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1

Dawson, Jennifer Elizabeth. "Cardiac Tissue Engineering." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20071.

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The limited treatment options available for heart disease patients has lead to increased interest in the development of embryonic stem cell (ESC) therapies to replace heart muscle. The challenges of developing usable ESC therapeutic strategies are associated with the limited ability to obtain a pure, defined population of differentiated cardiomyocytes, and the design of in vivo cell delivery platforms to minimize cardiomyocyte loss. These challenges were addressed in Chapter 2 by designing a cardiomyocyte selectable progenitor cell line that permitted evaluation of a collagen-based scaffold f
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2

Somasundaram, Murali. "Intestinal tissue engineering." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:54e0f17f-fe04-4012-b0d3-04f436e9af9a.

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Tissue engineering (TE) principles have been successfully clinically applied to treat disease affecting specific organs (e.g. trachea) but developments in some organs has lagged behind. The inability to repair or replace significantly damaged intestinal tissue remains a barrier to improving patient outcomes and the promise of Tissue Engineered Intestine (TEI) that was first made more than 20 years ago, is yet to be realised. This work explored the potential of TEI and literature review formed a basis for developing a clinically transferrable experimental model. It was hypothesised that, porcin
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3

BERNOCCO, MARCO. "Bioreactor engineering for tissue engineering application." Doctoral thesis, Politecnico di Torino, 2013. http://hdl.handle.net/11583/2513796.

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Lo scopo di questo lavoro di tesi è la caratterizzazione metrologica di un bioreattore con l’intento di aumentare la riproducibilità e l’affidabilità dei processi di Ingegneria tessutale (Tissue Engineering, TE). La Tissue engineering (TE) o ingegneria dei tessuti è la disciplina che studia la comprensione dei principi della crescita dei tessuti, e la loro applicazione per produrre tessuto funzionale per uso clinico o diagnostico. Uno dei principali scopi della TE è l’impiego di tessuti in crescita naturale extracorporea per la medicina rigenerativa, in altre parole lo sviluppo di strategie te
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4

Rouwkema, Jeroen. "Prevascularized bone tissue engineering." Enschede : University of Twente [Host], 2007. http://doc.utwente.nl/57929.

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5

Mirsadraee, Saeed. "Tissue engineering of pericardium." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426783.

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6

Getgood, Alan Martin John. "Articular cartilage tissue engineering." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608764.

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7

Tseng, Yuan-Tsan. "Heart valve tissue engineering." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:e67c780d-d60f-42e7-9311-dd523f9141b3.

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Since current prosthetic heart valve replacements are costly, cause medical complications, and lack the ability to regenerate, tissue-engineered heart valves are an attractive alternative. These could provide an unlimited supply of immunological-tolerated biological substitutes, which respond to patients' physiological condition and grow with them. Since collagen is a major extra cellular matrix component of the heart valve, it is ideal material for constructing scaffolds. Collagen sources have been shown to influence the manufacturing of collagen scaffolds, and two commercial sources of colla
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8

Aor, Bruno. "Engineering microchannels for vascularization in bone tissue engineering." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0430/document.

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In vitro, la formation de structures de type tubulaire avec des cellules endothéliales de veine ombilicale humaine (HUVEC) a été étudiée en combinant la fonctionnalisation de la chimie des matériaux et le développement de la géométrie tridimensionnelle. Le polycarbonate (PC) a été utilisé comme modèle pour le développement de l'échafaud. Le film de polysaccharide naturel, basé sur un dépôt alternatif couche par couche (LbL) d’acide hyaluronique (HA) et de chitosane (CHI), a d’abord été appliqué sur une surface PC et caractérisé en termes de croissance d’épaisseur microscopie à balayage lascar
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9

Sodian, Ralf. "Tissue-Engineering von kardiovaskulären Geweben." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974660175.

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10

Kamei, Yuzuru, Kazuhiro Toriyama, Toru Takada, and Shunjiro Yagi. "Tissue-Engineering Bone from Omentum." Nagoya University School of Medicine, 2010. http://hdl.handle.net/2237/14172.

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11

Czechura, Pawel. "Saturated neoglycopolymers for tissue engineering." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27121.

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Norbornene monomers bearing carbohydrate groups of relevance for tissue engineering were synthesized via the norbornene acid chlorides, transformed into their ROMP polymers, and reduced to yield saturated neoglycopolymers. These materials bear either O-glycoside groups designed to cross-link collagen via reaction of the ring-open sugar with free NH2 groups of lysine, or C-glycoside groups. The latter are intended for use as the central block in triblock copolymers terminated with blocks capable of crosslinking: they serve only as potentially biocompatible "spacers" to help span the interlamell
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12

Hussain, Timon. "Tissue Engineering mit porösen Polyethylenimplantaten." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-162027.

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Hintergrund: Eine Verbesserung der Biokompatibilität von porösen Polyethylenimplantaten könnte postoperative Komplikationsraten senken und das klinisches Anwendungsgebiet des Biomaterials erweitern. Im Rahmen dieser Studie wurde untersucht, ob eine „Vitalisierung“ von porösen Polyethylenimplantaten mit dermalen Fibroblasten möglich ist und ob hierdurch die mikrovaskuläre Integration sowie die immunologische Reaktion des Wirtsorganismus beeinflusst werden konnte. Material und Methoden: Poröse Polyethylenimplantate wurden in vitro mit GFP-markierten dermalen Fibroblasten kultiviert. Die auf de
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13

Cooper, Leanne Jane. "Tissue engineering of the cornea." Thesis, Lancaster University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421611.

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14

Wung, Nelly. "Tissue engineering of the liver." Thesis, University of Bath, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715264.

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Currently, the only cure for liver failure is orthotopic liver transplantation. However, there are insufficient donor organs available to treat every patient on the transplant list and many die before they are able to receive a liver transplant. The bioartificial liver (BAL) device is a potential extracorporeal treatment strategy utilising hepatocytes or hepatocyte-like cells (HLCs) within a bioreactor to recapitulate normal liver function and therefore ‘bridge’ a patient with liver failure until they receive a transplant. The work in this thesis utilised tissue engineering methods to develop
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15

Mehrban, Nazia. "Tissue engineering a ligamentous construct." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2989/.

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Tendon and ligament damage causes extreme pain and decreased joint functionality. Current repair methods cannot restore original joint biomechanics nor promote regeneration of native tissue. Recent advances in tendon and ligament repair have involved engineering tissue using cell-seeded scaffolds. Self-aligned cellular structures, similar to those in ligaments and tendons, have been successfully formed, albeit with weak attachment between construct and bone. Calcium phosphates form an intimate bond with both soft and hard tissues and have successfully been used in tissue engineering bone, whil
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16

Schrader, S. "Tissue engineering for conjunctival reconstruction." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1348133/.

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Reconstruction of the conjunctiva is an essential part of ocular surface regeneration, especially if an extensive area or the whole ocular surface is affected, such as in patients with ocular cicatricial pemphigoid, Stevens- Johnson syndrome or chemical/thermal burns. However, there is a lack of suitable donor tissue for conjunctival replacement, especially when large grafts are required and it is important that new materials and methods are developed for conjunctival reconstruction. The aims of this thesis were; to characterise the conjunctival epithelial cell population and to improve the ma
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17

Qiu, Yiwei. "In vitro tendon tissue engineering." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:10d2b8fe-c485-44e4-ba03-abdad0da48f7.

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Tendon, ligament, and joint capsular injuries represent 45% of the 32 million musculoskeletal injuries each year in the United States. Tendon injuries are especially common, requiring surgical repair for the shoulder’s rotator cuff tendons (51,000 per year), the Achilles tendon (44,000 per year), and the patellar tendon (42,000 per year). Tissue engineering provides an alternative in the treatment of tendon lesions through replacement of an injured tendon segment. The purpose of this study was to develop a tendon construct in vitro for clinical reconstructive surgery. Human tenocytes were isol
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18

Muhamad, Farina. "Electrospun scaffolds for tissue engineering." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14577.

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A critical challenge in designing materials for tissue engineering (TE) is to provide essential cues that can control cellular behaviour and promote tissue regeneration. TE with fibrous scaffolds by using electrospinning is emerging as a major research area in the field of regenerative medicine. This thesis presents the development of novel electrospun fibrous acrylate scaffolds for bone TE. Acrylate fibrous scaffolds were developed by electrospinning photocrosslinkable and low molecular weight acrylate monomers, methyl acrylate (MA) and diethylene-glycol dimethacrylate (DEGMA). Photocrosslink
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19

Place, Elsie Sarah. "Bioactive hydrogels for tissue engineering." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/7106.

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Modern tissue engineering (TE) scaffolds are expected to actively promote tissue repair as well as meeting the traditional requirements of non-toxicity, degradability and structural integrity. This thesis presents two novel bioactive hydrogel systems for bone and cartilage TE. A series of alginate hydrogels were developed in which all or a fraction of the calcium normally used for crosslinking alginate was replaced by bioactive strontium and/or zinc ions. Strontium was chosen for its ability to stimulate bone formation, while zinc is essential for alkaline phosphatase activity. Due to an inter
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20

Sodian, Ralf. "Tissue Engineering von kardiovaskulären Geweben." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/13965.

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Beim Tissue Engineering werden Erkenntnisse aus der Medizin, Biologie und Chemie mit Methoden der Ingenieurwissenschaften kombiniert, um biologische Ersatzgewebe herzustellen. Das Konzept besteht darin, aus körpereigenen Zellen einen vitalen und funktionalen Gewebeersatz zu fertigen. Hierbei werden körpereigene Zellen auf ein resorbierbares Gerüst transplantiert, in vitro zu einer stabilen Struktur gefestigt, um letztendlich ein vitales Ersatzgewebe implantieren zu können. Die Konstrukte für die menschliche Herzchirurgie sollten in das umgebende Gewebe einwachsen und haben das Potential sich w
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21

SCARPA, TOMMASO. "BIOPOLYMERS FOR CARTILAGE TISSUE-ENGINEERING." Doctoral thesis, Università degli studi di Trieste, 2007. http://thesis2.sba.units.it/store/handle/item/12302.

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22

FACCENDINI, ANGELA. "NANOCOMPOSITE SCAFFOLDS FOR TISSUE ENGINEERING." Doctoral thesis, Università degli studi di Pavia, 2021. http://hdl.handle.net/11571/1447787.

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Lo scopo del progetto è stata la progettazione e lo sviluppo di scaffold elettrofilati ibridi a base di polisaccaridi e glicosaminoglicani con particelle minerali incluse nella matrice nanofibrosa. Gli scaffold sono stati destinati all'ingegneria dei tessuti dermici o tendinei. Gli scaffold dermici sono stati caricati con montmorillonite o alloisite, come dispositivi medici. Inoltre, sono stati sviluppati scaffold caricati con un nanocomposito di norfloxacina-montmorillonite per trattare e prevenire le infezioni delle ferite. Sono stati sviluppati anche scaffold tubolari, come impianto nella c
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23

RIVA, LEONARDO. "Biomanufacturing Technologies for Tissue Engineering." Doctoral thesis, Università degli studi di Brescia, 2023. https://hdl.handle.net/11379/571155.

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Il seguente lavoro di tesi ha come obiettivo lo studio e la realizzazione di device biomedicali realizzati tramite la manifattura additiva. La manifattura additiva sta avendo una forte crescita negli ultimi anni grazie soprattutto alla possibilità di realizzare facilmente geometrie complesse. Questa caratteristica permette di personalizzare i prodotti ad un costo competitivo. Inoltre, lo spreco di materiale viene ridotto moltissimo dal principio di fabbricazione. Tutte queste proprietà hanno fatto in modo che negli ultimi anni la manifattura additiva prendesse sempre più piede in campi come l’
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24

Sidney, Laura E. "Tissue engineering in hostile environments : the effects and control of inflammation in bone tissue engineering." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13499/.

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The potential effects of introducing bone regeneration strategies into environments of disease and damage are often overlooked, despite the fact that many of the signalling pathways in inflammation have effects on bone development and healing. Embryonic stem cells (ESCs) are increasingly being used to develop models of disease and have potential in osteogenic-cell based therapies. Osteogenic differentiation strategies for ESCs are well established, but the response of these cells to tissue damage and inflammation has not yet been investigated, particularly in comparison to primary osteoblasts.
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25

Ghezzi, Chiara Elia. "Dense collagen-based tubular tissue constructs for airway tissue engineering." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114489.

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To date, only engineered tissues of planar geometry, such as epidermal and dermal layer substitutes, have successfully reached the market, mainly due to their relative low complexity and simple geometry. In contrast, the mechanical and functional requirements of tubular tissues are more stringent compared to planar tissues. Tubular tissues, which are the main components of several biological systems (e.g. circulatory, urinary or respiratory), not only present an increased complexity in geometry and tissue architecture, they are also populated by mixed cell types. In addition, these are continu
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Chik, Tsz-kit, and 戚子傑. "Fabrication of multi-component tissue for intervertebral disc tissue engineering." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47849447.

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Intervertebral disc tissue engineering is challenging because it involves the integration of multiple tissues with distinct structures and compositions such as lamellar annulus fibrosus, gel?like nucleus pulposus and cartilage endplate. Each of them has different compositions and different structures. It is hypothesized that integration of tissues can be enhanced with appropriate mechanical and biological stimuli. Meanwhile, effect of torsional stimulus on cell re?orientation in mesenchymal stem cell?collagen tubular constructs is investigated in this study. Furthermore, it is proposed
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27

Le, Thua Trung Hau. "Multimodality Treatment of Soft Tissue and Bone Defect: from Tissue Transfer to Tissue Engineering." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/220961.

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In the first part of these studies, we have performed standard microsurgical procedures provide a solution for long standing bone and soft tissue defects, even in cases of longstanding osteomyelitis of long bones. When long bony segments are missing, the microvascular bone transfer provides a reliable method. In smaller soft tissue and bone defects, the application of a descending genicular osteomyocutaneous flap provides an option with low donor site morbidity. In the second part, we have focussed on reducing the donor site morbidity and expanded on the application of tissue engineering metho
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28

Ueda, Yuichiro. "Application of Tissue Engineering with Xenogenic Cells and Tissues for Regenerative Medicine." 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/147657.

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29

Yang, Chao. "Tissue engineering of human cardiovascular patches." [S.l.] : [s.n.], 2005. http://www.diss.fu-berlin.de/2005/103/yang.pdf.

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30

Ndreu, Albana. "Electrospun Nanofibrous Scaffolds For Tissue Engineering." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608226/index.pdf.

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In this study a microbial polyester, poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV), and its blends were wet or electrospun into fibrous scaffolds for tissue engineering. Wet spun fiber diameters were in the low micrometer range (10-50 &amp<br>#956<br>m). The polymer concentration and the stirring rate affected the properties the most. The optimum concentration was determined as 15% (w/v). Electrospun fiber diameters, however, were thinner. Solution viscosity, potential, distance between the syringe tip and the collector, and polymer type affected the morphology and the thickness of bead
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31

Ziegelaar, Brian. "Tissue engineering of a tracheal substitute." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-18187.

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32

Junker, Johan. "Human Dermal Fibroblasts in Tissue Engineering." Doctoral thesis, Linköpings universitet, Cellbiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19716.

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The loss or failure of tissues and/or organs is one of the most frequent problems in modern healthcare. The field of tissue engineering applies the principles of biology and engineering in order to develop functional substitutes for damaged tissues. Tissue engineering contains elements of medicine, material science and engineering with major components in focus being cells, biomaterials and soluble factors. All three components may be required for the development of clinical treatments. The usage of autologous tissue specific cells for clinical treatment is often not feasible due to poor growt
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33

Tse, Christopher Chi Wai. "Utilising inkjet printing for tissue engineering." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/13950/.

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The field of tissue engineering has the potential to improve the quality of life of individuals through combining the knowledge of engineering and life sciences in creating engineered biological substitutes that repair, support and enhance tissue function. Inkjet printing is a versatile tool that can be used for a broad range of applications. Ubiquitous in households, offices and industry, there has been growing interest in the use of inkjet printing for biological applications. Inkjet printing allows the user to deposit nano-picolitre volume of inks of low viscosity with high precision and hi
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34

Holy, Chantal E. "Bone tissue engineering on biodegradable polymers." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0012/NQ59097.pdf.

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35

Sachlos, Eleftheherios. "Tissue engineering with solid freeform fabrication." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418645.

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36

Qiao, Xiangchen. "Scaffold fabrication for bone tissue engineering." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550345.

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An ideal engineered scaffold should support the regeneration of natural extracellular matrix; for bone this is principally Type I collagen and hydroxyapatite. The present work investigated the fabrication and characterisation of scaffolds comprised of (a) PCL or (b) Type I collagen +/- PDLLA produced via electrospinning and studied their influence on osteogenic regeneration. A parallel study examined the cellular response of human bone marrow stromal cells to nano-crystalline hydroxyapatite particles in a foamed PDLLA scaffold. Both the influence of particle size and chemical substitution were
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Blackwood, Keith Alan. "Electrospun scaffolds for soft tissue engineering." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548559.

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38

Arumugam, M. Q. "Porous scaffolds for bone tissue engineering." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596173.

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The aim of this thesis is to investigate the behaviour of cells in porous scaffolds. Three types of porous scaffold were investigated; porous phase-pure hydroxyapatite, porous silicon-substituted hydroxyapatite and a novel mineralised (brushite) collagen-glycosaminoglycan (GAG) scaffold. Methods were derived to optimise the seeding of cells within these scaffolds and the differentiation of bone and marrow-derived cells in short-term culture was investigated using molecular biology and ELISA techniques. Novel techniques were developed to assess the response of cells within the centre of the sca
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Teichmann, Juliane. "Tissue Engineering des Humanen Cornealen Endothels." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-131578.

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Das corneale Endothel bildet die innere, einschichtige Zelllage der Cornea und ist für die Aufrechterhaltung der cornealen Transparenz zuständig. Krankheiten oder Verletzungen des cornealen Endothels können zu schweren Beeinträchtigungen des Sehvermögens führen und eine corneale Transplantation erforderlich machen. Der während und nach der Operation auftretende endotheliale Zellverlust erschwert das Überleben des Transplantates. Darum besteht ein Hauptziel des cornealen Tissue Engineerings in der Bereitstellung von transplantierbaren humanen cornealen Endothelzellsheets (HCEC-Sheets) mit einer
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Herrmann, P. "Tissue engineering of upper airway replacements." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1533028/.

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Laryngotracheal diseases cause considerable morbidity and fully functional replacement after extensive surgical resection is still missing. Regenerative medicine has made considerable progress towards clinical transplantation and offers a potentially attractive solution. To date the use of biological scaffolds is considered promising for tissue engineering, providing structural and microbiological support for cell seeding and integration in the host environment. This thesis investigates the possibility of developing a decellularization protocol suitable for the production of upper airway const
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41

Kocaba, Viridiana. "Tissue engineering pour la reconstruction cornéenne." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1078.

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En France, les dysfonctions endothéliales représentent environ la moitié des indications de greffes de cornée réalisées chaque année. Cependant, les problématiques liées à la pénurie de greffon, aux difficultés des techniques chirurgicales de greffes endothéliales ainsi qu’aux risques d’échec ou de rejet de greffe poussent les chercheurs à développer de nouvelles thérapies moins invasives et plus efficaces. La thérapie cellulaire cornéenne endothéliale est une des voies de recherche actuellement explorées dont le but est de s’affranchir des aléas de la greffe de cornée. La cornée humaine est u
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42

Radisic, Milica. "Biomimetic approach to cardiac tissue engineering." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28665.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2004.<br>"September 2004."<br>Includes bibliographical references.<br>(cont.) biochemical and morphological properties in the pretreated group. Finally, in order to mimic capillary structure cardiac fibroblasts and myocytes were co-cultured on a scaffold with a parallel channel array that was perfused with culture medium supplemented with synthetic oxygen carrier (PFC emulsion). Presence of the PFC emulsion resulted in significantly higher cell density and improved contractile properties compared to the cons
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Ling, Yibo. "Hydrogel cell encapsulation for tissue engineering." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44456.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2008.<br>Vita.<br>Includes bibliographical references (leaves 116-123).<br>The engineering of artificial tissues for restoration or replacement of organ function holds the potential to alter the landscape of medical therapeutics. In many tissue engineering approaches, cells seeded within 3D porous structures are expected to remodel into tissue-like structures. Despite significant progress, difficulties in lack of control over tissue architecture as well as vascularization continue to lim
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Carrier, Rebecca Lyn 1973. "Cardiac tissue engineering : bioreactor cultivation parameters." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/8999.

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Thesis (Sc.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2000.<br>Includes bibliographical references.<br>Tissue engineering may be useful in fighting heart disease since it offers the possibility of creating functional tissue equivalents for scientific studies and tissue repair. In the present work, we examined how variations in cultivation parameters of a model tissue engineering system influenced cardiac tissue morphogenesis. The central hypothesis was that using a tissue engineering system consisting of isolated cardiac cells, polymer scaffolds, and tissue cult
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Li, Siwei. "Cartilage tissue engineering : a multidisciplinary approach." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/407512/.

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Degeneration of articular cartilage and associated osteoarthritic changes are the leading cause of compromised joint articulation worldwide. Early stages of osteoarthritis (OA) are characterised by partial thickness chondral defects that fail to heal spontaneously. It is crucial to repair these defects during the early stages of cartilage degeneration to prevent the progression of OA. Currently used clinical interventions however have been unable to completely restore/regenerate damaged articular cartilage to its native state. This has led to considerable interest in the development of effecti
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Hurley, Jennifer R. "Tissue engineering strategies for cardiac regeneration." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1320681698.

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47

Haji, Ruslan Khairunnisa Nabilah. "Protein hydrogels as tissue engineering scaffolds." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/protein-hydrogels-as-tissue-engineering-scaffolds(45ff4e72-49ea-46df-9e7b-b9113576c096).html.

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Hydrogels aim to mimic the natural living environment by entrapping large amount of water or biological fluids in their polymeric network. There has been growing interest in the development of peptide and protein hydrogels, due to their improved biocompatibility, biodegradability and biological properties in comparison to purely synthetic polymer hydrogels. Under the appropriate conditions, biomacromolecular protein hydrogels can self-assemble into ordered meso- to macroscopic supramolecules with better resulting networks that promote tissue development. The work presented here mainly focuses
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48

Dreesmann, Lars. "Zelluläre Mechanismen beim Neuro Tissue-Engineering." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:100-opus-2100.

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49

Junker, Johan P. E. "Human dermal fibroblasts in tissue engineering /." Linköping : Department of Clinical and Experimental Medicine, Linköping University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19716.

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50

McDevitt, Todd C. "Spatially controlled engineering of myocardial tissue /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/8090.

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