Journal articles: 'Tissu de granulation excessif'

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NORWOOD, O'TAR T. "Excessive Granulation Tissue after Hair Transplantation." Journal of Dermatologic Surgery and Oncology 11, no. 6 (June 1985): 566. http://dx.doi.org/10.1111/j.1524-4725.1985.tb01895.x.

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Nordin, Peter C., Kjell S. Hersle, Wendela K. Liander, and Gösta A. Roupe. "Topical Potent Corticosteroids for Excessive Granulation Tissue." Dermatologic Surgery 25, no. 6 (June 1999): 517. http://dx.doi.org/10.1046/j.1524-4725.1999.09049.x.

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Gaudiello, Francesca, Massimiliano Scalvenzi, Lucia Gallo, and Nicola Balato. "Excess granulation tissue and hair loss following acitretin." Dermatology Reports 3, no. 1 (February 4, 2011): 2. http://dx.doi.org/10.4081/dr.2011.e2.

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Wakelin, S. H., and R. W. Emmerson. "Excess granulation tissue development during treatment with cyclosporin." British Journal of Dermatology 131, no. 1 (July 1994): 147–48. http://dx.doi.org/10.1111/j.1365-2133.1994.tb08482.x.

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VERSTRAETE, F. J. M., and A. J. LIGTHELM. "Excessive granulation tissue of periodontal origin in a horse." Equine Veterinary Journal 20, no. 5 (September 1988): 380–82. http://dx.doi.org/10.1111/j.2042-3306.1988.tb01551.x.

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Mandrea, Eugene. "Topical Diflorasone Ointment for Treatment of Recalcitrant, Excessive Granulation Tissue." Dermatologic Surgery 24, no. 12 (December 1998): 1409–10. http://dx.doi.org/10.1111/j.1524-4725.1998.tb00024.x.

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Moineau, A., L. Machet, M. Ackerman, E. Blanchard, C. Blechet, and A. Finon. "Erosive Plaques with Excessive Granulation Tissue on the Scalp: A Quiz." Acta Dermato Venereologica 100, no. 14 (2020): adv00208. http://dx.doi.org/10.2340/00015555-3567.

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Krishnaprasad, I. N., V. Soumya, and S. Abdulgafoor. "Management of Over-Granulation in a Diabetic Foot Ulcer: A Clinical Experience." Indian Journal of Physical Medicine and Rehabilitation 24, no. 1 (2013): 19–22. http://dx.doi.org/10.5005/ijopmr-24-1-19.

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Abstract Over-granulation or exuberant granulation tissue is a common problem encountered in the care of chronic wounds, especially that of diabetic foot ulcers. There are several potential options for the treatment of this challenging problem. Some have an immediate short term effect but may have a longer term unfavourable effect, for example, silver nitrate application and surgical excision, which may delay wound healing by reverting the wound back to the inflammatory phase of healing. Other products, such as foams and silver dressings may offer some effect in short term, but their long term effects are questionable. The more recent research supports Haelan cream and tape as an efficacious and cost effective treatment for over-granulation in a variety of wound types. The future of treating over-granulation may lie with surgical lasers, since lasers can not only remove over-granulation tissue but will also cauterise small blood vessels and are very selective, leaving healing cells alone while removing excess and unhealthy tissue. Recently Drs Lain and Carrington have demonstrated the utility of imiquimod, an immune-modulator with anti-angiogenic properties, in the treatment exuberant granulation tissue, in a patient with long standing diabetic foot ulcer, resistant to other forms of therapy. We adapted a modified version of their protocol in the management of a similar patient in our hospital and achieved a good result in lesser time than the former.

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Amaral, Lívia Gomes, Emily Correna Carlo Reis, Natália Alves Fernandes, Andrea Pacheco Batista Borges, Fabrício Luciani Valente, and Rodrigo Viana Sepulveda. "Biodegradable polymer nanofiber membrane for the repair of cutaneous wounds in dogs - two case reports." Semina: Ciências Agrárias 37, no. 6 (December 14, 2016): 4171. http://dx.doi.org/10.5433/1679-0359.2016v37n6p4171.

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The study of wound healing and its treatment is extremely important in veterinary medicine due to the high frequency of wounds and the difficulty in treating wounds by second intention. Thus, the objective of this study was to evaluate the use of a nanofiber membrane made of biodegradable polymers as a method of wound treatment in dogs. This study comprised two dogs with bite wounds. Debridement and cleaning was performed followed by the application of the membrane. In one dog, the wound was in the left proximal calcaneal region with clinical signs of infection, necrotic tissue, and muscle and the gastrocnemius tendon were exposed. The wound displayed rapid formation of granulation tissue which became excessive, so it was necessary to debride several times. However, with the suspension of the use of the membrane, formation of this tissue was not observed, and the wound evolved to epithelialization and fast contraction. In the second dog, there was a deep wound on the medial aspect of the proximal right hind limb, with clinical signs of infection, with muscle exposure. Once the membrane was placed, granulation tissue formed, and the membrane was used until the level of this tissue reached the skin. The wound underwent rapid epithelialization and contraction, without developing exuberant granulation tissue. Efficient wound repair was observed and the dogs exhibited greater comfort during application and use of the membrane. More studies should be conducted in dogs focusing on the application of this membrane until the appearance of healthy granulation tissue, as continued use seems to stimulate the formation of exuberant granulation tissue.

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Mcgrath, J., and O. Schofield. "Treatment of excessive granulation tissue with EMLA* cream and 95% silver-nitrate pencils." Clinical and Experimental Dermatology 15, no. 6 (November 1990): 468. http://dx.doi.org/10.1111/j.1365-2230.1990.tb02152.x.

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Dedar, Ramesh Kumar, Naveen Kumar, Shirish D. Narnaware, and Bhupendra Nath Tripathi. "Leaf Extract of Aerva javanica Suppresses Excessive Growth of Granulation Tissue in Horses." Journal of Equine Veterinary Science 93 (October 2020): 103193. http://dx.doi.org/10.1016/j.jevs.2020.103193.

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CASSY, S., S. DRIDI, and M. TAOUIS. "La leptine chez le poulet." INRAE Productions Animales 14, no. 3 (June 16, 2001): 161–69. http://dx.doi.org/10.20870/productions-animales.2001.14.3.3736.

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Chez les volailles, le contrôle du bilan énergétique représente un enjeu économique majeur dans la mesure où la sélection des espèces aviaires sur la vitesse de croissance s’est accompagnée d’un développement excessif de l’engraissement. Connue chez les mammifères pour son action sur le contrôle de la prise alimentaire et de la dépense énergétique, la leptine pourrait également jouer un rôle important dans le contrôle du bilan énergétique des volailles. Chez le poulet, la leptine est exprimée dans le tissu adipeux mais surtout dans le foie. Cette expression hépatique est probablement à mettre en relation avec le rôle joué par cet organe dans la lipogenèse chez les volailles. Comme chez les mammifères, la leptine reflète l’adiposité du poulet et l’expression de la leptine peut être régulée par l’état nutritionnel ou la composition du régime alimentaire. La leptine inhibe la prise alimentaire en agissant probablement sur des récepteurs situés au niveau de l’hypothalamus. Modulée par de nombreuses hormones impliquées dans le contrôle de la prise alimentaire et des réserves énergétiques, les effets de la leptine chez le poulet semblent être similaires à ceux décrits chez les mammifères.

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Shinozaki, Maki, Yuka Okada, Ai Kitano, Kazuo Ikeda, Shizuya Saika, and Masahiro Shinozaki. "Impaired cutaneous wound healing with excess granulation tissue formation in TNFα-null mice." Archives of Dermatological Research 301, no. 7 (June 20, 2009): 531–37. http://dx.doi.org/10.1007/s00403-009-0969-z.

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Štilet, Predrag, and Miloš D. Pavlović. "Periungual Pyogenic Granuloma-Like Lesions During Isotretinoin Treatment for Acne: Two Case Reports and a Literature Review." Serbian Journal of Dermatology and Venereology 7, no. 2 (June 1, 2015): 69–74. http://dx.doi.org/10.1515/sjdv-2015-0007.

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Abstract Periungual pyogenic granuloma-like lesions are not uncommon side effects of isotretinoin therapy, but these cases are relatively infrequently reported. Excessive granulation tissue appeared in two patients receiving oral isotretinoin therapy for severe acne. Once isotretinoin was discontinued, the outgrowths resolved spontaneously in both patients. It is probably an idiosyncratic reaction to isotretinoin which renders the skin more susceptible to extracellular matrix and blood vessel formation. Moreover, similar lesions may be observed particularly with newer targeted therapies, such as inhibitors of epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase kinases (MEKs). EGFR inhibitors associated painful periungual inflammation (paronychia), which often arises from the nail wall during newer targeted therapies, has been classified in the third major group of dermatologic toxicity. Cutaneous toxicity may be interpreted as a stress response that affects epidermal homeostasis. In the cell, stress signals are transmitted to effectors which then produce an inflammatory response. In conclusion, paronychia and excessive granulation tissue in the nail folds are not uncommon side effects of oral retinoids. It is therefore particularly important for practicing dermatologists to be aware that the best management approach is drug discontinuation.

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Udovichenko., О. V., A. Yu Tokmakova, M. B. Antsiferov, P. V. Yushkov, and I. I. Dedov. "Clinical and morphological features of reparative processes in patients with the diabetic foot syndrome." Problems of Endocrinology 49, no. 1 (February 15, 2003): 20–25. http://dx.doi.org/10.14341/probl11402.

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The purpose of the study was to examine structural abnormalities in the skin and granulation tissue, which explain long-term healing and recurrent trophic ulcers in patients with the neuropathic diabetic foot syndrome who received adequate treatment. Biopsy specimens were taken from the granulation tissue and skin of the edge of a trophic ulcer in 12 patients (mean age 48.4+6.6 years) with types 1 and 2 diabetes mellitus (its duration was 14.0+4. 7 years). All the patients were treated for the neuropathic diabetic foot syndrome according to the generally accepted recommendations. According to the duration of trophic ulcer, the patients were divided into 2 groups: 1) 4 patients with a history of under 3 months and 2) 8 patients with a history of above 3 months. According to the presence or absence of trophic ulcers in the history, all the patients were again divided into Groups A (recurrent ulcers, n = 5) and В (primary ulcers, n = 7). Patients with slowly healing ulcers were found to have an abnormal foot pressure more frequently, as evidenced by computerized pedography (the peak load in the ulcer area being in 63% of them versus 25% in Group 1) and some specific features of granulation tissue (excess of active fibroblasts, immaturity of the extracellular matrix, atrophy and sclerosis of nerve fibers). Patients with recurrent ulcers were older, demonstrated lower vibration perception scores, morphological features, such as abundant active polymorphonuclear leukocytes, mast cells with signs of degranulation and T-helper cells, immature extracellular matrix, fibrinoid necrosis and young capillary vessels with microthrombi. Thus, the detection of the above granulation tissue and wound edge changes (especially with an abnormal foot pressure pattern, significantly low vibration perception scale, and old age) makes it possible to suggest slow healing or recurrence of ulcer.

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Gou, Wenjun, Heng Li, Xu Yang, Bo Long, Yuyan Qiu, Haijun Kang, and Siyuan Liu. "Influence of Indwelling Lacrimal Drainage Tube on the Curative Effect of Endonasal Endoscopic Dacryocystorhinostomy." Journal of Biomaterials and Tissue Engineering 11, no. 6 (June 1, 2021): 1201–5. http://dx.doi.org/10.1166/jbt.2021.2718.

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Endonasal endoscopic dacryocystorhinostomy (EES-DCR) has gradually become the main surgical method for treating chronic dacryocystitis. Whether the placement of the lacrimal drainage tube during the operation can improve the operation’s success rate is an issue. This study observes the effect of an indwelling lacrimal drainage tube on the curative effect of EES-DCR in patients with chronic dacryocystitis. The cure rate of the Lacrimal duct drainage tube non-indwelling group A was 93.8% (46/49). The 3 cases failed because of the nasal cavity’s inflammation, which resulted in the adhesion of the anastomotic stoma and the middle turbinate. The cure rate of the Lacrimal drainage tube indwelling group B was 85.7% (42/49). The 7 cases failed because of the excessive proliferation of the tissue around the anastomosis, the hyperplasia of granulation tissue, the shedding of the lacrimal duct drainage tube, the crack of the lacrimal duct, and the premature removal of the lacrimal duct drainage tube caused the contraction of the mucosa around the anastomosis, resulting in the anastomosis obstruction. There was no obvious difference between the two groups (P > 0.05). At 6 months, 46 cases of the EES-DCR group A had gradually epithelialized anastomoses without granulation tissue growth with the follow up time extension. In the EES-DCR group B, 42 cases of anastomoses were gradually epithelialized without granulation tissue growth. Nasal endoscopic dacryocystorhinostomy combined with an indwelling lacrimal duct drainage tube can be used to treat chronic dacryocystitis, but an indwelling lacrimal duct drainage tube has no significant effect on the efficacy of chronic dacryocystitis.

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Takayama, Yoshiharu, and Reiji Aoki. "Roles of lactoferrin on skin wound healing1This article is part of Special Issue entitled Lactoferrin and has undergone the Journal's usual peer review process." Biochemistry and Cell Biology 90, no. 3 (June 2012): 497–503. http://dx.doi.org/10.1139/o11-054.

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Skin wound healing is a complex biological process that requires the regulation of different cell types, including immune cells, keratinocytes, fibroblasts, and endothelial cells. It consists of 5 stages: hemostasis, inflammation, granulation tissue formation, re-epithelialization, and wound remodeling. While inflammation is essential for successful wound healing, prolonged or excess inflammation can result in nonhealing chronic wounds. Lactoferrin, an iron-binding glycoprotein secreted from glandular epithelial cells into body fluids, promotes skin wound healing by enhancing the initial inflammatory phase. Lactoferrin also exhibits anti-inflammatory activity that neutralizes overabundant immune response. Accumulating evidence suggests that lactoferrin directly promotes both the formation of granulation tissue and re-epithelialization. Lactoferrin stimulates the proliferation and migration of fibroblasts and keratinocytes and enhances the synthesis of extracellular matrix components, such as collagen and hyaluronan. In an in vitro model of wound contraction, lactoferrin promoted fibroblast-mediated collagen gel contraction. These observations indicate that lactoferrin supports multiple biological processes involved in wound healing.

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Anikin, I. A., S. A. Eremin, and A. E. Shinkareva. "Method for the prevention of inflammatory processes in the bone part of the external auditory canal accompanied by the growth of connective tissue." Russian Otorhinolaryngology 19, no. 4 (2020): 21–26. http://dx.doi.org/10.18692/1810-4800-2020-4-21-26.

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Otosurgery plays an important role in the rehabilitation of patients with hearing loss. Any operation can be accompanied by a long inflammatory process with excessive development of connective tissue, forming atresia or stenosis of the external auditory canal. Formed scars in the external auditory canal reduce the effectiveness of treatment and can lead to reoperation. In the treatment of scars, the use of injections of a suspension of prolonged steroids directly into the developing connective tissue is effective. We have developed a method of injecting drugs into the scar tissue of the bone section of the external auditory canal, which allows the use of such therapy in patients after otosurgery. 12 people were treated with the proposed technique. All patients had an inflammatory process in the external auditory canal with undesirable growth of connective tissue. Previous local therapy did not bring a satisfactory result. Patients received injections of a suspension of steroids into developing scar tissue. The treatment period was 1-8 weeks, for which 1 to 4 sessions of injections were performed. As a result of treatment according to the developed method, in all cases a cessation of the pathological inflammatory process was observed. Timely therapy made it possible to completely eliminate the excess granulation tissue (100%), to stop the growth of the scar, or even to cause a significant decrease (33%). The developed method allows to use of a small dose of a substance (0,1–0,5 ml) for injection to achieve the desired therapeutic effect.

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Gaafar, A. A., A. A. El-Daly, and H. A. Gaafar. "Laryngotracheal augmentation using titanium mesh." Journal of Laryngology & Otology 122, no. 4 (May 14, 2007): 391–96. http://dx.doi.org/10.1017/s0022215107008109.

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AbstractBackground:The management of laryngotracheal stenosis is still a serious surgical challenge. The fact that there are currently numerous reconstruction procedures indicates that there is at present no standard treatment.Study design:Titanium mesh was used instead of traditional homografts in reconstruction of the anterior laryngotracheal wall in 12 tracheostomised patients with benign chronic laryngotracheal stenosis. The anterior laryngotracheal wall was split, followed by excision of scar tissue and fixation of the titanium plate at the split end. A Silastic®stent was inserted above the tracheostomy tube and fixed in place by running sutures fixed to the skin by buttons. The stent was removed endoscopically six weeks later and a trial of decannulation was undertaken.Results:Endoscopically, good epithelisation was seen on the inner surface of the mesh in 10 cases and decannulation was possible. Four of these patients required endoscopic debulking of granulation tissue. Decannulation was impossible in two cases, one due to excessive granulation tissue and the other due to prolapse of the titanium mesh into the tracheal lumen (the mesh was removed endoscopically and a Montgomery T-tube inserted).Conclusion:Titanium mesh was found to be a good alternative for augmentation of the anterior laryngotracheal wall. It offered rigid support, with fewer of the complications reported with other grafts.

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Yu, Bo, Jia-Ying Sun, Qian Ye, Yun-Hai Tu, Guang-Ming Zhou, and Wen-Can Wu. "Surgical outcomes in acute dacryocystitis patients undergoing endonasal endoscopic dacryocystorhinostomy with or without silicone tube intubation." International Journal of Ophthalmology 14, no. 6 (June 18, 2021): 844–48. http://dx.doi.org/10.18240/ijo.2021.06.08.

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AIM: To establish the necessity of silicone tube intubation in acute dacryocystitis (AD) patients undergoing endonasal endoscopic dacryocystorhinostomy (En-DCR). METHODS: Patients presenting with unilateral AD were randomly assigned to two treatment groups. En-DCR procedures were performed following lacrimal abscess formation, with the operation being performed with silicone intubation for patients in group B but not group A. Functional success was defined by an absence of additional AD episodes, no epiphora, and ostium patency as established via endoscopic evaluation or fluorescein irrigation. Operative success rates and demographic variables were compared between treatment groups. RESULTS: In total, 66 patients were analyzed in the present study (33 per group), with complete postoperative data having been successfully collected from 27 and 22 patients in group A and group B, respectively. All patients exhibited complete resolution of acute inflammation. Upon follow-up, granulation tissue was detected around the ostium at higher rates in group B (9/22, 40.9%) relative to group A (4/27, 14.8%). At the 12-month follow-up time point, patients in group A exhibited higher success rates (25/27, 92.6%) relative to patients in group B (20/22, 90.9%), but this difference was not significant. Cases of lacrimal passage reconstruction failure in both groups were attributed to excessive fibrous and/or granulation tissue formation proximal to the intranasal ostium. CONCLUSION: Given that these two operative approaches are associated with similar rates of operative success and in light of differences in granulation tissue formation, cost, and operative duration, these data do not support the routine silicone intubation of AD patients following En-DCR surgery.

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Azeez, Arshad, N. S. Venkatesh, and T. Shivakumar. "Analysis of outcome of diabetic foot ulcer following topical phenytoin and betadine use: a comparative study." International Surgery Journal 4, no. 4 (March 25, 2017): 1263. http://dx.doi.org/10.18203/2349-2902.isj20171009.

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Background: Diabetic ulcer is the major cause of morbidity and excess hospital care cost for the patients with diabetes and most frequent reason for hospitalization in patients. Diabetic foot ulcers precede almost 85% of amputations in India. Though there are many modes for care of the wound, treating diabetic wounds are still an enormous problem. Aim of the study was to analyse the outcome of topical phenytoin dressing as compared to conventional wound dressing in diabetic ulcers and thus to know if phenytoin is a better and cheaper alternative option in the management of diabetic ulcersMethods: A sample of 90 patients were selected using purposive sampling technique. Of which 45 underwent topical phenytoin dressings, remaining 45 underwent conventional wound care. Daily dressing was done for 14 days and then was subjected to split skin grafting. The variables were compared based on rate of granulation tissue formation, graft uptake & duration of hospital stay. The categorical variable was compared by chi square test and continuous variable by student t-test. A p value <0.05 was considered significant.Results: In Phenytoin group, mean rate of granulation tissue formation was 92.51%. Mean graft up-take was 92.98% and mean hospital stay was 35.68 days. In Conventional group, mean rate of granulation formation was 83.31%. The Mean graft up-take was only 78.09%, mean hospital stay was 47.31 days.Conclusions: Topical phenytoin helps in faster healing of the diabetic ulcer and better graft up-take and reduces hospital stay.

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Dayanir, Volkan, Ahmet Kaplan, and Ozlem Polatli. "Excessive granulation tissue at the harvest site following pterygium surgery with conjunctival autograft: a clinicopathological case report." Clinical & Experimental Ophthalmology 37, no. 4 (May 2009): 415–17. http://dx.doi.org/10.1111/j.1442-9071.2009.02056.x.

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DaudÉn, E., M. Pascual-LÓpez, C. MartÍnez-GarcÍa, and A. GarcÍa-DÍez. "Paronychia and excess granulation tissue of the toes and finger in a patient treated with indinavir." British Journal of Dermatology 142, no. 5 (May 2000): 1063–64. http://dx.doi.org/10.1046/j.1365-2133.2000.03509.x.

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Eze, N., and G. A. Morrison. "Difficult airway in a child with severe dystonia." Journal of Laryngology & Otology 127, no. 4 (February 25, 2013): 438–39. http://dx.doi.org/10.1017/s0022215113000224.

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AbstractObjective:To describe the management of a 15-year-old girl with repeated life-threatening complications of her tracheostomy secondary to muscle dystonia and thoracolumbocervical lordosis.Method:This paper reports a retrospective case review.Results:Regular microlaryngoscopy and bronchoscopy, treatment with systemic steroids and a soft tracheostomy tube, in addition to better control of the dystonia, resulted in control of the patient's airway. This minimised tracheal inflammation and granulation tissue formation.Conclusion:The need for a tracheostomy in patients with thoracolumbocervical lordosis and severe dystonia should be considered only after all other options of airway management have been explored. Every attempt should be made to minimise tracheal trauma caused by excessive movement of a tracheostomy tube.

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Yang, Shu-Fang, Heng-Leng Yang, Sao-Ling Liang, and Peng-Chen Wang. "CASE REPORT: SUBCONJUNCTIVAL INJECTION WITH AUTOLOGOUS PLATELET-RICH PLASMA FOR REFRACTORY CORNEAL ULCERS IN A DOG." Taiwan Veterinary Journal 44, no. 04 (December 2018): 211–16. http://dx.doi.org/10.1142/s1682648518720034.

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A 12-year-old, intact, male Golden Retriever dog presented with a 1-month history of corneal ulcer, redness, and occasional squint in the left eye (oculus sinister [OS]). A thorough ophthalmological examination revealed corneal edema, diffuse corneal vascularization, and excessive granulation tissue growth. The tentative diagnosis was chronic superficial keratitis or pannus. After 3 weeks of treatment for OS, blepharospasm and superficial corneal ulceration with a lip of nonadherent epithelium of the right eye (oculus dexter [OD]) developed. No improvement was observed after autologous serum eye drop treatment combined with simple debridement and grid keratotomy on both eyes (oculi uterque [OU]) for 3 months; thereafter, blindness developed. The diagnosis was refractory corneal ulcers. The application of autologous platelet-rich plasma (PRP) was instilled via subconjunctival injection OU every 2 weeks for 2 months. The OU corneas started to re-epithelialize and heal, and the granulation tissues significantly decreased while the vision improved. Therefore, PRP was continued to be administered every 1–2 months for 6 months. After more than 1 year, the OU corneas have healed without recurrent ulceration and with only mild haze. In conclusion, autologous PRP subconjunctival injection is a potentially beneficial addition to the medical management of refractory corneal ulcers in dogs.

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Nickerson, Duncan, and Arnis Freiberg. "Moisture-Retentive Dressings: A Review of the Current Literature." Canadian Journal of Plastic Surgery 3, no. 1 (March 1995): 35–38. http://dx.doi.org/10.1177/229255039500300107.

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Moisture-retentive dressings allow rapid epithelialization, reduce pain, reduce fibrosis, reduce infection and yield better cosmetic results. Furthermore, occlusive dressings allow less painful debridement and stimulate granulation tissue. Despite these advantages, moisture-retentive dressings are still underused. Among the reasons for this underuse are confusion due to the variety of dressings available, fear of infection, and excessive cost. The studies reviewed here refute concerns that moisture-retentive dressings are associated with more infections or that they are too expensive to be practical. The issue of cost was addressed in several of the articles reviewed here, and while moisture-retentive dressings are certainly more expensive on a per unit basis, their overall cost-effectiveness can be more favourable than other more conventional dressings.

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SAGREN, M., and P. M. MERTZ. "Are excessive granulation tissue formation and retarded wound contraction due to decreased collagenase activity in wounds in tight-skin mice?" British Journal of Dermatology 131, no. 3 (September 1994): 337–40. http://dx.doi.org/10.1111/j.1365-2133.1994.tb08520.x.

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Liu, Jenny, Phillip T. Hsu, Beth A. VanderWielen, and Joyce M. Teng. "Treatment of Recalcitrant Excessive Granulation Tissue with Photodynamic Therapy in an Eight-Year-Old Patient with Focal Dermal Hypoplasia Syndrome." Pediatric Dermatology 29, no. 3 (October 13, 2011): 324–26. http://dx.doi.org/10.1111/j.1525-1470.2011.01436.x.

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MOUROT, J. "Mise en place des tissus adipeux sous-cutanés et intramusculaires et facteurs de variation quantitatifs et qualitatifs chez le porc." INRAE Productions Animales 14, no. 5 (December 17, 2001): 353–63. http://dx.doi.org/10.20870/productions-animales.2001.14.5.3761.

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Le choix de la matière première lipidique dans l’alimentation du porc est particulièrement important. Il est bien connu qu’il existe une relation entre la nature des acides gras ingérés et ceux qui vont se déposer dans le tissu adipeux et à un degré moindre dans le muscle. Ce choix va donc conditionner la qualité de la viande. Des études récentes laissent aussi apparaître un rôle important du taux et de la nature des acides gras alimentaires sur la mise en place et le développement des tissus adipeux chez le fœtus lors de la gestation. Chez la truie, l’accroissement du taux de lipides alimentaires augmente l’adiposité de la carcasse du porcelet à la naissance et favorise la prolifération des précurseurs adipocytaires qui, par la suite, donneront les adipocytes. Un taux excessif de lipides alimentaires durant la gestation peut donc à terme induire une adiposité plus élevée chez le porc charcutier. L’origine des acides gras intervient également sur ces mêmes paramètres. L’huile de coprah, comparée à celle de tournesol et au saindoux semble stimuler la prolifération adipocytaire avec toutes les conséquences que ceci peut avoir sur l’obésité future du porc. Toutefois un mode d’alimentation restreint chez le porc en croissance semble minimiser ces conséquences. Chez le porc en croissance, l’accroissement du taux de lipides dans l’alimentation semble favoriser les dépôts de lipides dans les tissus adipeux. Une source de matière grasse insaturée, particulièrement riche en acide linoléique, favorise le potentiel de synthèse des lipides et peut donc accroître l’adiposité de la carcasse. Ces matières grasses insaturées ayant aussi des conséquences sur la qualité technologique des tissus adipeux, on ne peut qu’en recommander une utilisation raisonnable au cours de la croissance et si possible éviter de les incorporer aux aliments des porcs au-delà de 70 kg de poids vif pour un abattage à 105-110 kg.

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Ferreira, Marcus Castro, Alexandre Wada, and Paulo Tuma Jr. "The vacuum assisted closure of complex wounds: report of 3 cases." Revista do Hospital das Clínicas 58, no. 4 (2003): 227–30. http://dx.doi.org/10.1590/s0041-87812003000400008.

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Treatment of wounds using conventional methods is frequently limited by inadequate local wound conditions, or by a poor systemic clinical situation. Vacuum system may promote faster granulation tissue formation, remove excessive exudate, increase blood flow in the wound, and attract the borders of the wound to the center, reducing its dimension. We present 3 cases of patients with difficult wounds, due to bad local conditions, or poor clinical situation, in whom we used a vacuum system to prepare the wound for the surgical closure. One patient had a pressure ulcer, another had a diabetic foot ulcer, and the third one had an open foot stump. In the 3 cases a significant improvement of the wound conditions was achieved after 7 to 8 days, allowing successful surgical treatment with flap or skin grafts.

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Lipe, Kristin A., Lauren Michelle Fishbein, Janice M. Kerr, Samy A. Youssef, Kevin O. Lillehei, Margaret E. Wierman, B. K. Kleinschmidt-Demasters, and Katja Kiseljak-Vassiliades. "Clinical Correlation to E-cadherin and Granulation Patterns in Corticotroph Tumors." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A519. http://dx.doi.org/10.1210/jendso/bvab048.1059.

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Abstract Corticotroph adenomas, either secretory or silent, are associated with significant disease persistence and/or recurrence. Surgical resection is the first line treatment; however, recurrence rates range from 30 to 60%. Although several clinical parameters (i.e. postoperative cortisol level, tumor invasion) have been reported to predict tumor recurrence, none have high diagnostic accuracy. Granulation pattern classifies corticotroph tumors as densely granulated (DG) or sparsely granulated (SG) types, with the latter usually larger and more aggressively behaving. E-cadherin, a calcium-dependent adhesion molecule strongly expressed in normal pituitary cells, plays a role in epithelial cell behavior, tissue development, and suppresses epithelial-mesenchymal transition. Since loss of E-cadherin expression in sparsely granulated somatotroph pituitary tumors correlates with a more aggressive disease course, we sought to examine correlation between E-cadherin expression and behavior in densely versus sparsely granulated corticotroph tumors. A retrospective chart review of adult patients with corticotroph adenomas, seen at our institution between January 2012 - 2020 yielded 62 patients: 18 (29%) male and 44 female (71%), with median age at diagnosis of 49 years (range 25-82). Inclusion criteria required sufficient tissue for E- cadherin immunostaining (IHC). Microadenomas were identified in 19/62 (31%) patients, and 38/62 (52%) patients had clinical and biochemical findings consistent with excess cortisol secretion. Pre-operative imaging showed that 22/62 (35%) tumors were invasive into surrounding structures. After further classification as to densely granulated (DG) or sparsely granulated (SG) types by ACTH granulation pattern on IHC, 19/56 (34%) adenomas were SG, 37/56 (66%) were DG and 6 were not classified. E-cadherin staining was absent in 7/62 tumors (11%) and diminished in 5/62 (8%) tumors and staining did not correlate with dense versus sparse corticotroph types. Chi-squared analysis found a significant association between tumor size (greater than or less than 1cm) and secretion, with hormonally active more likely tumors to be microadenomas (p=0.004). Microadenomas were exclusively DG tumors (p<0.001). Further analysis did not find correlation between presence or absence of E-cadherin expression and tumor invasion into adjacent structures, or recurrence. In summary, the data suggests that, unlike somatotroph corticotroph adenomas for recurrence or invasion, nor does it correlate strongly with granulation status.

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Demarco, Ricardo, Alex Strose, Marcos Araújo, Fabiana Cardoso Pereira Valera, Iracema Moribe, and Wilma Terezinha Anselmo-Lima. "Endoscopic Revision of External Dacryocystorhinostomy." Otolaryngology–Head and Neck Surgery 137, no. 3 (September 2007): 497–99. http://dx.doi.org/10.1016/j.otohns.2007.03.023.

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OBJECTIVES: To observe the benefit of endoscopic surgery for the treatment of lacrimal duct obstruction in revisional surgeries after external dacryocystorhinostomy. STUDY DESIGN AND SETTING: Retrospective nonrandomized study. Eleven cases of recurrent lacrimal duct obstruction after external dacryocystorhinostomy were submitted to endoscopic dacryocystorhinostomy. RESULTS: The rate of success after revisional surgery was 90.9%. The major causes of failure of the external approach were the presence of granulation tissue, septal deviations and synechiae near the opening of the fistula, inadequate removal of the bony wall adjuvant the lacrimal sac, technical error in the localization of the lacrimal sac, and excessive perioperative bleeding that impaired the surgical field. CONCLUSION: Endoscopic dacryocystorhinostomy in revisional cases proved to be a safe technique of low morbidity, permitting effective resolution of the lacrimal obstructions. SIGNIFICANCE: Endoscopic surgery allows greater visibility of the lacrimal sac and its neighbor anatomic alterations and leads to better results.

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Ramachandran, Biggs Saravanan, Bright Thomas, Shana Baby, and Rosamma Thomas. "Multicentric ameboma of the colon mimicking Crohn℉s disease." Journal of Digestive Endoscopy 06, no. 02 (April 2015): 076–78. http://dx.doi.org/10.4103/0976-5042.159245.

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AbstractEntamoeba histolytica infection can lead to colitis, colonic perforation abscess, and ameboma formation. Amebic colitis is common in developing countries, with its varied and nonspecific symptoms. Amebomas can occur rarely due to the formation of excess granulation tissue which usually occurs in cecum and ascending colon. A 64-year-old lady presented with abdominal pain and mass in the right side of abdomen. Imaging showed multicentric colonic masses. On colonoscopy multiple stricturizing ulcerated lesions involving cecum, ascending, proximal transverse colon, and splenic flexure were seen, which were suggestive of Crohn′s disease or multicentric neoplasm. Histopathological examination revealed multicentric lesion with focal necrosis and trophozoites of E. histolytica. Diagnosis of ameboma was made and antiamoebic treatment was started. She had full resolution of symptoms. We present this case since it is a case of ameboma, a rare complication of amebic colitis with an extremely rare presentation of multiple ulcerated stricturizing lesions, involving cecum, ascending, transverse colon, and splenic flexure which typically resembled Crohn′s disease.

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García-Honduvilla, Natalio, Alberto Cifuentes, Miguel A. Ortega, Marta Pastor, Garazi Gainza, Eusebio Gainza, Julia Buján, and Melchor Álvarez-Mon. "Immuno-modulatory effect of local rhEGF treatment during tissue repair in diabetic ulcers." Endocrine Connections 7, no. 4 (April 2018): 584–94. http://dx.doi.org/10.1530/ec-18-0117.

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Wound healing is a complex process that can be severely impaired due to pathological situations such as diabetes mellitus. Diabetic foot ulcers are a common complication of this pathology and are characterized by an excessive inflammatory response. In this work, the effects of local treatment with recombinant human epidermal growth factor (rhEGF) were studied using a full-thickness wound healing model in streptozotocin-induced diabetic rats. Wound healing process was assessed with different concentrations of rhEGF (0.1, 0.5, 2.0 and 8.0 µg/mL), placebo and both diabetic and non-diabetic controls (n = 53). The macroscopic healing observed in treated diabetic rats was affected by rhEGF concentration. Histologically, we also observed an improvement in the epithelialization, granulation tissue formation and maturation in treated groups, finding again the best response at doses of 0.5 and 2.0 µg/mL. Afterwards, the tissue immune response over time was assessed in diabetic rats using the most effective concentrations of rhEGF (0.5 and 2.0 µg/mL), compared to controls. The presence of macrophages, CD4+ T lymphocytes and CD8+ T lymphocytes, in the reparative tissue was quantified, and cytokine expression was measured by quantitative real-time PCR. rhEGF treatment caused a reduction in the number of infiltrating macrophages in the healing tissue of diabetic, as well as diminished activation of these leukocytes. These findings show that local administration of rhEGF improves the healing process of excisional wounds and the quality of the neoformed tissue in a dose-dependent manner. Besides, this treatment reduces the local inflammation associated with diabetic healing, indicating immuno-modulatory properties.

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Martins, William Del Conte, Denis Steiner, Arthur Borges Neto, Salviano Tramontin Belettin, Carla Faria Orlandini, André Giarola Boscarato, Igor Bueno Volpato, and Luiz Romulo Alberton. "Graft of Small Patch of Partial Thickness in Equine Wound." Acta Scientiae Veterinariae 46 (January 13, 2018): 7. http://dx.doi.org/10.22456/1679-9216.85126.

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Background: Cutaneous wounds in locomotor limbs represent one of the most frequent disorders in equine medicine. Wounds in equines are distinguished from those in other species by unique characteristics, including different healing rates among breeds, wound location and high propensity to formation of exuberant granulation tissue during the healing process. The wound healing process that cannot be sutured can be accelerated by the use of skin grafts, lowering the treatment cost.The objective of this report was to divulgate the success upon treatment of an extensive lacerated wound in the metatarsal region of a horse using autologous skin grafts.Case: A 3-year-old, female, American quarter horse weighting 450 kg was brought to veterinary hospital with lower limb injury. According to the owner’s report, the animal had one of its limbs stuck in a plain wire fence. A wound was observed in the metatarsal region during physical examination, the lesion caused an extensive skin laceration that showed the dorsal surface of the metatarsal bone and the digital extensor tendon. After injury assessment, wound debridement was carried out by surgery intervention followed by antisepsis and application of autologous plasma every two days as post-surgical care and wound preparation to receive the graft. Forty-five days after the first intervention, grafts were collected from the neck and implanted in the wound. The procedure achieved 70% of success. After approximately 75 days, transplantation was performed in other regions of the wound using the same technique. The duration of treatment at the Veterinary Hospital of the Universidade Paranaense (UNIPAR) was eight months, and then the animal returned home, where dressings were applied for two months to avoid the risk of contamination and until complete recovery.Discussion: The debridement of the wound and edges approximation were of great value in order to begin the process of wound granulation. The established therapy with scarring with gauze and use of antiseptics only in the initial stages of treatment, the frequent exchange of bandages every two days, preventing the accumulation of exudate and the use of autologous plasma favored the formation of the granulation bed and was sufficient to avoid infection and the formation of exuberant granulation tissue. Factors such as excessive movement and local infection were also attributed as responsible for the longer healing period, so the use of the spring coupled to the horseshoe decreased the joint movement, proving tobe effective in patients with severe extensor tendon lacerations. The use of the spring coupled to the horseshoe promoted a correct biomechanical alignment and no walking complication or deficiency was observed. The correct anatomical structural positioning prevents the formation of flexural deformities and fibrosis of the joint capsule. The use of micrografts wasbeneficial and simple to perform and the use of grafts contributed to a better cosmetic result. The main factor contributed to the grafting success was the use of dressing, which was regularly changed, and topical antimicrobial therapy correctly applied to avoid contamination. Based on the clinical result of this patient, it was concluded that the use of small autologous grafts can provide good recovery and healing of extensive wounds in horses when proper care with dressings and antimicrobial medication is provided after surgical interventions.Keywords: equine, surgery, graft, healing.

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Wang, Lu, Barbara Belisle, Mansour Bassiri, Ping Xu, Dmitri Debabov, Chris Celeri, Nichole Alvarez, et al. "Chemical Characterization and Biological Properties of NVC-422, a Novel, StableN-Chlorotaurine Analog." Antimicrobial Agents and Chemotherapy 55, no. 6 (March 21, 2011): 2688–92. http://dx.doi.org/10.1128/aac.00158-11.

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ABSTRACTDuring oxidative burst, neutrophils selectively generate HOCl to destroy invading microbial pathogens. Excess HOCl reacts with taurine, a semi-essential amino acid, resulting in the formation of the longer-lived biogenerated broad-spectrum antimicrobial agent,N-chlorotaurine (NCT). In the presence of an excess of HOCl or under moderately acidic conditions, NCT can be further chlorinated, or it can disproportionate to produceN,N-dichlorotaurine (NNDCT). In the present study, 2,2-dimethyltaurine was used to prepare a more stableN-chlorotaurine, namely,N,N-dichloro-2,2-dimethyltaurine (NVC-422). In addition, we report on the chemical characterization,in vitroantimicrobial properties, and cytotoxicity of this compound. NVC-422 was shown effectively to kill all 17 microbial strains tested, including antibiotic-resistantStaphylococcus aureusandEnterococcus faecium. The minimum bactericidal concentration of NVC-422 against Gram-negative and Gram-positive bacteria ranged from 0.12 to 4 μg/ml. The minimum fungicidal concentrations againstCandida albicansandCandida glabratawere 32 and 16 μg/ml, respectively. NVC-422 has anin vitrocytotoxicity (50% cytotoxicity = 1,440 μg/ml) similar to that of NNDCT. Moreover, our data showed that this agent possesses rapid, pH-dependent antimicrobial activity. At pH 4, NVC-422 completely killed bothEscherichia coliandS. aureuswithin 5 min at a concentration of 32 μg/ml. Finally, the effect of NVC-422 in the treatment of anE. coli-infected granulating wound rat model was evaluated. Treatment of the infected granulating wound with NVC-422 resulted in significant reduction of the bacterial tissue burden and faster wound healing compared to a saline-treated control. These findings suggest that NVC-422 could have potential application as a topical antimicrobial.

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Hossain, Muhammad Rajib, Kazi Mazharul Islam, and Junaid Nabi. "Myiasis as a Rare Complication of Male Circumcision: A Case Report and Review of Literature." Case Reports in Surgery 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/483431.

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Introduction. Circumcision is a common procedure carried out around the world. Due to religious reasons, it is routinely done in Bangladesh, by both traditional as well as medically trained circumcisers. Complications include excessive bleeding, loss of foreskin, infection, and injury to the glans penis. Myiasis complicating male circumcision appears to be very rare.Case Presentation. In 2010, a 10-year-old boy presented to the OPD of Dhaka Medical College Hospital with severe pain in his penile region following circumcision 7-days after. The procedure was carried out by a traditional circumciser using unsterilized instruments and dressing material. After examination, unhealthy granulation tissue was seen and maggots started coming out from the site of infestation, indicating presence of more maggots underneath the skin. An emergency operation was carried out to remove the maggots and reconstruction was carried out at the plastic surgery department.Conclusion. There is scarcity of literature regarding complications following circumcision in developing countries. Most dangerous complications are a result of procedure carried out by traditional circumcisers who are inadequately trained. Incidence of such complications can be prevented by establishing a link between the formal and informal sections of healthcare to improve the safety of the procedure.

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Casiano, Roy A., Michael Patete, and Todd Lindquist. "Tracheoplasty Using Titanium Reconstructive Plates with Strap-Muscle Flap." Otolaryngology–Head and Neck Surgery 111, no. 3P1 (September 1994): 205–10. http://dx.doi.org/10.1177/01945998941113p108.

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The reasons for unsuccessful decannulation after a laryngotracheoplasty may be multifactorial depending on the techniques used. Excessive granulation tissue may develop, necessitating further adjunctive procedures. Cartilaginous grafts may get infected, resorb, or collapse into the tracheal lumen. Bulky regional skin-muscle flaps may dehisce under tension or collapse into the tracheal lumen. Medial migration of the split ends of the anterior cartilaginous tracheal rings ensues with subsequent restenosis. Donor-site morbidity may compound these problems as well. During a 2.5-year period, we have performed laryngotracheoplasty on nine patients with 60% to 100% tracheal stenosis using titanium reconstruction plates. The split anterior tracheal wall is fixed by the plates in its expanded position. A neurovascularized strap-muscle flap is used to reconstruct the anterior tracheal wall. The flap becomes epithelialized with squamous epithelium within 3 weeks. Successful decannulation was possible in seven of the nine (78%) patients with no further respiratory problems. Of these, six required no further procedures. This technique offers a viable simple alternative to other methods of laryngotracheoplasty without the need for donor cartilage grafts or thick bulky Skin-muscle flaps.

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Kulkarni, Ganesh P., and Ashwini S. Handal. "Comparative study of endonasal dacryocystorhinostomy with and without adjunctive topical use of Mitomycin C." International Journal of Research in Medical Sciences 5, no. 7 (June 24, 2017): 3208. http://dx.doi.org/10.18203/2320-6012.ijrms20173014.

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Background: Endoscopic dacryocystorhinostomy has now established itself in the treatment of lacrimal obstruction. Failures in endoscopic dacryocystorhinostomy are mainly due to reclosure of the stoma in the lateral nasal wall. Mitomycin-C is an alkylating agent used in the chemotherapy of various cancers. Mitomycin-C when topically applied to mucosal tissues has been reported to inhibit excessive scar tissue and granulation tissue formation, resulting in greater success rates.Methods: To evaluate the efficacy of Mitomycin-C in preventing reclosure of the dacryocystorhinostomy stoma, we performed a prospective, randomized case control study between November 2013 and October 2015. The study was conducted at tertiary care centre. The study sample consisted of 50 patients, who were randomly assigned to two groups, Group A which received the application of Mitomycin-C topically to the dacryocystorhinostomy stomal site and Group B which did not receive this intervention. The patients were regularly followed up for 6 months.Results: 24 patients (96%) out of 25 in the Group A, had a successful surgical outcome. In Group B 23 patients (92%) out of 25 were symptom free after surgery. These results indicated no statistically significant difference between the two groups (p>0.05). Hence the results of this study did not show any significant benefit for the use of Mitomycin-C as an adjunct during primary endoscopic dacryocystorhinostomy.Conclusions: An atraumatic and meticulous surgical technique along with a good follow up care post-operatively establishes endoscopic dacryocystorhinostomy as an effective treatment modality for chronic dacryocystitis.

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Ścierski, Wojciech, Grażyna Lisowska, Grzegorz Namysłowski, Maciej Misiołek, Jan Pilch, Elżbieta Menaszek, Radosław Gawlik, and Marta Błażewicz. "Reconstruction of Ovine Trachea with a Biomimetic Composite Biomaterial." BioMed Research International 2018 (October 17, 2018): 1–9. http://dx.doi.org/10.1155/2018/2610637.

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The aim of this study was to evaluate a novel composite material for tracheal reconstruction in an ovine model. A polymer containing various forms of carbon fibers (roving, woven, and nonwoven fabric) impregnated with polysulfone (PSU) was used to create cylindrical tracheal implants, 3 cm in length and 2.5 cm in diameter. Each implant, reinforced with five rings made of PSU-impregnated carbon-fiber roving, had three external layers made of carbon-fiber woven fabric and the inner layer formed of carbon-fiber nonwoven fabric. The inner surface of five implants was additionally coated with polyurethane (PU), to promote migration of respiratory epithelium. The implants were used to repair tracheal defects (involving four tracheal rings) in 10 sheep (9-12 months of age; 40-50 kg body weight). Macroscopic and microscopic characteristics of the implants and tracheal anastomoses were examined 4 and 24 weeks after implantation. At the end of the follow-up period, outer surfaces of the implants were covered with the tissue which to various degree resembled histological structure of normal tracheal wall. In turn, inner surfaces of the prostheses were covered only with vascularized connective tissue. Inner polyurethane coating did not improve the outcomes of tracheal reconstruction and promoted excessive granulation, which contributed to moderate to severe stenosis at the tracheal anastomoses. The hereby presented preliminary findings constitute a valuable source of data for future research on a tracheal implant being optimally adjusted for medical needs.

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Barreiros, Hugo, Diogo Matos, João Goulão, Pedro Serrano, Alexandre João, and Francisco Menezes Brandão. "Using 80% trichloroacetic acid in the treatment of ingrown toenails." Anais Brasileiros de Dermatologia 88, no. 6 (December 2013): 889–93. http://dx.doi.org/10.1590/abd1806-4841.20132296.

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BACKGROUND: Ingrown nails are a very common problem. There are different stages of disease and diverse therapeutic options. Phenol and sodium hydroxide are commonly used agents for chemical matricectomy but both frequently entail excessive healing times. OBJECTIVE: This prospective study aimed mainly to evaluate the efficacy of partial nail avulsion and selective chemical cauterization of the matrix using 80% TCA in the treatment of the ingrowing nail. METHODS: One-hundred-and-thirty-three patients with 197 ingrown toenails were included in this study. Preoperatively, we tried to find predisposing factors to the disease. In the postoperative period, patients were evaluated for potential complications at days 3, 30, 180, 270 and 360. Pain was measured before surgery, as well as 24 hours and 72 hours after surgery. RESULTS: There were only 3 cases (out of 197) of ingrown nail recurrence. Preoperatively, we found the presence of drainage in 82% of patients, which, following the first visit after surgery, was reduced to 19%. Persistent granulation tissue was found in 3% of the patients (versus 75% prior to surgery). The most frequent predisposing factors for the ingrown nail were excessive trimming of the lateral nail plate (63%), plantar hyperhidrosis (58%) and heavy nail folds (39%). Pain was substantially reduced after surgery. CONCLUSION: It is assumed that chemical procedures for the ingrown toenail are associated with delayed healing times but our results demonstrated quick recovery. Using 80% TCA for selective matricectomy in the ingrown toenail is an effective, quick and easy method.

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Demyanenko, Ilya A., Vlada V. Zakharova, Olga P. Ilyinskaya, Tamara V. Vasilieva, Artem V. Fedorov, Vasily N. Manskikh, Roman A. Zinovkin, et al. "Mitochondria-Targeted Antioxidant SkQ1 Improves Dermal Wound Healing in Genetically Diabetic Mice." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/6408278.

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Oxidative stress is widely recognized as an important factor in the delayed wound healing in diabetes. However, the role of mitochondrial reactive oxygen species in this process is unknown. It was assumed that mitochondrial reactive oxygen species are involved in many wound-healing processes in both diabetic humans and animals. We have applied the mitochondria-targeted antioxidant 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to explore the role of mitochondrial reactive oxygen species in the wound healing of genetically diabetic mice. Healing of full-thickness excisional dermal wounds in diabetic C57BL/KsJ-db−/db− mice was significantly enhanced after long-term (12 weeks) administration of SkQ1. SkQ1 accelerated wound closure and stimulated epithelization, granulation tissue formation, and vascularization. On the 7th day after wounding, SkQ1 treatment increased the number of α-smooth muscle actin-positive cells (myofibroblasts), reduced the number of neutrophils, and increased macrophage infiltration. SkQ1 lowered lipid peroxidation level but did not change the level of the circulatory IL-6 and TNF. SkQ1 pretreatment also stimulated cell migration in a scratch-wound assay in vitro under hyperglycemic condition. Thus, a mitochondria-targeted antioxidant normalized both inflammatory and regenerative phases of wound healing in diabetic mice. Our results pointed to nearly all the major steps of wound healing as the target of excessive mitochondrial reactive oxygen species production in type II diabetes.

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Kreft, Sandra, Andreas R. Klatt, Julia Straßburger, Ernst Pöschl, Rod J. Flower, Sabine Eming, Chris Reutelingsperger, Alain Brisson, and Bent Brachvogel. "Skin Wound Repair Is Not Altered in the Absence of Endogenous AnxA1 or AnxA5, but Pharmacological Concentrations of AnxA4 and AnxA5 Inhibit Wound Hemostasis." Cells Tissues Organs 201, no. 4 (2016): 287–98. http://dx.doi.org/10.1159/000445106.

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Skin injury induces the cell surface exposure of phosphatidylserine (PS) on damaged and dying cells to activate coagulation and repair processes. Annexins can bind to PS and may modulate the healing response. Here, we determine the relevance of annexins for skin wound healing using AnxA1- and AnxA5-deficient mice and recombinant annexins with distinct PS binding properties. Wound inflammation, closure and the formation of granulation tissue were not altered in AnxA1- or AnxA5-deficient mice or after increasing AnxA5 serum concentrations (100 nM) in wild-type mice. Increased serum concentrations (1 µM) of AnxA5 induced massive bleeding, but wound hemostasis was not delayed by AnxA1. Both annexins interact with PS, but only AnxA5 can form 2-dimensional (2D) arrays on the cell surface. The injection of an AnxA5 mutant that binds to PS but lacks the ability of 2D array formation failed to induce bleeding. 2D lattice-forming AnxA4, with high affinity to PS also caused bleeding, while hemostasis was not affected by AnxA8 with low affinity or the AnxA8 mutant with medium affinity for PS and the lack of 2D formation. Increased concentrations of AnxA4 and AnxA5 also delayed coagulation pathway activation in vitro. This effect was attenuated for the AnxA5 mutant as well as for AnxA1 and AnxA8. In conclusion, endogenous AnxA1 and AnxA5 are dispensable for wound hemostasis and repair, but pharmacologically excessive concentrations of AnxA4 and AnxA5 inhibit hemostasis in skin wounds.

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Koli, Davinder, Pravin Kumar, Viraj Panda, and Manu Vats. "Evaluation of the role of cyanoacrylate glue in the management of fistula-in-ano." International Surgery Journal 7, no. 3 (February 26, 2020): 721. http://dx.doi.org/10.18203/2349-2902.isj20200811.

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Background: Fistula in ano is a common problem in patients presenting to surgical OPD. Various procedures have been described for the treatment of anal fistula, including fistulectomy, fistulotomy and use of a cutting seton. Surgical treatment of anal fistula is associated with a significant risk of recurrence and faecal incontinence due to damage to anal sphincter. The introduction of cyanoacrylate glue to close fistula tracts using an occlusive material and with no risk of incontinence (as there is no sphincter damage). The study was designed to evaluate the role of cyanoacrylate glue in the management of fistula in ano.Methods: Here, 40 patients were enrolled in study as day cases. Patients were examined clinically and subjected to MRI pelvis where internal opening couldn’t be palpated on digital rectal examination (DRE). Fistula tract was mapped using fistula probe and washed with diluted hydrogen peroxide and normal saline. The excess granulation tissue at the external opening was curetted. The glue was then injected slowly into fistulous tract through 8 F infant feeding tube. Patients were further examined in the OPD until 6-months.Results: Here, 32 patients got healed after first instillation of glue with stoppage of discharge from the fistulous tract. The other 2 patients required second instillation of glue and showed no signs of discharge thereafter. While 6/40 continued to discharge even after instillation of glue.Conclusions: Cyanoacrylate glue can be offered as a sphincter sparing alternative to conventional procedure in patients with anal fistula.

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Wang, Ying-Piao, Mao-Che Wang, Yu-Chun Chen, Yi-Shing Leu, Hung-Ching Lin, and Kuo-Sheng Lee. "The effects of Vaseline gauze strip, Merocel, and Nasopore on the formation of synechiae and excessive granulation tissue in the middle meatus and the incidence of major postoperative bleeding after endoscopic sinus surgery." Journal of the Chinese Medical Association 74, no. 1 (January 2011): 16–21. http://dx.doi.org/10.1016/j.jcma.2010.09.001.

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Benjamin, Tabowei I., and Amaefula `Temple Ejike. "Ingrown toe nail as seen in Bayelsa state Nigeria." International Journal of Advances in Medicine 4, no. 3 (May 23, 2017): 614. http://dx.doi.org/10.18203/2349-3933.ijam20172258.

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Background: Ingrown toenails are common conditions of the foot causing pain, disability, and absence from work. It has been associated with use of tight foot wears, congenital anomalies of nail folds, nail plates, and medial rotation of the great toes; other predisposing factors include diabetes, obesity and cardiac disorders. It can be diagnosed clinically, and treatments include use of antibiotics analgesia and surgery. When untreated it may be complicated by sepsis, ulceration of nail fold and excessive granulation tissue formation osteomyelitis, gangrene of the leg.Methods: We observed an increase in the number of patients visiting our clinic with ingrown toe nails, and with no known work done on this subject in our environment we therefore conducted a questionnaire based prospective study between the periods January 2014 to June 2016 to determine the pattern of presentation, predisposing factors and treatment outcome. The data collected was analyzed using SPSS Version 20 for windows.Results: Twenty-eight (28) patients with age range 9 to 65 years, and mean age of 32, and male: female ratio of 2.1:1 were reviewed. The highest incidence was seen between the ages of 11 to 40 year old, and among students 8 (28.57%). Prevalence of 28.57% (n=8) was highest in those who wore tight/short shoes. The commonest presenting complains were pain, swelling (edema) and suppuration, with most patients 10 (35.71%) being seen in the clinic between 5-6 months of development symptoms. Ingrown toenails occurred statistically significantly more in the right big toe 13 (46.43%) [χ2 (p-value) = 19.43 (0.001). Amongst those whose anatomical site was at the right big toe, the Lateral aspect was 9 (69.23%).Conclusions: Most patients received Analgesics and Antibiotics and twenty one, 21(75%) of the patients had wedge resection and surgical destruction of the nail matrix.

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Rajshekar, MM. "Dacryocystorhinostomy Stent Insertion in Initial Endoscopic Dacryocystorhinostomy." An International Journal Clinical Rhinology 9, no. 3 (2016): 120–24. http://dx.doi.org/10.5005/jp-journals-10013-1284.

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ABSTRACT Aim To study surgical outcome in dacryocystorhinostomy (DCR) stent insertion in initial endoscopic DCR and the complications associated with the surgery. Study design This is a prospective, single-blinded, randomized, controlled trial. Materials and methods The study was carried in a tertiary level center (period between November 2009 and February 2015). A total of 50 patients with epiphora due to nasolacrimal duct obstruction were divided randomly into two groups – with one group undergoing endoscopic DCR with stent and the other group undergoing endoscopic DCR without stent. The postoperative results were assessed subjectively and objectively after 3 and 6 months and also for complications of the procedure. The results were statistically analyzed by chi-square test. Results There was significant postoperative improvement across all participants and within both groups. A total of 92% of patients in the stent group and 84% of patients in the without stent group improved. There was no significant difference with respect to complications. Synechiae and secondary hemorrhage were the most common complications in the without stent group and stent group respectively. Conclusion The present study shows that statistically significant difference in results is not achieved by inserting stents initially. But, whenever there is excessive bleeding during surgery, which masks endoscopic picture, or when bony stoma created is small because of thick bone and poor access, when atrophic sac is present, or when adhesions are expected due to pus in sac, then stenting should be done without hesitancy. Best time to do stenting is when surgeons’ first think of stenting. Regular postoperative follow-up is necessary as any defect like synechia and granulation tissue formation can be dealt with immediately. How to cite this article Rao SVM, Rajshekar MM. Dacryocystorhinostomy Stent Insertion in Initial Endoscopic Dacryocystorhinostomy. Clin Rhinol An Int J 2016;9(3):120-124.

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Huang, Zhenjie, Peng Wei, Luoman Gan, Tonghua Zeng, Caicheng Qin, and Guangnan Liu. "Role of Erythromycin-Regulated Histone Deacetylase-2 in Benign Tracheal Stenosis." Canadian Respiratory Journal 2020 (January 21, 2020): 1–10. http://dx.doi.org/10.1155/2020/4213807.

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Objective. This study aims to explore the role of erythromycin-regulated histone deacetylase-2 in benign tracheal stenosis. Methods. The rabbit model of tracheal stenosis was established. The rabbits were randomly divided into 8 groups. Histone deacetylase-2 (HDAC2) expression was detected by immunofluorescence. The expression of type I collagen and type III collagen was detected by immunohistochemical method. The expression of TGF-β1, VEGF and IL-8 in serum and alveolar lavage fluid was detected by ELISA. The expression of HDAC2, TGF-β1, VEGF and IL-8 in bronchi of each group was detected by Western blotting method. Results. In Erythromycin (ERY) group, ERY + Budesonide group, ERY + Vorinostat group and ERY + Budesonide + Vorinostat group, the degree of bronchial stenosis was alleviated, and the mucosal epithelium was still slightly proliferated. The effect of ERY combined with other drugs was more obvious. The HDAC2 protein expression increased significantly in ERY group, ERY + Budesonide group and ERY + Budesonide + Vorinostat group and decreased significantly in Vorinostat group, the expression of collagen I and III decreased significantly in ERY group, ERY + Budesonide group and ERY + Budesonide + Vorinostat group (P<0.05). The TGF-β1, IL-8 and VEGF levels decreased significantly in ERY group, ERY + Budesonide group, ERY + Vorinostat group and ERY + Budesonide + Vorinostat group (P<0.05). Conclusions. Erythromycin inhibited inflammation and excessive proliferation of granulation tissue after tracheobronchial mucosal injury by up-regulating the expression of HDAC2, it promoted wound healing and alleviated tracheobronchial stenosis. When combined with budesonide, penicillin and other glucocorticoids and antibiotics, it had a good synergistic effect. However, vorinostat could attenuate erythromycin’s effect by down-regulating the expression of HDAC2. It may have good clinical application prospects in the treatment of tracheal stenosis.

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Hoffman, Maureane, Angie Lenkowski, Jacqueline Brock, Ulla Hedner, and Dougald M. Monroe. "Delayed Wound Healing in Hemophilia B Mice." Blood 106, no. 11 (November 16, 2005): 3199. http://dx.doi.org/10.1182/blood.v106.11.3199.3199.

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Abstract These studies use our previously reported wound healing model to establish the mechanisms behind the impaired wound healing we observed in hemophilia B animals. We hypothisized that thrombin mediated signals generated in response to the initial wound would be absent or reduced in hemophilia B mice, leading to an impaired course of wound healing and poor angiogenesis. All work was done in accord with the US Amended Animal Welfare Act and was monitored by the Institutional Animal Care and Use Committee of UNC. Three mm circular dermal wounds were made in normal and hemophilia B mice. All wounds were treated with an antibiotic gel at the time the wound was made. The mice were monitored for bleeding both at the time the wound was made and for delayed bleeding. Hemophilia B mice with excessive bleeding were treated. The wounds were monitored for regrowth of the epithelial layer. The size of the area not covered by epithelial tissue was measured and expressed as square millimeters (wound size). We have previously reported that there is a significant difference in the time to wound healing between untreated hemophilic (10 days) and normal animals (7 days). At the end of the time course, wound areas were excised and the skin was formalin fixed, paraffin embedded, and sectioned. Essentially all hemophilia but no normal animals showed unresolved subcutaneous hematoma. During the wound healing process, macrophage infiltration into the granulation tissue was significantly delayed. Unexpectedly, hemophilia B mice relative to wild type mice showed twice as many blood vessels in the healing wound. This difference persisted out to two weeks after the wound was made and well after reepithelialization. Pretreatment (30 minutes prior to wounding) of hemophilia B mice with a single bolus dose of human factor IX sufficient to give 1 U/mL corrected the wound healing time. Pretreated hemophilia B mice did not have obvious subcutaneous hematomoas. The observation that a single bolus dose of factor IX prior to wounding a hemophilia B animal normalized the wound healing time provides a starting point for determining how different doses or different administration times effect wound healing. It also provides a starting point from which to compare the effects of bypassing therapy on wound healing.

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Firth, E. C., W. F. Hunt, and S. G. Pearce. "Evaluation of a Method for Biopsy of the Distal Radial Physeal Growth Plate in Neonatal Foals." Veterinary and Comparative Orthopaedics and Traumatology 12, no. 03 (1999): 128–33. http://dx.doi.org/10.1055/s-0038-1632477.

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SummaryA technique was devised for taking biopsies from the distal radial physeal growth plate in neonatal foals to study cartilage morphology. The biopsy taken from the right forelimb of 21 Thoroughbred foals, four to 10 days of age, was performed under inhalation anaesthesia, using a 9 mm diameter trephine on a multi speed drill. Due to their exercise not being adequately restricted postoperatively, five foals (24%) developed excessive incisional granulation tissue at the biopsy site. Nine foals (43%) developed some flexion of the carpus (over at the knee) and 15 (71%) developed outward rotation of the left limb. There was significantly greater carpal valgus in the left limb when compared with the right limb (p <0.005), a situation which was not present in six agematched, unoperated, control foals. Abnormalities in the congruency of the antebrachiocarpal joint were not detected grossly at postmortem at five months of age. However, there were localised gross and histological abnormalities of the distal radial physeal growth plate. Postoperative morbidity, significant changes to conformation, and the unknown long term consequences of the disruption to the biopsied physeal growth plate are likely to make this procedure inappropriate for clinical usage. However, the biopsy procedure was easy to perform, and provided a suitable sample for both histological and histomorphometric examination of the physeal growth plate cartilage. Therefore this technique provides a useful research method for study of growth plate morphology in neonates.A technique was developed for biopsy of the distal radial physeal growth plate in neonatal foals. Additionally, the effects on conformation, and on gross and histological abnormalities at five months of age, were reported. There were significant, mild conformational abnormalities, which self-corrected without intervention, and there were abnormalities detected at postmortem examination, but these abnormalities did not appear to affect the joint. The expected effects of this procedure are stated, and provided that these are accounted for, the technique is useful for harvesting and studying the physeal growth plate of neonates.

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Journal articles on the topic 'Tissu de granulation excessif'

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