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Dissertations / Theses on the topic 'Tissue engineering. Articular cartilage'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

Getgood, Alan Martin John. "Articular cartilage tissue engineering." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608764.

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2

Pérez, Olmedilla Marcos. "Tissue engineering techniques to regenerate articular cartilage using polymeric scaffolds." Doctoral thesis, Universitat Politècnica de València, 2015. http://hdl.handle.net/10251/58987.

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[EN] Articular cartilage is a tissue that consists of chondrocytes surrounded by a dense extracellular matrix (ECM). The ECM is mainly composed of type II collagen and proteoglycans. The main function of articular cartilage is to provide a lubricated surface for articulation. Articular cartilage damage is common and may lead to osteoarthritis. Articular cartilage does not have blood vessels, nerves or lymphatic vessels and therefore has limited capacity for intrinsic healing and repair. Tissue engineering (TE) is a powerful approach for healing degenerated cartilage. TE uses three-dimensiona

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3

Senior, Richard. "Optimising culture conditions for tissue engineering large articular cartilage constructs." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7716/.

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Current surgical approaches to treating damage to articular cartilage, a highly specialised connective tissue, are limited in their ability to regenerate functional hyaline tissue. This has provided a driving force for the development of patient-specific, tissue engineered treatments. To date the majority of in vitro studies have focussed on engineering relatively small-dimension constructs; however justification remains for the production of large pieces of cartilage tissue. The aim of this research was therefore to investigate the potential for tissue engineering large, high quality cartilag

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4

Bliss, Cody Larry. "Sensate Scaffolds for Articular Cartilage Repair." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194815.

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Polymer scaffold use has become commonplace in tissue engineering strategies. Scaffolds provide sturdy interfaces that securely anchor tissue engineered constructs to their designated locations. Researchers have used scaffolds to provide support to developing tissues as well as a growth template to aid the development of the desired phenotypic structure. In addition to using scaffolds for their mechanical support, scaffolds can be used as a diagnostic tool by attaching sensors. Strain gauge sensors have been attached to scaffolds to monitor compression and elongation. These polybutylterpha

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5

Vickers, Scott M. (Scott Mitchell) 1978. "Cell-seeded type II collagen scaffolds for articular cartilage tissue engineering." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/38926.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.<br>Includes bibliographical references (p. 149-164).<br>Defects in articular cartilage exhibit little spontaneous healing response, in part due to the limited number of chondrocytes available to infiltrate the defect and the absence of a provisional fibrin scaffold to accommodate cell migration into the lesion. One variable related to tissue engineering strategies employing cell-seeded scaffolds to treat such defects is the amount of cartilage formed in the construct prior to implantation. The object

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6

Mahajan, Harshal Prabhakar. "Evaluation of chitosan gelatin complex scaffolds for articular cartilage tissue engineering." Master's thesis, Mississippi State : Mississippi State University, 2005. http://sun.library.msstate.edu/ETD-db/ETD-browse/browse.

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7

Akmal, Mohammed. "The use of dynamic culture devices in articular cartilage tissue engineering." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444064/.

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Tissue engineered repair of articular cartilage has now become a clinical reality with techniques for cell culture having advanced from laboratory experimentation to clinical application. Despite the advances in the use of this technology in clinical applications, the basic cell culture techniques for autologous chondrocytes are still based on primitive in-vitro monolayer culture methods. Articular chondrocytes are known to undergo fibroblastic change in monolayer culture as this is not their normal state in-vivo. They are more likely to maintain their phenotype when cultured in three dimensio

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8

Boyer, Sam. "Characterisation of articular cartilage progenitor cells : potential use in tissue engineering." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/56057/.

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Articular cartilage is a resilient and load bearing material that provides diarthrodial joints with excellent friction, lubrication and wear characteristics required for continuous motion. However, articular cartilage has a poor regenerative capacity and its degeneration is a common cause of morbidity in terms of loss of joint function and osteoarthritis, frequently resulting in the need for total knee replacement. Articular cartilage has a distinct zonal architecture with biochemical and cellular variations existing from the surface zone to the deeper calcified layers. Thus, the development o

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9

Steele, Joseph Allan McKinnon. "Development of scaffolds incorporating zonal complexity for articular cartilage tissue engineering." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/52781.

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Articular cartilage is an anisotropic tissue composed of compositional and functional layers. One clinical approach to the regeneration of articular cartilage defects incorporates a porous polymer scaffold to support and direct cartilage formation in full‐thickness defects. These scaffolds are regularly isotropic in structure, unlike the tissue they aim to regenerate. A number of scaffold production techniques were combined to produce porous anisotropic scaffolds with zonally‐biomimetic microarchitecture and mechanical properties. The final scaffold design featured a combination of an electros

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10

Nam, Jin. "Electrospun polycaprolactone scaffolds under strain and their application in cartilage tissue engineering." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1157828634.

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11

Choudhry, Sadaf. "The characterisation of articular chondrocyte seeded chitosan hydrogels for cartilage tissue engineering." Thesis, Queen Mary, University of London, 2009. http://qmro.qmul.ac.uk/xmlui/handle/123456789/448.

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Cartilage is a type of connective tissue which has very little potential for spontaneous natural repair when damaged. The use of tissue engineering for the treatment of articular cartilage has been investigated for a number of years. However, due to its unique biomechanical properties and functional requirements, the neo-tissues produced thus far have proved to be of limited long-term functionality. One avenue being investigated is the use of cell-seeded scaffolds as cartilage templates. Chitosan is a natural, abundant polysaccharide, biocompatible and biodegradable, with the ability to form o

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12

Yu, Yin. "Articular cartilage tissue engineering using chondrogenic progenitor cell homing and 3D bioprinting." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/6895.

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Articular cartilage damage associated with joint trauma seldom heals and often leads to osteoarthritis (OA). Current treatment often fails to regenerated functional cartilage close to native tissue. We previously identified a migratory chondrogenic progenitor cell (CPC) population that responded chemotactically to cell death and rapidly repopulated the injured cartilage matrix, which suggested their potential for cartilage repair. To test that potential we filled experimental full thickness chondral defects with an acellular hydrogel containing SDF-1α. We expect that SDF-1α can increase the re

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13

Motavalli, Sayyed Mostafa. "DEPTH-DEPENDENT BIAXIAL MECHANICAL BEHAVIOR OF NATIVE AND TISSUE ENGINEERING ARTICULAR CARTILAGE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1390313405.

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14

Nettles, Dana Lynn. "Evaluation of chitosan as a cell scaffolding material for cartilage tissue engineering." Master's thesis, Mississippi State : Mississippi State University, 2001. http://library.msstate.edu/etd/show.asp?etd=etd-10262001-114635.

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15

Barnes, Catherine Pemble. "Design of an Electrospun Type II Collagen Scaffold for Articular Cartilage Tissue Engineering." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/1393.

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16

Heymer, Andrea. "Chondrogenic differentiation of human mesenchymal stem cells and articular cartilage reconstruction." kostenfrei, 2008. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2008/2944/.

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17

Hunter, Christopher John. "Mechanical stimulation of an in vitro articular cartilage defect repair model." Diss., Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/20162.

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18

Knight, Martin Matthew. "Deformation of isolated articular chondrocytes cultured in agarose constructs." Thesis, Queen Mary, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267531.

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19

Capito, Ramille M. (Ramille Marie). "Gene-supplemented collagen-glycosaminoglycan scaffolds for nonviral gene delivery in articular cartilage tissue engineering." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/36203.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006.<br>Includes bibliographical references.<br>Three-dimensional scaffolds and growth factors have been shown to be important for articular cartilage tissue engineering. A major problem in using recombinant proteins in vivo, however, is the inability to maintain therapeutic levels over prolonged times due to degradation or diffusion from the defect site. The goal of this thesis was to develop a method to employ type II collagen-glycosaminoglycan (CG) scaffolds for the nonviral delivery of the

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20

Saini, Sunil. "Bioreactor for the production of tissue engineered cartilage : defining operating parameters for optimal construct growth." Diss., Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/10226.

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21

Balcom, Nathan Thomas. "MATRIX REMODELING ACCOMPANIES IN VITRO ARTICULAR CARTILAGE SPHERICAL SHAPING." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/976.

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Introduction: Articular cartilage (AC) is a low friction load bearing material found in synovial joints. The natural repair of damaged tissue is difficult and often requires surgical intervention. With large defects it becomes necessary to match the original tissue geometry. We hypothesized that localized collagen (COL) and/or proteoglycan (PG) remodeling occurs during AC spherical reshaping. The objective of this study was to determine the presence, magnitude and depth dependence of COL and PG remodeling that accompanies AC reshaping. Methods: Full thickness AC blocks (7x7 mm2 surface area) w

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22

Ramalho, Gonçalo da Costa. "Development and optimization of biomimetic PCL electrospun scaffolds for cartilage tissue engineering." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22572.

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mestrado em Materiais e Dispositivos Biomédicos<br>As lesões na cartilagem articular são um grande problema da sociedade actual. A engenharia de tecidos da cartilagem é uma alternativa emergente aos procedimentos da medicina tradicional, produzindo estruturas porosas biomiméticas capazes de mimetizar a organização estrutural das fibras de colagénio, dependentes de profundidade, da cartilagem articular nativa. O presente trabalho, pretendia não só optimizar o tamanho dos poros da estrutura fibrosa electrofiada das várias zonas que compõem as estruturas porosas 3D anisotrópicas, desenvolvidas an

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23

Mouw, Janna Kay. "Mechanoregulation of chondrocytes and chondroprogenitors the role of TGF-BETA and SMAD signaling /." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-11232005-103041/.

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Thesis (Ph. D.)--Bioengineering, Georgia Institute of Technology, 2006.<br>Harish Radhakrishna, Committee Member ; Christopher Jacobs, Committee Member ; Andres Garcia, Committee Member ; Marc E. Levenston, Committee Chair ; Barbara Boyan, Committee Member.

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24

Vail, Daniel Joseph. "Mapping the Way Toward an Engineered Articular Cartilage:A Complete Transcriptional Characterization of Native and MSC-Derived Cartilage." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case162644731682198.

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25

Kinney, Ramsey Christian. "The role of sexual dimorphism in cartilage tissue regeneration." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/28225.

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Thesis (M. S.)--Biomedical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Boyan, Barbara; Committee Member: Bonassar, Lawrence; Committee Member: Sambanis, Anthanassios; Committee Member: Schwartz, Zvi; Committee Member: Wick, Timothy.

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26

Brouillette, Marc James. "Static compressive stress induces mitochondrial oxidant production in articular cartilage." Thesis, University of Iowa, 2012. https://ir.uiowa.edu/etd/2445.

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While mechanical loading is essential for articular cartilage homeostasis, it also plays a central role in the etiology of osteoarthritis. The mechanotransduction events underlying these dual effects, however, remain unclear. Previously, we have shown that lethal amounts of reactive oxygen species (ROS) were liberated from mitochondrial complex 1 in response to a mechanical insult. The sensitivity of this response to an actin polymerase inhibitor, cytochalasin B, indicated a link between ROS release and cytoskeletal distortion caused by excessive compressive strain. It did not, however, rule o

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27

Vanderploeg, Eric James. "Mechanotransduction in Engineered Cartilaginous Tissues: In Vitro Oscillatory Tensile Loading." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-05192006-110158/.

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Thesis (Ph. D.)--Mechanical Engineering, Georgia Institute of Technology, 2007.<br>Radhakrishna, Harish, Committee Member ; LaPlaca, Michelle, Committee Member ; Nerem, Robert, Committee Member ; Garcia, Andres, Committee Member ; Levenston, Marc, Committee Chair.

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28

Moeini, Mohammad. "Solute transport in articular cartilage: toward applications of diffusion, partitioning and adsorption for tissue functional assessment." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119628.

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This thesis examines aspects of solute partitioning and diffusion in articular cartilage and solute adsorption to its surfaces, and discusses their potential applications in functional assessment of cartilage. Investigation of temperature dependence of solute transport in cartilage showed general trends of increased partition coefficient and diffusivity with increasing temperature for a range of fluorescent solutes including fluorescein isothiocyanate, 4 and 40 kDa dextrans, myoglobin, insulin and chondroitin sulfate. Unexpected behaviours of some solutes and small but significant changes in w

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29

Farooque, Tanya Mahbuba. "Biochemical and mechanical stimuli for improved material properties and preservation of tissue-engineered cartilage." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26710.

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Thesis (Ph.D)--Chemical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Boyan, Barbara; Committee Chair: Wick, Timothy; Committee Member: Brockbank, Kelvin; Committee Member: Nenes, Athanasios; Committee Member: Sambanis, Athanassios. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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30

Accardi, Mario Alberto. "Numerical and experimental characterisation of articular cartilage : a study on biomechanics and biotribology, osteoarthritis and tissue engineering solutions." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11042.

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Articular Cartilage (AC) is a soft tissue covering the articulating surface of human and animal joints. The tissue has remarkable and highly complex mechanical and wear properties allowing the joint to undergo complex kinematics and function correctly for several decades. However, trauma and degenerative joint diseases such as osteoarthritis (OA) can cause damage and excessive wear of the tissue and due to its limited regenerative capabilities, can severely compromise joint movement and impair the quality of life. OA is the most common type of degenerative joint disease and the primary cause o

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31

Dua, Rupak. "Enhanced Anchorage of Tissue-Engineered Cartilage Using an Osteoinductive Approach." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/context/etd/article/2559/type/native/viewcontent.

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Articular cartilage injuries occur frequently in the knee joint. Several methods have been implemented clinically, to treat osteochondral defects but none have been able to produce a long term, durable solution. Photopolymerizable cartilage tissue engineering approaches appear promising; however, fundamentally, forming a stable interface between the tissue engineered cartilage and native tissue, mainly subchondral bone and native cartilage, remains a major challenge. The overall objective of this research is to find a solution for the current problem of dislodgment of tissue engineered cartila

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32

Owen, John. "DEVELOPMENT OF PHYSIOLOGIC CONTACT MODELS FOR ARTICULAR SURFACES." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2444.

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The superficial tangential zone (STZ) plays a significant role in normal articular cartilage’s ability to support loads and retain fluids. To date, tissue engineering efforts have not replicated normal STZ function in cartilage repairs. Finite element models were developed to examine the STZ’s role in normal and repaired articular surfaces under different contact conditions. Models were developed by incrementally adding improvements which culminated in contact loading of curved models by permeable and impermeable rigid surfaces and a normal cartilage layer. In the normal STZ, permeability

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33

Pyle, Jeffrey D. "Development and validation of a human hip joint finite element model for tissue stress and strain predictions during gait." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1131.

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Articular cartilage degeneration, called osteoarthritis, in the hip joint is a serious condition that affects millions of individuals yearly, with limited clinical solutions available to prevent or slow progression of damage. Additionally, the effects of high-risk factors (e.g. obesity, soft and hard tissue injuries, abnormal joint alignment, amputations) on the progression of osteoarthritis are not fully understood. Therefore, the objective of this thesis is to generate a finite element model for predicting osteochondral tissue stress and strain in the human hip joint during gait, with a futu

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34

Sucosky, Philippe. "Flow Characterization and Modeling of Cartilage Development in a Spinner-Flask Bioreactor." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6875.

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Bioreactors are devices used for the growth of tissues in a laboratory environment. They exist in many different forms, each designed to enable the production of high-quality tissues. The dynamic environment within bioreactors is known to significantly affect the growth and development of the tissue. Chondrocytes, the building blocks of articular cartilage, for example, are stimulated by mechanical stresses such as shear, as compared with those in tissues grown under static incubation conditions. On the other hand, high shear can damage cells. Consequently the shear-stress level has to be cont

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35

Huang, Henry. "Exploring New Therapeutic Strategies for Osteoarthritis: From Genetic Manipulation of Skeletal Tissues to Chemically-modified Synthetic Hydrogels." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/919.

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Osteoarthritis (OA), a degenerative disease of articular joints, is the leading cause of chronic disability in the US and affects more than a third of adults over 65 years old. Due to the obesity epidemic and an aging population, the prevalence of OA is expected to rise in both young and old adults. There are no disease modifying OA drugs. Therefore, providing any treatment options that delay the onset or progression of OA is highly desirable. The scope of this dissertation examines two different strategies to promote translational therapies for OA. The first approach investigated whether Smad

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36

Shafieyan, Yousef. "Mechanical stimulation of orthopaedic tissues: regulation of bone resorption and solute transport through articular cartilage." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119625.

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Orthopaedic tissues such as bone, cartilage, ligament, tendon and muscle serve primarily mechanical roles in support of controlled movement. These tissues must continually adapt to changes in their physical environments, in a lifelong process termed remodelling. Interactions between cells in orthopaedic tissues and their physical surroundings underlie tissue functions, remodelling, responses to injury, diseases and repair. Osteoclasts are a type of bone cell responsible for bone resorption. Effects of mechanical stimulation on osteoclast differentiation and subsequent bone resorption activity

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37

Griebel, Matthew Alexander. "Viscoelastic Anisotropic Finite Element Mixture Model of Articular Cartilage using Viscoelastic Collagen Fibers and Validation with Stress Relaxation Data." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/743.

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Experimental results show that collagen ﬁbers exhibit stress relaxation under tension and a highly anisotropic distribution. To further develop the earlier model of Stender [1], the collagen constituent was updated to reﬂect its intrinsic viscoelasticity and anisotropic distribution, and integrated with an existing mixture model with glycosaminoglycans and ground substance matrix. A two-term Prony series expansion of the quasi-linear viscoelastic model was chosen to model the viscoelastic properties of the collagen ﬁbers. Material parameters were determined by using the simplex method to minim

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Shields, Kelly J. "The Development of a Multi-Directional Wear Apparatus and the Characterization and Correlation of Biomechanical and Biotribological Properties of Bovine Articular Cartilage." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd/1271.

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A multi-directional wear apparatus was developed to simulate the kinematic motion of diarthrodial joints. A comprehensive evaluation including biotribological and biomechanical characterization of articular surfaces was performed with concomitant translational and oscillating rotational motion similar to that experienced in vivo. Various system parameters were evaluated in the designed experiments including normal load magnitude (high/low), surface quality (defect/no defect), and wear pattern (with/without rotation). Biomechanical characterization was achieved through stress relaxation and dyn

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39

Yang, Yueh-Hsun. "Development of hydrodynamically engineered cartilage in response to insulin-like growth factor-1 and transforming growth factor-beta1: formation and role of a type I collagen-based fibrous capsule." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/49072.

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Articular cartilage which covers the surfaces of synovial joints is designed to allow smooth contact between long bones and to absorb shock induced during joint movement. Tissue engineering, a means of combining cells, biomaterials, bioreactors and bioactive agents to produce functional tissue replacements suitable for implantation, represents a potential long-term strategy for cartilage repair. The interplay between environmental factors, however, gives rise to complex culture conditions that influence the development of tissue-engineered constructs. A fibrous capsule that is composed of abun

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Wangerin, Spencer D. "Development and validation of a human knee joint finite element model for tissue stress and strain predictions during exercise." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1129.

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Osteoarthritis (OA) is a degenerative condition of cartilage and is the leading cost of disability in the United States. Motion analysis experiments in combination with knee-joint finite element (FE) analysis may be used to identify exercises that maintain knee-joint osteochondral (OC) loading at safe levels for patients at high-risk for knee OA, individuals with modest OC defects, or patients rehabilitating after surgical interventions. Therefore, a detailed total knee-joint FE model was developed by modifying open-source knee-joint geometries in order to predict OC tissue stress and strain d

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Petitjean, Noémie. "Nouveau dispositif fluidique pour la stimulation et la caractérisation biomécanique de microsphères : preuve de concept et application aux micropellets de cartilage." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT047.

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Les pathologies du cartilage articulaire (CA) constituent aujourd’hui un problème de santé publique. L’ingénierie tissulaire, dont l’objectif est la création de nouveaux tissus contenant des cellules, est une solution thérapeutique prometteuse pour la réparation de lésions du CA mais nécessite encore des recherches pour améliorer les propriétés mécaniques des néo-tissus. Ce travail de thèse avait pour objectif l’analyse de l’impact de stimulations mécaniques sur le développement et le maintien du CA. Le micropellet de cartilage, conçu à partir de l’agrégation de cellules souches mésenchymateus

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Bostan, Luciana Elena. "Matériaux polymères avec hydrophilie contrôlée. Applications en ingénierie tissulaire du cartilage articulaire." Phd thesis, INSA de Lyon, 2011. http://tel.archives-ouvertes.fr/tel-00743464.

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Les maladies ostéoarticulaires représentent environ 10% de l'ensemble des pathologies identifiées en France chaque année. Ces maladies inflammatoires et dégénératives des articulations sont pour la plupart consécutives au vieillissement ou à un traumatisme et évoluent vers l'usure des cartilages, d'où un handicap sévère. Comme aucun traitement ne permet la réparation totale du tissu cartilagineux, la recherche médicale développe des techniques d'ingénierie tissulaire. Ces techniques utilisent des substrats polymériques et des cellules souches qui sont " contraints " de se développer pour forme

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43

Ylärinne, Janne. "Production of neocartilage tissues using primary chondrocytes." Doctoral thesis, Umeå universitet, Histologi med cellbiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-113929.

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Hyaline cartilage is a highly specialized tissue, which plays an important role in the articulating joints of an individual. It provides the joints with a nearly frictionless, impact resisting surface to protect the ends of the articulating bones. Articular cartilage has a poor self-repair capacity and, therefore, it rarely heals back to normal after an injury. Overweight, injuries, overloading and genetic factors may initiate a degenerative disease of the joint called osteoarthritis. Osteoarthiritis is a major global public health issue. Currently, the most used treatment for large articular

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Martínez, Díaz Santos. "Reparació de lesions condrals mitjançant suports macroporosos biodegradables tridimensionals de policaprolactona. estudi experimental en un model animal." Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/285170.

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Com és ben conegut, el cartílag hialí articular té una capacitat de reparació molt limitada. Les lesions condrals són causa de dolor, rigidesa, disminució de moviment i finalment destrucció de l’articulació. Els tractaments clàssics de reparació es basen en el transplantament osteocondral o en l’estimulació del sagnat subcondral per a produir una reparació secundària al reclutament de cèl·lules mare pluripotencials. Des de fa uns 20 anys, es van publicar els primers resultats clínics de la reparació de lesions condrals mitjançant el transplantament de condròcits autòlegs (ACI). Aquesta t

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Khaghani, Seyed A. "Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/5371.

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Articular cartilage is an avascular and flexible connective tissue found in joints. It produces a cushioning effect at the joints and provides low friction to protect the ends of the bones from wear and tear/damage. It has poor repair capacity and any injury can result pain and loss of mobility. One of the common forms of articular cartilage disease which has a huge impact on patient¿s life is arthritis. Research on cartilage cell/tissue engineering will help patients to improve their physical activity by replacing or treating the diseased/damaged cartilage tissue. Cartilage cell, called chon

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Khaghani, Seyed Ali. "Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins : effect of transforming growth factor-beta (TGF-β1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins". Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/5371.

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Articular cartilage is an avascular and flexible connective tissue found in joints. It produces a cushioning effect at the joints and provides low friction to protect the ends of the bones from wear and tear/damage. It has poor repair capacity and any injury can result pain and loss of mobility. One of the common forms of articular cartilage disease which has a huge impact on patient's life is arthritis. Research on cartilage cell/tissue engineering will help patients to improve their physical activity by replacing or treating the diseased/damaged cartilage tissue. Cartilage cell, called chond

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Sitterle, Valerie B. "Photoactivated Fixation of Cartilage Tissue." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/7609.

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Cartilage repair and/or replacement is necessary for many orthopaedic conditions including fissures from blunt trauma, autograft or allograft transplantation, and replacement of focal defects with biological or synthetic constructs. In cartilage repair, initial integration between the host tissue and repair site is desirable to allow for nutrient transport, molecular deposition to enhance fixation, and eventual stress transmission across the interface. It has been postulated that effective transport and crosslinking of newly synthesized collagen molecules across a repair site may be vital to

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Arora, Arvind. "Potential of qMRI in the study of articular cartilage and cartilage repair tissue." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613644.

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Razaq, Mohammed Sajjad. "The effect of extracellular pH on cartilage tissue metabolism and turnover." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249606.

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Tang, Xiaodi. "The role of connective tissue growth factor (CTGF) in articular cartilage." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/25292.

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Work from our group has identified an important role for the pericellular matrix (PCM) of cartilage in mechanotransduction. This region of the matrix sequesters regulatory molecules such as fibroblastic growth factor 2 (FGF2) and releases them upon mechanical stimulation. By carrying out a proteomic analysis of PCM proteins we identified an additional regulatory molecule, connective tissue growth factor (CTGF). CTGF was of interest to us as this protein is up-regulated in osteoarthritis but its function in chondrocytes is unknown. I confirmed the pericellular localisation of CTGF in cartilage

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