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Journal articles on the topic 'Tissue hypo perfusion'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Reitmeir, Raluca, Jens Eyding, Markus F. Oertel, et al. "Is ultrasound perfusion imaging capable of detecting mismatch? A proof-of-concept study in acute stroke patients." Journal of Cerebral Blood Flow & Metabolism 37, no. 4 (2016): 1517–26. http://dx.doi.org/10.1177/0271678x16657574.

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In this study, we compared contrast-enhanced ultrasound perfusion imaging with magnetic resonance perfusion-weighted imaging or perfusion computed tomography for detecting normo-, hypo-, and nonperfused brain areas in acute middle cerebral artery stroke. We performed high mechanical index contrast-enhanced ultrasound perfusion imaging in 30 patients. Time-to-peak intensity of 10 ischemic regions of interests was compared to four standardized nonischemic regions of interests of the same patient. A time-to-peak >3 s (ultrasound perfusion imaging) or >4 s (perfusion computed tomography and

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Eyding, Jens, Christos Krogias, Martin Schöllhammer, et al. "Contrast-Enhanced Ultrasonic Parametric Perfusion Imaging Detects Dysfunctional Tissue at Risk in Acute MCA Stroke." Journal of Cerebral Blood Flow & Metabolism 26, no. 4 (2005): 576–82. http://dx.doi.org/10.1038/sj.jcbfm.9600216.

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Ultrasonic perfusion imaging predicts size and localization of acute stroke. It is unclear whether irreversibly damaged tissue can be differentiated from tissue at risk. Thirty-four patients (ischemic stroke <12 h) were included (Phase Inversion Harmonic Perfusion Imaging; bolus kinetic; fitted model function). Three patterns of perfusion were defined in 14 prespecified regions of interest (ROI): ‘normal', ‘hypoperfusion', and ‘no perfusion'. Clinical status was assessed using the National Institutes of Health Stroke Scale (NIHSS) (at baseline and at days 2 to 4). Cranial Computed Tomograph

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Skopalík, Josef, Jiří Sekora, Martin Pešl, et al. "UPGRADE OF THE LANGENDORFF APPARATUS USING THE INFRARED THERMO-CONTROL SYSTEM AND AN INTELLIGENT HEATER." Lékař a technika - Clinician and Technology 50, no. 4 (2020): 137–41. http://dx.doi.org/10.14311/ctj.2020.4.03.

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Biological experiments involving isolated organs and tissues demand precise temperature monitoring and regulation. An automatic temperature control system was proposed and optimised on real isolated swine hearts and the prototype is described in this work. The traditional Langendorff apparatus consists of a heart holder, a reservoir of perfusion solution flowing to aortic cannula and a heating bath allowing passive heat transfer to the reservoir of perfusion solution. The commercial infrared camera FLIR T62101 was added to this basic set-up and used for very precise monitoring of the temperatu

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International, Journal of Medical Science and Innovative Research (IJMSIR). "Association of serum lactate and morbidity in patients undergoing major abdominal surgery- A Literature Review." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 3 (2024): 22–29. https://doi.org/10.5281/zenodo.15402734.

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<strong>Abstract</strong> Major abdominal surgery carries a significant risk of postoperative morbidity and prolonged hospital stays. Timely identification of complications and appropriate management strategies are crucial for optimizing patient outcomes. Serum lactate levels have emerged as a potential biomarker for assessing tissue hypo perfusion and predicting adverse outcomes in various clinical settings. This research paper aims to review the existing literature on the utility of serum lactate as an indicator for morbidity and hospital stay in patients undergoing major abdominal surgery.

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Costa, Filipe Gonçalves, Naser Hakimi, and Frank Van Bel. "Neuroprotection of the Perinatal Brain by Early Information of Cerebral Oxygenation and Perfusion Patterns." International Journal of Molecular Sciences 22, no. 10 (2021): 5389. http://dx.doi.org/10.3390/ijms22105389.

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Abnormal patterns of cerebral perfusion/oxygenation are associated with neuronal damage. In preterm neonates, hypoxemia, hypo-/hypercapnia and lack of cerebral autoregulation are related to peri-intraventricular hemorrhages and white matter injury. Reperfusion damage after perinatal hypoxic ischemia in term neonates seems related with cerebral hyperoxygenation. Since biological tissue is transparent for near infrared (NIR) light, NIR-spectroscopy (NIRS) is a noninvasive bedside tool to monitor brain oxygenation and perfusion. This review focuses on early assessment and guiding abnormal cerebra

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Smith, M. L., R. von Hanwehr, and B. K. Siesjö. "Changes in Extra- and Intracellular pH in the Brain during and following Ischemia in Hyperglycemic and in Moderately Hypoglycemic Rats." Journal of Cerebral Blood Flow & Metabolism 6, no. 5 (1986): 574–83. http://dx.doi.org/10.1038/jcbfm.1986.104.

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Incomplete forebrain ischemia of 15-min duration was induced in rats made hyperglycemic or moderately hypoglycemic prior to ischemia. Tissue CO2 tension, CO2 content, labile tissue metabolites, and extracellular pH (pHe) were measured, and intracellular pH (pHi) was derived by calculation on the assumption that cerebral intracellular fluids can be lumped into one space. In hypoglycemic animals, mean tissue lactate content increased from 2 to 10 μmol g−1. Tissue CO2 content was virtually unchanged and the CO2 tension increased from ∼50 to ∼145 mm Hg. In hyperglycemic animals, tissue lactate con

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Eyding, Jens, Christian Fung, Wolf-Dirk Niesen, and Christos Krogias. "Twenty Years of Cerebral Ultrasound Perfusion Imaging—Is the Best yet to Come?" Journal of Clinical Medicine 9, no. 3 (2020): 816. http://dx.doi.org/10.3390/jcm9030816.

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Over the past 20 years, ultrasonic cerebral perfusion imaging (UPI) has been introduced and validated applying different data acquisition and processing approaches. Clinical data were collected mainly in acute stroke patients. Some efforts were undertaken in order to compare different technical settings and validate results to gold standard perfusion imaging. This review illustrates the evolution of the method, explicating different technical aspects and milestones achieved over time. Up to date, advancements of ultrasound technology as well as data processing approaches enable semi-quantitati

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Duelli, Roman, and Wolfgang Kuschinsky. "Changes in Brain Capillary Diameter during Hypocapnia and Hypercapnia." Journal of Cerebral Blood Flow & Metabolism 13, no. 6 (1993): 1025–28. http://dx.doi.org/10.1038/jcbfm.1993.129.

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Since changes in the surface area of capillaries may be relevant to capillary exchange, the distensibility of brain capillaries was investigated. Brain capillary diameters were measured after perfusion fixation of brain tissue at a constant perfusion pressure during hypo- or hypercapnia. Sections were embedded, stained, and analyzed by light microscopy. The results showed significant differences in mean capillary diameter between the hypocapnic and the hypercapnic group. In the eight brain structures analyzed, capillary diameters were always larger in the hypercapnic group. Mean capillary diam

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9

Thompson, Cynthia K., Matthew Walenski, YuFen Chen, et al. "Intrahemispheric Perfusion in Chronic Stroke-Induced Aphasia." Neural Plasticity 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/2361691.

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Stroke-induced alterations in cerebral blood flow (perfusion) may contribute to functional language impairments and recovery in chronic aphasia. Using MRI, we examined perfusion in the right and left hemispheres of 35 aphasic and 16 healthy control participants. Across 76 regions (38 per hemisphere), no significant between-subjects differences were found in the left, whereas blood flow in the right was increased in the aphasic compared to the control participants. Region-of-interest (ROI) analyses showed a varied pattern of hypo- and hyperperfused regions across hemispheres in the aphasic part

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Frustaci, Andrea, Rosario Cianci, Romina Verardo, Bruna Cerbelli, Maria Cecilia D’Asdia, and Alessandro De Luca. "Novel Genetic Microvascular Dysplasia Causing Hypoperfusion of Cardiac, Renal, and Cerebral Circulation." Journal of Clinical Medicine 12, no. 22 (2023): 7150. http://dx.doi.org/10.3390/jcm12227150.

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Background: Microvascular disorders represent an uncommon site of tissue hypo-perfusion and damage. Various genetic and acquired causes can be involved. A 65-year-old man was admitted because of refractory angina, which he had had since the age of 30 years, micro-hematuria, and recurrent transitory ischemic attacks from the age of 64. Methods: Hematochemical studies, ECG, Holter monitoring, 2D-echo, cardiac magnetic resonance (CMR), CTA of cerebral vessels, endomyocardial coronary angiography, and kidney biopsy processes were undertaken. Gene mutation analysis was conducted using next-generati

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11

Fan, Audrey P., Ahmed A. Khalil, Jochen B. Fiebach, et al. "Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke." Journal of Cerebral Blood Flow & Metabolism 40, no. 3 (2019): 539–51. http://dx.doi.org/10.1177/0271678x19827944.

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Recent clinical trials of new revascularization therapies in acute ischemic stroke have highlighted the importance of physiological imaging to identify optimal treatments for patients. Oxygen extraction fraction (OEF) is a hallmark of at-risk tissue in stroke, and can be quantified from the susceptibility effect of deoxyhemoglobin molecules in venous blood on MRI phase scans. We measured OEF within cerebral veins using advanced quantitative susceptibility mapping (QSM) MRI reconstructions in 20 acute stroke patients. Absolute OEF was elevated in the affected (29.3 ± 3.4%) versus the contralate

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Hiranandani, Nitisha, Kenneth D. Varian, Michelle M. Monasky, and Paul M. L. Janssen. "Frequency-dependent contractile response of isolated cardiac trabeculae under hypo-, normo-, and hyperthermic conditions." Journal of Applied Physiology 100, no. 5 (2006): 1727–32. http://dx.doi.org/10.1152/japplphysiol.01244.2005.

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The body is from time to time exposed to nonnormothermic conditions; both hypo- and hyperthermia can occur as a result of external (environment) or internal (pathogens, allergens) stressors. To preserve life under hypo- and hyperthermic conditions, adequate perfusion of vital organs is mandated. Although cardiac output regulation under hyperthermic conditions has been studied, the mechanical response of basic contractile function of the myocardium itself is incompletely understood. Accordingly, we set out to test mechanical output of isolated myocardium under hyperthermic conditions and to com

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Zakharova, A. V. "Correlation of MR pulmonary perfusion in patients with COVID-19 with quantitative assessment of acute phase CT images." Diagnostic radiology and radiotherapy 14, no. 3 (2023): 61–66. http://dx.doi.org/10.22328/2079-5343-2023-14-3-61-66.

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INTRODUCTION: In the last decade, there has been an increased interest in new diagnostic techniques for assessing quantitative values in radiology. In particular, accurate quantitative values may be useful to assess anatomical or physiological changes in the lungs in patients with previously treated COVID-19 infection.OBJECTIVE: To test a quantitative semi-automated algorithm for CT imaging in patients with confirmed COVID-19 infection and to compare the results to MR lung perfusion after coronavirus infection.MATERIALS AND METHODS: The data from 100 chest CT scans of patients with COVID-19 we

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Velickovic, Jelena, Guillaume Thiery, Dejan Velickovic, et al. "Serum lactate: Role in the assessment of microhemodynamics in critically ill patients." Acta chirurgica Iugoslavica 63, no. 2 (2016): 41–47. http://dx.doi.org/10.2298/aci1602041v.

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Many critically ill patients with stabilized hemodynamics die with signs of multiorgan failure. One of the reasons is the derangement of microcirculation and tissue perfusion. It has been shown that microcirculatory distress left uncorrected for 24 hours is single independent predictor of mortality in sepsis. Serum lactate is the only indicator of microcirculatory changes that is monitored routinely in all critically ill patients. It has been widely believed that hyperlactatemia in sepsis is marker of tissue hypoxia and indicates the existence of oxygen debt resulting from tissue hypoperfusion

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15

Kerleroux, Basile, Kevin Janot, Cyril Dargazanli, et al. "Perfusion Imaging to Select Patients with Large Ischemic Core for Mechanical Thrombectomy." Journal of Stroke 22, no. 2 (2020): 225–33. http://dx.doi.org/10.5853/jos.2019.02908.

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Background and Purpose Patients with acute ischemic stroke, proximal vessel occlusion and a large ischemic core at presentation are commonly not considered for mechanical thrombectomy (MT). We tested the hypothesis that in patients with baseline large infarct cores, identification of remaining penumbral tissue using perfusion imaging would translate to better outcomes after MT.<br/>Methods This was a multicenter, retrospective, core lab adjudicated, cohort study of adult patients with proximal vessel occlusion, a large ischemic core volume (diffusion weighted imaging volume ≥70 mL), with

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16

Marco, Aurora De, Gerardo Cazzato, Rosalba Maggialetti, et al. "Placental ACE2 Expression: A Possible Pathogenetic Mechanism for Infantile Hemangiomas." Dermatopathology 11, no. 3 (2024): 192–99. http://dx.doi.org/10.3390/dermatopathology11030020.

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ACE2 is a mono-carboxypeptidase with remarkable vasculo-protective properties, and its expression in the human placenta plays a central role in blood pressure homeostasis and fetal perfusion. Therefore, an alteration in the placental expression of ACE2 could be responsible for reduced placental perfusion and infantile hemangioma (IH) development. Study placentae were collected from patients affected by IHs who were referred to our Dermatology Clinic from 2016 to 2022, while control placentae were randomly collected while matching cases for gestational age. Immunohistochemical investigations we

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Tyan, C., S. Armstrong, R. Khan, et al. "407 Tissue injury and stress hypo-perfusion in hypertrophic cardiomyopathy: Spatial correlation of T2-wieghted imaging, first-pass stress perfusion imaging and delayed enhancement imaging using cardiovascular magnetic resonance." Canadian Journal of Cardiology 27, no. 5 (2011): S209. http://dx.doi.org/10.1016/j.cjca.2011.07.344.

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18

Emery, Michael J., Randy L. Eveland, Seong S. Kim, Jacob Hildebrandt, and Erik R. Swenson. "CO2 relaxes parenchyma in the liquid-filled rat lung." Journal of Applied Physiology 103, no. 2 (2007): 710–16. http://dx.doi.org/10.1152/japplphysiol.00128.2006.

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CO2 regulation of lung compliance is currently explained by pH- and CO2-dependent changes in alveolar surface forces and bronchomotor tone. We hypothesized that in addition to, but independently of, those mechanisms, the parenchyma tissue responds to hypercapnia and hypocapnia by relaxing and contracting, respectively, thereby improving local matching of ventilation (V̇a) to perfusion (Q̇). Twenty adult rats were slowly ventilated with modified Krebs solution (rate = 3 min−1, 37°C, open chest) to produce unperfused living lung preparations free of intra-airway surface forces. The solution was

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Souza, Thaís Mello de, and Marcelo Gomes de Carvalho. "Assistência de enfermagem no choque cardiogênico pós infarto agudo do miocárdio." Revista Recien - Revista Científica de Enfermagem 1, no. 2 (2011): 17. http://dx.doi.org/10.24276/rrecien2177-157x.2011.1.2.17-22.

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Infarto agudo do miocárdio é um foco de necrose resultante da perfusão inadequada do tecido. No Brasil, admite-se uma incidência em torno de 300.000 infartos por ano. O choque cardiogênico é uma situação de hipoperfusão tecidual sistêmica devido à incapacidade do músculo cardíaco fornecer débito adequado às necessidades do organismo. Estudo de revisão bibliográfica com objetivo revisar e avaliar acerca da assistência de enfermagem no choque cardiogênico pós infarto agudo do miocárdio. O rastreamento foi feito nas bases de LILACS e SciELO. A Sociedade Brasileira de Cardiologia publica, desde 19

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Dr., Mohanad Abdulqader Atta, and Ali Dheyaa Mahdi Khafaja Dr. "Hemodynamic Change in Patients with Severe Type of Preeclampsia under Spinal Anesthesia for Cesarean section Labor." Academic Journal of Medical Sciences 9, no. 3 (2023): 174–86. https://doi.org/10.5281/zenodo.8286960.

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<strong>Abstract</strong> <strong>Background</strong>: A preeclampsia with severity (SP) is a multi-systemic disease characterized by vasospasm, hypo perfusion with multi-organ and endothelial damage. <strong>Objective</strong>: to describe the changes in SvcO2 during Spinal anesthesia of SP patients undergoing cesarean section. <strong>Patients and methods</strong>: A prospective study was conducted of a convenience sample that included 25 pregnant patients with SP subjected to Cs under spinal anesthesia.  <strong>Results</strong>: A positive, weak significant linear association was dete

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He, Yingke, John Ong, and Sharon Ong. "Refractory Lactic Acidosis and an Approach to Its Management - A Case Report." Journal of Critical Care Medicine 5, no. 2 (2019): 60–65. http://dx.doi.org/10.2478/jccm-2019-0010.

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AbstractBackgroundLactic acidosis (LA) is a complication of diseases commonly seen in intensive care patients which carries an increased risk of mortality. It is classified by its pathophysiology; Type A results from tissue hypo-perfusion and hypoxia, and Type B results from abnormal metabolic activity in the absence of hypoxia. Reports of the co-occurrence of both types have been rarely reported in the literature relating to intensive care patients. This case report describes the challenging management of a patient diagnosed with both Type A and Type B LA.Case presentationA 55-year-old female

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Radzina, Maija, Madara Ratniece, Davis Simanis Putrins, Laura Saule, and Vito Cantisani. "Performance of Contrast-Enhanced Ultrasound in Thyroid Nodules: Review of Current State and Future Perspectives." Cancers 13, no. 21 (2021): 5469. http://dx.doi.org/10.3390/cancers13215469.

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Ultrasound has been established as a baseline imaging technique for thyroid nodules. The main advantage of adding CEUS is the ability to assess the sequence and intensity of vascular perfusion and hemodynamics in the thyroid nodule, thus providing real-time characterization of nodule features, considered a valuable new approach in the determination of benign vs. malignant nodules. Original studies, reviews and six meta-analyses were included in this article. A total of 624 studies were retrieved, and 107 were included in the study. As recognized for thyroid nodule malignancy risk stratificatio

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Michel, Ferreira Machado, Cotchi Simbo Muela Henrique, Aparecida Costa-Hong Valeria, et al. "Antihypertensives and Cerebral Autoregulation: Historical Perspectives and Pathophysiological Insights." Research & Reviews: Journal of Medical and Health Sciences 12, no. 1 (2023): 7. https://doi.org/10.5281/zenodo.13374883.

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Background: Cerebral Autoregulation (CA) consists of a complex mechanism characterized by the ability of the cerebral microcirculation to contract and dilate in response to variations in Blood Pressure (BP), aiming to keep Cerebral Blood Flow (CBF) constant. Systemic arterial hypertension lead to an increase in cerebrovascular resistance, which can negatively influence this vasomotor response, shifting the CA curve to the right. Thus, a slight hypotension could compromise the CBF and cause damage to brain tissue. Objective: From a brief historical perspective, the physiological mechanisms by w

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Febrinasari, Ratih Puspita, Kenneth Tan, Astrida Fesky Febrianty, and Yusuf Ari Mashuri. "Effectiveness of Norepinephrine-Vasopressin Combination in Reducing Mortality in Septic Shock Patients: A Scoping Review." JPSCR: Journal of Pharmaceutical Science and Clinical Research 7, no. 1 (2022): 48. http://dx.doi.org/10.20961/jpscr.v7i1.54626.

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Sepsis and septic shock are the major health problems worldwide, including in Indonesia. Sepsis and septic shock are medical emergencies that require adequate prompt resuscitation to reverse tissue hypo-perfusion, which will prevent patient mortality. The latest international guideline on septic shock treatment recommended norepinephrine as a first-line vasopressor followed by dopamine and dobutamine as an alternative vasopressor. However, the practices still vary. Therefore, a scoping review is required to scope the existing article, summarize scientific evidence, and give a bearing on future

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Greite, Robert, Johanna Störmer, Faikah Gueler, et al. "Different Acute Kidney Injury Patterns after Renal Ischemia Reperfusion Injury and Extracorporeal Membrane Oxygenation in Mice." International Journal of Molecular Sciences 23, no. 19 (2022): 11000. http://dx.doi.org/10.3390/ijms231911000.

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The use of extracorporeal membrane oxygenation (ECMO) is associated with acute kidney injury (AKI) in thoracic organ transplantation. However, multiple other factors contribute to AKI development after these procedures such as renal ischemia-reperfusion injury (IRI) due to hypo-perfusion of the kidney during surgery. In this study, we aimed to explore the kidney injury patterns in mouse models of ECMO and renal IRI. Kidneys of C57BL/6 mice were examined after moderate (35 min) and severe (45 min) unilateral transient renal pedicle clamping and 2 h of veno-venous ECMO. Renal injury markers, neu

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Ghosh, Banna, Muhammed Mahfuzur Rahman, Tanoy Saha, et al. "Drinking Water Sources along the Banks of Buriganga River of Bangladesh are Polluted and Possess Serious Health Risks: A Comprehensive In Vivo Analysis." Journal of Environmental and Public Health 2023 (January 11, 2023): 1–7. http://dx.doi.org/10.1155/2023/3369163.

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Background. The river Buriganga, one of the major dumping zones of industrial wastes in Bangladesh, is responsible for contaminating the drinking water sources along its length. This study aimed to assess the water quality from these sources by monitoring the changes in hematological, biochemical, and histological parameters caused in healthy rats due to their consumption. Methods. Using ethylenediaminetetraacetic acid (EDTA) as an anticoagulant agent, hematological and biochemical analyses of Sprague–Dawley rat models were executed in this study. Following blood sampling, the rats were sacrif

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HN, Vijaya Kumar, and Satish Kumar Madabhavi. "The Use of Intravenous Sodium Bicarbonate in the Treatment of Metabolic Acidosis with Septic Shock." Indian Journal of Anesthesia and Analgesia 9, no. 2 (2022): 81–86. http://dx.doi.org/10.21088/ijaa.2349.8471.9222.11.

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Background: Acute metabolic acidemia, defined as a decrease in blood pH originating from a primary reduction in bicarbonate concentration that is accompanied by an appropriate secondary reduction in PaCO2 and is present for up to a few days, can impair hemodynamics and increase mortality, particularly when severe (arterial blood pH<7.20). Septic shock constitutes an important cause of morbidity and mortality in the critically ill patient. The Surviving Sepsis Campaign recommends against treatment with bicarbonate in patients with lactic acidosis due to hypo perfusion when pH is >7.15 but

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Staehr, Christian, Rajkumar Rajanathan, Dmitry D. Postnov, et al. "Abnormal neurovascular coupling as a cause of excess cerebral vasodilation in familial migraine." Cardiovascular Research 116, no. 12 (2019): 2009–20. http://dx.doi.org/10.1093/cvr/cvz306.

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Abstract Aims Acute migraine attack in familial hemiplegic migraine type 2 (FHM2) patients is characterized by sequential hypo- and hyperperfusion. FHM2 is associated with mutations in the Na, K-ATPase α2 isoform. Heterozygous mice bearing one of these mutations (α2+/G301R mice) were shown to have elevated cerebrovascular tone and, thus, hypoperfusion that might lead to elevated concentrations of local metabolites. We hypothesize that these α2+/G301R mice also have increased cerebrovascular hyperaemic responses to these local metabolites leading to hyperperfusion in the affected part of the br

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Gehrcke, Martielo Ivan, Doughlas Regalin, Vanessa Sasso Padilha, et al. "Arterial, Mixed Venous or Central Venous Hemogasometry and End Tidal CO2 in Dogs under Different Hemodynamic States." Acta Scientiae Veterinariae 45, no. 1 (2017): 8. http://dx.doi.org/10.22456/1679-9216.80007.

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Background: Hemogasometric analysis is used in the interpretation of acid-base balance (ABB) and to access pulmonary ventilation. Already mixed venous oxygen saturation obtained at pulmonary artery correlates with tissue oxygenation. However, both samples can be difficult to access because of the difficulties in arterial and pulmonary catheterization. The aim of this study was to evaluate the feasibility of replacing the arterial and mixed venous bloods, the end tidal pressure of carbon dioxide (EtCO2) and central venous blood in the analysis of pulmonary ventilation, tissue oxygenation and AB

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Cabassi, Aderville, Simonetta Vinci, Fabio Quartieri, Luigi Moschini, Giacomo Bruschi, and Alberico Borghetti. "Impaired Norepinephrine Reuptake in Skeletal Muscle But not in Adipose Tissue After the Development of Hypertension in Rats: an in Vivo Microdialysis Study." Hypertension 36, suppl_1 (2000): 702. http://dx.doi.org/10.1161/hyp.36.suppl_1.702.

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P50 Presynaptic reuptake of norepinephrine (NE) represents the main mechanism to end its effects, once released from sympathetic nerves. This study evaluated the effect of locally administered neuronal uptake inhibitor (desipramine, 10 pmol/min through microdialysis probes) on interstitial NE concentration in the skeletal muscle and subcutaneous adipose tissue from awake and freely moving Wistar-Kyoto (WKY)and spontaneously hypertensive rats (SHR) before and after the development of arterial hypertension. Systolic arterial pressure and plasma NE levels in SHR were similar to WKY at 5 weeks of

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Chernii, V. I. "Infusion therapy in the perioperative period." Infusion & Chemotherapy, no. 3.2 (December 15, 2020): 303–5. http://dx.doi.org/10.32902/2663-0338-2020-3.2-303-305.

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Background. Inadequate volume of perioperative infusion therapy (IT) is one of the predictors of postoperative complications. There are different types of infusion solutions on the pharmaceutical market: albumin, dextrans (Reopoliglukin), polyatomic alcohols (Reosorbilact, Sorbilact), hydroxyethyl starch preparations (Gekodez), modified gelatin (Volutenz), balanced colloid-hyperosmolar solution (Gekoton), etc (all listed solutions are produced by “Yuria-Pharm”). Objective. To describe the main features of perioperative IT. Materials and methods. Analysis of literature sources on th

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Emanueli, Costanza, Alessandra Minasi, Antonella Zacheo, et al. "Human Tissue Kallikrein Gene Transfer Accelerates Spontaneous Angiogenesis Response to Ischemia." Hypertension 36, suppl_1 (2000): 270. http://dx.doi.org/10.1161/hyp.36.suppl_1.270-a.

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P205 Angiogenesis therapy is emerging as a new approach to rescue ischemic tissues not susceptible to benefit from revascularization. We investigated (1) if ischemia modulates the expression of kallikrein-kinin system (KKS) and (2) if potentiation of kinin generation by human tissue kallikrein (HK) gene transfer augments spontaneous angiogenesis and tissue perfusion in a mouse model of ischemia. Hindlimb ischemia, caused by surgical excision of femoral artery, increased capillary density (from 344±15 to 641±54 cap/mm 2 at 21 d after surgery, P<.001) and expression of kinin B 1 receptor gene

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Madeddu, Paolo Roberto, Bonaria Maria Salis, Julie Chao, Lee Chao, and Emanueli Costanza. "Human Tissue Kallikrein Gene Transfer Induces Angiogenesis." Hypertension 36, suppl_1 (2000): 691. http://dx.doi.org/10.1161/hyp.36.suppl_1.691-b.

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74 Angiogenesis therapy is emerging as a new strategy for treatment of vascular disease, not susceptible of revascularization. As kinins are implicated in vascular protection and repair, we hypothesized that targeted potentiation of kinin-nitric oxide (NO) pathway may stimulate neo-vascularization. CD1 mice were IM injected with 3.6x10 8 plaque forming units of adenovirus (Ad) harboring human tissue kallikrein (HK) or β-galactosidase (LacZ) gene under the control of cytomegalovirus enhancer/promoter (CMV). Successful transduction of injected adductor skeletal muscle was documented at mRNA and

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Mohuczy, Dagmara, Hongjiang Chen, Leping Shen, Jawahar L. Mehta, and M. Ian Phillips. "Heart Protection Using a New Approach - Antisense to Angiotensin Converting Enzyme Mrna." Hypertension 36, suppl_1 (2000): 729. http://dx.doi.org/10.1161/hyp.36.suppl_1.729-b.

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P200 Introduction. Angiotensin converting enzyme (ACE), plays a major role in many cardiovascular pathophysiological conditions, such as hypertension, heart failure and myocardial ischemia. Currently used ACE inhibitors have some adverse effects and non-compliance problem. Therefore, our lab has been developing an antisense approach to inhibit the renin-angiotensin system at the gene expression level. The present study had three aims: 1. Design antisense oligodeoxynucleotide (AS-ODN) directed at ACE mRNA 2. Check tissue distribution of AS after iv injection 3. Test AS for heart protection in i

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Sturmberg, Joachim. "HYPE and TENSION in Hypertension. Debating the latest hypertension guidelines." European Journal for Person Centered Healthcare 6, no. 1 (2018): 128. http://dx.doi.org/10.5750/ejpch.v6i1.1509.

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Background: The latest American College of Cardiology/American Heart Association (ACC/AHA) hypertension guidelines promote radical changes to hypertension management - achieving a normal blood pressure (BP) defined as <120 mm Hg systolic and <80 mm Hg diastolic in all. The “rationale” for this re-definition of hypertension remains hotly debated and has been rejected by a variety of bodies.Method: This article approaches the hype and the tensions in hypertension from five different perspectives: (1) Physiology - pressure and flow in a pipe are related to the 4th power of the radius, hence

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Andersen, Frederik Thørholm, Jacob Petersen, Alexander Emil Kaspersen, et al. "Continuous assessment of tissue perfusion using quantitative indocyanine green fluorescence imaging during controlled hypo- and reperfusion." Surgical Endoscopy, July 2, 2025. https://doi.org/10.1007/s00464-025-11905-z.

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Abstract Background Indocyanine green fluorescence imaging (ICG-FI) is a novel tool for continuous assessment of tissue perfusion. However, consensus on the optimal methodology is lacking. It was hypothesized that quantitative ICG-FI parameters based on continuous micro-dosing correlate with corresponding transit time flow measurements in the functional renal end artery. This study aimed to examine the feasibility of continuous, quantitative ICG-FI for detecting perfusion changes (hypoperfusion, reperfusion) in porcine kidneys. Methods Renal perfusion was assessed using continuous, quantitativ

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Li, Shiyi, Jiachen Sun, Jinxiu Yang, et al. "Gelatin methacryloyl (GelMA) loaded with concentrated hypoxic pretreated adipose-derived mesenchymal stem cells(ADSCs) conditioned medium promotes wound healing and vascular regeneration in aged skin." Biomaterials Research 27, no. 1 (2023). http://dx.doi.org/10.1186/s40824-023-00352-3.

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Abstract Background Aging skin is characterized by a disturbed structure and lack of blood supply, which makes it difficult to heal once injured. ADSCs secrete large amounts of cytokines, which promote wound healing and vascular regeneration through paracrine secretion, and the number of cytokines can be elevated by hypoxic pretreating. However, the components of ADSCs are difficult to retain in wounds. Gelatin methacrylate (GelMA) is a photopolymerizable hydrogel synthesized from gelatin and has recently emerged as a potentially attractive material for tissue engineering applications. GelMA l

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Leitão Guerra, Ricardo, Gabriel Castilho Sandoval Barbosa, Cezar Leitão Guerra, et al. "Blue light reflectance imaging in non-perfusion areas detection: insights from multimodal analysis." International Journal of Retina and Vitreous 10, no. 1 (2024). http://dx.doi.org/10.1186/s40942-024-00602-z.

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Abstract Design A retrospective, cross-sectional image analysis using a convenience sample. Subjects Five cases selected based on the availability of comprehensive imaging data. Methods This study involved a retrospective review of images from five cases, focusing on the use of retinal monochromatic blue light reflectance (BLR) imaging to detect non-perfusion areas. Two cases of sickle-cell retinopathy demonstrated peripheral retinal non-perfusion identified through widefield fluorescein angiography. Three other cases—one with branch retinal vein occlusion, one with branch retinal artery occlu

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Samadi, Fardin, Jafar Zamani, Soroor Kalantari, Hanieh Mobarak Salari, and Hamidreza Salighehrad. "Quantification of ASL Perfusion MRI in MCI Patients Using Single-Post Labeling Delay Model-Fitting Approach." Frontiers in Biomedical Technologies, October 30, 2019. http://dx.doi.org/10.18502/fbt.v6i3.1694.

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Purpose: Neuroimaging techniques hold many promises to detect Alzheimer Disease (AD) at early stages before clinical symptoms fully develop, suggesting decreased regional Cerebral Blood Flow (CBF). Perfusion deficiencies are present from very early clinical phases of AD, i.e. Mild Cognitive Impairment (MCI) and persist well into the latest stages, demonstrating a pattern of increased hypo-perfusion with the disease development. Accurate quantification such as quantification model and noise reduction method is necessary to achievement of good results in insufficient Post Labeling Delay (PLD) ti

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Heid, Irina, Marija Trajkovic-Arsic, Fabian Lohöfer, et al. "Functional biomarkers derived from computed tomography and magnetic resonance imaging differentiate PDAC subgroups and reveal gemcitabine-induced hypo-vascularization." European Journal of Nuclear Medicine and Molecular Imaging, September 8, 2022. http://dx.doi.org/10.1007/s00259-022-05930-6.

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Abstract Purpose Pancreatic ductal adenocarcinoma (PDAC) is a molecularly heterogeneous tumor entity with no clinically established imaging biomarkers. We hypothesize that tumor morphology and physiology, including vascularity and perfusion, show variations that can be detected by differences in contrast agent (CA) accumulation measured non-invasively. This work seeks to establish imaging biomarkers for tumor stratification and therapy response monitoring in PDAC, based on this hypothesis. Methods and materials Regional CA accumulation in PDAC was correlated with tumor vascularization, stroma

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Yi-Jie, Qiu, Zhao Guo-Chao, Shi Shuai-Nan, et al. "Application of dynamic contrast enhanced ultrasound in distinguishing focal-type autoimmune pancreatitis from pancreatic ductal adenocarcinoma." Clinical Hemorheology and Microcirculation, February 28, 2022, 1–13. http://dx.doi.org/10.3233/ch-221390.

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OBJECTIVE: To explore the value of dynamic contrast enhanced ultrasound (DCE-US) in preoperative differential diagnosis of focal-type autoimmune pancreatitis (AIP) and pancreatic ductal adenocarcinoma (PDAC). PATIENTS AND METHODS: From May 2016 to March 2020, patients with biopsy and histopathologically confirmed focal-type AIP (n = 9) were retrospectively included. All patients received contrast enhanced ultrasound (CEUS) examinations one week before surgery/biopsy. Dynamic analysis was performed by VueBox® software (Bracco, Italy). Eighteen cases of resection and histopathologically proved P

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Franx, Bart AA, Ivo ACW Tiebosch, Annette van der Toorn, and Rick M. Dijkhuizen. "Chronic hypertension and perfusion deficits conjointly affect disease outcome after tPA treatment in a rodent model of thromboembolic stroke." Journal of Cerebral Blood Flow & Metabolism, January 22, 2025. https://doi.org/10.1177/0271678x241310732.

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Futile recanalization hampers prognoses for ischemic stroke patients despite successful recanalization therapy. Allegedly, hypertension and reperfusion deficits contribute, but a better understanding is needed of how they interact and mediate disease outcome. We reassessed data from spontaneously hypertensive and normotensive Wistar-Kyoto rats (male, n = 6–7/group) that were subjected to two-hour embolic middle cerebral artery occlusion and thrombolysis in preclinical trials. Serial MRI allowed lesion monitoring and parcellation of regions-of-interest that represented infarcted (core) or recov

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Sliwicka, O., I. Sechopoulos, and J. Habets. "Objective evaluation of improved image quality with application of novel noise reduction filter in dynamic myocardial CT perfusion." European Heart Journal - Cardiovascular Imaging 22, Supplement_1 (2021). http://dx.doi.org/10.1093/ehjci/jeaa356.244.

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Abstract Funding Acknowledgements Type of funding sources: None. Background Dynamic myocardial CT perfusion (CTP) is a non-invasive imaging technique able to depict cardiac ischemia. It is expected that the application of a new dynamic perfusion image noise reducing filter, the similarity filter (4DSF) would improve the image quality of CTP, resulting in clear visualization of perfusion deficits and hypo-perfused tissue and allowing for a substantial reduction in the radiation dose in dynamic myocardial CTP. Purpose To evaluate image quality before and after the application of a novel noise re

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Christensen, Soren, Bill O'Brien, Bijoy Menon, et al. "Abstract 54: Mapping of Cerebral Vascular Territories Using Whole Brain Perfusion CT Imaging: A New Method." Stroke 43, suppl_1 (2012). http://dx.doi.org/10.1161/str.43.suppl_1.a54.

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Introduction: The nature and endurance of the collateral blood supply in acute stroke is speculated to play a key role in tissue survival, yet research in this area is limited by the lack of appropriate imaging modalities to characterize and quantify collateral flow. We present the first results of a novel post-processing technique that can label and quantify the extent of the major vascular territories, including the predominant source of collateral supply into the hypo-perfused regions, using a 320 slice whole brain perfusion CT acquisition. Hypothesis: We hypothesized that the perfusion ter

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Bijvoet, G. P., H. M. J. M. Nies, R. J. Holtackers, et al. "Tissue characterisation of acute ablation lesions in the right atrium during CMR-guided atrial flutter ablation." European Heart Journal - Cardiovascular Imaging 24, Supplement_1 (2023). http://dx.doi.org/10.1093/ehjci/jead119.415.

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Abstract Funding Acknowledgements Type of funding sources: None. Background Cardiac magnetic resonance (CMR)-guided ablation therapy offers a unique opportunity and incentive to investigate acute ablation lesions. Until present, human studies only used T2-weighted imaging (T2WI) and late gadolinium enhancement (LGE) to assess acute ablation lesions. Purpose To investigate the tissue characteristics of acute ablation lesions during CMR-guided atrial flutter ablation, by combining T2WI and LGE with first-pass perfusion and T1 mapping. Methods Thirteen patients with typical isthmus-dependent atri

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Allam, Aya Elsayed Ibrahim, Alaa Mohamed Reda, Mai Abd El Raouf Saed Ahmed Eissa, and Rania Essam Eldein Mohamed Ali Salem. "Usefulness of combined pseudo-continuous arterial spin labelling and spectroscopic analysis in schizophrenic Egyptian population sample." Egyptian Journal of Radiology and Nuclear Medicine 55, no. 1 (2024). http://dx.doi.org/10.1186/s43055-024-01319-7.

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Abstract Background Schizophrenia is a prevalent psychiatric disorder that affects 1% of the global population. Schizophrenia frequently begins in late adolescence or early adulthood, causing significant educational, social, and economic costs for people and society. Functional neuroimaging research on schizophrenia physiopathology has been beneficial. Arterial spin labelling (ASL) is one of functional magnetic resonance imaging (fMRI) technologies that assess brain function without radiation. ASL uses magnetic resonance (MR) imaging to quantify tissue-level brain perfusion non-invasively. Art

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Gündüz, Ahmet Kaan, and Diğdem Tetik. "Follow-up of retinoblastoma using RetCam fluorescein angiography and correlation with clinical findings." European Journal of Ophthalmology, March 20, 2023, 112067212311636. http://dx.doi.org/10.1177/11206721231163619.

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Purpose To report RetCam fluorescein angiographic (FA) changes and correlation with clinical findings in the follow-up of retinoblastoma (RB) after frontline intravenous chemotherapy and other treatments. Methods Patients having RB who underwent post-treatment RetCam fundus photography and FA under general anesthesia between February 2020 and February 2022 were retrospectively analyzed. Results 78 eyes of 70 patients with RB were included. In 55 (70.5%) eyes with type 1, 2 or 3 regression patterns, the main tumor started to show hyperfluorescence in arterial phase in 24 eyes (43.6%), in early

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Amarelle, Luciano, Lucía Quintela, Javier Hurtado, and Leonel Malacrida. "Hyperoxia and Lungs: What We Have Learned From Animal Models." Frontiers in Medicine 8 (March 9, 2021). http://dx.doi.org/10.3389/fmed.2021.606678.

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Although oxygen (O2) is essential for aerobic life, it can also be an important source of cellular damage. Supra-physiological levels of O2 determine toxicity due to exacerbated reactive oxygen species (ROS) production, impairing the homeostatic balance of several cellular processes. Furthermore, injured cells activate inflammation cascades, amplifying the tissue damage. The lung is the first (but not the only) organ affected by this condition. Critically ill patients are often exposed to several insults, such as mechanical ventilation, infections, hypo-perfusion, systemic inflammation, and dr

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Khan, Romeesa, Gary Guzman, Michael E. Maniskas, Tan ChunFeng, Jun Li, and Louise D. McCullough. "Abstract 105: Sex Differences In The Response To Global Cerebral Hypo-Perfusion In A Mouse Model Of Cerebral Amyloid Angiopathy." Stroke 54, Suppl_1 (2023). http://dx.doi.org/10.1161/str.54.suppl_1.105.

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Cerebral amyloid angiopathy (CAA) is a disease of small and medium-sized vessels, characterized by amyloid deposition. The incidence of CAA increases with age and evidence reveals worsened cognition in females compared to males. Cerebral hypoperfusion, or a decrease in cerebral blood flow (CBF), changes the integrity of the blood brain barrier and contributes to microhemorrhages, cerebral atrophy, and white matter loss. However, the link between vascular amyloid deposition and hypoperfusion remains understudied. We induced global cerebral hypoperfusion with bilateral carotid artery stenosis (B

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Wang, Manzhi, Tao Sun, Liang Dong, Shengshi Huang, and Ju Liu. "Symmetrical peripheral gangrene: potential mechanisms and therapeutic approaches in severe COVID-19." Frontiers in Cardiovascular Medicine 10 (November 29, 2023). http://dx.doi.org/10.3389/fcvm.2023.1280625.

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Symmetrical peripheral gangrene is a rare condition that is characterized by ischemic damage and tissue death (gangrene) in the extremities. Recent reports have shed light on SPG in patients with severe COVID-19. This condition presents with symmetrical cyanosis of the extremities and common COVID-19 symptoms and what the most frightening is within a few days, cutaneous necrosis occurred and patients died. Skin biopsy results have shown the presence of microthrombi in small vessels. The formation of SPG in COVID-19 patients results from immunothrombosis, endothelial dysfunction, and procoagula

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