Relevant bibliographies by topics / Tissue-specific peptides

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Tissue-specific peptides'

Author: Grafiati
Published: 28 May 2022
Last updated: 31 July 2025

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Journal articles on the topic "Tissue-specific peptides"

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Ivanov, Vadim T., Oleg N. Yatskin, Olga A. Kalinina, Marina M. Philippova, Andrei A. Karelin, and Elena Yu Blishchenko Shemyakin-Ovchinnikov. "Tissue-specific peptide pools. Generation and function." Pure and Applied Chemistry 72, no. 3 (2000): 355–63. http://dx.doi.org/10.1351/pac200072030355.

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Systematic analysis of several tissue extracts for peptide components followed by bioactivity studies leads to formulation of the concept of "tissue-specific peptide pools". According to that concept the endogenous proteolysis of proteins with well-established functions, such as hemoglobin, actin, and cellular enzymes in tissues leads to formation of the sets (or pools) of bioactive peptides. The sets are tissue-specific on one hand and conservative in a given tissue at normal conditions on the other. The content and the composition of pool components are sensitive both to pathologies linked w
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Nelson, Ryan, and Marc Jenkins. "Implications of T cell receptor cross-reactivity on the CD4+ T cell repertoire (APP3P.111)." Journal of Immunology 194, no. 1_Supplement (2015): 113.12. http://dx.doi.org/10.4049/jimmunol.194.supp.113.12.

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Abstract Naïve CD4+ T cell populations with T cell receptors (TCR) specific for different major histocompatibility complex II (MHCII)-bound foreign peptides vary in size for unknown reasons. Negative selection on self peptides could play a role. We found that MHCII-binding nonamer peptides only had to have the same residues at five positions to be recognized by the same TCR. This degree of TCR cross-reactivity between self and foreign peptides reduced the sizes of foreign peptide-specific T cell populations via clonal deletion. Small foreign p:MHCII-specific populations that underwent a greate
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Fortier, Marie-Hélène, Etienne Caron, Marie-Pierre Hardy, et al. "The MHC I Immunopeptidome Is Moulded by the Transcriptome and Conceals a Tissue-Specific Signature." Blood 110, no. 11 (2007): 1327. http://dx.doi.org/10.1182/blood.v110.11.1327.1327.

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Abstract Background: Cell surface MHC I molecules are associated with self peptides that are collectively referred to as the self MHC I immunopeptidome (sMII). The sMII plays vital roles: it shapes the repertoire of developing thymocytes, transmits survival signals to mature CD8 T cells, amplifies responses against intracellular pathogens, allows immunosurveillance of neoplastic cells, and influences mating preferences in mice. Despite the tremendous importance of the sMII, very little is known on its genesis and molecular composition. Methodology/Principal Findings: We developed a novel high-
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Amir, Avital, Marieke Griffioen, Michel D. G. Kester, et al. "Allo-HLA Reactive CD8 T-Cells May Recognize Tissue Specific Peptides Explaining Tissue Restricted GVHD after HLA Mismatched SCT." Blood 110, no. 11 (2007): 72. http://dx.doi.org/10.1182/blood.v110.11.72.72.

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Abstract HLA disparity between patient and donor increases the risk of GVHD after allogeneic stem cell transplantation (SCT). However, similar to fully HLA matched SCT, the clinical manifestation of GVHD after HLA mismatched SCT is frequently restricted to skin, gut and liver. Based on the frequency of allo-HLA reactive T-cells, which is about a 1000-fold higher than the frequency of minor histocompatibility antigen specific T-cells, the immune response after HLA mismatched SCT is expected to be mediated by allo-HLA reactive T-cells. Theoretically allo-HLA reactive T-cells can exert three diff
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Pruksakorn, S., A. Galbraith, R. A. Houghten, and M. F. Good. "Conserved T and B cell epitopes on the M protein of group A streptococci. Induction of bactericidal antibodies." Journal of Immunology 149, no. 8 (1992): 2729–35. http://dx.doi.org/10.4049/jimmunol.149.8.2729.

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Abstract To identify conserved T and B cell epitopes on the M protein of group A beta-hemolytic streptococci, overlapping synthetic peptides that span the conserved carboxyl-terminal segment of the M-5 protein were constructed and used to immunize a panel of H-2 congenic mice. Proliferative T cell epitopes were identified and, in many cases, mice immunized with these peptides produced high titer antibodies to the same peptides indicating that these proliferative epitopes could also stimulate Th cells. Peptide-specific T cells and antisera were tested for their reactivity with porcine myosin, t
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Papadopoulos, Kyriakos P., Nicole Suciu-Foca, Charles S. Hesdorffer, Sorina Tugulea, Antonella Maffei, and Paul E. Harris. "Naturally Processed Tissue- and Differentiation Stage-Specific Autologous Peptides Bound by HLA Class I and II Molecules of Chronic Myeloid Leukemia Blasts." Blood 90, no. 12 (1997): 4938–46. http://dx.doi.org/10.1182/blood.v90.12.4938.

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Abstract Structural analysis of naturally processed peptides bound to the HLA class I and class II molecules of chronic myeloid leukemia (CML) blast cells was performed to characterize the antigen processing and autoantigen repertoire in this hematopoietic malignancy. Self-peptides derived from the carboxy-terminal end of the breakpoint cluster region (bcr) protein, as well as several differentiation stage- and tissue-specific self-antigens characteristic of early stages of myeloid differentiation, such as c-fes, c-pim, granulocyte-macrophage colony-stimulating factor receptor α chain, protein
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Papadopoulos, Kyriakos P., Nicole Suciu-Foca, Charles S. Hesdorffer, Sorina Tugulea, Antonella Maffei, and Paul E. Harris. "Naturally Processed Tissue- and Differentiation Stage-Specific Autologous Peptides Bound by HLA Class I and II Molecules of Chronic Myeloid Leukemia Blasts." Blood 90, no. 12 (1997): 4938–46. http://dx.doi.org/10.1182/blood.v90.12.4938.4938_4938_4946.

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Structural analysis of naturally processed peptides bound to the HLA class I and class II molecules of chronic myeloid leukemia (CML) blast cells was performed to characterize the antigen processing and autoantigen repertoire in this hematopoietic malignancy. Self-peptides derived from the carboxy-terminal end of the breakpoint cluster region (bcr) protein, as well as several differentiation stage- and tissue-specific self-antigens characteristic of early stages of myeloid differentiation, such as c-fes, c-pim, granulocyte-macrophage colony-stimulating factor receptor α chain, proteinase 3, an
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Pemmari, Toini, Stuart Prince, Niklas Wiss, et al. "Screening of homing and tissue-penetrating peptides by microdialysis and in vivo phage display." Life Science Alliance 8, no. 5 (2025): e202201490. https://doi.org/10.26508/lsa.202201490.

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In vivo phage display is a method used for identification of organ- or disease-specific vascular homing peptides for targeted delivery of pharmaceutics. It is agnostic as to the nature and identity of the target molecules. The current in vivo biopanning lacks inbuilt mechanisms to select for peptides capable of vascular homing that would also be capable of tissue penetration to reach therapeutically relevant cells in the tissue parenchyma. Here, we combined in vivo phage display with microdialysis-based parenchymal recovery and high-throughput sequencing to select for peptides that, besides va
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Enbäck, J., and P. Laakkonen. "Tumour-homing peptides: tools for targeting, imaging and destruction." Biochemical Society Transactions 35, no. 4 (2007): 780–83. http://dx.doi.org/10.1042/bst0350780.

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Each normal organ and pathological condition contains organ- or disease-specific molecular tags on its vasculature that constitute a vascular ‘zip code’ system. Tissue-selective tumour metastasis may also depend on vascular addresses. We have used phage display peptide libraries to map disease-specific differences in the vasculature. By using this technology, we have isolated several peptides which are targeted specifically to tumour blood vessels, lymphatic vessels and/or tumour cells. Some of the tumour-homing peptides recognize common angiogenesis markers and are capable of binding to sever
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Kawada, Tsuyoshi, Michio Ogasawara, Toshio Sekiguchi, et al. "Peptidomic Analysis of the Central Nervous System of the Protochordate, Ciona intestinalis: Homologs and Prototypes of Vertebrate Peptides and Novel Peptides." Endocrinology 152, no. 6 (2011): 2416–27. http://dx.doi.org/10.1210/en.2010-1348.

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The phylogenetic position of ascidians as the chordate invertebrates closest to vertebrates suggests that they might possess homologs and/or prototypes of vertebrate peptide hormones and neuropeptides as well as ascidian-specific peptides. However, only a small number of peptides have so far been identified in ascidians. In the present study, we have identified various peptides in the ascidian, Ciona intestinalis. Mass spectrometry-based peptidomic analysis detected 33 peptides, including 26 novel peptides, from C. intestinalis. The ascidian peptides are largely classified into three categorie
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Dissertations / Theses on the topic "Tissue-specific peptides"

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Garcia, Javier S. "Temporal and Tissue Specific Changes in Expression of Nutrient Transporters and Host Defense Peptides in Young Broilers during Salmonella and Campylobacter infections." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/86236.

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Salmonella and Campylobacter are the leading causes of bacterial foodborne illness in the United States. Commonly found in the gastrointestinal tract of poultry, Salmonella and Campylobacter may show little to no signs of infection in birds. The objective of this dissertation was to evaluate the influence on mRNA abundance of nutrient transporters and host defense peptides (HDPs) during a Salmonella or a Campylobacter challenge in young commercial broilers. Comparisons were made between non-challenged and challenged (106, 107, or 108 colony forming units of Salmonella or Campylobacter) broil
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Щудрова, Т. С., С. П. Пасевич та Т. Г. Копчук. "Гістоструктура нирок щурів при застосуванні тканиноспецифічних пептидів за умов ішемічно-реперфузійного ураження". Thesis, Сумський державний університет, 2015. http://essuir.sumdu.edu.ua/handle/123456789/41770.

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Ішемічно-реперфузійне ураження (І/Р) – це головна причина клінічної маніфестації гострого ураження нирок та його наслідків, розвиток якого заснований на комплексній взаємодії між судинними, канальцевими та запальними факторами. Сучасні доклінічні дослідження спрямовані на пошук засобів для попередження та покращення перебігу І/Р, що здатні впливати на судинний тонус, обмежувати розвиток оксидативного стресу та запалення, а також захищати клітини канальців від ушкодження і сприяти їх регенерації у процесі відновлення.
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Tavano, Eveline Carla da Rocha. "Transformação genética de Citrus sinensis (L.) Osbeck para resistência a Candidatus Liberibacter ssp." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/64/64133/tde-22042013-161909/.

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A doença Huanglongbing (HLB) associada a bactéria Candidatus Liberibacter spp., que coloniza os vasos do floema, é considerada uma das mais graves doenças de citros. Uma importante estratégia para o controle desta doença consiste na produção de plantas transgênicas, expressando genes que codificam peptídeos antibacterianos especificamente no local de colonização do patógeno. O objetivo deste trabalho foi obter plantas transgênicas de laranja doce, expressando o gene que codifica o peptídeo antibacteriano atacina A (attA) dirigido por promotores específicos para a expressão gênica no floema. O
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Zwarycz, Bailey. "Tissue- and Development-specific Expression of Proton-mediated Peptide Transporters in the Developing Chicken." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/43761.

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PepT1, PepT2 and PHT1 are all members of the proton-coupled oligopeptide transporter family, which are important in the transport of amino acids in peptide form. PepT1 acts as a low affinity/high capacity transporter and PepT2 as a high affinity/low capacity transporter for di- and tri-peptides. PHT1 transports di- and tri-peptides as well as histidine. The objective of this study was to profile PepT1, PepT2 and PHT1 mRNA expression in the proventriculus, duodenum, jejunum, ileum, ceca, large intestine, brain, heart, bursa of Fabricius, lung, kidney, and liver in layer chicks on embryonic days
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Shi, Xiarong. "Mitochondrial Dysfunction and AKT Isoform-Specific Regulation in 3T3-L1 Adipocytes: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/505.

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Excess food consumption and/or lack of exercise have dramatically contributed to the prevalence of overweight (BMI≥25) and obesity (BMI≥30) in modern society. The obesity epidemic has been linked to the rise in type 2 diabetes. In recent years, evidence has pointed to a close association between mitochondrial dysfunction in white adipose tissue (WAT) and insulin resistance, a key feature of type 2 diabetes. In order to dissect the cause and effect relationship between WAT mitochondrial dysfunction and insulin resistance, we established an in vitro cell line system to investigate this issue. We
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Shi, Xiarong. "Mitochondrial Dysfunction and AKT Isoform-Specific Regulation in 3T3-L1 Adipocytes: A Dissertation." eScholarship@UMMS, 2009. http://escholarship.umassmed.edu/gsbs_diss/505.

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Excess food consumption and/or lack of exercise have dramatically contributed to the prevalence of overweight (BMI≥25) and obesity (BMI≥30) in modern society. The obesity epidemic has been linked to the rise in type 2 diabetes. In recent years, evidence has pointed to a close association between mitochondrial dysfunction in white adipose tissue (WAT) and insulin resistance, a key feature of type 2 diabetes. In order to dissect the cause and effect relationship between WAT mitochondrial dysfunction and insulin resistance, we established an in vitro cell line system to investigate this issue. We
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Körbelin, Jakob [Verfasser], and Martin [Akademischer Betreuer] Trepel. "Generation of tissue-specific vectors by in vivo selection of random peptide libraries displayed on the surface of adeno-associated virus type 2 / Jakob Körbelin. Betreuer: Martin Trepel." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1101695889/34.

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Körbelin, Jakob Verfasser], and Martin [Akademischer Betreuer] [Trepel. "Generation of tissue-specific vectors by in vivo selection of random peptide libraries displayed on the surface of adeno-associated virus type 2 / Jakob Körbelin. Betreuer: Martin Trepel." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://nbn-resolving.de/urn:nbn:de:gbv:18-65666.

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Books on the topic "Tissue-specific peptides"

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Keshav, Satish, and Alexandra Kent. Immunology and genetics in gastrointestinal and hepatic medicine. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0196.

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The gut has a pivotal role in immune homeostasis. It is constantly exposed to a wide array of antigens in food, and resident and consumed microorganisms. It is estimated that the number of bacterial cells in the gastrointestinal tract is tenfold greater than the number of cells in the human body. The gut needs to recognize harmful bacteria, and consequently contains the largest number of immune cells in the body. However, it must remain tolerant to commensal bacteria. Bacteria express antigens that stimulate an immunological response via the gut-associated lymphoid tissue (GALT). The GALT incl
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Noordenbos, Troy, and Dominique Baeten. Immune mechanisms: innate immunity. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198734444.003.0007.

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Innate immune mechanisms are strongly implied in the pathophysiology of spondyloarthritis (SpA). This chapter discusses available data on the role of the innate immune system in relation to HLA-B27, genetic associations, and the cellular and molecular characteristics of disease target tissue. Regarding the linkage with MCH-class I molecule HLA-B27, the chapter discusses the arthritogenic peptide hypothesis and three popular antigen-independent theories. The genetic architecture of the disease argues against a role for the adaptive immune system and identifies cytokine pathways, such as IL-1, T
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Book chapters on the topic "Tissue-specific peptides"

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Heemskerk, Hans. "Identification of Peptides for Tissue-Specific Delivery." In Methods in Molecular Biology. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-767-5_24.

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Burton, James. "The design and testing of specific inhibitors of tissue kallikrein: Role of the enzyme in blood pressure regulation." In Peptides. Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-010-9595-2_194.

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Hörger, Susanne, Brigitte Gallert, Josef Kellermann, and Wolfgang Voelter. "Isolation and structural identification of β-thymosins from equine tissue: Development of a specific ELISA against thymosin β10 (Tβ10)." In Peptides 1992. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1470-7_343.

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Blischenko, Elena Yu, Olga V. Sazonova, Sergei V. Khaidukov, et al. "Components of Tissue-Specific Peptide Pools as Negative Regulators of Cell Growth." In Peptides: The Wave of the Future. Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0464-0_376.

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Reichelt, K. L., K. Elgjo, J. E. Paulsen, and Ø. Skraastad. "SMALL PEPTIDES MAY BE TISSUE SPECIFIC MITOSIS INHIBITORS INDUCING TERMINAL DIFFERENTIATION." In Porto Carras, Chalkidiki, Greece, Aug. 31–Sept. 5, 1986, edited by Dimitrios Theodoropoulos. De Gruyter, 1987. http://dx.doi.org/10.1515/9783110864243-149.

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Freed, John H., and Philippa Marrack. "Tissue-Specific Expression of Self Peptides Bound by Major Histocompatibility Complex Class II Molecules." In Chemical Immunology and Allergy. KARGER, 1993. http://dx.doi.org/10.1159/000319183.

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Assadi, Majid, Reza Nemati, Hossein Shooli, and Hojjat Ahmadzadehfar. "Radionuclide Therapy in Brain Tumours." In Beyond Becquerel and Biology to Precision Radiomolecular Oncology: Festschrift in Honor of Richard P. Baum. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-33533-4_10.

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AbstractGlioblastoma multiforme (GBM), the most common primary brain tumour, is also the most aggressive neoplasm in the brain. It is characterized by a very poor prognosis with a median overall survival time of only 9–15 months. The infiltrating nature of the tumour cells, inter- and intra-tumoral molecular heterogeneity and the tumour’s propensity to hide behind the blood-brain barrier are the key causes of the insufficiency of the optimal available treatments (surgery, radiotherapy and chemotherapy). Furthermore, the best treatment strategy for patients with recurrent GBM remains uncertain
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Betts, Corinne A., Suzan M. Hammond, Hai-fang Yin, and Matthew J. A. Wood. "Optimizing Tissue-Specific Antisense Oligonucleotide–Peptide Conjugates." In Methods in Molecular Biology. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-767-5_27.

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Zahid, Maliha, and Paul D. Robbins. "Identification and Characterization of Tissue-Specific Protein Transduction Domains Using Peptide Phage Display." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-919-2_20.

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Rey, Jose I., Haihong Huang, Ling Sheng, et al. "In vivo Imaging Using Tissue Specific Near Infrared fluorescent Peptide Conjugate, c[RGDyK(HiLyte Fluor™ 750)]." In Advances in Experimental Medicine and Biology. Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-73657-0_193.

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Conference papers on the topic "Tissue-specific peptides"

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Rawal, Atul, Kristen L. Rhinehardt, and Ram V. Mohan. "Mechanical Behavior of Collagen Mimetic Peptides Under Fraying Deformation via Molecular Dynamics." In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-11492.

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Abstract Collagen is a pervasive, triple helical, extracellular matrix (ECM) protein, found in human body from skin and bones to blood vessels and lungs, making it biocompatible, biodegradable, capable of cell attachment, and relevant for applications in bio-polymers, tissue engineering and a plethora of other bio-medical fields. Natural collagen’s extraction from natural sources is time consuming, sometimes costly, and it is difficult to render, and could present undesired biological and pathogenic changes. Nanoscale collagen mimetic peptides (Synthetic Collagen), without the unwanted biologi
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Jabbari, Esmaiel, David N. Rocheleau, Weijie Xu, and Xuezhong He. "Fabrication of Biomimetic Scaffolds With Well-Defined Pore Geometry by Fused Deposition Modeling." In ASME 2007 International Manufacturing Science and Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/msec2007-31011.

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It is well established that the pore size and distribution affect the rate of cell migration and the extent of extracellular matrix formation. The objective of this work was to develop a process for fabrication of biodegradable and shape-specific polymeric scaffolds with well-defined pore geometry, functionalized with covalently attached bioactive peptides, for applications in tissue regeneration. We have used the Fused Deposition Modeling (FDM) RP technology to fabricate degradable and functional scaffolds with well-defined pore geometry. Computer aided design (CAD) using SolidWorks was used
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Zacharski, L., V. Memoli, and S. Rousseau. "THROMBIN-SPECIFIC SITESOF FIBRINOGEN IN SMALL CELL CARCINOMA OF THE LUNG." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643670.

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Thrombin-generated cleavage sites of human fibrinogen have been identified within the connective tissue stroma adjacent to viable tumor cells in fresh frozen sections of small cell carcinomaof the lung (SCCL) by means of immunohistochemical techniques using mouse monoclonal antibodies (designated alpha and beta) to the N-terminal peptides of the fibrinogen alpha and beta chains(provided by G. Matsueda and E. Haber).Specific connective tissue staining with antibody alpha was diffuse while staining with antibody beta was linear and focal. These results indicate thatthrombin is generated in situ
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Sugahara, Kazuki N., Gary B. Braun, Tatiana H. de Mendoza, et al. "Abstract LB-102: A tumor-specific tissue penetrating peptide inhibits metastasis." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-lb-102.

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Sadler, J. Evan. "THE MOLECULAR BIOLOGY OF VON WILLEBRAND FACTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643930.

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Human von Willebrand factor (vWF) is a plasma glycoprotein that is synthesized by endothelial cells and megakaryocytes, and perhaps by syncytiotrophoblast of placenta. The biosynthesis of vWF is very complex, involving proteolytic processing, glycosyla-tion, disulfide bond formation, and sulfation. Mature vWF consists of a single subunit of ∼ 250,000 daltons that is assembled into multimer ranging from dimers to species of over 10 million daltons. vWF performs its essential hemostatic function through several binding interactions, forming a bridge between specific receptors on the platelet sur
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Cho, Hongkwan, Abdul Sheikh, and Daria A. Narmoneva. "Non-Specific Endothelial Cell Interactions With the Substrate Result in Cell Activation and Angiogenesis In Vitro." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19094.

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Vascularization is critical for success of tissue engineering applications. Previous studies by us and others have shown that self-assembling peptide nanoscaffold RAD16-II promotes de novo capillary formation (angiogenesis) in vitro and neovascularization in vivo, and is a promising material for tissue engineering applications [1, 2]. However, the molecular mechanisms for cell interactions with this material are not known. Angiogenesis is mediated via interactions between integrins, which are expressed on the surface of activated endothelial cells (ECs), and extracellular matrix proteins. Amon
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Deshane, J., K. Goliwas, V. J. Thannickal, K. S. Harrod, and J. Donahue. "Local SARS-CoV-2 Peptide-specific Immune Responses in Convalescent and Uninfected Human Lung Tissue Models." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3689.

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Yoshikawa, Toshiaki, Mayuko Sakai, Kazuya Ofuji, et al. "Abstract B73: Proof of glypican-3 (GPC3) peptide specific CTLs infiltrating into tumor tissue derived from advanced HCC patient vaccinated with GPC3 peptide." In Abstracts: AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; December 2-5, 2012; Miami, FL. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.tumimm2012-b73.

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Bauer, K. A., B. L. Kass, M. Bednarek, M. Kloczewiak, J. Hawiger, and R. D. Rosenberg. "DETECTION OF FACTOR X ACTIVATION IN HUMANS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643828.

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The activation of factor X by factor VII/VIIa-tissue factor or factor IXa plays a pivotal role in the hemostatic mechanism. This reaction results in the liberation of a peptide from the zymogen for which we have developed a sensitive and specific radioimmunoassay (RIA), The native peptide was purified from activated human factor X by hydroxylapatite chromatography and reverse-phase high pressure liquid chromatography (HPLC). Gel filtration experiments demonstrated that the peptide was not physically associated with the enzyme. A 15 amino acid peptide with the COOH-terminal sequence of the acti
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10

Pogodaeva, P. S. "Changes in the parameters of a clinical blood test in rats using hypoglycemic agents for the potentiation of drugs with a hepatoprotective effect." In SPbVetScience. FSBEI HE St. Petersburg SUVM, 2023. http://dx.doi.org/10.52419/3006-2023-11-28-34.

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Glucagon-like peptide-1 is an isulin-like peptide hormone from the incretin family. The most popular pharmaceutical analogue of GLP-1 at the moment is liraglutide. GLP-1 receptors are localized in many areas of the brain responsible for the regulation of metabolic processes and eating behavior and in specific areas of the pancreas, heart, blood vessels, immune system, skin and adipose tissue, gastrointestinal tract and kidneys. We can definitely say that the effect of liraglutide extends to all tissues equipped with GLP-1 receptors, while the effect of the drug on the cardiovascular system, im
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Reports on the topic "Tissue-specific peptides"

1

Altstein, Miriam, and Ronald Nachman. Rationally designed insect neuropeptide agonists and antagonists: application for the characterization of the pyrokinin/Pban mechanisms of action in insects. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7587235.bard.

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The general objective of this BARD project focused on rationally designed insect neuropeptide (NP) agonists and antagonists, their application for the characterization of the mechanisms of action of the pyrokinin/PBAN (PK-PBAN) family and the development of biostable, bioavailable versions that can provide the basis for development of novel, environmentally-friendly pest insect control agents. The specific objectives of the study, as originally proposed, were to: (i) Test stimulatory potencies of rationally designed backbone cyclic (BBC) peptides on pheromonotropic, melanotropic, myotropic and
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Rafaeli, Ada, and Russell Jurenka. Molecular Characterization of PBAN G-protein Coupled Receptors in Moth Pest Species: Design of Antagonists. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7593390.bard.

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The proposed research was directed at determining the activation/binding domains and gene regulation of the PBAN-R’s thereby providing information for the design and screening of potential PBAN-R-blockers and to indicate possible ways of preventing the process from proceeding to its completion. Our specific aims included: (1) The identification of the PBAN-R binding domain by a combination of: (a) in silico modeling studies for identifying specific amino-acid side chains that are likely to be involved in binding PBAN with the receptor and; (b) bioassays to verify the modeling studies using mut
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3

Noga, Edward J., Angelo Colorni, Michael G. Levy, and Ramy Avtalion. Importance of Endobiotics in Defense against Protozoan Ectoparasites of Fish. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7586463.bard.

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Infectious disease is one of the most serious causes of economic loss in all sectors of aquaculture. There is a critical need to understand the molecular basis for protection against infectious disease so that safer, more reliable and more cost-effective strategies can be designed for their control. As part of this effort, the major goal of our BARD project was to determine the importance of endobiotics as a defense against protozoan ectoparasites in fish. Endobiotics, or antimicrobial polypeptides, are peptides and small proteins that are increasingly recognized as having a vital role in the
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4

Loebenstein, Gad, William Dawson, and Abed Gera. Association of the IVR Gene with Virus Localization and Resistance. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7604922.bard.

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We have reported that localization of TMV in tobacco cultivars with the N gene, is associated with a 23 K protein (IVR) that inhibited replication of several plant viruses. This protein was also found in induced resistant tissue of Nicotiana glutinosa x Nicotiana debneyi. During the present grant we found that TMV production is enhanced in protoplasts and plants of local lesion responding tobacco cultivars exposed to 35oC, parallel to an almost complete suppression of the production of IVR. We also found that IVR is associated with resistance mechanisms in pepper cultivars. We succeeded to clo
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5

Reisch, Bruce, Avichai Perl, Julie Kikkert, Ruth Ben-Arie, and Rachel Gollop. Use of Anti-Fungal Gene Synergisms for Improved Foliar and Fruit Disease Tolerance in Transgenic Grapes. United States Department of Agriculture, 2002. http://dx.doi.org/10.32747/2002.7575292.bard.

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Original objectives . 1. Test anti-fungal gene products for activity against Uncinula necator, Aspergillus niger, Rhizopus stolonifer and Botrytis cinerea. 2. For Agrobacterium transformation, design appropriate vectors with gene combinations. 3. Use biolistic bombardment and Agrobacterium for transformation of important cultivars. 4. Characterize gene expression in transformants, as well as level of powdery mildew and Botrytis resistance in foliage of transformed plants. Background The production of new grape cultivars by conventional breeding is a complex and time-consuming process. Transfer
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