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Journal articles on the topic 'Tissue-specific peptides'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Ivanov, Vadim T., Oleg N. Yatskin, Olga A. Kalinina, Marina M. Philippova, Andrei A. Karelin, and Elena Yu Blishchenko Shemyakin-Ovchinnikov. "Tissue-specific peptide pools. Generation and function." Pure and Applied Chemistry 72, no. 3 (2000): 355–63. http://dx.doi.org/10.1351/pac200072030355.

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Systematic analysis of several tissue extracts for peptide components followed by bioactivity studies leads to formulation of the concept of "tissue-specific peptide pools". According to that concept the endogenous proteolysis of proteins with well-established functions, such as hemoglobin, actin, and cellular enzymes in tissues leads to formation of the sets (or pools) of bioactive peptides. The sets are tissue-specific on one hand and conservative in a given tissue at normal conditions on the other. The content and the composition of pool components are sensitive both to pathologies linked w

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Nelson, Ryan, and Marc Jenkins. "Implications of T cell receptor cross-reactivity on the CD4+ T cell repertoire (APP3P.111)." Journal of Immunology 194, no. 1_Supplement (2015): 113.12. http://dx.doi.org/10.4049/jimmunol.194.supp.113.12.

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Abstract Naïve CD4+ T cell populations with T cell receptors (TCR) specific for different major histocompatibility complex II (MHCII)-bound foreign peptides vary in size for unknown reasons. Negative selection on self peptides could play a role. We found that MHCII-binding nonamer peptides only had to have the same residues at five positions to be recognized by the same TCR. This degree of TCR cross-reactivity between self and foreign peptides reduced the sizes of foreign peptide-specific T cell populations via clonal deletion. Small foreign p:MHCII-specific populations that underwent a greate

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Fortier, Marie-Hélène, Etienne Caron, Marie-Pierre Hardy, et al. "The MHC I Immunopeptidome Is Moulded by the Transcriptome and Conceals a Tissue-Specific Signature." Blood 110, no. 11 (2007): 1327. http://dx.doi.org/10.1182/blood.v110.11.1327.1327.

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Abstract Background: Cell surface MHC I molecules are associated with self peptides that are collectively referred to as the self MHC I immunopeptidome (sMII). The sMII plays vital roles: it shapes the repertoire of developing thymocytes, transmits survival signals to mature CD8 T cells, amplifies responses against intracellular pathogens, allows immunosurveillance of neoplastic cells, and influences mating preferences in mice. Despite the tremendous importance of the sMII, very little is known on its genesis and molecular composition. Methodology/Principal Findings: We developed a novel high-

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Amir, Avital, Marieke Griffioen, Michel D. G. Kester, et al. "Allo-HLA Reactive CD8 T-Cells May Recognize Tissue Specific Peptides Explaining Tissue Restricted GVHD after HLA Mismatched SCT." Blood 110, no. 11 (2007): 72. http://dx.doi.org/10.1182/blood.v110.11.72.72.

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Abstract HLA disparity between patient and donor increases the risk of GVHD after allogeneic stem cell transplantation (SCT). However, similar to fully HLA matched SCT, the clinical manifestation of GVHD after HLA mismatched SCT is frequently restricted to skin, gut and liver. Based on the frequency of allo-HLA reactive T-cells, which is about a 1000-fold higher than the frequency of minor histocompatibility antigen specific T-cells, the immune response after HLA mismatched SCT is expected to be mediated by allo-HLA reactive T-cells. Theoretically allo-HLA reactive T-cells can exert three diff

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Pruksakorn, S., A. Galbraith, R. A. Houghten, and M. F. Good. "Conserved T and B cell epitopes on the M protein of group A streptococci. Induction of bactericidal antibodies." Journal of Immunology 149, no. 8 (1992): 2729–35. http://dx.doi.org/10.4049/jimmunol.149.8.2729.

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Abstract To identify conserved T and B cell epitopes on the M protein of group A beta-hemolytic streptococci, overlapping synthetic peptides that span the conserved carboxyl-terminal segment of the M-5 protein were constructed and used to immunize a panel of H-2 congenic mice. Proliferative T cell epitopes were identified and, in many cases, mice immunized with these peptides produced high titer antibodies to the same peptides indicating that these proliferative epitopes could also stimulate Th cells. Peptide-specific T cells and antisera were tested for their reactivity with porcine myosin, t

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Papadopoulos, Kyriakos P., Nicole Suciu-Foca, Charles S. Hesdorffer, Sorina Tugulea, Antonella Maffei, and Paul E. Harris. "Naturally Processed Tissue- and Differentiation Stage-Specific Autologous Peptides Bound by HLA Class I and II Molecules of Chronic Myeloid Leukemia Blasts." Blood 90, no. 12 (1997): 4938–46. http://dx.doi.org/10.1182/blood.v90.12.4938.

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Abstract Structural analysis of naturally processed peptides bound to the HLA class I and class II molecules of chronic myeloid leukemia (CML) blast cells was performed to characterize the antigen processing and autoantigen repertoire in this hematopoietic malignancy. Self-peptides derived from the carboxy-terminal end of the breakpoint cluster region (bcr) protein, as well as several differentiation stage- and tissue-specific self-antigens characteristic of early stages of myeloid differentiation, such as c-fes, c-pim, granulocyte-macrophage colony-stimulating factor receptor α chain, protein

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Papadopoulos, Kyriakos P., Nicole Suciu-Foca, Charles S. Hesdorffer, Sorina Tugulea, Antonella Maffei, and Paul E. Harris. "Naturally Processed Tissue- and Differentiation Stage-Specific Autologous Peptides Bound by HLA Class I and II Molecules of Chronic Myeloid Leukemia Blasts." Blood 90, no. 12 (1997): 4938–46. http://dx.doi.org/10.1182/blood.v90.12.4938.4938_4938_4946.

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Structural analysis of naturally processed peptides bound to the HLA class I and class II molecules of chronic myeloid leukemia (CML) blast cells was performed to characterize the antigen processing and autoantigen repertoire in this hematopoietic malignancy. Self-peptides derived from the carboxy-terminal end of the breakpoint cluster region (bcr) protein, as well as several differentiation stage- and tissue-specific self-antigens characteristic of early stages of myeloid differentiation, such as c-fes, c-pim, granulocyte-macrophage colony-stimulating factor receptor α chain, proteinase 3, an

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Pemmari, Toini, Stuart Prince, Niklas Wiss, et al. "Screening of homing and tissue-penetrating peptides by microdialysis and in vivo phage display." Life Science Alliance 8, no. 5 (2025): e202201490. https://doi.org/10.26508/lsa.202201490.

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In vivo phage display is a method used for identification of organ- or disease-specific vascular homing peptides for targeted delivery of pharmaceutics. It is agnostic as to the nature and identity of the target molecules. The current in vivo biopanning lacks inbuilt mechanisms to select for peptides capable of vascular homing that would also be capable of tissue penetration to reach therapeutically relevant cells in the tissue parenchyma. Here, we combined in vivo phage display with microdialysis-based parenchymal recovery and high-throughput sequencing to select for peptides that, besides va

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Enbäck, J., and P. Laakkonen. "Tumour-homing peptides: tools for targeting, imaging and destruction." Biochemical Society Transactions 35, no. 4 (2007): 780–83. http://dx.doi.org/10.1042/bst0350780.

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Each normal organ and pathological condition contains organ- or disease-specific molecular tags on its vasculature that constitute a vascular ‘zip code’ system. Tissue-selective tumour metastasis may also depend on vascular addresses. We have used phage display peptide libraries to map disease-specific differences in the vasculature. By using this technology, we have isolated several peptides which are targeted specifically to tumour blood vessels, lymphatic vessels and/or tumour cells. Some of the tumour-homing peptides recognize common angiogenesis markers and are capable of binding to sever

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Kawada, Tsuyoshi, Michio Ogasawara, Toshio Sekiguchi, et al. "Peptidomic Analysis of the Central Nervous System of the Protochordate, Ciona intestinalis: Homologs and Prototypes of Vertebrate Peptides and Novel Peptides." Endocrinology 152, no. 6 (2011): 2416–27. http://dx.doi.org/10.1210/en.2010-1348.

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The phylogenetic position of ascidians as the chordate invertebrates closest to vertebrates suggests that they might possess homologs and/or prototypes of vertebrate peptide hormones and neuropeptides as well as ascidian-specific peptides. However, only a small number of peptides have so far been identified in ascidians. In the present study, we have identified various peptides in the ascidian, Ciona intestinalis. Mass spectrometry-based peptidomic analysis detected 33 peptides, including 26 novel peptides, from C. intestinalis. The ascidian peptides are largely classified into three categorie

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Davidson, Thomas A., Samantha J. McGoldrick, and David H. Kohn. "Phage Display to Augment Biomaterial Function." International Journal of Molecular Sciences 21, no. 17 (2020): 5994. http://dx.doi.org/10.3390/ijms21175994.

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Biomaterial design relies on controlling interactions between materials and their biological environments to modulate the functions of proteins, cells, and tissues. Phage display is a powerful tool that can be used to discover peptide sequences with high affinity for a desired target. When incorporated into biomaterial design, peptides identified via phage display can functionalize material surfaces to control the interaction between a biomaterial and its local microenvironment. A targeting peptide has high specificity for a given target, allowing for homing a specific protein, cell, tissue, o

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Haen, Sebastian P., Daniel J. Kowalewski, Joerg Bernhardt, et al. "Unique Alterations in the Immunopeptidome of Colorectal Cancer Reflect Specific Transformations in Cancer-Associated Signaling Pathways and Reveal Tumor-Specific HLA-Ligand Modulations." Blood 128, no. 22 (2016): 862. http://dx.doi.org/10.1182/blood.v128.22.862.862.

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Abstract Background: Immunotherapy with checkpoint-inhibitors has shown spectacular results in the treatment of certain cancer types including microsatellite instable colorectal cancer (CRC). Applicability is believed to be dependent on the number of potential neo-epitopes derived from genetic mutations that are presented on cancer cells. In case of most microsatellite-stable CRC however, clinical responses to immune checkpoint blockade are so far disappointing. Therefore, we analyzed the non-mutant HLA immunopeptidome of CRC in order to provide an extensive dataset for the development of immu

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Vojdani, Aristo, Mohsen Bazargan, Elroy Vojdani, et al. "Heat Shock Protein and Gliadin Peptide Promote Development of Peptidase Antibodies in Children with Autism and Patients with Autoimmune Disease." Clinical Diagnostic Laboratory Immunology 11, no. 3 (2004): 515–24. http://dx.doi.org/10.1128/cdli.11.3.515-524.2004.

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ABSTRACT Searching for a mechanism underlying autoimmunity in autism, we postulated that gliadin peptides, heat shock protein 60 (HSP-60), and streptokinase (SK) bind to different peptidases resulting in autoantibody production against these components. We assessed this hypothesis in patients with autism and in those with mixed connective tissue diseases. Associated with antigliadin and anti-HSP antibodies, children with autism and patients with autoimmune disease developed anti-dipeptidylpeptidase I (DPP I), anti-dipeptidylpeptidase IV (DPP IV [or CD26]) and anti-aminopeptidase N (CD13) autoa

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Ganapathy, V., and F. H. Leibach. "Carrier-mediated reabsorption of small peptides in renal proximal tubule." American Journal of Physiology-Renal Physiology 251, no. 6 (1986): F945—F953. http://dx.doi.org/10.1152/ajprenal.1986.251.6.f945.

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Recent studies with a variety of tissue preparations in the kidney have demonstrated that proximal tubular cells possess specific transport systems for di- and tripeptides. In contrast to the well-known amino acid and glucose transport systems, active transport of peptides in these cells is energized by an H+ gradient rather than an Na+ gradient. Like amino acid-Na+ and glucose-Na+ cotransport systems, peptide-H+ cotransport is electrogenic and hence a membrane potential also contributes to the uphill transport of peptides in these cells. Di- and tripeptides that are filtered at the glomerulus

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Hozumi, Kentaro, and Motoyoshi Nomizu. "Mixed Peptide-Conjugated Chitosan Matrices as Multi-Receptor Targeted Cell-Adhesive Scaffolds." International Journal of Molecular Sciences 19, no. 9 (2018): 2713. http://dx.doi.org/10.3390/ijms19092713.

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Biomaterials are important for cell and tissue engineering. Chitosan is widely used as a scaffold because it is easily modified using its amino groups, can easily form a matrix, is stable under physiological conditions, and is inactive for cell adhesion. Chitosan is an excellent platform for peptide ligands, especially cell adhesive peptides derived from extracellular matrix (ECM) proteins. ECM proteins, such as collagen, fibronectin, and laminin, are multifunctional and have diverse cell attachment sites. Various cell adhesive peptides have been identified from the ECM proteins, and these are

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Hall, Charles E., Max Jameson-Lee, Abdelrhman Elnasseh, et al. "Peptides Derived from the CMV Proteome Mimic Unique Stem Cell Transplant Recipient Specific Peptides: Possible Role in Eliciting a Pro-Gvh T Cell Response." Blood 126, no. 23 (2015): 4285. http://dx.doi.org/10.1182/blood.v126.23.4285.4285.

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Abstract Stem cell transplant (SCT) recipients who develop human cytomegalovirus (hCMV) reactivation are at risk of developing graft versus host disease (GVHD). This may stem from immune cross reactivity (Figure 1) towards both pathogen-derived peptides and nearly identical recipient-derived alloreactive peptide minor histocompatibility antigens from SCT donor-recipient pairs (DRP). Whole exome sequencing was performed on 9 SCT DRP, and the resulting nucleotide sequences aligned and compared, identifying all the single nucleotide polymorphisms (SNPs) present in the recipient and absent in the

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Aleanzi, Mabel, Ana María Demonte, Cecilia Esper, Silvia Garcilazo, and Marta Waggener. "Celiac Disease." Clinical Chemistry 47, no. 11 (2001): 2023–28. http://dx.doi.org/10.1093/clinchem/47.11.2023.

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Abstract Background: Selective deamidation of glutamine residues by tissue transglutaminase (tTG) turns gliadin peptides into stronger activators of T cells from celiac disease (CD) patients. We examined the possibility that these modified peptides could be more specific epitopes for circulating antibodies than are native peptides. Methods: Two native synthetic peptides and their respective modified sequences were used as antigens for ELISA assays: peptide-1, with residues 56–75 of α-type gliadin; and peptide-2, with residues 134–153 of γ-type gliadin. We examined 40 CD patients [31 not being

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Turner, R. T., L. S. Kidder, M. Zhang, et al. "Estrogen has rapid tissue-specific effects on rat bone." Journal of Applied Physiology 86, no. 6 (1999): 1950–58. http://dx.doi.org/10.1152/jappl.1999.86.6.1950.

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The decrease in cancellous bone formation after estrogen treatment is generally thought to be coupled with a prior decrease in bone resorption. To test the possibility that estrogen has rapid tissue-specific actions on bone metabolism, we determined the time course (1–32 h) effects of diethylstilbestrol on steady-state mRNA levels for immediate-response genes, extracellular matrix proteins, and signaling peptides in the proximal tibial metaphysis and uterus by using Northern blot and RNase protection assays. The regulation of signaling peptides by estrogen, although tissue specific, followed a

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Anandalakshmi, Venkatraman, Guillaume Hochart, David Bonnel, et al. "Targeted Expression of TGFBIp Peptides in Mouse and Human Tissue by MALDI-Mass Spectrometry Imaging." Separations 8, no. 7 (2021): 97. http://dx.doi.org/10.3390/separations8070097.

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Stromal corneal dystrophies are a group of hereditary disorders caused by mutations in the TGFBI gene. The mutant TGFBIp is prone to protein aggregation and the mutant protein gets deposited in the cornea, leading to severe visual impairment. The mutations lead to a corneal specific protein aggregation suggesting the involvement of tissue-specific factors. The exact molecular mechanism of the process of tissue-specific protein aggregation remains to be elucidated. Differential proteolysis of mutant TGFBIp is a critical component of the disease pathology. The differential proteolysis gives rise

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Haen, Sebastian P., Daniel Johannes Kowalewski, Stefan Stevanovic, et al. "Interplay Between the Immune System and Colorectal Carcinoma - Towards Tumor-Specific Peptide-Based Vaccination for Any HLA-Type." Blood 126, no. 23 (2015): 1027. http://dx.doi.org/10.1182/blood.v126.23.1027.1027.

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Abstract Introduction: Peptide-basedcancer vaccines targeting tumor-associated antigens comprised of synthetic peptides have shown promising clinical results and have progressed to Phase III clinical testing in several tumor entities, including colorectal carcinoma (CRC). As of yet, these vaccines have typically been limited to HLA-A*02 positive patients, which means that more than half of the patient pool will not be eligible for those treatment strategies. The development of novel strategies for vaccine design, which are applicable to a larger fraction of potential patients, is therefore req

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Lyapina, Irina, Vadim Ivanov, and Igor Fesenko. "Peptidome: Chaos or Inevitability." International Journal of Molecular Sciences 22, no. 23 (2021): 13128. http://dx.doi.org/10.3390/ijms222313128.

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Thousands of naturally occurring peptides differing in their origin, abundance and possible functions have been identified in the tissue and biological fluids of vertebrates, insects, fungi, plants and bacteria. These peptide pools are referred to as intracellular or extracellular peptidomes, and besides a small proportion of well-characterized peptide hormones and defense peptides, are poorly characterized. However, a growing body of evidence suggests that unknown bioactive peptides are hidden in the peptidomes of different organisms. In this review, we present a comprehensive overview of the

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Wu, M. X., T. J. Tsomides, and H. N. Eisen. "Tissue distribution of natural peptides derived from a ubiquitous dehydrogenase, including a novel liver-specific peptide that demonstrates the pronounced specificity of low affinity T cell reactions." Journal of Immunology 154, no. 9 (1995): 4495–502. http://dx.doi.org/10.4049/jimmunol.154.9.4495.

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Abstract The peptides recognized by CD8+ CTL normally arise by proteolysis of intracellular proteins. To learn whether these peptides are generated similarly in diverse cell types, we examined the variety and abundance of naturally processed peptides that derive from a ubiquitous enzyme, alpha-ketoglutarate dehydrogenase, and are recognized in association with the class I MHC protein, Ld, by a CTL clone (2C). A characteristic set of three peptides was found in diverse tissues, but their abundance varied greatly, apparently unrelated to differences in class I MHC expression, e.g., they were sur

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Wettstein, P. J., G. M. van Bleek, and S. G. Nathenson. "Differential binding of a minor histocompatibility antigen peptide to H-2 class I molecules correlates with immune responsiveness." Journal of Immunology 150, no. 7 (1993): 2753–60. http://dx.doi.org/10.4049/jimmunol.150.7.2753.

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Abstract Minor histocompatibility (H) Ag are recognized in the context of MHC class I (K/D) molecules and can constitute a strong barrier to tissue transplantation. The products encoded by the MHC (H-2 in mice) have been shown recently to be Ag-presenting molecules that bind foreign and self peptides in their peptide binding sites. Different class I molecules preferentially bind different arrays of endogenous peptides for presentation to CTL. Previous studies showed that the Kb-restricted CTL response to one minor histocompatibility Ag, H-4, varied in different Kb mutants. One possible basis f

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Poindexter, N. J., B. Naziruddin, D. W. McCourt, and T. Mohanakumar. "Isolation of a kidney-specific peptide recognized by alloreactive HLA-A3-restricted human CTL." Journal of Immunology 154, no. 8 (1995): 3880–87. http://dx.doi.org/10.4049/jimmunol.154.8.3880.

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Abstract The molecular nature of tissue-specific Ags involved in MHC-restricted CTL responses is as yet undefined. To determine the specificity of these peptides, their function, and their possible relationship to allograft rejection, we have utilized human kidney-specific CD8+ CTL clones to screen reversed-phase HPLC (RP-HPLC)-separated self peptides presented by allo-class I molecules. One of these clones is HLA-A3-restricted and the other HLA-B62-restricted, lysing human kidney cell lines but not MHC identical B lymphoblastoid cells which express the appropriate HLA molecules. We have ident

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Marrack, P., L. Ignatowicz, J. W. Kappler, J. Boymel, and J. H. Freed. "Comparison of peptides bound to spleen and thymus class II." Journal of Experimental Medicine 178, no. 6 (1993): 2173–83. http://dx.doi.org/10.1084/jem.178.6.2173.

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In the past we and others have suggested that positive selection of developing thymocytes may depend upon interaction between the alpha beta receptors on these cells and major histocompatibility complex (MHC) proteins bound to peptides found uniquely in the selecting tissue, thymus cortical epithelium. To test this hypothesis, peptides were isolated from MHC class II proteins of spleen, thymus cortical plus medullary epithelium, or thymus cortical epithelium alone. The results showed that the major peptides bound to class II on thymus cortical epithelium were also associated with spleen class

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Barrett, J. "Chairman's Concluding Remarks." Parasitology 102, S1 (1991): S117—S118. http://dx.doi.org/10.1017/s0031182000073340.

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Although structurally simple, the nervous systems of parasitic helminths are biochemically complex. As well as the classical transmitters, the nervous systems of helminths contain a range of regulatory peptides and so far some 29 different peptides have been described. The only group of compounds thought to be transmitters in free-living organisms which have not yet been shown to be transmitters in helminths are the purines. There is evidence in helminths, as in vertebrates, for the co-localization, in the same cell, of classical transmitters and peptidergic molecules and for the non-neuronal

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Daiko, H., T. Marafioti, T. Fujiwara, et al. "Exploratory open-label clinical study to determine the S-588410 cancer peptide vaccine-induced tumor-infiltrating lymphocytes and changes in the tumor microenvironment in esophageal cancer patients." Cancer Immunology, Immunotherapy 69, no. 11 (2020): 2247–57. http://dx.doi.org/10.1007/s00262-020-02619-3.

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Abstract Cancer vaccines induce cancer-specific T-cells capable of eradicating cancer cells. The impact of cancer peptide vaccines (CPV) on the tumor microenvironment (TME) remains unclear. S-588410 is a CPV comprising five human leukocyte antigen (HLA)-A*24:02-restricted peptides derived from five cancer testis antigens, DEPDC1, MPHOSPH1, URLC10, CDCA1 and KOC1, which are overexpressed in esophageal cancer. This exploratory study investigated the immunologic mechanism of action of subcutaneous S-588410 emulsified with MONTANIDE ISA51VG adjuvant (median: 5 doses) by analyzing the expression of

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Kirkham, J., A. Firth, D. Vernals, et al. "Self-assembling Peptide Scaffolds Promote Enamel Remineralization." Journal of Dental Research 86, no. 5 (2007): 426–30. http://dx.doi.org/10.1177/154405910708600507.

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Rationally designed β-sheet-forming peptides that spontaneously form three-dimensional fibrillar scaffolds in response to specific environmental triggers may potentially be used in skeletal tissue engineering, including the treatment/prevention of dental caries, via bioactive surface groups. We hypothesized that infiltration of caries lesions with monomeric low-viscosity peptide solutions would be followed by in situ polymerization triggered by conditions of pH and ionic strength, providing a biomimetic scaffold capable of hydroxyapatite nucleation, promoting repair. Our aim was to determine t

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Khvostov, Daniil, Natalya Vostrikova, and Irina M. Chernukha. "PSV-25 Detection of heart and aorta tissue peptide markers by the multiple-reaction monitoring method." Journal of Animal Science 98, Supplement_4 (2020): 362–63. http://dx.doi.org/10.1093/jas/skaa278.636.

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Abstract Functional, particularly personalized meat-based foods are of more in demand by a consumer today. Functional additives, such as plant components and animal proteins from bovine or porcine tissues have been successfully used. With many ingredients added to foods, it is important to provide quality and composition monitoring to confirm the products’ authenticity, to identify undeclared or rarely used types of raw meat in product formulations. For example, if animal heart tissue is a component of a product formulation or if aorta tissue presents in a product due to improper trimming. Dif

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Puchalski, Michał, Dmitry Tretiakow, Andrzej Skorek, et al. "Comparison of Peptidomes Extracted from Healthy Tissue and Tumor Tissue of the Parotid Glands and Saliva Samples." International Journal of Molecular Sciences 25, no. 16 (2024): 8799. http://dx.doi.org/10.3390/ijms25168799.

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Salivary gland tumors are highly variable in clinical presentation and histology. The World Health Organization (WHO) classifies 22 types of malignant and 11 types of benign tumors of the salivary glands. Diagnosis of salivary gland tumors is based on imaging (ultrasound, magnetic resonance imaging) and fine-needle aspiration biopsy, but the final diagnosis is based on histopathological examination of the removed tumor tissue. In this pilot study, we are testing a new approach to identifying peptide biomarkers in saliva that can be used to diagnose salivary gland tumors. The research material

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Ermisch, A., H. J. Rühle, R. Landgraf, and J. Hess. "Blood—Brain Barrier and Peptides." Journal of Cerebral Blood Flow & Metabolism 5, no. 3 (1985): 350–57. http://dx.doi.org/10.1038/jcbfm.1985.49.

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The brain is both the source and the recipient of peptide signals. The question is: Do endogenous, blood-borne peptide molecules influence brain function? Brain regions with the tight capillaries of the blood–brain barrier (BBB) extract low but measurable amounts of labeled peptide molecules from an intracarotid bolus injection. In the rat, the extraction fractions of β-casomorphin-5, DesGlyNH2-arginine-vasopressin, arginine-vasopressin, lysine-vasopressin, oxytocin, gonadoliberin, substance P, and β-endorphin, studied in this laboratory, range from 0.5% (substance P) to 2.4% (arginine-vasopre

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Isaac, R. E., R. J. Siviter, P. Stancombe, D. Coates, and A. D. Shirras. "Conserved roles for peptidases in the processing of invertebrate neuropeptides." Biochemical Society Transactions 28, no. 4 (2000): 460–64. http://dx.doi.org/10.1042/bst0280460.

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Invertebrates use a wide range of peptides as transmitters and hormones to regulate complex behaviour, physiology and development. These animals, especially those that are amenable to genetic study and are the subject of genome-sequencing projects, provide powerful model systems for understanding the functions of peptidases in controlling the bioactivity of peptides. Neprilysin, a zinc metallopeptidase and a key enzyme in the metabolism of mammalian peptides, is also implicated in the inactivation of peptides at synapses and of circulating peptide hormones in insects and nematodes. A family of

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Kumar, Vijay Bhooshan, Om Shanker Tiwari, Gal Finkelstein-Zuta, Sigal Rencus-Lazar, and Ehud Gazit. "Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering." Pharmaceutics 15, no. 2 (2023): 345. http://dx.doi.org/10.3390/pharmaceutics15020345.

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Tissue engineering (TE) is a rapidly expanding field aimed at restoring or replacing damaged tissues. In spite of significant advancements, the implementation of TE technologies requires the development of novel, highly biocompatible three-dimensional tissue structures. In this regard, the use of peptide self-assembly is an effective method for developing various tissue structures and surface functionalities. Specifically, the arginine–glycine–aspartic acid (RGD) family of peptides is known to be the most prominent ligand for extracellular integrin receptors. Due to their specific expression p

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Ivanov, Vadim T., Andrei A. Karelin, Marina M. Philippova, Igor V. Nazimov, and Vladimir Z. Pletnev. "Hemoglobin as a source of endogenous bioactive peptides: The concept of tissue-specific peptide pool." Biopolymers 43, no. 2 (1997): 171–88. http://dx.doi.org/10.1002/(sici)1097-0282(1997)43:2<171::aid-bip10>3.0.co;2-o.

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Nemudraya, A. A., V. A. Richter, and E. V. Kuligina. "Phage Peptide Libraries As a Source of Targeted Ligands." Acta Naturae 8, no. 1 (2016): 48–57. http://dx.doi.org/10.32607/20758251-2016-8-1-48-57.

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One of the dominant trends in modern pharmacology is the creation of drugs that act directly on the lesion focus and have minimal toxicity on healthy tissues and organs. This problem is particularly acute in relation to oncologic diseases. Short tissue- and organ-specific peptides capable of delivering drugs to the affected organ or tissue are considered promising targeted agents that can be used in the diagnosis and therapy of diseases, including cancer. The review discusses in detail the technology of phage display as a method for obtaining specific targeted peptide agents and offers example

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Nagarajan, Niranjana A., Federico Gonzalez, and Nilabh Shastri. "The absence of ER trimming alters peptides presented by non-classical MHC class I molecules (78.8)." Journal of Immunology 182, no. 1_Supplement (2009): 78.8. http://dx.doi.org/10.4049/jimmunol.182.supp.78.8.

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Abstract The nature, function and pathways used to produce peptides for presentation by non-classical MHC class I molecules is poorly understood. Here we show that cells from mice lacking the ER aminopeptidase associated with antigen processing (ERAAP) present an immunologically distinct peptide-MHC class I repertoire. Wild-type mice immunized with ERAAP-deficient cells mount robust CD8 T cell responses specific for peptides presented by classical as well as non-classical MHC I molecules. These CD8 T cells produce pro-inflammatory cytokines and effectively kill ERAAP-deficient target cells in

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Emtestam, L., and O. Olerup. "On T-cell recognition of nickel as a hapten." Acta Dermato-Venereologica 76, no. 5 (1996): 344–47. http://dx.doi.org/10.2340/0001555576344347.

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T-cells recognize antigens as peptides associated with self-molecules encoded by genes of the HLA region. In patients with contact allergy to nickel, T-cells that are specific for non-peptide haptens have been described. Previously, we have isolated HLA class II-restricted nickel-specific T-cell clones from patients with nickel sensitivity. In this paper, data on the fine specificity of a nickel-specific HLA-DR4-restricted clone have been reevaluated. Genomic tissue typing employing polymerase chain reaction and sequence-specific primers were used. Nickel was presented to the T-cell clone by a

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Flower, Cameron T., Lihe Chen, Hyun Jun Jung, Viswanathan Raghuram, Mark A. Knepper, and Chin-Rang Yang. "An integrative proteogenomics approach reveals peptides encoded by annotated lincRNA in the mouse kidney inner medulla." Physiological Genomics 52, no. 10 (2020): 485–91. http://dx.doi.org/10.1152/physiolgenomics.00048.2020.

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Long noncoding RNAs (lncRNAs) are intracellular transcripts longer than 200 nucleotides and lack protein-coding information. A subclass of lncRNA known as long intergenic noncoding RNAs (lincRNAs) are transcribed from genomic regions that share no overlap with annotated protein-coding genes. Increasing evidence has shown that some annotated lincRNA transcripts do in fact contain open reading frames (ORFs) encoding functional short peptides in the cell. Few robust methods for lincRNA-encoded peptide identification have been reported, and the tissue-specific expression of these peptides has been

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Buonocore, Michela, Manuela Grimaldi, Angelo Santoro, et al. "Exploiting the Features of Short Peptides to Recognize Specific Cell Surface Markers." International Journal of Molecular Sciences 24, no. 21 (2023): 15610. http://dx.doi.org/10.3390/ijms242115610.

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Antibodies are the macromolecules of choice to ensure specific recognition of biomarkers in biological assays. However, they present a range of shortfalls including a relatively high production cost and limited tissue penetration. Peptides are relatively small molecules able to reproduce sequences of highly specific paratopes and, although they have less biospecificity than antibodies, they offer advantages like ease of synthesis, modifications of their amino acid sequences and tagging with fluorophores and other molecules required for detection. This work presents a strategy to design peptide

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Pandey, Shashank, Gaurav Malviya, and Magdalena Chottova Dvorakova. "Role of Peptides in Diagnostics." International Journal of Molecular Sciences 22, no. 16 (2021): 8828. http://dx.doi.org/10.3390/ijms22168828.

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The specificity of a diagnostic assay depends upon the purity of the biomolecules used as a probe. To get specific and accurate information of a disease, the use of synthetic peptides in diagnostics have increased in the last few decades, because of their high purity profile and ability to get modified chemically. The discovered peptide probes are used either in imaging diagnostics or in non-imaging diagnostics. In non-imaging diagnostics, techniques such as Enzyme-Linked Immunosorbent Assay (ELISA), lateral flow devices (i.e., point-of-care testing), or microarray or LC-MS/MS are used for dir

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Saipriya, S. *1, and Kumar Chava 2. Vijay. "HOST PROTEASE INHIBITION BY SPECIFIC PATHOGENS IN PERIODONTAL DISEASE." International Journal of Research - Granthaalayah 6, no. 4 (2018): 131–37. https://doi.org/10.5281/zenodo.1242613.

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Proteolytic tissue degradation is a typical phenomenon in chronic inflammatory periodontal disease with the uncontrolled release of host and bacterial derived proteases causing self-digestion and tissue destruction. Antimicrobial proteins and peptides constitute a diverse class of host defense molecules that act early to combat invasion and infection with bacteria and other microorganisms and protease inhibitors forms one of the functional classes of antimicrobial peptides. Plasma protease inhibitors present in gingival crevicular fluid as well as tissues may play a critical role in the protec

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Xu, Xiao-Chun, Todd Howard, and T. Mohanakumar. "TISSUE-SPECIFIC PEPTIDES INFLUENCE HUMAN T CELL REPERTOIRE TO PORCINE XENOANTIGENS1." Transplantation 72, no. 7 (2001): 1205–12. http://dx.doi.org/10.1097/00007890-200110150-00004.

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Ryu, Ji-Hwan, Ki-Bum Nam, Chun-Taek Oh, et al. "The Homeobox Gene Caudal Regulates Constitutive Local Expression of Antimicrobial Peptide Genes in Drosophila Epithelia." Molecular and Cellular Biology 24, no. 1 (2004): 172–85. http://dx.doi.org/10.1128/mcb.24.1.172-185.2004.

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ABSTRACT In Drosophila melanogaster, although the NF-κB transcription factors play a pivotal role in the inducible expression of innate immune genes, such as antimicrobial peptide genes, the exact regulatory mechanism of the tissue-specific constitutive expression of these genes in barrier epithelia is largely unknown. Here, we show that the Drosophila homeobox gene product Caudal functions as the innate immune transcription modulator that is responsible for the constitutive local expression of antimicrobial peptides cecropin and drosomycin in a tissue-specific manner. These results suggest th

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Visseren, M. J., A. van Elsas, E. I. van der Voort, et al. "CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells." Journal of Immunology 154, no. 8 (1995): 3991–98. http://dx.doi.org/10.4049/jimmunol.154.8.3991.

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Abstract CTL that lyse melanoma cells were previously isolated from several melanoma patients. Such CTL recognize autologous proteins, indicating the occurrence of autoreactive T cells in melanoma patients. We have now raised CTL, using responding T lymphocytes from healthy donor blood, that lysed not only cells incubated with an HLA-A*0201-binding tyrosinase peptide but also melanoma cells endogenously processing and presenting the epitope. Our results suggest that autoreactive CTL precursors are present in healthy donor blood and can be activated in vitro with synthetic peptides presented on

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Kuhn-Nentwig, Lucia, Nicolas Langenegger, Manfred Heller, Dominique Koua, and Wolfgang Nentwig. "The Dual Prey-Inactivation Strategy of Spiders—In-Depth Venomic Analysis of Cupiennius salei." Toxins 11, no. 3 (2019): 167. http://dx.doi.org/10.3390/toxins11030167.

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Most knowledge of spider venom concerns neurotoxins acting on ion channels, whereas proteins and their significance for the envenomation process are neglected. The here presented comprehensive analysis of the venom gland transcriptome and proteome of Cupiennius salei focusses on proteins and cysteine-containing peptides and offers new insight into the structure and function of spider venom, here described as the dual prey-inactivation strategy. After venom injection, many enzymes and proteins, dominated by α-amylase, angiotensin-converting enzyme, and cysteine-rich secretory proteins, interact

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Hastwell, April H., Peter M. Gresshoff, and Brett J. Ferguson. "The structure and activity of nodulation-suppressing CLE peptide hormones of legumes." Functional Plant Biology 42, no. 3 (2015): 229. http://dx.doi.org/10.1071/fp14222.

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Legumes form a highly-regulated symbiotic relationship with specific soil bacteria known as rhizobia. This interaction results in the de novo formation of root organs called nodules, in which the rhizobia fix atmospheric di-nitrogen (N2) for the plant. Molecular mechanisms that regulate the nodulation process include the systemic ‘autoregulation of nodulation’ and the local nitrogen-regulation of nodulation pathways. Both pathways are mediated by novel peptide hormones called CLAVATA/ESR-related (CLE) peptides that act to suppress nodulation via negative feedback loops. The mature peptides are

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Lord, A. P. D., A. A. Martin, F. J. Ballard, and L. C. Read. "Transfer of insulin-like growth factor (IGF)-I from blood to intestine: comparison with IGFs that bind poorly to IGF-binding proteins." Journal of Endocrinology 141, no. 3 (1994): 505–15. http://dx.doi.org/10.1677/joe.0.1410505.

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Abstract The net transfer of 125I-labelled insulin-like growth factor (IGF)-I from the blood to the distal small intestine was measured in anaesthetized lambs using a non-recirculating vascular-perfused intestine. To determine whether IGF-binding proteins (IGFBPs) reduce net IGF transfer, radio-labelled IGF-I was compared with two analogues, des(1–3)IGF-I and LR3IGF-I, which show reduced affinity for IGFBPs. Radiolabelled IGF-I, des(1–3)IGF-I or LR3IGF-I (1 ng/ml plasma) was infused for 45 min into the arterial supply of a 10 cm intestinal segment, either in the absence of added unlabelled pep

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Orlandin, Andrea, Paolo Dolcet, Barbara Biondi, et al. "Covalent Graft of Lipopeptides and Peptide Dendrimers to Cellulose Fibers." Coatings 9, no. 10 (2019): 606. http://dx.doi.org/10.3390/coatings9100606.

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Introduction: Bacterial proliferation in health environments may lead to the development of specific pathologies, but can be highly dangerous under particular conditions, such as during chemotherapy. To limit the spread of infections, it is helpful to use gauzes and clothing containing antibacterial agents. As cotton tissues are widespread in health care environments, in this contribution we report the preparation of cellulose fibers characterized by the covalent attachment of lipopeptides as possible antimicrobial agents. Aim: To covalently link peptides to cotton samples and characterize the

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Olivares-Navarrete, Rene, Sharon L. Hyzy, Argelia Almaguer-Flores, et al. "Amelogenin Peptide Extract Increases Differentiation and Angiogenic and Local Factor Production and Inhibits Apoptosis in Human Osteoblasts." ISRN Biomaterials 2013 (August 1, 2013): 1–11. http://dx.doi.org/10.5402/2013/347318.

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Enamel matrix derivative (EMD), a decellularized porcine extracellular matrix (ECM), is used clinically in periodontal tissue regeneration. Amelogenin, EMD’s principal component, spontaneously assembles into nanospheres in vivo, forming an ECM complex that releases proteolytically cleaved peptides. However, the role of amelogenin or amelogenin peptides in mediating osteoblast response to EMD is not clear. Human MG63 osteoblast-like cells or normal human osteoblasts were treated with recombinant human amelogenin or a 5 kDa tyrosine-rich amelogenin peptide (TRAP) isolated from EMD and the effect

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Liu, Edwin, Kristen McDaniel, Stephanie Case, et al. "Exploring T Cell Reactivity to Gliadin in Young Children with Newly Diagnosed Celiac Disease." Autoimmune Diseases 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/927190.

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Class II major histocompatibility molecules confer disease risk in Celiac disease (CD) by presenting gliadin peptides to CD4 T cells in the small intestine. Deamidation of gliadin peptides by tissue transglutaminase creates immunogenic peptides presented by HLA-DQ2 and DQ8 molecules to activate proinflammatory CD4 T cells. Detecting gliadin specific T cell responses from the peripheral blood has been challenging due to low circulating frequencies and heterogeneity in response to gliadin epitopes. We investigated the peripheral T cell responses to alpha and gamma gliadin epitopes in young child

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