Journal articles on the topic 'Ti yu'

Pei-yu chi [Journey to the North] is a late Ming novel, which since Ch'ing dynasty times has usually been published together with three other short novels, namely Nanyu chi [Journey to the South], Tung-yu chi [Journey to the East], and Hsi-yu chi [Journey to the West], as a composite edition entitled Ssu-yu chi [The Four Journeys]. Authorship of Pei-yu chi is usually attributed to a certain Yü Hsiang-tou, but the work is popularly regarded as the mythic charter of divinity of the Emperor of the Dark Heavens (Hsüan-t'ien Shang-ti), apotheosis of the north. Arguments based on analogy with present-day religious practices on Taiwan, as well as the content and structure of Pei-yu chi, are used to support a theory that the text was originally composed as a religious tract (shan-shu) by Chinese spirit-medium cults.

ABSTRACT Improved superelastic Ti-Ni alloy wire (ISW) was used for the management of a 24-year-old patient presenting with facial asymmetry and maxillary and mandibular anterior dental crowding. After the extraction of teeth #14, #24, #34, #45, ISW leveling was performed to relieve upper and lower anterior crowding. Elastic chain and intermaxillary elastics (IME) were then used to correct the mandibular shift. The correction of facial asymmetry was successfully achieved within 31 months. The outcome was the accomplishment of an esthetic smiling arc that achieved patient satisfaction after the completion of orthodontic treatment. How to cite this article Yuan-Chieh C, Jian-Hong YU, Ya-Yu T, Chien-Chih YU. ISW for the Treatment of Adult Facial Asymmetry and Tooth Crowding. Int J Experiment Dent Sci 2013;2(2):134-138.

Nonlinear decay of an ordinary electromagnetic pump wave into an electro-acoustic wave and an upper-hybrid wave in a two-electron-temperature plasma has been investigated analytically. In contrast with the work of Sharma, Ramamurthy & Yu (1984), it is found that the decay can take place in the absence of the restrictive condition Ti ≫ Te and the plasma be magnetized. Using a hydrodynamical model of the plasma, the nonlinear dispersion relation and growth rate are obtained. A comparison of the present investigation is made with earlier work, and its possible application to the ELMO bumpy torus is discussed.

Методом ионно-лучевого распыления двух мишеней (одна из сплава CoFeB, вторая из TiO2) на вращающуюся ситалловую подложку получена серия образцов с градиентом состава и толщины композита (CoFeB)x(TiO2)1–x. На дифрактограммах aморфных композитов обнаружено гало, соответствующее среднему межатомному расстоянию, близкому по величине к значениям межплоскостных расстояний самых интенсивных дифракционных линий в сплавах CoFe. Методом ИК-спектроскопии проведена идентификация мод, соответствующих межатомным связям в аморфных композитах (CoFeB)x(TiO2)1–x различного состава. Установлено наличие связей с кислородом всех элементов композита Fe–O, Co–O, Ti–O, B-O, а также образование промежуточных химических связей Ti–O–B, Ti–O–Co между атомами диэлектрической и металлической компонент композита. На основе полученных данных предложена модель аморфных композитов (Co45Fe45B10)x(TiO2)1–x, в которой металлические частицы представляются в виде ядра из металлических кластеров CoFe с оболочкой из оксидов и боридов/оксиборидов d-металлов, распределенных в диэлектрической матрице диоксида титана TiO2–х.
 
 ИСТОЧНИК ФИНАНСИРОВАНИЯРабота выполнена при поддержке Минобрнауки России в рамках государственного заданияВУЗам в сфере научной деятельности на 2017–2019 годы. Проект № 3.6263.2017/ВУ.
 
 
 
 REFERENCES 
 
 Zolotukhin I. V., Kalinin Yu. E., Stognay O. V. New directions of physical materials science. Voronezh, Voronezh State University Publ., 2000, 456 p. (in Russ.)
 Gridnev S. A., Kalinin Yu. E., Sitnikov A. V., Stognay O.V. Nonlinear phenomena in nano- and microheterogeneous systems. Moscow, BINOM. Lab knowledge Publ., 2012, 352 p. (in Russ.)
 Stognay O. V. Electric transport and magnetic properties of amorphous nano-granulated metal-dielectric composites. Doc. Sci. diss, Voronezh, 2004, 280 p.
 Diany B., Serious V.S., Metin, Parkin S., Gurney B. A., Baumgart P., Wilhoit D. R. Magnetotransport properties of magnetically soft spin-valve structures. J. Appl. Phys., 1991, v. 69(9), pp. 4774–4779. https://doi.org/10.1063/1.348252
 Kalinin Yu. E., Sitnikov A. V., Stognei O. V., Zolotukhin I.V., Neretin P.V. Electrical properties and giant vagnetoresistance of the CoFeB–SiO2 amorphous granular composites. Materials Science and Engineering: A, 2001, v. 304–306, pp. 941–945. https://doi.org/10.1016/s0921-5093(00)01606-3
 Kotov L. N., Turkov V. K., Vlasov V. S., Lasek M. P., Kalinin Yu. E., Sitnikov A. V. Conductive, magnetic and structural properties of multilayer fi lms. IOP Conf. Series: Materials Science and Engineering, 2013, v. 47. 012027. https://doi.org/10.1088/1757-899X/47/1/012027
 Domashevskaya E. P., Storozhilov S. A., Turishchev S. Yu., Kashkarov V. M., Terekhov V. A., Stogney O. V., Kalinin Yu. E., Sitnikov A. V., Molodtsov S. L. XANES and USXES studies of interatomic interactions in (Co41Fe39B20)x(SiO2)1−x nanocomposites. Physics of the Solid State, 2008, v. 50(1), pp. 139–145. https://doi.org/10.1134/S1063783408010253
 Shchekochikhin A. V., Domashevskaya E. P., Karpov S. I. Effect of elemental composition based on CoFeB-SiO2 on magnetic and magnetoresistive properties. Kondensirovannye sredy i mezhfaznye granitsy [Condensed Matter and Interphases], 2006, v. 8(1), pp. 64–66. URL: http://www.kcmf.vsu.ru/resources/t_08_1_2006_013.pdf (in Russ.)
 Domashevskaya E. P., Chan Van Tu, Chernyshev A. V., Lukin A. N. Investigation of the interato mic interaction in multilayer nanostructures (Co45Fe45Zr10/a-Si)40 and (Co45Fe45Zr10/SiO2) by method of IR-spectroscopy and small angle diffraction. Condensed Matter and Interphases, 2017, v. 19(2), pp. 195–204. https://doi.org/10.17308/kcmf.2017.19/192 (in Russ.)
 JCPDS − International Centrefor Diffraction Data. 2001, no. 51−0740.
 JCPDS − International Centre for Diffraction Data. 2001, no. 49−1588.
 JCPDS − International Centre for Diffraction Data. 2001, no. 48−1817.
 Kongfa Chen, Lihua Fang, Teng Zhang, San Ping Jiang. New zinc andbismuth doped glass sealants with substantially suppressed borondeposition and poisoning for solid oxide fuel cells. J. Mater. Chem. A, 2014, v. 2(43), pp. 18655–18665. https://doi.org/10.1039/c4ta02951h
 Wenjie Zhang, Bo Yang, Jinlei Chen. Effects of calcination temperature on preparation of borondoped TiO2 by sol-gel method. International Journal of Photoenergy, 2012, v. 2012, pp. 1–8. https://doi.org/10.1155/2012/528637
 Rihcard A., Nyquistand R., Kagel O. Infrared Spectra of Inorganic Compounds. New York and London, Academic Press, 1971, 499 p.
 Milovanov Yu. S., Kuznetsov G. V., Skryshevsky V. A., Stupan S. M. Transport of Charge in Nanocomposite Structures of Silicon-SiO2, Silicon-TiO2. Semiconductors, 2014, v. 48(10), pp. 1335–1341. https://doi.org/10.1134/s1063782614100200
 Chetverikova A. G., Maryakhina V. S. Studies of polymineral clay containing three-layer aluminosilicates by physical methods. Bulletin of the Orenburg State University, 2015, no. 1 (176), pp. 250–255. (in Russ.)
 Shchekochikhin A. V., Domashevskaya E. P., Karpov S. I., Stognei O. V. Interatomic interaction and modes of IR spectra in amorphous nanocomposites (Co45Fe45Zr10)x(SiO2)1–x. Proceedings of Voronezh State University. Series: Physics. Mathematics, 2008, no. 1, pp. 109–114. URL: http://www.vestnik.vsu.ru/pdf/physmath/2008/01/schekochihin.pdf (in Russ.)
 María E., Pérez Bernal, Ricardo J., Ruano Casero, Vicente Rives. Mixed Oxides Co-Fe Mixed Oxides & Calorie/Calcination of Layered Double. Ceramics– Silikáty, 2004, v. 48(4), pp. 145–154. URL: https://www.irsm.cas.cz/materialy/cs_content/2004/Bernal_CS_2004_0000.pdf
 Nicholas T. Nolan, Michael K. Seery, Suresh C. Pillai. Spectroscopic investigation of the anatase-torutile transformation of sol-gel synthesised TiO2 photocatalysts // J. of Physical Chemistry C, 2009, v. 113, pp. 16151–16157. https://doi.org/10.1021/jp904358g
 

ABSTRACT A 19-year-old female came to our department with the chief complaint of facial asymmetry. Clinical examination showed skeletal class III relationship with mandibular prognathism, large reverse overjet, lower right mild crowding, and left hemimandibular elongation. After a thorough discussion with the patient, she accepted the proposal of orthognathic surgery and mandibular setback by bilateral sagittal split osteotomy (BSSRO), and therefore, tooth extraction was performed for 18, 28, 38, and 48 before the surgery. An improved superelastic Ti-Ni alloy wire (ISW wire), developed by Tokyo Medical and Dental University, was then used to facilitate the correction of lower crowding. Involved mechanism included intermaxillary elastics for a better interdigitation and jaw relationships. Adequate overbite and overjet were achieved after treatment completion. How to cite this article Fang C-Y, Tsai Y-Y, Yu J-H. Improved Superelastic NiTi wire for the Treatment of Adult Skeletal Class III Malocclusion in a Surgery-first Case. Int J Experiment Dent Sci 2016;5(2):133-138.

Hard and adherent wear-resistant thin surface coatings are synthesized on an aerospace alloy AA2219-T6 alloy using plasma-assisted physical vapor deposition. Submicron size TiN coatings with Ti interlayers are deposited and evaluated as a function of different deposition temperatures varying from 100 °C to 200 °C. Features of deposited surface layers are evaluated using different techniques; these include field emission scanning electron microscopy equipped with energy dispersive spectroscopy and X-ray diffraction. Mathematical models developed by Yu. A. Bykov and S. Hogmark are considered to estimate the coating thickness using the Composite Hardness measurements. The values predicted by Bykov’s model grossly underestimated the thickness values and thus a correction factor is proposed. The actual coating thickness is measured by sandwiching the thin coating between the substrate and electrolytically deposited nickel layer; the observations are made using field emission scanning electron microscope. The present study successfully used corrected Bykov’s Model along with micro-indentation proved to be an easy, quick and accurate method to estimate the coating thicknesses of thin hard coatings on the soft substrate over a wide range coating thicknesses.

Целью статьи является разработка феноменологической математической модели формирования и роста фаз в части влияния температурной зависимости параметров диффузии на характер роста слоев в двухкомпонентной многофазной системе. Темой исследования является анализ влияния температурной зависимости параметров диффузии на изменение характера роста слоев в двухкомпонентных многофазных системах. Предложено решение задачи использования температурного режима процесса диффузии при разработке технологических процессов сварки, пайки, нанесении покрытий и других, при которых в диффузионной зоне образуются интерметаллические слои, карбиды, нитриды, субоксиды, фосфиды и т. п. с заданными и контролируемыми эксплуатационными характеристиками получаемых новых материалов, их соединений, покрытий и пр. Результаты решения задачи позволяют по известным параметрам температурного режима процесса диффузии, полученным при исследовании двухкомпонентной многофазной системы, целенаправленно контролировать динамику роста, состав образующихся в процессе диффузии слоев, и их выходные параметры в данной системе для получения новых материалов с заданными свойствами.
 
 
 
 REFERENCES
 
 Molokhina L. A., Rogalin V. E., Kaplunov I. A., Filin S. A. Mathematical model for the growth of phases in binary multiphase systems upon isothermic annealing. Russian Journal of Physical Chemistry A, 2017, v. 91(9), pp. 1635-1641. https://doi.org/10.7868/S0044453717090242
 Molokhina L. A., Rogalin V. E., Kaplunov I. A., Filin S. A. Dependence of growth of the phases of multiphase binary systems on the diffusion parameters. Russian Journal of Physical Chemistry A, 2017, v. 91(12), pp. 2302–2309. https://doi.org/10.7868/S00444537171202143
 Larikov L. N., Ryabov V. R., Fal’chenko V. M. Diffuzionnye processy v tverdoj faze pri svarke [Diffusive processes in a fi rm phase when welding]. Moscow, Mashinostroenie Publ., 1975, 192 p. (in Russ.)
 Roslyakova L. I., Roslyakov I. N. Diffuzionnye i kineticheskie protsessy na poverkhnosti stali pri tsementatsii [Diffusion and kinetic processes on the surface of steel during carburizing]. Uprochnyayuschie tehnologii i pokrytiya, 2014(112), p. 32. (in Russ.)
 Robinson W. M., Bever M. B. Metallurgical Transactions, 1967, 239, p. 1015.
 Petrunin I. E., Markova I. Yu., Ekatova A. S. Metallovedenie pajki [Metallurgy Soldering]. Moscow, Metallurgiya Publ., 1976, 264 p. (in Russ.)
 Ivanov S. G., Gur’ev M. A., Gur’ev A. M. Calculation of diffusion coeffi cient of simultaneous complex steel borating process. Aktual’nye problemy v mashinostroenii, 2015(2), pp. 416-420. (in Russ.)
 Gurov K. P., Kartashkin B. A., Ugaste Yu. E. Vzaimnaya diffuziya v mnogofaznyh metallicheskih sistemah [Mutual diffusion in multiphase metal systems]. Moscow, Nauka Publ., 1981, 350 p. (in Russ.)
 van Loo F. J. J., Rieck G. Diffusion in the Ti–Al system. Interdiffusion between solid Al and Fe or Ti–Al alloys. Acta Metallyrg., 1973, v. 21, pp. 61–71. https://doi.org/10.1016/0001-6160(73)90220-4
 Borisov V. I., Borisov T. V. Effect of interfacial reaction rate on diffusion layer growth kinetics. Fizika metallov i metallovedeniya, 1976, v. 42, p. 496. (in Russ.)
 Ganseen M., Rieck G. Effect of interfacial reaction rate on diffusion layer growth kinetics. Trans. Met. Soc. of AJME. 1967, v. 239, p. 1372.
 Bastin G.D., Rieck G. Diffusion in the Ti–Ni system. Occurrence and growth of the various intermetallic compounds. Met. Trans. Soc. 1974, v. 5, p. 1817. https://doi.org/10.1007/bf02644146
 Clark E. J. Vacuum diffusion joining of titanium. Welding Journel., 1959, v. 38, p. 251.
 Lashko N. F., Lashko S. V. Pajka metallov [Soldering of metals]. Moscow, Mashinostroenie Publ., 1988, 376 p. (in Russ.)
 Neverov V. I. Issledovanie kinetiki diffuzionnogo rosta faz v binarnyh sistemah so slozhnoj diagrammoj sostoyaniya, primenyaemyh v novoj tehnike [The study of the kinetics of diffusion phase growth in binary systems with a complex state diagram used in the new technique]. Cand. phys. and math. sci. diss. Sverdlovsk, 1981, 192 p. (in Russ.)
 Bugakov V. Z. Diffuziya v metallah i splavah [Diffusion in metals and alloys]. Leningrad, Gostehizdat Publ., 1949, 206 p. (in Russ.)
 Gryzunov V. I., Sokolovskaya E. M., Ajtbaev B. K. O kontsentratsionnoy i temperaturnoy zavisimosti koeffi tsientov diffuzii [On the concentration and temperature dependence of diffusion coeffi cients]. Izv. AN KazSSR. Seriya himicheskaya, 1983(6), pp. 19–26. (in Russ.)
 Ajtbaev B. K., Gryzunov V. I., Sokolovskaya E. M. Issledovanie vzaimnoy diffuzii v sisteme titan – tsirkoniy [Study of mutual diffusion in titanium-zirconium system]. Vestnik Moskovskogo universiteta. Ser. 2, Himiya [Moscow University Chemistry Bulletin], 1993, v. 34(2), pp. 179–180. (in Russ.)
 Gurevich L. M., Trykov Yu. P., Arisova V. N., Kiselev O. S., Kondrat’ev A. Yu., Metelkin V. V. Struktura i svoystva sloistykh titano-alyuminievykh kompozitov, uprochnennykh chastitsami intermetallidov [Structure and properties of layered titanium-aluminum composites reinforced with intermetallide particles]. Izvestiya VolGTU, Seriya «Problemy materialovedeniya svarki i prochnosti v mashinostroenii», 2009(59), pp. 5–10. (in Russ.)
 Shmorgun V. G., Trykov Yu. P., Slautin O. V., Bogdanov A. I, Bityuckih A. E. Struktura i svoystva sloistykh titano-alyuminievykh kompozitov, uprochnennykh chastitsami intermetallidov {Effect of thermal and force effects on diffusion layer growth kinetics in nickel-aluminum composite]. Izvestiya VolGTU, Seriya «Problemy materialovedeniya svarki i prochnosti v mashinostroenii», 2009(59), pp. 35–39. (in Russ.)
 Chernyshev A. P., Ovchinnikov V. V. Opredelenie inkubatsionnogo perioda strukturnykh i fazovykh prevrashcheniy v stali [Determination of incubation period of structural and phase transformations in steel] Metallovedenie i termicheskaya obrabotka metallov. Izvestiya VUZov. Chernaya metallurgiya,1998(2), pp. 48–49. (in Russ.)
 Treheus G., Guiraldeng P. Infi uence des paliers de reaction isotherme sur la croissance par diffusione des composes d’un diagramme d’equilibre benaire. Compt. Rend. Acad. Sci. B, 1972, v. 275, p. 105.
 Shmogun V. G., Trykov Yu. P., Slautin O. V., Metelkin V. V., Bogdanov A. I. Kinetika diffuzionnykh protsessov v nikel’-alyuminievoy kompozitsii [Kinetics of diffusion processes in nickel-aluminum composi-tion]. Izvestiya vuzov. Poroshkovaya metallurgiya i funkcional’nye pokrytiya, 2008(4), pp. 24–28. (in Russ.)
 Mazanko V. F., Prokopenko G. I., Shterenberg A. M., Gercriken D. S., Mironova T. V. Osobennosti fazoobrazovaniya v zheleze i stali v usloviyakh ul’trazvukovoy udarnoy obrabotki [Features of phase formation in iron and steel under conditions of ultrasonic impact treatment]. Fizika i himiya obrabotki materialov, 2006(2), pp. 73–82. (in Russ.)
 Kulemin A. V., Mickevich A. M. Diffuziya v sisteme Cu–Zn pri deystvii znakoperemennykh napryazheniy [Diffusion in Cu - Zn system under alternating voltages]. Metallofi zika novejshie tehnologii, 2007(3), pp. 305–315. (in Russ.)
 Krutilin A. N., Kuharchuk M. N., Sycheva O. A. Review of the methods of intensifi cation of diffused processes of oxides deoxidation // Lit’e i metallurgiya, 2011(60), pp. 45–49. (in Russ.)
 Glensk A., Grabowski B., Hickel T., Neugebauer J. Breakdown of the arrhenius law in describing vacancy formation energies: the importance of local anharmonicity revealed by ab initio thermodynamics. Physical Review X, 2014, v. 4(1), p. 011018. https://doi.org/10.1103/physrevx.4.011018

Rad najprije utvrđuje da iz pojma prvobitnog znanja (liangzhi 良知) Wanga Yangminga王陽明 (1472. – 1529.) ne slijedi subjektivni idealizam te da je vezan za transcendentalnu subjektivnost u smislu fenomenologije. Zatim, raspravlja se o pitanju ima li Wang pojam prvobitne sposobnosti (liangneng 良能). Argumentira se da se može naći u dvije glavne Wangove teme – »znanje i radnja jedno su« (zhixing heyi 知行合一) te »razmatrati Nebo i Zemlju i mnoštvo stvari kao jedno (rizomatično) tijelo« (以天地萬物為一體) ili ih smatrati »izvorno jednim s mojim (rizomatičnim) tijelom« (本吾一體). Pokazuje se da su prvobitno znanje i sposobnost dva aspekta isto fenomena. Istinito je na razini virtualnog »rizomatskog tijela« (ti 體), a ne na razini stvari razmatranih kao potpuno oblikovane i aktualizirane (xing 形), kako se pojavljuju u empirijskom umu, zamagljeni žudnjama (yu 欲) koje postaju fiksirane na razini aktualnog. Te se žudnje mogu razriješiti putem »proširenja (prvobitnog) znanja« zhi (liang)zhi 致(良)知. Usporedni pojam »proširenja (prvobitne) sposobnosti« (zhi liangneng 致良能), koji Wang Yangming ne koristi, može se unijeti u sustav.

All-solid-state lithium-ion batteries (ASSLIBs) with oxide-based solid electrolytes are a promising candidate for next generation of rechargeable batteries, due to their reliability and high-energy density. The formation of well-defined electrode/solid electrolyte interfaces with an excellent ionic conductivity by co-sintering is one of the key challenges to develop oxide-based ASSLIBs.1 Electrode materials and solid electrolytes often react with each other to form a resistive substance at their interface during co-sintering.2-4 Thus, optimization of the co-sintering conditions is important to control the interfacial structure which governs the ionic conductivity. However, the effect of the interfacial structure on the ionic conductivity remains unclear. In this study, we co-sintered the composites of LiCoPO4 (LCP) electrode material and Li1.3Al0.3Ti1.7(PO4)3 (LATP) oxide-based solid electrolyte and investigated the interfacial structure by using X-ray diffraction (XRD), X-ray absorption fine structure (XAFS) and scanning transmission electron microscopy combined with electron energy loss spectroscopy and an energy-dispersive X-ray spectroscopy (STEM-EELS/EDX). Figure 1(a) shows the XRD patterns of the LCP/LATP composites before and after sintering at 800°C. The diffraction patterns are almost identical to each other and all the diffraction peaks are attributed to the LCP and LATP with an exception of AlPO4 impurity. However, the Co K-edge XANES is slightly changed after sintering as shown in Figure 1(b). These results suggest that a small amount of LCP and LATP react with each other. Figure 1(c) shows a typical STEM image of the LCP/LATP composites after sintering at 800°C. According to EDX analysis, light and dark gray domains correspond to LCP and LATP, respectively. Apart from LCP and LATP, there are two types of LCP/LATP interfaces: interface A and B. Line profile STEM-EELS/EDX analysis revealed that LCP and LATP directly bound to each other at the interface A. On the other hand, a thermally reacted thin layer, possibly cobalt oxide (CoO) and/or cobalt phosphide (Co2P), is formed at interface B. The effect of such thermally reacted interlayer on the ionic conductivity will be discussed in detail. References: R. Chen, Q. Li, X. Yu, L. Chen and H. Li, Chemical Reviews, 2020, 120, 6820-6877. M. Gellert, E. Dashjav, D. Grüner, Q. Ma and F. Tietz, Ionics, 2017, 24, 1001-1006. C.-Y. Yu, J. Choi, V. Anandan and J.-H. Kim, The Journal of Physical Chemistry C, 2020, 124, 14963-14971. L. Miara, A. Windmuller, C. L. Tsai, W. D. Richards, Q. Ma, S. Uhlenbruck, O. Guillon and G. Ceder, ACS Applied Materials and Interfaces, 2016, 8, 26842-26850. Figure 1

Among the potential cathode material classes for Na-ion batteries, O3-type layered NaxTMO2s (TM => transition metal ion) are of importance due to their high starting Na-content (of ~1 per formula unit; x). However, the O3-type NaxTMO2s suffer from multiple structural phase transformations during electrochemical charge/discharge cycles, TM-dissolution into electrolyte [1-2] and, more importantly, inherent sensitivity to moisture [3]. The moisture sensitivity of these ‘layered’ NaxTMO2s necessitates the usage of toxic/hazardous non-aqueous solvents like N-Methyl-2-pyrrolidone (NMP) during electrode preparation. Against this backdrop, a carefully designed composition has been developed in this work, which addresses the aforementioned problems, in particular, the air/water-instability. Partial/complete substitution of Ti-ion for Mn-ion in Na(Li0.05Mn0.5-xTixNi0.30Cu0.10Mg0.05)O2 eliminated the presence of Mn3+ (which dissolves in electrolyte) at the particle surface, supressed increment in impedance and voltage hysteresis during electrochemical cycling and, thus, significantly improved cyclic stability of Ti-substituted O3-type layered NaxTMO2s. The Mn-containing Na-TM-oxides were found to be extremely unstable in terms of phase/structure retention upon exposure to air and water; progressively evolving O’3 and P3 phases due to spontaneous Na-loss and thereby forming undesired NaOH and Na2CO3 phases on the particle surface (see Fig. 1a), causing increase in electrochemical impedance. By contrast, no phase/structural change occurred upon partial/complete Ti-substitution (for Mn-ion), even after 40 days of air-exposure and 12 h of soaking, as well as stirring, in water (viz., very stringent hydration condition) (see Fig. 1b). Such excellent stability against hydration, which was partly due to reduced Na-ion ‘inter-slab spacing’ in the presence of Ti-ion, was not reported earlier for O3-type Na-TM-oxides. The excellent stability of the optimized O3-type NaTMO2 enables the usage of environment/health-friendly and economical ‘aqueous-binder’ (viz., Na-alginate) and water (as solvent) for electrode preparation. Overall, the ‘aqueous-processed’ cathode exhibits first cycle capacity of ~125 mAh/g (between 2-4 V; vs. Na/Na+), with smooth electrochemical cycling profiles (see Fig. 2a) and excellent long-term cyclic stability, with a capacity retention of ~56% after 750 cycles at C/5 (see Fig. 2b). Overall, the present work, as published in ref. [4], has established important correlations between the composition, structure (viz., reduction in ‘inter-slab spacing’), stability against hydration (viz., in air and water), feasibility for health/environmental-friendly ‘aqueous processing’ of electrodes, electrochemical impedance, stability of average voltages and cyclic stability of O3-type Na-TM-oxide based cathode materials for Na-ion batteries. Keywords: Na-ion battery; layered transition metal oxide cathode; air/water-stability; aqueous processing; electrochemical behaviour Reference s : [1] S. Komaba, N. Yabuuchi, T. Nakayama, A.Ogata and T. Ishikawa, Inorg.chem, 51, 6211–6220 (2012). [2] P. F. Wang, Y. You, Y. X. Yin and Y. G. Guo, J. Mater. Chem. A, 4, 17660–17664 (2016). [3] H. R. Yao, P. F. Wang, Y. Gong, J. Zhang, X. Yu, L. Gu, C. Ouyang, Y. X. Yin, E. Hu, X. Q. Yang, E. Stavitski, Y. G. Guo and L. J. Wan, J. Am. Chem. Soc., 139, 8440–8443 (2017). [4] B. S. Kumar, A. Pradeep, A. Dutta, A. Mukhopadhyay., J. Mater. Chem. A, 8, 18064-18078 (2020). Figure 1

Second language teaching (SLT) focuses on the cultural backgrounds of different learners. This not only facilitates the construction of knowledge using the learner’s identity, but also helps learners acquire skills for cross-cultural communication, both of which are needed for learners to develop sustainably. Sino-Korean vocabulary is an important element in the representation of Korean culture and in teaching the Chinese language to Korean speakers. In addition, it is a means of promoting the Teaching Chinese as a Second language (TCSL) to achieve sustainable development for Korean learners. Much of the research on Sino-Korean vocabulary has focused on the similarities between Chinese and Korean cultures that facilitate Korean learners’ understanding and use of Sino-Korean vocabulary, but little attention has been paid to the role played by cultural Sino-Korean vocabulary that represent the distinctive Korean culture. We collected a news corpus on six major themes from the NAVER website in Korea from between 2010 and 2020. The keywords were extracted using the TF–IDF algorithm and then transcribed and culled to form a distinctive cultural Sino-Korean vocabulary corpus. We examined the Korean Version of Experience Chinese: Living in China (Ti yan Han yu Sheng huo pian) and suggested that a collection of Sino-Korean vocabulary that are culturally distinctive to the learner’s home country can provide a more pedagogically meaningful addition to the selection of words for TCSL textbooks. These words, based on similarities, further enable Korean learners to acquire a sense of familiarity with, and belonging to, their identity, and thus acquire the Chinese language, and also facilitate expression in intercultural communication. By extracting the distinctive Korean cultural Sino-Korean vocabulary and discovering their value in terms of TCSL educational material, we can promote the sustainable development of Korean learners.

Lithium metal is considered as one of the most promising anode candidates for high-energy batteries [1-3]. However, safety concerns induced by the formation of Li dendrites largely hinder the practical application of lithium-metal batteries [4]. It is anticipated that the use of non-flammable inorganic solid-state electrolytes can resolve these safety issues [5], but solid ceramic electrolytes generally suffer from poor physical contact with the electrode and poor electro-/chemical stability at the electrolyte|electrode interface [6]. Herein, we report on a thin and flexible hybrid electrolyte composed of NASICON-type Li1.3Al0.3Ti1.7(PO4)3 (LATP), a polymer binder, and a small amount of an ionic liquid-based electrolyte. To reinforce the interfacial stability between LATP and Li, we coat an ultrathin polysiloxane-based single-ion conducting polymer (PSiO) on the Li metal surface via a simple dip-coating method. The implementation of PSiO-coated Li (PSiO@Li) in symmetric PSiO@Li||PSiO@Li cells enables a substantial extension of the cycle life, yielding >2,000 h of stable lithium stripping-plating. The full-cells comprising PSiO@Li as the negative electrode, LiNi0.88Co0.09Mn0.03O2 (NCM88) as the positive electrode active material, and the aforementioned hybrid electrolyte exhibit substantially enhanced rate capability at high dis-/charge rates above 0.5C and greatly prolonged cycle life at 1C. The superior performance achieved herein is mainly attributed to: (1) the prevented direct contact between LATP and Li, thus avoiding the reduction of LATP and the formation of mixed ion-electron conducting interphases; (2) the regulated Li+ flux at the electrode|electrolyte interface, ensuring homogeneous Li+ stripping-plating; and (3) the promoted intimate contact between PSiO and Li via the formation of Si−O−Li bonds. References [1] T. Li, X.-Q. Zhang, P. Shi, Q. Zhang, Joule, 3 (2019) 2647-2661. [2] B. Horstmann, J. Shi, R. Amine, M. Werres, X. He, H. Jia, F. Hausen, I. Cekic-Laskovic, S. Wiemers-Meyer, J. Lopez, D. Galvez-Aranda, F. Baakes, D. Bresser, C.-C. Su, Y. Xu, W. Xu, P. Jakes, R.-A. Eichel, E. Figgemeier, U. Krewer, J.M. Seminario, P.B. Balbuena, C. Wang, S. Passerini, Y. Shao-Horn, M. Winter, K. Amine, R. Kostecki, A. Latz, Energy Environ. Sci., 14 (2021) 5289-5314. [3] S. Wang, P. Xiong, J. Zhang, G. Wang, Energy Storage Materials, 29 (2020) 310-331. [4] Z. Yu, Y. Cui, Z. Bao, Cell Rep. Phy. Sci., 1 (2020) 100119. [5] S. Xin, Y. You, S. Wang, H.-C. Gao, Y.-X. Yin, Y.-G. Guo, ACS Energy Lett., 2 (2017) 1385-1394. [6] A. Banerjee, X. Wang, C. Fang, E.A. Wu, Y.S. Meng, Chem. Rev., 120 (2020) 6878-6933.

Abstract LCB84 is a human Trop-2-targeting antibody drug conjugate (ADC) composed of monomethyl auristatin E (MMAE) as payload and the Hu2G10 (by Mediterranea Theranostic) humanized IgG1 antibody that selectively targets the ADAM10-activated Trop-2 protein selectively expressed in transformed cancer cells (1). LCB84 was prepared using ConjuAll࣪, a proprietary site-directed conjugation technology of LegoChem Biosciences, which incorporates a conjugation ‘handle’ joined by enzymatic prenylation to a specifically engineered recognition sequence (CaaX) on antibody light chains. This conjugation handle facilitates simple versatile chemical conjugation to the linker-payload. A proprietary plasma-stable cleavable linker that is recognized and cleaved by a cancer-associated lysosomal enzyme, β-glucuronidase, was used to enable efficient and traceless payload release in a cancer-specific manner. LCB84 has been evaluated for anti-tumor activity and showed superior anticancer efficacy in triple-negative breast cancer (TNBC), pancreatic ductal adenocarcinoma (PDAC), gastric cancer and non-small cell lung cancer (NSCLC) cell line-derived xenograft (CDX) models compared to the ADC competitors Trodelvy and DS-1062. The LCB84 treatments were well tolerated, with no changes in body weight compared to control animals, for all dosing groups. LCB84 has robust cross-reactivity against primate Trop-2, which allows rigorous toxicity studies in monkeys. Remarkably, preliminary toxicity studies using cynomolgus monkeys showed that LCB84 is well tolerated, with calculated therapeutic index (TI, MTD/MED) of ~30 for single dosing and ~40 for repeat dosing. In conclusion, LCB84 is highly effective against Trop-2-positive CDX models in mice at doses that are well tolerated in mice and in primate models. Use of this proprietary plasma-stable cancer-selective linker technology and the Hu2G10 anti-Trop-2 monoclonal antibody that targets cancer-activated Trop-2 has led to a greatly improved next generation ADC for the treatment of various Trop-2-positive solid cancers including TNBC, PDAC, NSCLC and gastric cancer. Citation Format: Hyejung Kim, Emanuela Guerra, Eunji Baek, Yeojin Jeong, Hyogeun You, Byeongjun Yu, Taeik Jang, Alberti Saverio, Chul-Woong Chung, Changsik Park. LCB84, a TROP2-targeted ADC, for treatment of solid tumors that express TROP-2 using the hu2G10 tumor-selective anti-TROP2 monoclonal antibody, a proprietary site-directed conjugation technology and plasma-stable tumor-selective linker chemistry [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 328.

The energy-water nexus poses an integrated research challenge with crucial global implications. The nexus highlights the need to adopt a proactive approach by focusing on the conservation and management of both resources. As global freshwater supply continues to deplete, a larger number of people in the world will need to rely on recycled water. One of the ways to address this concern is by focusing efforts on the development and deployment of energy efficient water remediation technologies. Ammonia is one of the most common contaminants found in domestic and industrial wastewater. Concurrently, it is also one of the most liberally produced chemicals because of its widespread use in the agricultural and textile industries. In 2020, approximately 144 million metric tons of ammonia were produced globally (1). Despite that, biological nitrification remains the most widespread method for treating ammonia wastewater (2). Aside from being cumbersome and slow, it also fails to recover ammonia, which is otherwise a valuable product. In pursuit of sustainability, product conservation directly translates to energy conservation and there remains a need for a water purification and ammonia recovery technology that is energy, water, and resource efficient. Capacitive deionization (CDI) is a separation technology that removes ions from water by applying a small voltage below the dissociation potential of water (1.23 V). The ions are temporarily stored in the electrodes and later released to a separate concentrated stream upon voltage removal or reversal. Flowing electrode CDI systems (FE-CDI) have proven advantageous because of their ability to prevent cross contamination, and to run in uninterrupted cycles ad infinitum . The performance of FE-CDI systems relies on the selection of suitable electrode materials with desired properties of high electrical conductivity, high surface area, colloidal stability, and surface sensitivity (3). MXenes are an emerging class of two-dimensional (2D) materials that are highly conductive, hydrophilic, tunable, and possess attractive charge storage and ion transport properties (4,5). In this work, we developed a flowing electrode capacitive deionization (FE-CDI) system using Ti3C2T x MXene suspension electrodes for the removal and recovery of ammonia from synthetic wastewater. A custom-built FE-CDI unit using titanium current collectors with an effective transfer area of 10 cm2 was used to test system efficiency. The electrode performance was evaluated by operating the CDI system with a feed solution of 500 mg/L NH4Cl running in batch mode at a constant voltage of 1.2 and -1.2 V in charging and discharging stages respectively. Despite low loading (1 mg/ml), Ti3C2T x flow electrodes showed a markedly improved performance by achieving 60% ion removal efficiency (Fig. 1a) in a short saturation time of 115 minutes, and an unprecedented ion adsorption capacity of 460 mg/g (Fig. 1b). This is ~ 7× higher than the currently reported value using Ti3C2 in a conventional CDI system targeted at sodium chloride (NaCl) desalination (6). Post-mortem characterization of the suspension electrodes by X-ray diffraction revealed that Ti3C2T x MXene sequestered high amounts of pollutants due to its ability to intercalate ions between its 2D layers. The electrodes possessed favorable electrochemical properties with a high specific capacitance of 148 F/g. The system proved to be a green technology by exhibiting satisfactory charge efficiency of 58-70% while operating at a relatively low energy consumption of 0.45 kWh/kg (Fig. 1c), which is about an order of magnitude lower than the 4.6 kWh/kg used by commercial wastewater treatment plants (7). The results demonstrate that the Ti3C2T x MXene electrodes have the potential to improve the FE-CDI process for energy-efficient removal and recovery of ammonia. IEA, Ammonia Technology Roadmap, International Energy Agency, Paris, (2021). F. Jaramillo, M. Orchard, C. Muñoz, M. Zamorano, and C. Antileo, J. Environ. Manage., 218, 154–164 (2018). Y. Oren, Desalination, 228, 10–29 (2008). Y. Gogotsi and B. Anasori, ACS Nano, 13, 8491–8494 (2019). P. Singh et al., J. Power Sources, 506 (2021). J. Ma, Y. Cheng, L. Wang, X. Dai, and F. Yu, Chem. Eng. J., 384 (2020). M. Ekman, B. Björlenius, and M. Andersson, Water Res., 40, 1668–1676 (2006). Figure 1

We presented a numerical investigation of a metamaterial narrowband perfect absorber conducted via a finite element method based on commercially available COMSOL software. The periodic array of silicon meta-atoms (MAs) are placed on 80 nm thick gold layer. The broadband light at normal incidence is blocked by the gold layer and silicon MAs are used to excite the surface plasmon by scattering light through it. Maximum absorption of 95.7 % is obtained at the resonance wavelength of 1137.5 nm due to the perfect impedance matching of the electric and magnetic dipoles. The absorption is insensitive to the wide-angle of incidence ranging from 0 to 80 degrees. We believe that the proposed metamaterial device can be utilized in solar photovoltaic and biochemical sensing applications. Full Text: PDF ReferencesY. Cheng, X.S. Mao, C. Wu, L. Wu, R.Z. Gong, "Infrared non-planar plasmonic perfect absorber for enhanced sensitive refractive index sensing", Optical Materials, 53, 195-200 (2016). CrossRef S. S. Mirshafieyan, D.A. Gregory, "Electrically tunable perfect light absorbers as color filters and modulators", Scientific Reports,8, 2635 (2018). CrossRef D.M. Nguyen, D. Lee, J. Rho, "Control of light absorbance using plasmonic grating based perfect absorber at visible and near-infrared wavelengths", Scientific Reports, 7, 2611 (2017). CrossRef Y. Sun, Y. Ling, T. Liu, L. Huang, "Electro-optical switch based on continuous metasurface embedded in Si substrate", AIP Advances, 5, 117221 (2015). CrossRef H. Chu, Q. Li, B. Liu, J. Luo, S. Sun, Z. H. Hang, L. Zhou, Y. Lai, "A hybrid invisibility cloak based on integration of transparent metasurfaces and zero-index materials", Light: Science & Applications, 7, 50 (2018). CrossRef S. K. Patel, S. Charola, J. Parmar, M. Ladumor, "Broadband metasurface solar absorber in the visible and near-infrared region", Materials Research Express, 6, 086213 (2019). CrossRef Q. Qian, S. Ti, C. Wang, "All-dielectric ultra-thin metasurface angular filter", Optics Letters, 44, 3984 (2019). CrossRef P. Yu et al., "Broadband Metamaterial Absorbers", Advanced Optical Materials, 7, 1800995 (2019). CrossRef Y. J. Kim et al., "Flexible ultrathin metamaterial absorber for wide frequency band, based on conductive fibers", Science and Technology of advanced materials, 19, 711-717 (2018). CrossRef N.L. Kazanskiy, S.N. Khonina, M.A. Butt, "Plasmonic sensors based on Metal-insulator-metal waveguides for refractive index sensing applications: A brief review", Physica E, 117, 113798 (2020). CrossRef H. E. Nejad, A. Mir, A. Farmani, "Supersensitive and Tunable Nano-Biosensor for Cancer Detection", IEEE Sensors Journal, 19, 4874-4881 (2019). CrossRef

Работа посвящена обобщению результатов исследования анодирования алюминида титана (γ-TiAl) во фторсодержащих электролитах. Установлены оптимальные условия анодирования, приводящие к формированию самоорганизованных нанопористых анодных оксидных пленок (АОП) на поверхности образцов, сплава Ti-40 wt. % Al. Показано, что при оптимальных условиях образуются рентгеноаморфные оксидные пленки гетерогенного состава (Al2O3:TiO2 @ 1:1) с размерами пор в диапазоне от 40 до 80 nm. Полученные результаты свидетельствуют о перспективности применения анодного наноструктурирования порошков Ti-40 wt. % Al для получения фотокаталитически активных материалов с расширенным до видимого света спектральным диапазоном поглощения.
 
 
 ЛИТЕРАТУРА
 
 Wang Y., Ma X., Li H., Yin S., Sato T. Advanced Catalytic materials - Photocatalysis and Other Current Trends, 2016, vol. 12, pp. 337–357. https://doi.org/10.5772/61864
 Hashimoto K., Irie H., Fujishima A. Japanese Journal of Applied Physics, 2005, vol. 44, no. 12, pp. 8269–8285. https://doi.org/10.1143/jjap.44.8269
 Uddin Md.T., Engg M. Sc. Dr. Rer. Nat. Technical University of Darmstadt, 2014, 222 p. URL: https://d-nb.info/1061050335/04 (accessed 28.11.2018)
 Batzill M. Energy Environ. Sci., 2011, vol. 4, pp. 3275–3286. https://doi.org/10.1039/c1ee01577j
 Marschall R. Funct. Mater., 2014. vol. 24. pp. 2421–2440. https://doi.org/10.1002/adfm.201303214
 Ghicov A., Schmuki P. Commun., 2009, pp. 2791–2808. https://doi.org/10.1039/b822726h
 Li F., Zhao Y., Hao Y., Wang X., Liu R., Zhao D., Chen D. Journal of Hazardous Materials, 2012, vol. 239–240. pp. 118–127. https://doi.org/10.1016/j.jhazmat.2012.08.016
 Morris S. M., Horton J. A., Jaroniec M. Mesopor. Mater., 2010, vol. 128, pp. 180–186. https://doi.org/10.1016/j.micromeso.2009.08.018
 Ahmed M. A., Abdel-Messih M. F. Journal of Alloys and Compounds, 2011, vol. 509, pp. 2154–2159. https://doi.org/10.1016/j.jallcom.2010.10.172
 Pakmehr M., Nourmohammadi A., Ghashang M., Saffar-Teluri A. Journal of Particle Science and Technology, 2015, pp. 31–38. https://doi.org/22104/JPST.2015.76
 Pei J., Ma W., Li R., Li Y., Du H. Journal of Chemistry, 2015, pp. 1–7. https://doi.org/10.1155/2015/806568
 Il'in, A. A., Kolachev, B. A., Pol'kin, I. S. Titanovye splavy. sostav, struktura, svoistva [Titanium alloys. Composition, structure, properties]. Moscow, VILS-MATI Publ., 2009, 520 p. (in Russ.)
 Tsuchiya, H., Berger, S., Macak, J.M., Ghicov, A., Schmuki, P. Comm., 2007, vol. 9, pp. 2397–2402. https://doi.org/10.1016/j.elecom.2007.07.013
 Berger, S., Tsuchiya, H., Schmuki, P. Mater., 2008, vol. 20, pp. 3245–3247. https://doi.org/10.1021/cm8004024
 Stepanova K. V., Yakovleva N. M., Kokatev A. N., Pettersson Kh. zap. PetrGU. Seriya Estestvennye i tekhnicheskie nauki, 2015, vol. 147, no. 2, pp. 81–86. (in Russ.)
 Stepanova К. V., Yakovleva N. M., Kokatev А. N., Pettersson H. Journal of Surface Investigation. X-ray, Synchrotron and Neutron Techniques, 2016, vol. 10, no. 5, pp. 933– https://doi.org/10.1134/S102745101605013X
 Stepanova K. V. Diss. kand. tekh. nauk. Petrozavodsk, 2016, 162 p. (in Russ.)
 Yakovleva N. M., Kokatev A. N., Chupakhina E. A., Stepanova K. V., Yakovlev A. N., Vasil'ev S. G., Shul'ga A. M. Condensed Matter and Interphases, 2016, vol. 18, no. 1, pp. 6− URL: http://www.kcmf.vsu.ru/resources/t_18_1_2016_001.pdf (in Russ.)
 Kokatev A. N. Diss. kand. tekh. nauk. Petrozavodsk, 2013, 170 p.
 Savchenko O. I., Yakovleva N. M., Yakovlev A. N., Kokatev A. N., Pettersson Kh. Condensed Matter and Interphases, 2012, vol. 14, no. 2, pp. 243–249. URL: http://www.kcmf.vsu.ru/resources/t_14_2_2012_018.pdf (in Russ.)
 Canulescu S., Rechendorff K., Borca C.N., Jones N.C., Bordo K., Schou J., Pleth Nielsen L., Hoffmann S. V., Ambat R. Applied Physics Letters, 2014, vol. 104, pp. 121910(1–4). https://doi.org/10.1063/1.4866901
 Chen C., Liu J., Liu P., Yu B. Advances in Chemical Engineering and Science, 2011, vol. 1, pp. 9– https://doi.org/10.4236/aces.2011.11002
 Rashed M. N., El-Amin A. A. International Journal of Physical Sciences, 2007, vol. 2 (3), pp. 073–081. URL: http://www.academicjournals.org/IJPS (accessed 28.11.2018)
 Ivanov V. M., Tsepkov M. G., Figurovskaya V. N. Vestnik Moskovskogo universiteta. Seriya 2: Khimiya [Moscow University Chemistry Bulletin], 2010, vol. 65, 6, pp. 370-373. https://link.springer.com/article/10.3103%2FS0027131410060076
 Scuderi V., Impellizzeri G., Romano L., Scuderi M., Nicotra G., Bergum K., Irrera A., Svensson B.G., Privitera V. Nanoscale Research Letters, 2014, vol. 9, pp. 458–464. https://doi.org/10.1186/1556-276x-9-458 
 AbdElmoula M. Dr. Philosophy. Boston, 2011, 275 р.
 Lee K., Mazare A., Schmuki P. Rev., 2014, vol. 114, pp. 9385–9454. https://doi.org/10.1021/cr500061m
 Leyens C., Peters M. Titanium and Titanium Alloys. Fundamentals and Applications. Weinheim: WILEY-VCH Verlag GmbH & Co. KGaA, 2003, 532 p.
 

We demonstrated the possibility of using the mathematical form of Darken's theory, applied to the description of the Kirkendall effect in binary systems, to the description of reactive interdiffusion in non-stoichiometric polycrystalline film oxide systems with limited solubility. The aim of the study was the simulation of reactive interdiffusion under vacuum annealing of a thin film system consisting of two non-stoichiometric polycrystalline titanium and cobalt oxides. The nonstoichiometric nature of the system assumes the presence of mobile components, free interstitial cobalt and titanium cations in it. Phase formation occurs as a result of reactive interdiffusion and trapping of mobile components of the systemon inter-grain traps. The proposed mechanism describes the formation of complex oxide phases distributed over the depth of the system.A complex empirical research technique was used, involving Rutherford backscattering spectrometry, X-ray phase analysis and modelling methods. The values of the characteristic parameters of the process were determined by numerical analysis of the experimentally obtained distributions of the concentrations of the components within the developed model. During vacuum annealing of a thin film two-layer system of non-stoichiometric TiO2–x–Co1–уO oxides in temperature range T = 773 – 1073 К, the values of the individual diffusion coefficients of cobalt DCo = 5.1·10–8·exp(–1.0 eV/(kT) cm2/s and titaniumDTi = 1.38·10–13·exp(–0.31 eV/(kT) cm2/s were determined.It was shown that for T = 1073 K, the phase formation of CoTiO3 with a rhombohedral structure occurs. The extension of the phase formation region of complex cobalt and titanium oxides increases with an increase in the vacuum annealing temperature and at 1073 K it is comparable with the total thickness of the film system.The model allows predicting the distribution of the concentrations of the components over the depth of multilayer nonstoichiometric systems in which reactive interdiffusion is possible.
 
 
 
 References1. Chebotin V. N. Fizicheskaya khimiya tverdogo tela[Physical chemistry of a solid state]. Moscow: KhimiyaPubl.; 1982. 320 p. (in Russ.)2. Tretyakov Yu. D. Tverdofaznye reaktsii [Solidphase reactions]. Moscow: Khimiya Publ.; 1978. 360 p.(in Russ.)3. Afonin N. N., Logacheva V. A. Interdiffusion andphase formation in the Fe–TiO2 thin-film system.Semiconductors. 2017;51(10): 1300–1305. DOI: https://doi.org/10.1134/S10637826171000254. Afonin N. N., Logacheva V. A. Cobalt modificationof thin rutile films magnetron-sputtered in vacuumtechnical. Technical Physics, 2018;63(4): 605–611. DOI:https://doi.org/10.1134/S10637842180400235. Afonin N. N., Logacheva V. A. Modeling of thereaction interdiffusion in the polycrystalline systemswith limited component solubility. IndustrialLaboratory. Diagnostics of Materials. 2019;85(9): 35–41.DOI: https://doi.org/10.26896/1028-6861-2019-85-9-35-41diffusion (In Russ., abstract in Eng.)6. Afonin N. N., Logacheva V. A. Modeling ofinterdiffusion and phase formation in the thin-filmtwo-layer system of polycrystalline oxides titaniumand cobalt. Kondensirovannye sredy i mezhfaznyegranitsy = Condensed Matter and Interphases.2019;21(3): 358–365. DOI: https://doi.org/10.17308/kcmf.2019.21/1157 (In Russ., abstract in Eng.)7. Darken L. S. Diffusion, mobility and theirinterrelation through free energy in binary metallicsystems. Trans. AMIE.1948;175: 184–190.8. Gurov K. P., Kartashkin B. A., Ugaste Yu. E.Vzaimnaya diffuziya v mnogofaznykh metallicheskikhsistemakh [Interdiffusion in multiphase metallicsystems]. Moscow: Nauka Publ.; 1981. 350 p. (In Russ.)9. Kulkarni N. S., Bruce Warmack R. J., RadhakrishnanB., Hunter J. L., Sohn Y., Coffey K. R., …Belova I. V. Overview of SIMS-based experimentalstudies of tracer diffusion in solids and application toMg self-diffusion. Journal of Phase Equilibria andDiffusion. 2014;35(6): 762–778. DOI: https://doi.org/10.1007/s11669-014-0344-410. Aleksandrov O. V., Kozlovski V. V. Simulationof interaction between nickel and silicon carbideduring the formation of ohmic contacts. Semiconductors.2009;43(7): 885–891. DOI: https://doi.org/10.1134/S106378260907010011. Kofstad P. Nonstoichiometry, diffusion, andelectrical conductivity in binary metal oxides. Wiley-Interscience; 1972. 382 p.12. Bak T., Nowotny J., Rekas M., Sorrell C. C. Defectchemistry and semiconducting properties of titaniumdioxide: II. Defect diagrams. Journal of Physics andChemistry of Solids. 2003;64(7): 1057–1067. DOI:https://doi.org/10.1016/s0022-3697(02)00480-813. Iddir H., Öğüt,S., Zapol P., Browning N. D.Diffusion mechanisms of native point defects in rutileTiO2: Ab initio total-energy calculations. PhysicalReview B. 2007;75(7): DOI: https://doi.org/10.1103/physrevb.75.07320314. Hoshino K., Peterson N. L., Wiley C. L. Diffusionand point defects in TiO2–x. Journal of Physics and Chemistry of Solids. 1985;46(12): 1397-1411. DOI:https://doi.org/10.1016/0022-3697(85)90079-415. Fiebig J., Divinski S., Rösner H., Estrin Y.,Wilde G. Diffusion of Ag and Co in ultrafine-graineda-Ti deformed by equal channel angular pressing.Journal of Applied Physics. 2011;110(8): 083514. DOI:https://doi.org/10.1063/1.365023016. Straumal P. B. Stakhanova S. V., Wilde G.,Divinski S. V. 44Ti self-diffusion in nanocrystalline thinTiO2 films produced by a low temperature wet chemicalprocess. Scripta Materialia. 2018;149: 31–35. DOI:https://doi.org/10.1016/j.scriptamat.2018.01.02217. Patrick R. Cantwell, Ming Tang, Shen J. Dillon,Jian Luo, Gregory S. Rohrer, Martin P. Harmer. Grainboundary complexions. Acta Materialia. 2014;62: 1–48.DOI: https://doi.org/10.1016/j.actamat.2013.07.03718. Dillon S. J., Tang M., Carter W. C., Harmer M. P.Complexion: A new concept for kinetic engineering inmaterials science. Acta Materialia, 2007;55(18):6208–6218. DOI: https://doi.org/10.1016/j.actamat.2007.07.02919. Grain boundary complexion transitions inWO3- and CuO-doped TiO2 bicrystals. Acta Materialia.2013;61(5); 1691–1704. DOI: https://doi.org/10.1016/j.actamat.2012.11.04420. Nie J., Chan J. M., Qin M., Zhou N., Luo J.Liquid-like grain boundary complexion and subeutecticactivated sintering in CuO-doped TiO2. ActaMaterialia. 2017;130: 329–338. DOI: https://doi.org/10.1016/j.actamat.2017.03.037

Background:The lifetime prevalence of lower back pain is between 60% and 70%, with surgical treatments spared for those not responding to other options.Objectives:To investigate the age, gender and socio-economic status differences in back pain procedures in the UK between 2000, 2008 and 2016.Methods:Data was obtained from primary care electronic medical records (CPRD GOLD) linked to English hospital admissions data. Lower back procedures in patients aged 35+ were identified using OPCS-4 codes for Decompression (Dc), Fusion (F), Therapeutic injections (TI) and Denervation (Dn). Standardised incidence rates (IR) of each type of lower back procedures were calculated per 10,000 CPRD registered person years for each age group, gender, region and SES strata in 2000, 2008 and 2016. IR were also calculated for combinations of age and gender. Negative binomial regression calculated incidence rate ratios (IRR) and 95% confidence intervals.Results:The IR of lower back procedures was 21.5 [20.7, 22.3] per 10,000 person years in 2000. This doubled by 2008 (45.5 [44.5, 46.5]) and trebled by 2016 (62.5 [60.8, 64.2]). Number of events and incidence rates of each procedure type are shown in table 1 below. The incidence of Dn has increased 6-fold whilst Dc and F have doubled. Female (IR in 2016 of 73.99 [71.43, 76.61] vs 50.08 [47.90, 52.33] in men, IRR 1.50 [1.41, 1.59]) and age are associated with back procedure rates (figure 1). Large socio-economic differences were observed, with higher procedure rates seen in the most deprived areas. These differences did however narrow over time during the study period (figure 2).Table 1.Event numbers and incidence rates of different types of lower back procedure.FusionDecompressionTherapeutic InjectionDenervationEventsIR (95% CI)EventsIR (95% CI)EventsIR (95% CI)EventsIR (95% CI)20001090.86 (0.71, 1.04)4663.69 (3.36, 4.04)203516.11 (15.42, 16.82)910.72 (0.58, 0.88)20083331.77 (1.58, 1.97)11976.35 (6.00, 6.72)628333.35 (32.53, 34.18)5963.16 (2.91, 3.43)20161591.93 (1.65, 2.26)5256.39 (5.85, 6.96)386547.03 (45.56, 48.54)4875.93 (5.41, 6.48)Figure 1.Age and Gender stratified incidence rate ratios of all back procedures in 2000, 2008 and 2016Figure 2.Deprivation status incidence rate ratios by yearConclusion:The incidence of lower back procedures has more than trebled since 2000. Women are more likely to have lower back procedures than men, with patients aged 65-74 the most likely to have a procedure. Procedures in those aged 75+ have become more common over time, potentially increasing the risk of post-operative complications. Socio-economic differences in the incidence of low back procedures are probably related to the known higher prevalence of back pain in deprived areas. Whether the observed narrowing in socio-economic variation over time is explained by a reduced need or by lowered provision needs further research.Disclosure of Interests:Danielle E Robinson: None declared, Jennifer Lane: None declared, Richard Craig: None declared, Andrew Judge: None declared, James Bailey: None declared, Dahai Yu: None declared, Kelvin Jordan: None declared, George Peat: None declared, Ross Wilkie: None declared, Alan Silman: None declared, Victoria Y Strauss: None declared, Daniel Prieto-Alhambra Grant/research support from: Professor Prieto-Alhambra has received research Grants from AMGEN, UCB Biopharma and Les Laboratoires Servier, Consultant of: DPA’s department has received fees for consultancy services from UCB Biopharma, Speakers bureau: DPA’s department has received fees for speaker and advisory board membership services from Amgen

Abstract X-linked agammaglobulinemia (XLA) is a human immunodeficiency caused by mutations in Bruton’s tyrosine kinase (Btk) and characterized by an arrest in early B-cell development, absence of serum immunoglobulin, and recurrent bacterial infections. Using Btk and Tec double deficient (Btk/Tec−/ −) mice as a model for XLA, we recently showed that onco-retroviral-mediated Btk gene transfer into hematopoietic stem cells (HSC) reconstituted in vivo Btk-dependent B-cell development and function (Yu et al. Blood 104(5):1281–90). In order to increase the safety of this approach, we developed a SIN-lentiviral vector with a B cell specific enhancer/promoter element, Eμ B29. Using SIN-lentiviral vectors expressing GFP, we observed that Eμ B29 consistently promoted 3–5 fold higher GFP expression in human B lineage cells derived from transduced HSC in vitro and in vivo (ASGT 2002 abstract #1302). We also evaluated this vector, CSOM-Eμ B29-GFP-WPRE, in lentiviral transgenic mice where it exhibited the highest GFP expression in peripheral B cells compared with all other hematopoietic lineages. Specifically, in more than 8 independent founder strains the MFI for GFP expression in B cells was > 3 fold higher than that in T cells (p=0.0002). Based upon these findings we developed Eμ B29-huBtk SIN-lentiviral vectors with or without the insulator element derived from the chicken β-globulin insulator (HS4). Using both vectors to transduce Btk −/ − DT40 B cells, followed by cloning by limiting dilution, we demonstrate Btk protein expression by intracellular staining and western blotting and full rescue of Btk-dependent, B cell receptor (BCR)-mediated Ca2+ signaling in all clones evaluated including those exhibiting a single viral integration. Next we tested the capacity of these vectors to reconstitute Btk-dependent B-cell development and function in a cohort of Btk/Tec−/ − mice. Marrow from 5-FU treated Btk/Tec −/ − mice was harvested, cultured on fibronectin coated plates with growth factors (mIL-3,mIL-6, mSCF, mTPO and mFLT3ligand) and concentrated lentivirus (2.3x107pg/106 cells measured by p24 level). After 48h of in vitro culture, cells were transplanted into lethally irradiated animals and transplanted animals were serially evaluated for presence of B cells in the peripheral blood. B-cell numbers progressively increased with a significant difference as early as within 6 weeks in mice receiving transduced (16–18% B220+ cells) vs. control marrow (8–9%; mock transduced). Further, mature B cells (B220+IgMlowIgDhi) represented 14–20% of total B cells in treated compared to <5% in control mice. Finally, mice receiving transduced cells exhibited a rescue of total serum IgM and IgG3 levels and responses to TI-II dependent immunization. Results of two additional animal cohorts will be presented. In summary, our data demonstrate that Eμ B29-Btk SIN-lentiviral vector specifically promotes Btk expression in B lineage cells, and correction of the Btk-deficient phenotype in vitro and in vivo. Peripheral blood B cells were analyzed for relative IgM and IgD expression at 6 weeks post reconstitution. Representative data from animals receiving mock-vs/ EμB29-Btk transduced marrow are shown. Upper left quadrant shows percentage of circulating mature B cells. Peripheral blood B cells were analyzed for relative IgM and IgD expression at 6 weeks post reconstitution. Representative data from animals receiving mock-vs/ EμB29-Btk transduced marrow are shown. Upper left quadrant shows percentage of circulating mature B cells.

INTRODUCTION The fruit industry employs millions of hectares for production; of these, a significant percentage uses only female or hermaphrodite plants. The selection is carried out by morphological analysis until blooming, which represents an inefficient use of resources. Typically, well-equipped laboratories and trained personnel are required to perform DNA analysis and give valid results1,2. Devices capable of generating this information within a short timespan could contribute to a fast and effective selection of productive plants. Nonetheless, it is necessary to have high sensitivity to differentiate between samples. The objective of this work is the development of an electrochemical and an optical detection system, with high sensitivity and repeatability. With the aim to incorporate the best option in a fully integrated device that ensures an easy-to-use product, safeguarding the correct use by non-trained operators and reducing the time to obtain a result. MATERIALS AND METHODS To evaluate the detection systems a random sequence of DNA (5’-TAGTCGTCAATCCTCCGCTT) was used (50 – 540 ng/µL). The electrochemical detection design is composed by three electrodes (WE-Au, AE-Au, RE-Ag|AgCl) and 0.5 M Ru(NH3)6Cl3 as a DNA intercalating agent3 in 40 mM TAE buffer. Three electrochemical techniques (SWV, DPV and CV) were compared (Bio Logic potentiostat). The optical detection system is composed of a phototransistor (Max. Sens. @ 550 nm), a filter (520 nm) and a LED (Max. WL peak @ 455 nm) to detect the fluorescent DNA intercalator SYBRgreen. Different concentrations of fluorescein (0.005 – 10 µM) were used to evaluate the system capabilities. The system was evaluated with the DNA sequence and SYBRgreen, then compared with a fluorescence microscope (Nikon Eclipse Ti-U). Finally, both systems were tested with plant DNA samples. Genomic material was extracted (CTAB protocol4) form 6 plants (3 female/3 hermaphrodite), amplified by PCR (Thermal cycler miniPCR Amplyus) and analyzed by electrophoresis. RESULTS With the electrochemical detection system, we observed a proportional decrease in the Ru(NH3)6Cl3 signal as the DNA concentration increases, as expected. The data analysis demonstrated that SWV was the most sensitive technique with a R2=0.980, LOD 30.968 ng/µL and LOQ 103.226 ng/µL. Results showed that female plants present an average current of 1.774 μA while hermaphrodite plants had 1.694 μA, allowing us to differentiate hermaphrodite plants accurately with a 90 % confidence interval. On the other hand, in the optical detection system with a R2=0.9568, LOD 2.12 ng/µL and LOQ 7.06 ng/µL, we observed an increase in the signal as de DNA concentration increases. When the optical analysis was compared with the fluorescence microscope results, we observed a similar trend in the signals with a R2=0.995, that validate the functionality of our system. However, the difference between plant samples was detected with only the 70 % confidence interval, female samples showed an average signal of 381 mV while hermaphrodite plants had 352.56 mV. CONCLUSIONS Plant DNA detection was evaluated through two different systems. The optical detection system showed more sensitivity with synthetic samples. However, in the evaluation of plant samples, the electrochemical system is less susceptible to interferences. Therefore, we can differentiate between female and hermaphrodite plants with a 90 % confidence interval. In this way, it represents the best option to evaluate a lab-on-a-chip device. REFERENCES Barrantes-Santamaría W, Loría-Quirós C, Gómez-Alpízar L. Evaluation of two-sex determining systems in papaya plants (Carica papaya) Pococí hybrid. Agron Mesoamerican. 2019;30(2):437-446. doi:10.15517/am.v30i1.34916 Cornelis S. FORENSIC LAB-ON-A-CHIP DNA ANALYSIS. 2019. Li LY, Jia HN, Yu HJ, et al. Synthesis, characterization, and DNA-binding studies of ruthenium complexes [Ru(tpy)(ptn)] 2 + and Ru(dmtpy)(ptn)] 2 +. J Inorg Biochem. 2012;113:31-39. doi:10.1016/j.jinorgbio.2012.03.008 Biosciences. CTAB extraction solution for genomic DNA extraction. Biosciences. 2016:3-7. Figure 1

Investigations to better understand the nature of mass transport and two-phase flow within a polymer electrolyte water electrolyzer (PEWE) have gained popularity as researchers strive to improve system performance and efficiency. Along with traditional polarization experiments, the use of in-situ spatial and temporal current distribution measurement techniques has proven to be very attractive. Different methods for spatial current distribution measurements include the use of resistor networks, potential probes, and printed circuit boards (PCB) [1–3]. Using such techniques, Mench and co-workers have previously demonstrated [4–7] that, under mass transport limited conditions for any combination of flow-field and diffusion media, the current density distributions consistently exhibit a gradient – with high current towards the inlet and low towards the outlet. These contour plots showed certain dissimilarities; however, they serve as a qualitative picture to gauge cell performance and characterize mass transport. Therefore, in this work a robust analysis was developed that provides a quantitative understanding and better characterization of the mass transport limitation within the electrolyzer. A mass transport number (MTN) was defined and used to further characterize the influence of mass transport limitation experienced within an electrolyzer. Applying this new analysis to our the investigations revealed that the PEWE system performance using high-performance micro-patterned Ti-foil liquid-gas-diffusion-layer (LGDL) [8,9] was highly sensitive to the cell architecture and exhibited poor mass transport behavior using traditional channel based flow-fields. Compared with the conventional porous transport layer (PTL) morphology, the lack of in-plane permeability of the LGDLs caused faster onset of mass transport limitations at lower flowrates, local increase in HFR, and poor area utilization. Therefore, a unitized single flow-field-LDGL component that mitigates these problems has been designed. Through this work it will be shown that the flow-field is designed to have pins that allow for greater in-plane transport. The staggered pattern reduces pressure drop and promotes exchange in-between channels that assist in efficient bubble removal. Additionally, the cross-section of the pin, the pitch, and aspect-ratios are adjustable to maximize porosity for different LGDLs. Finally, making this into a single unitized component having a permanently attached LGDL will decrease interfacial contact resistances and improve cell performance (as shown in Figure 1). [1] T. V. Reshetenko, G. Bender, K. Bethune, R. Rocheleau, A segmented cell approach for studying the effects of serpentine flow field parameters on PEMFC current distribution, Electrochim. Acta. 88 (2013) 571–579. https://doi.org/10.1016/j.electacta.2012.10.103. [2] A. Phillips, M. Ulsh, J. Porter, G. Bender, Utilizing a Segmented Fuel Cell to Study the Effects of Electrode Coating Irregularities on PEM Fuel Cell Initial Performance, Fuel Cells. 17 (2017) 288–298. https://doi.org/10.1002/fuce.201600214. [3] C. Immerz, B. Bensmann, P. Trinke, M. Suermann, R. Hanke-Rauschenbach, Local Current Density and Electrochemical Impedance Measurements within 50 cm Single-Channel PEM Electrolysis Cell, J. Electrochem. Soc. 165 (2018) F1292–F1299. https://doi.org/10.1149/2.0411816jes. [4] F.H. Roenning, A. Roy, D. Aaron, M.M. Mench, Spatially-Resolved Current Distribution Measurements in Polymer Electrolyte Water Electrolyzers, ECS Meet. Abstr. MA2020-02 (2020) 2457–2457. https://doi.org/10.1149/MA2020-02382457mtgabs. [5] A. Roy, F. Roenning, D. Aaron, M.M. Mench, Quantifying Lateral Current Spread While Measuring Performance Using a Segmented Polymer Electrolyte Water Electrolysis Cell, ECS Meet. Abstr. MA2020-02 (2020) 2458–2458. https://doi.org/10.1149/MA2020-02382458mtgabs. [6] A. Roy, F. Roenning, D. Aaron, M.M. Mench, Local Two-Phase Flow and Performance in Polymer Electrolyte Water Electrolysis Cells, ECS Meet. Abstr. MA2021-01 (2021) 1190–1190. https://doi.org/10.1149/MA2021-01381190mtgabs. [7] A.Z. Weber, R.L. Borup, R.M. Darling, P.K. Das, T.J. Dursch, W. Gu, D. Harvey, A. Kusoglu, S. Litster, M.M. Mench, R. Mukundan, J.P. Owejan, J.G. Pharoah, M. Secanell, I. V. Zenyuk, A Critical Review of Modeling Transport Phenomena in Polymer-Electrolyte Fuel Cells, J. Electrochem. Soc. 161 (2014) F1254–F1299. https://doi.org/10.1149/2.0751412jes. [8] J. Mo, Z. Kang, S.T. Retterer, D.A. Cullen, T.J. Toops, J.B. Green, M.M. Mench, F.-Y. Zhang, Discovery of true electrochemical reactions for ultrahigh catalyst mass activity in water splitting, Sci. Adv. 2 (2016) e1600690. https://doi.org/10.1126/sciadv.1600690. [9] Y. Li, Z. Kang, X. Deng, G. Yang, S. Yu, J. Mo, D.A. Talley, G.K. Jennings, F.-Y. Zhang, Wettability effects of thin titanium liquid/gas diffusion layers in proton exchange membrane electrolyzer cells, Electrochim. Acta. 298 (2019) 704–708. https://doi.org/10.1016/j.electacta.2018.12.162. Figure 1

Abstract Background: Prognosis is dismal for older patients (pts) with R/R AML, especially if multiple lines of AML treatment (Tx) have failed. Attaining response is more difficult after each Tx failure, and many pts cannot tolerate high-intensity salvage chemotherapy regimens. IDH2 mutations occur in ~8-19% of pts with AML. ENA is an oral IDH2 inhibitor approved for Tx of adult pts with m IDH2 R/R AML. The phase 3, randomized IDHentify trial compared ENA monotherapy vs. conventional care regimens (CCR)-intermediate-dose cytarabine (IDAC), low-dose cytarabine (LDAC), azacitidine (AZA), or best supportive care (BSC) only-in older pts with late-stage m IDH2 R/R AML who had received multiple prior AML Tx. Reported here are clinical outcomes for pts in IDHentify who were preselected to one of the lower-intensity CCR options (LDAC, AZA, or BSC only) before randomization to ENA or CCR. Methods: This international, multicenter, open-label trial enrolled pts aged ≥60 yrs with ECOG PS ≤2 and m IDH2 AML R/R to 2-3 prior AML Tx. Before randomization, pts were preselected to AZA 75 mg/m 2/day (d) ×7d, IDAC 0.5-1.5 g/m 2 ×3-6d, LDAC 20 mg BID ×10d, or BSC only. Pts were then randomized 1:1 to receive ENA (100 mg QD) or CCR in repeated 28d Tx cycles; pts randomized to CCR received their preselected Tx. All pts could receive BSC. These post hoc analyses include pts preselected to lower-intensity AZA, LDAC, or BSC only. Endpoints included overall response rate (ORR: complete remission [CR], CR with incomplete recovery [CRi/CRp], partial response [PR], or morphologic leukemia-free state [MLFS], per IWG 2003 AML response criteria), rates of hematologic improvement (HI) and transfusion independence (TI) (IWG 2006 MDS criteria), overall survival (OS), event-free survival (EFS), and time to Tx failure (TTF). OS was assessed in the intent-to-treat (ITT) population and among efficacy-evaluable (E-E) pts who received ≥1 study drug dose and had ≥1 response evaluation on-Tx. Results: In all, 267 (84%) of 319 enrolled pts were preselected to a lower-intensity Tx regimen and then randomized 1:1 to receive ENA (n = 139) or their preselected CCR (n = 128: AZA 69, LDAC 37, BSC 22). At data cutoff (17-Mar 2020), 10 ENA pts and 4 CCR pts continued to receive their assigned Tx. Median Tx durations were 143d (range 3-1270) in the ENA arm and 49d (1-1166) in the CCR arm; 15 CCR pts (12%) and 1 ENA pt discontinued before receiving assigned Tx. After discontinuing Tx, 43 ENA pts (31%) and 52 CCR pts (41%) received subsequent AML Tx, including 12 CCR pts (9%) who received commercially available ENA. Baseline (BL) characteristics were generally similar between Tx arms. Median age overall was 72 yrs (range 60-86), 80% of pts had received 2 prior AML Tx, 61% had ELN adverse-risk AML, 41% had primary refractory AML (ie, never attained CR/CRi/CRp), and 63% and 51% of pts were RBC and platelet transfusion-dependent (TD), respectively. Among all pts preselected to a lower-intensity Tx (ITT), ORR was substantially greater with ENA vs CCR (41% vs 11%, respectively), as were rates of CR (26% vs 3%) and HI (41% vs 13%) (P < 0.001, all comparisons) (Table), and proportionally more pts in the ENA arm achieved or sustained RBC and platelet TI (Table). OS was prolonged with ENA vs CCR (HR 0.74 [95% CI 0.56, 0.97]; P = 0.029), with a late separation of the curves after median OS had been reached (median OS 6.8 vs 6.2 mo, respectively), and 1-yr survival rates were 41% vs 26% (∆15.0% [3.4%, 26.6%]). Among E-E pts (ENA, n = 133; CCR, n = 110), OS was improved with ENA (HR 0.70 [0.53, 0.93]; P = 0.013): median OS was 6.9 mo, vs 5.7 mo with CCR. EFS and TTF in the ITT population were also prolonged with ENA vs CCR (Table). The safety of ENA in this pt subgroup was similar to that for all ENA-randomized pts and consistent with previous findings (Stein 2019). ENA-related differentiation syndrome occurred in 13% of pts and hyperbilirubinemia in 26% of pts. Conclusions: In pts with late-stage m IDH2 R/R AML, ENA was associated with clinically meaningful improvements in morphologic response, HI, RBC and platelet TI, and survival compared with conventional lower-intensity Tx options. OS outcomes were potentially confounded by the substantial number of pts randomized to CCR who did not receive Tx or discontinued Tx early, and by extensive use of subsequent Tx (including ENA) during follow-up. These clinical benefits support use of ENA as an appropriate oral outpatient Tx for pts with m IDH2 R/R AML who are not candidates for intensive therapies. Figure 1 Figure 1. Disclosures DiNardo: Forma: Honoraria, Research Funding; ImmuneOnc: Honoraria, Research Funding; Notable Labs: Current holder of stock options in a privately-held company, Membership on an entity's Board of Directors or advisory committees; Foghorn: Honoraria, Research Funding; Bristol Myers Squibb: Honoraria, Research Funding; GlaxoSmithKline: Membership on an entity's Board of Directors or advisory committees; Takeda: Honoraria; Novartis: Honoraria; AbbVie: Consultancy, Research Funding; Agios/Servier: Consultancy, Honoraria, Research Funding; Celgene, a Bristol Myers Squibb company: Honoraria, Research Funding. Montesinos: Pfizer: Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Sanofi: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Daiichi Sankyo: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Incyte: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Novartis: Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Agios: Consultancy; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Karyopharm: Membership on an entity's Board of Directors or advisory committees, Research Funding; Tolero Pharmaceutical: Consultancy; Stemline/Menarini: Consultancy; Forma Therapeutics: Consultancy; Janssen: Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Teva: Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Glycomimetics: Consultancy; AbbVie: Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Astellas Pharma, Inc.: Consultancy, Honoraria, Other: Advisory board, Research Funding, Speakers Bureau. Schuh: Kite/Gilead: Research Funding; GlycoMimetics: Research Funding; Servier: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Agios: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bristol-Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Astellas: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; AbbVie: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Jazz: Membership on an entity's Board of Directors or advisory committees; Teva: Honoraria, Membership on an entity's Board of Directors or advisory committees. Papayannidis: AbbVie: Honoraria; Astellas: Honoraria; Janssen: Honoraria; Amgen: Honoraria; Pfizer: Honoraria; Novartis: Honoraria. Vyas: AbbVie: Consultancy, Honoraria; Novartis: Honoraria; Daiichi Sankyo: Honoraria; Jazz: Honoraria; Pfizer: Honoraria; Takeda: Honoraria; Astellas: Consultancy, Honoraria; Gilead: Honoraria; Bristol Myers Squibb: Consultancy, Honoraria, Research Funding; Janssen: Honoraria. Wei: Novartis, Celgene, AbbVie, Servier, AstraZeneca, and Amgen: Research Funding; Novartis, Janssen, Amgen, Roche, Pfizer, Abbvie, Servier, BMS, Macrogenics, Agios, Gilead: Membership on an entity's Board of Directors or advisory committees; Astellas: Honoraria. Zeidan: Daiichi Sankyo: Consultancy; Epizyme: Consultancy; Genentech: Consultancy; Gilead: Consultancy, Other: Clinical Trial Committees; Kura: Consultancy, Other: Clinical Trial Committees; AbbVie: Consultancy, Other: Clinical Trial Committees, Research Funding; BMS: Consultancy, Other: Clinical Trial Committees, Research Funding; Geron: Other: Clinical Trial Committees; ADC Therapeutics: Research Funding; Acceleron: Consultancy, Research Funding; Amgen: Consultancy, Research Funding; Boehringer Ingelheim: Consultancy, Research Funding; BioCryst: Other: Clinical Trial Committees; Novartis: Consultancy, Other: Clinical Trial Committees, Travel support, Research Funding; Cardiff Oncology: Consultancy, Other: Travel support, Research Funding; BeyondSpring: Consultancy; Pfizer: Other: Travel support, Research Funding; Agios: Consultancy; Jazz: Consultancy; Janssen: Consultancy; AstraZeneca: Consultancy; Ionis: Consultancy; Aprea: Consultancy, Research Funding; Astellas: Consultancy; Loxo Oncology: Consultancy, Other: Clinical Trial Committees; Jasper: Consultancy; Astex: Research Funding; Incyte: Consultancy, Research Funding. Bluemmert: Bristol Myers Squibb: Current Employment. Yu: Bristol Myers Squibb: Current Employment, Current equity holder in publicly-traded company. Hasan: Bristol Myers Squibb: Current Employment. Martin-Regueira: Bristol Myers Squibb: Current Employment, Current equity holder in publicly-traded company, Divested equity in a private or publicly-traded company in the past 24 months. de Botton: Pfizer: Consultancy; Jazz: Consultancy; Novartis: Consultancy; Daiichi: Consultancy; Abbvie: Consultancy; Astellas: Consultancy; Forma: Consultancy, Honoraria; Agios: Consultancy, Honoraria; Celgene: Consultancy.

In this paper, seismic activity characteristics in the East Sea area was analyzed by authors on the base of the unified earthquake catalog (1900-2017), including 131505 events with magnitude 3 ≤ Mw ≤ 8.4. The seismic intensity in the East Sea during the period 1900-2017 is characterized by the earthquake representative level Mw = 4.7. The strong earthquake activity in the East Sea area clearly shows the regularity in each stage. In the period from 1900 to 2017, the East Sea area has four periods of strong earthquake activity, each stage is nearly 30 years with particular characteristics. The distribution of the maximum earthquake quantities by years has a cyclicity in all four periods. In each stage there are 1-2 strong earthquakes with Mmax ≥ 8.0. The strong earthquakes with Mmax ≥ 7.5 have occurred by a repeatable rule of 3-5 years in all four stages. This allows the prediction of the maximum earthquake repeat cycle of Mmax ≥ 7.5 in the study area is 3-5 years. In other hand, the maximum magnitude values for the East Sea region has assessed by GEV method with several different predict periods (20, 40, 60, 80, 100 years), with predicted probability 80%. We concluded that it is possible that earthquake have Mmax = 8.7 will occur in next 100 years.ReferencesBautista C.B., Bautista M.L.P., Oike K., Wu F.T., Punongbayan R.S., 2001. A new insight on the geometry of subducting slabs in northern Luzon, Philippines. Tectonophysics, 339, 279-310.Bui Cong Que, et al., 2010. Seismic and tsunamis hazard in coastal Viet Nam. Natural Science and Technology Publishing House, 311p.Bui Van Duan, Nguyen Cong Thang, Nguyen Van Vuong, Pham Dinh Nguyen, 2013. The magnitude of the largest possible earthquake in the Muong La-Bac Yen fault zone. J. Sci. of the Earth, 35, 53-59 (in Vietnamese).Cao Dinh Trieu, Pham Nam Hung, 2008. Deep-seated fault zone presents the risk of strong earthquakes in the East and South Vietnam Sea. Scientific Report of the First National Conference on Marine Geology, Ha Long, October, 9-10, 491-497.Hsu Ya-Ju, Yu Shui Ben, Song Teh.-Ru Alex, Bacolcol Teresito, 2012. Plate coupling along the Manila subduction zone between Taiwan and northern Luzon. J. Asian Earth Sci., 51, 98-108.http://www.ioc-tsunami.org/index.php?option=com_oe&task=viewDocumentRecord&docID=16478.http://www.jcomm.info/index.php?option=com_oevàtask=viewDocumentRecordvafdocID=16484.Kirby S., Geist E., Lee W.H., Scholl D., Blakely, R., October 2005. 660 Tsunami source characterization for western Pacific subduction 661 zones: a perliminary report. Report, USGS Tsunami Subduction 662 Source Working Group.Le Duc Anh, Nguyen Hoang., Shakirov RB., Tran T.H., 2017. Geochemistry of late miocene-pleistocene basalts in the Phu Quy island area (East Vietnam Sea): Implication for mantle source feature and melt generation, Vietnam J. Earth Sci., 39, 270-288.Le Huy Minh, Frederic Masson, Alain Bourdiilon, Patrick Lassudrie Duchesne, Rolland Fleury, Jyr-ching Hu, Vu Tuan Hung, Le Truong Thanh, Nguyen Chien Thang, Nguyen Ha Thanh, 2014. GPS data continuously in Vietnam and Southeast Asia. J. Sci. of the Earth, 36, 1-13.Le Van De, 1986. Outline of tectonics of the East Vietnam sea and adjacent areas. Proc. 1st Conf. Geol. Indoch., Ho Chi Minh City, 397-404, Hanoi.Ngo T.L., Tran V.P., 2013. Development of a new algorithm for the separation of seismic and anemone groups from the earthquake list to ensure the independence of events. Journal of Marine Science and Technology, Hanoi, 13(3A), 79-85.Nguyen Dinh Xuyen., et al., 2007. Report on the implementation of the task "Earthquake scenarios for tsunamis in the South China Sea". Institute of Meteorology and Hydrology.Nguyen Hong Phuong, 2015. Estimation of seismic hazard parameters for potential tsunami genic sources in the South China Sea region.Nguyen Hong Phuong, 2001. Probabilistic Seismic Hazard Assessment Along the Southeastern Coast of Vietnam, Natural Hazards, 24, 53-74.Nguyen Hong Phuong, 2004. Earthquake risk map of Vietnam and East Sea. J. Sci. of the Earth, 26, 97-111.Nguyen Hong Phuong, Bui Cong Que, 2012. Investigation of earthquake tsunami sources, capable of affecting Vietnamese coast, Nat Hazards, 64, 311-327.Nguyen Hong Phuong, Pham The Truyen, 2014. Probabilistic Seismic Hazard Assessment for the South Central Vietnam. J. Sci. of the Earth, 36, 451-461.Nguyen Hong Phuong, Pham The Truyen, Nguyen Ta Nam, 2017. Probabilistic Seismic Hazard Assessment for the Tranh River hydropower plant No2 site, Quang nam province, Vietnam J. Earth Sci., 38(2), 188-201.Nguyen Van Luong, Bui Cong Que, Nguyen Van Duong, 2008. Tectonic stresses and modern movements in the crust of the Earth in the East Sea area, Journal of Marine Science and Technology, 46-52.Nguyen Van Luong, Duong Quoc Hung, Bui Thi Thanh and Tong Duy Cuong, 2003. Characteristics of fault systems in the East Sea area. J. Sci. of the Earth., 25, 1-8 (in Vietnamese).Nguyen Van Luong, et al., 2002. Result of establishment of the list of earthquake dynamics in the East Sea area, studies on geology and marine geophysics, VII, Hanoi.Nguyen Van Luong, et al., 2008. Tectonic seismic and geodynamic features of the South China Sea, Proceedings of the 1st National Conference on Marine Geology and Sustainable Development, 9-10, Ha Long, 498-509.Pham Van Thuc and Nguyen Thi Kim Thanh, 2004. Earthquake zone in the South China Sea and coastal areas. Journal of Geology, A series, 285, 11-12.Pham Van Thuc, 2001, Characteristics of tsunamis in the East Sea region of Vietnam. TC and CNN, TI, 2, 52-64.Phan Trong Trinh, Ngo Van Liem, Vy Quoc Hai, John Beavan, Nguyen Van Huong, Hoang Quang Vinh, Bui Van Thom, Nguyen Quang Xuyen, Nguyen Dang Tuc, Dinh Van Thuan, Nguyen Trong Tan, Nguyen Viet Thuan, Le Huy Minh, Bui Thi Thao. Nguyen Huy Thinh, Dinh Van The, Le Minh Tung, Tran Quoc Hung, Nguyen Viet Tien, 2010b. Modern tectonic movement in the East Sea and surrounding areas. Journal of Geology. Series A, 320, 9-10, Hanoi.Phan Trong Trinh, 2006. The Tsunami and December 26, 2004 in the Indian Ocean: A Warning to Vietnam. Journal of Geology, Series A, 293, Hanoi.Phan Trong Trinh, et al., 2010a. Research on the tectonic activity, modern tectonics and geodynamics of the South China Sea as a scientific basis for forecasting the types of catastrophe involved and proposed solutions prevent. KC.09.11/06-10. Institute of Geology, 446p.Phan Trong Trinh, Nguyen Van Huong, Ngo Van Liem, Tran Dinh To, Vy Quoc Hai, Hoang Quang Vinh, Bui Van Thom, Nguyen Quang Xuyen, Nguyen Viet Thuan, Bui Thi Thao, 2011. Geological and geological hazards in Vietnam's sea and nearby. J. Sci. of the Earth, 33, 443-456.Pisarenko V.F., Sornette A., Sornette D. and Rodkin M.V, 2008. New approach to the Characterization of Mmax and of the Tail of the Distribution of Earthquake Magnitudes. Pure and Applied Geophysics, 165, 847-888.Pisarenko V.F, Sornette D. and Rodkin M.V., 2010. Distribution of maximum Earthquake magnitudes in future time intervals: application to the seismicity of Japan (1923-2007). EPS (Earth, Planets and Space), 62, 567-578.Pisarenko V.F., Rodkin M.V, and Rukavishnikova T.A., 2014. Estimation of the Probability of Strongest Seismic Disasters Based on the Extreme Value Theory. Physics of the Solid Earth, 50(3), 311-324.Pisarenko V.F., Rodkin M.V. and et al., 2012. New general quantile approach to the seismic rick assessment application to the Vietnam region. //Proceedings of the International Conference on "Geophysics - Cooperation and Sustainable Development." Science and Technology Publishing House. Hanoi, 161-167.Vu Thanh Ca, 2008. Report on the project to build a map of tsunami warning for coastal areas of Vietnam. Institute of Hydrometeorology and Environment - Ministry of Natural Resources and Environment.Yingchun Liu, Angela Santos, Shuo M. Wang, Yaolin Sh, Hailing Liu, David A. Yuen, 2007. Tsunami hazards along Chinese coast from potential earthquakes in the South China Sea. Phys. Earth Planet. Interiors, 163, 233-244.Zhiguo Xu, 2015. Seismicity and Focal mechanisms in the South China Sea Region and its Tectonic Significances.

Ключові слова: релігійні свята, Уманська округа, місцева преса, радянська влада, 1923–1925 роки, антирелігійна політика.
 Анотація
 У статті розглядається офіційне ставлення партійних, державних, громадських структур в Уманській окрузі до релігійних свят у 1923–1925 рр. Проаналізовані відповідні матеріали вміщені на сторінках газети «Робітниче-селянська правда» – органу Уманського окружного комітету КП(б)У і окрвиконкому Уманщини.
 Зроблено висновок, що в Уманській окрузі, як і загалом в радянській Україні у той період, відносно більш толерантне офіційне ставлення до релігії поєднувалося із подальшим насадженням нетерпимості до неї. Це досить виразно виявлялося в неприйнятті релігійних свят та всього пов’язаного з ними і вело до руйнації традиційних духовно-культурних цінностей тих релігійних конфесій, які були представлені у цьому регіоні.
 Посилання
 «Seider», 1923 – «Seider» y «Tainaia vecheria» ["Seider" and "The Last Supper"] // Robitnyche-selianska pravda. 1923. 22 bereznia. № 63. S. 2. Pidpys: F. N. [in Ukrainian].
 Antyrelihiina propahanda, 1923 – Antyrelihiina propahanda v s. Tanskomu [Anti-religious propaganda in the village of Tanske] // Robitnyche-selianska pravda. 1923. 11 kvitnia. № 78. S. 3 Pidpys: V. B. [in Ukrainian].
 Antyrelihiina propahanda, 1924 – Antyrelihiina propahanda v s. Taliankakh [Anti-religious propaganda in the village of Talianki] // Robitnyche-selianska pravda. 1924. 16 sichnia. № 9. S. 2. Pidpys: M. [in Ukrainian].
 Babenko, 2010 – Babenko L. Osoblyvosti antyrelihiinoi propahandy 1920-kh rokiv ta yii alternatyvy [Features of anti-religious propaganda of the 1920s and its alternatives] // Filosofski obrii. 2010. № 24. S. 222–235. URL: http://dspace.nbuv.gov.ua/bitstream/handle/123456789/25951/18-Babenko.pdf?sequence=1 [in Ukrainian].
 Baidachenko, 1925 – Baidachenko H. Proty Peruna y Khrysta – elektryka y radio [Against Perun and Christ – electricity and radio] // Robitnyche-selianska pravda. 1925. 31 hrudnia. № 298. S. 3 [in Ukrainian].
 Bezbozhnyk, 1923 – Relihiina dyskusiia v s. Nesterivtsi [Religious discussion in the village of Nesterivka] // Robitnyche-selianska pravda. 1923. 29 kvitnia. № 94. S. 2. Pidpys: Bezbozhnyk [in Ukrainian].
 Bliau, 1923 – Bliau D. Blahochestyvыe masloboishchyky [Pious chippers] // Robitnyche-selianska pravda. 1923. 16 travnia. № 107. S. 4 [in Russian].
 Bondarchuk, 1925 – Relihiinyi durman ta babski zabobony [Religious dope and women superstitions] // Robitnyche-selianska pravda. 1925. 5 liutoho. № 28. S. 2. Pidpys: Bondarchuk [in Ukrainian].
 Borotba komnezamu, 1923 – Borotba komnezamu s. Kniazhykiv z relihiinymy zabobonamy [The struggle of the komnezam of the village of Knyazhyky with religious prejudices] // Robitnyche-selianska pravda. 1923. 29 kvitnia. № 94. S. 2. Pidpys: B. [in Ukrainian].
 Brusianin, 1925 – Brusianin V. Komu potribni relihiini sviata? [Who needs religious holidays?] // Robitnyche-selianska pravda. 1925. 12 kvitnia. № 83. S. 1 [in Ukrainian].
 Vecher antyrelyhyoznoi propahandы, 1923 – Vecher antyrelyhyoznoi propahandы v teatre «Kommuna» [An evening of anti-religious propaganda at the Kommuna theater] // Robitnyche-selianska pravda. 1923. 11 kvitnia. № 78. S. 3. Pidpys: D. [in Russian].
 Vecher v klube, 1923 – Vecher v klube polyhrafystov [Evening at the club of printers] // Robitnyche-selianska pravda. 1923. 4 kvitnia. № 74. S. 2. Pidpys: D. [in Russian].
 Vidhadai, 1923 – Bez boha khlib matymesh, a z bohom torbu chipliatymesh [Without God you will have bread, and with God you will cling to a bag] // Robitnyche-selianska pravda. 1923. 15 veresnia. № 209. S. 3. Pidpys: Selkor Vidhadai [in Ukrainian].
 Vitrynska, 2016 – Vitrynska O. V. Polityka radianskoi vlady shchodo yudaizmu v Ukraini v 1921–1929 rokakh. [The policy of the Soviet government towards Judaism in Ukraine in 1921–1929] Dys… kand. ist. nauk. Poltava, 2016. 254 s. URL: https://shron1.chtyvo.org.ua/Vitrynska_Olena/Polityka_radianskoi_vlady_schodo_iudaizmu_v_Ukraini_v_1921–1929_rokakh.pdf [in Ukrainian].
 Volska, 1925 – Ne derzhit uchniv vdoma v relihiini sviata [Do not keep students at home on religious holidays] // Robitnyche-selianska pravda. 1925. 19 hrudnia. № 290. S. 3. Pidpys: Selkorka Volska [in Ukrainian].
 Haievska, 2013 – Haievska T. Derzhavni radianski sviata: istoryko-kulturolohichnyi aspekt [State Soviet holidays: historical and cultural aspect] // Kulturolohichna dumka. 2013. № 6. S. 153–159. URL: http://nbuv.gov.ua/UJRN/ Kultdum_2013_6_21 [in Ukrainian].
 Demennyi, 1923 – Shkola s. Kamianechoho boretsia z relihiinymy zabobonamy [School in the village of Kameneche struggles religious prejudices] // Robitnyche-selianska pravda. 1923. 14 kvitnia. № 81. S. 2. Pidpys: Demennyi [in Ukrainian].
 Didus, 1923 – Antyrelihiina propahanda na paskhalni sviata v s. Hromakh [Anti-religious propaganda on Easter holidays in the village of Gromy] // Robitnyche-selianska pravda. 1923. 4 kvitnia. № 74. S. 2. Pidpys Didus [in Ukrainian].
 Yev. Hen, 1924 – Shcho take sviato rizdva? [What is a Christmas holiday?] // Robitnyche-selianska pravda. 1924. 25 hrudnia. № 225. S. 2. Pidpys: Yev. Hen [in Ukrainian].
 Zakrepym pobedu, 1923 – Zakrepym pobedu [Let's consolidate the victory] // Robitnyche-selianska pravda. 1923. 4 kvitnia. № 74. S. 1 [in Russian].
 K antyrelyhyoznoi propahande, 1923 – K antyrelyhyoznoi propahande v paskhalnыe dny [To anti-religious propaganda on Easter days] // Robitnyche-selianska pravda. 1923. 24 bereznia. № 65. S. 1 [in Russian].
 K Komsomolskoi paskhe, 1923 – K Komsomolskoi paskhe [For Komsomolskaya Easter] // Robitnyche-selianska pravda. 1923. 29 bereznia. № 69. S. 3 [in Russian].
 Kak obmanыvaiut, 1923 – Kak obmanыvaiut Yehovu [How Jehovah is Deceived] // Robitnyche-selianska pravda. 1923. 1 kvitnia. № 72. S. 2 [in Russian].
 Kyrydon, 2017 – Kyrydon A. M. Indoktrynatsiia radianskosti: obriadovo-sviatkovyi kanon yak marker formuvannia ateizovanoho suspilstva (1920–1930-i rr.) [The indoctrination of Sovietness: a ceremonial-festive canon as a marker of the formation of an atheistic society (1920s–1930s)] // Umanska starovyna. 2017. Vypusk 3. S. 5–20. URL: http://www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?I21DBN=LINK&P21DBN=UJRN&Z21ID=&S21REF=10&S21CNR=20&S21STN=1&S21FMT=ASP_meta&C21COM=S&2_S21P03=FILA=&2_S21STR=umanst_2017_3_3 [in Ukrainian].
 Labenskyi, 1924 – S. Kniazhyky [The village of Knyazhiki] // Robitnyche-selianska pravda. 1924. 6 serpnia. № 107. S. 3. Pidpys: Labenskyi [in Ukrainian].
 Litstudiia, 1925 – Litstudiia «Pluhu» pry Umanskim Ahrotekhnikumi [Litstudio "Plow" at Uman Agricultural College] // Robitnyche-selianska pravda. 1925. 15 kvitnia. № 85. S. 2. Pidpys: P. K. [in Ukrainian].
 Makukha, 1923 – Borotba z relihiinymy zabobonamy v s. Pidvysokomu [Struggle against religious prejudices in the village of Pidvysoke] // Robitnyche-selianska pravda. 1923. 29 kvitnia. № 94. S. 2. Pidpys: Makukha [in Ukrainian].
 Matukhno, 2017 – Matukhno Yu. O. Problema klasyfikatsii radianskykh sviat u pershe porevoliutsiine desiatylittia [The problem of classifying Soviet holidays in the first post-revolutionary decade] // Naukovi pratsi istorychnoho fakultetu Zaporizkoho natsionalnoho universytetu. 2017. Vyp. 48. S. 139–142. URL: http://www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?C21COM=2&I21DBN=UJRN&P21DBN=UJRN&IMAGE_FILE_DOWNLOAD=1&Image_file_name=PDF/Npifznu_2017_48_27.pdf
 Medsanrabotnyky, 1923 – Medrabotnyky ne otstaiut [Medical workers are not lagging behind] // Robitnyche-selianska pravda. 1923. 6 kvitnia. № 76. S. 2 [in Russian].
 Na obshchem sobranyy, 1923 – Na obshchem sobranyy transportnykov y stroytelei [At a general meeting of transport workers and builders] // Robitnyche-selianska pravda. 1923. 31 bereznia. № 71. S. 3 [in Ukrainian].
 Naiblyzhchi zavdannia, 1924 – Naiblyzhchi zavdannia raionnykh komisii po protyrelihiinii propahandi [Immediate tasks of district commissions for anti-religious propaganda] // Robitnyche-selianska pravda. 1924. 11 sichnia. № 7. S. 3 [in Ukrainian].
 Novoselytskyi, 1923 – Novoselytskyi F. Stradaiushchye y voskresaiushchye bohy y yskuplenye ymy liudskykh hrekhov [Suffering and resurrecting gods and their atonement for human sins] // Robitnyche-selianska pravda. 1923. 20 bereznia. № 61. S. 2 [in Russian].
 Paskhalnaia kampanyia, 1923 – Paskhalnaia kampanyia [Easter campaign] // Robitnyche-selianska pravda. 1923. 28 bereznia. № 68. S. 3 [in Russian].
 Polytprosvet, 1923 – Prazdnyk Paskhy y paskhalnыe obriadы [Easter holiday and Easter ceremonies] // Robitnyche-selianska pravda. 1923. 20 bereznia. № 61. S. 2. Pidpys: Polytprosvet Ukoma KSM [in Russian].
 Polishchuk, 2009 – Polishchuk V. Onoprii Turhan – zhurnalist i pysmennyk [Onopriy Turgan is a journalist and writer] URL: https://umanliteratura.ucoz.ua/news/v_polishhuk_onoprij_turgan_zhurnalist_i_pismennik/2010-12-20-256 [in Ukrainian].
 Popova, 1925 – Popova O. Sviatkuimo ne bozhi sviata, a sviata pratsi y peremohy [Let us celebrate not God's holidays, but the holidays of work and victory] // Robitnyche-selianska pravda. 1925. 12 kvitnia. № 83. S. 2 [in Ukrainian].
 Proletshkola, 1923 – Proletshkola protyv boha [Proletarian school against god] // Robitnyche-selianska pravda. 1923. 28 bereznia. № 68. S. 2 [in Russian].
 Rabkor, 1923 – Budem borotsia s relyhyei kak y s vooruzhennыm vrahom [We will fight religion like an armed enemy] // Robitnyche-selianska pravda. 1923. 3 kvitnia. № 73. S. 3. Pidpys: Rabkor K. [in Ukrainian].
 Rabota ahytpropa, 1923 – Rabota ahytpropa v aprele [Agitprop work in April] // Robitnyche-selianska pravda. 1923. 9 travnia. № 101. S. 3 [in Russian].
 Robitnyk, 1924 – Osvitu zhintsi na seli [Education for a woman in the countryside] // Robitnyche-selianska pravda. 1924. 8 liutoho. № 18. S. 3. Pidpys: Robitnyk [in Ukrainian].
 Robitnyche zhyttia, 1924 – Robitnyche zhyttia [Working life] // Robitnyche-selianska pravda. 1924. 23 kvitnia. № 48. S. 3 [in Ukrainian].
 Sylantiev, 2005 – Sylantiev V. I. Vlada i pravoslavna tserkva v Ukraini (1917–1930 rr.) [Authorities and the Orthodox Church in Ukraine (1917–1930)] Avtoref. dys… dokt. ist. nauk. Kharkiv, 2005. 46 s. [in Ukrainian].
 Syrotiuk, 1924 – Zubrytskyi KNS ne porvav shche z relihiieiu [The Zubrytsia CРР has not yet broken with religion] // Robitnyche-selianska pravda. 1924. 5 sichnia. № 4. S. 2. Pidpys: Syrotiuk [in Ukrainian].
 Sidorenko, 1923 – Sidorenko Z. Neobkhidna chystka komnezamu s. Pobiinoi [It is necessary to clean the komnezam of the village of Pobiyna] // Robitnyche-selianska pravda. 1923. 19 kvitnia. № 85. S. 2 [in Ukrainian].
 Soloviov, 1924 – Soloviov D. Nebazhane yavyshche [An undesirable phenomenon] // Robitnyche-selianska pravda. 1924. 16 sichnia. № 9. S. 2 [in Ukrainian].
 Tabel, 1924 – Tabel sviat i nerobochykh dniv. Oboviazkova postanova Kyivskoho hubvykonkomu № 49 vid 19 bereznia 1924 roku [Table of holidays and non-working days. Mandatory Resolution of the Kyiv Provincial Executive Committee № 49 of March 19, 1924] // Vistnyk Kyivskoho hubvykonkomu. 1924. 2 kvitnia. № 14. S. 2 [in Ukrainian].
 Tarapon, 2016 – Tarapon O. Derzhavni sviata v Ukraini 1920–1930-kh rr. yak zasib formuvannia radianskykh politychnykh tsinnostei [Public holidays in Ukraine in the 1920s and 1930s as a means of forming Soviet political values] // Aktualni pytannia humanitarnykh nauk: mizhvuzivskyi zbirnyk naukovykh prats molodykh vchenykh Drohobytskoho derzhavnoho pedahohichnoho universytetu imeni Ivana Franka. Drohobych, 2016. Vyp. 15. S. 96–102. URL: http://nbuv.gov.ua/UJRN/apgnd_2016_15_13 [in Ukrainian].
 Tolko 40 pyshchevykov, 1923 – Tolko 40 pyshchevykov ne odurachenы relyhyei [Only 40 food workers are not fooled by religion] // Robitnyche-selianska pravda. 1923. 31 bereznia. № 71. S. 3 [in Russian].
 Turhan, 1924 – Turhan O. Proty staroho rizdva [Against old Christmas] // Robitnyche-selianska pravda. 1924. 24 hrudnia. № 224. S. 2 [in Ukrainian].
 Fiialko, 1923 – Fiialko S. Antyrelihiina propahanda v s. Ksendzivtsi [Anti-religious propaganda in the village of Ksendzivka] // Robitnyche-selianska pravda. 1923. 19 kvitnia. № 85. S. 2 [in Ukrainian].
 Flerovskyi, 1923 – Flerovskyi Y. Stradaiushchyi, umershyi y voskresshyi... [Suffering, dead and resurrected...] // Robitnyche-selianska pravda. 1923. 6 kvitnia. № 76. S. 3 [in Russian].
 Flierovskyi, 1925 – Flierovskyi I. Zvidky pishly tserkovni sviata [Where did the church holidays come from?] // Robitnyche-selianska pravda. 1925. 10 kvitnia. № 81. S. 2 [in Ukrainian].
 Tserkvy, 1923 – Tserkvy, kostelы, synahohy – pod klubы y teatrы [Churches, churches, synagogues - for clubs and theaters] // Robitnyche-selianska pravda. 1923. 6 kvitnia. № 76. S. 2 [in Russian].
 Chuchalin, 2019 – Chuchalin O. P. Vplyv ateistychnoi propahandy radianskoi presy na relihiinu sytuatsiiu v USRR u 1920–1930-ti rr. [The influence of atheistic propaganda of the Soviet press on the religious situation in the USSR in the 1920s and 1930s] // Hileia: naukovyi visnyk. 2019. Vypusk 142(1). S. 182–188. URL: http://www.irbis-nbuv.gov.ua/cgi- bin/irbis_nbuv/cgiirbis_64.exe?I21DBN=LINK&P21DBN=UJRN&Z21ID=&S21REF=10&S21CNR=20&S21STN=1&S21FMT=ASP_meta&C21COM=S&2_S21P03=FILA=&2_S21STR=gileya_2019_142(1)__39 [in Ukrainian].
 Yunenko, 1925 – Yunenko S. Nash KNS [Our СPP] // Robitnyche-selianska pravda. 1925. 16 sichnia. № 9. S. 3 [in Ukrainian].

Este trabajo revela los problemas, retos, desafíos y contradicciones de los maestros indígenas del municipio de Chamula, del Estado de Chiapas, México, durante sus prácticas en las aulas en el nivel de educación primaria. Asimismo, da cuenta de cómo un grupo de docentes organizados, desde el proyecto Milpas Educativas, hacen un esfuerzo por llevar una educación distinta basada en el Método Inductivo Intercultural acuñado por Jorge Gasché, en el que plantea un proceso pedagógico significativo para la alfabetización en la lengua de la comunidad, articulando la pedagogía con una posición política, didáctica, jurídica y pertinente.
 Tsos-k’op
 Li amtel lie chal sventa sk’oplal, k’uyepal k’opetik oy yu unik li a’k chan junetik tas lumal chamoetik, tas lumal Chiapas, México, ja’ no ox tok li chanjunetik ta primaria. Oy la uni jun chop ta ak’ chanjunetik ta las pasik jun a’mtelal ti lek la ta nopesel xchiuk la ja oy jun winik ti snaoj smelolal k’uselan ta nopel, schanuptasel ta ololetik taj lumaltik, ja suy “nopesel ta choptik”, ti oyuk smelolal li k’uselan stak ak’el ta a chanop jun ololetike, jech stok taj am’tele ja la yich’oj tas venta Jorge Gasché, taj winike ja staoj ta to ku’lanel, yiloj ti lek ta am’telanel tas stojolal ti ololetik, yu un las tok’olanik tis melolal k’uslejal chanjun taj lumaltik. Cha al toj ep sk’oplal taj am’te le, oy smelolal ja’ no’ox sk’an ta nopesel.

Abstract: Corrosion of biomedical implants is a risk for safe applications of metals for healing in the body. Therefore, for implants that are designed to be permanent (in contrast to biodegradable implants), highly corrosion resistant metals and alloys are used—most notably titanium and its alloys. This perspective discusses a paper that reported on the corrosion behavior of a number of Ti-based implant alloys, from a viewpoint of materials science and a detailed mechanistic understanding of passivity.

This article develops a combined solid phase extraction (SPE) and gas chromatography – mass spectrometry (GC-MS) procedure for determining amphetamine-type stimulants Amphetamine (AM) and Methamphetamine (MA) in human hair. Hair samples were incubated in methanol containing 1% hydrochloric acid in 18 hours and then subjected to SPE. The obtained extracts were evaporated to dryness, derivatized with heptafluorobutyric anhydride (HFBA) at 70 °C for 30 minutes prior to GC–MS analysis. Gas chromatography mass spectrometry was run on HP5-MS column (30 m × 0.25 mm × 0.25 µm) with detector MS 5975C. Experimentally, the proposed method proved sensitive, simple and time-saving, but quite accurate with a low limit of detection (LOD = 0.05ng/mg) and quantitation (LOQ = 0.15ng/mg).
 Keywords:
 SPE, GC – MS, hair samples, amphetamine, methamphetamine.
 References
 [1] Ming-Ren Fuh, Ti-Yu Wu and Tzuen-Yeuan Lin, Determination of amphetamine and methamphetamine in urine by solid phase extraction and ion-pair liquid chromatography–electrospray–tandem mass spectrometry Talanta, 68 (3) (2006), 987-991. https://doi.org/10.1016/j.talanta.2005.06.057[2] Naresh C. Jain, Thomas C. Sneath, and Robert D. Budd, Rapid Gas-Chomatographic Determination of Amphetamine and Methamphetamine in urine, Clinical Chemistry, 20 (11) (1974) 1460-1462. https://doi.org/10.1093/clinchem/20.11.1460.[3] Dong-liang Lin, Rea-Ming Yin, Ray H. Liu, Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Amphetamine, Methamphetamine, 3,4-Methylenedioxy- amphetamine and 3,4-Methylenedioxymethamphetamine in Human Hair and Hair Sections, Journal of Food and Drug Analysis, 13(2) (2005) 193-200. https://doi.org/10.38212/2224-6614.2526[4] María Jesús Tabernero, Maria Linda Felli, Ana María Bermejo, Marcello Chiarotti, Determination of ketamine and amphetamines in hair by LC/MS/MS, Anal Bioanal Chem, 395(2009), 2547–2557. https://doi.org/10.1007/s00216-009-3163-4.[5] D.V. Doan, D.Q. Huy, N.D. Hue, T.M. Tri, Determination of methamphetamine in urine samples by gas chromatography mass spectrometry combined with solid phase extraction technique, Journal of Science and Technology 47 (6) (2009) 53-58 (in Vietnamese).[6] Rodger L. Foltz, Allison F. Fentiman, Ruth B. Foltz, GC/MS Assays for Abused Drugs in Body Fluids, National Institute on Drug Abuse, Maryland, 1980.[7] AOAC, Appendix F: Guidelines for Standard Method Performance Requirements, AOAC official methods of analysis, Maryland, 2016.[8] Eunyoung Han, Martin P. Paulus, Marc Wittmann, Heesun Chung, Joon myong Song, Hair analysis and self-report of methamphetamine use by methamphetamine dependent individuals, Journal of Chromatography B, 879 (2011) 541–547. https://doi.org/10.1016/j.jchromb.2011.01.002.