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Dissertations / Theses on the topic 'TIM3'

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Published: 4 June 2021
Last updated: 14 February 2022

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1

Barlow, J. L. "Investigation of the immunomodulatory roles of Tim1 and Tim3 in the lung." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596370.

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To specifically investigate the necessity for Tim1 and Tim3 during an ovalbumin- (OVA) induced, type 2-mediated allergic lung model, havcr1-/- and havcr2-/- mice were backcrossed to the BALB/c background over six generations. The allergic lung response was assessed using unrestrained whole body plethysmography to test lung function and, by analysing, cellular infiltration into the bronchoalveolar lavage (BAL), mucus production in the lung, eosinophilia, the cytokine and proliferative response of OVA-restimulated lymph node cells, and OVA-specific serum immunoglobulin production. The data demonstrate that whilst Tim3 is expressed in the lung by CD4+CD25+, and CD11c+ cells, it is not essential for any aspect of the allergic lung response tested. Tim1 was also expressed in the lung following an OVA-induced type 2 immune response, but only on CD19+B cells. Whilst Tim1 was not essential for many aspects of the allergic lung response which were tested, OVA treated havcr1-/- mice did show a statistically significant deficit in blood and BAL eosinophils. To further understand the role of Tim3 in the naïve immune response, in vitro, a Tim3-human IgG1 fusion protein (Tim3Ig) was generated. Similarly, as Tim5 is not expressed in naïve tissue, a Tim5-human IgG1 fusion protein (Tim5Ig) was also generated as a control. Flow cytometric analysis using Tim3Ig led to the detection of an unknown binding partner for Tim3Ig on CD19/B220+ B cells, but not on CD3+ T cells. The interaction of Tim3Ig with B cells led to a Toll4- and FcgRII receptor-independent increase in proliferation and upregulation of the lymphocyte activation marker CD69, in a naive, as well as in an anti-IgM stimulated B cell population. These data demonstrate the identification of a novel function for Tim3 in the regulation of B cell proliferation and activation.
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2

Zhang, Shengtao. "Klonierung, Expression und initiale Charakterisierung vom humanen TIM3." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972570357.

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3

Jacques, Miye K. "Role of Tim3 in Mediating T Cell Exhaustion During Chronic Mycobacterium Tuberculosis Infection." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/912.

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Mycobacterium tuberculosis infection is one of the leading causes of mortality worldwide. One third of the population is estimated to be infected, however only 5-10% of those individuals can transmit the disease. While T cell immunity initially limits mycobacterium growth, it is unclear why T cell immunity fails to sterilize the infection and prevent subsequent recrudescence. One hypothesis is T cell exhaustion is mediating the failure of T cell immunity late during infection. Here we show the development of T cell exhaustion during chronic infection, and that the inhibitory receptor T cell-immunoglobulin and mucin domain containing 3 (TIM3) mediates the development of T cell exhaustion. TIM3 accumulates on the surface of T cells throughout the course of infection and there is a subsequent decrease in effector cytokine production, such as IL-2, TNFα, and IFNγ. Furthermore, antibody blockade of TIM3 restores T cell function and improves bacterial control. Our results show that TIM3 is mediating T cell exhaustion during chronic TB infection and leading to suboptimal bacterial control.
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Jacques, Miye K. "Role of Tim3 in Mediating T Cell Exhaustion During Chronic Mycobacterium Tuberculosis Infection." eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/912.

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Mycobacterium tuberculosis infection is one of the leading causes of mortality worldwide. One third of the population is estimated to be infected, however only 5-10% of those individuals can transmit the disease. While T cell immunity initially limits mycobacterium growth, it is unclear why T cell immunity fails to sterilize the infection and prevent subsequent recrudescence. One hypothesis is T cell exhaustion is mediating the failure of T cell immunity late during infection. Here we show the development of T cell exhaustion during chronic infection, and that the inhibitory receptor T cell-immunoglobulin and mucin domain containing 3 (TIM3) mediates the development of T cell exhaustion. TIM3 accumulates on the surface of T cells throughout the course of infection and there is a subsequent decrease in effector cytokine production, such as IL-2, TNFα, and IFNγ. Furthermore, antibody blockade of TIM3 restores T cell function and improves bacterial control. Our results show that TIM3 is mediating T cell exhaustion during chronic TB infection and leading to suboptimal bacterial control.
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5

Zhang, Shengtao [Verfasser], K. [Gutachter] Erb, O. [Gutachter] Liesenfeld, and T. [Gutachter] Kamradt. "Klonierung, Expression und initiale Charakterisierung vom humanen TIM3 / Shengtao Zhang ; Gutachter: K. Erb, O. Liesenfeld, T. Kamradt." Berlin : Humboldt-Universität zu Berlin, 2004. http://d-nb.info/1207664405/34.

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6

Stein, Julia [Verfasser], and Marion [Akademischer Betreuer] Subklewe. "Bispezifische Antikörper in der Immuntherapie der Akuten Myeloischen Leukämie: Charakterisierung eines TIM3/CD3-Konstrukts in Hinblick auf Resistenzmechanismen / Julia Stein ; Betreuer: Marion Subklewe." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://nbn-resolving.de/urn:nbn:de:bvb:19-283412.

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7

Takeuchi, Yasuhide. "Frequent germline mutations of HAVCR2 in sporadic subcutaneous panniculitis-like T-cell lymphoma." Kyoto University, 2020. http://hdl.handle.net/2433/253177.

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8

Joelsons, Gabriel. "Avaliação molecular das disfunções subclínicas do enxerto renal : quantificação gênica de perforina, TIM3, FOXP3, TGF-β, CTGF e CD138 no sangue periférico de pacientes com função estável que realizaram biópsia protocolar no terceiro mês após o transplante renal." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/106762.

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Introdução: A sobrevivência em curto prazo dos transplantes renais tem melhorado notavelmente nas últimas duas décadas. No entanto, a sobrevivência em longo prazo de enxertos e pacientes ainda são muito inferiores ao desejado e a maioria dos enxertos são perdidos por falecimento dos receptores e deterioração crônica da função do enxerto. Acredita-se que a maior parte das lesões que resultam em encurtamento da sobrevida do enxerto se iniciam logo após o transplante e muitas vezes são subclínicas. O desenvolvimento de biomarcadores não invasivos para identificar com precisão as lesões sub-clínicas, sem a necessidade de biópsias de protocolo, seria um grande passo para a prática clínica de transplantes de órgãos, uma vez que permitiria o reconhecimento precoce de eventos de agressões ao enxerto e poderia levar a adequadas ações terapêuticas potencialmente propiciando sobrevida mais prolongada dos aloenxertos. Objetivos: O objetivo do presente estudo foi avaliar o potencial diagnóstico de agressões sub-clínicas da análise molecular não-invasiva da expressão gênica de leucócitos do sangue periférico em receptores de transplante renal com função estável em curto prazo. Métodos: Cento e trinta e seis pacientes renais com função estável do enxerto foram arrolados no estudo e realizaram biópsia protocolar no 3º mês póstransplante. Foram coletadas amostras de sangue periférico concomitantemente para realizarmos a quantificação da expressão gênica de perforina, TIM3, FOXP3, TGF-B, CTGF e CD138 através da metodologia de PCR em tempo real. Resultados: Trinta e nove pacientes foram diagnosticados com rejeição aguda (28,7%), sendo 33 destes com alterações borderline, 5 com rejeição aguda Banff IA e um paciente com rejeição Banff IB, vinte pacientes apresentaram fibrose intersticial e atrofia tubular (14,7%), sete apresentaram necrose tubular aguda (5,1%), três infecções pelo vírus do polioma (2,2%) e um caso de nefrotoxicidade aguda por inibidores da calcineurina (0,8%). A mensuração da expressão gênica foi realizada através de qPCR e os pacientes com disfunção do enxerto apresentaram expressões diminuídas de perforina, TIM3, FOXP3 e TGF-β em relação aos pacientes com rejeição aguda e histologia normal do enxerto. Outras análises demonstraram que a perforina, TIM3 e FOXP3 também são capazes de excluir o diagnóstico de rejeição aguda, com valores preditivos negativos (VPN) de 83%, 83% e 79,6%, respectivamente. Em uma análise combinada dos 3 genes associados o VPN para rejeição aguda foi de 86.4%. A avaliação do RNA mensageiro dos genes TGF-B e CTGF mostrou que eles estão hiperexpressos nos enxertos com fibrose intersticial e atrofia tubular. Conclusões: Existe uma elevada incidência de agressões sub-clínicas dos enxertos renais que podem ser detectadas por biópsias protocolares. A mensuração do RNA mensageiro, em amostras do sangue periférico, mostrou ser uma ferramenta de potencial utilidade em identificar essas agressões de forma não-invasiva.
Background: Short term survival of kidney transplants has improved remarkably over the last two decades. However, long term survival of grafts and patients are still much lower than desired and most of the grafts are lost by recipients’ death and chronic graft function deterioration. It is believed that most of the injuries that result in graft shortening survival are initiated early after transplantation and many times are subclinical. The development of noninvasive biomarkers to accurately identify sub-clinical injuries, without the need of protocol biopsies, would be a major step forward in the practice of clinical organ transplantation since it would allow the early recognition of graft insulting events and lead to proper therapeutic actions potentially leading to more prolonged allograft survivals Objective: The aim of the present study was to evaluate the diagnosis potential of the non-invasive molecular analyzes of peripheral blood leukocytes gene expression in stable kidney recipients in the short-term. Methods: One hundred and thirty-six patients were enrolled in this study and underwent protocol biopsies at 3 months after grafting. Peripheral blood samples were collected concomitantly for the gene expression quantitation of perforin, TIM3, FOXP3, TGF-B, CTGF and CD138 through qPCR methodology. Results: Thirty-nine patients were diagnosed as acute rejection (28.7%), being 33 with borderline histological changes, 5 Banff IA acute rejection and 1 patient with Banff IB acute rejection, twenty patients had interstitial fibrosis and tubular atrophy (14.7%), seven had acute tubular necrosis (5.1%), three had poliomavirus infection (2.2%) and one patient had calcineurin inhibitor toxicity (0.8%). Gene expression was measured through qPCR and patients with graft dysfunction presented lower expressions of perforin, TIM3, FOXP3 and TGF-β than patients with acute rejection and normal graft histology. Other analyzes showed that perforin, TIM3 and FOXP3 are also able to rule out acute rejection, with negative predictive values (NPV) of 83%, 83% and 79.6% respectively. In a combined analysis of the 3 genes associated the NPV was 86.4%. CTGF and TGF-B mRNA were overexpressed in grafts with interstitial fibrosis and tubular atrophy. Conclusions: An elevated incidence of sub-clinical injuries can be detected by protocol biopsies of stable grafts. The evaluation of mRNA in the peripheral blood has shown to be a potentially useful tool to uncover these injuries noninvasively.
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9

Adam, Alexander. "Tim8 und Tim9, neue Komponenten der TIM22 Präproteintranslokase in Mitochondrien." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-31385.

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10

Feld, Timo [Verfasser]. "Response time analyses of adaptive variable-rate-tasks / Timo Feld." Ulm : Universität Ulm, 2020. http://d-nb.info/1203716273/34.

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11

Scannell, Paddy. "Broadcasting and time." Thesis, University of Westminster, 2006. https://westminsterresearch.westminster.ac.uk/item/9273v/broadcasting-and-time.

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This thesis brings together work I have published in the last five years in academic journals and edited book collections. All the material presented in the thesis, much of it substantially rewritten, will appear in the trilogy I have been working on since my last published book, Radio, Television and Modern Life (Blackwell 1996). The organising structure of the thesis and its substantive concerns corresponds with that of the three books that will come out of it. The form and content of the thesis, and its relation to the books, is discussed in some detail in its introduction. Its fundamental concern is with human time which I have explored in all my writings since I began research thirty years ago, with my late friend and colleague David Cardiff, into the early history of the British Broadcasting Corporation. The medium of radio is time. Historiography deals with past time. The academic work of writing history on the other, and the temporality of radio and television on the one hand, are the first two themes of this thesis which shows that the orders of time in which they work are divergent rather than convergent. The third section of the thesis attempts their reconciliation through the recovery of meaningful time.
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12

Schlüter, Tim [Verfasser], Stefan [Akademischer Betreuer] Conrad, and Frank [Akademischer Betreuer] Gurski. "Knowledge Discovery from Time Series / Tim Schlüter. Gutachter: Stefan Conrad ; Frank Gurski." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2012. http://d-nb.info/102219562X/34.

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13

Kriebel, Maximilian [Verfasser], Tim [Akademischer Betreuer] Clark, Tim [Gutachter] Clark, and Rainer [Gutachter] Fink. "1. Feynman-dispersion correction 2. Charge transport via imaginary time propagation / Maximilian Kriebel ; Gutachter: Tim Clark, Rainer Fink ; Betreuer: Tim Clark." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1211557510/34.

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14

Kerstan, Timo Verfasser], Franz Josef [Akademischer Betreuer] [Rammig, and Marco [Akademischer Betreuer] Platzner. "Towards full virtualization of embedded real-time systems / Timo Kerstan. Betreuer: Franz J. Rammig ; Marco Platzner." Paderborn : Universitätsbibliothek, 2011. http://d-nb.info/1033763748/34.

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15

Hadfield, Mitchell Gregory. "Analysis of Performance Measures of Traffic Incident Management in Utah." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8529.

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In 2009 the Federal Highway Administration published a report regarding a Focus States Initiative that had been conducted with 11 states to discuss the development of national Traffic Incident Management (TIM) standards. Performance measures were defined, and a national TIM dashboard created, but very little data has been added to the dashboard since. In this research study, performance measures of the Utah Department of Transportation (UDOT) TIM program were analyzed. Data availability was first assessed to determine whether these performance measures could be calculated. It was determined that crash response data available from the Utah Highway Patrol (UHP) could be used to calculate the performance measures of Incident Management Teams (IMT) and UHP units; however, roadway clearance data were missing. UHP personnel agreed to collect additional data regarding crash roadway clearance for six months of the study. Performance measures of response time (RT), roadway clearance time (RCT), and incident clearance time (ICT) were calculated for responding units at 168 crashes. Using the crash response data from UHP and traffic speed, travel time, and volume data from UDOT databases, 83 of the 163 crashes that met additional criteria were evaluated to determine the volume of traffic affected (AV) by each incident and the associated user cost (EUC). Statistical analyses to determine relationships between different measures such as RT, RCT, ICT, AV, and EUC were conducted to assist UDOT in optimizing the allocation of their IMT resources.
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16

Wolz, Tim [Verfasser], and M. [Akademischer Betreuer] Weides. "Controlling Cavity Magnon Polariton Properties in Frequency and Time Domain / Tim Wolz ; Betreuer: M. Weides." Karlsruhe : KIT-Bibliothek, 2021. http://d-nb.info/1235072339/34.

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17

Süß, Tim [Verfasser], and auf der Heide Friedhelm [Akademischer Betreuer] Meyer. "Parallel real-time rendering using heterogeneous PC clusters / Tim Süß. Betreuer: Friedhelm Meyer auf der Heide." Paderborn : Universitätsbibliothek, 2011. http://d-nb.info/1036510972/34.

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18

Bennett, Logan Stewart. "Analysis of Benefits of an Expansion to UDOT's Incident Management Program." BYU ScholarsArchive, 2021. https://scholarsarchive.byu.edu/etd/9250.

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In 2018 the Utah Department of Transportation (UDOT) funded a study in which data were collected to evaluate performance measures for UDOT's Incident Management Team (IMT) program. After that study was completed, UDOT received funding to expand the size of its IMT program. Additionally, TransSuite, a data source used by the UDOT Traffic Operations Center to log incident-related data, was reconfigured to provide a higher quantity of performance measure data. This study made use of the new data source, in addition to Computer Aided Dispatch logs provided by the Utah Highway Patrol that were used in the first study, to collect performance measure data of the expanded program and measure the impacts of the IMT program expansion. Using these two datasets, a reanalyzed 2018 dataset and a new 2020 dataset, a comparison of performance measures was made. Performance measures studied included those defined as important by the Federal Highway Administration's Focus States Initiative in 2009, namely Roadway Clearance Time, Incident Clearance Time, and Response Time. These performance measures were calculated for IMT responders at 320 incidents in 2018 and 289 incidents in 2020. In addition, data regarding the affected volume associated with incidents, the excess travel time accumulated due to incidents, and the excess user cost associated with incident congestion were gathered. In 2018, 188 incidents were analyzed for these user impacts, and in 2020 144 incidents were analyzed. Statistical analyses were conducted to compare IMT performance between the two years and to determine relationships between performance measures and user impacts. The effects of the COVID-19 pandemic affected traffic volumes during this study, and statistical analyses were adjusted to account for volume differences between the two years. Results indicated that the expansion of the IMT program has allowed UDOT to respond faster to incidents, and respond to a larger quantity of incidents over a larger coverage area and in extended operating hours. Performance of the expanded IMT program has had significant effects in reducing incident-related congestion and its costs.
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19

Ruhlandt, Aike [Verfasser], Tim [Akademischer Betreuer] Salditt, Tim [Gutachter] Salditt, Jörg [Gutachter] Enderlein, Claus [Gutachter] Ropers, Alexander [Gutachter] Egner, Sarah [Gutachter] Köster, and Rainer [Gutachter] Kree. "Time-resolved X-ray phase-contrast tomography / Aike Ruhlandt ; Gutachter: Tim Salditt, Jörg Enderlein, Claus Ropers, Alexander Egner, Sarah Köster, Rainer Kree ; Betreuer: Tim Salditt." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://d-nb.info/1161942084/34.

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20

Ruhlandt, Aike Verfasser], Tim [Akademischer Betreuer] Salditt, Tim [Gutachter] Salditt, Jörg [Gutachter] Enderlein, Claus [Gutachter] Ropers, Alexander [Gutachter] [Egner, Sarah [Gutachter] Köster, and Rainer [Gutachter] Kree. "Time-resolved X-ray phase-contrast tomography / Aike Ruhlandt ; Gutachter: Tim Salditt, Jörg Enderlein, Claus Ropers, Alexander Egner, Sarah Köster, Rainer Kree ; Betreuer: Tim Salditt." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://d-nb.info/1161942084/34.

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21

Laitenberger, Oskar [Verfasser], Alexander [Akademischer Betreuer] Egner, Alexander [Gutachter] Egner, and Tim [Gutachter] Salditt. "Statistical analysis methods for time varying nanoscale imaging problems / Oskar Laitenberger ; Gutachter: Alexander Egner, Tim Salditt ; Betreuer: Alexander Egner." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1182033563/34.

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22

CALAZANS, DIEGO JOSE DE. "TIME OR NON-TIME?: A STUDY ABOUT THE EXPERIENCE OF TIME AND THE NON-TIME OF THE EXPERIENCE." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2007. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=10314@1.

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COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
Este é um estudo acerca da natureza ontológica do tempo, ou seja, um estudo que visa distinguir, no âmbito da experiência, o tempo subjetivo do tempo em si mesmo, tentando delimitá-los por critérios de necessidade lógica e adequação formal as criticas e descobertas da filosofia e da ciência moderna e contemporânea. O trabalho consta também de um apanhado historiográfico das principais abstrações da ciência, bem como, das principais contribuições de filósofos, como, p.ex., Santo Agostinho e Kant, para a questão do tempo, abarcando também as criticas da física contemporânea ao paradigma clássico do tempo e as novas tendências de abordagem e pesquisa da questão do tempo no século XXI.
This is an essay on the ontologic nature of time, so to say, a study that intends to distinguish, inside the realm of experience, the subjective time from time itself, trying to bound both of them by logical necessity and formal adequation to the critics and discoveries from modern and contemporary philosophy and science. This essay also provides an historiographic resume of the main abstractions from sciense, as well as, the main contributions from philosophers, like Saint Augustine and Kant, for example, to the problem of time, approaching also the critics of contemporay physics to the classical time paradigm and the new trends of approach and research of time in the XXI century.
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23

Drevensek, Stéphanie. "Caractérisation de nouveaux constituants du cytosquelette chez Arabidopsis thaliana : les protéines TON et leurs partenaires." Paris 11, 2007. http://www.theses.fr/2007PA112069.

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Le cytosquelette des cellules végétales orchestre de nombreux processus de croissance, morphogenèse et différenciation. L’analyse de mutants chez Arabidopsis thaliana a permis l’isolement de nouvelles protéines et de leurs partenaires et de mieux comprendre les mécanismes gouvernant la dynamique des microtubules (MTs) et des microfilaments (MFs). Les mutants tonneau et fass présentent d’importants défauts morphologiques associés à une désorganisation des MTs corticaux. La protéine TON est conservée chez les plantes, et présente des homologies avec deux protéines centrosomales humaines. Nous avons montré que la fusion TON-GFP est associée aux MTs corticaux. Un crible 2-hybride avait permis d'isoler des partenaires de TON : une centrine et onze protéines inconnues, spécifiques des plantes, partageant cinq motifs conservés, et nommées TIM (TON Interactif Motif). Certains de ces motifs sont conservés chez une protéine centrosomale. La famille TIM compte une trentaine de membres dans le génome d’Arabidopsis. De façon surprenante, la fusion GFP-TIM1 se lie aux MTs et/ou aux MFs et nous avons pu identifier le domaine de liaison aux MTs. Nous avons isolé des simples, doubles et quadruple mutants d’une sous-famille de 4 protéines (TIM1 à TIM4) et montré que ces protéines sont importantes pour le développement de la plante. L'ensemble de ces résultats suggère que les protéines TON et TIM1 sont impliquées dans la dynamique des MTs corticaux et dans le développement de la plante. TIM1 pourrait également coordonner les réseaux de MTs et de MFs. La famille TIM pourrait se révéler essentielle dans l'organisation spatiale des structures corticales de cytosquelette végétal
The plant cell cytoskeleton is involved in many growth processes, morphogenesis and differentiation. Analysis of Arabidopsis thaliana mutants allowed us to uncover new proteins and their partners, and to better understand mechanisms that govern microtubules (MT) and microfilaments (MF) dynamics. The tonneau and fass mutants show considerable morphologic alterations associated with abnormalities in organization of cortical MTs. TON protein is strongly conserved in plants, and has similarities with two human centrosomal proteins. We have shown that a GFP-TON fusion is associated to the cortical cytoskeleton. A yeast 2-hybrid screen had previously lead to isolation of TON partners: a centrin and of 12 large unknown proteins, specific to plants, sharing 5 conserved motifs and named TIM (TON Interaction Motif). We showed that some of these motifs are conserved in CAP350, a centrosomal protein. The TIM family comprises about 30 members in the Arabidopsis genome. Interestingly, a GFP-TIM1 fusion binds both MTs and/or MFs. We have identified the TIM1 MT binding domain, which corresponds to a highly basic region. In order to study the role of these proteins in plant development, genetic study of one sub-family of 4 proteins (TIM1 to TIM4) has been undertaken. Phenotype analysis of single, double and quadruple mutants show significant defects in development. Taken together, results suggest an involvment of TON and TIM1 proteins in the dynamics of cortical MTs and in plant development. TIM1 could also coordiantes the MT and MF networks during the cell cycle. The TIM family could be essential for spatial organization of plant cortical cytoskeleton structures
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Lam, Vai Iam. "Time domain approach in time series analysis." Thesis, University of Macau, 2000. http://umaclib3.umac.mo/record=b1446633.

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25

Banachowski, Scott. "CPU time-sharing in real-time systems /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2005. http://uclibs.org/PID/11984.

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26

Milton, Robert. "Time-series in distributed real-time databases." Thesis, University of Skövde, Department of Computer Science, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-827.

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In a distributed real-time environment where it is imperative to make correct decisions it is important to have all facts available to make the most accurate decision in a certain situation. An example of such an environment is an Unmanned Aerial Vehicle (UAV) system where several UAVs cooperate to carry out a certain task and the data recorded is analyzed after the completion of the mission. This project aims to define and implement a time series architecture for use together with a distributed real-time database for the ability to store temporal data. The result from this project is a time series (TS) architecture that uses DeeDS, a distributed real-time database, for storage. The TS architecture is used by an application modelled from a UAV scenario for storing temporal data. The temporal data is produced by a simulator. The TS architecture solves the problem of storing temporal data for applications using DeeDS. The TS architecture is also useful as a foundation for integrating time series in DeeDS since it is designed for space efficiency and real-time requirements.

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27

Chetthamrongchai, Paitoon. "Time orientation and time use in shopping." Thesis, University of Manchester, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496483.

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Previous work on shopping behaviour can be catergorised into three themes. Work has been done to identify different motivations for shopping, developing the original thinking of Stone, (1954) and Tauber, (1972). Work has been done on retail patronage, examining shopping behaviour from the image promoted by retailers, building upon the original work of Matineau, (1958) and Lindquist, (1974). A third body of work, somewhat less coherent, contains a collection of different models of patronage, the most relevant here being that concerned with retail location, based on the work of Huff, (1964) and Christall and Loch, (1930) where patronage is seen to decline with distance. This thesis draws mainly from the perspective in the first theme. It takes as its starting point the concept of the individual being an allocator of time as well as money. People are seen as being motivated in their allocation of time to activities such as shopping by their time orientation. This in tum creates different attitudes to shopping which influences shopping behaviour. Previous work on time attitude and shopping behaviour has tended to emphasise solely time pressure and time saving as being linked (Berry, 1979), although others have seen time orientation as more complex (Gronmo, 1989 and Graham, 1981). A framework is developed that links attitude to time to attitude to shopping and then to actual shopping behaviour. The main contribution from the thesis is in the development and testing ofthis framework. 12 Attitudes to time are claimed to be culture specific (Graham, 1981 and Sheth and Hirshman, 1987) and so the framework is tested in two countries, Britain and Thailand. A questionnaire was developed to measure time attitude, shopping attitude and shopping behaviour in the context of food shopping. This was applied in Blackburn and Bangkok. Factor analysis is used to identify time and shopping attitudes. These are correlated with shopping behaviour specifically time spent shopping, shopping frequency, time of the day used for shopping and the patronage of individual outlets. Cluster analysis is used based upon the time and shopping factors to identify four market segments in each country. Comparisons are made between the results from each study. Although the results contain certain similarities, there are also significant differences that may be linked to differences in attitudes to time between the two countries. The main conclusion from the research is that the time perspective is useful in understanding consumer psychology and patronage behaviour. The results show that time orientation plays an important role in segmenting consumer markets. There are a number of theoretical and practical implications. The conceptualisation of time attitude being linked to patronage behaviour makes a significant contribution to marketing theory. The thesis shows that time orientation and shopping motivation are valuable dimensions in understanding consumer shopping behaviour.
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28

Scott, Mark Alan. "Time-to-time information in interceptive tasks." Thesis, Manchester Metropolitan University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264712.

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29

Leijon, Viktor. "A time constrained real-time process calculus /." Luleå : EISLAB, Department of Computer Science and Electrical Engineering, Luleå University of Technology, 2008. http://epubl.ltu.se/1402-1757/2008/33/.

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30

Rivera, Monica Alexandra. "Slowing Down Time, studies on spatial time." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/33992.

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The experience of time is not fixed by a rigid mathematical measure, instead, it flows at vaying rates. There are certain occasions in which we would like to extend time with all our force, up to the limit of our stretched arms and further. Conversely there are moments which we'd like to last no more that the sparkle of a flash, but as we all have noticed, those are the longest in our life. How does the space that we inhabit influence on our perception of time? May we identify especial elements that contribute in one or other sense to accelerate or slowdown the time? It's said that time and space is an inseparable unity, as two aspects of the same thing. If this is so, then it also must be true that by shaping space in one way or another, we might influence the experience of time through it. Wouldn't it be delightful to believe that we may be magicians of time through manipulation of architecture?
Master of Architecture
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31

Morrill, Jeffrey P., and Jonathan Delatizky. "REAL-TIME RECOGNITION OF TIME-SERIES PATTERNS." International Foundation for Telemetering, 1993. http://hdl.handle.net/10150/608854.

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International Telemetering Conference Proceedings / October 25-28, 1993 / Riviera Hotel and Convention Center, Las Vegas, Nevada
This paper describes a real-time implementation of the pattern recognition technology originally developed by BBN [Delatizky et al] for post-processing of time-sampled telemetry data. This makes it possible to monitor a data stream for a characteristic shape, such as an arrhythmic heartbeat or a step-response whose overshoot is unacceptably large. Once programmed to recognize patterns of interest, it generates a symbolic description of a time-series signal in intuitive, object-oriented terms. The basic technique is to decompose the signal into a hierarchy of simpler components using rules of grammar, analogous to the process of decomposing a sentence into phrases and words. This paper describes the basic technique used for pattern recognition of time-series signals and the problems that must be solved to apply the techniques in real time. We present experimental results for an unoptimized prototype demonstrating that 4000 samples per second can be handled easily on conventional hardware.
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32

Basali, Timo [Verfasser], and Nicole [Gutachter] Schupp. "Untersuchung der Nierenschädigung durch Aldosteron am Rattenmodell über die Quantifizierung von Schädigungsmarkern mittels Real-Time PCR-Technik / Timo Basali ; Gutachter: Nicole Schupp." Würzburg : Universität Würzburg, 2017. http://d-nb.info/1137835982/34.

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33

Mai, Timo [Verfasser], Robert [Akademischer Betreuer] Weigel, Robert [Gutachter] Weigel, and Ralf [Gutachter] Brederlow. "A Real-Time Capable and Configurable Analog Front-End for SAR-ADCs / Timo Mai ; Gutachter: Robert Weigel, Ralf Brederlow ; Betreuer: Robert Weigel." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2021. http://d-nb.info/1233010557/34.

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34

Fricke, Tim [Verfasser], Florian [Akademischer Betreuer] [Gutachter] Holzapfel, and Klaus [Gutachter] Bengler. "Flight Control with Large Time Delays and Reduced Sensory Feedback / Tim Fricke ; Gutachter: Klaus Bengler, Florian Holzapfel ; Betreuer: Florian Holzapfel." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1134865821/34.

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Richter-Heitmann, Tim [Verfasser], Michael W. [Akademischer Betreuer] [Gutachter] Friedrich, and Martin [Gutachter] Diekmann. "(Acido)bacterial diversity in space and time / Tim Richter-Heitmann ; Gutachter: Michael W. Friedrich, Martin Diekmann ; Betreuer: Michael W. Friedrich." Bremen : Staats- und Universitätsbibliothek Bremen, 2016. http://d-nb.info/1123194807/34.

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36

Medhurst, Pamela Wendy. "Part-time study, full-time lives : stories of success from part-time undergraduate students." Thesis, University of Hull, 2008. http://hydra.hull.ac.uk/resources/hull:1748.

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This thesis is concerned with part-time undergraduate students within the higher education system in England. In particular it focusses on the strategies this group of students employ to complete their degrees successfully. I place the experience of successful part-time students at the heart of the thesis because I think that it is vital in the twenty-first century to further our understanding of this heterogeneous group in order to have an accessible higher education system that does not by design discriminate against those who choose a particular mode of study. By doing this I create a collective narrative for part-time students. A small qualitative sample of completed part-time undergraduate students was interviewed to produce the data used herein.
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37

Wegner, Maus Victor, Gilberto Camara, Marius Appel, and Edzer Pebesma. "dtwSat: Time-Weighted Dynamic Time Warping for Satellite Image Time Series Analysis in R." Foundation for Open Access Statistics, 2019. http://epub.wu.ac.at/6808/1/v88i05.pdf.

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The opening of large archives of satellite data such as LANDSAT, MODIS and the SENTINELs has given researchers unprecedented access to data, allowing them to better quantify and understand local and global land change. The need to analyze such large data sets has led to the development of automated and semi-automated methods for satellite image time series analysis. However, few of the proposed methods for remote sensing time series analysis are available as open source software. In this paper we present the R package dtwSat. This package provides an implementation of the time-weighted dynamic time warping method for land cover mapping using sequence of multi-band satellite images. Methods based on dynamic time warping are flexible to handle irregular sampling and out-of-phase time series, and they have achieved significant results in time series analysis. Package dtwSat is available from the Comprehensive R Archive Network (CRAN) and contributes to making methods for satellite time series analysis available to a larger audience. The package supports the full cycle of land cover classification using image time series, ranging from selecting temporal patterns to visualizing and assessing the results.
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38

Swan, Paul, and Linda Marshall. "Mathematics games: Time wasters or time well spent?" Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-80997.

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Globally education authorities are placing increasing emphasis on the development of literacy and numeracy in primary schools. This paper reports on research designed to assist teachers to improve the numeracy of their students by making the use of mathematics games a more focused aspect of the teaching and learning experience in mathematics. Classroom experience and anecdotal evidence suggest that games are often used without really focussing on the mathematics involved in playing the game,and are justified simply on the basis of children having ‘fun’. In this paper we report on the use of one game, Numero and how teachers made use of the game and the impact on the children’s learning when using the game.
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39

Jerbi, Ali. "Adaptive control of time-varying discrete-time systems." Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/15743.

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40

Zhou, Yongjun. "Execution time analysis for dynamic real-time systems." Ohio : Ohio University, 2002. http://www.ohiolink.edu/etd/view.cgi?ohiou1175011592.

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41

Mathis, Neil W. "Inside of an outside in time time| Thoughtitarium." Thesis, California State University, Long Beach, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1603757.

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Since the Devonian Period, 360 million years ago, trees have been foundational for the survival of aerobic life. Today, most humans relate to trees through the idea, material and commodity of wood. This understanding is primarily informed by its use as a building material: the formal attributes of its grain pattern read to assess structural integrity and aesthetic applications. I think of these marks as autonomous and unique natural drawings, documenting time in a scale different from our lifespan. Wood’s composition of cellulose and lignin create patterns that record temporal fluctuations in precipitation and the unique soil compounds of each tree’s growth site as a codex. As an MFA candidate, I used woodworking techniques to explore the relationship between temporality and materiality. Along the way, I became interested in the reductive carving techniques of woodturning as a metaphor for this investigation: cutting through layers of time. Small segments of wood were laminated together in mathematical patterns and turned to reveal parabolic grids on the interior and exterior surface of each object. This study led me to consider the limitations that traditional art display conventions impose on the viewer’s perception of an artwork, and to the realization of the Thoughtitarium; an eight-foot diameter fiberglass hemisphere that hovered above the gallery floor in architectural scale.

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42

Tauchert, Ashley. "Mary Wollstonecraft in her time and our time." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264200.

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43

Xu, Mengyuan Tracy. "Filtering non-stationary time series by time deformation." Ann Arbor, Mich. : ProQuest, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3309151.

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Thesis (Ph.D. in Statistical Science)--S.M.U.
Title from PDF title page (viewed Mar. 16, 2009). Source: Dissertation Abstracts International, Volume: 69-04, Section: B, page: 2402. Advisers: Wayne A. Woodward; Henry L. Gray. Includes bibliographical references.
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44

Cuevas, Tello Juan Carlos. "Estimating time delays between irregularly sampled time series." Thesis, University of Birmingham, 2007. http://etheses.bham.ac.uk//id/eprint/88/.

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The time delay estimation between time series is a real-world problem in gravitational lensing, an area of astrophysics. Lensing is the most direct method of measuring the distribution of matter, which is often dark, and the accurate measurement of time delays set the scale to measure distances over cosmological scales. For our purposes, this means that we have to estimate a time delay between two or more noisy and irregularly sampled time series. Estimations have been made using statistical methods in the astrophysics literature, such as interpolation, dispersion analysis, discrete correlation function, Gaussian processes and Bayesian method, among others. Instead, this thesis proposes a kernel-based approach to estimating the time delay, which is inspired by kernel methods in the context of statistical and machine learning. Moreover, our methodology is evolved to perform model selection, regularisation and time delay estimation globally and simultaneously. Experimental results show that this approach is one of the most accurate methods for gaps (missing data) and distinct noise levels. Results on artificial and real data are shown.
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45

Suwansantisuk, Watcharapan 1978. "First-passage-time problems in time-aware networks." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/75651.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 183-194).
First passage time or the first time that a stochastic process crosses a boundary is a random variable whose probability distribution is sought in engineering, statistics, finance, and other disciplines. The probability distribution of the first passage time has practical utility but is difficult to obtain because the values of the stochastic process at different times often constitute dependent random variables. As a result, most first-passage-time problems are still open and few of them are explicitly solved. In this thesis, we solve a large class of first-passage-time problems and demonstrate the applications of our solutions to networks that need to maintain common-time references. Motivated by rich applications of first passage time, we solve first-passage-time problems, which are divided into four categories according to the form of stochastic processes and the type of the boundaries. The four categories cover Brownian motion with quadratic drift and the boundary that consists of two constants; Brownian motion with polynomial drift of an arbitrary degree and the boundary that consists of two constants; multi-dimensional Brownian motion with polynomial drift and a class of boundaries that are characterized by open sets in the Euclidean space; and a discrete-time process with a class of correlations and the boundary that consists of one constant. These first-passage-time problems are challenging yet important for practical utility. The solutions to these first-passage-time problems range from an explicit expression to a bound of the first-passage-time distribution, reflecting the inherent difficulty in these first-passage-time problems. For Brownian motion with quadratic drift, the solution is explicit, consisting of elementary functions and functions that are characterized by Laplace transforms. For Brownian motion with polynomial drift of an arbitrary order, the solution involves analytical and numerical methods. For multi-dimensional Brownian motion, the solution is explicit for a certain shape of the boundary and is given by an upper bound and a lower bound for the other shapes. For the discrete-time process, the solution is explicit. The strength of our solutions is that they cover a large class of first-passage-time problems and are easy to use. The primary approach that allows us to solve these first-passage-time problems is transformation methodology. We apply various types of transformations, including transformation of probability measure, transformation of time, and integral transformation. Although these transformations are known, the combination of them in an appropriate order enables the solutions to previously-unsolved first-passage-time problems. We also discuss other problems that can be solved as consequences of the transformation methodology, including first-passage-time problems that involve a one-sided constant boundary, a moving boundary, and drifts such as logarithmic, exponential, sinusoidal, and square-root functions. A large class of first-passage-time problems confirms the utility of the transformation methodology. We demonstrate an application of the first-passage-time problems in the context of network synchronization. In the first setting that we consider, the first passage time is the first time that a network loses synchronization with a reference clock. At the first passage time, clocks in the network need to be calibrated. In the second setting, the first passage time represents the first time that a node achieves a correct synchronization of frames or packets. At the first passage time, a node in the network is able to process the packets that are transmitted as parts of the calibration. In both settings, we consider two performance metrics-the average and the outage-which succinctly summarize the first passage time. These metrics give insight, for example, into the amount of time for networks to lose synchronization as a function of key parameters such as noise in the clocks and the number of nodes in the network. Given the large class of first-passage-time problems being solved, we expect the thesis results to be useful in many disciplines where first-passage-time problems appear.
by Watcharapan Suwansantisuk.
Ph.D.
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46

Cheng, Haiqian 1975. "Time-to-collision algorithm and real-time implementation." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/80083.

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47

Hoerl, Christoph. "Keeping track of time : time, thought and memory." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320929.

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48

Ashfold, Thomas Edward. "Work, time and rhythm : investigating contemporary 'time squeeze'." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:c5fc9e00-fc82-4574-9099-3eb9d4e56bdb.

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In contemporary capitalist economies such as the UK, it is commonly held that an increasing number of people and households experience anxiety over time and symptoms of 'time squeeze'. Existing accounts of the character and causes of this phenomenon are rather one-dimensional and lacking in nuance, however. In part, this is because they typically lack any substantial theoretical engagement with the concept of time itself. Accordingly, this research aims to provide a more complex and contextual account of experiences of working time (both paid and unpaid), and to investigate how and why experiences of time squeeze vary between individuals and social groups. This is achieved by calling upon an enriched understanding of time, and employing an instrumental case study built around a set of 50 semi-structured interviews with employees working in Oxford University's central IT department and four of its constituent colleges. The empirical findings reveal that the (quantitative) extent and (qualitative) nature of participants' temporal anxieties vary with occupation, social class, gender, age and family status, as well as the importance of institutional and local context. Furthermore, they demonstrate that contemporary time squeeze is generated by a variety of causal mechanisms relating to the duration, tempo and timing of both paid employment and unpaid reproductive work, and their intersections with the personal, natural, social, institutional and technological rhythms that variously constitute everyday life.
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49

Suettmann, Melanie. "Time will tell : time perspective in bipolar disorder." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20464.

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Background: Time Perspective is an individual difference variable that is believed to underpin ‘virtually all aspects of human functioning’ (Boniwell & Zimbardo, 2010). Indeed, it has so far predicted a large variety of outcome variables in previous research, including behaviours, attitudes, values, habits and decision-making. However, it has never been tested as a predictor of mood, or in psychiatric disorders. Time perspective theory posits that a balanced time perspective is necessary for healthy functioning. Time Perspective biases, on the other hand, are believed to lead to maladaptive functioning. This thesis investigates whether time perspective does also underpin and predict the most extreme ends of the mood spectrum in bipolar disorder. Participants: Three online studies were conducted with two samples of adults with bipolar disorders and one sample of adults with no mental health diagnosis. Setting: All samples were collected online, from across the world. Objectives: A series of studies investigated various aspects of time perspective theory to establish the relationship between mood and time perspective. Ten research questions were designed to answer questions on time perspective’s ability to differentiate and predict mood, and to find out whether or not it functions differently in normal and abnormal mood. It was also established whether time perspective predicts mood states differentially. Methodology: Regression analyses, MANOVAs, ANOVA and t-tests were performed to answer the research questions. Results: Our time perspective profile does indeed appear to underpin bipolar mood states. All five time perspectives were able to differentiate between four bipolar mood states. When considered separately, the five time perspectives did appear to predict mood states differentially, i.e. different time perspectives were predictors for separate bipolar mood states. Moreover, time perspective does appear to function significantly different in adults with no mental health diagnosis. Conclusions: The results of this series of studies suggests that time perspective indeed also underpins mood and can differentiate between normal and abnormal bipolar mood states. Compared to impulsiveness and BIS/BAS sensitivity, time perspective was able to explain more variance in these samples when used as a predictor.
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50

Lopez-Castellanos, Victor. "Ultrawideband Time Domain Radar for Time Reversal Applications." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1301040987.

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