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Journal articles on the topic 'Tier-0'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Oitavem, Isabel. "CharacterizingNC with tier 0 pointers." MLQ 50, no. 1 (2004): 9–17. http://dx.doi.org/10.1002/malq.200310070.

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Shepherd, R. K. "Three-tier open nucleus breeding schemes." Animal Science 65, no. 3 (1997): 321–34. http://dx.doi.org/10.1017/s1357729800008523.

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AbstractOptimum designs of three-tier open nucleus breeding schemes are evaluated deterministically by maximizing the equilibrium rate of genetic gain for two methods of selection. Methodology is developed for both restricted and unrestricted migration between tiers and incorporates the loss of variance due to selection. A formula is derived for calculating the asymptotic rate of inbreeding. In the extensive livestock industries, proportional improvements in the equilibrium rate of genetic gain of between 0·12 and 0·22 are possible over a closed nucleus if no restrictions are imposed on male a

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Jones, B., G. McCance, C. Cordeiro, D. Giordano, S. Traylen, and D. Moreno García. "Future Approach to tier-0 extension." Journal of Physics: Conference Series 898 (October 2017): 082040. http://dx.doi.org/10.1088/1742-6596/898/8/082040.

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Oh, Jong Hyeok, and Yun Seop Yu. "Electrical Coupling for Monolithic 3-D Integrated Circuit Consisting of Feedback Field-Effect Transistors." Journal of Nanoscience and Nanotechnology 21, no. 8 (2021): 4293–97. http://dx.doi.org/10.1166/jnn.2021.19387.

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In this study, for two cases of monolithic 3-dimensional integrated circuit (M3DIC) consisting of vertically stacked feedback field-effect transistors (FBFETs), the variation of electrical characteristics of the FBFET was presented in terms of electrical coupling by using technology computer aided design (TCAD) simulation. In the Case 1, the M3DIC was composed with an N-type FBFET in an upper tier (tier2) and a P-type FBFET in a lower tier (tier1), and in the Case 2, it was composed with the FBFETs of opposite type of the Case 1 on each tier. To utilize the FBFET as a logic device, the study o

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Hufnagel, Dirk. "CMS Tier-0: Preparing for the future." Journal of Physics: Conference Series 396, no. 2 (2012): 022025. http://dx.doi.org/10.1088/1742-6596/396/2/022025.

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Elsing, Markus, Luc Goossens, Armin Nairz, and Guido Negri. "The ATLAS Tier-0: Overview and operational experience." Journal of Physics: Conference Series 219, no. 7 (2010): 072011. http://dx.doi.org/10.1088/1742-6596/219/7/072011.

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Thavaneswaran, Subotheni, Mandy L. Ballinger, John Grady, et al. "The Cancer Molecular Screening and Therapeutics Program (MoST): Actionable mutation frequencies in a population with rare and less common cancers." Journal of Clinical Oncology 37, no. 15_suppl (2019): 3136. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3136.

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3136 Background: Personalizing therapy will arguably have no greater impact than on patients (pts) with rare (< 6 per 100,000 population) or less common cancers (6-12/100,000). MoST combines a molecular screening platform and biomarker-driven treatments for pts with advanced cancer, with a particular focus on rare and less common cancers (RLC). Methods: Molecular screening was performed using in-house and commercial panels on archival tumor tissue. A Molecular Tumor Board by consensus reported on pathogenic variants with potential therapeutic actionability. Tiers of actionability were defin

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Rabuya, Isabelo, Melissa Libres, Michael Lochinvar Abundo, and Evelyn Taboada. "Moving Up the Electrification Ladder in Off-Grid Settlements with Rooftop Solar Microgrids." Energies 14, no. 12 (2021): 3467. http://dx.doi.org/10.3390/en14123467.

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The multi-tier framework (MTF) of electricity access defines a continuum of electrification from tier 0, where access is inexistent or very limited, to tier 5 where access is of grid quality. Transitioning households from lower to higher tiers unlocks the potential in meeting more of their energy needs. This study investigates the transition towards higher tier electricity access on Gilutongan Island, an off-grid island of Cebu, Philippines, which is also an informal settlement community with no open land available for a centralized solar PV system. The solar PV potential of suitable rooftops

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Hufnagel, Dirk. "The architecture and operation of the CMS Tier-0." Journal of Physics: Conference Series 331, no. 3 (2011): 032017. http://dx.doi.org/10.1088/1742-6596/331/3/032017.

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Qudratuddarsi, Hilman, Nurhikma Ramadhana, Nor Indriyanti, and Ayu Indayanti Ismail. "Using Item Option Characteristics Curve (IOCC) to Unfold Misconception on Chemical Reaction." Journal of Tropical Chemistry Research and Education 6, no. 2 (2024): 105–18. https://doi.org/10.14421/jtcre.2024.62-04.

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Misconceptions can significantly hinder the learning process. To address this, various diagnostic instruments such as two-tier (2TMC), three-tier, and four-tier multiple-choice questions have been introduced. However, as the number of tiers increases, identifying misconceptions becomes more complex. Therefore, this study employs the Item Option Characteristics Curve (IOCC) to identify misconceptions by calculating the probability of each option being selected. The Representational Systems and Chemical Reactions Diagnostic Instrument (RSCRDI) was administered to 185 pre-service teachers across

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Nwe, Khine, Mark Erik Larsen, Natalie Nelissen, and David Chi-Wai Wong. "Medical Mobile App Classification Using the National Institute for Health and Care Excellence Evidence Standards Framework for Digital Health Technologies: Interrater Reliability Study." Journal of Medical Internet Research 22, no. 6 (2020): e17457. http://dx.doi.org/10.2196/17457.

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Background Clinical governance of medical mobile apps is challenging, and there is currently no standard method for assessing the quality of such apps. In 2018, the National Institute for Health and Care Excellence (NICE) developed a framework for assessing the required level of evidence for digital health technologies (DHTs), as determined by their clinical function. The framework can potentially be used to assess mobile apps, which are a subset of DHTs. To be used reliably in this context, the framework must allow unambiguous classification of an app’s clinical function. Objective The object

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Bärring, Olof. "Preparing CERN Tier-0 data centres for LHC Run 3." EPJ Web of Conferences 245 (2020): 07057. http://dx.doi.org/10.1051/epjconf/202024507057.

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Since 2013 CERN’s local data centre combined with a colocation infrastructure at the Wigner data centre in Budapest [1] have been hosting the compute and storage capacity for Worldwide LHC Computing Grid (WLCG) [2] Tier-0. In this paper we will describe how we try to optimize and improve the operation of our local data centre to meet the anticipated increment of the physics compute and storage requirements for Run 3, taking into account two important changes on the way: the end of the co-location contract with Wigner in 2019 and the loan of 2 out of 6 prefabricated compute modules being commis

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Amado, Jhonatan, Jan Eysermans, German Giraldo, Dirk Hufnagel, Dmytro Kovalskyi, and Antonio Linares Sancho. "CMS Tier-0 data processing during the detector commissioning in Run 3." EPJ Web of Conferences 295 (2024): 03007. http://dx.doi.org/10.1051/epjconf/202429503007.

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The CMS Tier-0 system is responsible for the prompt processing and distribution of the data collected by the CMS Experiment. A number of upgrades were implemented during the long shutdown 2 of the Large Hadron Collider, which improved the performance and reliability of the system. In this report, these upgrades are discussed and a more detailed description of the Tier-0 system is given. The experience of the data taking during Run 3 detector commissioning as well as the performance of the system are highlighted.

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Chao, Yin-Kai, and Hsin-Yueh Fang. "PS02.085: ASSESSMENT OF TUMOR REGRESSION OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA AFTER NEOADJUVANT CHEMORADIOTHERAPY: COMPARISON OF 3 COMMONLY USED SCORING APPROACHES." Diseases of the Esophagus 31, Supplement_1 (2018): 144–45. http://dx.doi.org/10.1093/dote/doy089.ps02.085.

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Abstract Background Tumor regression grade (TRG) is a measure of histopathological response of cancer to neoadjuvant chemoradiotherapy(nCRT) and is associated with outcomes. Several TRG system are used in esophageal cancer: Schneider 4 tier(0%,1∼10%,10∼50%, > 50% vital residual tumor cell[VRTC]), Chirieac 3 tier(0%,1∼50%, > 50% VRTC) and Japanese 4 tier(0%,1∼33%,33∼66%, > 66% VRTC). Although these methods are generally accepted, currently there is no common standard. Methods We compared the application of three major systems for assessment of tumor regression. Hematoxylin and eosin–st

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Bauman, Julie E., Umamaheswar Duvvuri, Robert L. Ferris, et al. "Phase I study of the anti-HGF monoclonal antibody (mAb), ficlatuzumab, and cetuximab in cetuximab-resistant, recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 6038. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.6038.

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6038 Background: Cetuximab, an anti-EGFR mAb, is approved for R/M HNSCC but only a minority benefits. Activation of cMet, the receptor for hepatocyte growth factor (HGF), overcomes EGFR inhibition in preclinical models and high serum HGF is associated with resistance in patients (pts). We conducted a phase I trial evaluating the combination of cetuximab and ficlatuzumab, an IgG1 anti-HGF mAb, in pts with cetuximab-resistant, R/M HNSCC. Methods: In this Narayana k-in-a-row phase I design, cetuximab 500 mg/m2 was administered every 2 weeks. Ficlatuzumab dose tiers were 10 mg/kg (tier 1) or 20 mg

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Hassler, Birgit, Stefanie Kremser, Greg E. Bodeker, et al. "An updated version of a gap-free monthly mean zonal mean ozone database." Earth System Science Data 10, no. 3 (2018): 1473–90. http://dx.doi.org/10.5194/essd-10-1473-2018.

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Abstract. An updated and improved version of a global, vertically resolved, monthly mean zonal mean ozone database has been calculated – hereafter referred to as the BSVertOzone (Bodeker Scientific Vertical Ozone) database. Like its predecessor, it combines measurements from several satellite-based instruments and ozone profile measurements from the global ozonesonde network. Monthly mean zonal mean ozone concentrations in mixing ratio and number density are provided in 5∘ latitude bins, spanning 70 altitude levels (1 to 70 km), or 70 pressure levels that are approximately 1 km apart (878.4 to

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Hall, Patricia L., Hong Li, Arthur F. Hagar, S. Caleb Jerris, Angela Wittenauer, and William Wilcox. "Newborn Screening for X-Linked Adrenoleukodystrophy in Georgia: Experiences from a Pilot Study Screening of 51,081 Newborns." International Journal of Neonatal Screening 6, no. 4 (2020): 81. http://dx.doi.org/10.3390/ijns6040081.

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We screened 51,081 newborns for X-linked adrenoleukodystrophy (ALD) using a two-tiered strategy quantifying very long chain lysophosphatadylcholines (LPC). Our testing strategy used flow injection tandem mass spectrometry for the first-tier analysis of LPCs, and second-tier quantification of C26:0 LPC using liquid chromatography tandem mass spectrometry. There were 364 specimens considered abnormal using our first-tier algorithm that relied on the four LPC measurements and post-analytical tools. Second-tier test results were reported as normal or abnormal based on a cutoff for the single analy

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Jusriana, Jusriana, Muh Yunus, and Halima Husain. "Analisis Pemahaman Konsep Menggunakan Instrumen Three Tier Multiple Choice Diagnostic Test Pada Materi Asam Basa Kelas XI SMA Negeri 9 Bone." Chemica: Jurnal Ilmiah Kimia dan Pendidikan Kimia 23, no. 1 (2022): 99. http://dx.doi.org/10.35580/chemica.v23i1.34000.

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ABSTRAKPenelitian ini bertujuan untuk menganalisis pemahaman konsep peserta didik kelas XI IPA 3 SMA Negeri 9 Bone pada materi asam basa. Subjek dalam penelitian ini adalah peserta didik kelas XI IPA 3 yang berjumlah 12 peserta didik. Instrumen yang digunakan adalah tes diagnostik three tier multiple choice yang terdiri dari 20 butir soal. Instrumen ini telah divalidasi ahli dan divalidasi item dengan nilai reliabilitas tingkat 1 (Pilihan jawaban) 0,8100 dan tingkat 2 (Pilihan alasan) 0,8733 termasuk kategori sangat tinggi. Hasil penelitian diperoleh persentase peserta didik yang paham konsep

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Liu, Wanqi, Dunyou Wang, and Junfeng Ren. "Methanol synthesis from CO2/H2 on Cu (1 0 0): Two-tier ab initio molecular dynamics study." Applied Surface Science 505 (March 2020): 144528. http://dx.doi.org/10.1016/j.apsusc.2019.144528.

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20

Weeks, J. M., and S. D. W. Comber. "Ecological risk assessment of contaminated soil." Mineralogical Magazine 69, no. 5 (2005): 601–13. http://dx.doi.org/10.1180/0026461056950274.

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AbstractThe basis for an ecological risk assessment based on meeting the needs of recent UK and EU legislation is described. The background to the framework and the legislative driver and relevant definitions of harm are provided, prior to an overview of the proposed ecological risk assessment process, which has been broken down into a Tiered approach. Tier 0 requires the establishment of a conceptual site model, where potential contaminant-pathway-receptor linkages are sought and, assuming they are identified, lead on to higher Tier assessments. Tier 1 relies largely on chemical analysis of s

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Sebastiani, Giada, Jovana Milic, Adriana Cervo, et al. "Two-Tier Care Pathways for Liver Fibrosis Associated to Non-Alcoholic Fatty Liver Disease in HIV Mono-Infected Patients." Journal of Personalized Medicine 12, no. 2 (2022): 282. http://dx.doi.org/10.3390/jpm12020282.

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(1) Background: Developing strategies to identify significant liver fibrosis in people with HIV (PWH) is crucial to prevent complications of non-alcoholic fatty liver disease (NAFLD). We aim to investigate if five simple serum biomarkers applied to PWH can optimize a care pathway to identify significant liver fibrosis defined by transient elastography (TE). (2) Methods: A two-tier fibrosis pathway was applied to three prospective cohorts of PWH undergoing TE with CAP. NAFLD was diagnosed as a controlled attenuation parameter ≥ 248 dB/m. Five simple fibrosis biomarkers (FIB-4 < 1.3, BARD sco

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Borghesi, Andrea, Santi Carmine Di, Martin Molan, et al. "M100 ExaData: a data collection campaign on the CINECA's Marconi100 Tier-0 supercomputer." Scientific Data 10 (May 12, 2023): 288. https://doi.org/10.1038/s41597-023-02174-3.

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Supercomputers are the most powerful computing machines available to society. They play a central role in economic, industrial, and societal development. While they are used by scientists, engineers, decision-makers, and data-analyst to computationally solve complex problems, supercomputers and their hosting datacenters are themselves complex power-hungry systems. Improving their efficiency, availability, and resiliency is vital and the subject of many research and engineering efforts. Still, amajor roadblock hinders researchers: dearth of reliable data describing the behavior of production su

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Rahayu, Ratna Dwi. "Miskonsepsi Mahasiswa Menggunakan Four-Tier Diagnostic Test." SIMETRIS 15, no. 2 (2021): 18–21. http://dx.doi.org/10.51901/simetris.v15i2.223.

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Dalam pembelajaran Fisika, tidak jarang ditemukan adanya miskonsepsi yang dialami oleh mahasiswa, termasuk pada sub-materi Fluida Dinamis yaitu Azas Kontinuitas. Penelitian ini bertujuan untuk mengidentifikasi miskonsepsi yang terjadi pada materi ajar Azas Kontinuitas serta mengidentifikasi kelemahan konsep sebagai penyebab terjadinya pada materi ajar Azas Kontinuitas serta mengidentifikasi kelemahan konsep sebagai penyebab terjadinya miskonsepsi tersebut. Penelitian dilakukan terhadap 37 mahasiswa di Sekolah Tinggi Teknologi Ronggolawe jurusan Teknik Mesin dengan metode penelitian one shoot r

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Artem, Pavlychenko, Adamchuk Andrii, Shustov Oleksandr, and Anisimov Oleh. "JUSTIFICATION OF DUMP PARAMETERS IN CONDITIONS OF HIGH WATER SATURATION OF SOILS." TECHNOLOGY AUDIT AND PRODUCTION RESERVES 6, no. 3(56) (2020): 22–26. https://doi.org/10.15587/2706-5448.2020.218139.

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<em>The object of research is the stability parameters of the massif of a single-tier dump of soft overburden rocks with a flooded slope when it is formed by a dragline excavator. One of the most problematic areas is determining the safe distance of the dragline excavator from the upper edge of the slope in the conditions of the formation of a single-tier dump of soft overburden rocks, flooded with water.</em> <em>The calculation of the width of the prism of possible shift was carried out using the Rocscience Slide software, which, taking into account the parameters of the slope and the physic

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McKay, Alannah K. A., Trent Stellingwerff, Ella S. Smith, et al. "Defining Training and Performance Caliber: A Participant Classification Framework." International Journal of Sports Physiology and Performance 17, no. 2 (2022): 317–31. http://dx.doi.org/10.1123/ijspp.2021-0451.

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Throughout the sport-science and sports-medicine literature, the term “elite” subjects might be one of the most overused and ill-defined terms. Currently, there is no common perspective or terminology to characterize the caliber and training status of an individual or cohort. This paper presents a 6-tiered Participant Classification Framework whereby all individuals across a spectrum of exercise backgrounds and athletic abilities can be classified. The Participant Classification Framework uses training volume and performance metrics to classify a participant to one of the following: Tier 0: Se

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Liu, Lu, Runyi Gao, and Li Zhang. "An Equity Evaluation of Healthcare Accessibility across Age Strata Using the G2SFCA Method: A Case Study in Karamay District, China." Land 13, no. 8 (2024): 1259. http://dx.doi.org/10.3390/land13081259.

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Equitable access to healthcare services is essential for residents’ well-being and social equity, requiring the rational spatial distribution of healthcare facilities in urban planning. Compared with major studies on the spatial accessibility and equity of healthcare services in first-tier cities, second-tier cities, which form the foundational structure of the global urban system, have not be given sufficient attention. Therefore, this study takes Karamay District in Karamay as a case study to analyze the spatial equity of healthcare services using place-based accessibility measures. For acce

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Sholihat, Fitri Nurul, Achmad Samsudin, and Muhamad Gina Nugraha. "Identifikasi Miskonsepsi dan Penyebab Miskonsepsi Siswa Menggunakan Four-Tier Diagnostic Test Pada Sub-Materi Fluida Dinamik: Azas Kontinuitas." Jurnal Penelitian & Pengembangan Pendidikan Fisika 3, no. 2 (2017): 175–80. http://dx.doi.org/10.21009/1.03208.

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In Physics learning, misconception is often experienced by students, including on Dynamic Fluid materials namely Continuity Platform. This study aims to identify misconceptions that occur in the subject matter of the Continuity Platform and identify the concept's weakness as the cause of the misconception. The study was conducted on 37 students in one high school in Bandung with one shoot research method. The diagnosis of student misconceptions is done using a four-tier diagnostic test instrument which is the development of a three-tier test instrument by adding a confidence level to the third

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Bhole, Rohini, Nitin Goyal, Katherine Nearing, et al. "Implications of limiting mechanical thrombectomy to patients with emergent large vessel occlusion meeting top tier evidence criteria." Journal of NeuroInterventional Surgery 9, no. 3 (2016): 225–28. http://dx.doi.org/10.1136/neurintsurg-2015-012206.

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BackgroundRecent guidelines for endovascular management of emergent large vessel occlusion (ELVO) award top tier evidence to the same selective criteria in recent trials. We aimed to understand how guideline adherence would have impacted treatment numbers and outcomes in a cohort of patients from a comprehensive stroke center.MethodsA retrospective observational study was conducted using consecutive emergent endovascular patients. Mechanical thrombectomy (MT) was performed with stent retrievers or large bore clot aspiration catheters. Procedural outcomes were compared between patients meeting,

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Bodeker, G. E., B. Hassler, P. J. Young, and R. W. Portmann. "A vertically resolved, global, gap-free ozone database for assessing or constraining global climate model simulations." Earth System Science Data 5, no. 1 (2013): 31–43. http://dx.doi.org/10.5194/essd-5-31-2013.

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Abstract. High vertical resolution ozone measurements from eight different satellite-based instruments have been merged with data from the global ozonesonde network to calculate monthly mean ozone values in 5° latitude zones. These ''Tier 0'' ozone number densities and ozone mixing ratios are provided on 70 altitude levels (1 to 70 km) and on 70 pressure levels spaced ~ 1 km apart (878.4 hPa to 0.046 hPa). The Tier 0 data are sparse and do not cover the entire globe or altitude range. To provide a gap-free database, a least squares regression model is fitted to the Tier 0 data and then evaluat

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Bodeker, G. E., B. Hassler, P. J. Young, and R. W. Portmann. "A vertically resolved, global, gap-free ozone database for assessing or constraining global climate model simulations." Earth System Science Data Discussions 5, no. 2 (2012): 999–1033. http://dx.doi.org/10.5194/essdd-5-999-2012.

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Abstract. High vertical resolution ozone measurements from eight different satellite-based instruments have been merged with data from the global ozonesonde network to calculate monthly mean ozone values in 5° latitude zones. These "Tier 0" ozone number densities and ozone mixing ratios are provided on 70 altitude levels (1 to 70 km) and on 70 pressure levels spaced ~1 km apart (878.4 hPa to 0.046 hPa). The Tier 0 data are sparse and do not cover the entire globe or altitude range. To provide a gap-free database, a least squares regression model is fitted to the Tier 0 data and then evaluated

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A.A. Istri Rai Sudiatmika and I Wayan Subagia. "Profil Miskonsepsi Mahasiswa Prodi S2 Pendidikan IPA pada Materi Optik menggunakan Tes Diagnostik Four Tier Test." Wahana Matematika dan Sains: Jurnal Matematika, Sains, dan Pembelajarannya 16, no. 2 (2022): 45–52. https://doi.org/10.23887/wms.v16i2.41118.

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Penelitian ini bertujuan untuk mendeskripsikan miskonsepsi mahasiswa pada konsep optik. Jenis penelitian ini adalah penelitian deskriptif. Populasi penelitian ini sebanyak 15 mahasiswa program studi S2 Pendidikan IPA. Sampel penelitian diambil dengan menggunakan teknik quota sampling yaitu semua populasi menjadi sample, sehingga sample penelitian berjumlah 15 orang. Data miskonsepsi dikumpulkan dengan 7 soal tes diagnostik dan dianalisis dengan metode Four Tier Test. Hasil analisis menunjukkan bahwa: four-tier diagnostic test dapat digunakan untuk mengetahui miskonsepsi yang dialami mahasiswa

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Azma, Nur, Sitti Mania, and Baharuddin. "Development of A Diagnostic Test in The Form of A Three Tier Essay Test to Identify Understanding of Mathematical Concepts on The Material of The System of Linear Equations of Three Variables." Alauddin Journal of Mathematics Education 6, no. 1 (2024): 1–23. http://dx.doi.org/10.24252/ajme.v6i1.43850.

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This study aims to develop and produce a three tier essay test instrument to identify understanding of mathematical concepts on the material of the system of linear equations of three variables (SPLTV). This research is categorized as development research with the Formative Research development model (Tessmer) through the stages of (1) preliminary, (2) self evaluation, (3) prototyping, and (4) field test. The test subjects in this study were students of class X.2 MAN 1 Soppeng. This development research produces (1) a diagnostic test instrument in the form of a three tier essay test which is u

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Tom, Martin C., Richard B. Ross, Shlomo A. Koyfman, et al. "Clinical Factors Associated With Cost in Head and Neck Cancer: Implications for a Bundled Payment Model." Journal of Oncology Practice 15, no. 6 (2019): e560-e567. http://dx.doi.org/10.1200/jop.18.00665.

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PURPOSE: To determine which factors influence cost in head and neck cancer (HNC) to inform the development of a bundled payment model (BPM). METHODS: Patients with stages 0 to IVB (by American Joint Commission on Cancer, 7th edition) HNC of various sites and histology treated definitively at a single tertiary care center during 2013 were included. Clinical variables and direct cost data were obtained, and their associations were investigated using χ2, t, Wilcoxon rank sum, and analysis of variance testing. Results were used to develop a BPM. RESULTS: One hundred fifty patients were included; 8

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Zuhair, Hiba, Ali Selamat, and Ondrej Krejcar. "A Multi-Tier Streaming Analytics Model of 0-Day Ransomware Detection Using Machine Learning." Applied Sciences 10, no. 9 (2020): 3210. http://dx.doi.org/10.3390/app10093210.

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Desktop and portable platform-based information systems become the most tempting target of crypto and locker ransomware attacks during the last decades. Hence, researchers have developed anti-ransomware tools to assist the Windows platform at thwarting ransomware attacks, protecting the information, preserving the users’ privacy, and securing the inter-related information systems through the Internet. Furthermore, they utilized machine learning to devote useful anti-ransomware tools that detect sophisticated versions. However, such anti-ransomware tools remain sub-optimal in efficacy, partial

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Laksono, Pandu Jati. "PENGEMBANGAN DAN PENGGUNAAN INSTRUMEN TWO-TIER MULTIPLE CHOICE PADA MATERI TERMOKIMIA UNTUK MENGUKUR KEMAMPUAN BERPIKIR KRITIS." Orbital: Jurnal Pendidikan Kimia 2, no. 2 (2019): 80–92. http://dx.doi.org/10.19109/ojpk.v2i2.2646.

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Penelitian ini bertujuan untuk mengembangkan instrumen tes Two-Tier Multiple Choice pada materi termokimia menjadi instrumen penilaian yang mampu mengukur keterampilan berpikir kritis. Instrumen yang dikembangkan perlu diujikan kelayakannya ditinjau dari validitas logis para ahli dan instrumen penilaian Two-Tier Multiple Choice yang dikembangkan ditinjau dari validitas empiris yaitu reliabilitas, analisis kualitas butir soal, dan analisis pengecoh yang dapat dikategorikan soal yang baik. Penelitian ini dikategorikan sebagai penelitian pengembangan. Instrumen tes yang dikembangkan adalah Two-Ti

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Fendler, Wolfgang Peter, Madeleine J. Karpinski, Sebastian Hoberück, et al. "Updated prostate cancer risk groups by PSMA-PET PROMISE (PPP2): Results from an international multi-centre registry study." Journal of Clinical Oncology 43, no. 16_suppl (2025): 5045. https://doi.org/10.1200/jco.2025.43.16_suppl.5045.

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5045 Background: We previously established prognostic two-tier risk nomograms based on PSMA-PET and Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE) criteria in a large single-centre cohort. Here, we validate three-tier risk stratification by PSMA-PET PROMISE (PPP2) in a large international multi-centre registry study for prostate cancer survival. Methods: We included prostate cancer patients who underwent PSMA-PET at 20 hospitals in EU, USA or Australia between 2013 and 2022. PSMA-PET was standardized by PROMISE version 2 (V2). Total lesion count, total tumour volume, PSMA

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Luo, Xunda, Nirag Jhala, Jasvir S. Khurana, Christopher Fundakowski, Darshana N. Jhala, and He Wang. "Moving Toward a Systematic Approach for Reporting Salivary Gland Cytopathology: An Institutional Experience and Literature Review." Archives of Pathology & Laboratory Medicine 143, no. 6 (2018): 664–69. http://dx.doi.org/10.5858/arpa.2017-0283-ra.

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Context.— Despite the clinical utility of fine-needle aspiration for the diagnosis of salivary pathologies, salivary lesions remain one of the most challenging areas in cytopathology. This is partially because there is no consensus on how to report salivary gland cytopathology, which has resulted in inconsistent terminology among institutions and individual cytopathologists and in confusion in communication among cytopathologists and ordering providers. Objective.— To summarize our experience with an institutional salivary gland cytopathology reporting system, as an initiative to promote colla

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Crisosto, Carlos H., Lluís Palou, David Garner, and Donald A. Armson. "Concentration by Time Product and Gas Penetration after Marine Container Fumigation of Table Grapes with Reduced Doses of Sulfur Dioxide." HortTechnology 12, no. 2 (2002): 241–45. http://dx.doi.org/10.21273/horttech.12.2.241.

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Reduced doses of sulfur dioxide (SO2) were evaluated for the fumigation of marine containers with respect to the concentration × time (CT) product and gas penetration. Two commercial export containers were loaded at 32 °F (0 °C) with 20 metric pallets [40 × 48 inches (102.5 × 123.1 cm)] comprised of 72 expanded polystyrene foam boxes (12 tiers, 6 boxes/tier) of table grapes (Vitis vinifera) and fumigated with 1.0 and 0.5 lb (0.454 and 0.227 kg) SO2, respectively. A third marine container was loaded with 20 metric pallets comprised of 84 plastic boxes of table grapes (14 tiers, 6 boxes/tier) an

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Mares Beltran, Carlos F., Christina G. Tise, Rebekah Barrick, et al. "Newborn Screening for X-Linked Adrenoleukodystrophy (X-ALD): Biochemical, Molecular, and Clinical Characteristics of Other Genetic Conditions." Genes 15, no. 7 (2024): 838. http://dx.doi.org/10.3390/genes15070838.

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The state of California (CA) added X-linked adrenoleukodystrophy (X-ALD) to newborn screening (NBS) in 2016 via the measurement of C26:0-lysophosphatidylcholine (C26:0-LPC) in a two-tier fashion, followed by sequencing of the ABCD1 gene. This has resulted in the identification of individuals with genetic conditions beyond X-ALD that can also result in elevated C26:0-LPC by NBS. We describe the biochemical, molecular, and clinical characteristics of nine patients from two metabolic centers in California who screened positive by NBS for elevated C26:0-LPC between 2016 and 2022 and were ultimatel

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Negrete Carballo, Eduardo, and Fidel David Huitzil Melendez. "Prevalence of advanced colorectal neoplasia according to risk categories at screening colonoscopy in a tertiary referral center." Journal of Clinical Oncology 36, no. 4_suppl (2018): 578. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.578.

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578 Background: Colorectal cancer (CRC) is the third most common cancer in the world. There is strong evidence that screening for colorectal cancer improves survival in conutries with high incidence. Although Mexico is considered a country with a low incidence of CRC, 4694 potentially preventable deaths occur every year. There is no established CRC screening program in our country, risk stratification of the target populations to be screened may bring potential advantages, making the strategy more cost-effective. The Asia-Pacific Colorectal Screening (APCS) score, is a validated risk-stratific

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Kominakis, A., G. Nitter, D. Fewson, and E. Rogdakis. "Evaluation of the efficiency of alternative selection schemes and breeding objectives in dairy sheep of Greece." Animal Science 64, no. 3 (1997): 453–61. http://dx.doi.org/10.1017/s1357729800016064.

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AbstractThe genetic and economic efficiency of alternative selection schemes and breeding objectives for the Karagouniki dairy sheep in Greece was investigated by model calculations. Criteria of efficiency were the annual genetic gain for the aggregate breeding value, the profit per ewe in the population and the annual selection responses for single traits. The introduction of a two-tier selection scheme, where the recorded ewes are separated into a nucleus and a pre-nucleus, was found superior in both genetic and economic terms for a breeding objective comprising the traits milk yield and num

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dell’Agnello, Luca, Tommaso Boccali, Daniele Cesini, et al. "INFN Tier–1: a distributed site." EPJ Web of Conferences 214 (2019): 08002. http://dx.doi.org/10.1051/epjconf/201921408002.

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The INFN Tier-1 center at CNAF has been extended in 2016 and 2017 in order to include a small amount of resources (∼ 22 kHS06 corresponding to ∼ 10% of the CNAF pledges for LHC in 2017) physically located at the Bari-ReCas site (∼ 600 km distant from CNAF). In 2018, a significant fraction of the CPU power (∼ 170 kHS06, equivalent to ∼ 50% of the total CNAF pledges) is going to be provided via a collaboration with the PRACE Tier-0 CINECA center (a few km from CNAF), thus building a truly geographically distributed (WAN) center. The two sites are going to be interconnected via an high bandwidth

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Kalinitchenko, Valery Petrovich, Alexey Pavlovich Glinushkin, Vladimir Konstantinovich Sharshak, et al. "Intra-Soil Milling for Stable Evolution and High Productivity of Kastanozem Soil." Processes 9, no. 8 (2021): 1302. http://dx.doi.org/10.3390/pr9081302.

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The long-term field experiment on the Kastanozem showed that the standard moldboard plowing to a depth of 22 cm (control), chiseling to a depth of 35 cm, and three-tier plowing (machine type PTN–40) to a depth of 45 cm was incapable of providing a stable soil structure and aggregate system. The transcendental Biogeosystem Technique (BGT*) methodology for intra-soil milling of the 20–45 cm layer and the intra-soil milling PMS–70 machine were developed. The PMS–70 soil processing provided the content of 1–3 mm sized aggregate particle fraction in the illuvial horizon of about 50 to 60%, which wa

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P, Potiraj, and Srinivasan G. "ÉVALUATION OF COTTON BASED MULTI-TIER CROPPING SYSTEM UNDER RAINFED CONDITIONS." Madras Agricultural Journal 79, July (1992): 363–69. http://dx.doi.org/10.29321/maj.10.a01767.

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Field experiment was conducted at Tamil nadu Agricultural University, coimbatore during 1986-87 to evaluate the performance of multi-tier crop combinations under rainfed conditions. The results revealed that the physiological parameters viz., Net Assimilation Rate, Relative Growth Rate and Crop Growth Rate were more influenced by nitrogen levels than by crop combinations. Introduction of tall third tier crop was not found to be advantageous because of completion for resources particularly moisture, which was reflected in plant water relations. The highest yield in terms of cotton equivalent wa

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Nurchis, Mario Cesare, Francesca Clementina Radio, Luca Salmasi, et al. "Cost-Effectiveness of Whole-Genome vs Whole-Exome Sequencing Among Children With Suspected Genetic Disorders." JAMA Network Open 7, no. 1 (2024): e2353514. http://dx.doi.org/10.1001/jamanetworkopen.2023.53514.

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ImportanceThe diagnosis of rare diseases and other genetic conditions can be daunting due to vague or poorly defined clinical features that are not recognized even by experienced clinicians. Next-generation sequencing technologies, such as whole-genome sequencing (WGS) and whole-exome sequencing (WES), have greatly enhanced the diagnosis of genetic diseases by expanding the ability to sequence a large part of the genome, rendering a cost-effectiveness comparison between them necessary.ObjectiveTo assess the cost-effectiveness of WGS compared with WES and conventional testing in children with s

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Juliani, Juliani, Yusrizal Yusrizal, and Ismul Huda. "Development of Four Tier Multiple Choice Diagnostic Tests to Know Students' Misconceptions in Science Learning." Jurnal Penelitian Pendidikan IPA 7, no. 4 (2021): 763–69. http://dx.doi.org/10.29303/jppipa.v7i4.854.

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Penelitian ini bertujuan untuk mengetahui kualitas instrumen tes diagnostik pilihan ganda four tier dan tingkat miskonsepsi peserta didik. Metode penelitian yang digunakan yaitu research and development (R&D). Populasi dalam penelitian ini adalah peserta didik kelas IX MTs Negeri 2 Aceh Besar. Jumlah sampel terdiri 112 peserta didik pada kelompok A, masing-masing kelas terdiri dari 16 peserta didik di masa pandemi Covid-19. Instrumen penelitian yang digunakan yaitu soal tes diagnostik pilihan ganda four tier. Teknik analisis data pada uji validasi diperoleh nilai koefesien Aiken’s V tinggi

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Chege, Gerald K., Rosamund E. Chapman, Alana T. Keyser, et al. "Heterologous Immunization with Improved HIV-1 Subtype C Vaccines Elicit Autologous Tier 2 Neutralizing Antibodies with Rapid Viral Replication Control After SHIV Challenge." Viruses 17, no. 2 (2025): 277. https://doi.org/10.3390/v17020277.

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We previously reported on HIV vaccines that elicited autologous Tier 2 neutralizing antibodies (nAbs) in rabbits. In the current study, we sought to establish a proof of concept that HIV vaccines using identical designs elicit Tier 2 nAbs in arhesus macaque (RM) model. DNA and MVA vaccines expressing SIV Gag and HIV-1 Env antigens were constructed, and in vitro expression was confirmed. A soluble envelope protein (gp140 Env) was expressed from a stable HEK293 cell line and purified using lectin affinity and size exclusion chromatography. The expression and secretion of SIV Gag and HIV-1 Env by

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Treasure, Graham, David M. Anderson, Lauren Hatcher, et al. "Plan Selection, Enrollee Risk, and Health Spending on the Patient Protection and Affordable Care Act Individual Marketplaces, 2019." JAMA Network Open 6, no. 3 (2023): e234529. http://dx.doi.org/10.1001/jamanetworkopen.2023.4529.

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ImportanceThe Patient Protection and Affordable Care Act (ACA) individual marketplaces are a source of insurance for millions of residents in the US. However, the association between enrollee risk, health spending, and metal tier selection remains unclear.ObjectivesTo describe individual marketplace enrollees’ metal tier selections by risk score and assess enrollees’ health spending by metal tier, risk score, and spending type.Design, Setting, and ParticipantsThis retrospective, cross-sectional study analyzed claims data from the Wakely Consulting Group ACA database, a deidentified claims data

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Zhang, Hui, Yanji Yi, Yibin Wang, et al. "Pixelated Micropolarizer Array Based on Carbon Nanotube Films." Nanomaterials 13, no. 3 (2023): 391. http://dx.doi.org/10.3390/nano13030391.

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A micropolarizer array (MPA) that can be integrated into a scientific camera is proposed as a real-time polarimeter that is capable of extracting the polarization parameters. The MPA is based on highly aligned carbon nanotube (CNT) films inspired by their typical anisotropy and selectivity for light propagation over a wide spectral range. The MPA contains a dual-tier CNT pixel plane with 0° and 45° orientations. The thickness of the dual-tier structure of the CNT-based MPA is limited to less than 2 μm with a pixel size of 7.45 μm × 7.45 μm. The degree of polarization of the CNT-MPA reached 93%

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Miller, Paul, Andrew W. Ellis, and Stephen Keighton. "A Preliminary Assessment of Using Spatiotemporal Lightning Patterns for a Binary Classification of Thunderstorm Mode." Weather and Forecasting 30, no. 1 (2015): 38–56. http://dx.doi.org/10.1175/waf-d-14-00024.1.

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Abstract This study provides a preliminary, regional assessment of the viability of using spatiotemporal lightning patterns to classify storms into single- versus multi- and supercell storm modes. Total lightning flashes (intracloud and cloud-to-ground flashes) occurring during the afternoon and evening of the period May–August 2012 within an area of the central Appalachian Mountains region were grouped based on their spatial and temporal characteristics using single-linkage clustering. The resulting discrete thunderstorm clusters were characterized in terms of duration, motion, areal extent,

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