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1
Petcher, P. A. "Time of flight diffraction and imaging (TOFDI)." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/49478/.
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Time of flight diffraction and imaging (TOFDI) is based on time of flight diffraction (TOFD), adding cross-sectional imaging of the sample bulk by exploiting the scattering of ultrasonic waves from bulk defects in metals. Multiple wave modes are emitted by a pulsed laser ultrasound ablative source, and received by a sparse array of receiving electromagnetic acoustic transducers (EMATs), for non-contact (linear) scanning, with mode-conversions whenever waves are scattered. Standard signal processing techniques, such as band-pass filters, reduce noise. A B-scan is formed from multiple data captures (A-scans), with time and scan position axes, and colour representing amplitude or magnitude. B-scans may contain horizontal lines from surface waves propagating directly from emitter to receiver, or via a back-wall, and angled lines after reflection off a surface edge. A Hough transform (HT), modified to deal with the constraints of a B-scan, can remove such lines. A parabola matched filter has been developed that identifies the features in the B-scan caused by scattering from point-like defects, reducing them to peaks and minimising noise. Multiple B-scans are combined to reduce noise further. The B-scan is also processed to form a cross-sectional image, enabling detection and positioning of multiple defects. The standard phase correlation technique applied to camera images, has been used to track the relative position between transducer and sample. Movement has been determined to sub-pixel precision, with a median accuracy of 0.01mm of linear movement (0.06 of a pixel), despite uneven illumination and the use of a basic low resolution camera. The prototype application is testing rough steel products formed by continuous casting, but the techniques created to facilitate operation of TOFDI are applicable elsewhere.
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Mei, Jonathan (Jonathan B. ). "Algorithms for 3D time-of-flight imaging." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/85609.
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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2013.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 57-58).
This thesis describes the design and implementation of two novel frameworks and processing schemes for 3D imaging based on time-of- flight (TOF) principles. The first is a low power, low hardware complexity technique based on parametric signal processing for orienting and localizing simple planar scenes. The second is an improved method for simultaneously performing phase unwrapping and denoising for sinusoidal amplitude modulated continuous wave ToF cameras using multiple frequencies. The first application uses several unfocused photodetectors with high time resolution to estimate information about features in the scene. Because the time profiles of the responses for each sensor are parametric in nature, the recovery algorithm uses finite rate of innovation (FRI) methods to estimate signal parameters. The signal parameters are then used to recover the scene features. The second application uses a generalized approximate message passing (GAMP) framework to incorporate both accurate probabilistic modeling for the measurement process and underlying scene depth map sparsity to accurately extend the unambiguous depth range of the camera. This joint processing results in improved performance over separate unwrapping and denoising steps.
by Jonathan Mei.
M. Eng.
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Lee, Jason W. L. "Novel developments in time-of-flight particle imaging." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:195be057-7ce0-4a15-b639-b08892fde312.
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In the field of physical chemistry, the relatively recently developed technique of velocity-map imaging has allowed chemical dynamics to be explored with a greater depth than could be previously achieved using other methods. Capturing the scattering image associated with the products resulting from fragmentation of a molecule allows the dissociative pathways and energy landscape to be investigated. In the study of particle physics, the neutron has become an irreplaceable spectroscopic tool due to the unique nature of the interaction with certain materials. Neutron spectroscopy is a non-destructive imaging technique that allows a number of properties to be discerned, including chemical identification, strain tensor measurements and the identification of beneath the sample surface using radiography and tomography. In both of these areas, as well as a multitude of other disciplines, a flight tube is used to separate particles, distinguishing them based upon their mass in the former case and their energy in the latter. The experiments can be vastly enhanced by the ability to record both the position and arrival time of the particle of interest. This thesis describes several new developments made in instrumentation for experiments involving time-of-flight particle imaging. The first development described is the construction of a new velocity-map imaging instrument that utilises electron ionisation to perform both steps of molecular fragmentation and ionisation. Data from CO2 is presented as an example of the ability of the instrument, and a preliminary analysis of the images is performed. The second presented project is the design of a time-resolved and position-resolved detector developed for ion imaging experiments. The hardware, software and firmware are described and presented alongside data from a variety of the experiments showcasing the breadth of investigations that are possible using the sensor. Finally, the modifications made to the detector to allow time-resolved neutron imaging are detailed, with an in-depth description of the various proof-of-concept experiments carried out as part of the development process.
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Calvert, N. "Time-of-flight Compton scatter imaging for cargo security." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1503664/.
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By measuring the time of flight of scattered x-ray photons, the point of interaction, assuming a single scatter, can be determined, providing a three dimensional image of cargo containers. The present work introduces the technique, and provides experimental and theoretical results to show the feasibility of such a technique. Monte Carlo simulations were performed to investigate the proportion of multiple scatter detected using a proposed experimental setup, and it was found that it accounted for almost 50% of the recorded signal. Monte Carlo simulations of a scintillation detector were provided and used to design the detectors used. Experimental measurements at a picosecond length x-ray source resulted in the reconstruction of scatter position of photons interacting in a 5 cm thick test object to an accuracy of 12 cm full width at half maximum. Preliminary experiments were also performed using a conventional commercially available linear accelerator with a pulse length of 170 ns. Deconvolution techniques were applied to the recorded data to estimate the position of scatter. An analytic single scatter forward model was derived from the radiative transfer equation, discretised and the inverse problem was solved using a number of different methods. The alternating direction method of multipliers was adapted for nonlinear problems and provided image quality that was comparable to the gold standard linear method.
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Yoon, Oh Kyu. "Continuous time-of-flight mass spectrometric imaging of fragmented ions /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
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Noraky, James. "Algorithms and systems for low power time-of-flight imaging." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/127029.
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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, May, 2020Cataloged from the official PDF of thesis.
Includes bibliographical references (pages 151-158).
Depth sensing is useful for many emerging applications that range from augmented reality to robotic navigation. Time-of-flight (ToF) cameras are appealing depth sensors because they obtain dense depth maps with minimal latency. However, for mobile and embedded devices, ToF cameras, which obtain depth by emitting light and estimating its roundtrip time, can be power-hungry and limit the battery life of the underlying device. To reduce the power for depth sensing, we present algorithms to address two scenarios. For applications where RGB images are concurrently collected, we present algorithms that reduce the usage of the ToF camera and estimate new depth maps without illuminating the scene. We exploit the fact that many applications operate in nearly rigid environments, and our algorithms use the sparse correspondences across the consecutive RGB images to estimate the rigid motion and use it to obtain new depth maps.
Our techniques can reduce the usage of the ToF camera by up to 85%, while still estimating new depth maps within 1% of the ground truth for rigid scenes and 1.74% for dynamic ones. When only the data from a ToF camera is used, we propose algorithms that reduce the overall amount of light that the ToF camera emits to obtain accurate depth maps. Our techniques use the rigid motions in the scene, which can be estimated using the infrared images that a ToF camera obtains, to temporally mitigate the impact of noise. We show that our approaches can reduce the amount of emitted light by up to 81% and the mean relative error of the depth maps by up to 64%. Our algorithms are all computationally efficient and can obtain dense depth maps at up to real-time on standard and embedded computing platforms.
Compared to applications that just use the ToF camera and incur the cost of higher sensor power and to those that estimate depth entirely using RGB images, which are inaccurate and have high latency, our algorithms enable energy-efficient, accurate, and low latency depth sensing for many emerging applications.
by James Noraky.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science
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Westberg, Michael. "Time of Flight Based Teat Detection." Thesis, Linköping University, Department of Electrical Engineering, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19292.
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Time of flight is an imaging technique with uses depth information to capture 3D information in a scene. Recent developments in the technology have made ToF cameras more widely available and practical to work with. The cameras now enable real time 3D imaging and positioning in a compact unit, making the technology suitable for variety of object recognition tasks
An object recognition system for locating teats is at the center of the DeLaval VMS, which is a fully automated system for milking cows. By implementing ToF technology as part of the visual detection procedure, it would be possible to locate and track all four teat’s positions in real time and potentially provide an improvement compared with the current system.
The developed algorithm for teat detection is able to locate teat shaped objects in scenes and extract information of their position, width and orientation. These parameters are determined with an accuracy of millimeters. The algorithm also shows promising results when tested on real cows. Although detecting many false positives the algorithm was able to correctly detected 171 out of 232 visible teats in a test set of real cow images. This result is a satisfying proof of concept and shows the potential of ToF technology in the field of automated milking.
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Bhandari, Ayush. "Inverse problems in time-of-flight imaging : theory, algorithms and applications." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/95867.
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Thesis: S.M., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2014.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 100-108).
Time-of-Fight (ToF) cameras utilize a combination of phase and amplitude information to return real-time, three dimensional information of a scene in form of depth images. Such cameras have a number of scientific and consumer oriented applications. In this work, we formalize a mathematical framework that leads to unifying perspective on tackling inverse problems that arise in the ToF imaging context. Starting from first principles, we discuss the implications of time and frequency domain sensing of a scene. From a linear systems perspective, this amounts to an operator sampling problem where the operator depends on the physical parameters of a scene or the bio-sample being investigated. Having presented some examples of inverse problems, we discuss detailed solutions that benefit from scene based priors such sparsity and rank constraints. Our theory is corroborated by experiments performed using ToF/Kinect cameras. Applications of this work include multi-bounce light decomposition, ultrafast imaging and fluorophore lifetime estimation.
by Ayush Bhandari.
S.M.
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Winter, Benjamin. "Novel methods in imaging mass spectrometry and ion time-of-flight detection." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:43db5039-0490-4f97-8519-4d3ed4e30ca3.
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Imaging mass spectrometry (IMS) in microscope mode allows the spatially resolved molecular constitution of a large sample section to be analysed in a single experiment. If performed in a linear mass spectrometer, the applicability of microscope IMS is limited by a number of factors: the low mass resolving power of the employed ion optics; the time resolution afforded by the scintillator screen based particle detector and the multi-hit capability, per pixel, of the employed imaging sensor. To overcome these limitations, this thesis concerns the construction of an advanced ion optic employing a pulsed extraction method to gain a higher ToF resolution, the development of a bright scintillator screen with short emission lifetime, and the application of the Pixel Imaging Mass Spectrometry (PImMS) sensor with multi-mass imaging and time stamping capabilities. Initial experimental results employing a three electrode ion optic to spatially map ions emitted from a sample surface are presented. By applying a static electric potential a time-of-flight resolution of t/2Δt=54 and a spatial resolution of 20 μm are determined across a field-of-view of 4 mm diameter. While the moderate time-of-flight resolution only allows particles separated by a few Dalton to be distinguished, the instrument is used to demonstrate the multi-mass imaging capabilities of the PImMS sensor when being applied to image grid structures or tissue samples. An improved time-of-flight resolution is achieved by post extraction differential acceleration of a selected range of ions (up to 100 Da) using a newly developed five electrode ion optic. This modification is shown to correct the initial velocity spread of the ions coming off the sample surface, which yields an enhanced time-of-flight resolution of t/2Δt=2000 . The spatial resolution of the instrument is found to be 20 μm across a field-of-view of 4 mm. Adjusting the extraction field strength applied to the ion optic of the constructed mass spectrometer allows the optimised mass range to be tuned to any mass of interest. Ion images are recorded for various samples with comparable spatial and ToF resolution. Hence, studies on tissue sections and multi sample arrays become accessible with the improved design and operational principle of the microscope mode IMS instrument. A fast and efficient conversion of impinging ions into detectable flashes of light, which can consequently be recorded by a fast imaging sensor, is essential to maintain the achievable time-of-flight and spatial resolution of the IMS instrument constructed. In order to find a suitable fast and bright scintillator to be applied in a microchannel based particle detector, various inorganic and organic substances are characterised in terms of their emission properties following electron excitation. Poly-para-phenylene laser dye screens are found to show an outstanding performance among all substances analysed. An emission life time of below 4 ns and a brightness exceeding that of a P47 screen (industry standard) by a factor 2× is determined. No signal degradation is observed over an extended period, and the spatial resolution is found to be comparable to commercial imaging detectors. Hence, these scintillator screens are fully compatible with any ion imaging application requiring a high time resolution. In a further series of mass spectrometric experiments, ions are accelerated onto a scintillator mounted in front of a multi pixel photon counter. The charged particle impact stimulated the emission of a few photons, which are collected by the fast photon counter. Poly-para-phenylene laser dyes again show an outstanding efficiency for the conversion of ions into photons, resulting in a signal enhancement of up to 5× in comparison to previous experiments, which employed an inorganic LYSO scintillator.
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Mutamba, Q. B. "Time of flight imaging with 3MeV neutrons based on the associated particle technique." Thesis, Swansea University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.638284.
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Spatial imaging using the time of flight (TOF) method with 3 MeV neutrons based on the associated particle technique has been demonstrated to produce a tomographic image of an aluminium test object. The imaging set-up used coincidence detection of the neutron-induced inelastic scattered gamma rays from the 27Al(n,n'γ)27 Al nuclear reaction in the test object, and the associated 3He particles from the TiD self-implanted target. The test object was positioned 120 cm away from the target, and rotated in the neutron beam at 72 evenly spaced angles of orientation. The TOF spectrum data that were obtained at each angle were used in the image reconstruction computer programme that used the technique of filtered back-projection to produce the image of the test object. In order to remove deficiencies in the image reconstruction programme, it was tested first with computer simulated TOF spectrum data for the neutrons and the gamma rays that were gathered, using assumptions that were based on experimental conditions. At optimum timing resolution of 1.4 ns and a timing efficiency of 2.2% for the 3He-gamma coincidence were achieved. An equivalent dose of 69.1 μSv per scan was delivered to the test object, and it received a total dose of 4.98 mSv during the 72 scans. A good image of the test object was obtained that had clearly distinguishable walls above the background due to chance coincidence signals. With the possible improvements in the detection efficiency for gamma rays, the timing resolution, and the timing efficiency, we envisage a medical application of the imaging technique to provide spatial information of overloaded elements in parts of the human body as a result of certain diseases. We consider the imaging of aluminium in the bone for patients with chronic renal failure and that of iron in the liver for patients with a haemochromatosis.
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Berrueta, Razo Irma. "Molecular imaging of mouse brain tissue using Cluster Time-of-Flight Secondary Ion Mass Spectrometry." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/molecular-imaging-of-mouse-brain-tissue-using-cluster-timeofflight-secondary-ion-mass-spectrometry(a350dc50-5337-4d32-a95c-24c617bbba97).html.
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ToF-SIMS imaging has been drawing attention due to the wide range of applications in the biological and biomedical fields. These applications include the acquisition of quantitative and qualitative data that ranges in scale from single cells to organs, image visualisation and interpretation of biomarkers for diagnosis and development of pharmaceutics. This study focused on molecular imaging of mouse brain tissue sections using cluster primary ion beams. First, cluster ion beams were applied to comparative background studies of biomolecules and brain total lipid extract. Enhancement of the secondary ion signal was observed using water-containing cluster primary ion beams, especially for [M+H]+ type secondary ions. Water-containing clusters were then used to acquire ToF-SIMS images from the cerebellar area of serial mouse brain tissue sections. Again, water-containing cluster beams produced the highest secondary ion yields in both grey and white matter, gaining a new level of insight into the lipid compositions of both types of tissue in the brain. A clinical case was also evaluated with ToF-SIMS imaging, using cluster beams for the analysis of 3xTg-AD mouse brain tissue. SIMS images were registered with fluorescence microscopy images for the in situ identification and co-localisation of the Amyloid-β plaques on the SIMS images. Spectra from regions of interest were analysed to identify possible ion fragments derived from the Aβ protein. The co-localisation of cholesterol was also studied from images obtained with different primary ion beams. The results presented show that cluster ToF-SIMS can be successfully applied to brain tissue imaging. New primary ion beam technologies allow us to acquire data with more useful secondary ion yield for clinical applications and biological research. Nevertheless, future technological improvements are required for specialised applications e.g. cellular imaging. Moreover, processing the data obtained is still challenging and more data processing tools are also needed for interpretation.
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Dutton, Neale Arthur William. "CMOS SPAD-based image sensor for single photon counting and time of flight imaging." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/15968.
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The facility to capture the arrival of a single photon, is the fundamental limit to the detection of quantised electromagnetic radiation. An image sensor capable of capturing a picture with this ultimate optical and temporal precision is the pinnacle of photo-sensing. The creation of high spatial resolution, single photon sensitive, and time-resolved image sensors in complementary metal oxide semiconductor (CMOS) technology offers numerous benefits in a wide field of applications. These CMOS devices will be suitable to replace high sensitivity charge-coupled device (CCD) technology (electron-multiplied or electron bombarded) with significantly lower cost and comparable performance in low light or high speed scenarios. For example, with temporal resolution in the order of nano and picoseconds, detailed three-dimensional (3D) pictures can be formed by measuring the time of flight (TOF) of a light pulse. High frame rate imaging of single photons can yield new capabilities in super-resolution microscopy. Also, the imaging of quantum effects such as the entanglement of photons may be realised. The goal of this research project is the development of such an image sensor by exploiting single photon avalanche diodes (SPAD) in advanced imaging-specific 130nm front side illuminated (FSI) CMOS technology. SPADs have three key combined advantages over other imaging technologies: single photon sensitivity, picosecond temporal resolution and the facility to be integrated in standard CMOS technology. Analogue techniques are employed to create an efficient and compact imager that is scalable to mega-pixel arrays. A SPAD-based image sensor is described with 320 by 240 pixels at a pitch of 8μm and an optical efficiency or fill-factor of 26.8%. Each pixel comprises a SPAD with a hybrid analogue counting and memory circuit that makes novel use of a low-power charge transfer amplifier. Global shutter single photon counting images are captured. These exhibit photon shot noise limited statistics with unprecedented low input-referred noise at an equivalent of 0.06 electrons. The CMOS image sensor (CIS) trends of shrinking pixels, increasing array sizes, decreasing read noise, fast readout and oversampled image formation are projected towards the formation of binary single photon imagers or quanta image sensors (QIS). In a binary digital image capture mode, the image sensor offers a look-ahead to the properties and performance of future QISs with 20,000 binary frames per second readout with a bit error rate of 1.7 x 10-3. The bit density, or cumulative binary intensity, against exposure performance of this image sensor is in the shape of the famous Hurter and Driffield densitometry curves of photographic film. Oversampled time-gated binary image capture is demonstrated, capturing 3D TOF images with 3.8cm precision in a 60cm range.
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Van, Nuffel Sebastiaan. "Three-dimensional time-of-flight secondary ion mass spectrometry imaging of primary neuronal cell cultures." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/39644/.
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Time-of-flight secondary ion mass spectrometry (ToF-SIMS) has proven its ability to characterise (in)organic surfaces, and is increasingly used for the characterisation of biological samples such as single cells. By combining ion imaging and molecular depth profiling it is possible to render 3D chemical images, which provides a novel, label-free way to investigate biological systems. Major challenges lie, however, in the development of data analysis tools and protocols that preserve the cell morphology. Here, we develop and employ such tools and protocols for the investigation of neuronal networks. One of the reasons 3D ToF-SIMS imaging of cells is underused is the lack of powerful data analysis tools as 3D ToF-SIMS measurements generate very large data sets. To address this issue, we developed a method that allows the application of principal component analysis (PCA) to be expanded to large 3D images making 3D ToF-SIMS image processing of whole, intact cells and cellular networks with multivariate analysis now accessible on a routine basis. Using this method, we are able to separate cellular material from the substrate and can then correct z-offsets due to the cells' topography resulting in a more accurate surface heightmap. The method also facilitates differentiation between cellular components such as lipids and amino acids allowing the cell membrane, the cytoplasm and the extracellular matrix (ECM) to be easily distinguished from one another. These developments permit us to investigate the intracellular localisation of specific native and non-native compounds label-free, not just in single cells but also in larger cellular networks. The visualisation of the cellular uptake of non-native compounds, namely fluorescent dyes, in primary rat cortical neurons and the chemical differentiation between cell types, namely primary rat cortical neurons and retinal pigment epithelium (RPE) cells, are presented as applications. Even though the dyes have distinct fragment ions in the high mass range, it was not possible to detect the fluorophores by 3D ToF-SIMS imaging of freeze-dried cells. However, it was possible to detect distinct differences in the kind of ions detected for freeze-dried primary rat cortical neurons and RPE cells albeit in the low mass range. To obtain meaningful results, however, it is paramount that sample preparation does not induce significant physical or chemical changes. We present the first comprehensive comparison between large 3D ToF-SIMS images of freeze-dried and frozen-hydrated cells using PCA to facilitate the data analysis of these large data sets. A higher degree of colocalisation of the K+ signal with cell regions is observed for frozen-hydrated cells, which indicates a lower degree of membrane damage and migration of diffusible chemical species. Frozen-hydrated cell samples are therefore considered to best reflect the native cell state, but freeze-dried cell samples allow far easier sample handling. The mass spectrum of frozen-hydrated cellular material also has increased ion intensities for higher-mass fragments, which is an additional advantage, because the poor signal-to-noise ratio of molecular species with m/z > 200 is a major bottleneck in the advancement of ToF-SIMS imaging as a diagnostic tool.
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Nguyen, Krzysztof Quoc Khanh. "Characterisation of holographic projection as structured illumination in a Time-of-Flight based 3D imaging system." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9953.
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This thesis describes work on a novel 3D imaging system that successfully implements optical feedback and noise rejection mechanisms. The system is a combination of three relatively new technologies, namely, holographic projection, Time of Flight (ToF) ranging and Single Photon Avalanche Diode (SPAD) sensors. Holographic projection is used to provide structured illumination with optical feedback instead of more commonly used uniform illumination in similar imaging systems. It is obtained using a Ferro-electric Liquid Crystal on Silicon Spatial Light Modulator (FLCoS SLM). The structured illumination with optical feedback can be operated at up to 60 Hz with the current device, and has been shown to provide an average gain of about 1.56 in useful light levels. Alternatively, a gain over a limited area of up to a factor of 9 is possible with the current system. Time of Flight ranging is a method of choice for the system when depth estimation is concerned. It works even at very low light levels and allows for sub-centimetre depth resolution. ToF method was implemented using 20 MHz laser diode with 50 ps pulse duration and 200 mW peak power, as well as a SPAD sensor. The SPAD sensor consisted of a 32 32 array of 50 μm pixels, each with 10 bit Time to Digital Converter (TDC) with 50 ps timing resolution. Sensor pixels feature 100 Hz mean Dark Count Rate (DCR). The use of SPAD sensors with an adaptive sensing algorithm presented in this work has been demonstrated to reduce effective noise levels as seen by the sensor by a factor of 16. As a result, a significant gain in depth resolution can be achieved. The quantification of this gain is explained in more detail within this work. Furthermore, the work describes in detail system design, methodology of experimental procedure as well as different algorithms essential to the correct operation of the system. Significant amount of time is dedicated to diffraction pattern generation for the use in holographic projection, as well as modelling of photon detection in SPAD sensors and associated peak detection necessary to extract depth information from histograms of timed of photons. Moreover, the thesis discusses potential applications for the system based on the results of system characterisation presented in this work. The current state of the system suggests best suitability for gaming and machine vision applications. Finally, the work offers potential solutions to the practical issues that remain unresolved in the current system, alternatives for components used and paths for potential future development of the system proposed.
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Nair, Rahul [Verfasser], and Bernd [Akademischer Betreuer] Jähne. "Analysis and Modeling of Passive Stereo and Time-of-Flight Imaging / Rahul Nair ; Betreuer: Bernd Jähne." Heidelberg : Universitätsbibliothek Heidelberg, 2015. http://d-nb.info/1180395069/34.
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Neimert-Andersson, Thomas. "3D imaging using time-correlated single photon counting." Thesis, Uppsala University, Signals and Systems Group, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-121104.
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This project investigates a laser radar system. The system is based on the principles of time-correlated single photon counting, and by measuring the times-of-flight of reflected photons it can find range profiles and perform three-dimensional imaging of scenes. Because of the photon counting technique the resolution and precision that the system can achieve is very high compared to analog systems. These properties make the system interesting for many military applications. For example, the system can be used to interrogate non-cooperative targets at a safe distance in order to gather intelligence. However, signal processing is needed in order to extract the information from the data acquired by the system. This project focuses on the analysis of different signal processing methods.
The Wiener filter and the Richardson-Lucy algorithm are used to deconvolve the data acquired by the photon counting system. In order to find the positions of potential targets different approaches of non-linear least squares methods are tested, as well as a more unconventional method called ESPRIT. The methods are evaluated based on their ability to resolve two targets separated by some known distance and the accuracy with which they calculate the position of a single target, as well as their robustness to noise and their computational burden.
Results show that fitting a curve made of a linear combination of asymmetric super-Gaussians to the data by a method of non-linear least squares manages to accurately resolve targets separated by 1.75 cm, which is the best result of all the methods tested. The accuracy for finding the position of a single target is similar between the methods but ESPRIT has a much faster computation time.
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Schmidt, Mirko [Verfasser], and Bernd [Akademischer Betreuer] Jähne. "Analysis, Modeling and Dynamic Optimization of 3D Time-of-Flight Imaging Systems / Mirko Schmidt ; Betreuer: Bernd Jähne." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/1179229568/34.
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Habteyes, Terefe Getaneh. "Electronic Structure and Photochemistry of Molecular and Cluster Anions via Tandem Time-of-Flight Mass Spectroscopy and Photoelectron Imaging." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195955.
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Molecular and cluster anions have been investigated using a newly built tandem time-of-flight mass spectrometer combined with photoelectron imaging system. Solvation particularly hydration is shown not only to stabilize metastable anions such as CO₂⁻ in their ground state and impede autodetachment but also to alter the dynamics in the excited states. For instance, the 355 nm photoelectron image of mass-selected CO₂⁻(H₂O)(m) evolves from anisotropic to isotropic as m increases indicating excited state decay via electron autodetachment. Dissociation channels open at m=2 at 266 nm, resulting in O−(H₂O)m-k and CO₂⁻(H₂O)(m-k) products, the later becoming dominant as m increases. The photoelectron imaging of (CS₂)₂⁻ has revealed the coexistence of four electronic isomers: CS₂⁻•CS₂ [C(s)(₂A′)] and three covalent C₂S₄⁻ [C₂ᵥ(²B₁), D(2h)(²B(3g)), and D(2d)( ²A₁)] structures. Water-mediated intermolecular interactions have been shown to facilitate the formation of the global minimum C₂ᵥ(²B₁) structure rather than the less stable local minima C(s)(₂A′) and D(2d)(²A₁) structures that are favored in the dry source condition. In the (CS2)(n)⁻, n ≥ 3 and (CS₂)₂⁻ (H₂O)(m), m > 0 clusters, the population of the C₂ᵥ(²B₁) structure diminishes drastically due to more favorable solvent interactions with the CS2 − monomercore. Photoexcitation of the (CS₂)₂⁻ also results in the formation of CS₂⁻ and C₂S₂⁻ at 532 nm, and C₂S₂⁻, CS₂⁻, CS₃⁻, S₂⁻, and S⁻ at 355 and 266 nm. The relative yields of C₂S₂⁻ is significantly higher when (CS₂)₂⁻ is formed under wet source condition suggesting C₂ᵥ(²B₁) structure as the origin of C₂S₂⁻. An abrupt decrease in the relative yield of C₂S₂⁻ is observed upon adding CS₂ or H₂O to (CS₂)₂⁻. The CS₂⁻ based clusters are the likely origin of the S− photoproduct, while CS₃⁻ is formed through the secondary S⁻+CS₂ reaction. Novel anions (CS₂O₂⁻ and CS₃O⁻) are observed in the CS₂+O₂+e⁻ reaction. The photoelectron imaging and photodissociation results of these and other anionic products are presented. In addition, CS₂⁻•O₂ ion-neutral complex is formed depending on the conditions in the ion source. Despite the positive electron affinity of O₂, no clear signature of O₂⁻•CS₂ ion-neutral complex is seen in the photoelectron image. CO₃⁻ ion is also formed abundantly as a result of CS₂+CO₂+O₂+e⁻ reaction.
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Hallman, L. (Lauri). "Single photon detection based devices and techniques for pulsed time-of-flight applications." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526210445.
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Abstract In this thesis, a new type of laser diode transmitter using enhanced gain-switching suitable for use with a single photon avalanche diode (SPAD) detector was developed and tested in the pulsed time-of-flight laser range finding (lidar) application. Several laser diode versions were tested and the driving electronics were developed. The driving electronics improvements enabled a pulsing frequency of up to 1 MHz, while the maximum laser output power was about 5–40 W depending on the laser diode dimensions. The large output power is advantageous especially in conditions of strong photon noise emerging from ambient light outdoors. The length of the laser pulse matches the jitter of a typical SPAD detector providing several advantages. The new laser pulser structure enables a compact rangefinder for 50 m distance measurement outdoors in sunny conditions with sub-centimeter precision (σ-value) at a valid distance measurement rate of more than 10 kHz, for example. Single photon range finding techniques were also shown to enable a char bed level measurement of a recovery boiler containing highly attenuating and dispersing flue gas. In addition, gated single photon detector techniques were shown to provide a rejection of fluorescent photons in a Raman spectroscope leading to a greatly improved signal-to-noise ratio. Photonic effects were also studied in the case of a pulsed time-of-flight laser rangefinder utilizing a linear photodetector. It was shown that signal photon noise has an effect on the optimum detector configuration, and that pulse detection jitter can be minimized with an appropriate timing discriminatorTiivistelmä Tässä työssä kehitettiin uudentyyppinen, tehostettua "gain-switchingiä" hyödyntävä laserdiodilähetin käytettäväksi yksittäisten fotonien avalanche-ilmaisimien (SPAD) kanssa, ja sitä testattiin pulssin lentoaikaan perustuvassa laseretäisyysmittaussovelluksessa. Useita laserdiodiversioita testattiin ja ohjauselektroniikkaa kehitettiin. Ohjauselektroniikan parannukset mahdollistivat jopa 1 MHz pulssitustaajuuden, kun taas laserin maksimiteho oli noin 5–40 W riippuen laserdiodin dimensioista. Suuri lähtöteho on edullinen varsinkin vahvoissa taustafotoniolosuhteissa ulkona. Laserpulssin pituus vastaa tyypillisen SPAD-ilmaisimen jitteriä tarjoten useita etuja. Uusi laserpulssitinrakenne mahdollistaa esimerkiksi kompaktin etäisyysmittarin 50 m mittausetäisyydelle ulkona aurinkoisessa olosuhteessa mm–cm -mittaustarkkuudella (σ-arvo) yli 10 kHz mittaustahdilla. Yksittäisten fotonien lentoaikamittaustekniikan osoitettiin myös mahdollistavan soodakattilan keon korkeuden mittauksen, jossa on voimakkaasti vaimentavaa ja dispersoivaa savukaasua. Lisäksi portitetun yksittäisten fotonien ilmaisutekniikan osoitettiin hylkäävän fluoresenssin synnyttämiä fotoneita Raman-spektroskoopissa, joka johtaa selvästi parempaan signaali-kohinasuhteeseen. Fotoni-ilmiöitä tutkittiin myös lineaarista valoilmaisinta hyödyntävän pulssin kulkuaikamittaukseen perustuvan lasertutkan tapauksessa. Osoitettiin, että signaalin fotonikohina vaikuttaa optimaaliseen ilmaisinkonfiguraatioon, ja että pulssin ilmaisujitteri voidaan minimoida sopivalla ajoitusdiskriminaattorilla
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Hongming, Guo. "IMPROVING MATRIX DEPOSITION FOR SURFACE LAYER MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY IMAGING (SL-MALDI-TOF MSI)." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron155654549756264.
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Tian, Hua. "Visualisation and profiling of lipids in single biological cells using time-of-flight secondary ion mass spectrometry." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/visualisation-and-profiling-of-lipids-in-single-biological-cells-using-timeofflight-secondary-ion-mass-spectrometry(c36313be-4ffd-4809-b5c9-8fbe1f720bd1).html.
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Imaging Time-of-Flight secondary ion mass spectrometry (ToF-SIMS) has been developed to perform 2D imaging and depth profiling of biological systems with micron or submicron scale lateral resolution, which can be attributed to the advent of polyatomic ion beam particularly C60+ and new concept of ToF-SIMS instrument, the J105 3D Chemical Imager (J105). These recent advances in ToF-SIMS have opened a new dimension for biological analysis. In this study, 2D and 3D imaging have been performed on two biological systems, Xenopus laevis (X. laevis) zygote/embryo and murine embryonic fibroblasts NIH 3T3 BXB-ER cells to explore the capability of ToF-SIMS to handle the biological samples with extreme topography and high resolution depth profiling of microdomains, which still represent major challenges for the ToF-SIMS. The study on X. laevis embryo explored the capability of ToF-SIMS to handle spherical samples (approx. 1-1.2 mm in diameter), identify lipid species in mixtures of lipid extraction from the zygotes and image of an intact embryo in 2D/3D during dynamic biological events, e.g., fertilisation and early embryo development. For the first time the J105 and conventional BioToF-SIMS instrument were employed for the study of developmental biology. The major classes of lipid were identified through multiple lipid assay in a single analytical run using ToF-SIMS. Topography effects of the embryo were assessed through imaging a single intact zygote/embryo that revealed secondary ions loss at the edge of the single cell. However, the topography effects on the mass resolution could be minimised using the J105. Moreover, in situ lipid profiling of the zygote revealed different lipid compositions and intensities on the membrane of the animal and vegetal hemispheres. Furthermore, high resolution imaging and depth profiling that performed on a single intact cell in a time course study visualised the egg-sperm fusion sites on the membrane of the zygote 10 min post-insemination and lipids arrangement on the membrane of the embryo through the early development stages. Subcellular signalling upon the fertilisation was also spatially located on the serial cryosections of a single zygote. With the NIH 3T3 BXB-ER cells, the study firstly adopted a finely focused C60+ beam to track morphological changes and rearrangement of subcellular organelle mitochondria (0.5-2 µm) in response to the activation of Raf/ERK (extracellular signal regulated kinase) pathway using the J105. The SIMS images of the unlabelled cells showed the shifting of membrane distribution and nuclei shrinking following Raf/ERK activation. The mitochondria fluorescence probe within the cells were located 3-dimensionally using confocal microscopy and ToF-SIMS, which revealed the distribution pattern of condensing in the two sides of the nuclei following the Raf/ERK activation. Coupled with scanning electron microscopy (SEM), the three imaging modes showed good agreement in cellular morphological changes and subcellular mitochondrial rearrangement without or following Raf/ERK activation, demonstrating an integrated approaching to study the biological processes at subcellular dimension.
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Lu, Kuan. "Optimization Of Sublimation Conditions for Surface Layer Matrix-assisted Laser Desorption Ionization Time of Flight Mass Spectrometry Imaging (SL-MALDI- Tof MSI) of Polymer Surfaces." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1524846943404769.
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Yamamoto, Takayuki. "Magnetic resonance angiography with compressed sensing: an evaluation of moyamoya disease." Kyoto University, 2018. http://hdl.handle.net/2433/232119.
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Lamprou, Efthymios. "Development and Performance Evaluation of High Resolution TOF-PET Detectors Suitable for Novel PET Scanners." Doctoral thesis, Universitat Politècnica de València, 2021. http://hdl.handle.net/10251/162991.
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[ES] La Tomografía por Emisión de Positrones (PET) es una de las técnicas más importantes en la medicina de diagnóstico actual y la más representativa en el campo de la Imagen Molecular. Esta modalidad de imagen es capaz de producir información funcional única, que permite la visualización en detalle, cuantificación y conocimiento de una variedad de enfermedades y patologías. Áreas como la oncología, neurología o la cardiología, entre otras, se han beneficiado en gran medida de esta técnica. A pesar de que un elevado número de avances han ocurrido durante el desarrollo del PET, existen otros que son de gran interés para futuras investigaciones. Uno de los principales pilares actualmente en PET, tanto en investigación como en desarrollo, es la obtención de la información del tiempo de vuelo (TOF) de los rayos gamma detectados. Cuando esto ocurre, aumenta la sensibilidad efectiva del PET, mejorando la calidad señal-ruido de las imágenes. Sin embargo, la obtención precisa de la marca temporal de los rayos gamma es un reto que requiere, además de técnicas y métodos específicos, compromisos entre coste y rendimiento. Una de las características que siempre se ve afectada es la resolución espacial. Como discutiremos, la resolución espacial está directamente relacionada con el tipo de centellador y, por lo tanto, con el coste del sistema y su complejidad.
En esta tesis, motivada por los conocidos beneficios en imagen clínica de una medida precisa del tiempo y de la posición de los rayos gamma, proponemos configuraciones de detectores TOF- PET novedosos capaces de proveer de ambas características. Sugerimos el uso de lo que se conoce como métodos de "light-sharing", tanto basado en cristales monolíticos como pixelados de tamaño diferente al del fotosensor. Estas propuestas hacen que la resolución espacial sea muy alta. Sin embargo, sus capacidades temporales han sido muy poco abordadas hasta ahora. En esta tesis, a través de varios artículos revisados, pretendemos mostrar los retos encontrados en esta dirección, proponer determinadas configuraciones y, además, indagar en los límites temporales de éstas.
Hemos puesto un gran énfasis en estudiar y analizar las distribuciones de la luz centellante, así como su impacto en la determinación temporal. Hasta nuestro conocimiento, este es el primer trabajo en el que se estudia la relación de la determinación temporal y la distribución de luz de centelleo, en particular usando SiPM analógicos y ASICs. Esperamos que esta tesis motive y permita otros muchos trabajos orientados en nuevos diseños, útiles para instrumentación PET, así como referencia para otros trabajos.
Esta tesis esta organizada como se describe a continuación. Hay una introducción compuesta por tres capítulos donde se resumen los conocimientos sobre imagen PET, y especialmente aquellos relacionados con la técnica TOF-PET. Algunos trabajos recientes, pero aún no publicados se muestran también, con el objetivo de corroborar ciertas ideas. En la segunda parte se incluyen las cuatro contribuciones que el candidato sugiere para el compendio de artículos.[CA] La Tomografia per Emissió de Positrons (PET) és una de les tècniques més importants en la medicina de diagnòstic actual i la més representativa en el camp de la Imatge Molecular. Esta modalitat d'imatge és capaç de produir informació funcional única, que permet la visualització en detall, quantificació i coneixement d'una varietat de malalties i patologies. Àrees com l'oncologia, neurologia o la cardiologia, entre altres, s'han beneficiat en gran manera d'aquesta tècnica. Tot i que un elevat nombre d'avanços han ocorregut durant el desenvolupament del PET, hi ha altres que són de gran interés per a futures investigacions. Un dels principals pilars actuals en PET, tant en investigació com en desenvolupament, és l'obtenció de la informació del temps de vol (TOF en anglès) dels raigs gamma detectats. Quan açò ocorre, augmenta la sensibilitat efectiva del PET, millorant la qualitat senyal-soroll de les imatges. No obstant això, l'obtenció precisa de la marca temporal dels raigs gamma és un repte que requerix, a més de tècniques i mètodes específics, compromisos entre cost i rendiment. Una de les característiques que sempre es veu afectada és la resolució espacial. Com discutirem, la resolució espacial està directament relacionada amb el tipus de centellador, i per tant, amb el cost del sistema i la seua complexitat. En aquesta tesi, motivada pels coneguts beneficis en imatge clínica d'una mesura precisa del temps i de la posició dels raigs gamma, proposem nouves configuracions de detectors TOF-PET capaços de proveir d'ambduess característiques. Suggerim l'ús del que es coneix com a mètodes de "light-sharing", tant basat en cristalls monolítics com pixelats de diferent tamany del fotosensor. Aquestes propostes fan que la resolució espacial siga molt alta. No obstant això, les seues capacitats temporals han sigut molt poc abordades fins ara. En aquesta tesi, a través de diversos articles revisats, pretenem mostrar els reptes trobats en aquesta direcció, proposar determinades configuracions i, a més, indagar en els límits temporals d'aquestes. Hem posat un gran èmfasi a estudiar i analitzar les distribucions de la llum centellejant, així com el seu impacte en la determinació temporal. Fins al nostre coneixement, aquest és el primer treball en què s'estudia la relació de la determinació temporal i la distribució de llum de centelleig, en particular utilitzant SiPM analògics i ASICs. Esperem que aquesta tesi motive i permeta molts altres treballs orientats en nous dissenys, útils per a instrumentació PET, així com referència per a altres treballs. Aquesta tesi esta organitzada com es descriu a continuació. Hi ha una introducció composta per tres capítols on es resumeixen els coneixements sobre imatge PET i, especialmente, aquells relacionats amb la tècnica TOF-PET. Alguns treballs recents, però encara no publicats es mostren també, amb l'objectiu de corroborar certes idees. La segona part de la tesi conté els quatre articles revisats que el candidat suggereix.
[EN] Positron Emission Tomography (PET) is one of the greatest tools of modern diagnostic medicine and the most representative in the field of molecular imaging. This imaging modality, is capable of providing a unique type of functional information which permits a deep visualization, quantification and understanding of a variety of diseases and pathologies. Areas like oncology, neurology, or cardiology, among others, have been well benefited by this technique. Although numerous important advances have already been achieved in PET, some other individual aspects still seem to have a great potential for further investigation. One of the main trends in modern PET research and development, is based in the extrapolation of the Time- Of-Flight (TOF) information from the gamma-ray detectors. In such case, an increase in the effective sensitivity of PET is accomplished, resulting in an improved image signal-to-noise ratio. However, the direction towards a precise decoding of the photons time arrival is a challenging task that requires, besides specific approaches and techniques, tradeoffs between cost and performance. A performance characteristic very habitually compromised in TOF-PET detector configurations is the spatial resolution. As it will be discussed, this feature is directly related to the scintillation materials and types, and consequently, with system cost and complexity. In this thesis, motivated by the well-known benefits in clinical imaging of a precise time and spatial resolution, we propose novel TOF-PET detector configurations capable of inferring both characteristics. Our suggestions are based in light sharing approaches, either using monolithic detectors or crystal arrays with different pixel-to-photosensor sizes. These approaches, make it possible to reach a precise impact position determination. However, their TOF capabilities have not yet been explored in depth. In the present thesis, through a series of peer-reviewed publications we attempt to demonstrate the challenges encountered in these kinds of configurations, propose specific approaches improving their performance and eventually reveal their limits in terms of timing. High emphasis is given in analyzing and studying the scintillation light distributions and their impact to the timing determination. To the best of our knowledge, this is one of the first works in which such detailed study of the relation between light distribution and timing capabilities is carried out, especially when using analog SiPMs and ASICs. Hopefully, this thesis will motivate and enable many other novel design concepts, useful in PET instrumentation as well as it will serve as a helpful reference for similar attempts. The present PhD thesis is organized as follows. There is an introduction part composed by three detailed sections. We attempt to summarize here some of the knowledge related to PET imaging and especially with the technique of TOF-PET. Some very recent but still unpublished results are also presented and included in this part, aiming to support statements and theories. The second part of this thesis lists the four peer-reviewed papers that the candidate is including.
This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 695536). It has also been supported by the Spanish Ministerio de Economía, Industria y Competitividad under Grants No. FIS2014-62341-EXP and TEC2016-79884-C2-1-R. Efthymios Lamprou has also been supported by Generalitat Valenciana under grant agreement GRISOLIAP-2018-026.
Lamprou, E. (2021). Development and Performance Evaluation of High Resolution TOF-PET Detectors Suitable for Novel PET Scanners [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/162991
TESIS
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Möller, Björn. "Full frame 3D snapshot : Possibilities and limitations of 3D image acquisition without scanning." Thesis, Linköping University, Department of Electrical Engineering, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2857.
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An investigation was initiated, targeting snapshot 3D image sensors, with the objective to match the speed and resolution of a scanning sheet-of-light system, without using a scanning motion. The goal was a system capable of acquiring 25 snapshot images per second from a quadratic scene with a side from 50 mm to 1000 mm, sampled in 512×512 height measurement points, and with a depth resolution of 1 µm and beyond.
A wide search of information about existing 3D measurement techniques resulted in a list of possible schemes, each presented with its advantages and disadvantages. No single scheme proved successful in meeting all the requirements. Pulse modulated time-of-flight is the only scheme capable of depth imaging by using only one exposure. However, a resolution of 1 µm corresponds to a pulse edge detection accuracy of 6.67 fs when visible light or other electromagnetic waves are used. Sequentially coded light projections require a logarithmic number of exposures. By projecting several patterns at the same time, using for instance light of different colours, the required number of exposures is reduced even further. The patterns are, however, not as well focused as a laser sheet-of-light can be.
Using powerful architectural concepts such as matrix array picture processing (MAPP) and near-sensor image processing (NSIP) a sensor proposal was presented, designed to give as much support as possible to a large number of 3D imaging schemes. It allows for delayed decisions about details in the future implementation.
It is necessary to relax at leastone of the demands for this project in order to realise a working 3D imaging scheme using concurrent technology. One of the candidates for relaxation is the most obvious demand of snapshot behaviour. Furthermore, there are a number of decisions to make before designing an actual system using the recommendations presented in this thesis. The ongoing development of electronics, optics, and imaging schemes might be able to meet the 3D snapshot demands in a near future. The details of light sensing electronics must be carefully evaluated and the optical components such as lenses, projectors, and fibres should be studied in detail.
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Huang, Huan. "Optimizing Deposition of Matrix and Ionization Salt via Two-Step Sublimation in Sample Preparation for Surface-Layer Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging (SL-MALDI-TOF MSI)." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1619183035472425.
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Alokhina, Marharyta. "Design of the Cherenkov TOF whole-body PET scanner using GATE simulation." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS279/document.
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Dans cette thèse, nous présentons la conception et l’étude de performance d’un tomographe par émission de positrons (TEP) corps entier utilisant la radiation Cherenkov avec capacité de temps-de-vol (projet PECHE). Nos résultats et les conclusions sont basés sur la simulation GATE pour la configuration du scanner suivante: cristal de fluorure de plomb attaché à un photomultiplicateur à micro-canaux. C’est un cristal de haute densité, transparent pour les photons ultraviolet, et possède la fraction photoélectrique la plus élevé de 46%. Le photomultiplicateur choisi est un détecteur de grande taille, rapide et pixélisé avec une efficacité quantique raisonnable, de 25% à une longueur d'onde de 400 nm. Grâce à ces propriétés, il est possible d’envisager un détecteur efficace de gamma de 511 keV avec une épaisseur de cristal de 10 mm (une longueur d'interaction) et donc de minimiser la longueur et dispersion des trajectoires de photons, résultant à une résolution temporelle optimisée. Nous avons étudié les configurations différentes de détecteur élémentaire tels que le cristal avec les épaisseurs de 10 et 20 mm, le diamètre de l'anneau de détection de 80 et 90 cm, diverses options de le revêtement de cristal (noir, blanc diffus et poli) et deux interfaces optiques (collage moléculaire et assemblage conventionnel avec un gel optique). Pour une configuration optimale, nous avons choisi un scanner TEP à trois anneaux avec un diamètre de l'anneau de 80 cm, cristal de 10 mm d'épaisseur, et un blindage en plomb. Le collage moléculaire donne une meilleure photo-collection comparée à configuration avec un gel optique. Nous avons estimé le potentiel du scanner envisagé en utilisant les tests recommandés par la norme NEMA NU 2-2012. En particulier, nous avons évalué le taux de comptage de bruit équivalent (NECR), la résolution spatiale, coefficients de recouvrement de contraste de l'image et la variabilité de bruit de fond pour le fantôme de qualité d’image. La reconstruction des images est faite en utilisant l'algorithme itératif temps-de-vol implémenté dans la plate-forme de reconstruction « open source » CASToR récemment développée. Nous avons conclu qu’un scanner corps entier utilisant la lumière Cherenkov pourrait atteindre des performances comparables à celles d'un tomographe classique à scintillation grâce à son excellente résolution temps-de-vol. L'utilisation du rayonnement Cherenkov permet d'atteindre une résolution en temps-de-vol encore meilleure. Il est limité actuellement par la dispersion de temps de transit des photomultiplicateurs existants, un faible nombre de photons optiques détectés et une efficacité de collecte de photons dans un cristal limitée. Les limitations physiques identifiées dans cette étude seront abordées dans le développement du futur photodétecteur amélioré utilisant le radiateur PbWO₄, qui permet de concevoir un scanner TEP corps entier avec une excellente performance temps-de-volsIn this thesis we present the conception and performance studies of the foreseen Cherenkov whole-body positron emission scanner with time-of-flight potential (PECHE project). Our results and conclusions are based on the GATE simulation for following scanner configurations: lead fluoride crystal coupled with micro-channel-plate photomultiplier. This crystal is characterized by high density, transparency for photons in ultraviolet region, and one of the highest photoelectric fraction of about 46%. The chosen photomultiplier is fast, pixelized detector of a large size with a reasonable quantum efficiency, of 25% for 400 nm photon wavelength. Due to these properties, it is possible to create an efficient 511-keV gamma detector with a crystal thickness of the order of 10 mm(one interaction length) and hence minimize the length and dispersion of the photon trajectories, leading to better time resolution. We considered different configurations of the elementary detectors such as crystal thicknesses of 10 and 20 mm, the detector ring diameter of 80 and 90 cm, various options of the crystal coating (black, diffuse white and polished) and two optical interfaces (molecular bonding and conventional assembling with an optical gel). As an optimal configuration we chose a three-ring pet scanner with diameter of the ring 80 cm, 10 mm-thick crystal, protected with lead shielding. Molecular bonding gives better photo-collection if compare with configuration with optical gel. We estimated the potential of the foreseen scanner following the prescription of the NEMA NU 2-2012 standard. In particular, we evaluated the noise equivalent count rate (NECR), spatial resolution, image contrast recovery coefficients versus background variability for the NEMA image quality phantom. Reconstruction of images is done using iterative TOF algorithm implemented in the recently developed open source reconstruction platform CASToR. We concluded that due to an excellent TOF resolution a crystal-based Cherenkov whole-body scanner could achieve performances comparable with a conventional, scintillation-based tomograph. The use of the Cherenkov radiation allows to achieve even much better TOF resolution, but currently it is limited by the transit time spread of the existing photomultipliers, a low number of the detected optical photons, and a limited photon collection efficiency in a crystal. Limitations identified in this study will be addressed in the future development of the improved photodetector using the PbWO₄ radiator, which allows to conceive a whole-body PET scanner with an excellent TOF performance
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Mirus, Matthew M., Sergey V. Tokalov, Gerald Wolf, Jerilyn Heinold, V. Prochnow, and Nasreddin Abolmaali. "Noninvasive assessment and quantification of tumour vascularisation using MRI and CT in a tumour model with modifiable angiogenesis – An animal experimental prospective cohort study." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-232305.
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Background
To investigate vascular-related pathophysiological characteristics of two human lung cancers with modifiable vascularisation using MRI and CT.
Methods
Tumour xenografts with modifiable vascularisation were established in 71 rats (approval by the Animal Care Committee was obtained) by subcutaneous transplantation of two human non-small-cell lung cancer (NSCLC) cells (A549, H1299) either alone or co-transplanted with vascular growth promoters. The vascularity of the tumours was assessed noninvasively by MRI diffusion-weighted-imaging (DWI), T2-weighted, and time-of-flight (TOF) sequences) as well as contrast-enhanced CT (CE-CT), using clinical scanners. As a reference standard, histological examinations (CD-31, fluorescent beads) were done after explantation.
Results
Microvessel density (MVD) was higher in co-transplanted tumours (171 ± 19 number/mm2) than in non-co-transplanted tumours (111 ± 11 number/mm2; p = 0.002). Co-transplanted tumours showed higher growth rates and larger tumour vessels at TOF-MRI as well as larger necrotic areas at CE-CT. In co-transplanted tumours, DWI revealed higher cellularity (lower minimal ADCdiff 166 ± 15 versus 346 ± 27 mm2/s × 10−6; p < 0.001), highly necrotic areas (higher maximal ADCdiff 1695 ± 65 versus 1320 ± 59 mm2/s × 10−6; p < 0.001), and better-perfused tumour stroma (higher ADCperf 723 ± 36 versus 636 ± 51 mm2/s × 10−6; p = 0.005). Significant correlations were found using qualitative and quantitative parameters: maximal ADCperf and MVD (r = 0.326); maximal ADCdiff and relative necrotic volume on CE-CT (r = 0.551); minimal ADCdiff and MVD (r = −0.395).
Conclusions
Pathophysiological differences related to vascular supply in two human lung cancer cell lines with modifiable vascularity are quantifiable with clinical imaging techniques. Imaging parameters of vascularisation correlated with the results of histology. DWI was able to characterise both the extent of necrosis and the level of perfusion.
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Naik, Devang S. "Bose-Einstein Condensation: Building the Testbeds to Study Superfluidity." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-09072006-141453/.
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Thesis (Ph. D.)--Physics, Georgia Institute of Technology, 2007.Davidovic, Dragomir, Committee Member ; Kennedy, T.A. Brian, Committee Member ; Chapman, Mike, Committee Member ; Raman, Chandra, Committee Chair ; Bunz, Uwe, Committee Member.
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Le, Sellier Francois 1974. "Discrete real-time flight plan optimization." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/50629.
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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1999.Includes bibliographical references (leaves 117-118).
Worldwide, the continuously growing air traffic induces a need for new ATM concepts to be defined. One possibility is using a more decentralized system predicated mainly around free routings (Free Flight), for a more flexible management of airspace. The present study first highlights the discrepancies and inefficiencies of the current best flightplan optimizing software that use the Cost Index concept before departure. It then investigates techniques to perform enhanced flight-plan optimizations en-route, with algorithms that are less complex than using the Cost Index. The long-haul flight leg that is considered through the simulations is London (UK) - Boston (MA, USA), flown on a constant flight level. This study shows that running another optimization at the Top of Climb point reduces the average delay at destination from 6.9 minutes to 5.0 minutes. Then, the more futuristic method of considering discrete flight-plan optimizations, while en-route using updated weather forecasts, provides results that are more interesting. If the weather forecasts and the optimizations are done simultaneously every 3-hour or 1.5-hour, the average delay respectively becomes 2.6 minutes or 2.0 minutes. The second part of this work investigates ways of performing a Linear Program to fly a route close to a 4D-trajectory. This study provides ways of determining the exact weight values for the different state variables used in the cost function to minimize.
by Francois Le Sellier.
S.M.
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Pettersson, Lucas. "Localization with Time-of-Flight cameras." Thesis, KTH, Numerisk analys, NA, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273788.
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Time-of-Flight (ToF) cameras are becoming an increasingly common sensor in smartphones. These sensors are able to produce depth measurements in a grid at a relatively high rate. Using these depth measurements, point-clouds representing the captured scene can be produced. Previous research has been conducted in using ToF or LIDAR images to localize the camera. In this paper, we investigate several methods to localize the camera using point-clouds and surface meshes. Small alterations were made to some of the algorithms but the concepts remain the same. The main algorithms consisted of ICP variants as well as a relatively recent method called Corrective Gradient Refinement (CGR). The results obtained from generated data indicate that some of the methods are applicable for real-time applications, and the position estimates are comparable to those found in previous results.Time-of-flight (ToF)-kameror blir en allt vanligare sensor i mobiltelefoner. Dessa sensorer kan producera djupmätningar i ett rutnät med relativt hög frekvens. Med hjälp av dessa djupmätningar kan ett punktmoln som representerar den fångade scenen produceras. Tidigare forskning har gjorts med hjälp av ToF- eller LIDAR-bilder för att lokalisera kameran. Här undersöks flera metoder för att lokalisera kameran med hjälp av ett punktmoln och en triangulering av en modell. Algoritmerna bestod till största delen av ICP-varianter samt en relativt ny metod som heter Corrective Gradient Refinement (CGR). Resultaten som erhållits från genererade data indikerar att vissa av metoderna är lämplig för realtidsapplikationer och felet på positioneringen är jämförbart med dem som hittades i tidigare resultat.
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Kirmani, Ghulam A. (Ghulam Ahmed). "Computational time-resolved imaging." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/97803.
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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2015.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 151-159).
Classical photography uses steady-state illumination and light sensing with focusing optics to capture scene reflectivity as images; temporal variations of the light field are not exploited. This thesis explores the use of time-varying optical illumination and time-resolved sensing along with signal modeling and computational reconstruction. Its purpose is to create new imaging modalities, and to demonstrate high-quality imaging in cases in which traditional techniques fail to even form degraded imagery. The principal contributions in this thesis are the derivation of physically-accurate signal models for the scene's response to timevarying illumination and the photodetection statistics of the sensor, and the combining of these models with computationally tractable signal recovery algorithms leading to image formation. In active optical imaging setups, we use computational time-resolved imaging to experimentally demonstrate: non line-of-sight imaging or looking around corners, in which only diffusely scattered light was used to image a hidden plane which was completely occluded from both the light source and the sensor; single-pixel 3D imaging or compressive depth acquisition, in which accurate depth maps were obtained using a single, non-spatially resolving bucket detector in combination with a spatial light modulator; and high-photon efficiency imaging including first-photon imaging, in which high-quality 3D and reflectivity images were formed using only the first detected photon at each sensor pixel despite the presence of high levels of background light.
by Ghulam A. Kirmani.
Ph. D.
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Costello, Kevin Francis. "Laser desorption time-of-flight mass spectrometry." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/13475.
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The techniques of supersonic molecular beam cooling and laser multiphoton ionisation (MPI) spectroscopy have been combined to give a potentially powerful analytical technique. Two methods of sample introduction into the molecular beam have been employed, namely resistive heating and laser desorption. The resistive heating method allowed 2-colour MPI spectra of naphthalene, anthracene and perylene to be recorded in a simple free jet apparatus. A sensitivity for anthracene of 600 ppb is estimated. A time-of-flight (TOF) mass spectrometer has been developed, incorporating both linear and reflecting-geometry (reflectron) flight tubes, to allow laser desorption MPI (LD-MPI) mass spectra to be recorded for a number of involatile and thermally unstable compounds. Mass resolutions of 300 (linear) and 850 (reflectron) have been obtained for aniline. The constraints affecting the mass resolving power of both spectrometer designs are discussed. Finally, the potential of LD-MPI mass spectrometry as a sensitive, selective analytical technique is evaluated. The mass spectra of a number of polynuclear aromatic hydrocarbons, porphyrins and amino acids are presented, along with those of a simple mixture of the three aromatic amino acids tryptophan, tyrosine and phenylalanine. A sub-nanomole detection limit is estimated for tryptophan. Means to improve the sensitivity of the technique are discussed. The wider analytical applications of LD-MPI mass spectometry are considered.
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Von, Zuben Francis S. G., and Alfred S. Jr David. "TIME SYNCHRONIZATION IN FLIGHT TEST DATA ANALYSIS." International Foundation for Telemetering, 2000. http://hdl.handle.net/10150/608278.
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International Telemetering Conference Proceedings / October 23-26, 2000 / Town & Country Hotel and Conference Center, San Diego, CaliforniaA recurring problem in flight testing navigation systems is the need for an accurate, common time reference for the system under test and for the truth source to which it is compared. Lockheed Martin Aeronautics Company and Computer Sciences Corporation have developed software that utilizes all available timing information to reference the times of validity for each navigation measurement to Coordinated Universal Time. This permits accurate comparison and correlation of data necessary for statistical error analysis of the navigation system.
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Botling, Taube Amelie. "Molecular and epidemiological studies on eyes with pseudoexfoliation syndrome." Doctoral thesis, Uppsala universitet, Oftalmiatrik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-260714.
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Pseudoexfoliation (PEX) syndrome is an age-related condition characterized by the production and accumulation of extracellular fibrillary material in the anterior segment of the eye. PEX predisposes for several pathological conditions, such as glaucoma and complications during and after cataract surgery. The pathogenesis of PEX is not yet fully understood. It is multifactorial with genetics and ageing as contributing factors. We aimed to study the proteome in aqueous humor (AH) in PEX in order to increase the knowledge about its pathophysiology. Therefore, we developed sampling techniques and evaluated separation methods necessary for analyzing small sample volumes. Other objectives were to study the lens capsule in eyes with PEX regarding small molecules, and to investigate the association between PEX and cataract surgery in a population-based 30-year follow-up study. Samples of AH from eyes with PEX and control eyes were collected during cataract surgery. In pooled, and individual samples, various liquid based separation techniques and high resolution mass spectrometry were utilized. For quantitation, various methods for labeling, and label free techniques were applied. Lens capsules were collected from some of the patients, and analysed by imaging mass spectrometry. A cohort of 1,471 elderly individuals underwent a comprehensive ophthalmological examination at baseline. Medical information was obtained by questionnaires, and from medical records. Incident cases of cataract surgery were identified by review of medical records. In the initial study, several techniques were explored for protein detection, and a number of proteins were identified as differentially expressed. In the individually labelled samples, changes in the proteome were observed. Eyes with PEX contained higher levels of proteins involved in inflammation, oxidative stress, and coagulation, suggesting that these mechanisms are involved in the pathogenesis in PEX. The levels of β/γ-crystallins were significantly increased in PEX, which is a novel finding. In the lens capsules from individuals with PEX, changes in the lipid composition was observed with time-of-flight secondary ion mass spectrometry. These changes remain to be elucidated. By multivariate analysis, lens opacities were the first, and PEX the second most important predictor for cataract surgery, the later accounting for a 2.38-fold increased risk for cataract surgery.
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Lekpor, Kossi. "Time-varying filtering of time-of-flight mass spectra for proteomics." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81549.
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Proteomics is the post-genomic science that aims to identify and characterize the entire protein complement of a cell or organism. Mass spectrometry followed by database search is the core technology used in high-throughput protein identification. A major challenge in Proteomics is the random and chemical noise that corrupts mass spectra. This noise can alter the measured mass-to-charge ratio (m/z) and bias peak intensities, thus leading to errors in peptide ion peak detection. Thus, noise reduction by filtering is necessary prior to data analysis.As mass spectrometer response varies with m/z, an invariant filter would not be optimal; therefore, a time-varying filter was developed to denoise mass spectra. This involved conversion of spectra from the m/z domain to the time domain equivalent, modeling spectral peak shape and Fourier-transforming the model to determine its frequency content. The process was completed by filter design and implementation.
The application of this filter to experimental spectra resulted in improved signal-to-noise ratio (by factor of 45), enabled detection of low abundance peptide ions, and increased the accuracy of peptide mass assignment.
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Albani, David. "Constrained positron flight in PET imaging via strong magnetic fields." Connect to resource, 2008. http://hdl.handle.net/1811/32134.
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Baumann, Sandra [Verfasser], and Jürgen [Akademischer Betreuer] Hennig. "Time-of-flight-Magnetresonanzangiographie mit kontinuierlich bewegtem Patiententisch." Freiburg : Universität, 2011. http://d-nb.info/1123458413/34.
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Gilkerson, Paul. "Digital signal processing for time of flight sonar." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343467.
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Armitage, Nolan Jennifer Claire. "Time of flight mass spectrometry of pharmaceutical systems." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13701/.
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Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a widely used surface chemical analysis technique that is traditionally employed to characterise the first few molecular layers of a material interface. The ability of this technique to accurately reflect the surface chemistry of polymers, biomaterials and many other solid materials is well documented. However, the majority of research that utilises this technique is based upon a qualitative rather than quantitative assessment of the material under investigation. The qualitative analysis of a range of traditional tablet and bead formulations containing drug and multiple excipients was performed in order to identify key diagnostic ions for all the different components. The lateral distributions of the ions across the surfaces of these formulations were imaged. Two different methods were then used to perform a qualitative analysis of the surfaces and results from these experiments were compared to the bulk composition. The effect of surface roughness on the ability to produce reproducible quantitative analyses from ToF SIMS ion yield data was investigated. A range of samples with different topographies were studied including polytetrafluoroethylene (PTFE), glass microscope slides, gold coated abrasive papers and gold coated precision measurement samples. The surface roughness was assessed by Atomic Force Microscopy and Laser Profilometry. Samples were analysed in imaging mode and the variance in ionization across the total image was measured for each sample. Evidence is presented that there is a relationship between ion yield and surface roughness, and that the surface roughness of the analysed surfaces will effect on any quantification approach in the processing of ToF-SIMS data. In addition, the presence of any orientation/directionality in surface features also needs to be evaluated when considering use of a quantitative approach. To investigate the effect of chemical environment on the ability to derive quantitative data from ToF SIMS analysis of pharmaceutical materials, drug loaded spun cast polymer films with low surface roughness were studied. ToF SIMS data were obtained for two chemically similar drugs in two different polymer matrices. In the majority of the samples there was no quantitative relationship between drug ion intensity and nominal bulk composition. Due to the large sample set, the multivariate technique, Principal Component Analysis (PCA) was employed to look at variance in secondary ion yields from the different samples. PCA is becoming more prevalent in ToF-SIMS data interrogation as it allows for a mathematically un-biased analysis of sample variables through the identification of the ions that account for the majority of the variance in the sample set. PCA successfully highlighted the impact of the chemical environment, showing secondary ion yields of drugs can be dependent on the surrounding matrix. PCA was also used to look at variance in two of the tablet samples and was successfully able to differentiate between the tablet samples with the lowest and highest concentrations of paracetamol. This thesis has demonstrated that surface topography and surface chemical environment or matrix will have a significant impact on ion yields in the ToF-SIMS experiments. These findings suggest caution in the use of ToF-SIMS for the quantitative analysis of complex chemically heterogeneous and topographically diverse pharmaceutical formulations.
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Teerikoski, Sakari. "A prototype backscattering neutron time-of-flight spectrometer." Thesis, Uppsala universitet, Tillämpad kärnfysik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-256783.
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Measuring neutron energies is an essential task in fusion research. The time-of-flight (TOF) of neutrons moving a known distance can be used to determine these energies. Slower neutrons have longer TOFs for fix flight paths. Neutrons are slowed down when they backscatter. A prototype backscattered neutron TOF spectrometer is constructed so that two detectors D1 and D2 are placed on respective sides of a neutron source. The goal is to measure the TOF of neutrons from the source that reach D1 and backscatter and reach D2. There can, however, be lots of background events that will look like a false backscattering event. Scintillation detectors are used as detectors in the prototype and the neutrons are provided by a californium-252 source. Test results from a first prototype show unsatisfying time-of-flight spectra that are dominated by a large background peak, indicating that further work is required for getting measurement results of time-of-flight of backscattered neutrons. Some aspects of improving the results and the prototype are discussed. Test results from a second prototype do show satisfying spectra, although further work is needed to verify that the difference compared to earlier results is due to backscattered neutrons.Uppmätning av neutroners energier är av vikt inom kärnfusionsforskning. Flygtiden för neutroner som rör sig en känd sträcka kan användas för att bestämma dessa energier. För fixa flygsträckor gäller att långsammare neutroner har längre flygtider. Neutroner saktas ner när de bakåtsprids. En flygtidsspektrometerprototyp för bakåtspridda neutroner konstrueras så att två detektorer D1 och D2 placeras på respektive sidor om en neutronkälla. Målet är att mäta flygtiden för sådana neutroner från källan som når D1, bakåtsprids därifrån och till slut nåt D2. Det finns dock utrymme för många slags bakgrundsfenomen som ser ut som bakåtspridning men inte är det. Scintillatordetektorer används som prototypens detektorer och neutronerna ges av en californium-252 källa. Testresultat visar otillfredsställande flygtidsspektra som domineras av en stor bakgrundstopp. Detta indikerar att vidare arbete krävs för att få uppmätta flygtider för bakåtspridda neutroner. Vissa förslag för förbättring av resultaten och av prototypen diskuteras. Testresultat från en efterföljande prototyp ger tillfredsställande spektra. Dock behövs mera arbete med den nya prototypen för att verifiera att förändringen i resultaten verkligen beror på bakåtspridda neutroner.
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Kuball, Silke. "Emissionsdichteschätzung bei Time-of-Flight Positronen Emissions-Tomographie." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9935146.
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Heatherington, John. "ToF - the Time-of-Flight device for H1." Thesis, Queen Mary, University of London, 1995. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1502.
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Event triggering for the H1 detector on the HERA electron-proton ring is dominated by background associated with the proton beam. A 99% reduction in trigger rate is achieved by time resolution of background from physics using ToF -a scintillator detector positioned in the incoming proton direction. Studies on the efficiency of the veto have been carried out to improve background rejection.
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Grisham, Joe P. 1950. "Phase enhanced time-of-flight magnetic resonance angiography." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/46454.
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Davies, Stephen James. "Remote techniques for time-of-flight flaw characterisation." Thesis, University of Warwick, 1991. http://wrap.warwick.ac.uk/108293/.
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This thesis describes the investigations conducted into the characterisation of various defects within solids using laser - generation and interferometric detection of ultrasound. Laser - generated ultrasound has advantages over the more commonly used piezoelectric transducers in that it is a reproducible, wide bandwidth, non - contact source which, by using appropriate optics, can be focussed to a point or line source and easily scanned over a surface. Used in association with an interferometric detector enables the possibility of a remote inspection system which would be useful for some applications. The properties of such a system for the characterisation of both bulk and surface - breaking defects are ascertained. Part of the research project has been concerned with determining the properties of the ultrasound produced in various solids by different laser pulse profiles. The results obtained indicate that the risetime of the ultrasonic compression wave decreases with decreasing incident laser pulse risetime. However the mechanical and thermal properties of the irradiated solid also affects the risetime of the ultrasound. Modelling of the laser - solid interaction was undertaken to understand this phenomenon in more detail. The wide bandwidth nature of laser - generated ultrasound was used in the characterisation of bulk defects. This has involved determining, using an FFT algorithm, the phase change which occurs when laser - generated ultrasound is scattered from such defects. The aim of the investigation was to assess whether a particular type of defect has a unique phase change which will enable it to be classified. The experimental results obtained compared favourably with the results from theoretical modelling of ultrasonic scattering by defects. Finally the interaction of laser - generated Rayleigh ( surface ) waves with surface - breaking defects was considered. Various techniques for the characterisation of surface - breaking defects by analysis of data in the time and frequency domain were utilised. One such technique involved measurement of the Reflection and Transmission coefficients of various surface discontinuities. The phase change of the scattered Rayleigh wave was determined and compared to the theoretical data available. Also, a technique was established whereby certain features on the waveforms recorded on transmission of a Rayleigh wave through a surface - breaking defect could be used to determine the depth of the defect.
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Zou, Xiaoming. "Models to measure mobilities by time-of-flight /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486462702468012.
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Kegel, Thomas, and Bruce Lipe. "THE ADAPS REAL-TIME / POST FLIGHT PROCESSING SYSTEM." International Foundation for Telemetering, 1999. http://hdl.handle.net/10150/607324.
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International Telemetering Conference Proceedings / October 25-28, 1999 / Riviera Hotel and Convention Center, Las Vegas, NevadaThis paper describes the Real-Time/Post-Flight Processing System (RT/PFP) developed under the Air Force Flight Test Center (AFFTC) Advanced Data Acquisition and Processing Systems (ADAPS) development program. The RT/PFP is currently being deployed at all Range Division Mission Control Facilities as the principal Range Division telemetry processing system. This paper provides an overview of the RT/PFP system, its current capabilities, and future enhancements being developed. The RT/PFP is currently used to support the F-22 flight test program, and to provide telemetry processing support for the AFFTC Range Safety Office. The RT/PFP is also used in a mobile configuration to support the Advanced Fighter Technology Integration program.
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PATUREAU, Philippe, and Douglas ULLAH. "REAL TIME PRESENTATION FOR RAFALE IN-FLIGHT TESTS." International Foundation for Telemetering, 1991. http://hdl.handle.net/10150/612913.
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International Telemetering Conference Proceedings / November 04-07, 1991 / Riviera Hotel and Convention Center, Las Vegas, NevadaThe current control rooms at Dassault Aviation, Istres were built in 1978 for the flight tests of the MIRAGE 2000 GENERATION. After 13 years of gradual improvements, the time has come to renew our instrumentation. New concepts and future technologies have been taken into consideration and the new equipment that is implemented must allow flight tests to be performed throughout the current decade. These changes have occurred to enable testing of a new breed of combat aircraft, i.e. the RAFALE, for the coming years. However, this improvement is in keeping with what has already been achieved over the last 22 years at DASSAULT AVIATION. A brief background reminder will allow assessment of the company’s real time philosophy. A ground control room provides two types of displays, namely: # a decommutator controlled display for minimum refresh rates. It is concerned with flight monitoring and hence safety. # a second display is connected to the host computer dedicated to data handling during flight time. A more accurate description will show how a locally available item of equipment was customized to match specific requirements and to enhance its basic functionalities so as to make up the display chain needed for flight safety.
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Torbet, Tyler S. "Analysis of Synthetic Cannabinoids by Direct Analysis in Real Time Quadrupole Time-of-Flight Mass Spectrometry and Gas Chromatography Quadrupole Time-of-Flight Mass Spectrometry." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2216.
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The aim of this study was to investigate the utility of direct analysis in real time quadrupole time-of-flight mass spectrometry and gas chromatography quadrupole time-of-flight mass spectrometry in the analysis of 162 different synthetic cannabinoids. Direct analysis in real time quadrupole time-of-flight mass spectrometry is shown to be a rapid and accurate analytical method for synthetic cannabinoids. Spectra can be generated with less than 1.5 ng of the drug in under a minute and be successfully searched against previously generated ESI-QTOF libraries in most cases (118/130 drugs tested) as well as can also be applied to the identification of synthetic cannabinoids in a mixture. Gas chromatography quadrupole time-of-flight mass spectrometry, while requiring a much longer analysis time, is shown to accurately distinguish all but 19 compounds (140/159). These two instruments have proven to be viable alternatives in synthetic cannabinoid analysis and will greatly benefit forensic laboratories.
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Ates, Tugrul Kagan. "Real-time Arbitrary View Rendering From Stereo Video And Time-of-flight Camera." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612801/index.pdf.
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Generating in-between images from multiple views of a scene is a crucial task for both computer vision and computer graphics fields. Photorealistic rendering, 3DTV and robot navigation are some of many applications which benefit from arbitrary view synthesis, if it is achieved in real-time. Most modern commodity computer architectures include programmable processing chips, called Graphics Processing Units (GPU), which are specialized in rendering computer generated images. These devices excel in achieving high computation power by processing arrays of data in parallel, which make them ideal for real-time computer vision applications. This thesis focuses on an arbitrary view rendering algorithm by using two high resolution color cameras along with a single low resolution time-of-flight depth camera and matching the programming paradigms of the GPUs to achieve real-time processing rates. Proposed method is divided into two stages. Depth estimation through fusion of stereo vision and time-of-flight measurements forms the data acquisition stage and second stage is intermediate view rendering from 3D representations of scenes. Ideas presented are examined in a common experimental framework and practical results attained are put forward. Based on the experimental results, it could be concluded that it is possible to realize content production and display stages of a free-viewpoint system in real-time by using only low cost commodity computing devices.