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Journal articles on the topic 'Tick-host interface'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Nuttall, P. A. "Displaced tick-parasite interactions at the host interface." Parasitology 116, S1 (1998): S65—S72. http://dx.doi.org/10.1017/s003118200008495x.

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SummaryReciprocal interactions of parasites transmitted by blood-sucking arthropod vectors have been studied primarily at the parasite–host and parasite–vector interface. The third component of this parasite triangle, the vector–host interface, has been largely ignored. Now there is growing realization that reciprocal interactions between arthropod vectors and their vertebrate hosts play a pivotal role in the survival of arthropod-borne viruses, bacteria, and protozoa. The vector–host interface is the site where the haematophagous arthropod feeds. To obtain a blood meal, the vector must overco

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2

BROSSARD, M., and S. K. WIKEL. "Tick immunobiology." Parasitology 129, S1 (2004): S161—S176. http://dx.doi.org/10.1017/s0031182004004834.

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Ticks are of vast medical and veterinary public health importance due to direct damage caused by feeding and their roles in transmitting well known and emerging infectious agents. Ticks and tick-borne pathogens stimulate the immune system of the host. Those immune interactions are of importance in tick biology, pathogen transmission and control of ticks and tick-borne diseases. Both innate and specific acquired immune defenses are involved in the responses of vertebrate hosts to infestation. Ticks have evolved countermeasures to circumvent host immune defenses. This review addresses the immuno

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Heinze, Dar M., J. Russ Carmical, Judith F. Aronson, and Saravanan Thangamani. "Early Immunologic Events at the Tick-Host Interface." PLoS ONE 7, no. 10 (2012): e47301. http://dx.doi.org/10.1371/journal.pone.0047301.

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NUTTALL, P. A., and M. LABUDA. "Tick–host interactions: saliva-activated transmission." Parasitology 129, S1 (2004): S177—S189. http://dx.doi.org/10.1017/s0031182004005633.

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The skin site at which ticks attach to their hosts to feed is the critical interface between the tick and its host, and tick-borne pathogens. This site is highly modified by the pharmacologically active molecules secreted in tick saliva. For pathogens, it is an ecologically privileged niche that many exploit. Such exploitation is referred to as saliva-activated transmission (SAT) – the indirect promotion of tick-borne pathogen transmission via the actions of bioactive tick saliva molecules on the vertebrate host. Here we review evidence for SAT and consider what are the most likely candidates

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Vechtova, Pavlina, Jarmila Sterbova, Jan Sterba, et al. "A bite so sweet: the glycobiology interface of tick-host-pathogen interactions." Parasites & Vectors 11, no. 1 (2018): 594. https://doi.org/10.1186/s13071-018-3062-7.

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<strong> <b>Abstract</b> </strong>Vector-borne diseases constitute 17% of all infectious diseases in the world; among the blood-feeding arthropods, ticks transmit the highest number of pathogens. Understanding the interactions between the tick vector, the mammalian host and the pathogens circulating between them is the basis for the successful development of vaccines against ticks or the tick-transmitted pathogens as well as for the development of specific treatments against tick-borne infections. A lot of effort has been put into transcriptomic and proteomic analyses; however, the protein-car

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Wang, Luyao, Yishuo Liu, Rui Pang, et al. "The Tick Saliva Peptide HIDfsin2 TLR4-Dependently Inhibits the Tick-Borne Severe Fever with Thrombocytopenia Syndrome Virus in Mouse Macrophages." Antibiotics 13, no. 5 (2024): 449. http://dx.doi.org/10.3390/antibiotics13050449.

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Ticks transmit a variety of pathogens to their hosts by feeding on blood. The interactions and struggle between tick pathogens and hosts have evolved bilaterally. The components of tick saliva can directly or indirectly trigger host biological responses in a manner that promotes pathogen transmission; however, host cells continuously develop strategies to combat pathogen infection and transmission. Moreover, it is still unknown how host cells develop their defense strategies against tick-borne viruses during tick sucking. Here, we found that the tick saliva peptide HIDfsin2 enhanced the antivi

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Jmel, Mohamed Amine, Hajer Aounallah, Chaima Bensaoud, et al. "Insights into the Role of Tick Salivary Protease Inhibitors during Ectoparasite–Host Crosstalk." International Journal of Molecular Sciences 22, no. 2 (2021): 892. http://dx.doi.org/10.3390/ijms22020892.

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Protease inhibitors (PIs) are ubiquitous regulatory proteins present in all kingdoms. They play crucial tasks in controlling biological processes directed by proteases which, if not tightly regulated, can damage the host organism. PIs can be classified according to their targeted proteases or their mechanism of action. The functions of many PIs have now been characterized and are showing clinical relevance for the treatment of human diseases such as arthritis, hepatitis, cancer, AIDS, and cardiovascular diseases, amongst others. Other PIs have potential use in agriculture as insecticides, anti

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López González, Carlos A., Norma Hernández-Camacho, Gabriela Aguilar-Tipacamú, Salvador Zamora-Ledesma, Andrea M. Olvera-Ramírez, and Robert W. Jones. "Gap Analysis of the Habitat Interface of Ticks and Wildlife in Mexico." Pathogens 10, no. 12 (2021): 1541. http://dx.doi.org/10.3390/pathogens10121541.

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Mexico is a highly diverse country where ticks and tick-borne diseases (TBD) directly impact the health of humans and domestic and wild animals. Ticks of the genera Rhipicephalus spp., Amblyomma spp., and Ixodes spp. represent the most important species in terms of host parasitism and geographical distribution in the country, although information on other genera is either limited or null. In addition, information regarding the influence of global warming on the increase in tick populations is scarce or nonexistent, despite climate conditions being the most important factors that determine tick

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Hodzic, Emir, Stefan Tunev, Sunlian Feng, Kim J. Freet, and Stephen W. Barthold. "Immunoglobulin-Regulated Expression of Borrelia burgdorferi Outer Surface Protein A In Vivo." Infection and Immunity 73, no. 6 (2005): 3313–21. http://dx.doi.org/10.1128/iai.73.6.3313-3321.2005.

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ABSTRACT Borrelia burgdorferi, the agent of Lyme disease, down-regulates outer surface protein A (OspA), which is abundantly expressed in ticks, during infection of the mammalian host. In this study we examined the signals that may be responsible for maintaining the OspA-negative state of spirochetes during infection. Transcription of ospA mRNA was found in tissues of C3H-severe combined immunodeficient (C3H-scid) mice, but not immunocompetent C3H mice, inoculated with cultured B. burgdorferi, tick-borne spirochetes, and host-adapted spirochetes. Transcription was more frequent at 4 weeks than

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Oleaga, Ana, Beatriz Soriano, Carlos Llorens, and Ricardo Pérez-Sánchez. "Sialotranscriptomics of the argasid tick Ornithodoros moubata along the trophogonic cycle." PLOS Neglected Tropical Diseases 15, no. 2 (2021): e0009105. http://dx.doi.org/10.1371/journal.pntd.0009105.

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The argasid tick Ornithodoros moubata is the main vector of human relapsing fever (HRF) and African swine fever (ASF) in Africa. Salivary proteins are part of the host-tick interface and play vital roles in the tick feeding process and the host infection by tick-borne pathogens; they represent interesting targets for immune interventions aimed at tick control. The present work describes the transcriptome profile of salivary glands of O. moubata and assesses the gene expression dynamics along the trophogonic cycle using Illumina sequencing. De novo transcriptome assembling resulted in 71,194 tr

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11

Selinger, Martin, Radim Novotný, Jakub Sýs, et al. "Tick-borne encephalitis virus capsid protein induces translational shutoff as revealed by its structural–biological analysis." Journal of Biological Chemistry 298, no. 11 (2022): 102585. https://doi.org/10.1016/j.jbc.2022.102585.

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Tick-borne encephalitis virus (TBEV) is the most medically relevant tick-transmitted Flavivirus in Eurasia, targeting the host central nervous system and frequently causing severe encephalitis. The primary function of its capsid protein (TBEVC) is to recruit the viral RNA and form a nucleocapsid. Additional functionality of Flavivirus capsid proteins has been documented, but further investigation is needed for TBEVC. Here, we show the first capsid protein 3D structure of a member of the tick-borne flaviviruses group. The structure of monomeric Δ16-TBEVC was determined using high-resoluti

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Hermance, Meghan, and Saravanan Thangamani. "Tick–Virus–Host Interactions at the Cutaneous Interface: The Nidus of Flavivirus Transmission." Viruses 10, no. 7 (2018): 362. http://dx.doi.org/10.3390/v10070362.

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OGDEN, N. H., A. N. J. CASEY, N. P. FRENCH, K. J. BOWN, J. D. W. ADAMS, and Z. WOLDEHIWET. "Natural Ehrlichia phagocytophila transmission coefficients from sheep ‘carriers’ to Ixodes ricinus ticks vary with the numbers of feeding ticks." Parasitology 124, no. 2 (2002): 127–36. http://dx.doi.org/10.1017/s003118200100107x.

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In a longitudinal study in a UK upland site, 38% of adult sheep were detected as infected with the tick-borne bacterium Ehrlichia phagocytophila by PCR of blood samples. Infection prevalence declined significantly with sheep age but varied significantly and non-linearly with the number of adult Ixodes ricinus ticks feeding per sheep. These findings suggested that under conditions of natural repeated tick-borne challenge sheep remain partially susceptible to re-infections, but the likelihood of re-infection depended on the numbers of feeding ticks. Transmission efficiency from sheep to immature

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FUKUNAGA, Masahito, and Norihiko TABUCHI. "Molecular mechanism of the borrelial proteins at interface with host and vector tick interactions." Nippon Saikingaku Zasshi 65, no. 3 (2010): 343–53. http://dx.doi.org/10.3412/jsb.65.343.

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15

Solyman, Muna Salem M., Jessica Ujczo, Kelly A. Brayton, Dana K. Shaw, David A. Schneider, and Susan M. Noh. "Iron Reduction in Dermacentor andersoni Tick Cells Inhibits Anaplasma marginale Replication." International Journal of Molecular Sciences 23, no. 7 (2022): 3941. http://dx.doi.org/10.3390/ijms23073941.

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Anaplasma spp. are obligate intracellular, tick-borne, bacterial pathogens that cause bovine and human anaplasmosis. We lack tools to prevent these diseases in part due to major knowledge gaps in our fundamental understanding of the tick–pathogen interface, including the requirement for and molecules involved in iron transport during tick colonization. We determine that iron is required for the pathogen Anaplasma marginale, which causes bovine anaplasmosis, to replicate in Dermacentor andersoni tick cells. Using bioinformatics and protein modeling, we identified three orthologs of the Gram-neg

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Schmidtmann, E. T., J. F. Carroll, and W. J. E. Potts. "Host-Seeking of Blaeklegged Tick (Acari: Ixodidae) Nymphs and Adults at the Woods—Pasture Interface." Journal of Medical Entomology 31, no. 2 (1994): 291–96. http://dx.doi.org/10.1093/jmedent/31.2.291.

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MITREA, Emanuel, Andreea Monica BOGDAN, Anca Maria ZISOPOL, Ioan Liviu MITREA, and Mariana IONIȚĂ. "PRELIMINARY DATA ON MOLECULAR TESTING FOR ANAPLASMA PHAGOCYTOPHILUM INFECTION IN CATTLE AND HORSES, ROMANIA." Scientific Papers Journal VETERINARY SERIES 67, no. 1 (2024): 24–29. https://doi.org/10.61900/spjvs.2024.01.04.

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Ticks are among the most important group of vectors for pathogens causing vector-borne diseases in Europe. Over the last two decades, numerous reports strongly emphasize on the spreading and increased abundance of ticks in Romania. Moreover, molecular reports have also documented on the diverse tick-borne pathogens circulating at the domestic and wild host-tick interface. Among them, (re)-emerging tick-borne pathogens, including causative agents of zoonotic diseases, with high impact on the animal and human health are reported. Anaplasma phagocytophilum, the causative agent of granulocytic ana

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Zaheer, Tean, Mahmoud Kandeel, Rao Zahid Abbas, Shanza Rauf Khan, Tauseef ur Rehman, and Amjad Islam Aqib. "Acaricidal Potential and Ecotoxicity of Metallic Nano-Pesticides Used against the Major Life Stages of Hyalomma Ticks." Life 12, no. 7 (2022): 977. http://dx.doi.org/10.3390/life12070977.

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Ticks (Acari: Ixodidae) are blood-feeding parasites capable of transmitting diseases to animals (Piroplasmosis) and humans (Congo fever, Lyme disease). The non-judicious use of chemical acaricides has led to the development of acaricide-resistant ticks, making the control of ticks and tick-borne diseases difficult. This study reports the efficacy of magnesium oxide (MgO), iron oxide (Fe2O3), and zinc oxide (ZnO) nanoparticles (NPs) as alternatives to traditional acaricides/pesticides using in vitro tests against major representative stages of Hyalomma ticks. Nanopesticides were chemically synt

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Bastos, Reginaldo G., Jose Thekkiniath, Choukri Ben Mamoun, et al. "Babesia microti Immunoreactive Rhoptry-Associated Protein-1 Paralogs Are Ancestral Members of the Piroplasmid-Confined RAP-1 Family." Pathogens 10, no. 11 (2021): 1384. http://dx.doi.org/10.3390/pathogens10111384.

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Babesia, Cytauxzoon and Theileria are tick-borne apicomplexan parasites of the order Piroplasmida, responsible for diseases in humans and animals. Members of the piroplasmid rhoptry-associated protein-1 (pRAP-1) family have a signature cysteine-rich domain and are important for parasite development. We propose that the closely linked B. microti genes annotated as BMR1_03g00947 and BMR1_03g00960 encode two paralogue pRAP-1-like proteins named BmIPA48 and Bm960. The two genes are tandemly arranged head to tail, highly expressed in blood stage parasites, syntenic to rap-1 genes of other piroplasm

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Caldwell, Marissa, Abhilasha P. Boruah, and Kiran T. Thakur. "Acute neurologic emerging flaviviruses." Therapeutic Advances in Infectious Disease 9 (January 2022): 204993612211026. http://dx.doi.org/10.1177/20499361221102664.

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The COVID-19 pandemic has shed light on the challenges we face as a global society in preventing and containing emerging and re-emerging pathogens. Multiple intersecting factors, including environmental changes, host immunological factors, and pathogen dynamics, are intimately connected to the emergence and re-emergence of communicable diseases. There is a large and expanding list of communicable diseases that can cause neurological damage, either through direct or indirect routes. Novel pathogens of neurotropic potential have been identified through advanced diagnostic techniques, including m

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21

Antonara, Styliani, Laura Ristow, James McCarthy, and Jenifer Coburn. "Effect of Borrelia burgdorferi OspC at the Site of Inoculation in Mouse Skin." Infection and Immunity 78, no. 11 (2010): 4723–33. http://dx.doi.org/10.1128/iai.00464-10.

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ABSTRACT The Borrelia burgdorferi surface lipoprotein OspC is a critical virulence factor, but its precise role in the establishment of B. burgdorferi infection remains unclear. To determine whether OspC affects the host response at the site of inoculation of the bacterium, the recruitment of macrophages and neutrophils and the production of cytokines were examined at the site of infection by wild-type, ospC mutant, and complemented mutant B. burgdorferi strains. Of the 21 cytokines tested, monocyte chemoattractant protein 1 (MCP-1), keratinocyte-derived chemokine (KC, CXCL1), and vascular end

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Hodzic, Emir, Sunlian Feng, Kimberly J. Freet, Dori L. Borjesson, and Stephen W. Barthold. "Borrelia burgdorferi Population Kinetics and Selected Gene Expression at the Host-Vector Interface." Infection and Immunity 70, no. 7 (2002): 3382–88. http://dx.doi.org/10.1128/iai.70.7.3382-3388.2002.

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ABSTRACT By using real-time quantitative PCR, the population dynamics and gene transcription of Borrelia burgdorferi were examined in ticks and skin of mice during acquisition of the infection from mice by ticks and during transmission of the infection from ticks to mice. Population dynamics were determined by using a flaB DNA target. A quantitative analysis of flaB, ospA, ospC, dbpA, and arp transcription was also performed. The results revealed that both uninfected larval and nymphal Ixodes scapularis ticks acquired B. burgdorferi as early as 1 day after attachment and that the sizes of spir

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Ali, Abid, Ismail Zeb, Abdulaziz Alouffi, et al. "Host Immune Responses to Salivary Components - A Critical Facet of Tick-Host Interactions." Frontiers in Cellular and Infection Microbiology 12 (March 16, 2022). http://dx.doi.org/10.3389/fcimb.2022.809052.

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Tick sialome is comprised of a rich cocktail of bioactive molecules that function as a tool to disarm host immunity, assist blood-feeding, and play a vibrant role in pathogen transmission. The adaptation of the tick’s blood-feeding behavior has lead to the evolution of bioactive molecules in its saliva to assist them to overwhelm hosts’ defense mechanisms. During a blood meal, a tick secretes different salivary molecules including vasodilators, platelet aggregation inhibitors, anticoagulants, anti-inflammatory proteins, and inhibitors of complement activation; the salivary repertoire changes t

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Abbas, Muhammad Nadeem, Adéla Chlastáková, Mohamed Amine Jmel, Evangelia Iliaki-Giannakoudaki, Jindřich Chmelař, and Michail Kotsyfakis. "Serpins in Tick Physiology and Tick-Host Interaction." Frontiers in Cellular and Infection Microbiology 12 (May 19, 2022). http://dx.doi.org/10.3389/fcimb.2022.892770.

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Tick saliva has been extensively studied in the context of tick-host interactions because it is involved in host homeostasis modulation and microbial pathogen transmission to the host. Accumulated knowledge about the tick saliva composition at the molecular level has revealed that serine protease inhibitors play a key role in the tick-host interaction. Serpins are one highly expressed group of protease inhibitors in tick salivary glands, their expression can be induced during tick blood-feeding, and they have many biological functions at the tick-host interface. Indeed, tick serpins have an im

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Chaima, ben BENSAOUD. "Quantitative proteomics analysis reveals core and variable tick salivary proteins at the tick-vertebrate host interface." March 30, 2022. https://doi.org/10.5281/zenodo.6396546.

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Few studies have examined tick proteomes, how they adapt to their environment, and their roles in the parasite-host interactions that drive tick infestation and pathogen transmission. Here we used a proteomics approach to screen for biologically and immunologically relevant proteins acting at the tick-host interface during tick feeding and, as proof of principle, measured host antibody responses to some of the discovered candidates. We used a label-free quantitative proteomic workflow to study salivary proteomes of (i) wild <em>Ixodes ricinus</em> ticks fed on different hosts; (ii) wild or lab

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Kazimírová, Mária, Saravanan Thangamani, Pavlína Bartíková, et al. "Tick-Borne Viruses and Biological Processes at the Tick-Host-Virus Interface." Frontiers in Cellular and Infection Microbiology 7 (July 26, 2017). http://dx.doi.org/10.3389/fcimb.2017.00339.

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Wikel, Stephen K., and Rangappa N. Ramachandra. "Immunology of the Host-Vector-Pathogen Interface." American Association of Bovine Practitioners Conference Proceedings, August 21, 1992, 34–43. http://dx.doi.org/10.21423/aabppro19926413.

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Hematophagous arthropods and the diseases they transmit are of vast medical and veterinary public health importance. Ticks are the most important vectors of pathogens to domestic and wild animal species, and they are second only to mosquitoes as transmitters of disease causing agents to humans.1 The patterns, number and variety of tick-borne diseases continues to change.2 It is likely that this trend will continue into the future. This review will focus upon tick-host-pathogen interactions, due to the body of information available related to these associations.

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Bastard, Jonathan, Nichar Gregory, Pilar Fernandez, et al. "Cascading effects of mammal host community composition on tick vector occurrence at the urban human–wildlife interface." Ecosphere 15, no. 8 (2024). http://dx.doi.org/10.1002/ecs2.4957.

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AbstractHabitat fragmentation and host community composition are implicated as key drivers of changing tick populations and tick‐borne pathogen dynamics, altering infection risk through coupled socioecological pathways that mediate interactions between tick vectors, vertebrate hosts, and humans. Patterns of host diversity may be particularly idiosyncratic across urbanized landscapes, due to trade‐offs between extreme fragmentation that reduces habitat suitability and access, and human activities that artificially increase resource availability for wildlife. We used camera and hair trap surveys

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Kleissl, Lisa, Sophie Weninger, Florian Winkler, Margarida Ruivo, Michiel Wijnveld, and Johanna Strobl. "Ticks’ tricks: immunomodulatory effects of ixodid tick saliva at the cutaneous tick-host interface." Frontiers in Immunology 16 (March 27, 2025). https://doi.org/10.3389/fimmu.2025.1520665.

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Due to changes in global climate, the geographic distribution of ticks and tick-borne infections is increasing and represents a growing global health concern for humans. Ticks of the genus Ixodidae are globally abundant and transmit a wide variety of pathogens that cause human infections, including tick-borne encephalitis and Lyme borreliosis. The transmission of pathogens into human skin while blood feeding causes changes in the local immune cell network and has various effects on structural skin cells, including sensory neurons. Recent studies have focused on the effect of tick saliva on cel

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Cao, Yongguo, Connor Rosen, Gunjan Arora, et al. "An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector." Infection and Immunity 88, no. 12 (2020). http://dx.doi.org/10.1128/iai.00426-20.

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ABSTRACT Borrelia burgdorferi causes Lyme disease, the most common tick-transmitted illness in North America. When Ixodes scapularis feed on an infected vertebrate host, spirochetes enter the tick gut along with the bloodmeal and colonize the vector. Here, we show that a secreted tick protein, I. scapularis protein disulfide isomerase A3 (IsPDIA3), enhances B. burgdorferi colonization of the tick gut. I. scapularis ticks in which ispdiA3 has been knocked down using RNA interference have decreased spirochete colonization of the tick gut after engorging on B. burgdorferi-infected mice. Moreover,

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Zhang, Xue, and Jianhong Wu. "A coupled algebraic-delay differential system modeling tick-host interactive behavioural dynamics and multi-stability." Journal of Mathematical Biology 86, no. 3 (2023). http://dx.doi.org/10.1007/s00285-023-01879-8.

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AbstractWe propose a coupled system of delay-algebraic equations to describe tick attaching and host grooming behaviors in the tick-host interface, and use the model to understand how this tick-host interaction impacts the tick population dynamics. We consider two critical state variables, the loads of feeding ticks on host and the engorged ticks on the ground for ticks in a particular development stage (nymphal stage) and show that the model as a coupled system of delay differential equation and an algebraic (integral) equation may have rich structures of equilibrium states, leading to multi-

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de la Fuente, José, Sara Artigas-Jerónimo, and Margarita Villar. "Akirin/Subolesin regulatory mechanisms at host/tick–pathogen interactions." microLife 3 (November 11, 2021). http://dx.doi.org/10.1093/femsml/uqab012.

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ABSTRACT Ticks and tick-borne pathogens such as Anaplasma phagocytophilum affect human and animal health worldwide and thus the characterization of host/tick–pathogen interactions is important for the control of tick-borne diseases. The vertebrate regulatory proteins Akirins and its tick ortholog, Subolesin, are conserved throughout the metazoan and involved in the regulation of different biological processes such as immune response to pathogen infection. Akirin/Subolesin have a key role in host/tick–pathogen interactions and exert its regulatory function primarily through interacting proteins

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Tabor, Ala E., Abid Ali, Gauhar Rehman, et al. "Cattle Tick Rhipicephalus microplus-Host Interface: A Review of Resistant and Susceptible Host Responses." Frontiers in Cellular and Infection Microbiology 7 (December 11, 2017). http://dx.doi.org/10.3389/fcimb.2017.00506.

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Neelakanta, Girish, and Hameeda Sultana. "Tick Saliva and Salivary Glands: What Do We Know So Far on Their Role in Arthropod Blood Feeding and Pathogen Transmission." Frontiers in Cellular and Infection Microbiology 11 (January 19, 2022). http://dx.doi.org/10.3389/fcimb.2021.816547.

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Ticks are blood-sucking arthropods that have developed myriad of strategies to get a blood meal from the vertebrate host. They first attach to the host skin, select a bite site for a blood meal, create a feeding niche at the bite site, secrete plethora of molecules in its saliva and then starts feeding. On the other side, host defenses will try to counter-attack and stop tick feeding at the bite site. In this constant battle between ticks and the host, arthropods successfully pacify the host and completes a blood meal and then replete after full engorgement. In this review, we discuss some of

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Maqbool, Mahvish, Muhammad Sohail Sajid, Muhammad Saqib, et al. "Potential Mechanisms of Transmission of Tick-Borne Viruses at the Virus-Tick Interface." Frontiers in Microbiology 13 (May 5, 2022). http://dx.doi.org/10.3389/fmicb.2022.846884.

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Ticks (Acari; Ixodidae) are the second most important vector for transmission of pathogens to humans, livestock, and wildlife. Ticks as vectors for viruses have been reported many times over the last 100 years. Tick-borne viruses (TBVs) belong to two orders (Bunyavirales and Mononegavirales) containing nine families (Bunyaviridae, Rhabdoviridae, Asfarviridae, Orthomyxovirida, Reoviridae, Flaviviridae, Phenuviridae, Nyamiviridae, and Nairoviridae). Among these TBVs, some are very pathogenic, causing huge mortality, and hence, deserve to be covered under the umbrella of one health. About 38 vira

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Boulanger, Nathalie, Jean-Louis-Marie Insonere, Sebastian Van Blerk, et al. "Cross-alteration of murine skin and tick microbiome concomitant with pathogen transmission after Ixodes ricinus bite." Microbiome 11, no. 1 (2023). http://dx.doi.org/10.1186/s40168-023-01696-7.

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Abstract Background Ticks are major vectors of diseases affecting humans such as Lyme disease or domestic animals such as anaplasmosis. Cross-alteration of the vertebrate host skin microbiome and the tick microbiome may be essential during the process of tick feeding and for the mechanism of pathogen transmission. However, it has been poorly investigated. Methods We used mice bitten by field-collected ticks (nymphs and adult ticks) in different experimental conditions to investigate, by 16S rRNA gene metabarcoding, the impact of blood feeding on both the mouse skin microbiome and the tick micr

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Valdés, James J. "Antihistamine response: a dynamically refined function at the host-tick interface." Parasites & Vectors 7, no. 1 (2014). http://dx.doi.org/10.1186/s13071-014-0491-9.

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38

Bensaoud, Chaima, Stefan Tenzer, Alicia Poplawski, et al. "Quantitative proteomics analysis reveals core and variable tick salivary proteins at the tick‐vertebrate host interface." Molecular Ecology, June 4, 2022. http://dx.doi.org/10.1111/mec.16561.

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Makwatta, JohnMark O., Paul N. Ndegwa, Florence A. Oyieke, Peter Ahuya, Daniel K. Masiga, and Merid N. Getahun. "Exploring the dynamic adult hard ticks-camel-pathogens interaction." mSphere, October 29, 2024. http://dx.doi.org/10.1128/msphere.00405-24.

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ABSTRACT The ability of ticks to interact and adapt to different ecologies and hosts determines their vectorial competence for various pathogens; however, ticks-livestock-pathogens interaction studies are limited. With our ticks-hosts-pathogens interface studies, we found 14 species of hard ticks feeding on various livestock. Ticks showed a strong preference for one-humped camels ( Camelus dromedarius ). The camel nostril was the most preferred predilection site. The most prevalent tick species on camels was Hyalomma rufipes . We found two novel Amblyomma gemma variants which are distinct both

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Cano, Argüelles Ana Laura, Ricardo Pérez-Sánchez, and ANA OLEAGA. "A microRNA profile of the saliva in the argasid ticks Ornithodoros erraticus and Ornithodoros moubata and prediction of specific target genes." September 8, 2023. https://doi.org/10.1016/j.ttbdis.2023.102249.

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Ornithodoros erraticus and Ornithodoros moubata ticks are the main vectors of the agents of human relapsing fever (TBRF) and African swine fever (ASF) in the Mediterranean Basin and Africa, respectively. Tick saliva is crucial for complete tick feeding and pathogen transmission, as it contains numerous molecules such as proteins, lipids, and non-coding RNAs (ncRNA) including microRNAs (miRNA). MiRNAs are small ncRNAs capable of regulating the expression of their target messenger RNA (mRNA) leading to degradation or inhibition of its translation into protein. Research on miRNAs from ixodid tick

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Thangamani, Saravanan, Meghan E. Hermance, Rodrigo I. Santos, et al. "Transcriptional Immunoprofiling at the Tick-Virus-Host Interface during Early Stages of Tick-Borne Encephalitis Virus Transmission." Frontiers in Cellular and Infection Microbiology 7 (December 1, 2017). http://dx.doi.org/10.3389/fcimb.2017.00494.

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Jin, Lin, Bao-Gui Jiang, Yizhu Yin та ін. "Interference with LTβR signaling by tick saliva facilitates transmission of Lyme disease spirochetes". Proceedings of the National Academy of Sciences 119, № 47 (2022). http://dx.doi.org/10.1073/pnas.2208274119.

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Lyme spirochetes have coevolved with ticks to optimize transmission to hosts using tick salivary molecules (TSMs) to counteract host defenses. TSMs modulate various molecular events at the tick–host interface. Lymphotoxin-beta receptor (LTβR) is a vital immune receptor and plays protective roles in host immunity against microbial infections. We found that Ltbr knockout mice were more susceptible to Lyme disease spirochetes, suggesting the involvement of LTβR signaling in tick-borne Borrelia infection. Further investigation showed that a 15-kDa TSM protein from Ixodes persulcatus ( I. persulcat

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Scott, Alison J., Alexis A. Smith, Ron M. A. Heeren, Utpal Pal, and Robert K. Ernst. "Characterization of spatial lipidomic signatures in tick-bitten guinea pig skin as a model for host-vector-pathogen interaction profiling." mSystems, October 24, 2023. http://dx.doi.org/10.1128/msystems.00927-23.

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ABSTRACT Spatially aware de novo discovery methods are essential tools for therapeutic target identification in complex interphylum interactions such as arthropods and mammals. Notably, the methods should ideally be species agnostic, showing unique features of all interacting species. We evaluated the possibilities for matrix-assisted desorption/ionization mass spectrometry imaging (MALDI-MSI, referred to here as MSI) as a spatial “omics” method to simultaneously profile both an arthropod vector ( Ixodes tick) and a mammalian skin (guinea pig) in a bite model. We demonstrated the feasibility o

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Vechtova, Pavlina, Jarmila Sterbova, Jan Sterba, et al. "A bite so sweet: the glycobiology interface of tick-host-pathogen interactions." Parasites & Vectors 11, no. 1 (2018). http://dx.doi.org/10.1186/s13071-018-3062-7.

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Oleaga, Ana, Angel Carnero-Morán, M. Luz Valero, and Ricardo Pérez-Sánchez. "Proteomics informed by transcriptomics for a qualitative and quantitative analysis of the sialoproteome of adult Ornithodoros moubata ticks." Parasites & Vectors 14, no. 1 (2021). http://dx.doi.org/10.1186/s13071-021-04892-2.

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Abstract Background The argasid tick Ornithodoros moubata is the main vector in mainland Africa of African swine fever virus and the spirochete Borrelia duttoni, which causes human relapsing fever. The elimination of populations of O. moubata would contribute to the prevention and control of these two serious diseases. Anti-tick vaccines are an eco-friendly and sustainable means of eliminating tick populations. Tick saliva forms part of the tick-host interface, and knowledge of its composition is key to the identification and selection of vaccine candidate antigens. The aim of the present work

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Pérez-Sánchez, Ricardo, Ángel Carnero-Morán, Beatriz Soriano, Carlos Llorens, and Ana Oleaga. "RNA-seq analysis and gene expression dynamics in the salivary glands of the argasid tick Ornithodoros erraticus along the trophogonic cycle." Parasites & Vectors 14, no. 1 (2021). http://dx.doi.org/10.1186/s13071-021-04671-z.

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Abstract Background The argasid tick Ornithodoros erraticus is the main vector of tick-borne human relapsing fever (TBRF) and African swine fever (ASF) in the Mediterranean Basin. Tick salivary proteins secreted to the host at the feeding interface play critical roles for tick feeding and may contribute to host infection by tick-borne pathogens; accordingly, these proteins represent interesting antigen targets for the development of vaccines aimed at the control and prevention of tick infestations and tick-borne diseases. Methods To identify these proteins, the transcriptome of the salivary gl

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Filatov, Serhii, Filip Dyčka, Jan Sterba, and Ryan O. M. Rego. "A simple non-invasive method to collect soft tick saliva reveals differences in Ornithodoros moubata saliva composition between ticks infected and uninfected with Borrelia duttonii spirochetes." Frontiers in Cellular and Infection Microbiology 13 (January 20, 2023). http://dx.doi.org/10.3389/fcimb.2023.1112952.

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Introduction: We developed a new simple method to assess the composition of proteinaceous components in the saliva of Ornithodoros moubata, the main vehicle for pathogen transmission and a likely source of bioactive molecules acting at the tick-vertebrate host interface. To collect naturally expectorated saliva from the ticks we employed an artificial membrane feeding technique using a simple, chemically defined diet containing phagostimulants and submitted native saliva samples collected in this way for liquid chromatography-mass spectrometry (LC-MS) analysis. These experiments were conducted

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VanAcker, Meredith C., Vickie L. DeNicola, Anthony J. DeNicola, et al. "Resource selection by New York City deer reveals the effective interface between wildlife, zoonotic hazards and humans." Ecology Letters, October 26, 2023. http://dx.doi.org/10.1111/ele.14326.

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AbstractAlthough the role of host movement in shaping infectious disease dynamics is widely acknowledged, methodological separation between animal movement and disease ecology has prevented researchers from leveraging empirical insights from movement data to advance landscape scale understanding of infectious disease risk. To address this knowledge gap, we examine how movement behaviour and resource utilization by white‐tailed deer (Odocoileus virginianus) determines blacklegged tick (Ixodes scapularis) distribution, which depend on deer for dispersal in a highly fragmented New York City borou

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Babayani, Nlingisisi D., and Anastacia Makati. "Predictive Analytics of Cattle Host and Environmental and Micro-Climate Factors for Tick Distribution and Abundance at the Livestock–Wildlife Interface in the Lower Okavango Delta of Botswana." Frontiers in Veterinary Science 8 (October 28, 2021). http://dx.doi.org/10.3389/fvets.2021.698395.

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Tick distribution and abundance is influenced by several factors that include micro-climate and environmental and host factors. Contextual understanding of the role played by these factors is critical to guide control measures. The aim of this study was to determine the predictive value of these factors for changes in tick distribution and abundance at the livestock–wildlife interface of the lower Okavango Delta. A two-stage quota sampling design was adopted to select 30 clusters of seven cattle each for tick investigation. Tick investigation was done by lifting the tail to count the total num

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MacDonald, Andrew, Sofie McComb, and Samantha Sambado. "Linking Lyme disease ecology and epidemiology: reservoir host identity, not richness, determines tick infection and human disease in California." Environmental Research Letters, October 31, 2022. http://dx.doi.org/10.1088/1748-9326/ac9ece.

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Abstract Understanding the community ecology of vector-borne and zoonotic diseases, and how it may shift transmission risk as it responds to environmental change, has become a central focus in disease ecology. Yet, it has been challenging to link the ecology of disease with reported human incidence. Here, we bridge the gap between local-scale community ecology and large-scale disease epidemiology, drawing from a priori knowledge of tick-pathogen-host ecology to model spatially-explicit Lyme disease risk, and human Lyme disease incidence in California. We first use a species distribution modeli

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