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Relevant bibliographies by topics / Tissue-specific knockout

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Academic literature on the topic 'Tissue-specific knockout'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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Journal articles on the topic "Tissue-specific knockout"

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Burns, Kathleen H., Julio E. Agno, Piotr Sicinski та Martin M. Matzuk. "Cyclin D2 and p27 Are Tissue-Specific Regulators of Tumorigenesis in Inhibin α Knockout Mice". Molecular Endocrinology 17, № 10 (2003): 2053–69. http://dx.doi.org/10.1210/me.2003-0038.

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Abstract Inhibins are heterodimeric (α:βA and α:βB) endocrine, paracrine, and autocrine factors of the TGFβ superfamily that are produced predominantly by ovarian granulosa cells in females and testicular Sertoli cells in males. Control of granulosa and Sertoli cell proliferation is lost in the inhibin α (Inhα) knockout mouse model, leading to gonadotropin-dependent gonadal tumors of the granulosa/Sertoli cell lineage in both females and males. Castrate Inhα knockout mice develop sex steroidogenic tumors of the adrenal cortex. Physiological control of granulosa/Sertoli cell cycle progression d

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Mirandola, Sandra R., Alexei P. Kudin, and Wolfram S. Kunz. "Tissue specific effects of MnSOD knockout in mice." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797 (July 2010): 61. http://dx.doi.org/10.1016/j.bbabio.2010.04.199.

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Bagnall, Dr Alan, David Webb, and Dr Yuri Kotelevtsev. "Tissue Specific Knockout of the Mouse Endothelin B receptor." Clinical Science 103, s47 (2002): 15P. http://dx.doi.org/10.1042/cs103015p.

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de Lange, Willem J., Carmen M. Halabi, Andreas M. Beyer, and Curt D. Sigmund. "Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles." Physiological Genomics 35, no. 1 (2008): 1–4. http://dx.doi.org/10.1152/physiolgenomics.90284.2008.

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Tissue-specific knockouts generated through Cre-loxP recombination have become an important tool to manipulate the mouse genome. Normally, two successive rounds of breeding are performed to generate mice carrying two floxed target-gene alleles and a transgene expressing Cre-recombinase tissue-specifically. We show herein that two promoters commonly used to generate endothelium-specific ( Tie2) and smooth muscle-specific [smooth muscle myosin heavy chain ( Smmhc)] knockout mice exhibit activity in the female and male germ lines, respectively. This can result in the inheritance of a null allele

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Wei, C., A. Rashid, C. Amos, M. Gannon, and M. L. Frazier. "LKB1 GENE TISSUE SPECIFIC KNOCKOUT MOUSE MODEL FOR PANCREATIC CANCER." Pancreas 31, no. 4 (2005): 478. http://dx.doi.org/10.1097/01.mpa.0000193795.44003.bb.

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Kos, Claudine H. "Cre/loxP System for Generating Tissue-specific Knockout Mouse Models." Nutrition Reviews 62, no. 6 (2004): 243–46. http://dx.doi.org/10.1301/nr2004.jun243-246.

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Sakai, Satoshi. "Development of Tissue- and Time-specific Gene Knockout in Mice." Journal of Cardiac Failure 13, no. 6 (2007): S10. http://dx.doi.org/10.1016/j.cardfail.2007.06.042.

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Zhang, Cong, Kalyne Bertolin, Raj Duggavathi, and Bruce D. Murphy. "Orphan Nuclear Receptors in Reproduction: Lessons from Tissue-Specific Knockout Mice." Biology of Reproduction 85, Suppl_1 (2011): 161. http://dx.doi.org/10.1093/biolreprod/85.s1.161.

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Rindler, Tara N., Valerie M. Lasko, Michelle L. Nieman, Motoi Okada, John N. Lorenz та Jerry B. Lingrel. "Knockout of the Na,K-ATPase α2-isoform in cardiac myocytes delays pressure overload-induced cardiac dysfunction". American Journal of Physiology-Heart and Circulatory Physiology 304, № 8 (2013): H1147—H1158. http://dx.doi.org/10.1152/ajpheart.00594.2012.

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The α2-isoform of the Na,K-ATPase (α2) is the minor isoform of the Na,K-ATPase expressed in the cardiovascular system and is thought to play a critical role in the regulation of cardiovascular hemodynamics. However, the organ system/cell type expressing α2 that is required for this regulation has not been fully defined. The present study uses a heart-specific knockout of α2 to further define the tissue-specific role of α2 in the regulation of cardiovascular hemodynamics. To accomplish this, we developed a mouse model using the Cre/loxP system to generate a tissue-specific knockout of α2 in the

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Yamada, Atsushi, Atsu Aiba, and Ryutaro Kamijo. "Rho family small G proteins: Lessons from tissue-specific gene knockout studies." Journal of Oral Biosciences 56, no. 1 (2014): 23–29. http://dx.doi.org/10.1016/j.job.2013.10.003.

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Dissertations / Theses on the topic "Tissue-specific knockout"

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Sigman, Meredith Jane. "Developing Methods to Validate Tissue Specific Growth Hormone Receptor Knockout Mouse Models." Ohio University Honors Tutorial College / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1391265316.

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Zhao, Haotian. "Exploring the role of fibroblast growth factor (FGF) signaling in mouse lens fiber differentiation through tissue-specific disruption of FGF receptor gene family." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1072722841.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xii, 203 p.; also includes graphics (some col.) Includes bibliographical references (p. 179-203). Available online via OhioLINK's ETD Center

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Usoskin, Dmitry. "Role of Bone Morphogenetic Proteins for Catecholaminergic Neurons in Vivo : Use of the Tyrosine Hydroxylase Locus for Cell-Specific inactivation of Signal Transduction." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4258.

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Zhang, Han. "An Optimized Polymerase Chain Reaction to Verify the Presence or Absence of the Growth Hormone Receptor Gene." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1366378898.

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Pohlers, Michael. "Generierung und Analyse EMA/E2F-6-defizienter Mäuse." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2005. http://dx.doi.org/10.18452/15393.

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The present study focuses on the biological functions of the transcription factor EMA/E2F-6, a member of the E2F-family of transcription factors that play an import role in cell cycle progression, differentiation and apoptosis. EMA/E2F-6 functions as a transcriptional repressor by recruiting a large protein complex, that includes polycomb group proteins, to specific target genes in order to silence their expression. To identify the biological functions of EMA/E2F-6 mice lacking this factor were developed and subsequently analysed. EMA/E2F6-/- mice are born with the expected frequency, are fer

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Tung, Yu-Hui, and 童愈惠. "Functional Study of IKKb in Adrenal and Testicular Steroidogenesis by Tissue-Specific Knockout Technique." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/60759211492829777959.

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Backman, Stéphanie Ann. "Characterization of physiological Pten function in the brain, skin and prostate using tissue-specific knockout mice." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=94724&T=F.

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Lo, Hung, and 羅鴻. "Study on roles of Cdk12 in basal and luminar type epithelial cells by tissue specific conditional knockout mice." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/69705212382472349312.

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碩士<br>國立陽明大學<br>生命科學系暨基因體科學研究所<br>103<br>Cyclin dependent kinase 12, CDK12, is involved in genomic stability, homologous recombination, transcription, alternative splicing, translation, self-renewal and axonal elongation. Recent studies showed that dysfunctional CDK12 mutations were found in clinical samples of human ovarian and breast cancers. A high ratio of homozygous mutations of CDK12 was observed in ovarian cancer, which suggests CDK12 is a potential tumor suppressor gene. To study whether CDK12 deficiency causes cancer formation, two inducible tissue-specific Cre mouse lines, K5-CreERT

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Lin, Ming-Hong, and 林明宏. "Modulatory Effects of Transcriptional Repressor B Lymphocyte-induced Maturation Protein-1 (Blimp-1) on the Development and Function of T Cells in Non-obese Diabetic (NOD) Mice: Using Tissue-specific Transgenic and/or Knockout Approaches." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/56208573516838959982.

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博士<br>國防醫學院<br>醫學科學研究所<br>100<br>Recently, Blimp-1 expands its control over T cells and is associated with susceptibility to colitis in mice with T cell-specific Blimp-1 deficiency. We demonstrate that transgenic expression of Blimp-1 in T cells significantly decreases the incidence of diabetes and myelin oligodendrocyte glycoprotein (MOG)35-55-induced encephalomyelitis in non-obese diabetic (NOD) mice. In contrast, mice lacking Blimp-1 in T cells developed markedly increased Th1 and Th17 cells and exacerbated encephalomyelitis. We show that Blimp-1 orchestrates a T cell-specific modulation of

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Books on the topic "Tissue-specific knockout"

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Backman, Stéphanie Ann. Characterization of physiological Pten function in the brain, skin and prostate using tissue-specific knockout mice. 2004.

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Book chapters on the topic "Tissue-specific knockout"

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Loussouarn, Gildas, Isabelle BarÃ³, and Denis Escande. "Tissue-Specific Transgenic and Knockout Mice." In Ion Channels. Humana Press, 2006. http://dx.doi.org/10.1385/1-59745-095-2:185.

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Lin, Tzu-hua, Shuyuan Yeh, and Chawnshang Chang. "Tissue-Specific Knockout of Androgen Receptor in Mice." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-243-4_16.

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Jiang, Xian-Cheng. "Generation of General and Tissue-Specific Gene Knockout Mouse Models." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-60327-369-5_12.

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Ruzzenente, Benedetta, and Metodi D. Metodiev. "Linear Density Sucrose Gradients to Study Mitoribosomal Biogenesis in Tissue-Specific Knockout Mice." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1008-4_3.

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Aoki, Koji, and Makoto M. Taketo. "Tissue-Specific Transgenic, Conditional Knockout and Knock-In Mice of Genes in the Canonical Wnt Signaling Pathway." In Methods in Molecular Biology. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-249-6_24.

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Trifunovic, Aleksandra, and Nils-Göran Larsson. "Tissue-Specific Knockout Model for Study of Mitochondrial DNA Mutation Disorders." In Methods in Enzymology. Elsevier, 2002. http://dx.doi.org/10.1016/s0076-6879(02)53065-2.

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Hen, Régis, and René Grailhe. "Knockouts: Constitutive, Inducible, or Tissue Specific." In Neurobehavioral Genetics. CRC Press, 1999. http://dx.doi.org/10.1201/9780849333644.ch8.

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Hen, R√©gis, and Ren√© Grailhe. "Knockouts: Constitutive, Inducible, or Tissue Specific." In Neurobehavioral Genetics. CRC Press, 1999. http://dx.doi.org/10.1201/9781420048384.ch8.

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de Bono, Bernard. "The Breadth and Depth of BioMedical Molecular Networks." In Handbook of Research on Systems Biology Applications in Medicine. IGI Global, 2009. http://dx.doi.org/10.4018/978-1-60566-076-9.ch040.

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From a genetic perspective, disease can be interpreted in terms of a variation in molecular sequence or expression (dose) that impairs normal physiological function. To understand thoroughly the knockon effect such pathological changes may have, it is crucial to map out the physiological relationship affected genes maintain with their functional neighbors. The goal of the Reactome project is to build such a network knowledgebase for all human genes. Constructing a map of such extent and scope requires a considerable range of expertise, so this project collaborates with field experts to integrate their pathway knowledge into a single quality-checked human model. This resource dataset is systematically cross-referenced to major molecular and literature databases, and is accessible to the community in a number of well-established formats. As an evolving network systems resource, Reactome is also starting to provide increasingly powerful and robust tools to investigate tissue-specific biology and steer targeted drug design.

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Conference papers on the topic "Tissue-specific knockout"

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Dourte, LeAnn M., Lydia Pathmanathan, Renato V. Iozzo, and Louis J. Soslowsky. "Influence of Decorin and Biglycan on Tensile Viscoelastic Properties in Knockout Mice." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53397.

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Tendons have a complex, viscoelastic mechanical behavior that depends on their composition and structure. Understanding these structure-function relationships may help elucidate important differences in the varying functional behaviors of specific tendons as well as guide targeted treatment modalities and tissue engineered constructs. The tendon extracellular matrix (ECM) can be described as a biocomposite material consisting of collagen fibers surrounded by an extrafibrillar matrix. Many studies have focused on the role of the fibers on the tensile properties of tendon; however, fibers alone

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Hafeez, Bilal B., Louise Meske, Anupama Singh та ін. "Abstract LB-137: Tissue-specific conditional PKCε knockout mice: a model to precisely reveal PKCε functional role in initiation, promotion and progression of cancer". У Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-lb-137.

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