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Journal articles on the topic 'Tissu vasculaire'

Author: Grafiati

Published: 7 September 2022

Last updated: 31 July 2025

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1

Andreelli, Fabrizio. "Risque cardio-vasculaire et tissu adipeux épicardique." Médecine des Maladies Métaboliques 2, no. 2 (2008): 166. http://dx.doi.org/10.1016/s1957-2557(08)70428-0.

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Alessi, Marie-Christine, Corinne Frère, and Irène Juhan-Vague. "Substances produites par le tissu adipeux, obésité et risque vasculaire." La Presse Médicale 34, no. 11 (2005): 820–24. http://dx.doi.org/10.1016/s0755-4982(05)84051-5.

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Bouloumié, A., M. Lafontan, and D. Langin. "Les cellules de la fraction stroma-vasculaire du tissu adipeux humain: caractérisation et rôles." Obésité 1, no. 2-4 (2006): 79–86. http://dx.doi.org/10.1007/s11690-006-0019-3.

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4

Nseir, I., F. Delaunay, C. Latrobe, A. Bonmarchand, D. Coquerel-Beghin, and I. Auquit-Auckbur. "Apport du tissu adipeux et de la fraction vasculaire stromale en chirurgie de la main." Revue de Chirurgie Orthopédique et Traumatologique 103, no. 6 (2017): 643–48. http://dx.doi.org/10.1016/j.rcot.2017.06.013.

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Nseir, Iad, Isabelle Auquit Auckbur, Dorothée Coquerel Beghin, Albane Bonmarchand, Flore Delaunay, and Charles Latrobe. "Apport du tissu adipeux et de la fraction vasculaire stromale en chirurgie de la main." Hand Surgery and Rehabilitation 35, no. 6 (2016): 485–86. http://dx.doi.org/10.1016/j.hansur.2016.10.193.

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Thery, A., P. Blery, O. Malard, J. Guicheux, P. Weiss, and F. Espitalier. "Apport de la fraction vasculaire stromale du tissu adipeux associée à un biomatériau dans la reconstruction osseuse en territoire irradié." Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale 130, no. 4 (2013): A109. http://dx.doi.org/10.1016/j.aforl.2013.06.343.

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Mwamengele, G. L. M., and S. Larsen. "L’ultrastructure de lamicrovasculature cérébrale de chèvres infectées expérimentalement avec Cowdria ruminantium." Revue d’élevage et de médecine vétérinaire des pays tropicaux 46, no. 1-2 (1993): 245. http://dx.doi.org/10.19182/remvt.9372.

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Afin d’étudier les lésions de la microvasculature cérébrale dans la cowdriose, 14 chèvres tanzaniennes ont été infectées par inoculation intraveineuse avec le stock Ball-3 de Cowdria ruminantium. Elles ont été suivies sur le plan clinique pendant la période d’incubation et la réaction fébrile, et sacrifiées lorsque les températures ont commencé à baisser. Cinq chèvres saines ont été utilisées pour déterminer la meilleure procédure pour la fixation du cerveau par perfusion et pour servir de témoins. La perfusion a été effectuée par l’artère carotide sous anesthésie générale au pentobarbitone, u

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Sigdel, Smara, Gideon Udoh, Rakan Albalawy, and Jinju Wang. "Perivascular Adipose Tissue and Perivascular Adipose Tissue-Derived Extracellular Vesicles: New Insights in Vascular Disease." Cells 13, no. 16 (2024): 1309. http://dx.doi.org/10.3390/cells13161309.

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Perivascular adipose tissue (PVAT) is a special deposit of fat tissue surrounding the vasculature. Previous studies suggest that PVAT modulates the vasculature function in physiological conditions and is implicated in the pathogenesis of vascular diseases. Understanding how PVAT influences vasculature function and vascular disease progression is important. Extracellular vesicles (EVs) are novel mediators of intercellular communication. EVs encapsulate molecular cargo such as proteins, lipids, and nucleic acids. EVs can influence cellular functions by transferring the carried bioactive molecule

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Sexton, Zachary A., Dominic Rütsche, Jessica E. Herrmann, et al. "Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing." Science 388, no. 6752 (2025): 1198–204. https://doi.org/10.1126/science.adj6152.

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Our ability to produce human-scale biomanufactured organs is limited by inadequate vascularization and perfusion. For arbitrarily complex geometries, designing and printing vasculature capable of adequate perfusion poses a major hurdle. We introduce a model-driven design platform that demonstrates rapid synthetic vascular model generation alongside multifidelity computational fluid dynamics simulations and three-dimensional bioprinting. Key algorithmic advances accelerate vascular generation 230-fold and enable application to arbitrarily complex shapes. We demonstrate that organ-scale vascular

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Meiliana, Anna, and Andi Wijaya. "Perivascular Adipose Tissue and Cardiometabolic Disease." Indonesian Biomedical Journal 5, no. 1 (2013): 13. http://dx.doi.org/10.18585/inabj.v5i1.46.

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BACKGROUND: Obesity is associated with insulin resistance, hypertension, and cardiovascular disease, but the mechanisms underlying these associations are incompletely understood. Microvascular dysfunction may play an important role in the pathogenesis of both insulin resistance and hypertension in obesity.CONTENT: Perivascular adipose tissue (PVAT) is a local deposit of adipose tissue surrounding the vasculature. PVAT is present throughout the body and has been shown to have a local effect on blood vessels. The influence of PVAT on the vasculature changes with increasing adiposity. PVAT simila

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Gui, Liqiong, and Laura E. Niklason. "Vascular tissue engineering: building perfusable vasculature for implantation." Current Opinion in Chemical Engineering 3 (February 2014): 68–74. http://dx.doi.org/10.1016/j.coche.2013.11.004.

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12

Kostrikov, Serhii, Jens Hjortkjaer, and Torsten Dau. "Vascular Pathology in Age-Related Hearing Loss." Ageing & Longevity, no. 1.2025 (February 20, 2025): 69–72. https://doi.org/10.47855/jal9020-2025-1-9.

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Age-related hearing loss (ARHL) is a growing global healthcare challenge. An increasing body of research suggests an association between ARHL and conditions such as dementia, hypertension, diabetes, and obesity. However, the causal relationships between these pathologies and ARHL remain poorly understood. We propose that vascular pathology may be a key pathogenetic link connecting these conditions, particularly given the inherent vulnerability of the cochlear blood supply and microvasculature. One promising approach for studying vascular pathology in the ageing cochlea involves combining optic

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Xie, Danny F., Christian Crouzet, Krystal LoPresti, et al. "Semi-automated protocol to quantify and characterize fluorescent three-dimensional vascular images." PLOS ONE 19, no. 5 (2024): e0289109. http://dx.doi.org/10.1371/journal.pone.0289109.

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The microvasculature facilitates gas exchange, provides nutrients to cells, and regulates blood flow in response to stimuli. Vascular abnormalities are an indicator of pathology for various conditions, such as compromised vessel integrity in small vessel disease and angiogenesis in tumors. Traditional immunohistochemistry enables the visualization of tissue cross-sections containing exogenously labeled vasculature. Although this approach can be utilized to quantify vascular changes within small fields of view, it is not a practical way to study the vasculature on the scale of whole organs. Thr

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Pommerrenig, Benjamin, Kai Eggert, and Gerd P. Bienert. "Boron Deficiency Effects on Sugar, Ionome, and Phytohormone Profiles of Vascular and Non-Vascular Leaf Tissues of Common Plantain (Plantago major L.)." International Journal of Molecular Sciences 20, no. 16 (2019): 3882. http://dx.doi.org/10.3390/ijms20163882.

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Vascular tissues essentially regulate water, nutrient, photo-assimilate, and phytohormone logistics throughout the plant body. Boron (B) is crucial for the development of the vascular tissue in many dicotyledonous plant taxa and B deficiency particularly affects the integrity of phloem and xylem vessels, and, therefore, functionality of long-distance transport. We hypothesize that changes in the plants’ B nutritional status evoke differential responses of the vasculature and the mesophyll. However, direct analyses of the vasculature in response to B deficiency are lacking, due to the experimen

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Liu, Yanzheng, and Albert Deisseroth. "Tumor vascular targeting therapy with viral vectors." Blood 107, no. 8 (2006): 3027–33. http://dx.doi.org/10.1182/blood-2005-10-4114.

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AbstractTumor angiogenesis is crucial for the progression and metastasis of cancer. The vasculature of tumor tissue is different from normal vasculature. Therefore, tumor vascular targeting therapy could represent an effective therapeutic strategy with which to suppress both primary tumor growth and tumor metastasis. The use of viral vectors for tumor vascular targeting therapy is a promising strategy based on the unique properties of viral vectors. In order to circumvent the potential problems of antiviral neutralizing antibodies, poor access to extravascular tumor tissue, and toxicities to n

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Witkiewicz, Halina, Phil Oh, and Jan E. Schnitzer. "I. Embryonal vasculature formation recapitulated in transgenic mammary tumor spheroids implanted pseudo-orthotopicly into mouse dorsal skin fold: the organoblasts concept." F1000Research 2 (July 11, 2013): 8. http://dx.doi.org/10.12688/f1000research.2-8.v2.

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Inadequate understanding of cancer biology is a problem. This work focused on cellular mechanisms of tumor vascularization. According to earlier studies, the tumor vasculature derives from host endothelial cells (angiogenesis) or their precursors of bone marrow origin circulating in the blood (neo-vasculogenesis) unlike in embryos. In this study, we observed the neo-vasculature form in multiple ways from local precursor cells. Recapitulation of primitive as well as advanced embryonal stages of vasculature formation followed co-implantation of avascular (in vitro cultured) N202 breast tumor sph

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Yogi, Alvaro. "Biochemical and Biomechanical Myogenic Differentiation of Adipose-Derived Stem Cells for Tissue Engineering Applications." Journal of Stem Cells Research, Development & Therapy 7, no. 3 (2021): 1–7. http://dx.doi.org/10.24966/srdt-2060/100079.

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Tissue engineering has shown great promise in generating vascular grafts with properties similar to that of native blood vessels. Vascular Smooth Muscle Cells (VSMC) are the main component of the vasculature tunica media. Recreation of this layer represents a major challenge in tissue engineering due to difficulties in harvesting and culturing autologous VSMC. The use of stem cells and their inherent ability to differentiate into diverse cell types, including vascular lineages, have been proposed

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Born, Gordian, Marina Nikolova, Arnaud Scherberich, Barbara Treutlein, Andrés García-García, and Ivan Martin. "Engineering of fully humanized and vascularized 3D bone marrow niches sustaining undifferentiated human cord blood hematopoietic stem and progenitor cells." Journal of Tissue Engineering 12 (January 2021): 204173142110448. http://dx.doi.org/10.1177/20417314211044855.

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Hematopoietic stem and progenitor cells (HSPCs) are frequently located around the bone marrow (BM) vasculature. These so-called perivascular niches regulate HSC function both in health and disease, but they have been poorly studied in humans due to the scarcity of models integrating complete human vascular structures. Herein, we propose the stromal vascular fraction (SVF) derived from human adipose tissue as a cell source to vascularize 3D osteoblastic BM niches engineered in perfusion bioreactors. We show that SVF cells form self-assembled capillary structures, composed by endothelial and per

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Mirzapour-Shafiyi, Fatemeh, Yukinori Kametani, Takao Hikita, Yosuke Hasegawa, and Masanori Nakayama. "Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis." PLOS Computational Biology 17, no. 6 (2021): e1008398. http://dx.doi.org/10.1371/journal.pcbi.1008398.

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Blood flow governs transport of oxygen and nutrients into tissues. Hypoxic tissues secrete VEGFs to promote angiogenesis during development and in tissue homeostasis. In contrast, tumors enhance pathologic angiogenesis during growth and metastasis, suggesting suppression of tumor angiogenesis could limit tumor growth. In line with these observations, various factors have been identified to control vessel formation in the last decades. However, their impact on the vascular transport properties of oxygen remain elusive. Here, we take a computational approach to examine the effects of vascular br

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Binet, François, Gael Cagnone, Sergio Crespo-Garcia, et al. "Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy." Science 369, no. 6506 (2020): eaay5356. http://dx.doi.org/10.1126/science.aay5356.

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In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening complications, the underlying mechanisms remain unknown. Here, we used orthogonal approaches in human patients with proliferative diabetic retinopathy and a mouse model of ischemic retinopathies to identify an unconventional role for neutrophils in vascular remodeling during late-stage sterile inflammation. Senescent vasculature released a secretome

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Sekine, Ayumi, Tetsu Nishiwaki, Rintaro Nishimura, et al. "Prominin-1/CD133 expression as potential tissue-resident vascular endothelial progenitor cells in the pulmonary circulation." American Journal of Physiology-Lung Cellular and Molecular Physiology 310, no. 11 (2016): L1130—L1142. http://dx.doi.org/10.1152/ajplung.00375.2014.

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Pulmonary vascular endothelial cells could contribute to maintain homeostasis in adult lung vasculature. “Tissue-resident” endothelial progenitor cells (EPCs) play pivotal roles in postnatal vasculogenesis, vascular repair, and tissue regeneration; however, their local pulmonary counterparts remain to be defined. To determine whether prominin-1/CD133 expression can be a marker of tissue-resident vascular EPCs in the pulmonary circulation, we examined the origin and characteristics of prominin-1/CD133-positive (Prom1+) PVECs considering cell cycle status, viability, histological distribution, a

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Hossler, Fred E. "Some quantitative applications of vascular corrosion casting." Proceedings, annual meeting, Electron Microscopy Society of America 50, no. 1 (1992): 738–39. http://dx.doi.org/10.1017/s0424820100124094.

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Preparation of replicas of the complex arrangement of blood vessels in various organs and tissues has been accomplished by infusing low viscosity resins into the vasculature. Subsequent removal of the surrounding tissue by maceration leaves a model of the intricate three-dimensional anatomy of the blood vessels of the tissue not obtainable by any other procedure. When applied with care, the vascular corrosion casting technique can reveal fine details of the microvasculature including endothelial nuclear orientation and distribution (Fig. 1), locations of arteriolar sphincters (Fig. 2), venous

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Sidorenko, A. D., N. A. Omelyanchuk, and E. V. Zemlyanskaya. "Molecular mechanisms of vascular tissue patterning in <i>Arabidopsis thaliana</i> L. roots." Vavilov Journal of Genetics and Breeding 26, no. 8 (2023): 721–32. http://dx.doi.org/10.18699/vjgb-22-88.

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A vascular system in plants is a product of aromorphosis that enabled them to colonize land because it delivers water, mineral and organic compounds to plant organs and provides effective communications between organs and mechanical support. Vascular system development is a common object of fundamental research in plant development biology. In the model plant Arabidopsis thaliana, early stages of vascular tissue formation in the root are a bright example of the self-organization of a bisymmetric (having two planes of symmetry) pattern of hormone distribution, which determines vascular cell fat

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Hägerling, René. "Light sheet microscopy-based 3-dimensional histopathology of the lymphatic vasculature in Emberger syndrome." Phlebologie 49, no. 04 (2020): 242–48. http://dx.doi.org/10.1055/a-1191-8380.

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Abstract Introduction Lymphovascular diseases represent a heterogenous group of inherited and sporadic disorders and refer to a range of possible underlying pathologies and pathogenesis.Emberger Syndrome, an inherited form of lymphedema, is characterized by bilateral lower limb lymphedema, however, upper limbs do not show any signs of swelling.To identify disease-associated histopathological alterations in patients with Emberger Syndrome and to elucidate potential histological differences between the lymphatic vasculature of upper and lower limbs, a detailed knowledge on the 3-dimensional tiss

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Wang, Xinyu, Vincent Chan, and Peter R. Corridon. "Acellular Tissue-Engineered Vascular Grafts from Polymers: Methods, Achievements, Characterization, and Challenges." Polymers 14, no. 22 (2022): 4825. http://dx.doi.org/10.3390/polym14224825.

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Extensive and permanent damage to the vasculature leading to different pathogenesis calls for developing innovative therapeutics, including drugs, medical devices, and cell therapies. Innovative strategies to engineer bioartificial/biomimetic vessels have been extensively exploited as an effective replacement for vessels that have seriously malfunctioned. However, further studies in polymer chemistry, additive manufacturing, and rapid prototyping are required to generate highly engineered vascular segments that can be effectively integrated into the existing vasculature of patients. One recent

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Kim, Jae-Hun, Minji Park, Jin-Hyung Shim, Won-Soo Yun, and Songwan Jin. "Multi-scale vascularization strategy for 3D-bioprinted tissue using coaxial core–shell pre-set extrusion bioprinting and biochemical factors." International Journal of Bioprinting 9, no. 4 (2023): 726. http://dx.doi.org/10.18063/ijb.726.

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Three-dimensional bioprinting is a key technology in bioartificial organ production. However, production of bioartificial organs has significant limitations because it is hard to build vascular structures, especially capillaries, in printed tissue owing to its low resolution. As the vascular structure plays a critical role in delivering oxygen and nutrients to cells and removing metabolic waste, building vascular channels in bioprinted tissue is essential for bioartificial organ production. In this study, we demonstrated an advanced strategy for fabricating multi-scale vascularized tissue usin

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Frey, Carlos, José Luis Acebes, Antonio Encina, and Rafael Álvarez. "Histological Changes Associated with the Graft Union Development in Tomato." Plants 9, no. 11 (2020): 1479. http://dx.doi.org/10.3390/plants9111479.

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Despite the importance of grafting in horticultural crops such as tomato (Solanum lycopersicum L.), the structural changes that occur during the graft establishment are little understood. Using histological techniques, the present work examines the time course of changes on the anatomical structure of the graft junction in functional tomato homografts and compares it to that of heterografts and non-functional grafts. No apparent differences were detected between homo- and heterografts, showing similar tissue development. At 10 days after grafting, the cell walls of the scion and rootstock in t

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Mancio, Jennifer, Evangelos K. Oikonomou, and Charalambos Antoniades. "Perivascular adipose tissue and coronary atherosclerosis." Heart 104, no. 20 (2018): 1654–62. http://dx.doi.org/10.1136/heartjnl-2017-312324.

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Adipose tissue (AT) is no longer viewed as a passive, energy-storing depot, and a growing body of evidence supports the concept that both quantitative and qualitative aspects of AT are critical in determining an individual’s cardiometabolic risk profile. Among all AT sites, perivascular AT (PVAT) has emerged as a depot with a distinctive biological significance in cardiovascular disease given its close anatomical proximity to the vasculature. Recent studies have suggested the presence of complex, bidirectional paracrine and vasocrine signalling pathways between the vascular wall and its PVAT,

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Huang, Xin, Wei-Qun Ding, Joshua L. Vaught, et al. "A soluble tissue factor-annexin V chimeric protein has both procoagulant and anticoagulant properties." Blood 107, no. 3 (2006): 980–86. http://dx.doi.org/10.1182/blood-2005-07-2733.

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AbstractTissue factor (TF) initiates blood coagulation, but its expression in the vascular space requires a finite period of time. We hypothesized that targeting exogenous tissue factor to sites of vascular injury could lead to accelerated hemostasis. Since phosphatidylserine (PS) is exposed on activated cells at sites of vascular injury, we cloned the cDNA for a chimeric protein consisting of the extracellular domain of TF (called soluble TF or sTF) and annexin V, a human PS-binding protein. Both the sTF and annexin V domains had ligand-binding activities consistent with their native counterp

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Salehi, Arjang, Amandine Jullienne, Mohsen Baghchechi та ін. "Up-regulation of Wnt/β-catenin expression is accompanied with vascular repair after traumatic brain injury". Journal of Cerebral Blood Flow & Metabolism 38, № 2 (2017): 274–89. http://dx.doi.org/10.1177/0271678x17744124.

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Recent data suggest that repairing the cerebral vasculature after traumatic brain injury (TBI) may help to improve functional recovery. The Wnt/β-catenin signaling pathway promotes blood vessel formation during vascular development, but its role in vascular repair after TBI remains elusive. In this study, we examined how the cerebral vasculature responds to TBI and the role of Wnt/β-catenin signaling in vascular repair. We induced a moderate controlled cortical impact in adult mice and performed vessel painting to visualize the vascular alterations in the brain. Brain tissue around the injury

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Enbäck, J., and P. Laakkonen. "Tumour-homing peptides: tools for targeting, imaging and destruction." Biochemical Society Transactions 35, no. 4 (2007): 780–83. http://dx.doi.org/10.1042/bst0350780.

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Each normal organ and pathological condition contains organ- or disease-specific molecular tags on its vasculature that constitute a vascular ‘zip code’ system. Tissue-selective tumour metastasis may also depend on vascular addresses. We have used phage display peptide libraries to map disease-specific differences in the vasculature. By using this technology, we have isolated several peptides which are targeted specifically to tumour blood vessels, lymphatic vessels and/or tumour cells. Some of the tumour-homing peptides recognize common angiogenesis markers and are capable of binding to sever

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Perles-Barbacaru, Adriana T., Boudewijn PJ van der Sanden, Regine Farion, and Hana Lahrech. "How Stereological Analysis of Vascular Morphology Can Quantify the Blood Volume Fraction as a Marker for Tumor Vasculature: Comparison with Magnetic Resonance Imaging." Journal of Cerebral Blood Flow & Metabolism 32, no. 3 (2011): 489–501. http://dx.doi.org/10.1038/jcbfm.2011.151.

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To assess angiogenesis noninvasively in a C6 rat brain tumor model, the rapid-steady-state- T1 (RSST1) magnetic resonance imaging (MRI) method was used for microvascular blood volume fraction (BVf) quantification with a novel contrast agent gadolinium per (3,6 anhydro) α-cyclodextrin (Gd-ACX). In brain tissue contralateral to the tumor, equal BVfs were obtained with Gd-ACX and the clinically approved gadoterate meglumine (Gd-DOTA). Contrary to Gd-DOTA, which leaks out of the tumor vasculature, Gd-ACX was shown to remain vascular in the tumor tissue allowing quantification of the tumor BVf. We

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Mace, Maria L., Søren Egstrand, Marya Morevati, Klaus Olgaard, and Ewa Lewin. "New Insights to the Crosstalk between Vascular and Bone Tissue in Chronic Kidney Disease–Mineral and Bone Disorder." Metabolites 11, no. 12 (2021): 849. http://dx.doi.org/10.3390/metabo11120849.

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Vasculature plays a key role in bone development and the maintenance of bone tissue throughout life. The two organ systems are not only linked in normal physiology, but also in pathophysiological conditions. The chronic kidney disease–mineral and bone disorder (CKD-MBD) is still the most serious complication to CKD, resulting in increased morbidity and mortality. Current treatment therapies aimed at the phosphate retention and parathyroid hormone disturbances fail to reduce the high cardiovascular mortality in CKD patients, underlining the importance of other factors in the complex syndrome. T

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Hossler, Fred E. "Vascular Corrosion Casting Can Provide Quantitative as Well as Morphological Information on the Microvasculature of Organs and Tissues." Microscopy Today 6, no. 7 (1998): 14–15. http://dx.doi.org/10.1017/s1551929500068620.

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Complete casts of the vasculature of organs and tissues are obtained by infusing low viscosity resins into the vasculature and allowing the resin to polymerize. Dissolving away the surrounding tissue with alkali leaves a model of the intricate, three-dimensional distribution of vessels in that tissue, which is not easily obtainable by any other means, and which can then be studied with scanning electron microscopy (SEM), Because well prepared casts appear to faithfully replicate the true vascular anatomy of organs including the dimensions of vessels and details of imprints of the endothelial c

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Dean, Ryan J., Simon J. Clarke, Suzy Y. Rogiers, Timothy Stait-Gardner, and William S. Price. "Solute transport within grape berries inferred from the paramagnetic properties of manganese." Functional Plant Biology 44, no. 10 (2017): 969. http://dx.doi.org/10.1071/fp16406.

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Tracer compounds used for studying solute transport should ideally have identical functions and transport properties to the molecules they are designed to mimic. Unfortunately, the xylem-mobile tracer compounds currently used to infer solute transport mechanisms in botanical specimens such as the fruit of the grapevine, Vitis vinifera L., are typically xenobiotic and have difficulty exiting the xylem during berry ripening. Here it is demonstrated that the transport of paramagnetic Mn ions can be indirectly observed within the grape berry, using relaxation magnetic resonance imaging (MRI). Mn i

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Shields, Kelly J., Kostas Verdelis, Michael J. Passineau, et al. "Three-Dimensional Micro Computed Tomography Analysis of the Lung Vasculature and Differential Adipose Proteomics in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension." Pulmonary Circulation 6, no. 4 (2016): 586–96. http://dx.doi.org/10.1086/688931.

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Pulmonary arterial hypertension (PAH) is a rare disease characterized by significant vascular remodeling. The obesity epidemic has produced great interest in the relationship between small visceral adipose tissue depots producing localized inflammatory conditions, which may link metabolism, innate immunity, and vascular remodeling. This study used novel micro computed tomography (microCT) three-dimensional modeling to investigate the degree of remodeling of the lung vasculature and differential proteomics to determine small visceral adipose dysfunction in rats with severe PAH. Sprague-Dawley r

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Shinoka, Toshiharu. "Tissue-Engineered Vascular Grafts in Pediatric Cardiovascular Surgery -Past, Now, and Future." Pediatric Cardiology and Cardiac Surgery 30, no. 5 (2014): 514–22. http://dx.doi.org/10.9794/jspccs.30.514.

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Kugler, Elisabeth, Ryan Snodgrass, George Bowley, et al. "The effect of absent blood flow on the zebrafish cerebral and trunk vasculature." Vascular Biology 3, no. 1 (2021): 1–16. http://dx.doi.org/10.1530/vb-21-0009.

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The role of blood flow in vascular development is complex and context-dependent. In this study, we quantify the effect of the lack of blood flow on embryonic vascular development on two vascular beds, namely the cerebral and trunk vasculature in zebrafish. We perform this by analysing vascular topology, endothelial cell (EC) number, EC distribution, apoptosis, and inflammatory response in animals with normal blood flow or absent blood flow. We find that absent blood flow reduced vascular area and EC number significantly in both examined vascular beds, but the effect is more severe in the cereb

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Rami, Afifah Zahirah Abd, Adila A. Hamid, Nur Najmi Mohamad Anuar, Amilia Aminuddin, and Azizah Ugusman. "Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies." Mediators of Inflammation 2022 (February 8, 2022): 1–16. http://dx.doi.org/10.1155/2022/2734321.

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Initially thought to only provide mechanical support for the underlying blood vessels, perivascular adipose tissue (PVAT) has now emerged as a regulator of vascular function. A healthy PVAT exerts anticontractile and anti-inflammatory actions on the underlying vasculature via the release of adipocytokines such as adiponectin, nitric oxide, and omentin. However, dysfunctional PVAT produces more proinflammatory adipocytokines such as leptin, resistin, interleukin- (IL-) 6, IL-1β, and tumor necrosis factor-alpha, thus inducing an inflammatory response that contributes to the pathogenesis of vascu

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Fuseler, John W., Adam Bedenbaugh, Krishna Yekkala, and Troy A. Baudino. "Fractal and Image Analysis of the Microvasculature in Normal Intestinal Submucosa and Intestinal Polyps in ApcMin/+ Mice." Microscopy and Microanalysis 16, no. 1 (2009): 73–79. http://dx.doi.org/10.1017/s143192760999119x.

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AbstractTumors are supported by the development of a unique vascular bed. We used fractal dimension (Db) and image analysis to quantify differences in the complexity of the vasculature in normal intestinal submucosa and intestinal polyps. ApcMin/+ mice and wild-type mice were perfused with a curable latex compound, intestines sectioned, and images collected via confocal microscopy. The images were analyzed and area (A), perimeter (P), and integrated optical density (IOD) of the normal and tumor vascular beds were measured. The Db, a quantitative descriptor of morphological complexity, was sign

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Lee, Hye-Jin, Haifei Shi, Hella S. Brönneke, et al. "Vascular reactivity contributes to adipose tissue remodeling in obesity." Journal of Endocrinology 251, no. 3 (2021): 195–206. http://dx.doi.org/10.1530/joe-21-0187.

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Vascular reactivity of adipose tissue (AT) is hypothesized to play an important role in the development of obesity. However, the exact role of vascular reactivity in the development of obesity remains unclear. In this study, we investigated the chronological changes in vascular reactivity and the microenvironments of the visceral AT (VAT) and subcutaneous AT (SAT) in lean and obese mice. Changes in blood flow levels induced by a β-adrenoceptor agonist (isoproterenol) were significantly lower in the VAT of the mice fed a high-fat diet (HFD) for 1 and 12 weeks than those in the VAT of the mice f

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Fernández-Alfonso, Maria S., Marta Gil-Ortega, Concha F. García-Prieto, Isabel Aranguez, Mariano Ruiz-Gayo, and Beatriz Somoza. "Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity." International Journal of Endocrinology 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/402053.

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Most blood vessels are surrounded by adipose tissue. Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies. In 1991, Soltis and Cassis demonstrated for the first time that PVAT reduced contractions to noradrenaline in rat aorta. Since then, an important number of adipocyte-derived factors with physiological and pathophysiological paracrine vasoactive effects have been identified. PVAT undergoes structural and functional changes in obesity. During ear

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Chang, Lin, Minerva T. Garcia-Barrio, and Y. Eugene Chen. "Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells." Arteriosclerosis, Thrombosis, and Vascular Biology 40, no. 5 (2020): 1094–109. http://dx.doi.org/10.1161/atvbaha.120.312464.

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Adipose tissues are present at multiple locations in the body. Most blood vessels are surrounded with adipose tissue which is referred to as perivascular adipose tissue (PVAT). Similarly to adipose tissues at other locations, PVAT harbors many types of cells which produce and secrete adipokines and other undetermined factors which locally modulate PVAT metabolism and vascular function. Uncoupling protein-1, which is considered as a brown fat marker, is also expressed in PVAT of rodents and humans. Thus, compared with other adipose tissues in the visceral area, PVAT displays brown-like characte

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Maina, Renee M., Maria J. Barahona, Michele Finotti, et al. "Generating vascular conduits: from tissue engineering to three-dimensional bioprinting." Innovative Surgical Sciences 3, no. 3 (2018): 203–13. http://dx.doi.org/10.1515/iss-2018-0016.

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AbstractVascular disease – including coronary artery disease, carotid artery disease, and peripheral vascular disease – is a leading cause of morbidity and mortality worldwide. The standard of care for restoring patency or bypassing occluded vessels involves using autologous grafts, typically the saphenous veins or internal mammary arteries. Yet, many patients who need life- or limb-saving procedures have poor outcomes, and a third of patients who need vascular intervention have multivessel disease and therefore lack appropriate vasculature to harvest autologous grafts from. Given the steady i

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Li, Jian-Jun, Yao-Qi Huang, Ross Basch, and Simon Karpatkin. "Thrombin Induces the Release of Angiopoietin-1 from Platelets." Thrombosis and Haemostasis 85, no. 02 (2001): 204–6. http://dx.doi.org/10.1055/s-0037-1615677.

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SummaryBlood platelets contain angiopoietin-1, a growth factor essential for blood vessel development via stabilization of proliferating endothelial cells. It has recently been reported that angiopoietin-1 can act as a vascular stability factor (Nature Medicine 6:460, 2000). In investigating the normal tissue distribution of angiopoietin-1 from surgically-removed frozen specimens by RT-PCR, we found it consistently present in platelets and megakaryocytes, usually absent in relatively non-vascular tissue: breast, colon, lung, skin, kidney, thyroid, testicle, cervix and occasionally present in t

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Lengyel, Balazs C., Ponraj Chinnadurai, Rebecca G. Barnes, Charudatta S. Bavare, and Alan B. Lumsden. "Early Concepts in CT Image-Guided Robotic Vascular Surgery: The Displacement of Retroperitoneal Structures During Simulated Procedures in a Cadaveric Model." Tomography 11, no. 6 (2025): 60. https://doi.org/10.3390/tomography11060060.

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Background: CT image guidance and navigation, although routinely used in complex endovascular procedures, is an unexplored territory in evolving vascular robotic procedures. In robotic surgery, it promises the better localization of vasculature, the optimization of port placement, less inadvertent tissue damage, and increased patient safety during the dissection of retroperitoneal structures. However, unknown tissue displacement resulting from induced pneumoperitoneum and positional changes compared to the preoperative CT scan can pose significant limitations to the reliability of image guidan

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Woolf, Zoe, Susan Li, Molly Swanson, et al. "TMIC-23. UNRAVELLING THE HETEROGENEITY OF GLIOBLASTOMA'S VASCULAR LANDSCAPE." Neuro-Oncology 25, Supplement_5 (2023): v283. http://dx.doi.org/10.1093/neuonc/noad179.1089.

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Abstract BACKGROUND Glioblastoma tumours are highly vascular and angiogenic. However, they are also heterogeneous, comprising many different macro- and microenvironments. Reflecting this, tumour-associated blood vessels are variable in their distribution, structure, and function. Despite the significance of vasculature in the development and progression of glioblastoma, its complexity remains poorly defined. Therefore, characterising vascular diversity across the glioblastoma landscape is a crucial step in the development of targeted therapies. METHODS 40 glioblastoma and 5 epilepsy cases were

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Banerjee, Indroneal, John W. Fuseler, Colby A. Souders, Stephanie L. K. Bowers, and Troy A. Baudino. "The Role of Interleukin-6 in the Formation of the Coronary Vasculature." Microscopy and Microanalysis 15, no. 5 (2009): 415–21. http://dx.doi.org/10.1017/s1431927609990353.

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AbstractThe formation and the patterning of the coronary vasculature are critical to the development and pathology of the heart. Alterations in cytokine signaling and biomechanical load can alter the vascular distribution of the vessels within the heart. Changes in the physical patterning of the vasculature can have significant impacts on the relationships of the pressure-flow network and distribution of critical growth and survival factors to the tissue. Interleukin-6 (IL-6) is a pleiotropic cytokine that regulates several biological processes, including vasculogenesis. Using both immunohisto

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Mignemi, Nicholas, Heather Cole, Masato Yausa, David Gailani, Jay L. Degen, and Jonathan G. Schoenecker. "Deficiency in Plasminogen Cause Decreased Vascularity in Sold Tissue Organs and Bone." Blood 118, no. 21 (2011): 857. http://dx.doi.org/10.1182/blood.v118.21.857.857.

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Abstract Abstract 857 A sufficient vascular supply is critical for proper physiologic function of solid-tissue organs and bone. Tissue vascularity is mediated concomitantly through vascular patency and angiogenesis. Recently, numerous studies have associated plasminogen, the key fibrinolytic protease of the coagulation system, with maintaining vascular patency by preventing fibrin accumulation with in the vasculature. Additionally, plasminogen may also have a direct role in angiogenesis as it has been shown in vitro that inhibitors of plasmin(ogen) suppress formation of capillary structures fr

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Hoffmann, Nathan E., and John C. Bischof. "Cryosurgery of Normal and Tumor Tissue in the Dorsal Skin Flap Chamber: Part II—Injury Response." Journal of Biomechanical Engineering 123, no. 4 (2001): 310–16. http://dx.doi.org/10.1115/1.1385839.

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It has been hypothesized that vascular injury may be an important mechanism of cryosurgical destruction in addition to direct cellular destruction. In this study, we report correlation of tissue and vascular injury after cryosurgery to the temperature history during cryosurgery in an in vivo microvascular preparation. The dorsal skin flap chamber, implanted in the Copenhagen rat, was chosen as the cryosurgical model. Cryosurgery was performed in the chamber on either normal skin or tumor tissue propagated from an AT-1 Dunning rat prostate tumor, as described in a companion paper (Hoffmann and

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