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Relevant bibliographies by topics / Tissue design / Dissertations / Theses

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Dissertations / Theses on the topic 'Tissue design'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Hoang, Tuyen. "Experimental design considerations for tissue microarrays." Diss., Restricted to subscribing institutions, 2004. http://proquest.umi.com/pqdweb?did=795970721&sid=14&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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2

Entezari, Ali. "Characterization and Design of Bone Tissue Scaffolds." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20008.

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Biological and mechanical functions are sometimes two conflicting characteristics of bone tissue scaffolds, thus a trade-off between these two properties is critical. An ideal scaffold not only should be strong but also must possess adequate permeability to allow efficient transport of oxygen and nutrients. Mechanical stimulation is another important parameter known to control bone tissue formation in the scaffolds. Therefore, effective tools capable of reliably characterising and optimising different material properties of bone scaffolds are necessary in order to enhance bone regeneration out

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3

Starly, Binil Sun Wei. "Biomimetic design and fabrication of tissue engineered scaffolds using computer aided tissue engineering /." Philadelphia, Pa. : Drexel University, 2006. http://hdl.handle.net/1860/1114.

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4

Chin, Quee Shawn L. "Design verification for tissue engineered vascular grafts." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/19689.

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5

Chang, Che-Cheng Bryant. "Design and Topology Optimisation of Tissue Scaffolds." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14161.

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Tissue restoration by tissue scaffolding is an emerging technique with many potential applications. While it is well-known that the structural properties of tissue scaffolds play a critical role in cell regrowth, it is usually unclear how optimal tissue regeneration can be achieved. This thesis hereby presents a computational investigation of tissue scaffold design and optimisation. This study proposes an isosurface-based characterisation and optimisation technique for the design of microscopic architecture, and a porosity-based approach for the design of macroscopic structure. The goal of thi

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6

Lapera, Malcolm Gerald. "Design of Controlled Environment for Tissue Engineering." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1155.

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Design of Controlled Environment for Tissue Engineering Malcolm Lapera Tissue engineering aims at relieving the need for donor tissue and organs by developing a process of creating viable tissues in the laboratory setting. With over 120,000 people awaiting a transplant, the need for generating tissue engineered organs is very large [3]. In order for organs to be engineered, a few issues need to be overcome. A work space that both creates an environment which maintains cell viability over an extended period of time as well as accommodates the necessary fabrication equipment will be needed to fu

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7

Wen, Demin. "Cortical Bone Engineering: Scaffold Design And Cell Selection." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1257965626.

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8

Sachot, Nadège. "Design of hybrid fibers for bone tissue engineering." Doctoral thesis, Universitat Politècnica de Catalunya, 2014. http://hdl.handle.net/10803/285335.

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Most of the conventional organic-inorganic composite materials developed for bone tissue engineering do not possess intimate interactions between their constituents. As a consequence, they generally degrade in a non-homogeneous manner and lose easily their integrity under mechanical load. On the other hand, their bioactive phase (i.e. inorganic) is often masked by the polymeric one, resulting in a non optimal bioactivity. To overcome these problems, hybrid materials can be produced. Hybrids are composites that exhibit an improved synergy between their compounds at the nanoscale. Using the sol-

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9

Halili, Ndreu Albana. "Collagen-based Meniscus Tissue Engineering: Design And Application." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613451/index.pdf.

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Meniscus is a wedge shaped structure, with a convex base attached to a flat tibial surface, and with a concave femoral surface, on which femur and tibia articulate. It has several functions including joint lubrication, shock absorption, load transmission and joint stability. Various methods were tried to treat meniscal tears but each has its own drawbacks. Tissue engineering seems to be a promising solution that avoids all the problems associated with the other approaches. In this study, a three dimensional (3D) collagen-based structure was prepared by tissue engineering to mimic the natural h

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10

Deplaine, Harmony. "Scaffold design and characterisation for osteochondral tissue regeneration." Doctoral thesis, Universitat Politècnica de València, 2012. http://hdl.handle.net/10251/14638.

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El objetivo principal de esta tesis doctoral es el diseño de un andamio polimérico bicapa macroporoso para la regeneración del complejo osteocondral. El material empleado para la fabricación del constructo ha sido el ácido poli(L-láctico), un polímero biodegradable de la familia de los poliésteres. Una de las capas del andamio ha sido diseñada para asistir la regeneración del cartílago articular. La otra capa sirve de anclaje al hueso subcondral, y se diferencia de la anterior en sus propiedades mecánicas y bioactividad. Este comportamiento ha sido logrado por combinación del ácido poli(L-láct

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11

Tocchio, A. "DESIGN OF VASCULARIZABLE SCAFFOLDS FOR LARGE TISSUE ENGINEERING." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/234142.

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The emerging field of tissue engineering is dedicated to restore, maintain or improve the functions of damaged or lost human tissues. However, despite significant successes have been achieved over the last 20 years, several challenges still remain, preventing a pervasive clinical application of tissue engineering. One of the main challenges lies in the development of scaffolding materials able to mimic the complex organization of the in vivo milieu and provide tailored stimuli for tissue growth and maturation. A fundamental aspect of this problem resides in the design of scaffolds having three

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12

Darling, Andrew Leete. "Functional design and fabrication of heterogeneous tissue engineering scaffolds /." Philadelphia, Pa. : Drexel University, 2005. http://dspace.library.drexel.edu/handle/1860/662.

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13

Smuts, Adriaan Nicolaas. "Design of tissue leaflets for a percutaneous aortic valve." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1625.

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MScEng<br>Thesis (MScEng (Mechanical and Mechatronic Engineering))--University of Stellenbosch, 2009.<br>In this project the shape and attachment method of tissue leaflets for a percutaneous aortic valve is designed and tested as a first prototype. Bovine and kangaroo pericardium was tested and compared with natural human valve tissue by using the Fung elastic constitutive model for skin. Biaxial tests were conducted to determine the material parameters for each material. The constitutive model was implemented using finite element analysis (FEA) by applying a user-specified subroutine. The FEA

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14

PATRUCCO, ALESSIA. "KERATIN-BASED 3D SCAFFOLD DESIGN FOR BONE TISSUE ENGINEERING." Doctoral thesis, Università degli studi di Pavia, 2017. http://hdl.handle.net/11571/1203394.

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In questo lavoro di tesi è stato progettato e caratterizzato uno scaffold 3D di cheratina innovativo tramite un approccio bio-ingegneristico integrato che unisce anche lo stimolo bio-meccanico generato da un campo elettromagnetico pulsato (PEMF). Lo scaffold è stato preparato mediante la fibrillazione di fibre di lana (cheratina) sfruttando i componenti istologici che le compongono (fibrille o cellule corticali), al fine di ottenere una struttura adatta alla rigenerazione ossea. E’ stato quindi progettato uno scaffold di cheratina (spugna di fibrille di lana) con micro e macro-porosità interco

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15

Enrico, Merzari. "Bioreactor Design for Dynamic Process Optimization in Tissue Engineering." Doctoral thesis, Università degli studi di Trento, 2011. https://hdl.handle.net/11572/368295.

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Tissue engineering is an interdisciplinary field in which cell biology, biomaterials science, and surgery are combined and its main goal is to repair, replace and reproduce tissues and organs. Following this procedure, cells are seeded on proper scaffolds and induced in sequence to adhere, eventually differentiate, proliferate and finally to produce the wanted extracellular matrix (ECM). During cell culture, the usefulness of applying proper physiological-like stimuli, i.e., biochemical but also mechanical signals to drive and accelerate both cell differentiation and ECM production has been de

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16

Enrico, Merzari. "Bioreactor Design for Dynamic Process Optimization in Tissue Engineering." Doctoral thesis, University of Trento, 2011. http://eprints-phd.biblio.unitn.it/548/1/Bioreactor_Design_for_Dynamic_Process_Optimization_in_Tissue_engineering.pdf.

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Tissue engineering is an interdisciplinary field in which cell biology, biomaterials science, and surgery are combined and its main goal is to repair, replace and reproduce tissues and organs. Following this procedure, cells are seeded on proper scaffolds and induced in sequence to adhere, eventually differentiate, proliferate and finally to produce the wanted extracellular matrix (ECM). During cell culture, the usefulness of applying proper physiological-like stimuli, i.e., biochemical but also mechanical signals to drive and accelerate both cell differentiation and ECM production has been d

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17

Williams, Chrysanthi. "Perfusion bioreactor for tissue-engineered blood vessels." Diss., Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-06072004-131410/unrestricted/williams%5Fchrysantyhi%5F200405%5Fphd.pdf.

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18

Blogg, Ken. "The selection and application of design methodologies for the design of bone tissue scaffolds." Thesis, Cranfield University, 2013. http://dspace.lib.cranfield.ac.uk/handle/1826/8604.

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Research motivation: Bone tissue scaffolds offer a way forward in a strategy to change from tissue replacement to tissue regeneration. Bone tissue scaffolds are a combination of a physical construct, with clearly defined three-dimensional spatial properties, and biological cells. The microstructure of this construct is the bridge between the physicochemical properties of the scaffold and the cellular processes responsible for tissue regeneration. Gap statement: A formal design methodology has yet to be applied for the design of bone tissue scaffolds Aims and objectives: The aim of this researc

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19

Howes, Stuart C. "Design of a noninvasive system for the evaluation of collagen scaffolds using MRI." Link to electronic thesis, 2007. http://www.wpi.edu/Pubs/ETD/Available/etd-052507-131736/.

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20

Moore, Timothy Graeme, and tim moore@csiro au. "Design and synthesis of biodegradable thermoplastic polyurethanes for tissue engineering." Swinburne University of Technology, 2005. http://adt.lib.swin.edu.au./public/adt-VSWT20060223.121928.

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The aim of this study was to design and synthesise thermoplastic biodegradable and biocompatible polyurethanes for tissue engineering applications. A secondary aim was to tailor a range of degradation rates of the polyurethanes to suit a broad spectrum of tissue engineering applications. Various factors were systematically investigated in order to provide a means of controlling mechanical, thermal and degradation properties of the polyurethanes. The factors investigated included variation of the hard segment percentage, the diisocyanate, the soft segment macrodiol as well as the chain extender

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21

Moroni, Lorenzo. "A mechanistic approach to design smart scaffolds for tissue engineering." Enschede : University of Twente [Host], 2006. http://doc.utwente.nl/57610.

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22

Ye, Jin Cheng. "Design and Assembly Considerations in the Engineering of Vascular Tissue." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11291.

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Native vascular tissue functions are highly dependent on structural organization at the super-cellular, cellular, and sub-cellular spatial scales. We hypothesized that the structure-function relationship of vascular tissues in vivo can be leveraged to engineer vascular tissues in vitro by prescribing the shape of constituent cells and their assembly into organized three-dimensional structures. To this end, we first asked if vascular smooth muscle cell shape influences cellular contractility. We engineered human vascular smooth muscle cells to assume similar shapes to those in elastic and muscu

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23

Uth, Nicholas P. "Computational Design and Optimization of Bone Tissue Engineering Scaffold Topology." Miami University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1452783077.

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24

Jaklenec, Ana. "Design and modulation of growth factor delivery systems for tissue engineering." View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318332.

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25

Mukherjee, Indra Neil. "A rational design approach for the cryopreservation of natural and engineered tissues." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/22579.

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Thesis (Ph. D.)--Chemical and Biomolecular Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Sambanis, Athanassios; Committee Member: Long, Jr., Robert C.; Committee Member: Ludovice, Peter J.; Committee Member: Prausnitz, Mark R.; Committee Member: Song, Ying C.

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26

Chhaya, Mohit Prashant. "Additive tissue manufacturing for breast reconstruction: Combining CAD/CAM with adipose tissue engineering." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/84762/9/Mohit_Prashant_Chhaya_Thesis.pdf.

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The primary aim of this multidisciplinary project was to develop a new generation of breast implants. Disrupting the currently prevailing paradigm of silicone implants which permanently introduce a foreign body into mastectomy patients, highly porous implants developed as part of this PhD project are biodegradable by the body and augment the growth of natural tissue. Our technology platform leverages computer-assisted-design which allows us to manufacture fully patient-specific implants based on a personalised medicine approach. Multiple animal studies conducted in this project have shown that

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27

Liu, Janet. "Design of a Novel Tissue Culture System to Subject Aortic Tissue to Multidirectional Bicuspid Aortic Valve Wall Shear Stress." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1527077368757049.

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28

Tsui, Yuen-kee, and 崔婉琪. "New biodegradable polyhydroxyacids and polyurethane scaffolds for tissue engineering." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B30595757.

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29

Stuhlen, Birgit. "The mechanical design of turgid plant tissues." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312582.

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30

Kutay, Karabag. "A Computational Architecture Methodology For Design In Traditional Tissue: The Case Of Kalkan." Phd thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612656/index.pdf.

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This study targets to address the problem of &#039<br>new building in a traditional setting&#039<br>, utilizing computational design tools. The intention is to provide a methodology for analysis of architectural features of a traditional tissue and moreover propose computational design strategies utilizing algorithms for processing analytical data serving new building design. In the introduction part, this goal is exposed as well as a critic discussion based on a conservationist perspective for contemporary examples of computational design. Contemporary digital tools and methods employed in th

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31

Curto, Marco. "Design methods and geometric modelling of scaffolds for bone tissue engineering." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7989/.

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Every year, thousand of surgical treatments are performed in order to fix up or completely substitute, where possible, organs or tissues affected by degenerative diseases. Patients with these kind of illnesses stay long times waiting for a donor that could replace, in a short time, the damaged organ or the tissue. The lack of biological alternates, related to conventional surgical treatments as autografts, allografts, e xenografts, led the researchers belonging to different areas to collaborate to find out innovative solutions. This research brought to a new discipline able to merge molecula

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32

Crofts, Clare Elizabeth. "Pericardial heterografts : tissue mechanical properties and their implications for valve design." Thesis, University of Sheffield, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285530.

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33

Brickman, Raredon Micha Sam. "Design and fabrication of physiologic tissue scaffolds using projection-micro-stereolithography." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90086.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2014.<br>35<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 65-67).<br>Recent advances in material processing are presenting groundbreaking opportunities for biomedical engineers. Projection-micro-stereolithography, or PuSL, is an additive manufacturing technique in which complex parts are built out of UV-curable resins using ultraviolet light. The primary strength of PuSL is its capacity to translate CAD files into three-dimensional parts with unusually

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34

Almeida, Henrique de Amorim. "Smart design of scaffolds obtained by biofabrication for tissue engineering applications." Doctoral thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/11351.

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Doutoramento em Engenharia Mecânica<br>A engenharia de tecidos é um domínio tecnológico emergente em rápido desenvolvimento que se destina a produzir substitutos viáveis para a restauração, manutenção ou melhoria da função dos tecidos ou órgãos humanos. Uma das estratégias mais predominantes em engenharia de tecidos envolve crescimento celular sobre matrizes de suporte (scaffolds), biocompatíveis e biodegradáveis. Estas matrizes devem possuir não só elevadas propriedades mecânicas e vasculares, mas também uma elevada porosidade. Devido à incompatibilidade destes dois parâmetros, é nece

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35

Bramhill, Jane. "Design and synthesis of proteoglycan analogues for tissue repair and regeneration." Thesis, Aston University, 2012. http://publications.aston.ac.uk/16436/.

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This thesis is concerned with the design and synthesis of a novel, injectable proteoglycan analogue for tissue repair. This is of particular relevance to the restoration of disc height to a degraded nucleus pulposus of the intervertebral disc. The focus is on the use of sulfonate monomers as proteoglycan analogues, in particular sodium 2-acrylamido-2-methylpropane sulfonic acid and the potassium salt of 3-sulfopropyl acrylate. For most biomedical applications, synthetic hydrogels need to show dimensional stability to changes in pH, osmolarity, and temperature. This is readily achieved by neutr

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36

IVIGLIA, GIORGIO. "DESIGN, DEVELOPMENT AND CHARACTERIZATION OF NOVEL BIOMATERIALS FOR PERIODONTAL TISSUE ENGINEERING." Doctoral thesis, Politecnico di Torino, 2016. http://hdl.handle.net/11583/2643569.

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Periodontium is a complex system of different tissues, such as connective tissue, cartilage and bone, which work together to sustain the tooth. Gingivitis and periodontitis are devastating diseases that could affect the structure and function of the periodontal tissue. When the gingivitis are not treated and controlled with a correct oral hygiene, they could evolve in periodontitis, which could seriously damage the tissue surrounding the tooth and lead tooth loss. The main objective of periodontal tissue engineering is to regenerate the tooth’s supporting tissues. Periodontal tissue regenerati

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37

Kumar, Vivek Ashok. "Design and evaluation of scaffolds for arterial grafts using extracellular matrix based materials." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45869.

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For small diameter (<6 mm) blood vessel replacements, lack of collaterals and vascular disease preclude homografts; while synthetic analogs, ePTFE, expanded polytetrafluoroethylene, and PET, polyethyleneterephathalate, are prone to acute thrombosis and restenosis. It is postulated that the hierarchical assembly of cell populated matrices fabricated from protein analogs provides a new design strategy for generating a structurally viable tissue engineered vascular graft. To this end, synthetic elastin and collagen fiber analogs offer a novel strategy for creating tissue engineered vascular graft

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38

Grieve, Andrew Paul. "Soft tissue mechanical properties and the design of pressure distributing seat cushions." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306036.

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39

RUSSO, LAURA. "design of smart biomaterials." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/28929.

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The general aim of the project is the development of innovative materials for bone and cartilage tissue engineering, focusing on the design of smart biomimetic materials, fully integrating principles from cell and molecular biology able to directly regulate cell differentiation and metabolism. Materials equipped with molecular cues mimicking the structure or function of natural extracellular microenvironments are able to interact with surrounding tissues by biomolecular recognition (Lutolf, MP 2005). Biomimetic materials should be capable of eliciting specific cellular responses and directing

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40

Liu, Fengyuan. "Design, fabrication and evaluation of a hybrid biomanufacturing system for tissue engineering." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/design-fabrication-and-evaluation-of-a-hybrid-biomanufacturing-system-for-tissue-engineering(13717125-61ac-4f95-a83b-62a706a5ea15).html.

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The combined use of additive manufacturing (AM), biocompatible and biodegradable materials, cells and biomolecular signals is the most common biomanufacturing strategy applied in scaffold fabrication. AM processes offer a better control and the ability to actively design the porosity and interconnectivity of the scaffolds. When combined with clinical imaging data, these fabrication techniques can be used to produce constructs that are customised to the shape of the defect or injury. However, due to the hydrophobicity of the commonly used synthetic biopolymers, cell-seeding and proliferation ef

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41

Wingkono, Gracy A. "Design and characterization of materials." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31735.

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42

Taplin, Temeka. "Design and construction of a compact multi-chamber tissue equivalent proportional counter." Texas A&M University, 2005. http://hdl.handle.net/1969.1/3221.

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This project was designed to determine the feasibility of constructing a multichamber proportional counter. A multi-chamber detector is designed to increase the total surface area which will increase the number of radiation interactions that occur per unit dose. Surface area can be changed without changing the detector volume by subdividing the active volume into several smaller volumes that can then be used as mini detectors whose data can be summed and used to determine the absorbed dose. This will allow the total surface area to remain the same as that of the more common 12.5 cm (5 in.) sph

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43

Porter, Emily. "Microwave breast tumor detection: simulation and design of experiments with tissue phantoms." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95123.

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Recently, microwave imaging has been proposed as a technique for early detection of breast cancer. It is based on the intrinsic contrast in the dielectric properties of healthy and cancerous breast tissues at microwave frequencies. An ultrawideband pulse is transmitted through the breast and a portion of it is scattered when interfaces between two tissues (i.e., fat and tumor) are encountered. The scattered signal is received by antennas surrounding the breast and analyzed to reveal tumor size and location. This work presents a proposed system for time-domain microwave breast imaging. The

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44

Sutherland, Fraser William Havern. "Design of a tissue engineered semilunar heart valve for the pulmonary position." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612703.

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45

Anowarul, Islam. "BIOMIMETIC SCAFFOLD DESIGN FOR TENDON TISSUE ENGINEERING TO ENHANCE MECHANORESPONSE AND TENOGENESIS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1473424226657921.

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46

Tanahashi, Kazuhiro. "DESIGN AND PREPARATION OF FUMARATE-BASED BIODEGRADABLE POLYMER HYDROGELS FOR TISSUE ENGINEERING." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124562.

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47

Tighe, Jonathan L'Estrange. "Industrial design in endoscopy : the development of a tissue and organ extractor." Thesis, Queensland University of Technology, 1997. https://eprints.qut.edu.au/36028/7/36028_Digitised_Thesis.pdf.

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Throughout history, developments in medicine have aimed to improve patient quality of life, and reduce the trauma associated with surgical treatment. Surgical access to internal organs and bodily structures has been traditionally via large incisions. Endoscopic surgery presents a technique for surgical access via small (1 Omm) incisions by utilising a scope and camera for visualisation of the operative site. Endoscopy presents enormous benefits for patients in terms of lower post operative discomfort, and reduced recovery and hospitalisation time. Since the first gall bladder extractio

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48

Shabab, Tara. "Design, advanced manufacturing and characterization of multiphasic scaffolds for tissue engineering applications." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/210851/1/Tara_Shabab_Thesis.pdf.

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This study takes advantage of combining two tissue engineering scaffold fabrication techniques, namely melt extrusion-based 3D printing and porogen leaching, to develop multiscale scaffolds, consisting of an interconnected network, in order to address the requirements of the tissue regeneration process. The scaffolds were characterised and the effect of the microporous surface on cell response and microporous structure on drug release were investigated. The results of this study show microporosity and macroporosity can be modified to optimize scaffold properties based on the requirements of a

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49

Stoppato, Matteo. "Bone Tissue Engineering: structures and strategies for functional scaffold design and evaluation." Doctoral thesis, Università degli studi di Trento, 2013. https://hdl.handle.net/11572/369258.

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Skeletal tissue has a good ability to self-regenerate after injury through the processes of bone healing. However, bone can suffer from a wide range of pathologies, cancers or congenital defects which lead to loss of bone mass and density. Current progresses in tissue engineering have shown great potential for creating biological alternatives and new perspectives for the treatment of bone damage and defects. In this approach, scaffolding plays a pivotal role. In particular, the principles of biomimesis have to be followed and the scaffolds have to be designed to this purpose. Furthermore, thes

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50

Stoppato, Matteo. "Bone Tissue Engineering: structures and strategies for functional scaffold design and evaluation." Doctoral thesis, University of Trento, 2013. http://eprints-phd.biblio.unitn.it/983/1/Thesis-nochapter3-withcopyright.pdf.

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Skeletal tissue has a good ability to self-regenerate after injury through the processes of bone healing. However, bone can suffer from a wide range of pathologies, cancers or congenital defects which lead to loss of bone mass and density. Current progresses in tissue engineering have shown great potential for creating biological alternatives and new perspectives for the treatment of bone damage and defects. In this approach, scaffolding plays a pivotal role. In particular, the principles of biomimesis have to be followed and the scaffolds have to be designed to this purpose. Furthermore, the

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