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Journal articles on the topic 'Time-kill kinetics'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Oladosu, P, Isu, et al. "Time kill-kinetics antibacterial study of Acacia nilotica." African Journal of Microbiology Research 7, no. 46 (2013): 5248–52. http://dx.doi.org/10.5897/ajmr2013.5889.

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Ferro, B. E., J. van Ingen, M. Wattenberg, D. van Soolingen, and J. W. Mouton. "Time-kill kinetics of antibiotics active against rapidly growing mycobacteria." Journal of Antimicrobial Chemotherapy 70, no. 3 (2014): 811–17. http://dx.doi.org/10.1093/jac/dku431.

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Andrew, Oche Emmanuel, Ebele U. Umeh, Isa Elabor, Suleiman Zakari, Edache Samuel, and Samuel Florence Anna. "Antibacterial Potential and Time-Kill Kinetics of Calotropis procera Extracts." UMYU Scientifica 3, no. 4 (2024): 459–68. https://doi.org/10.56919/usci.2434.040.

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Study’s Excerpt: The potentials of Calotropis procera extracts to combat antibiotic-resistant bacteria is assessed. Bioactive compounds like Lupenyl Acetate and Phytol in the plant showed antibacterial activity. The stem extract showed more antibacterial activity than the leaf. C procera could serve as a natural antibiotic alternative. Full Abstract: The escalating challenge of bacterial resistance to antibiotics has prompted interest in exploring the antibacterial potential of Calotropis procera. To investigate the antibacterial efficacy of C. procera, the leaves and stems of the plant were c

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Appiah, Theresa, Yaw Duah Boakye, and Christian Agyare. "Antimicrobial Activities and Time-Kill Kinetics of Extracts of Selected Ghanaian Mushrooms." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/4534350.

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The rapid rise of antimicrobial resistance is a worldwide problem. This has necessitated the need to search for new antimicrobial agents. Mushrooms are rich sources of potential antimicrobial agents. This study investigated the antimicrobial properties of methanol extracts of Trametes gibbosa, Trametes elegans, Schizophyllum commune, and Volvariella volvacea. Agar well diffusion, broth microdilution, and time-kill kinetic assays were used to determine the antimicrobial activity of the extracts against selected test organisms. Preliminary mycochemical screening revealed the presence of tannins,

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Basri, Dayang Fredalina, and Radhiah Khairon. "Pharmacodynamic Interaction ofQuercus infectoriaGalls Extract in Combination with Vancomycin against MRSA Using Microdilution Checkerboard and Time-Kill Assay." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/493156.

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The galls ofQuercus infectoriaOlivier possess astringent properties which helps in the tightening of the vaginal epithelium in the post-natal period. The present study aimed to observe the time-kill kinetics of the acetone and methanol extracts of gall ofQ. infectoriain combination with vancomycin against two methicillin-resistantStaphylococcus aureus(MRSA) strains; ATCC 33591 and MU 9495 (laboratory-passaged strain). Minimum inhibitory concentration (MIC) of the extracts were determined using microdilution technique whereas the checkerboard and time-kill kinetics were employed to verify the s

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Ferro, Beatriz E., Jakko van Ingen, Melanie Wattenberg, Dick van Soolingen, and Johan W. Mouton. "Time–kill kinetics of slowly growing mycobacteria common in pulmonary disease." Journal of Antimicrobial Chemotherapy 70, no. 10 (2015): 2838–43. http://dx.doi.org/10.1093/jac/dkv180.

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Arhin, Francis F., Geoffrey A. McKay, Sylvain Beaulieu, Ingrid Sarmiento, Thomas R. Parr, and Gregory Moeck. "Time–kill kinetics of oritavancin and comparator agents against Streptococcus pyogenes." International Journal of Antimicrobial Agents 34, no. 6 (2009): 550–54. http://dx.doi.org/10.1016/j.ijantimicag.2009.08.012.

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8

T, Subathra, Shanmugapriya P, Rajalakshmi K, Mary Shamya Arokiarajan, Ramamurthy M, and Meenakumari R. "EVALUATION OF ANTIMICROBIAL ACTIVITY AND TIME-KILL KINETICS OF CHITHIRAMOOLA KULIGAI AGAINST MICROBIAL PATHOGENS." International Journal of Research in Ayurveda and Pharmacy 15, no. 3 (2024): 104–10. http://dx.doi.org/10.7897/2277-4343.15380.

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The vaginal microbiota plays a crucial role in maintaining physiological homeostasis and protecting against pathogenic invasion. Dysbiosis, or imbalance in the vaginal microbiota, is associated with increased susceptibility to sexually transmitted infections like human papillomavirus, which is linked to cervical cancer. Traditional herbal medicine, such as "Chithiramoola Kuligai" (CMK), offers potential as an alternative therapeutic approach, yet its antimicrobial efficacy remains largely unexplored. This study aimed to comprehensively assess the antimicrobial activity of CMK against a range o

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Kyahar, Friday I., Edith A. Onwuliri, Joseph O. Ehinmidu, and Peters O. Oladosu. "Time-kill kinetics and antibacterial activity of root extract of Adenodolichos paniculatus (Hua) Hutch & Dalz (Fabaceae)." Journal of Pharmacy & Bioresources 18, no. 2 (2021): 95–102. http://dx.doi.org/10.4314/jpb.v18i2.2.

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Medicinal plants have been used in treatment of illness from time immemorial. Adenodolichos paniculatus is a medicinal plant used for traditional remedy of sore throat infections. This study therefore, evaluated the antibacterial activities of the root extracts and time-kill kinetics of the most potent extract. Five extracts, obtained by maceration using n-hexane, chloroform, ethyl acetate, methanol and water sequentially were evaluated for antibacterial activities and time-kill kinetics against Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. Chlorof

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Babaiwa, UF, SO Eraga, and JO Akerele. "Antimicrobial and time-kill kinetics of the aqueous extract of Citrullus lanatus (Thunb.) seeds." Bio-Research 18, no. 1 (2020): 1103–10. http://dx.doi.org/10.4314/br.v18i1.5.

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This study evaluated the antimicrobial property of the aqueous extract of Citrullus lanatus (watermelon) seeds and its concentration-effect relationship (time-kill studies) on typed bacterial and fungal strains. Crude powdered seeds of Citrullus lanatus were extracted by maceration with water. Antimicrobial assay of the aqueous extracts was determined against Bacillus subtilis (NCTC 8236), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 10145), Staphylococcus aureus (ATCC 25923), and Candida albicans (ATCC 24433) using standard microbiological methods. A total of 106 CFU/mL of each

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Göttig, Stephan, Denia Frank, Eleonora Mungo, et al. "Emergence of ceftazidime/avibactam resistance in KPC-3-producing Klebsiella pneumoniae in vivo." Journal of Antimicrobial Chemotherapy 74, no. 11 (2019): 3211–16. http://dx.doi.org/10.1093/jac/dkz330.

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Abstract Objectives The β-lactam/β-lactamase inhibitor combination ceftazidime/avibactam is active against KPC-producing Enterobacterales. Herein, we present molecular and phenotypic characterization of ceftazidime/avibactam resistance in KPC-3-producing Klebsiella pneumoniae that emerged in vivo and in vitro. Methods Sequence analysis of blaKPC-3 was performed from clinical and in vitro-generated ceftazidime/avibactam-resistant K. pneumoniae isolates. Time–kill kinetics and the Galleria mellonella infection model were applied to evaluate the activity of ceftazidime/avibactam and imipenem alon

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Al-Lahham, Adnan, and Ralf René Reinert. "Time-Kill Kinetics of Streptococcus pneumoniae with Reduced Susceptibility to Telithromycin." Chemotherapy 53, no. 3 (2007): 190–93. http://dx.doi.org/10.1159/000100517.

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Balogun, Olasinbo Olumuyiwa, Sylvanus Chukwudi Ugoh, Olabisi Peter Abioye, and Peters Oluwale Oladosu. "Time-kill kinetics antibacterial activity of ethyl acetate extract of Bacillus subtilis subsp. subtilis 168." Journal of Phytomedicine and Therapeutics 24, no. 1 (2025): 1779–94. https://doi.org/10.4314/jopat.v24i1.5.

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The rise of antibiotic-resistant pathogens underscores the urgent need to fortify existing antimicrobials. Novel antibiotics are products of microbes, as two-thirds of the currently available antibiotics are sourced from them. Understanding the killing rate of the potential antibiotic-producing microbes is essential for the development stage of effective antimicrobials. Our preliminary investigation identified a potential antibiotic-producing Bacillus subtilis subsp. subtilis 168. This study investigated the inhibitory activity and time-kill kinetics ofextract of the candidate isolate against

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Akinduti, P. A., A. Oluwadun, J. A. O. Olugbuyiro, et al. "Antimicrobial activity and time kill kinetics of Nigerian Honeys on multi-resistant Enteric Bacilli." IOP Conference Series: Earth and Environmental Science 210 (December 6, 2018): 012003. http://dx.doi.org/10.1088/1755-1315/210/1/012003.

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Dubeni, Z. B., B. Mayekiso, V. Muchenje, and J. Muphangwa. "Antibacterial activity and time-kill kinetics study of Moringa oleifera Lam. crude leaf extracts." South African Journal of Botany 115 (March 2018): 284. http://dx.doi.org/10.1016/j.sajb.2018.02.033.

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Boswell, F. J., J. M. Andrews, and R. Wise. "Pharmacodynamic properties of faropenem demonstrated by studies of time- kill kinetics and postantibiotic effect." Journal of Antimicrobial Chemotherapy 39, no. 3 (1997): 415–18. http://dx.doi.org/10.1093/jac/39.3.415.

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Alayande, Kazeem Adekunle, Carolina H. Pohl, and Anofi Omotayo Tom Ashafa. "Time-kill kinetics and biocidal effect of Euclea crispa leaf extracts against microbial membrane." Asian Pacific Journal of Tropical Medicine 10, no. 4 (2017): 390–99. http://dx.doi.org/10.1016/j.apjtm.2017.03.022.

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18

Odeyemi, O., and I. B. Enweani-Nwokelo. "Anti-dermatophytic activities and time-kill kinetics of the methanol extracts of Napoleona imperialis." African Journal of Clinical and Experimental Microbiology 26, no. 1 (2024): 81–93. https://doi.org/10.4314/ajcem.v26i1.10.

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Background: Dermatophytosis is one of the most common cutaneous infections in the world. This is a superficial fungal infection that pose public health challenges to man and animals. The objective of this study is to evaluate the anti-dermatophytic activities of the different parts of Napoleona imperialis extract against selected clinical dermatophytes isolated from school children in Anambra State, Nigeria.Methodology: The pulverized materials of the authenticated plant parts were extracted using cold maceration method for 48 hours in methanol. Stock solutions of the extracts were prepared by

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Lee, A. A., M. J. Senior, M. I. Wallace, T. E. Woolley, and I. M. Griffiths. "Dissecting the self-assembly kinetics of multimeric pore-forming toxins." Journal of The Royal Society Interface 13, no. 114 (2016): 20150762. http://dx.doi.org/10.1098/rsif.2015.0762.

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Pore-forming toxins are ubiquitous cytotoxins that are exploited by both bacteria and the immune response of eukaryotes. These toxins kill cells by assembling large multimeric pores on the cell membrane. However, a quantitative understanding of the mechanism and kinetics of this self-assembly process is lacking. We propose an analytically solvable kinetic model for stepwise, reversible oligomerization. In biologically relevant limits, we obtain simple algebraic expressions for the rate of pore formation, as well as for the concentration of pores as a function of time. Quantitative agreement is

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Cantón, Emilia, Javier Pemán, Miguel Gobernado, Angel Viudes, and Ana Espinel-Ingroff. "Patterns of Amphotericin B Killing Kinetics against Seven Candida Species." Antimicrobial Agents and Chemotherapy 48, no. 7 (2004): 2477–82. http://dx.doi.org/10.1128/aac.48.7.2477-2482.2004.

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ABSTRACT In a previous study tolerance to amphotericin B (AMB) was found among Candida parapsilosis and C. dubliniensis strains by seeding the whole volumes of wells used for MIC determinations, and minimum fungicidal concentrations (MFC) for non-C. albicans Candida strains were demonstrated to be above the levels safely achievable in serum. As an extension of that study, we performed time-kill assays with 26 blood culture isolates (6 C. albicans, 5 C. parapsilosis, 5 C. krusei, 4 C. glabrata, 3 C. lusitaniae, and 3 C. tropicalis isolates), 3 oropharyngeal C. dubliniensis isolates, 3 AMB-susce

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Sacha, Jonah B., Matthew B. Buechler, Laura P. Newman, et al. "Simian Immunodeficiency Virus-Specific CD8+ T Cells Recognize Vpr- and Rev-Derived Epitopes Early after Infection." Journal of Virology 84, no. 20 (2010): 10907–12. http://dx.doi.org/10.1128/jvi.01357-10.

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ABSTRACT The kinetics of CD8+ T cell epitope presentation contribute to the antiviral efficacy of these cells yet remain poorly defined. Here, we demonstrate presentation of virion-derived Vpr peptide epitopes early after viral penetration and prior to presentation of Vif-derived epitopes, which required de novo Vif synthesis. Two Rev epitopes exhibited differential presentation kinetics, with one Rev epitope presented within 1 h of infection. We also demonstrate that cytolytic activity mirrors the recognition kinetics of infected cells. These studies show for the first time that Vpr- and Rev-

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Sieberi, Berick Moturi, George Isanda Omwenga, Rachael Kitondo Wambua, Judith Chemutai Samoei, and Mathew Piero Ngugi. "Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtilis, and Staphylococcus aureus." Scientific World Journal 2020 (July 1, 2020): 1–8. http://dx.doi.org/10.1155/2020/6378712.

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Bacterial infections are responsible for a large number of deaths every year worldwide. On average, 80% of the African population cannot afford conventional drugs. Moreover, many synthetic antibiotics are associated with side effects and progressive increase in antimicrobial resistance. Currently, there is growing interest in discovering new antibacterial agents from ethnomedicinal plants. About 60% of the population living in developing countries depends on herbal drugs for healthcare needs. This study involved the screening of Centella asiatica commonly used by herbal medicine practitioners

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Miner, Norman, Valerie Harris, Sara Stumph, Amanda Cobb, and Jennifer Ortiz. "Studies of Polyester Fiber as Carrier for Microbes in a Quantitative Test Method for Disinfectants." Journal of AOAC INTERNATIONAL 87, no. 2 (2004): 429–34. http://dx.doi.org/10.1093/jaoac/87.2.429.

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Abstract Tests were conducted by a Task Force on Disinfectant Test Methods that was appointed to investigate controversies regarding the accuracy of AOAC test methods for disinfectants as presented in AOAC's Official Methods of Analysis, Chapter 6. The general principles for new and improved AOAC tests are discussed, and a disinfectant test using microbes labeled onto a polyester fiber surface is described. The quantitative test measures the survival of test microbes as a function of exposure time as well as the exposure conditions required to kill 6 log10 of the test microbes. The time requir

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Locke, Jeffrey B., Amanda L. Almaguer, Joanna L. Donatelli, and Ken F. Bartizal. "Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-ResistantCandida albicansand Non-albicans CandidaSpecies." Infectious Diseases in Obstetrics and Gynecology 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/7040498.

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Background.While echinocandins demonstrate excellent efficacy againstCandidaspecies in disseminated infections and demonstrate potent minimal inhibitory concentration (MIC) values under standard susceptibility testing conditions, investigation under conditions relevant to the vaginal environment was needed. We assessed the antifungal activity and time-kill kinetics of the novel echinocandin rezafungin (formerly CD101) under such conditions, againstCandidaspecies relevant to vulvovaginal candidiasis (VVC).Methods. Susceptibility testing of fluconazole-susceptible and fluconazole-resistantC. alb

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Techaoei, Surachai. "Time-kill kinetics and antimicrobial activities of Thai medical plant extracts against fish pathogenic bacteria." Journal of Advanced Pharmaceutical Technology & Research 13, no. 1 (2022): 25. http://dx.doi.org/10.4103/japtr.japtr_241_21.

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Di Pilato, Vincenzo, Federica Ceccherini, Samanta Sennati, et al. "In vitro time-kill kinetics of dalbavancin against Staphylococcus spp. biofilms over prolonged exposure times." Diagnostic Microbiology and Infectious Disease 96, no. 2 (2020): 114901. http://dx.doi.org/10.1016/j.diagmicrobio.2019.114901.

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Skinner, Kirsty, Stephen Birchall, David Corbett, Pia Thommes, and Hans H. Locher. "Time-kill kinetics of cadazolid and comparator antibacterial agents against different ribotypes of Clostridium difficile." Journal of Medical Microbiology 67, no. 9 (2018): 1402–9. http://dx.doi.org/10.1099/jmm.0.000808.

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Akinjogunla, O. J., A. N. Umo, M. F. Alozie, G. O. Oshosanya, and G. I. Saturday. "Antibacterial activity and time kill kinetics of Amlodipine, Thioridazine and Promethazine against pathogenic clinical bacterial isolates." African Journal of Clinical and Experimental Microbiology 22, no. 3 (2021): 397–406. http://dx.doi.org/10.4314/ajcem.v22i3.11.

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Background: The emergence of multi-drug resistant bacterial strains worldwide has necessitated the scientific search for novel, potent, and affordable antimicrobial agents including medicinal plants and non-antibiotic drugs for therapy of infectious diseases. The objective of this study is to assess in vitro antibacterial activities and time kill kinetics of some non-antibiotic drugs against pathogenic clinical bacterial isolates.Methodology: In vitro antibacterial activities including minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time kill kinetics of Am

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Adusei, Emmanuel B. A., Reimmel K. Adosraku, James Oppong-Kyekyeku, Cedric D. K. Amengor, and Yakubu Jibira. "Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn." Journal of Tropical Medicine 2019 (November 26, 2019): 1–8. http://dx.doi.org/10.1155/2019/1250645.

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Antimicrobial resistance (AMR) is a threat to the prevention and treatment of the increasing range of infectious diseases. There is therefore the need for renewed efforts into antimicrobial discovery and development to combat the menace. The antimicrobial activity of plumbagin isolated from roots of Plumbago zeylanica against selected organisms was evaluated for resistance modulation antimicrobial assay, time-kill kinetics assay, and inhibition of biofilm formation. The minimum inhibitory concentrations (MICs) of plumbagin and standard drugs were determined via the broth microdilution method t

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Pham, Thuy Anh Vu. "Comparison of Antimicrobial Activity against Porphyromonas gingivalis between Advanced Platelet-Rich Fibrin and Injectable Platelet-Rich Fibrin." International Journal of Biomaterials 2023 (March 27, 2023): 1–7. http://dx.doi.org/10.1155/2023/9194868.

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Platelet-rich fibrin (PRF) obtained via low-speed centrifugation has antimicrobial properties. This study was conducted to evaluate the effectiveness of advanced platelet-rich fibrin plus (A-PRF+) and injectable platelet-rich fibrin (I-PRF), obtained from patients with different periodontal states, against Porphyromonas gingivalis. A-PRF+ and I-PRF samples were obtained from venous blood of 60 subjects divided equally into three groups: periodontitis, gingivitis, and healthy gingiva groups. The antibacterial experiments evaluated biofilm inhibition, mature biofilm impact, and time-kill kinetic

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Hoellman, Dianne B., Melissa A. Visalli, Michael R. Jacobs та Peter C. Appelbaum. "Activities and Time-Kill Studies of Selected Penicillins, β-Lactamase Inhibitor Combinations, and Glycopeptides against Enterococcus faecalis". Antimicrobial Agents and Chemotherapy 42, № 4 (1998): 857–61. http://dx.doi.org/10.1128/aac.42.4.857.

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ABSTRACT The activities of piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin, ampicillin-sulbactam, vancomycin, and teicoplanin were tested against 212 Enterococcus faecalis strains (9 β-lactamase producers) by standard agar dilution MIC testing (104 CFU/spot). The MICs at which 50 and 90% of the isolates were inhibited (MIC50s and MIC90s, respectively) were as follows (μg/ml): piperacillin, 4 and 8; piperacillin-tazobactam, 4 and 8; ticarcillin, 64 and 128; ticarcillin-clavulanate, 64 and 128; ampicillin, 2 and 2; ampicillin-sulbactam, 1 and 2; vancomycin

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Nielsen, Elisabet I., Otto Cars, and Lena E. Friberg. "PredictingIn VitroAntibacterial Efficacy across Experimental Designs with a Semimechanistic Pharmacokinetic-Pharmacodynamic Model." Antimicrobial Agents and Chemotherapy 55, no. 4 (2011): 1571–79. http://dx.doi.org/10.1128/aac.01286-10.

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ABSTRACTWe have previously described a general semimechanistic pharmacokinetic-pharmacodynamic (PKPD) model that successfully characterized the time course of antibacterial effects seen in bacterial cultures when exposed to static concentrations of five antibacterial agents of different classes. In this PKPD model, the total bacterial population was divided into two subpopulations, one growing drug-susceptible population and one resting drug-insensitive population. The drug effect was included as an increase in the killing rate of the drug-susceptible bacteria with a maximum-effect (Emax) mode

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Nielsen, Elisabet I., Anders Viberg, Elisabeth Löwdin, Otto Cars, Mats O. Karlsson, and Marie Sandström. "Semimechanistic Pharmacokinetic/Pharmacodynamic Model for Assessment of Activity of Antibacterial Agents from Time-Kill Curve Experiments." Antimicrobial Agents and Chemotherapy 51, no. 1 (2006): 128–36. http://dx.doi.org/10.1128/aac.00604-06.

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ABSTRACT Dosing of antibacterial agents is generally based on point estimates of the effect, even though bacteria exposed to antibiotics show complex kinetic behaviors. The use of the whole time course of the observed effects would be more advantageous. The aim of the present study was to develop a semimechanistic pharmacokinetic (PK)/pharmacodynamic (PD) model characterizing the events seen in a bacterial system when it is exposed to antibacterial agents with different mechanisms of action. Time-kill curve experiments were performed with a strain of Streptococcus pyogenes exposed to a wide ra

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Sheppard, Sean, and Duygu Dikicioglu. "Dynamic modelling of the killing mechanism of action by virus-infected yeasts." Journal of The Royal Society Interface 16, no. 152 (2019): 20190064. http://dx.doi.org/10.1098/rsif.2019.0064.

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Killer yeasts are microorganisms, which can produce and secrete proteinaceous toxins, a characteristic gained via infection by a virus. These toxins are able to kill sensitive cells of the same or a related species. From a biotechnological perspective, killer yeasts are beneficial due to their antifungal/antimicrobial activity, but also regarded as problematic for large-scale fermentation processes, whereby those yeasts would kill starter cultures species and lead to stuck fermentations. Here, we propose a mechanistic model of the toxin-binding kinetics pertaining to the killer population coup

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Pérez-Rodríguez, Martín, Marta López Cabo, Eva Balsa-Canto, and Míriam R. García. "Mechanisms of Listeria monocytogenes Disinfection with Benzalkonium Chloride: From Molecular Dynamics to Kinetics of Time-Kill Curves." International Journal of Molecular Sciences 24, no. 15 (2023): 12132. http://dx.doi.org/10.3390/ijms241512132.

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Unravelling the mechanisms of action of disinfectants is essential to optimise dosing regimes and minimise the emergence of antimicrobial resistance. In this work, we examined the mechanisms of action of a commonly used disinfectant—benzalkonium chloride (BAC)—over a significant pathogen—L. monocytogenes—in the food industry. For that purpose, we used modelling at multiple scales, from the cell membrane to cell population inactivation. Molecular modelling revealed that the integration of the BAC into the membrane requires three phases: (1) the approaching of BAC to the cellular membrane, (2) t

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Meyer, Christina, Kai Lucaβen, Stefanie Gerson, et al. "Contribution of RND-Type Efflux Pumps in Reduced Susceptibility to Biocides in Acinetobacter baumannii." Antibiotics 11, no. 11 (2022): 1635. http://dx.doi.org/10.3390/antibiotics11111635.

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Bacterial efflux pumps are among the key mechanisms of resistance against antibiotics and biocides. We investigated whether differential expression levels of the RND-type efflux pumps AdeABC and AdeIJK impacted the susceptibility to commonly used biocides in multidrug-resistant Acinetobacter baumannii. Susceptibility testing and time–kill assays of defined laboratory and clinical A. baumannii strains with different levels of efflux pump expression were performed after exposure to the biocides benzalkonium chloride, chlorhexidine digluconate, ethanol, glucoprotamin, octenidine dihydrochloride,

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Kumar, Manoj, Tarun Mathur, Tarani K. Barman, et al. "In VitroandIn VivoActivities of the Novel Ketolide RBx 14255 against Clostridium difficile." Antimicrobial Agents and Chemotherapy 56, no. 11 (2012): 5986–89. http://dx.doi.org/10.1128/aac.00015-12.

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ABSTRACTThe MIC90of RBx 14255, a novel ketolide, againstClostridium difficilewas 4 μg/ml (MIC range, 0.125 to 8 μg/ml), and this drug was found to be more potent than comparator drugs. Anin vitrotime-kill kinetics study of RBx 14255 showed time-dependent bacterial killing forC. difficile. Furthermore, in the hamster model ofC. difficileinfection, RBx 14255 demonstrated greater efficacy than metronidazole and vancomycin, making it a promising candidate forC. difficiletreatment.

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Credito, Kim L., Lois M. Ednie, Michael R. Jacobs, and Peter C. Appelbaum. "Activity of Telithromycin (HMR 3647) against Anaerobic Bacteria Compared to Those of Eight Other Agents by Time-Kill Methodology." Antimicrobial Agents and Chemotherapy 43, no. 8 (1999): 2027–31. http://dx.doi.org/10.1128/aac.43.8.2027.

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ABSTRACT Time-kill studies examined the activities of telithromycin (HMR 3647), erythromycin A, azithromycin, clarithromycin, roxithromycin, clindamycin, pristinamycin, amoxicillin-clavulanate, and metronidazole against 11 gram-positive and gram-negative anaerobic bacteria. Time-kill studies were carried out with the addition of Oxyrase in order to prevent the introduction of CO2. Macrolide-azalide-ketolide MICs were 0.004 to 32.0 μg/ml. Of the latter group, telithromycin had the lowest MICs, especially against non-Bacteroides fragilis group strains, followed by azithromycin, clarithromycin, e

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McKay, G. A., S. Beaulieu, F. F. Arhin, et al. "Time-kill kinetics of oritavancin and comparator agents against Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium." Journal of Antimicrobial Chemotherapy 63, no. 6 (2009): 1191–99. http://dx.doi.org/10.1093/jac/dkp126.

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Sy, Sherwin K. B., Luning Zhuang, Huiming Xia, et al. "A mathematical model-based analysis of the time–kill kinetics of ceftazidime/avibactam against Pseudomonas aeruginosa." Journal of Antimicrobial Chemotherapy 73, no. 5 (2018): 1295–304. http://dx.doi.org/10.1093/jac/dkx537.

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Nagl, Markus, Claudia Neher, Josef Hager, Bettina Pfausler, Erich Schmutzhard, and Franz Allerberger. "Bactericidal Activity of Vancomycin in Cerebrospinal Fluid." Antimicrobial Agents and Chemotherapy 43, no. 8 (1999): 1932–34. http://dx.doi.org/10.1128/aac.43.8.1932.

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ABSTRACT Intraventricular application of vancomycin is an effective therapeutic regimen for the treatment of shunt-associated staphylococcal ventriculitis. We examined the in vitro activity of vancomycin at high concentrations against Staphylococcus aureus ATCC 25923 and Staphylococcus epidermidis ATCC 12228 in human cerebrospinal fluid samples. Time-kill curves revealed equal efficacies for concentrations of 10, 100, and 300 μg/ml, and incubation times of 24 to 48 h were needed to achieve a 3 log10 reduction of viable bacteria. A concentration of 5 μg/ml showed a slightly lower activity, but

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Antoniadou, Maria, Georgios Rozos, Natalia Vaiou, et al. "The In Vitro Assessment of Antibacterial and Antioxidant Efficacy in Rosa damascena and Hypericum perforatum Extracts against Pathogenic Strains in the Interplay of Dental Caries, Oral Health, and Food Microbiota." Microorganisms 12, no. 1 (2023): 60. http://dx.doi.org/10.3390/microorganisms12010060.

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The rising demand for novel antibiotic agents prompts an investigation into natural resources, notably plant-derived compounds. In this study, various extracts (aqueous, ethanolic, aqueous-ethanolic, and enzymatic) of Rosa damascena and Hypericum perforatum were systematically evaluated against bacterial strains isolated from dental lesions (n = 6) and food sources (raw milk and broiler carcass, n = 2). Minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), antibiofilm activity, and time-kill kinetics were assessed across a range of extract concentrations, revealing

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Spangler, S. K., M. R. Jacobs, and P. C. Appelbaum. "MIC and time-kill studies of antipneumococcal activity of GV 118819X (sanfetrinem) compared with those of other agents." Antimicrobial Agents and Chemotherapy 41, no. 1 (1997): 148–55. http://dx.doi.org/10.1128/aac.41.1.148.

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Agar dilution MIC methodology was used to test the activities of GV 118819X (sanfetrinem), ampicillin, amoxicillin, amoxicillin-clavulanate, cefpodoxime, loracarbef, levofloxacin, clarithromycin, ceftriaxone, imipenem, and vancomycin against 53 penicillin-susceptible, 84 penicillin-intermediate and 74 penicillin-resistant pneumococci isolated in the United States. GV 118819X was the most active oral beta-lactam, with MIC at which 50% of the isolates were inhibited (MIC50)/MIC90 values of 0.008/0.03, 0.06/0.5, and 0.5/1.0 micrograms/ml against penicillin-susceptible, -intermediate, and -resista

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Chapnick, Edward K., Jeremy D. Gradon, Barry Kreiswirth, et al. "Comparative Killing Kinetics of Methicillin-Resistant Staphylococcus aureus by Bacitracin or Mupirocin." Infection Control & Hospital Epidemiology 17, no. 3 (1996): 178–80. http://dx.doi.org/10.1017/s0195941700006548.

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AbstractThe in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost.

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Uchejeso, Obeta M. "Time Kill Kinetics Study of Commonly Used Disinfectants against Pseudomonas aeruginosa in Federal Medical Centre, Umuahia-Nigeria." American Journal of Biomedical Science & Research 7, no. 3 (2020): 262–68. http://dx.doi.org/10.34297/ajbsr.2020.07.001155.

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Hoellman, Dianne B., Linda M. Kelly, Kim Credito, et al. "In Vitro Antianaerobic Activity of Ertapenem (MK-0826) Compared to Seven Other Compounds." Antimicrobial Agents and Chemotherapy 46, no. 1 (2002): 220–24. http://dx.doi.org/10.1128/aac.46.1.220-224.2002.

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ABSTRACT Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active β-lactams (MICs at which 50% of the strains are inhibited [MIC50s], 0.125 to 0.25 μg/ml; MIC90s, 1.0 to 2.0 μg/ml). Time-kill studies revealed that ertapenem at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other β-lactams were similar to those of ertapenem.

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Bax, Hannelore I., Corné P. de Vogel, Johan W. Mouton, and Jurriaan E. M. de Steenwinkel. "Omadacycline as a promising new agent for the treatment of infections with Mycobacterium abscessus." Journal of Antimicrobial Chemotherapy 74, no. 10 (2019): 2930–33. http://dx.doi.org/10.1093/jac/dkz267.

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Abstract Background Despite intensive treatment regimens, the outcome of Mycobacterium abscessus infections is extremely poor and thus novel treatment regimens are needed. Although tigecycline seems to be one of the best options currently available, its long-term use is hampered by severe toxic side effects as well as the need for intravenous administration and the relatively high concentrations required for efficacy. Objectives To assess the in vitro activity of omadacycline against M. abscessus and compare it with the activity of tigecycline. Methods The concentration- and time-dependent kil

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Gunderson, Shana M., Robert A. Hayes, John P. Quinn, and Larry H. Danziger. "In Vitro Pharmacodynamic Activities of ABT-492, a Novel Quinolone, Compared to Those of Levofloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis." Antimicrobial Agents and Chemotherapy 48, no. 1 (2004): 203–8. http://dx.doi.org/10.1128/aac.48.1.203-208.2004.

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ABSTRACT ABT-492 is a novel quinolone with potent activity against gram-positive, gram-negative, and atypical pathogens, making this compound an ideal candidate for the treatment of community-acquired pneumonia. We therefore compared the in vitro pharmacodynamic activity of ABT-492 to that of levofloxacin, an antibiotic commonly used for the treatment of pneumonia, through MIC determination and time-kill kinetic analysis. ABT-492 demonstrated potent activity against penicillin-sensitive, penicillin-resistant, and levofloxacin-resistant Streptococcus pneumoniae strains (MICs ranging from 0.0078

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Hawkins-Daarud, Andrea, Russell Rockne, David Corwin, Alexander R. A. Anderson, Paul Kinahan, and Kristin R. Swanson. "In silico analysis suggests differential response to bevacizumab and radiation combination therapy in newly diagnosed glioblastoma." Journal of The Royal Society Interface 12, no. 109 (2015): 20150388. http://dx.doi.org/10.1098/rsif.2015.0388.

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Recently, two phase III studies of bevacizumab, an anti-angiogenic, for newly diagnosed glioblastoma (GBM) patients were released. While they were unable to statistically significantly demonstrate that bevacizumab in combination with other therapies increases the overall survival of GBM patients, there remains a question of potential benefits for subpopulations of patients. We use a mathematical model of GBM growth to investigate differential benefits of combining surgical resection, radiation and bevacizumab across observed tumour growth kinetics. The differential hypoxic burden after gross t

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de Carvalho, Priscila Goes Camargo, Jhonatan Macedo Ribeiro, Renata Perugini Biasi Garbin, et al. "Synthesis and Antimicrobial Activity of Thiohydantoins Obtained from L-Amino Acids." Letters in Drug Design & Discovery 17, no. 1 (2019): 94–102. http://dx.doi.org/10.2174/1570180816666181212153011.

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Background: Thiohydantoins are an important class of heterocyclic compounds in drug discovery since they are related to a wide range of biological properties including antimicrobial activity. Objective: The objective of this study was to synthesize a series of thiohydantoins derived from Laminoacids and to evaluated their inhibitory effect on the growth of Gram-negative and Grampositive bacteria. Methods: All title compounds were synthetized by reaction of L-amino acids with thiourea or ammonium thiocyanate. Their antimicrobial activities were evaluated against bacterial strains by broth micro

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