purpose of this study is to evaluate the treatment safety of thermal ablation compared to surgical treatment of T1a tumors (small renal masses) at a high-volume center. We conducted an observational single-center study based on data collected form the National Swedish Kidney Cancer Register (NSKCR) between 2015 and 2021. In total, 444 treatments of T1a tumors were included. Patients underwent surgery (partial or total nephrectomy) or ablative treatment—radiofrequency ablation (RFA) or microwave ablation (MWA). Patient characteristics were retrieved from patient records, and tumor complexit
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Lorenzo, Melvin F., Sabrina N. Campelo, Julio P. Arroyo, et al. "An Investigation for Large Volume, Focal Blood-Brain Barrier Disruption with High-Frequency Pulsed Electric Fields." Pharmaceuticals 14, no. 12 (2021): 1333. http://dx.doi.org/10.3390/ph14121333.

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The treatment of CNS disorders suffers from the inability to deliver large therapeutic agents to the brain parenchyma due to protection from the blood-brain barrier (BBB). Herein, we investigated high-frequency pulsed electric field (HF-PEF) therapy of various pulse widths and interphase delays for BBB disruption while selectively minimizing cell ablation. Eighteen male Fisher rats underwent craniectomy procedures and two blunt-tipped electrodes were advanced into the brain for pulsing. BBB disruption was verified with contrast T1W MRI and pathologically with Evans blue dye. High-frequency irr
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Amiegbereta, Edwin Ehis, Ayo Zacchaeus Ibitoye, and Oghenevovwero Emmanuel Esi. "Computational Analysis of a Suitable Antenna and Optimized Frequency for Microwave Ablation of Breast Cancerous Tissue." medtigo Journal of Medicine 2, no. 3 (2024): e13752246. https://doi.org/10.63096/medtigo3062249.

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The study was aimed to simulate and analyze a suitable antenna operating at an optimized frequency for microwave ablation of breast cancerous tissue. Four different antennas were simulated and analyzed using finite element method (FEM) software. Based on the variation in their reflection coefficient, total power density, and Specific Absorption Ratio, three of the antennas were selected. The four antennas have different geometry parameters based on the effective wavelength in breast tissue at the variable frequencies. Power loss for all simulated microwave antennas were above 50 % from an inpu
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Demarchi, Andrea, Matteo Casula, Ginevra Annoni, Marco Foti, and Roberto Rordorf. "Catheter Ablation of Atrial Fibrillation in Patients with Heart Failure: Focus on the Latest Clinical Evidence." Journal of Clinical Medicine 13, no. 17 (2024): 5138. http://dx.doi.org/10.3390/jcm13175138.

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Atrial fibrillation and heart failure are two common cardiovascular conditions that frequently coexist, and it has been widely demonstrated that in patients with chronic heart failure, atrial fibrillation is associated with a significant increase in the risk of all-cause death and all-cause hospitalization. Nevertheless, there is no unanimous consensus in the literature on how to approach this category of patients and which therapeutic strategy (rhythm control or frequency control) is the most favorable in terms of prognosis; moreover, there is still a lack of data comparing the different abla
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I.Z., Gladchuk, Gladchuk I.Z., and Kashtalian N.M. "Analysis of the results of combined treatment of cervix precancerous pathology in reproductive aged women." REPRODUCTIVE ENDOCRINOLOGY, no. 58 (May 27, 2021): 83–88. https://doi.org/10.18370/2309-4117.2021.58.83-88.

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<strong>Aim of the study.</strong>&nbsp;Comparative analysis of the results of cervical epithelial neoplasia (CIN) I and II levels (p16ink4a-negative) (LSIL in LAST terminology) treatment against the background of highly oncogenic HPV infection using cold plasma ablation and immunomodulatory therapy with Аllokin-alpha. <strong>Materials and methods.</strong>&nbsp;We examined 60 women who received treatment for CIN I and CIN II (p16ink 4A negative) at the Multidisciplinary Medical Center of Odessa National Medical University. All women were of reproductive age, had mild dysplasia, high-risk HPV
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An, Jinsu, Dong-Sung Won, Yubeen Park, et al. "Effects of changes in the waveform and frequency of radio frequency energy on tissue ablation range." PLOS ONE 19, no. 9 (2024): e0308691. http://dx.doi.org/10.1371/journal.pone.0308691.

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This study reports the effects of changes in the waveform and frequency of radio frequency (RF) energy on the tissue ablation range. We developed a 70-watt RFA generator that provides sine and square waves and allows frequency control between 10 Hz and 500 kHz. The changes in the ablation range according to the waveform and frequency were observed using the developed generator. In the waveform variation test, the distance between the electrodes and the electrode type were changed for both waveforms with the frequency set to 500 kHz. In the frequency variation test, the waveform and electrode t
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FARAJIAN, REZA, MARY A. RAVEN, KAREN CUSATO, and BENJAMIN E. REESE. "Cellular positioning and dendritic field size of cholinergic amacrine cells are impervious to early ablation of neighboring cells in the mouse retina." Visual Neuroscience 21, no. 1 (2004): 13–22. http://dx.doi.org/10.1017/s0952523804041021.

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We have examined the role of neighbor relationships between cholinergic amacrine cells upon their positioning and dendritic field size by producing partial ablations of this population of cells during early development. We first determined the effectiveness ofl-glutamate as an excitotoxin for ablating cholinergic amacrine cells in the developing mouse retina. Subcutaneous injections (4 mg/g) made on P-3 and thereafter were found to produce a near-complete elimination, while injections at P-2 were ineffective. Lower doses on P-3 produced only partial reductions, and were subsequently used to ex
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Vogel, Jantien A., Eran van Veldhuisen, Lindy K. Alles, et al. "Time-Dependent Impact of Irreversible Electroporation on Pathology and Ablation Size in the Porcine Liver: A 24-Hour Experimental Study." Technology in Cancer Research & Treatment 18 (January 1, 2019): 153303381987689. http://dx.doi.org/10.1177/1533033819876899.

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Irreversible electroporation causes cell death through low frequency, high voltage electrical pulses and is increasingly used to treat non-resectable cancers. A recent systematic review revealed that tissue damage through irreversible electroporation is time-dependent, but the impact of time on the ablation zone size remains unknown. Irreversible electroporation ablations were performed hourly during 24 consecutive hours in the peripheral liver of 2 anaesthetized domestic pigs using clinical treatment settings. Immediately after the 24th ablation, the livers were harvested and examined for tis
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Miaskowski, Arkadiusz, and Piotr Gas. "Numerical Estimation of SAR and Temperature Distributions inside Differently Shaped Female Breast Tumors during Radio-Frequency Ablation." Materials 16, no. 1 (2022): 223. http://dx.doi.org/10.3390/ma16010223.

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Radio-frequency (RF) ablation is a reliable technique for the treatment of deep-seated malignant tumors, including breast carcinoma, using high ablative temperatures. The paper aims at a comparative analysis of the specific absorption rate and temperature distribution during RF ablation with regard to different female breast tumors. In the study, four tumor models equivalent to an irregular tumor were considered, i.e., an equivalent sphere and ellipsoid with the same surfaces and volumes as the irregular tumor and an equivalent sphere and ellipsoid inscribed in the irregular tumor. An RF appli
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Campbell, Matthew T., Surena F. Matin, Rebecca Slack, et al. "Ablative therapy to induce local and systemic immune changes in patients with metastatic renal cell carcinoma." Journal of Clinical Oncology 35, no. 6_suppl (2017): 505. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.505.

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505 Background: Ablative therapy including cryoablation or radiofrequency ablation is a therapeutic option for small renal cell carcinomas (RCC) and provides effective palliation for symptomatic metastatic lesions, with reports of associated abscopal phenomenon in small numbers of patients. Pre-clinical animal modeling has suggested potential synergy with the use of ablative therapy and immune checkpoint blockade with ipilimumab. Methods: We performed retrospective analysis of 17 patients who underwent an ablative procedure followed later by nephrectomy. These samples were analyzed by IHC and
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Gladchuk, I. Z., I. Z. Gladchuk, and N. M. Kashtalian. "Analysis of the results of combined treatment of cervix precancerous pathology in reproductive aged women." Reproductive Endocrinology, no. 58 (May 27, 2021): 83–88. http://dx.doi.org/10.18370/2309-4117.2021.58.83-88.

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Aim of the study. Comparative analysis of the results of cervical epithelial neoplasia (CIN) I and II levels (p16ink4a-negative) (LSIL in LAST terminology) treatment against the background of highly oncogenic HPV infection using cold plasma ablation and immunomodulatory therapy with Аllokin-alpha.Materials and methods. We examined 60 women who received treatment for CIN I and CIN II (p16ink 4A negative) at the Multidisciplinary Medical Center of Odessa National Medical University. All women were of reproductive age, had mild dysplasia, high-risk HPV infection (HPV 16, 18, 31, 45) and histologi
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Dahlvang, James D., Jules A. Sangala, and Geoffrey T. Hart. "Using CRISPR/cas9 in primary natural killer cells to study antibody dependent cellular cytotoxicity signaling." Journal of Immunology 206, no. 1_Supplement (2021): 97.14. http://dx.doi.org/10.4049/jimmunol.206.supp.97.14.

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Abstract In contrast to conventional natural killer (NK) cells, adaptive NK cells lack expression of the Fc receptor γ chain and transcription factor PLZF. A higher proportion of adaptive NK cells is correlated with protection from malaria. Adaptive NK cells have shown enhanced degranulation in response to opsonized targets, as measured by CD107A and interferon-γ (IFN-γ) expression. We hypothesize that people with a higher frequency of adaptive NK cells are protected from malaria because of the enhanced degranulation of adaptive NK cells. However, it is unclear why adaptive NK cells degranulat
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Jacobs, Ira A., C. K. Chang, and George Salti. "Hepatic Radio frequency Ablation of Metastatic Ovarian Granulosa Cell Tumors." American Surgeon 69, no. 5 (2003): 416–18. http://dx.doi.org/10.1177/000313480306900511.

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Intrahepatic recurrences of a granulosa cell tumor of the ovary after primary resection has traditionally been considered a relative contraindication to surgical management. Improvements in ablative technologies such as radiofrequency ablation (RFA) offer the surgeon additional alternatives in the management of selected intrahepatic tumors. We present a case report of an intrahepatic recurrence of a metastatic ovarian granulosa cell tumor 6 months after primary resection. The patient received RFA of the intrahepatic lesions and the patient remains free of detectable disease 14 months later. A
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Horikawa, J., and N. Suga. "Biosonar signals and cerebellar auditory neurons of the mustached bat." Journal of Neurophysiology 55, no. 6 (1986): 1247–67. http://dx.doi.org/10.1152/jn.1986.55.6.1247.

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In the vermis (VIp, VIIa, VIIp, and VIII), crus, and paraflocculus of unanesthetized mustached bats Pteronotus parnellii parnellii, responses of single neurons to acoustic stimuli were studied. The stimuli delivered were constant-frequency (CF) tones, frequency-modulated (FM) sounds, noise bursts (NBs), and sounds similar to the orientation sounds (pulses) of the species and echoes. The effect of ablation of the cerebellar cortex on vocalization was also investigated to explore whether the cerebellum was involved in sound emission. In the cerebellum of the mustached bat, auditory neurons are p
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Nidhi, Kamra, Goyal Pallavi, and Arora Aakanksha. "Trichloroacetic Acid 90% versus Radiofrequency Ablation in the Management of Facial Seborrheic Keratoses: A Prospective Interventional Study." International Journal of Pharmaceutical and Clinical Research 16, no. 10 (2024): 1330–34. https://doi.org/10.5281/zenodo.14464082.

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<strong>Introduction:</strong>&nbsp;Seborrheic Keratoses (SK) are commonly encountered benign epidermal tumors characterized by well-demarcated, skin coloured to brown or black coloured, slightly elevated papules or plaques. Facial involvement is often associated with cosmetic concerns in patients.&nbsp;<strong>Aims and Objectives:</strong>&nbsp;The aim of this study was to compare the efficacy and safety profile of RF ablation with 90% TCA for the treatment of facial SK.&nbsp;<strong>Materials &amp; Methods:</strong>&nbsp;A total of 80 cases of facial seborrheic keratosis were included in the
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Hutson, K. A., and R. B. Masterton. "The sensory contribution of a single vibrissa's cortical barrel." Journal of Neurophysiology 56, no. 4 (1986): 1196–223. http://dx.doi.org/10.1152/jn.1986.56.4.1196.

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The sensory contribution of the cortex containing the cortical barrel of the C1 vibrissa was studied in rats using the ablation-behavior method. Three independent experiments were performed, each requiring stimulus transduction by the C1 vibrissa but varying in their perceptual demands. The first required detection of sinusoidal oscillations of the vibrissa generated by an oscillating airstream directed vertically onto the vibrissa tip. The second required detection of a change in rate of the oscillation. The third required the blinded rat to jump a gap in an elevated runway after palpating th
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Siribumrungwong, Boonying, Kanoklada Srikuea, Saritphat Orrapin, Thoetphum Benyakorn, Kittipan Rerkasem, and Ammarin Thakkinstian. "Endovenous ablation and surgery in great saphenous vein reflux: a systematic review and network meta-analysis of randomised controlled trials protocol." BMJ Open 9, no. 1 (2019): e024813. http://dx.doi.org/10.1136/bmjopen-2018-024813.

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IntroductionEndovenous ablations are the new standard procedures for treatment of great saphenous vein reflux including endovenous laser ablation (EVLA), radio frequency ablation (RFA), endovenous steam ablation (EVSA), mechanochemical ablation (MOCA), cyanoacrylate injection and ultrasound-guided foam sclerotherapy (UGFS). EVLA and RFA have demonstrated similar anatomical success for short-term outcome, but results are controversial for longer term (≥5 years). Additional evidences from randomised controlled trials have been published. This study is, therefore, conducted to, directly and indir
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Petrov, E. S., A. N. Volobuev, M. S. Khokhlunov, and M. M. Mazilov. "EXTERNAL RADIO-FREQUENCY DENERVATION OF RENAL ARTERIES." Science and Innovations in Medicine 1, no. 4 (2016): 69–72. http://dx.doi.org/10.35693/2500-1388-2016-0-4-69-72.

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Aim - study of renal arteries denervation for the surgical treatment of primary arterial hypertension. Materials and methods. Radio-frequency ablation from the side of artery adventitia was carried out on preparations of the renal arteries. Results. The study determined comprehensible regimes of radio-frequency ablation, not resulting in a large degradation of the renal arteries strength properties, but providing reliable denervation of these arteries. Micro-photos of the renal artery wall after carrying out radio-frequency ablation were obtained. Conclusion. It is shown that the most comprehe
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Bartoș, Adrian, Dana Bartos, Zeno Spârchez, et al. "Laparoscopic Contrast-Enhanced Ultrasonography for Real Time Monitoring of Laparoscopic Radiofrequency Ablation for Hepatocellular Carcinoma: an Observational Pilot Study." Journal of Gastrointestinal and Liver Diseases 28, no. 4 (2019): 457–62. http://dx.doi.org/10.15403/jgld-263.

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Background and Aims: Laparoscopic radio-frequency ablation (L-RFA) for hepatocellular carcinoma (HCC) is used for unresectable tumors, with difficult location, unfitted for a percutaneous ablation technique. L-RFA has a high incidence of local recurrence. Even if intraoperative-ultrasound is standardized for staging and RFA probe guidance, the role of laparoscopic contrast-enhanced ultrasound (L-CEUS) for the real time monitoring of L-RFA efficacy has not been previously reported. We evaluated in a pilot observational study the efficacy of L-CEUS to assess the necrotic post-ablative area in di
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Rav Acha, Moshe, Oholi Tovia-Brodie, Yoav Michowitz, et al. "Cryoballoon-Induced Circumferential Pulmonary Vein Fibrosis, Assessed by Late Gadolinium-Enhancement Cardiac Magnetic Resonance Imaging, and Its Correlation with Clinical Atrial Fibrillation Recurrence." Journal of Clinical Medicine 12, no. 6 (2023): 2442. http://dx.doi.org/10.3390/jcm12062442.

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Background: Prior studies evaluating post-atrial fibrillation (AF) ablation pulmonary vein (PV) ostial gaps via magnetic resonance imaging (MRI) have shown circumferential PV fibrosis in a minority of patients, and their correlation with AF recurrence was weak. These studies were mostly based on radio-frequency AF ablations. Aim: We aimed to assess cryoballoon ablation-induced PV fibrosis via MRI and its correlation with AF recurrence. Methods and Results: This was a prospective study of consecutive patients with symptomatic AF who underwent pre- and post-ablation MRI to assess baseline and ab
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Ezzat, Vivienne A., Matthew J. Ryan, Justin O’Leary, et al. "Radiofrequency ablation of atrial tachyarrhythmias in adults with tetralogy of Fallot – predictors of success and outcome." Cardiology in the Young 27, no. 2 (2016): 284–93. http://dx.doi.org/10.1017/s1047951116000482.

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AbstractBackgroundAdults with tetralogy of Fallot experience atrial tachyarrhythmias; however, there are a few data on the outcomes of radiofrequency ablation. We examined the characteristics, outcome, and predictors of recurrence of atrial tachyarrhythmias after radiofrequency ablation in tetralogy of Fallot patients.Methods/resultsRetrospective data were collected from 2004 to 2013. In total, 56 ablations were performed on 37 patients. We identified two matched controls per case: patients with tetralogy of Fallot but no radiofrequency ablation and not known to have atrial tachyarrhythmias. A
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Zagoria, Ronald J., Y. M. Michael, Perry Shen, and Edward A. Levine. "Complications from Radio frequency Ablation of Liver Metastases." American Surgeon 68, no. 2 (2002): 204–9. http://dx.doi.org/10.1177/000313480206800221.

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The objective of this study is to evaluate complications from radiofrequency ablation of liver metastases. Eighty-one liver tumors in 38 consecutive patients were treated with radiofrequency ablation. All patients had one to six metastases treated in a single session. Eight patients underwent radiofrequency ablation intraoperatively after laparotomy and the remaining 30 patients were treated percutaneously with CT or ultrasound guidance. A total of 43 radiofrequency ablation procedures were studied. There was one (2%) mortality related to a hepatic abscess development 8 days after the procedur
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Neelakanta, Perambur S., and Bharti Sharma. "de Novo Radio Frequency Ablation Therapy: Application of Unexplored Electromagnetic Spectral Resources of mm-Wave/THz Band in Clinical Ablation Procedures - A Review." June 3, 2013. https://doi.org/10.5281/zenodo.7998.

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Review Focus: General considerations on ablation procedure advocated in clinical contexts using electromagnetic (EM) energy are comprehensively reviewed. Relevant radiofrequency (RF) and/or microwave ablation techniques that have been in vogue and in traditional use across clinical procedures are revisited. Traditionally, RF/microwave ablations have been applied to a variety of pathological states, (in lieu of surgical methods and/or electrocautry procedures) so as to remove unwanted/cancerous tissue layers. Relevantly, new avenues of adopting unexplored electromagnetic (EM) energy falling in
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Gaudiuso, Caterina, Pavel N. Terekhin, Annalisa Volpe, Stefan Nolte, Bärbel Rethfeld, and Antonio Ancona. "Laser ablation of silicon with THz bursts of femtosecond pulses." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-92645-7.

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AbstractIn this work, we performed an experimental investigation supported by a theoretical analysis, to improve knowledge on the laser ablation of silicon with THz bursts of femtosecond laser pulses. Laser ablated craters have been created using 200 fs pulses at a wavelength of 1030 nm on silicon samples systematically varying the burst features and comparing to the normal pulse mode (NPM). Using bursts in general allowed reducing the thermal load to the material, however, at the expense of the ablation rate. The higher the number of pulses in the bursts and the lower the intra-burst frequenc
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Gao, Feilong, Shaodong Hou, Guoru Li, and Bingyuan Zhang. "THz active modulation device by electric field turned modulation characteristics of titanium sulfide nanofilm device." Microwave and Optical Technology Letters 66, no. 4 (2024). http://dx.doi.org/10.1002/mop.34130.

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AbstractAn effective approach to manipulate terahertz (THz) waves involves the utilization of a device structure. In this particular investigation, we have successfully fabricated a SnS2 nanofilm device using femtosecond laser direct ablation. The passive and active polarization‐sensitive characteristics of the SnS2 nanofilm device were examined within the THz frequency range, employing different line spaces of 500, 600, and 700 μm. The combination of the device effect and SnS2 absorption led to an enhanced passive polarization modulation. Moreover, when an external electric field was applied
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